FBXO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.66505190
2mitotic metaphase plate congression (GO:0007080)5.37625237
3DNA strand elongation involved in DNA replication (GO:0006271)5.22493356
4DNA replication initiation (GO:0006270)5.06478334
5DNA strand elongation (GO:0022616)4.97363653
6DNA unwinding involved in DNA replication (GO:0006268)4.95383610
7DNA replication checkpoint (GO:0000076)4.94970671
8telomere maintenance via semi-conservative replication (GO:0032201)4.94543559
9protein localization to chromosome, centromeric region (GO:0071459)4.91714794
10CENP-A containing nucleosome assembly (GO:0034080)4.90960058
11kinetochore organization (GO:0051383)4.82109605
12chromatin remodeling at centromere (GO:0031055)4.80406239
13mitotic chromosome condensation (GO:0007076)4.76230102
14metaphase plate congression (GO:0051310)4.75039698
15attachment of spindle microtubules to kinetochore (GO:0008608)4.65533619
16mitotic sister chromatid segregation (GO:0000070)4.57036821
17telomere maintenance via recombination (GO:0000722)4.52364568
18mitotic recombination (GO:0006312)4.48687375
19DNA replication-independent nucleosome organization (GO:0034724)4.41039002
20DNA replication-independent nucleosome assembly (GO:0006336)4.41039002
21establishment of chromosome localization (GO:0051303)4.29918808
22kinetochore assembly (GO:0051382)4.29138624
23sister chromatid segregation (GO:0000819)4.25253811
24regulation of spindle organization (GO:0090224)4.24003857
25DNA replication-dependent nucleosome assembly (GO:0006335)4.23272635
26DNA replication-dependent nucleosome organization (GO:0034723)4.23272635
27mitotic nuclear envelope disassembly (GO:0007077)4.13096112
28histone exchange (GO:0043486)4.11067591
29DNA ligation (GO:0006266)4.06708214
30telomere maintenance via telomere lengthening (GO:0010833)4.04813460
31* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01658184
32nucleobase biosynthetic process (GO:0046112)3.92952750
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.87330555
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87227878
35meiotic chromosome segregation (GO:0045132)3.82405553
36membrane disassembly (GO:0030397)3.81769194
37nuclear envelope disassembly (GO:0051081)3.81769194
38nuclear pore organization (GO:0006999)3.79588164
39purine nucleobase biosynthetic process (GO:0009113)3.77946040
40spindle checkpoint (GO:0031577)3.77505968
41positive regulation of chromosome segregation (GO:0051984)3.71615808
42establishment of integrated proviral latency (GO:0075713)3.70799048
43protein localization to chromosome (GO:0034502)3.67293349
44regulation of DNA endoreduplication (GO:0032875)3.66644875
45protein K6-linked ubiquitination (GO:0085020)3.61984509
46pore complex assembly (GO:0046931)3.57246587
47formation of translation preinitiation complex (GO:0001731)3.56306132
48mitotic G2/M transition checkpoint (GO:0044818)3.56159051
49chromosome segregation (GO:0007059)3.55766451
50regulation of mitotic spindle organization (GO:0060236)3.55074555
51spindle assembly checkpoint (GO:0071173)3.54420827
52* regulation of chromosome segregation (GO:0051983)3.52209102
53nuclear pore complex assembly (GO:0051292)3.52059398
54ribosomal small subunit assembly (GO:0000028)3.51545854
55chromatin assembly or disassembly (GO:0006333)3.48311725
56folic acid-containing compound biosynthetic process (GO:0009396)3.47957624
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.47919845
58maturation of SSU-rRNA (GO:0030490)3.47745615
59IMP biosynthetic process (GO:0006188)3.45460020
60mitotic spindle assembly checkpoint (GO:0007094)3.44539206
61mitotic spindle checkpoint (GO:0071174)3.42114474
62* negative regulation of chromosome segregation (GO:0051985)3.40109019
63DNA double-strand break processing (GO:0000729)3.38249637
64regulation of sister chromatid cohesion (GO:0007063)3.37667495
65regulation of centrosome cycle (GO:0046605)3.36877975
66* negative regulation of mitotic sister chromatid separation (GO:2000816)3.36737790
67* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36737790
68* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36737790
69* negative regulation of sister chromatid segregation (GO:0033046)3.36737790
70* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35533669
71replication fork processing (GO:0031297)3.35495009
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35019332
73DNA packaging (GO:0006323)3.32659786
74* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32240556
75* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32110306
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.30335973
77DNA duplex unwinding (GO:0032508)3.28835917
78DNA geometric change (GO:0032392)3.28348959
79ribosome assembly (GO:0042255)3.28256835
80ATP-dependent chromatin remodeling (GO:0043044)3.26244015
81microtubule depolymerization (GO:0007019)3.23752541
82telomere maintenance (GO:0000723)3.22663242
83double-strand break repair via nonhomologous end joining (GO:0006303)3.22002938
84non-recombinational repair (GO:0000726)3.22002938
85telomere organization (GO:0032200)3.21984667
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20309666
87chromosome condensation (GO:0030261)3.18937943
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.16093565
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16093565
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15829445
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15829445
92positive regulation of mitotic sister chromatid separation (GO:1901970)3.15829445
93regulation of mitotic spindle checkpoint (GO:1903504)3.15464618
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15464618
95* regulation of sister chromatid segregation (GO:0033045)3.15420903
96* regulation of mitotic sister chromatid separation (GO:0010965)3.15420903
97* regulation of mitotic sister chromatid segregation (GO:0033047)3.15420903
98ribosome biogenesis (GO:0042254)3.15372698
99DNA deamination (GO:0045006)3.13887384
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.13384431
101DNA topological change (GO:0006265)3.13373125
102* mitotic cell cycle (GO:0000278)3.13116090
103mismatch repair (GO:0006298)3.13104526
104mitotic sister chromatid cohesion (GO:0007064)3.11766785
105translesion synthesis (GO:0019985)3.10144360
106DNA strand renaturation (GO:0000733)3.08657831
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07915941
108IMP metabolic process (GO:0046040)3.07693972
109DNA conformation change (GO:0071103)3.05916737
110transcription-coupled nucleotide-excision repair (GO:0006283)3.05886208
111spliceosomal snRNP assembly (GO:0000387)3.05306261
112DNA catabolic process, exonucleolytic (GO:0000738)3.05149281
113postreplication repair (GO:0006301)3.03609781
114ribonucleoprotein complex biogenesis (GO:0022613)3.02505418
115histone-serine phosphorylation (GO:0035404)3.01555475
116regulation of centriole replication (GO:0046599)3.00892739
117* cell cycle G1/S phase transition (GO:0044843)2.99982092
118* G1/S transition of mitotic cell cycle (GO:0000082)2.99982092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.59030110
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40402503
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.00861209
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.85960125
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33038896
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10535648
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86472743
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.74808869
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72442240
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61582162
11AR_21909140_ChIP-Seq_LNCAP_Human2.60847061
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49365897
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.46913935
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.44930907
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40406839
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33757849
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31544710
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27269639
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.24792213
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24171986
21* XRN2_22483619_ChIP-Seq_HELA_Human2.17807815
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15745957
23VDR_23849224_ChIP-Seq_CD4+_Human2.02936862
24E2F7_22180533_ChIP-Seq_HELA_Human10.1657522
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.91568813
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91492411
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90113286
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88928923
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86419082
30FOXP3_21729870_ChIP-Seq_TREG_Human1.83320330
31DCP1A_22483619_ChIP-Seq_HELA_Human1.81250381
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80612773
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73798817
34TTF2_22483619_ChIP-Seq_HELA_Human1.73777654
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70539725
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69367688
37* GABP_19822575_ChIP-Seq_HepG2_Human1.64920519
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63791268
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63736326
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62709791
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62520851
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59544030
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55526059
44CIITA_25753668_ChIP-Seq_RAJI_Human1.52825706
45ELK1_19687146_ChIP-ChIP_HELA_Human1.52562470
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51174269
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42548814
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40329007
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39664434
50MYC_22102868_ChIP-Seq_BL_Human1.39048169
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38915257
52KDM5A_27292631_Chip-Seq_BREAST_Human1.36721466
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34750792
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.34192094
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34067389
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32975754
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31314789
58* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31126187
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.29306509
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26260983
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24435200
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21903095
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18552760
64EWS_26573619_Chip-Seq_HEK293_Human1.17711515
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17262378
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16368021
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15371252
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.15091038
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12671999
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11910539
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11308994
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10884507
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.09022676
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.08185400
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05679379
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.01185545
77IRF1_19129219_ChIP-ChIP_H3396_Human1.00213493
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98845996
79TFEB_21752829_ChIP-Seq_HELA_Human0.98517192
80* MYC_18940864_ChIP-ChIP_HL60_Human0.98335969
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97482313
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96007715
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95621355
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95615732
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94686094
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94119003
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.93429362
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93067300
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90076762
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90069121
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88634793
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87715190
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85050296
94VDR_21846776_ChIP-Seq_THP-1_Human0.83785775
95FUS_26573619_Chip-Seq_HEK293_Human0.83006842
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.82743799
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82517400
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81371760
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80589578
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79782550
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78591511
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78334513
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78248069
104* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77579826
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76800121
106SPI1_23547873_ChIP-Seq_NB4_Human0.75040500
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74817232
108* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73588638
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.73244585
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73097602
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73085614
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73085614
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69046941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.95100086
2MP0010094_abnormal_chromosome_stability5.40221757
3MP0003111_abnormal_nucleus_morphology5.07958037
4* MP0004957_abnormal_blastocyst_morpholog4.58872272
5* MP0003077_abnormal_cell_cycle4.40870619
6MP0008057_abnormal_DNA_replication4.34985343
7MP0008058_abnormal_DNA_repair3.47557261
8MP0008007_abnormal_cellular_replicative3.00791620
9MP0008932_abnormal_embryonic_tissue2.85876441
10MP0003123_paternal_imprinting2.54342364
11MP0001730_embryonic_growth_arrest2.46754213
12MP0000350_abnormal_cell_proliferation2.38046586
13MP0008877_abnormal_DNA_methylation2.29772123
14MP0009697_abnormal_copulation2.29134087
15MP0002396_abnormal_hematopoietic_system2.18045594
16MP0003718_maternal_effect2.04679487
17MP0010307_abnormal_tumor_latency2.00705373
18MP0010352_gastrointestinal_tract_polyps1.87297167
19MP0001697_abnormal_embryo_size1.84937425
20MP0003786_premature_aging1.82661588
21* MP0001672_abnormal_embryogenesis/_devel1.80982579
22* MP0005380_embryogenesis_phenotype1.80982579
23MP0000490_abnormal_crypts_of1.73896523
24* MP0002085_abnormal_embryonic_tissue1.61698229
25* MP0002080_prenatal_lethality1.61668190
26MP0003984_embryonic_growth_retardation1.58640190
27MP0002088_abnormal_embryonic_growth/wei1.55051273
28MP0000313_abnormal_cell_death1.50175001
29MP0002019_abnormal_tumor_incidence1.50012271
30MP0003121_genomic_imprinting1.47944068
31MP0002084_abnormal_developmental_patter1.45512884
32* MP0002086_abnormal_extraembryonic_tissu1.40444802
33MP0006292_abnormal_olfactory_placode1.36891175
34MP0004808_abnormal_hematopoietic_stem1.34912742
35MP0010030_abnormal_orbit_morphology1.33679585
36MP0008789_abnormal_olfactory_epithelium1.33448241
37MP0003567_abnormal_fetal_cardiomyocyte1.32047667
38MP0003890_abnormal_embryonic-extraembry1.32034001
39MP0004197_abnormal_fetal_growth/weight/1.30657120
40MP0002210_abnormal_sex_determination1.30136220
41MP0001346_abnormal_lacrimal_gland1.29595201
42MP0003315_abnormal_perineum_morphology1.29128740
43MP0006054_spinal_hemorrhage1.25648297
44MP0002009_preneoplasia1.22147215
45MP0002938_white_spotting1.14493762
46MP0002697_abnormal_eye_size1.14176982
47MP0001145_abnormal_male_reproductive1.14047568
48MP0003136_yellow_coat_color1.12149599
49MP0005076_abnormal_cell_differentiation1.11672020
50MP0003806_abnormal_nucleotide_metabolis1.09988897
51MP0002233_abnormal_nose_morphology1.09333218
52MP0001293_anophthalmia1.08426866
53MP0000703_abnormal_thymus_morphology1.07866859
54MP0001929_abnormal_gametogenesis1.06425516
55MP0009333_abnormal_splenocyte_physiolog1.06040032
56MP0005499_abnormal_olfactory_system1.05036935
57MP0005394_taste/olfaction_phenotype1.05036935
58MP0000653_abnormal_sex_gland1.03936947
59MP0001545_abnormal_hematopoietic_system1.03447530
60MP0005397_hematopoietic_system_phenotyp1.03447530
61MP0001119_abnormal_female_reproductive1.02117800
62MP0002234_abnormal_pharynx_morphology1.01896692
63MP0003763_abnormal_thymus_physiology1.00387030
64MP0006035_abnormal_mitochondrial_morpho0.96781889
65MP0002398_abnormal_bone_marrow0.96639296
66MP0002722_abnormal_immune_system0.94234594
67MP0003941_abnormal_skin_development0.92688546
68MP0002160_abnormal_reproductive_system0.91080211
69MP0003119_abnormal_digestive_system0.90715801
70MP0000049_abnormal_middle_ear0.90345127
71MP0000689_abnormal_spleen_morphology0.89949888
72MP0003937_abnormal_limbs/digits/tail_de0.89601732
73MP0009672_abnormal_birth_weight0.89382442
74MP0001529_abnormal_vocalization0.87056559
75MP0002111_abnormal_tail_morphology0.85413249
76MP0005389_reproductive_system_phenotype0.84632324
77MP0004133_heterotaxia0.83073016
78MP0003861_abnormal_nervous_system0.83042976
79MP0008995_early_reproductive_senescence0.81299136
80MP0005384_cellular_phenotype0.78716953
81MP0003755_abnormal_palate_morphology0.78227427
82MP0006072_abnormal_retinal_apoptosis0.77977207
83MP0009053_abnormal_anal_canal0.77756775
84MP0002653_abnormal_ependyma_morphology0.75964771
85MP0000358_abnormal_cell_content/0.75101380
86MP0005621_abnormal_cell_physiology0.74982696
87MP0003186_abnormal_redox_activity0.73761737
88MP0003698_abnormal_male_reproductive0.73630193
89MP0001915_intracranial_hemorrhage0.73528147
90MP0002102_abnormal_ear_morphology0.73475461
91MP0000537_abnormal_urethra_morphology0.73388193
92MP0002429_abnormal_blood_cell0.72858514
93MP0002163_abnormal_gland_morphology0.72619567
94MP0005187_abnormal_penis_morphology0.69782596
95MP0009703_decreased_birth_body0.68378609
96MP0000858_altered_metastatic_potential0.68165524
97MP0003385_abnormal_body_wall0.67536446
98MP0003935_abnormal_craniofacial_develop0.67459836
99MP0000372_irregular_coat_pigmentation0.66251624
100MP0000631_abnormal_neuroendocrine_gland0.66177551
101MP0001286_abnormal_eye_development0.66083518
102MP0003699_abnormal_female_reproductive0.65358738
103MP0005023_abnormal_wound_healing0.64408095
104MP0001727_abnormal_embryo_implantation0.64119246
105MP0002132_abnormal_respiratory_system0.63844484
106MP0006036_abnormal_mitochondrial_physio0.63672246
107MP0005391_vision/eye_phenotype0.63402802
108MP0003943_abnormal_hepatobiliary_system0.63398619
109MP0000647_abnormal_sebaceous_gland0.63318684
110MP0001919_abnormal_reproductive_system0.63255086
111MP0000477_abnormal_intestine_morphology0.61494584
112MP0003705_abnormal_hypodermis_morpholog0.61186451
113MP0002092_abnormal_eye_morphology0.59783466
114MP0001849_ear_inflammation0.58757708
115MP0002177_abnormal_outer_ear0.57917423
116MP0003942_abnormal_urinary_system0.57405463
117MP0009278_abnormal_bone_marrow0.57012044
118MP0009250_abnormal_appendicular_skeleto0.56651508
119MP0000428_abnormal_craniofacial_morphol0.56421580
120MP0004147_increased_porphyrin_level0.55689986
121MP0003656_abnormal_erythrocyte_physiolo0.55463929
122MP0000716_abnormal_immune_system0.55205785
123MP0003221_abnormal_cardiomyocyte_apopto0.55106608
124MP0005395_other_phenotype0.53771333
125MP0002095_abnormal_skin_pigmentation0.53632291
126MP0000566_synostosis0.51410485
127MP0002161_abnormal_fertility/fecundity0.50805397
128MP0000432_abnormal_head_morphology0.50326004
129MP0005266_abnormal_metabolism0.49926302
130MP0000465_gastrointestinal_hemorrhage0.47517535
131MP0003938_abnormal_ear_development0.46467096
132MP0002932_abnormal_joint_morphology0.45740611
133MP0003115_abnormal_respiratory_system0.45274893

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.91204025
2Chromsome breakage (HP:0040012)4.58218681
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43480479
4Breast hypoplasia (HP:0003187)4.36734971
5Reticulocytopenia (HP:0001896)4.03627358
6Patellar aplasia (HP:0006443)3.95884465
7Abnormality of chromosome stability (HP:0003220)3.79625700
8Meckel diverticulum (HP:0002245)3.75835689
9Aplasia/Hypoplasia of the patella (HP:0006498)3.71022035
10Oral leukoplakia (HP:0002745)3.64133041
11Abnormality of the preputium (HP:0100587)3.64076478
12Abnormality of the ileum (HP:0001549)3.56283093
13Colon cancer (HP:0003003)3.43640095
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.41760794
15Carpal bone hypoplasia (HP:0001498)3.41184275
16Abnormality of cells of the erythroid lineage (HP:0012130)3.36232994
17Impulsivity (HP:0100710)3.33478497
18Absent radius (HP:0003974)3.27853576
19Selective tooth agenesis (HP:0001592)3.26732706
20Small intestinal stenosis (HP:0012848)3.22697685
21Duodenal stenosis (HP:0100867)3.22697685
22Abnormal number of erythroid precursors (HP:0012131)3.21777315
23Medulloblastoma (HP:0002885)3.12994335
24Absent forearm bone (HP:0003953)3.05132932
25Aplasia involving forearm bones (HP:0009822)3.05132932
26Absent thumb (HP:0009777)3.00599703
27Abnormality of the labia minora (HP:0012880)3.00356853
28Abnormal lung lobation (HP:0002101)2.98158910
29Myelodysplasia (HP:0002863)2.96254319
30Supernumerary spleens (HP:0009799)2.92332379
31Ependymoma (HP:0002888)2.87058295
32Degeneration of anterior horn cells (HP:0002398)2.75180321
33Abnormality of the anterior horn cell (HP:0006802)2.75180321
34Rough bone trabeculation (HP:0100670)2.74515598
35Bone marrow hypocellularity (HP:0005528)2.69502136
36Abnormality of the duodenum (HP:0002246)2.67877853
37Cortical dysplasia (HP:0002539)2.67456651
38Aplastic anemia (HP:0001915)2.66331953
39Ectopic kidney (HP:0000086)2.64253155
40Sloping forehead (HP:0000340)2.63222419
41Agnosia (HP:0010524)2.62544220
42Rhabdomyosarcoma (HP:0002859)2.60076390
43Increased nuchal translucency (HP:0010880)2.51391030
44Horseshoe kidney (HP:0000085)2.47296811
45Abnormal number of incisors (HP:0011064)2.46379547
46Macrocytic anemia (HP:0001972)2.44486994
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43177983
48Nephroblastoma (Wilms tumor) (HP:0002667)2.42819756
49Neoplasm of the pancreas (HP:0002894)2.42692281
5011 pairs of ribs (HP:0000878)2.41323674
51Premature graying of hair (HP:0002216)2.39541513
52Triphalangeal thumb (HP:0001199)2.37955475
53Facial hemangioma (HP:0000329)2.37010882
54Duplicated collecting system (HP:0000081)2.35733555
55Tracheoesophageal fistula (HP:0002575)2.35394952
56Atresia of the external auditory canal (HP:0000413)2.34321021
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.32865610
58Abnormality of the carotid arteries (HP:0005344)2.32401589
59Cafe-au-lait spot (HP:0000957)2.26500692
60Cerebral hypomyelination (HP:0006808)2.25987230
61Embryonal renal neoplasm (HP:0011794)2.25428740
62Microretrognathia (HP:0000308)2.25263324
63Proximal placement of thumb (HP:0009623)2.25074320
64Pallor (HP:0000980)2.24239352
65Cellular immunodeficiency (HP:0005374)2.23052060
66Short thumb (HP:0009778)2.22473993
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22387194
68Clubbing of toes (HP:0100760)2.18863237
69Basal cell carcinoma (HP:0002671)2.16908234
70Squamous cell carcinoma (HP:0002860)2.16698546
71Arteriovenous malformation (HP:0100026)2.15641392
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15545617
73Volvulus (HP:0002580)2.15408130
74Deviation of the thumb (HP:0009603)2.14510145
75Premature ovarian failure (HP:0008209)2.13184645
76Microvesicular hepatic steatosis (HP:0001414)2.09662089
77Choanal atresia (HP:0000453)2.07372424
78Abnormality of the renal collecting system (HP:0004742)2.05658566
79Embryonal neoplasm (HP:0002898)2.03059601
80Hypoplastic pelvis (HP:0008839)2.01014522
81Neoplasm of the colon (HP:0100273)2.00892255
82Slender long bone (HP:0003100)1.99134683
83Abnormality of cochlea (HP:0000375)1.98726048
84Short middle phalanx of the 5th finger (HP:0004220)1.98580963
85Duplication of thumb phalanx (HP:0009942)1.97093472
86Cleft eyelid (HP:0000625)1.96731250
87Abnormal trabecular bone morphology (HP:0100671)1.96205235
88Abnormal umbilical cord blood vessels (HP:0011403)1.96099901
89Single umbilical artery (HP:0001195)1.96099901
90Abnormality of the fetal cardiovascular system (HP:0010948)1.96099901
91High pitched voice (HP:0001620)1.93261330
92Abnormality of abdominal situs (HP:0011620)1.91134016
93Abdominal situs inversus (HP:0003363)1.91134016
94Prominent nose (HP:0000448)1.90871879
95Secondary amenorrhea (HP:0000869)1.90295182
96Abnormality of pyrimidine metabolism (HP:0004353)1.88828807
97Short 4th metacarpal (HP:0010044)1.87876053
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87876053
99Missing ribs (HP:0000921)1.86308384
100Abnormality of DNA repair (HP:0003254)1.85769631
101Neoplasm of striated muscle (HP:0009728)1.84799194
102Trismus (HP:0000211)1.84601892
103Lymphoma (HP:0002665)1.84160585
104Oligodactyly (hands) (HP:0001180)1.81019564
105Facial cleft (HP:0002006)1.80875720
106Multiple enchondromatosis (HP:0005701)1.79148938
107Abnormality of glycolysis (HP:0004366)1.78529719
108Breast aplasia (HP:0100783)1.77580190
109Abnormality of the septum pellucidum (HP:0007375)1.77160170
110Increased serum pyruvate (HP:0003542)1.76324915
111Overlapping toe (HP:0001845)1.76106720
112Abnormality of the heme biosynthetic pathway (HP:0010472)1.75635070
113Abnormality of reticulocytes (HP:0004312)1.74684528
114Abnormality of chromosome segregation (HP:0002916)1.72249645
115Glioma (HP:0009733)1.72023153
116Aplasia/Hypoplasia of the breasts (HP:0010311)1.71463081
117Pancytopenia (HP:0001876)1.71292270
118Irregular epiphyses (HP:0010582)1.71115816
119Preaxial hand polydactyly (HP:0001177)1.70755871
120Hypoplasia of the pons (HP:0012110)1.70223615
121Abnormality of the pons (HP:0007361)1.69346558
122High anterior hairline (HP:0009890)1.68148528
123Oligodactyly (HP:0012165)1.66068983
124Esophageal atresia (HP:0002032)1.64932674
125Absent septum pellucidum (HP:0001331)1.63692419
126Deep philtrum (HP:0002002)1.61189216
127Progressive muscle weakness (HP:0003323)1.60305817
128Septo-optic dysplasia (HP:0100842)1.59115221
129Progressive external ophthalmoplegia (HP:0000590)1.57838197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11371531
2WEE14.77969298
3CDC74.75254011
4NEK23.31106383
5TTK3.04531654
6EIF2AK12.94780822
7NEK12.80908449
8SRPK12.68306627
9BRSK22.57267971
10PLK42.55171798
11* PLK12.30374836
12ACVR1B2.09911589
13VRK11.98470838
14AURKB1.98120893
15BRSK11.83153435
16PLK31.81928866
17CCNB11.79972466
18VRK21.78442795
19CHEK21.72387233
20ATR1.71996248
21CDK71.68371535
22MKNK11.67135734
23TSSK61.66324041
24TESK21.61953058
25TLK11.61029649
26STK161.56729148
27EIF2AK31.55656057
28STK101.55629578
29NME21.52929817
30NUAK11.51950103
31MAP3K81.51049007
32DYRK31.47734837
33CDK41.44461306
34STK41.43865436
35AURKA1.42500065
36PASK1.42192870
37TAF11.41882786
38RPS6KB21.41825488
39RPS6KA41.33155368
40CDK121.30040887
41CHEK11.26559689
42MST41.21678592
43MKNK21.20474472
44TRIM281.11963457
45MELK1.08074911
46EEF2K1.01492248
47ZAK0.99210815
48PAK40.99072239
49BMPR1B0.95298199
50ATM0.94898675
51BRAF0.91545850
52CDK20.88760695
53EPHA20.88608413
54PIM10.87467211
55EIF2AK20.84538186
56CDK60.83679625
57CDK80.81093308
58MAP3K100.79279292
59TGFBR10.77922093
60SCYL20.77293428
61CLK10.76013816
62STK38L0.75275623
63TNIK0.74661233
64CDK10.73070839
65PBK0.67665574
66STK30.65973350
67NME10.64366697
68CSNK2A10.61757705
69PAK10.58568970
70CSNK2A20.57734843
71ERBB40.57145703
72ALK0.56274943
73MAPKAPK30.56060509
74ERBB30.54698206
75RPS6KA50.54302983
76PNCK0.53402494
77BCR0.51471773
78CDK30.51377567
79BRD40.50430277
80LRRK20.48884923
81FLT30.48312038
82SMG10.47617779
83PRKCI0.44913788
84LATS20.43169579
85PLK20.42918150
86MAP4K10.41520517
87CSNK1G10.38458470
88MAP4K20.36004526
89STK240.35146865
90DYRK20.34918125
91CSNK1G30.32437877
92KDR0.31209052
93GRK60.31182550
94PRKDC0.30934366
95WNK30.30887577
96AKT20.30319884
97CDK140.28161425
98CSNK1A1L0.26728793
99MAP2K30.25856296
100PIM20.25148910
101FGFR10.23645974
102MAPKAPK50.22967420
103TESK10.22716876
104LATS10.22492719
105CSNK1E0.22148445
106MAPK140.21811356
107CDK11A0.20576368
108MAP3K40.20361227
109MARK30.18535869
110CSNK1D0.18471857
111CDK150.18470814
112MAP3K110.17804312
113AKT10.17794570
114NEK90.16885183
115CSF1R0.16640258
116MTOR0.16169929
117CDK180.16021083
118PKN20.15998938
119RAF10.15521743
120MAPK110.14759391
121CDK90.14335835
122BTK0.14292554
123YES10.14048577
124BCKDK0.13455738

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.57710935
2Mismatch repair_Homo sapiens_hsa034304.74702471
3Homologous recombination_Homo sapiens_hsa034403.53706342
4Base excision repair_Homo sapiens_hsa034103.46315723
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45342972
6Cell cycle_Homo sapiens_hsa041103.29661919
7Spliceosome_Homo sapiens_hsa030403.24307364
8RNA transport_Homo sapiens_hsa030133.09439458
9Nucleotide excision repair_Homo sapiens_hsa034203.03456522
10RNA polymerase_Homo sapiens_hsa030202.94670698
11Ribosome_Homo sapiens_hsa030102.91272225
12Fanconi anemia pathway_Homo sapiens_hsa034602.75827997
13One carbon pool by folate_Homo sapiens_hsa006702.73030473
14Proteasome_Homo sapiens_hsa030502.70658161
15Pyrimidine metabolism_Homo sapiens_hsa002402.48549807
16Non-homologous end-joining_Homo sapiens_hsa034502.28027516
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14150866
18RNA degradation_Homo sapiens_hsa030182.05065384
19Basal transcription factors_Homo sapiens_hsa030221.91350568
20p53 signaling pathway_Homo sapiens_hsa041151.83699750
21mRNA surveillance pathway_Homo sapiens_hsa030151.75275903
22Systemic lupus erythematosus_Homo sapiens_hsa053221.52770925
23Purine metabolism_Homo sapiens_hsa002301.29170057
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27416847
25* Oocyte meiosis_Homo sapiens_hsa041141.21659027
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17114052
27Epstein-Barr virus infection_Homo sapiens_hsa051691.12503211
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04433292
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03436313
30Viral carcinogenesis_Homo sapiens_hsa052031.00823497
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00808932
32Parkinsons disease_Homo sapiens_hsa050120.99145948
33Pyruvate metabolism_Homo sapiens_hsa006200.96772919
34Steroid biosynthesis_Homo sapiens_hsa001000.95925391
35Vitamin B6 metabolism_Homo sapiens_hsa007500.95409558
36Herpes simplex infection_Homo sapiens_hsa051680.88015969
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84323740
38Oxidative phosphorylation_Homo sapiens_hsa001900.83115998
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82509844
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.80120871
41Folate biosynthesis_Homo sapiens_hsa007900.79048086
42Antigen processing and presentation_Homo sapiens_hsa046120.75451428
43Propanoate metabolism_Homo sapiens_hsa006400.75192774
44HTLV-I infection_Homo sapiens_hsa051660.74719901
45Biosynthesis of amino acids_Homo sapiens_hsa012300.73183331
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.73052681
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.72904562
48MicroRNAs in cancer_Homo sapiens_hsa052060.71269040
49Pentose phosphate pathway_Homo sapiens_hsa000300.69741607
50Selenocompound metabolism_Homo sapiens_hsa004500.69462115
51Small cell lung cancer_Homo sapiens_hsa052220.62306254
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61568957
53Alcoholism_Homo sapiens_hsa050340.57626045
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57518032
55Thyroid cancer_Homo sapiens_hsa052160.55654921
56Fatty acid elongation_Homo sapiens_hsa000620.54024068
57Primary immunodeficiency_Homo sapiens_hsa053400.53408608
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51980904
59Glutathione metabolism_Homo sapiens_hsa004800.50630541
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48918336
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46039526
62TGF-beta signaling pathway_Homo sapiens_hsa043500.46012096
63Colorectal cancer_Homo sapiens_hsa052100.41358602
64Apoptosis_Homo sapiens_hsa042100.39778560
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39590765
66Hippo signaling pathway_Homo sapiens_hsa043900.37613380
67Alzheimers disease_Homo sapiens_hsa050100.36760028
68Wnt signaling pathway_Homo sapiens_hsa043100.36758047
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36261415
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32968055
71Hepatitis B_Homo sapiens_hsa051610.32898156
72Basal cell carcinoma_Homo sapiens_hsa052170.32724878
73Legionellosis_Homo sapiens_hsa051340.31341064
74Protein export_Homo sapiens_hsa030600.30363980
75Huntingtons disease_Homo sapiens_hsa050160.29336141
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29306563
77Carbon metabolism_Homo sapiens_hsa012000.28759894
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28607643
79Bladder cancer_Homo sapiens_hsa052190.25019731
80Shigellosis_Homo sapiens_hsa051310.24844485
81Measles_Homo sapiens_hsa051620.23861615
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23523797
83Notch signaling pathway_Homo sapiens_hsa043300.22388608
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.22240414
85Sulfur relay system_Homo sapiens_hsa041220.21963204
86Pathways in cancer_Homo sapiens_hsa052000.21945123
87Chronic myeloid leukemia_Homo sapiens_hsa052200.21866075
88N-Glycan biosynthesis_Homo sapiens_hsa005100.19783440
89Prostate cancer_Homo sapiens_hsa052150.19703900
90Fructose and mannose metabolism_Homo sapiens_hsa000510.19524899
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18558013
92Butanoate metabolism_Homo sapiens_hsa006500.18491561
93Fatty acid metabolism_Homo sapiens_hsa012120.17528418
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16852176
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16509239
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16142960
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15824716
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15637363
99Arachidonic acid metabolism_Homo sapiens_hsa005900.14991460
100Hematopoietic cell lineage_Homo sapiens_hsa046400.14972736
101Adherens junction_Homo sapiens_hsa045200.14921268
102Hedgehog signaling pathway_Homo sapiens_hsa043400.14857505
103Influenza A_Homo sapiens_hsa051640.14619776
104HIF-1 signaling pathway_Homo sapiens_hsa040660.14439814
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14373831
106mTOR signaling pathway_Homo sapiens_hsa041500.13571863
107Metabolic pathways_Homo sapiens_hsa011000.13054820
108FoxO signaling pathway_Homo sapiens_hsa040680.12714083
109Pancreatic cancer_Homo sapiens_hsa052120.11649431
110Viral myocarditis_Homo sapiens_hsa054160.11144958
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10576148
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10428172
113Lysine degradation_Homo sapiens_hsa003100.10029805
114Arginine and proline metabolism_Homo sapiens_hsa003300.09992816
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.09090626
116Non-small cell lung cancer_Homo sapiens_hsa052230.08073420
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06703738
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.05443572
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05223949
120Renin-angiotensin system_Homo sapiens_hsa046140.05179346
121Galactose metabolism_Homo sapiens_hsa000520.05082694
122Melanoma_Homo sapiens_hsa052180.04864424
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03019433

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »