FBXO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.98709957
2central nervous system myelination (GO:0022010)8.98709957
3positive regulation of gamma-delta T cell activation (GO:0046645)6.42958363
4negative regulation of cell killing (GO:0031342)5.79913309
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.79913309
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65477082
7presynaptic membrane organization (GO:0097090)5.44098379
8regulation of B cell receptor signaling pathway (GO:0050855)5.43047424
9response to methylmercury (GO:0051597)5.29312070
10axon ensheathment (GO:0008366)5.03372455
11ensheathment of neurons (GO:0007272)5.03372455
12positive regulation by symbiont of host defense response (GO:0052509)4.98026815
13modulation by symbiont of host defense response (GO:0052031)4.98026815
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.98026815
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.98026815
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.98026815
17modulation by symbiont of host immune response (GO:0052553)4.98026815
18myelination (GO:0042552)4.97211915
19presynaptic membrane assembly (GO:0097105)4.96590527
20neuron cell-cell adhesion (GO:0007158)4.88087072
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80514190
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68754659
23fatty acid elongation (GO:0030497)4.64787799
24microglial cell activation (GO:0001774)4.55924752
25neutrophil activation involved in immune response (GO:0002283)4.55798759
26long-chain fatty acid biosynthetic process (GO:0042759)4.48771081
27regulation of gamma-delta T cell activation (GO:0046643)4.45875419
28antigen processing and presentation of endogenous antigen (GO:0019883)4.45233800
29positive regulation of granulocyte differentiation (GO:0030854)4.42400842
30regulation of gamma-delta T cell differentiation (GO:0045586)4.41040626
31protoporphyrinogen IX metabolic process (GO:0046501)4.26538990
32oligodendrocyte differentiation (GO:0048709)4.14053874
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12501885
34myelin maintenance (GO:0043217)4.12349368
35response to lead ion (GO:0010288)4.07729806
36detection of other organism (GO:0098543)4.04812862
37macrophage activation involved in immune response (GO:0002281)4.00749583
38hepatocyte apoptotic process (GO:0097284)3.95067042
39detection of molecule of bacterial origin (GO:0032490)3.89920655
40negative thymic T cell selection (GO:0045060)3.89394853
41negative T cell selection (GO:0043383)3.89053212
42protoporphyrinogen IX biosynthetic process (GO:0006782)3.88839145
43peptidyl-tyrosine autophosphorylation (GO:0038083)3.88045929
44negative regulation of neurotransmitter transport (GO:0051589)3.87140293
45establishment of mitochondrion localization (GO:0051654)3.84962182
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.84762491
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.78190957
48detection of bacterium (GO:0016045)3.77665353
49positive regulation of B cell differentiation (GO:0045579)3.77283340
50B cell receptor signaling pathway (GO:0050853)3.75162132
51positive thymic T cell selection (GO:0045059)3.72435699
52detection of external biotic stimulus (GO:0098581)3.69189650
53L-amino acid import (GO:0043092)3.68421905
54negative regulation of erythrocyte differentiation (GO:0045647)3.66507846
55cellular extravasation (GO:0045123)3.65887299
56oxygen transport (GO:0015671)3.65616333
57negative regulation of T cell mediated immunity (GO:0002710)3.62750218
58neutrophil mediated immunity (GO:0002446)3.62541179
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61697501
60negative regulation of interleukin-12 production (GO:0032695)3.61325157
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59757654
62response to host immune response (GO:0052572)3.59757654
63response to interleukin-15 (GO:0070672)3.59669115
64macrophage activation (GO:0042116)3.58730258
65regulation of necroptotic process (GO:0060544)3.58369363
66negative regulation of neurotransmitter secretion (GO:0046929)3.56172002
67synaptic vesicle maturation (GO:0016188)3.52418067
68positive T cell selection (GO:0043368)3.52022751
69leukocyte aggregation (GO:0070486)3.50485582
70positive regulation of cellular amine metabolic process (GO:0033240)3.50084018
71locomotory exploration behavior (GO:0035641)3.49750555
72neuronal action potential propagation (GO:0019227)3.49145862
73regulation of B cell differentiation (GO:0045577)3.44031843
74pyrimidine nucleobase catabolic process (GO:0006208)3.43099524
75transmission of nerve impulse (GO:0019226)3.40846834
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39718984
77hemoglobin metabolic process (GO:0020027)3.39210182
78neutrophil activation (GO:0042119)3.38523291
79glycerophospholipid catabolic process (GO:0046475)3.37647510
80negative regulation of leukocyte mediated immunity (GO:0002704)3.37492548
81response to host (GO:0075136)3.32894094
82response to host defenses (GO:0052200)3.32894094
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32894094
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.32235902
85ionotropic glutamate receptor signaling pathway (GO:0035235)3.31158831
86response to peptidoglycan (GO:0032494)3.30866150
87heme biosynthetic process (GO:0006783)3.30378038
88regulation of platelet aggregation (GO:0090330)3.30351673
89glycine transport (GO:0015816)3.29840263
90respiratory burst (GO:0045730)3.28776835
91myeloid leukocyte mediated immunity (GO:0002444)3.27931792
92postsynaptic membrane organization (GO:0001941)3.25293042
93substantia nigra development (GO:0021762)3.24805234
94myeloid cell activation involved in immune response (GO:0002275)3.22987735
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20986060
96dendrite morphogenesis (GO:0048813)3.19650094
97detection of biotic stimulus (GO:0009595)3.18928796
98magnesium ion transport (GO:0015693)3.18197926
99regulation of granulocyte differentiation (GO:0030852)3.17841154
100creatine metabolic process (GO:0006600)3.16260468
101erythrocyte development (GO:0048821)3.16117136
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12756876
103adult walking behavior (GO:0007628)3.12163835
104neurotransmitter uptake (GO:0001504)3.12079041
105mannosylation (GO:0097502)3.11171019
106T cell migration (GO:0072678)3.10316385
107cellular response to interleukin-15 (GO:0071350)3.09074017
108GPI anchor biosynthetic process (GO:0006506)3.08388830
109T cell selection (GO:0045058)3.06006265
110negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05828736
111positive regulation of receptor recycling (GO:0001921)3.04584493
112granulocyte activation (GO:0036230)3.04372246
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04092325
114regulation of collateral sprouting (GO:0048670)3.03302568
115regulation of mast cell degranulation (GO:0043304)3.02847047
116negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.02444808
117regulation of alpha-beta T cell proliferation (GO:0046640)3.01690749
118peptidyl-cysteine modification (GO:0018198)3.00078160
119regulation of interferon-beta biosynthetic process (GO:0045357)2.99738252
120amino acid import (GO:0043090)2.99365989
121negative regulation of necroptotic process (GO:0060546)2.98242996
122antigen processing and presentation via MHC class Ib (GO:0002475)2.97820995
123membrane tubulation (GO:0097320)2.97483782
124myeloid cell development (GO:0061515)2.97230145
125dendritic spine morphogenesis (GO:0060997)2.97148203
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.96558132
127gas transport (GO:0015669)2.95867618
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93432404
129drug transmembrane transport (GO:0006855)2.92496683
130GPI anchor metabolic process (GO:0006505)2.92111695
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89325711
132immunoglobulin mediated immune response (GO:0016064)2.88798521
133negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87422320
134heme metabolic process (GO:0042168)2.85873220
135chaperone-mediated protein transport (GO:0072321)2.85452966
136negative regulation of axonogenesis (GO:0050771)2.85271320
137positive regulation of membrane potential (GO:0045838)2.84489408
138thymic T cell selection (GO:0045061)2.83908135
139vocalization behavior (GO:0071625)2.83659504
140type I interferon signaling pathway (GO:0060337)2.82468403
141cellular response to type I interferon (GO:0071357)2.82468403
142porphyrin-containing compound biosynthetic process (GO:0006779)2.81933290
143neuronal ion channel clustering (GO:0045161)2.81097214
144cholesterol biosynthetic process (GO:0006695)2.81077077
145leukocyte degranulation (GO:0043299)2.80607566
146response to type I interferon (GO:0034340)2.80111400
147megakaryocyte development (GO:0035855)2.80031829
148neuron remodeling (GO:0016322)2.78063494
149regulation of mast cell activation involved in immune response (GO:0033006)2.76906259
150neuron recognition (GO:0008038)2.76717817
151negative regulation of T-helper cell differentiation (GO:0045623)2.76348295
152negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76348295
153lymphoid progenitor cell differentiation (GO:0002320)2.72780372
154regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72124391
155cyclic nucleotide catabolic process (GO:0009214)2.72018862
156leukocyte migration involved in inflammatory response (GO:0002523)2.70006462
157regulation of regulatory T cell differentiation (GO:0045589)2.69623818
158exploration behavior (GO:0035640)2.69583199
159photoreceptor cell differentiation (GO:0046530)2.69424503
160eye photoreceptor cell differentiation (GO:0001754)2.69424503
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69075022
162mitochondrion transport along microtubule (GO:0047497)2.69075022
163protein localization to synapse (GO:0035418)2.69037596
164glutamate receptor signaling pathway (GO:0007215)2.68692487
165defense response to protozoan (GO:0042832)2.67923928
166response to muramyl dipeptide (GO:0032495)2.67019100
167regulation of leukocyte degranulation (GO:0043300)2.66102857
168negative regulation of adaptive immune response (GO:0002820)2.65680777
169preassembly of GPI anchor in ER membrane (GO:0016254)2.64884054
170synaptic transmission, glutamatergic (GO:0035249)2.64821149
171astrocyte development (GO:0014002)2.64045311
172tetrapyrrole biosynthetic process (GO:0033014)2.63560247
173positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63473135
174L-phenylalanine catabolic process (GO:0006559)2.63031557
175erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.63031557
176positive regulation of synapse assembly (GO:0051965)2.62948111
177import into cell (GO:0098657)2.62136110
178negative regulation of axon extension (GO:0030517)2.61504873
179glutathione biosynthetic process (GO:0006750)2.61305501
180negative regulation of protein localization to cell surface (GO:2000009)2.60445435
181response to mercury ion (GO:0046689)2.60326223
182membrane hyperpolarization (GO:0060081)2.59694950
183regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59154445
184regulation of pigment cell differentiation (GO:0050932)2.55811374
185protein palmitoylation (GO:0018345)2.55026147
186nonribosomal peptide biosynthetic process (GO:0019184)2.54034838
187regulation of axon regeneration (GO:0048679)2.53641797
188regulation of neuron projection regeneration (GO:0070570)2.53641797
189C-terminal protein lipidation (GO:0006501)2.53607338
190sterol biosynthetic process (GO:0016126)2.53464129
191gamma-aminobutyric acid transport (GO:0015812)2.52807010
192auditory behavior (GO:0031223)2.51188966
193isoprenoid biosynthetic process (GO:0008299)2.51047004
194activated T cell proliferation (GO:0050798)2.50919396
195positive regulation of action potential (GO:0045760)2.48387716
196regulation of glutamate receptor signaling pathway (GO:1900449)2.47110163
197myelination in peripheral nervous system (GO:0022011)2.44787788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.91803239
2EZH2_22144423_ChIP-Seq_EOC_Human4.63122800
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.09387065
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91211443
5GBX2_23144817_ChIP-Seq_PC3_Human3.51933453
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.23045877
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20490713
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15646378
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99175983
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88145250
11SCL_19346495_ChIP-Seq_HPC-7_Human2.83252962
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.77843740
13TAF15_26573619_Chip-Seq_HEK293_Human2.73412903
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73295931
15MYB_26560356_Chip-Seq_TH2_Human2.72318369
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68546546
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64667457
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64354266
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62419701
20SPI1_23547873_ChIP-Seq_NB4_Human2.59060986
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.48756969
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45983177
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42474779
24MYB_26560356_Chip-Seq_TH1_Human2.37816184
25SPI1_23127762_ChIP-Seq_K562_Human2.36544697
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.35104878
27MAF_26560356_Chip-Seq_TH1_Human2.33895143
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29945023
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27476606
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26512268
31VDR_21846776_ChIP-Seq_THP-1_Human2.26498105
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.24949216
33MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24455753
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19773989
35* VDR_24763502_ChIP-Seq_THP-1_Human2.18928147
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17908993
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16642023
38MYC_22102868_ChIP-Seq_BL_Human2.13756845
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13429070
40RUNX1_22412390_ChIP-Seq_EML_Mouse2.12798570
41AR_21572438_ChIP-Seq_LNCaP_Human2.10540756
42UTX_26944678_Chip-Seq_JUKART_Human2.07306158
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06518440
44EZH2_27294783_Chip-Seq_ESCs_Mouse2.02956442
45REST_21632747_ChIP-Seq_MESCs_Mouse2.02136656
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01875662
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01205501
48EGR1_19374776_ChIP-ChIP_THP-1_Human2.00745318
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99056463
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96397831
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95580492
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94137762
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.93510210
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93013675
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90584777
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90584777
57GATA3_27048872_Chip-Seq_THYMUS_Human1.90209208
58TCF7_22412390_ChIP-Seq_EML_Mouse1.85877103
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.84756418
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83179251
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82634536
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81138890
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80704760
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80230622
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.77712798
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77693965
67IGF1R_20145208_ChIP-Seq_DFB_Human1.76135573
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74915911
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74425423
70* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.73824031
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73268384
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66968654
73DROSHA_22980978_ChIP-Seq_HELA_Human1.66802689
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.64602237
75GATA1_19941826_ChIP-Seq_K562_Human1.64321756
76ER_23166858_ChIP-Seq_MCF-7_Human1.63857909
77MAF_26560356_Chip-Seq_TH2_Human1.61923733
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61556333
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.60330278
80* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56988418
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56880530
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52673218
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.52525193
84* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51458396
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48880934
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.47880805
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46585172
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45621006
89PU_27001747_Chip-Seq_BMDM_Mouse1.44863602
90KDM2B_26808549_Chip-Seq_DND41_Human1.43291016
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41187179
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40568215
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40426054
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34364738
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34259466
96VDR_24787735_ChIP-Seq_THP-1_Human1.33958966
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32757939
98GATA1_22025678_ChIP-Seq_K562_Human1.32685483
99NCOR1_26117541_ChIP-Seq_K562_Human1.31728762
100GATA3_26560356_Chip-Seq_TH2_Human1.31714707
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30265468
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28431904
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.28348922
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23620286
105P300_19829295_ChIP-Seq_ESCs_Human1.23451125
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23435802
107* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23116679
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21737090
109TFEB_21752829_ChIP-Seq_HELA_Human1.20344418
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19719546
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18713744
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17833288
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17108780
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16883651
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15269399
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.15006557
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14910339
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13980121
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.13780192
120RUNX_20019798_ChIP-Seq_JUKART_Human1.12174586
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10089030
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10063497
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09471601
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08659688
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07699894
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.07643391
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.07101577
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06892222
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06794775
130EOMES_21245162_ChIP-Seq_HESCs_Human1.06357767
131ERG_21242973_ChIP-ChIP_JURKAT_Human1.05875417
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04183195
133* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04102819
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03879537
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03077026
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02971547
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02001744
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01456396
139GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01038617
140GATA2_19941826_ChIP-Seq_K562_Human1.00854246
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97563667
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97267531
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96990658
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96743503
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.96058404
146* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95913286
147CIITA_25753668_ChIP-Seq_RAJI_Human0.95523492
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94959550
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94820864
150SMAD4_21799915_ChIP-Seq_A2780_Human0.94696103
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94430988
152RNF2_27304074_Chip-Seq_NSC_Mouse0.94259618
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93989427
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93885760
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.93427546
156HTT_18923047_ChIP-ChIP_STHdh_Human0.93356280
157IRF1_19129219_ChIP-ChIP_H3396_Human0.92581089
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91695451
159MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90966501
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89109906
161FUS_26573619_Chip-Seq_HEK293_Human0.88173863
162* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87002153
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.86178789
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85260768
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83592641
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83432196
167TET1_21490601_ChIP-Seq_MESCs_Mouse0.83125171
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81786116
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81467487
170ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80646069
171LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80302580
172GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80109463
173LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79833953
174GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79568996
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78261090
176TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78083359
177* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77916875
178NANOG_18555785_Chip-Seq_ESCs_Mouse0.76850564
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.76614978
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76145763
181SMRT_27268052_Chip-Seq_Bcells_Human0.75384448
182ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73590366
183FOXO3_23340844_ChIP-Seq_DLD1_Human0.73373767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.12522848
2MP0004147_increased_porphyrin_level3.84434017
3MP0003880_abnormal_central_pattern3.69412236
4MP0003724_increased_susceptibility_to3.53873149
5MP0004859_abnormal_synaptic_plasticity3.29901734
6MP0001835_abnormal_antigen_presentation3.26085835
7MP0003303_peritoneal_inflammation3.19681582
8MP0004270_analgesia3.02333844
9MP0003656_abnormal_erythrocyte_physiolo2.98973221
10MP0003436_decreased_susceptibility_to2.96279998
11MP0001529_abnormal_vocalization2.94439016
12MP0005464_abnormal_platelet_physiology2.81593440
13MP0005171_absent_coat_pigmentation2.77538110
14MP0003763_abnormal_thymus_physiology2.66595724
15MP0000569_abnormal_digit_pigmentation2.62722688
16MP0002272_abnormal_nervous_system2.62136567
17MP0003635_abnormal_synaptic_transmissio2.57263391
18MP0004885_abnormal_endolymph2.55712743
19MP0003329_amyloid_beta_deposits2.55197404
20MP0005423_abnormal_somatic_nervous2.51956552
21MP0002064_seizures2.51636248
22MP0001800_abnormal_humoral_immune2.48316422
23MP0002419_abnormal_innate_immunity2.42694316
24MP0000685_abnormal_immune_system2.38081203
25MP0005409_darkened_coat_color2.37338280
26MP0001486_abnormal_startle_reflex2.35776329
27MP0009745_abnormal_behavioral_response2.34097337
28MP0005025_abnormal_response_to2.33647701
29MP0004142_abnormal_muscle_tone2.26631707
30MP0003300_gastrointestinal_ulcer2.23369084
31MP0005000_abnormal_immune_tolerance2.22078268
32MP0005451_abnormal_body_composition2.17753299
33MP0005671_abnormal_response_to2.17291712
34MP0002420_abnormal_adaptive_immunity2.15281086
35MP0002723_abnormal_immune_serum2.12307519
36MP0002398_abnormal_bone_marrow2.12231131
37MP0001819_abnormal_immune_cell2.12174243
38MP0001905_abnormal_dopamine_level2.09939689
39MP0009785_altered_susceptibility_to2.09644051
40MP0001790_abnormal_immune_system2.05593404
41MP0005387_immune_system_phenotype2.05593404
42MP0002452_abnormal_antigen_presenting2.03087273
43MP0004043_abnormal_pH_regulation2.01786769
44MP0001348_abnormal_lacrimal_gland1.99033888
45MP0001545_abnormal_hematopoietic_system1.94267853
46MP0005397_hematopoietic_system_phenotyp1.94267853
47MP0003690_abnormal_glial_cell1.93046369
48MP0002405_respiratory_system_inflammati1.90549557
49MP0000778_abnormal_nervous_system1.90159669
50MP0002572_abnormal_emotion/affect_behav1.90060817
51MP0002734_abnormal_mechanical_nocicepti1.89631232
52MP0002063_abnormal_learning/memory/cond1.85599311
53MP0006082_CNS_inflammation1.84145453
54MP0009046_muscle_twitch1.80415971
55MP0000689_abnormal_spleen_morphology1.80247091
56MP0002132_abnormal_respiratory_system1.79521769
57MP0008569_lethality_at_weaning1.78459956
58MP0001968_abnormal_touch/_nociception1.78318931
59MP0002722_abnormal_immune_system1.78225164
60MP0000716_abnormal_immune_system1.78064469
61MP0003634_abnormal_glial_cell1.75882969
62MP0004742_abnormal_vestibular_system1.72320527
63MP0004381_abnormal_hair_follicle1.67960163
64MP0003191_abnormal_cellular_cholesterol1.64791987
65MP0005645_abnormal_hypothalamus_physiol1.63375643
66MP0002166_altered_tumor_susceptibility1.62694252
67MP0002733_abnormal_thermal_nociception1.62636234
68MP0002229_neurodegeneration1.61332796
69MP0000703_abnormal_thymus_morphology1.61187092
70MP0003866_abnormal_defecation1.61096670
71MP0009333_abnormal_splenocyte_physiolog1.59675653
72MP0002735_abnormal_chemical_nociception1.58444090
73MP0002429_abnormal_blood_cell1.58362628
74MP0002067_abnormal_sensory_capabilities1.56964471
75MP0001970_abnormal_pain_threshold1.54010701
76MP0002822_catalepsy1.52774030
77MP0005075_abnormal_melanosome_morpholog1.52711356
78MP0002148_abnormal_hypersensitivity_rea1.51019458
79MP0000955_abnormal_spinal_cord1.48758053
80MP0004947_skin_inflammation1.48107726
81MP0004883_abnormal_blood_vessel1.47130985
82MP0004808_abnormal_hematopoietic_stem1.44413010
83MP0004924_abnormal_behavior1.42861182
84MP0005386_behavior/neurological_phenoty1.42861182
85MP0001845_abnormal_inflammatory_respons1.41874722
86MP0001485_abnormal_pinna_reflex1.40964215
87MP0003136_yellow_coat_color1.40410244
88MP0003828_pulmonary_edema1.39795931
89MP0005058_abnormal_lysosome_morphology1.38040775
90MP0003172_abnormal_lysosome_physiology1.37720586
91MP0002557_abnormal_social/conspecific_i1.37010281
92MP0003632_abnormal_nervous_system1.36927070
93MP0009278_abnormal_bone_marrow1.36210718
94MP0001533_abnormal_skeleton_physiology1.35459398
95MP0001440_abnormal_grooming_behavior1.34967632
96MP0010155_abnormal_intestine_physiology1.34376375
97MP0000604_amyloidosis1.32270096
98MP0005310_abnormal_salivary_gland1.30959784
99MP0002066_abnormal_motor_capabilities/c1.29342927
100MP0002736_abnormal_nociception_after1.29234041
101MP0001188_hyperpigmentation1.28421120
102MP0003631_nervous_system_phenotype1.28272461
103MP0001851_eye_inflammation1.26540916
104MP0002882_abnormal_neuron_morphology1.24839903
105MP0005646_abnormal_pituitary_gland1.23632792
106MP0000858_altered_metastatic_potential1.22251700
107MP0003633_abnormal_nervous_system1.22239417
108MP0005174_abnormal_tail_pigmentation1.22142060
109MP0005410_abnormal_fertilization1.21855554
110MP0002139_abnormal_hepatobiliary_system1.17017471
111MP0002184_abnormal_innervation1.16692584
112MP0003221_abnormal_cardiomyocyte_apopto1.16334958
113MP0004811_abnormal_neuron_physiology1.15208425
114MP0003787_abnormal_imprinting1.11033315
115MP0003879_abnormal_hair_cell1.10311350
116MP0000015_abnormal_ear_pigmentation1.09912380
117MP0001963_abnormal_hearing_physiology1.09775547
118MP0000462_abnormal_digestive_system1.08711904
119MP0002095_abnormal_skin_pigmentation1.08665897
120MP0001501_abnormal_sleep_pattern1.08394328
121MP0008469_abnormal_protein_level1.07223954
122MP0005379_endocrine/exocrine_gland_phen1.05493739
123MP0009764_decreased_sensitivity_to1.03285056
124MP0005164_abnormal_response_to1.02976544
125MP0008872_abnormal_physiological_respon1.01804534
126MP0000371_diluted_coat_color1.00892137
127MP0000631_abnormal_neuroendocrine_gland1.00728297
128MP0008057_abnormal_DNA_replication0.98764444
129MP0004134_abnormal_chest_morphology0.96996527
130MP0002332_abnormal_exercise_endurance0.96837617
131MP0003806_abnormal_nucleotide_metabolis0.96021492
132MP0002006_tumorigenesis0.90510265
133MP0009763_increased_sensitivity_to0.90287444
134MP0009379_abnormal_foot_pigmentation0.88375432
135MP0001853_heart_inflammation0.87106920
136MP0003195_calcinosis0.85817989
137MP0005408_hypopigmentation0.84701861
138MP0008260_abnormal_autophagy0.84459628
139MP0002752_abnormal_somatic_nervous0.84268890
140MP0002998_abnormal_bone_remodeling0.83344418
141MP0005584_abnormal_enzyme/coenzyme_acti0.83306250
142MP0002019_abnormal_tumor_incidence0.81566187
143MP0001502_abnormal_circadian_rhythm0.81038614
144MP0003868_abnormal_feces_composition0.80061443
145MP0005636_abnormal_mineral_homeostasis0.79818444
146MP0005535_abnormal_body_temperature0.79648424
147MP0009765_abnormal_xenobiotic_induced0.79537985
148MP0002152_abnormal_brain_morphology0.79150361
149MP0000465_gastrointestinal_hemorrhage0.79082529
150MP0003186_abnormal_redox_activity0.78276655
151MP0002938_white_spotting0.77502678
152MP0002396_abnormal_hematopoietic_system0.74897452
153MP0008004_abnormal_stomach_pH0.73571957
154MP0002069_abnormal_eating/drinking_beha0.72436404
155MP0001663_abnormal_digestive_system0.72174133
156MP0008874_decreased_physiological_sensi0.71297422
157MP0005551_abnormal_eye_electrophysiolog0.70303548
158MP0005621_abnormal_cell_physiology0.69827021
159MP0002638_abnormal_pupillary_reflex0.69402934
160MP0001915_intracranial_hemorrhage0.67793379
161MP0003183_abnormal_peptide_metabolism0.67522686
162MP0004484_altered_response_of0.67064405
163MP0000609_abnormal_liver_physiology0.66465226
164MP0006036_abnormal_mitochondrial_physio0.62222236
165MP0003075_altered_response_to0.61255657
166MP0005083_abnormal_biliary_tract0.61134679
167MP0000343_altered_response_to0.61084805
168MP0003698_abnormal_male_reproductive0.60964567
169MP0006276_abnormal_autonomic_nervous0.60621898
170MP0003091_abnormal_cell_migration0.60082568
171MP0006054_spinal_hemorrhage0.59685511
172MP0000249_abnormal_blood_vessel0.58414743
173MP0004130_abnormal_muscle_cell0.58173737
174MP0005376_homeostasis/metabolism_phenot0.57588669
175MP0001765_abnormal_ion_homeostasis0.57442971
176MP0006035_abnormal_mitochondrial_morpho0.57147318
177MP0000747_muscle_weakness0.56331350
178MP0000372_irregular_coat_pigmentation0.55079608
179MP0000026_abnormal_inner_ear0.54807597
180MP0005384_cellular_phenotype0.54269309

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.02497939
2Eczematoid dermatitis (HP:0000976)5.54666035
3Recurrent bacterial skin infections (HP:0005406)5.52012843
4Recurrent abscess formation (HP:0002722)5.31595207
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.56845705
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.52155879
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.52155879
8Myositis (HP:0100614)4.35333337
9Cerebral hypomyelination (HP:0006808)4.22526558
10Prolonged bleeding time (HP:0003010)4.21190321
11Neurofibrillary tangles (HP:0002185)4.21122816
12Peripheral hypomyelination (HP:0007182)4.16321130
13T lymphocytopenia (HP:0005403)4.14694352
14Microcytic anemia (HP:0001935)4.06361054
15Gastrointestinal infarctions (HP:0005244)4.06337222
16Orchitis (HP:0100796)4.02023064
17Abnormality of the corticospinal tract (HP:0002492)4.01271029
18Hypochromic anemia (HP:0001931)4.01070818
19Abnormality of macrophages (HP:0004311)3.97268017
20Gingival bleeding (HP:0000225)3.95615495
21Elevated erythrocyte sedimentation rate (HP:0003565)3.92649444
22Abnormality of T cell number (HP:0011839)3.89236615
23Recurrent fungal infections (HP:0002841)3.84913050
24Retrobulbar optic neuritis (HP:0100654)3.82853206
25Optic neuritis (HP:0100653)3.82853206
26Recurrent gram-negative bacterial infections (HP:0005420)3.81118559
27Stomatitis (HP:0010280)3.72647789
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.71008498
29Ankle clonus (HP:0011448)3.67630591
30Spontaneous hematomas (HP:0007420)3.63375283
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.60339239
32Recurrent skin infections (HP:0001581)3.54726357
33Retinal dysplasia (HP:0007973)3.53761766
34Supranuclear gaze palsy (HP:0000605)3.46956084
35Epistaxis (HP:0000421)3.46843390
36Metabolic alkalosis (HP:0200114)3.45815660
37Abnormal auditory evoked potentials (HP:0006958)3.45010691
38Spastic gait (HP:0002064)3.40032482
39Increased circulating renin level (HP:0000848)3.35864979
40Myokymia (HP:0002411)3.34040237
41Gingivitis (HP:0000230)3.32055781
42Urticaria (HP:0001025)3.31582627
43Obstructive lung disease (HP:0006536)3.30915054
44Chronic obstructive pulmonary disease (HP:0006510)3.30915054
45Type II lissencephaly (HP:0007260)3.25507874
46Mediastinal lymphadenopathy (HP:0100721)3.24285740
47* Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.23845544
48Hypokalemic alkalosis (HP:0001949)3.22752270
49Hypomagnesemia (HP:0002917)3.20804497
50Meningitis (HP:0001287)3.17819358
51Polycythemia (HP:0001901)3.17394538
52Onion bulb formation (HP:0003383)3.16668323
53Encephalitis (HP:0002383)3.13372495
54Recurrent viral infections (HP:0004429)3.10319586
55Abnormality of T cells (HP:0002843)3.04446827
56Recurrent cutaneous fungal infections (HP:0011370)2.98469696
57Chronic mucocutaneous candidiasis (HP:0002728)2.98469696
58Petechiae (HP:0000967)2.96842639
59Keratoconjunctivitis sicca (HP:0001097)2.93198981
60Intention tremor (HP:0002080)2.93016235
61CNS hypomyelination (HP:0003429)2.91019190
62Cellulitis (HP:0100658)2.87818430
63Vasculitis (HP:0002633)2.86715752
64Chest pain (HP:0100749)2.84796684
65Leukocytosis (HP:0001974)2.84017662
66Peritonitis (HP:0002586)2.83944684
67Abnormality of magnesium homeostasis (HP:0004921)2.80622481
68Inflammation of the large intestine (HP:0002037)2.78602311
69Akinesia (HP:0002304)2.78113095
70Spastic paraparesis (HP:0002313)2.77607555
71White forelock (HP:0002211)2.74839791
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71260786
73Cerebral inclusion bodies (HP:0100314)2.70782939
74Gastrointestinal inflammation (HP:0004386)2.70652432
75Arterial thrombosis (HP:0004420)2.69465188
76Limb dystonia (HP:0002451)2.69154898
77Abnormal platelet volume (HP:0011876)2.65947934
78Segmental peripheral demyelination/remyelination (HP:0003481)2.65735405
79Leukodystrophy (HP:0002415)2.65373349
80Keratoconjunctivitis (HP:0001096)2.63963422
81Dysmetria (HP:0001310)2.63636331
82Sensory axonal neuropathy (HP:0003390)2.62193489
83Patchy hypopigmentation of hair (HP:0011365)2.61689574
84Granulocytopenia (HP:0001913)2.59889990
85Cholelithiasis (HP:0001081)2.58205343
86Osteomyelitis (HP:0002754)2.49637953
87Morphological abnormality of the inner ear (HP:0011390)2.49543083
88Episodic fever (HP:0001954)2.45290428
89Panhypogammaglobulinemia (HP:0003139)2.45194832
90Focal motor seizures (HP:0011153)2.45160334
91Acute hepatic failure (HP:0006554)2.43579663
92Increased IgE level (HP:0003212)2.41228829
93Autoimmune hemolytic anemia (HP:0001890)2.41179932
94Broad-based gait (HP:0002136)2.40951794
95Orthostatic hypotension (HP:0001278)2.40360882
96Alacrima (HP:0000522)2.39095348
97Scanning speech (HP:0002168)2.37253850
98Parakeratosis (HP:0001036)2.36919097
99Pustule (HP:0200039)2.35987187
100Insidious onset (HP:0003587)2.35582852
101Termporal pattern (HP:0011008)2.35582852
102Colitis (HP:0002583)2.34237594
103Viral hepatitis (HP:0006562)2.33311560
104Chronic otitis media (HP:0000389)2.32517909
105Abnormal drinking behavior (HP:0030082)2.32065469
106Polydipsia (HP:0001959)2.32065469
107Choreoathetosis (HP:0001266)2.31918592
108Anorexia (HP:0002039)2.30560785
109Action tremor (HP:0002345)2.30382619
110Abnormality of iron homeostasis (HP:0011031)2.29902175
111Muscular hypotonia of the trunk (HP:0008936)2.27202358
112Abnormal gallbladder morphology (HP:0012437)2.27179675
113Abnormality of T cell physiology (HP:0011840)2.27111222
114Eosinophilia (HP:0001880)2.26198982
115Progressive inability to walk (HP:0002505)2.25709923
116Increased IgM level (HP:0003496)2.22908735
117Purpura (HP:0000979)2.21990956
118Pulmonary infiltrates (HP:0002113)2.21596033
119Hemoptysis (HP:0002105)2.19519035
120Clonus (HP:0002169)2.18867842
121Increased mean platelet volume (HP:0011877)2.18512732
122Recurrent bronchitis (HP:0002837)2.15923322
123Pulmonary embolism (HP:0002204)2.15361387
124Decreased lacrimation (HP:0000633)2.14649845
125Polyuria (HP:0000103)2.14301993
126Ocular albinism (HP:0001107)2.14125026
127Increased serum ferritin (HP:0003281)2.13727017
128Paraparesis (HP:0002385)2.12311940
129Fatigue (HP:0012378)2.12281211
130Abnormality of the fingertips (HP:0001211)2.12165703
131Subacute progressive viral hepatitis (HP:0006572)2.11982592
132Abnormality of the peritoneum (HP:0002585)2.11022131
133Thyroid-stimulating hormone excess (HP:0002925)2.08651866
134Abnormal hemoglobin (HP:0011902)2.08457357
135Clumsiness (HP:0002312)2.08026379
136Acanthocytosis (HP:0001927)2.06516659
137Anxiety (HP:0000739)2.05398111
138Urinary urgency (HP:0000012)2.02842661
139Poikilocytosis (HP:0004447)2.02581021
140Toxemia of pregnancy (HP:0100603)2.01874537
141Lymphopenia (HP:0001888)2.01145862
142Epileptic encephalopathy (HP:0200134)2.00967347
143Mutism (HP:0002300)2.00622337
144Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00575789
145Conjunctival telangiectasia (HP:0000524)1.99449567
146Hyperaldosteronism (HP:0000859)1.99300178
147Morphological abnormality of the pyramidal tract (HP:0002062)1.99050087
148IgM deficiency (HP:0002850)1.98423666
149Poor speech (HP:0002465)1.98299683
150Agammaglobulinemia (HP:0004432)1.97537967
151Lissencephaly (HP:0001339)1.97337237
152Hypothermia (HP:0002045)1.97196165
153Abnormal platelet function (HP:0011869)1.95721618
154Impaired platelet aggregation (HP:0003540)1.95721618
155Alkalosis (HP:0001948)1.95648194
156Abnormality of eosinophils (HP:0001879)1.94410345
157Craniofacial dystonia (HP:0012179)1.93539683
158Autoimmune thrombocytopenia (HP:0001973)1.93193485
159Hyperbilirubinemia (HP:0002904)1.92634209
160Thrombophlebitis (HP:0004418)1.92446510
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.91630030
162Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91457004
163Hypoplasia of the brainstem (HP:0002365)1.91457004
164Abnormality of transition element cation homeostasis (HP:0011030)1.91449020
165Abnormal number of erythroid precursors (HP:0012131)1.90333711
166Albinism (HP:0001022)1.89559139
167Abnormality of renin-angiotensin system (HP:0000847)1.88267884
168Premature skin wrinkling (HP:0100678)1.88116877
169Cutaneous photosensitivity (HP:0000992)1.87947975
170Abnormal urine output (HP:0012590)1.87508737
171Hyperventilation (HP:0002883)1.86531229
172Spastic tetraparesis (HP:0001285)1.85132308
173Psychosis (HP:0000709)1.84385473
174Focal dystonia (HP:0004373)1.84081564
175Delayed epiphyseal ossification (HP:0002663)1.83744990
176Progressive neurologic deterioration (HP:0002344)1.81548259
177Torticollis (HP:0000473)1.81148530
178Focal seizures (HP:0007359)1.80823172
179Megalencephaly (HP:0001355)1.80750080
180Abnormality of cells of the erythroid lineage (HP:0012130)1.79810170
181Blue irides (HP:0000635)1.79786075
182Delayed myelination (HP:0012448)1.78766362
183Renal Fanconi syndrome (HP:0001994)1.78720530
184Visual hallucinations (HP:0002367)1.78412716
185Truncal ataxia (HP:0002078)1.77464672
186Polyphagia (HP:0002591)1.76382185
187Partial agenesis of the corpus callosum (HP:0001338)1.76099186
188Absent speech (HP:0001344)1.76032694
189Lower limb muscle weakness (HP:0007340)1.72432385
190Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71897333
191Cerebellar dysplasia (HP:0007033)1.71874716
192Diaphragmatic weakness (HP:0009113)1.70679764
193Insomnia (HP:0100785)1.70647533
194Hypoplastic pelvis (HP:0008839)1.70364231
195* Rigidity (HP:0002063)1.70058960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.88341181
2RIPK44.39722787
3STK393.76936494
4OXSR13.59513297
5MARK13.48933466
6GRK63.47824899
7MAP2K33.37865069
8CDK192.88825080
9MAP4K12.84423837
10BLK2.61943353
11MAPKAPK52.48096181
12FES2.47561575
13CASK2.33287374
14PRPF4B2.22127922
15TYK22.20129231
16PKN12.20123692
17CSK2.19351822
18WNK42.19143103
19MAP3K32.16958786
20IKBKE2.12997723
21IRAK42.11696880
22CSNK1G32.09380969
23DYRK22.03389034
24JAK32.01376610
25UHMK12.00230808
26TAOK11.99015218
27MAPK131.97311324
28EPHB11.95205902
29MUSK1.89582949
30CSNK1G21.75183262
31NTRK21.74207655
32ZAP701.73789518
33ERN11.72813266
34PTK2B1.69344719
35TAOK21.68551621
36TXK1.66669127
37CSNK1A1L1.65925763
38TYRO31.54577598
39MAP3K141.53464470
40MAP3K11.51696587
41CSNK1G11.48601908
42HCK1.46444366
43MARK31.42244472
44GRK51.37759571
45WNK31.35948297
46STK41.31223618
47ICK1.29341023
48PIM11.28591652
49LYN1.28307803
50JAK21.26647332
51EPHA41.25469957
52FGFR31.24514155
53BMPR21.22929511
54TNK21.22306072
55MAP2K71.21540129
56JAK11.20415031
57CDK51.19610139
58TLK11.17850785
59IRAK21.17568786
60TEC1.14113860
61MARK21.13871508
62NEK61.13828596
63ITK1.12020196
64SGK21.09780390
65KSR21.05612745
66CAMK2B1.05577687
67SGK31.04566067
68NTRK31.03473894
69KIT1.03435652
70TBK11.01523791
71MATK1.00131080
72SGK2230.99823120
73SGK4940.99823120
74LIMK10.99255400
75LRRK20.99229171
76MINK10.99086513
77SIK20.98611503
78CLK10.98388579
79BCR0.96423825
80RAF10.94266545
81PIK3CG0.93935564
82YES10.91701896
83FGFR40.91557434
84WNK10.89535972
85VRK10.88523558
86PHKG10.88402170
87PHKG20.88402170
88NTRK10.86653000
89IKBKB0.86512781
90MAP3K50.85595238
91STK100.85180956
92FGFR20.84969686
93STK160.83625639
94PAK60.80860560
95CSF1R0.79653559
96SIK30.79627504
97PDK10.76235276
98ROCK20.74747153
99PNCK0.74017386
100IRAK10.71283238
101CAMK2G0.68874456
102MAP3K60.67629573
103PLK20.67556951
104HIPK20.67294000
105MAP3K40.67175161
106PTK60.65279423
107CDK140.64191308
108KSR10.64150401
109CAMK2D0.64116893
110NLK0.63997565
111TGFBR20.63993205
112PINK10.63082101
113BMX0.61416949
114TRPM70.61020373
115CDK120.60087956
116BMPR1B0.59676692
117CDK150.59274058
118CAMK10.59071334
119EIF2AK10.58979768
120SCYL20.58731756
121CAMK2A0.58697776
122CDK180.57553693
123FGR0.57380474
124CDK11A0.55528831
125STK380.54794088
126ERBB20.53910767
127FYN0.52960073
128PDPK10.52634103
129SYK0.52532204
130MAP3K70.51744619
131MAPK40.51689643
132CAMKK20.50666515
133MET0.50537764
134GRK70.50049683
135TESK20.47696989
136PRKCQ0.46779880
137SMG10.46155954
138DYRK1A0.45241378
139MAPK120.44138384
140PDGFRB0.43592400
141DYRK1B0.43189938
142CDK40.41914939
143DAPK20.41583294
144TRIB30.41153016
145MAP3K100.39964214
146MAPK110.39500876
147BTK0.38990906
148ADRBK20.38963034
149LCK0.38653973
150PRKCZ0.38554874
151CCNB10.38281130
152PBK0.38108712
153MAPK150.37328475
154PRKG10.37322185
155SGK10.36729100
156INSRR0.36572554
157STK110.36327496
158MAP3K110.35774478
159PRKCG0.33721055
160FLT30.33345998
161EGFR0.32791058
162TAOK30.32172099
163MAP3K120.32081849
164ACVR1B0.30064274
165PRKCH0.30041944
166CSNK1D0.29061994
167MAP3K20.28847165
168GSK3A0.28528434
169RET0.28349394
170MAP3K130.27619671

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.09229843
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.09854467
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06617254
4Leishmaniasis_Homo sapiens_hsa051402.79828226
5Fatty acid elongation_Homo sapiens_hsa000622.76420820
6Osteoclast differentiation_Homo sapiens_hsa043802.70841356
7Steroid biosynthesis_Homo sapiens_hsa001002.70119914
8B cell receptor signaling pathway_Homo sapiens_hsa046622.60313281
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60141960
10Sulfur metabolism_Homo sapiens_hsa009202.52928834
11Protein export_Homo sapiens_hsa030602.40390812
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.29387780
13Primary immunodeficiency_Homo sapiens_hsa053402.26717167
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.20711988
15Ether lipid metabolism_Homo sapiens_hsa005652.19374258
16Malaria_Homo sapiens_hsa051442.17492389
17Non-small cell lung cancer_Homo sapiens_hsa052232.14420844
18Glutamatergic synapse_Homo sapiens_hsa047242.08937753
19Acute myeloid leukemia_Homo sapiens_hsa052212.02690933
20Staphylococcus aureus infection_Homo sapiens_hsa051501.98002368
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97193637
22T cell receptor signaling pathway_Homo sapiens_hsa046601.96643355
23GABAergic synapse_Homo sapiens_hsa047271.95072892
24Measles_Homo sapiens_hsa051621.94694906
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.93398670
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.89837200
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89381428
28Tuberculosis_Homo sapiens_hsa051521.84587632
29Allograft rejection_Homo sapiens_hsa053301.83281069
30Cocaine addiction_Homo sapiens_hsa050301.76717518
31Autoimmune thyroid disease_Homo sapiens_hsa053201.76673161
32Nicotine addiction_Homo sapiens_hsa050331.76422667
33Axon guidance_Homo sapiens_hsa043601.75369176
34Graft-versus-host disease_Homo sapiens_hsa053321.75052116
35Folate biosynthesis_Homo sapiens_hsa007901.73242985
36Hematopoietic cell lineage_Homo sapiens_hsa046401.72907139
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72315982
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72055130
39Serotonergic synapse_Homo sapiens_hsa047261.70055780
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68079672
41Pancreatic cancer_Homo sapiens_hsa052121.62521948
42Chemokine signaling pathway_Homo sapiens_hsa040621.60422063
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57642685
44Nitrogen metabolism_Homo sapiens_hsa009101.57308681
45Butanoate metabolism_Homo sapiens_hsa006501.56223632
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.56212952
47Morphine addiction_Homo sapiens_hsa050321.56104999
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54417197
49Oxidative phosphorylation_Homo sapiens_hsa001901.52521637
50Platelet activation_Homo sapiens_hsa046111.51855344
51Parkinsons disease_Homo sapiens_hsa050121.51473537
52Circadian entrainment_Homo sapiens_hsa047131.50763415
53Chronic myeloid leukemia_Homo sapiens_hsa052201.49875253
54Toxoplasmosis_Homo sapiens_hsa051451.49581321
55Influenza A_Homo sapiens_hsa051641.48441024
56Synaptic vesicle cycle_Homo sapiens_hsa047211.46987302
57Herpes simplex infection_Homo sapiens_hsa051681.46276121
58Hepatitis B_Homo sapiens_hsa051611.43362553
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39944324
60Sphingolipid metabolism_Homo sapiens_hsa006001.37797295
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36568006
62Dopaminergic synapse_Homo sapiens_hsa047281.35567143
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.32286853
64Amphetamine addiction_Homo sapiens_hsa050311.32227472
65Legionellosis_Homo sapiens_hsa051341.31492624
66Apoptosis_Homo sapiens_hsa042101.26008499
67Long-term depression_Homo sapiens_hsa047301.25934233
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23897459
69TNF signaling pathway_Homo sapiens_hsa046681.23252141
70Gastric acid secretion_Homo sapiens_hsa049711.22707833
71Antigen processing and presentation_Homo sapiens_hsa046121.22416543
72Type I diabetes mellitus_Homo sapiens_hsa049401.22299825
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.21936336
74Hepatitis C_Homo sapiens_hsa051601.20673550
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19391541
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17886529
77Collecting duct acid secretion_Homo sapiens_hsa049661.16140520
78Sulfur relay system_Homo sapiens_hsa041221.15825602
79African trypanosomiasis_Homo sapiens_hsa051431.15797505
80Alzheimers disease_Homo sapiens_hsa050101.15462646
81Prolactin signaling pathway_Homo sapiens_hsa049171.14741375
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14216340
83Endometrial cancer_Homo sapiens_hsa052131.13547267
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13110713
85Alcoholism_Homo sapiens_hsa050341.12854481
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11682601
87Olfactory transduction_Homo sapiens_hsa047401.10279019
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09691602
89FoxO signaling pathway_Homo sapiens_hsa040681.07820604
90VEGF signaling pathway_Homo sapiens_hsa043701.06626374
91Salivary secretion_Homo sapiens_hsa049701.04667544
92Phagosome_Homo sapiens_hsa041451.03442320
93Histidine metabolism_Homo sapiens_hsa003401.01287289
94Cholinergic synapse_Homo sapiens_hsa047251.00887903
95Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00503851
96Vitamin B6 metabolism_Homo sapiens_hsa007501.00456875
97Peroxisome_Homo sapiens_hsa041461.00226469
98Viral myocarditis_Homo sapiens_hsa054160.99787761
99Inositol phosphate metabolism_Homo sapiens_hsa005620.97701422
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.96108588
101Linoleic acid metabolism_Homo sapiens_hsa005910.95450027
102Shigellosis_Homo sapiens_hsa051310.94994060
103Viral carcinogenesis_Homo sapiens_hsa052030.94795165
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.93591080
105Arginine and proline metabolism_Homo sapiens_hsa003300.92901915
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.90899267
107Renal cell carcinoma_Homo sapiens_hsa052110.89837534
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.89105060
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87456540
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86874941
111mTOR signaling pathway_Homo sapiens_hsa041500.86450431
112Long-term potentiation_Homo sapiens_hsa047200.85113191
113Thyroid cancer_Homo sapiens_hsa052160.84368231
114Insulin secretion_Homo sapiens_hsa049110.83805645
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81342782
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77458282
117Vibrio cholerae infection_Homo sapiens_hsa051100.77064054
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77003097
119Asthma_Homo sapiens_hsa053100.76975158
120Epstein-Barr virus infection_Homo sapiens_hsa051690.76274364
121Regulation of autophagy_Homo sapiens_hsa041400.74154406
122ABC transporters_Homo sapiens_hsa020100.72479581
123Glutathione metabolism_Homo sapiens_hsa004800.72279745
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69992090
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69227449
126Colorectal cancer_Homo sapiens_hsa052100.68254591
127Renin secretion_Homo sapiens_hsa049240.67572619
128Arachidonic acid metabolism_Homo sapiens_hsa005900.67251625
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66872708
130HTLV-I infection_Homo sapiens_hsa051660.66861549
131Dorso-ventral axis formation_Homo sapiens_hsa043200.66794898
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.66536176
133Notch signaling pathway_Homo sapiens_hsa043300.66281272
134Salmonella infection_Homo sapiens_hsa051320.66144627
135Choline metabolism in cancer_Homo sapiens_hsa052310.66100958
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65440541
137Pertussis_Homo sapiens_hsa051330.64575971
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64561273
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63905937
140HIF-1 signaling pathway_Homo sapiens_hsa040660.63875188
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63369428
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61071269
143Small cell lung cancer_Homo sapiens_hsa052220.60488242
144Taste transduction_Homo sapiens_hsa047420.60117640
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59977697
146Prostate cancer_Homo sapiens_hsa052150.59128606
147Glioma_Homo sapiens_hsa052140.58156623
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57239939
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56279892
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.55757430
151Other glycan degradation_Homo sapiens_hsa005110.54618619
152Gap junction_Homo sapiens_hsa045400.54478671
153Insulin resistance_Homo sapiens_hsa049310.50717920
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48803175
155Ribosome_Homo sapiens_hsa030100.48118529
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47722224
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47294780
158Non-homologous end-joining_Homo sapiens_hsa034500.46916012
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46440642
160Metabolic pathways_Homo sapiens_hsa011000.45339317
161Endocytosis_Homo sapiens_hsa041440.45053162
162N-Glycan biosynthesis_Homo sapiens_hsa005100.44895920
163Thyroid hormone synthesis_Homo sapiens_hsa049180.44492108
164Type II diabetes mellitus_Homo sapiens_hsa049300.44030118
165Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43498515
166Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43340415
167Rheumatoid arthritis_Homo sapiens_hsa053230.43158932
168Glycosaminoglycan degradation_Homo sapiens_hsa005310.42904205
169Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41430581
170Ras signaling pathway_Homo sapiens_hsa040140.41359895
171Fatty acid metabolism_Homo sapiens_hsa012120.40930360
172Pancreatic secretion_Homo sapiens_hsa049720.40745996
173Huntingtons disease_Homo sapiens_hsa050160.40350943
174cAMP signaling pathway_Homo sapiens_hsa040240.39822825
175beta-Alanine metabolism_Homo sapiens_hsa004100.39517269
176Propanoate metabolism_Homo sapiens_hsa006400.38456240
177Phospholipase D signaling pathway_Homo sapiens_hsa040720.37358658
178Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36407405
179Bile secretion_Homo sapiens_hsa049760.35552524
180Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34606463
181Cardiac muscle contraction_Homo sapiens_hsa042600.34199043
182Calcium signaling pathway_Homo sapiens_hsa040200.33170470
183Lysosome_Homo sapiens_hsa041420.29489076
184ErbB signaling pathway_Homo sapiens_hsa040120.29330721
185Primary bile acid biosynthesis_Homo sapiens_hsa001200.27127650
186Pyruvate metabolism_Homo sapiens_hsa006200.22579376
187Ovarian steroidogenesis_Homo sapiens_hsa049130.22364477

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