FBXO8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of protein localization to cell surface (GO:2000009)7.16726947
2regulation of sarcomere organization (GO:0060297)7.03386531
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.81831303
4L-phenylalanine catabolic process (GO:0006559)6.81831303
5ribonucleoprotein complex disassembly (GO:0032988)6.77391818
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.19433970
7L-phenylalanine metabolic process (GO:0006558)6.19433970
8organelle disassembly (GO:1903008)6.06872973
9negative regulation of nitric-oxide synthase activity (GO:0051001)5.98034081
10aromatic amino acid family catabolic process (GO:0009074)5.94908856
11activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.75750704
12regulation of skeletal muscle contraction (GO:0014819)5.69790825
13positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.65124970
14negative regulation of muscle hypertrophy (GO:0014741)5.52309497
15glyoxylate metabolic process (GO:0046487)5.28481462
16cysteine metabolic process (GO:0006534)5.11968012
17tryptophan catabolic process (GO:0006569)5.11302865
18indole-containing compound catabolic process (GO:0042436)5.11302865
19indolalkylamine catabolic process (GO:0046218)5.11302865
20plasma membrane repair (GO:0001778)5.11222515
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.10026026
22tryptophan metabolic process (GO:0006568)4.88020387
23membrane raft organization (GO:0031579)4.83724564
24bile acid biosynthetic process (GO:0006699)4.74347494
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70149775
26fatty acid elongation (GO:0030497)4.69545904
27negative regulation of potassium ion transmembrane transport (GO:1901380)4.64777050
28kynurenine metabolic process (GO:0070189)4.64595198
29negative regulation of cardiac muscle hypertrophy (GO:0010614)4.60927368
30cellular ketone body metabolic process (GO:0046950)4.40262985
31primary alcohol catabolic process (GO:0034310)4.32481913
32muscle cell cellular homeostasis (GO:0046716)4.28975610
33aromatic amino acid family metabolic process (GO:0009072)4.28327601
34urea cycle (GO:0000050)4.24566674
35urea metabolic process (GO:0019627)4.24566674
36negative regulation of heart growth (GO:0061117)4.23813774
37negative regulation of cardiac muscle tissue growth (GO:0055022)4.23813774
38regulation of transforming growth factor beta2 production (GO:0032909)4.22770563
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.19909513
40lysine catabolic process (GO:0006554)4.15715430
41lysine metabolic process (GO:0006553)4.15715430
42glycerophospholipid catabolic process (GO:0046475)4.09763287
43tyrosine metabolic process (GO:0006570)4.07369600
44bile acid metabolic process (GO:0008206)4.06012510
45amine catabolic process (GO:0009310)4.00486570
46cellular biogenic amine catabolic process (GO:0042402)4.00486570
47sulfur amino acid catabolic process (GO:0000098)3.97820069
48nitrogen cycle metabolic process (GO:0071941)3.92998169
49membrane budding (GO:0006900)3.92127234
50alpha-linolenic acid metabolic process (GO:0036109)3.90118950
51complement activation, alternative pathway (GO:0006957)3.85666488
52high-density lipoprotein particle remodeling (GO:0034375)3.84755111
53urate metabolic process (GO:0046415)3.83462398
54ketone body metabolic process (GO:1902224)3.82159887
55synapsis (GO:0007129)3.81455425
56regulation of action potential (GO:0098900)3.81374684
57coenzyme catabolic process (GO:0009109)3.78557983
58alpha-amino acid catabolic process (GO:1901606)3.74372581
59indolalkylamine metabolic process (GO:0006586)3.73758024
60serine family amino acid catabolic process (GO:0009071)3.71962259
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69420444
62short-chain fatty acid metabolic process (GO:0046459)3.67597094
63regulation of protein activation cascade (GO:2000257)3.67235358
64negative regulation of fibrinolysis (GO:0051918)3.66768901
65regulation of triglyceride catabolic process (GO:0010896)3.65327756
66negative regulation of monooxygenase activity (GO:0032769)3.64516423
67protein carboxylation (GO:0018214)3.64378909
68peptidyl-glutamic acid carboxylation (GO:0017187)3.64378909
69drug catabolic process (GO:0042737)3.63697368
70regulation of cholesterol esterification (GO:0010872)3.63294947
71intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.60597036
72very long-chain fatty acid metabolic process (GO:0000038)3.60126832
73platelet dense granule organization (GO:0060155)3.59000068
74transcytosis (GO:0045056)3.58683988
75amino-acid betaine metabolic process (GO:0006577)3.57620346
76regulation of p38MAPK cascade (GO:1900744)3.56318531
77cellular amino acid catabolic process (GO:0009063)3.50525255
78homocysteine metabolic process (GO:0050667)3.50238360
79cytoplasmic microtubule organization (GO:0031122)3.49749352
80branched-chain amino acid catabolic process (GO:0009083)3.49484258
81cofactor catabolic process (GO:0051187)3.49232310
82triglyceride homeostasis (GO:0070328)3.48915786
83acylglycerol homeostasis (GO:0055090)3.48915786
84negative regulation of organelle assembly (GO:1902116)3.48215080
85regulation of fibrinolysis (GO:0051917)3.47966720
86membrane assembly (GO:0071709)3.47498574
87reverse cholesterol transport (GO:0043691)3.47412822
88positive regulation of microtubule polymerization (GO:0031116)3.46651706
89aspartate family amino acid catabolic process (GO:0009068)3.44622119
90drug transmembrane transport (GO:0006855)3.44535723
91serine family amino acid metabolic process (GO:0009069)3.43485246
92regulation of complement activation (GO:0030449)3.43429470
93acetyl-CoA metabolic process (GO:0006084)3.43346431
94intraciliary transport (GO:0042073)3.41635159
95fatty acid beta-oxidation (GO:0006635)3.39000596
96serine family amino acid biosynthetic process (GO:0009070)3.38537431
97regulation of meiosis I (GO:0060631)3.38417008
98fatty acid oxidation (GO:0019395)3.36589732
99cholesterol efflux (GO:0033344)3.35928932
100bile acid and bile salt transport (GO:0015721)3.35456222
101central nervous system myelination (GO:0022010)3.33732762
102axon ensheathment in central nervous system (GO:0032291)3.33732762
103plasma lipoprotein particle clearance (GO:0034381)3.31502264
104cellular glucuronidation (GO:0052695)3.30469909
105cholesterol biosynthetic process (GO:0006695)3.30464477
106lipid oxidation (GO:0034440)3.29640782
107fatty acid catabolic process (GO:0009062)3.29072044
108response to nitrosative stress (GO:0051409)3.29008272
109protein-lipid complex remodeling (GO:0034368)3.28911154
110macromolecular complex remodeling (GO:0034367)3.28911154
111plasma lipoprotein particle remodeling (GO:0034369)3.28911154
112phospholipid efflux (GO:0033700)3.28686531
113aldehyde catabolic process (GO:0046185)3.28678441
114postreplication repair (GO:0006301)3.28561198
115heme transport (GO:0015886)3.27978448
116benzene-containing compound metabolic process (GO:0042537)3.26953005
117positive regulation of triglyceride lipase activity (GO:0061365)3.25588128
118positive regulation of lipoprotein lipase activity (GO:0051006)3.25588128
119carboxylic acid catabolic process (GO:0046395)3.21724772
120organic acid catabolic process (GO:0016054)3.21724772
121negative regulation of cardiac muscle tissue development (GO:0055026)3.17833250
122ethanol oxidation (GO:0006069)3.17275182
123S-adenosylmethionine metabolic process (GO:0046500)3.14053802
124regulation of bile acid biosynthetic process (GO:0070857)3.12945296
125monocarboxylic acid catabolic process (GO:0072329)3.12011631
126thioester metabolic process (GO:0035383)3.11888703
127acyl-CoA metabolic process (GO:0006637)3.11888703
128opsonization (GO:0008228)3.10384425
129regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.09834636
130regulation of cholesterol metabolic process (GO:0090181)3.08939552
131very-low-density lipoprotein particle assembly (GO:0034379)3.08896587
132piRNA metabolic process (GO:0034587)3.07562306
133branched-chain amino acid metabolic process (GO:0009081)3.05188847
134pyrimidine-containing compound transmembrane transport (GO:0072531)3.04789060
135regulation of cilium movement (GO:0003352)3.02821797
136arginine metabolic process (GO:0006525)3.02691050
137glucuronate metabolic process (GO:0019585)3.02460708
138uronic acid metabolic process (GO:0006063)3.02460708
139heart process (GO:0003015)3.01126330
140heart contraction (GO:0060047)3.01126330
141ethanol metabolic process (GO:0006067)3.00978421
142regulation of protein localization to cell surface (GO:2000008)3.00283552
143polyol biosynthetic process (GO:0046173)2.96830894
144resolution of meiotic recombination intermediates (GO:0000712)2.95462942
145proteasome assembly (GO:0043248)2.91100818
146positive regulation of actin filament depolymerization (GO:0030836)2.87615124
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86894211
148histone H2A acetylation (GO:0043968)2.81154179
149mitochondrial DNA replication (GO:0006264)2.78226964
150positive regulation of TOR signaling (GO:0032008)2.77424073
151regulation of muscle hypertrophy (GO:0014743)2.76631593
152peroxisome organization (GO:0007031)2.73784674
153lipid particle organization (GO:0034389)2.71542998
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67058337
155fibroblast migration (GO:0010761)2.66586680
156valine metabolic process (GO:0006573)2.65546523
157regulation of membrane repolarization (GO:0060306)2.64779689
158negative regulation of cell size (GO:0045792)2.61162757
159ventricular cardiac muscle cell action potential (GO:0086005)2.59710656
160protein K11-linked ubiquitination (GO:0070979)2.57996717
161vascular smooth muscle contraction (GO:0014829)2.56523447
162positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.53771885
163negative regulation of organ growth (GO:0046621)2.52952959
164oxidative demethylation (GO:0070989)2.51972749
165sterol biosynthetic process (GO:0016126)2.50871647
166cullin deneddylation (GO:0010388)2.49690639
167regulation of cardioblast proliferation (GO:0003264)2.48457265
168regulation of secondary heart field cardioblast proliferation (GO:0003266)2.48457265
169regulation of calcium ion import (GO:0090279)2.45358328
170protein localization to cilium (GO:0061512)2.44764677
171phospholipid homeostasis (GO:0055091)2.44246721
172positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43409020
173mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43409020
174prenylation (GO:0097354)2.42822177
175protein prenylation (GO:0018342)2.42822177
176COPII vesicle coating (GO:0048208)2.38890934
177striated muscle atrophy (GO:0014891)2.38526573
178protein deneddylation (GO:0000338)2.36415275
179regulation of cardiac muscle hypertrophy (GO:0010611)2.34396322
180C-terminal protein lipidation (GO:0006501)2.33773003
181primary alcohol metabolic process (GO:0034308)2.33194837
182regulation of integrin-mediated signaling pathway (GO:2001044)2.32855249
183muscle atrophy (GO:0014889)2.31489026
184male meiosis I (GO:0007141)2.31086496
185adenosine metabolic process (GO:0046085)2.30357085
186epithelial cilium movement (GO:0003351)2.28807318
187positive regulation of receptor-mediated endocytosis (GO:0048260)2.28355143
188metallo-sulfur cluster assembly (GO:0031163)2.26547539
189iron-sulfur cluster assembly (GO:0016226)2.26547539
190peroxisome fission (GO:0016559)2.25873591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.73841627
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.58196187
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.48692854
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.42311001
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.40288365
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65014185
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.61078373
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.37370821
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29612017
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.11076431
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08466588
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.60053746
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59506215
14ELK1_19687146_ChIP-ChIP_HELA_Human2.55575548
15ZNF274_21170338_ChIP-Seq_K562_Hela2.26378079
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13515270
17TAF15_26573619_Chip-Seq_HEK293_Human2.13400975
18KAP1_22055183_ChIP-Seq_ESCs_Mouse2.10581561
19GBX2_23144817_ChIP-Seq_PC3_Human2.06640317
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01079686
21FUS_26573619_Chip-Seq_HEK293_Human1.83698970
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80118414
23HTT_18923047_ChIP-ChIP_STHdh_Human1.76659654
24EWS_26573619_Chip-Seq_HEK293_Human1.74474257
25VDR_22108803_ChIP-Seq_LS180_Human1.73594692
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73376189
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71679332
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70394856
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62236298
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62155549
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62112480
32* EST1_17652178_ChIP-ChIP_JURKAT_Human1.62087032
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58489111
34SMAD4_21799915_ChIP-Seq_A2780_Human1.57887256
35P300_19829295_ChIP-Seq_ESCs_Human1.55348363
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52867659
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.51333069
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49911500
39* VDR_23849224_ChIP-Seq_CD4+_Human1.49553059
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46672505
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.45680125
42GATA1_22025678_ChIP-Seq_K562_Human1.44697268
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43991015
44* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43896147
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41474640
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40453742
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40262103
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39801190
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37730149
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34706297
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32926330
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30445776
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30176040
54P53_22387025_ChIP-Seq_ESCs_Mouse1.29190423
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.27367292
56* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27306378
57BCAT_22108803_ChIP-Seq_LS180_Human1.26866540
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25154377
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24881512
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24615033
61ER_23166858_ChIP-Seq_MCF-7_Human1.24527770
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23456764
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23456764
64TP53_18474530_ChIP-ChIP_U2OS_Human1.22973034
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22922012
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.22911839
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21970560
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21428825
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.20138606
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19179557
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18760507
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18537503
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17845471
74* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17463451
75CJUN_26792858_Chip-Seq_BT549_Human1.17177006
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.16311182
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.14594610
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14548859
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13736183
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11666043
81STAT3_23295773_ChIP-Seq_U87_Human1.10507958
82* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10498723
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.10478090
84IGF1R_20145208_ChIP-Seq_DFB_Human1.09963635
85IRF1_19129219_ChIP-ChIP_H3396_Human1.09704916
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.09559198
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08973683
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08458010
89CDX2_22108803_ChIP-Seq_LS180_Human1.06286021
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.06273678
91FOXA1_25552417_ChIP-Seq_VCAP_Human1.06224924
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05794783
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.05490176
94* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05134074
95AR_25329375_ChIP-Seq_VCAP_Human1.04763824
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.04108573
97ERG_20517297_ChIP-Seq_VCAP_Human1.03610810
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03544611
99NANOG_19829295_ChIP-Seq_ESCs_Human1.02881761
100SOX2_19829295_ChIP-Seq_ESCs_Human1.02881761
101BRD4_25478319_ChIP-Seq_HGPS_Human1.02091337
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01253623
103TCF4_23295773_ChIP-Seq_U87_Human1.01088611
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.00926711
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99897475
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.99809609
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98871520
108CBP_20019798_ChIP-Seq_JUKART_Human0.98871520
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.98337353
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97586745
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97397400
112ZFX_18555785_Chip-Seq_ESCs_Mouse0.97228142
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97196351
114STAT1_17558387_ChIP-Seq_HELA_Human0.96288545
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95875144
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95302911
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94652557
118HNF4A_19822575_ChIP-Seq_HepG2_Human0.93412789
119SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92574306
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.91953527
121RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90413352
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89902368
123* GABP_17652178_ChIP-ChIP_JURKAT_Human0.89900396
124HNFA_21074721_ChIP-Seq_CACO-2_Human0.89374457
125* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88772453
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88705345
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87949797
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.87172071
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87133246
130AR_21909140_ChIP-Seq_LNCAP_Human0.86804272
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85775117
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84982825
133P300_18555785_Chip-Seq_ESCs_Mouse0.84482679
134PHF8_20622853_ChIP-Seq_HELA_Human0.84045467
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.82568657
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82544106
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82308855
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81857832
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81039371
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80312591
141CBP_21632823_ChIP-Seq_H3396_Human0.80277448
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80140752
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79533657
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.79384171
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79076876
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78591335
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.77727783
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.77360093
149GATA6_21074721_ChIP-Seq_CACO-2_Human0.76660169
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.76595446
151NFYA_21822215_ChIP-Seq_K562_Human0.75692178
152KLF4_18555785_Chip-Seq_ESCs_Mouse0.75506241
153AR_20517297_ChIP-Seq_VCAP_Human0.75049101
154NANOG_20526341_ChIP-Seq_ESCs_Human0.73779415
155EOMES_21245162_ChIP-Seq_HESCs_Human0.73463801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.79194433
2MP0005360_urolithiasis6.24112203
3MP0005365_abnormal_bile_salt4.93464782
4MP0005085_abnormal_gallbladder_physiolo4.70625206
5MP0003806_abnormal_nucleotide_metabolis4.15091656
6MP0008875_abnormal_xenobiotic_pharmacok4.14176040
7MP0005451_abnormal_body_composition3.72441995
8MP0003195_calcinosis3.07413641
9MP0002009_preneoplasia2.99612155
10MP0000749_muscle_degeneration2.87822656
11MP0009840_abnormal_foam_cell2.80678593
12MP0005332_abnormal_amino_acid2.76170113
13MP0003252_abnormal_bile_duct2.64585488
14MP0004084_abnormal_cardiac_muscle2.63689804
15MP0002638_abnormal_pupillary_reflex2.42873870
16MP0010329_abnormal_lipoprotein_level2.37137526
17MP0008789_abnormal_olfactory_epithelium2.35961598
18MP0001666_abnormal_nutrient_absorption2.35274204
19MP0004215_abnormal_myocardial_fiber2.23864867
20MP0003718_maternal_effect2.19829593
21MP0005083_abnormal_biliary_tract2.12149227
22MP0005408_hypopigmentation2.08385473
23MP0006054_spinal_hemorrhage1.98977211
24MP0002138_abnormal_hepatobiliary_system1.91556330
25MP0002118_abnormal_lipid_homeostasis1.86870200
26MP0003690_abnormal_glial_cell1.85256100
27MP0004272_abnormal_basement_membrane1.80234484
28MP0003828_pulmonary_edema1.74702615
29MP0000609_abnormal_liver_physiology1.72302144
30MP0005248_abnormal_Harderian_gland1.70439351
31MP0003186_abnormal_redox_activity1.69778595
32MP0005187_abnormal_penis_morphology1.69725010
33MP0010234_abnormal_vibrissa_follicle1.67739667
34MP0005584_abnormal_enzyme/coenzyme_acti1.66592748
35MP0009697_abnormal_copulation1.65239764
36MP0003191_abnormal_cellular_cholesterol1.64453543
37MP0003868_abnormal_feces_composition1.62257793
38MP0004147_increased_porphyrin_level1.61814691
39MP0005499_abnormal_olfactory_system1.61759073
40MP0005394_taste/olfaction_phenotype1.61759073
41MP0010352_gastrointestinal_tract_polyps1.59752561
42MP0000569_abnormal_digit_pigmentation1.58743274
43MP0000372_irregular_coat_pigmentation1.58405886
44MP0000920_abnormal_myelination1.57665480
45MP0005367_renal/urinary_system_phenotyp1.57648859
46MP0000516_abnormal_urinary_system1.57648859
47MP0004019_abnormal_vitamin_homeostasis1.56198953
48MP0001984_abnormal_olfaction1.55800805
49MP0000751_myopathy1.49684155
50MP0009780_abnormal_chondrocyte_physiolo1.49683644
51MP0004883_abnormal_blood_vessel1.46714032
52MP0003329_amyloid_beta_deposits1.45696947
53MP0001764_abnormal_homeostasis1.43922596
54MP0009643_abnormal_urine_homeostasis1.42777840
55MP0006072_abnormal_retinal_apoptosis1.42470521
56MP0000647_abnormal_sebaceous_gland1.42190177
57MP0005319_abnormal_enzyme/_coenzyme1.40792614
58MP0005253_abnormal_eye_physiology1.36071288
59MP0002909_abnormal_adrenal_gland1.35784423
60MP0004043_abnormal_pH_regulation1.33262254
61MP0000604_amyloidosis1.30687235
62MP0003656_abnormal_erythrocyte_physiolo1.25171243
63MP0006036_abnormal_mitochondrial_physio1.24490295
64MP0000566_synostosis1.23795155
65MP0003950_abnormal_plasma_membrane1.22349932
66MP0002972_abnormal_cardiac_muscle1.20829492
67MP0005395_other_phenotype1.20591150
68MP0005670_abnormal_white_adipose1.20527654
69MP0010386_abnormal_urinary_bladder1.19488385
70MP0001879_abnormal_lymphatic_vessel1.18793260
71MP0005084_abnormal_gallbladder_morpholo1.17958112
72MP0005330_cardiomyopathy1.17475798
73MP0008058_abnormal_DNA_repair1.17234497
74MP0005645_abnormal_hypothalamus_physiol1.16843926
75MP0002160_abnormal_reproductive_system1.15634649
76MP0004782_abnormal_surfactant_physiolog1.14677050
77MP0003011_delayed_dark_adaptation1.13639567
78MP0005647_abnormal_sex_gland1.13278446
79MP0002876_abnormal_thyroid_physiology1.11620896
80MP0004145_abnormal_muscle_electrophysio1.11555239
81MP0003646_muscle_fatigue1.11350664
82MP0010368_abnormal_lymphatic_system1.07621641
83MP0002166_altered_tumor_susceptibility1.07222246
84MP0000427_abnormal_hair_cycle1.05498125
85MP0000639_abnormal_adrenal_gland1.05470265
86MP0005636_abnormal_mineral_homeostasis1.05015635
87MP0004484_altered_response_of1.04013034
88MP0005646_abnormal_pituitary_gland1.03408025
89MP0005058_abnormal_lysosome_morphology1.03184630
90MP0004381_abnormal_hair_follicle1.01283912
91MP0002163_abnormal_gland_morphology1.00678884
92MP0009764_decreased_sensitivity_to1.00018537
93MP0006276_abnormal_autonomic_nervous0.99970980
94MP0001529_abnormal_vocalization0.98335961
95MP0001905_abnormal_dopamine_level0.95750218
96MP0002090_abnormal_vision0.93226578
97MP0005164_abnormal_response_to0.93163000
98MP0002233_abnormal_nose_morphology0.92407977
99MP0002837_dystrophic_cardiac_calcinosis0.92263739
100MP0009763_increased_sensitivity_to0.92124401
101MP0008469_abnormal_protein_level0.90647241
102MP0003786_premature_aging0.89297743
103MP0002269_muscular_atrophy0.88959000
104MP0002751_abnormal_autonomic_nervous0.87930607
105MP0002971_abnormal_brown_adipose0.86800514
106MP0005385_cardiovascular_system_phenoty0.85114657
107MP0001544_abnormal_cardiovascular_syste0.85114657
108MP0008260_abnormal_autophagy0.84841813
109MP0009765_abnormal_xenobiotic_induced0.84118259
110MP0005389_reproductive_system_phenotype0.83831771
111MP0000015_abnormal_ear_pigmentation0.81462119
112MP0000598_abnormal_liver_morphology0.79377249
113MP0000462_abnormal_digestive_system0.79342705
114MP0002234_abnormal_pharynx_morphology0.78870333
115MP0000750_abnormal_muscle_regeneration0.77979449
116MP0008775_abnormal_heart_ventricle0.77908925
117MP0002006_tumorigenesis0.77500137
118MP0003183_abnormal_peptide_metabolism0.77352875
119MP0000230_abnormal_systemic_arterial0.76195518
120MP0000343_altered_response_to0.76157461
121MP0003699_abnormal_female_reproductive0.75983156
122MP0005379_endocrine/exocrine_gland_phen0.74917544
123MP0005620_abnormal_muscle_contractility0.74521915
124MP0000383_abnormal_hair_follicle0.72790255
125MP0001929_abnormal_gametogenesis0.72043051
126MP0000013_abnormal_adipose_tissue0.71874414
127MP0005310_abnormal_salivary_gland0.71604020
128MP0005376_homeostasis/metabolism_phenot0.70819433
129MP0004185_abnormal_adipocyte_glucose0.69791346
130MP0002127_abnormal_cardiovascular_syste0.69293193
131MP0001661_extended_life_span0.68887491
132MP0006138_congestive_heart_failure0.68795810
133MP0000465_gastrointestinal_hemorrhage0.68199099
134MP0009642_abnormal_blood_homeostasis0.68082588
135MP0002102_abnormal_ear_morphology0.67674235
136MP0002106_abnormal_muscle_physiology0.67355724
137MP0008877_abnormal_DNA_methylation0.66010451
138MP0005623_abnormal_meninges_morphology0.65964224
139MP0002095_abnormal_skin_pigmentation0.65259209
140MP0003941_abnormal_skin_development0.64998853
141MP0006035_abnormal_mitochondrial_morpho0.64472688
142MP0005666_abnormal_adipose_tissue0.64397818
143MP0002332_abnormal_exercise_endurance0.63892950
144MP0001346_abnormal_lacrimal_gland0.63874564
145MP0004036_abnormal_muscle_relaxation0.63596556
146MP0003890_abnormal_embryonic-extraembry0.62704684
147MP0005266_abnormal_metabolism0.62521544
148MP0002078_abnormal_glucose_homeostasis0.62518532
149MP0009384_cardiac_valve_regurgitation0.61891485
150MP0005535_abnormal_body_temperature0.61508376
151MP0002295_abnormal_pulmonary_circulatio0.60515828
152MP0003724_increased_susceptibility_to0.60229986
153MP0010678_abnormal_skin_adnexa0.59312844
154MP0001119_abnormal_female_reproductive0.58876349
155MP0005220_abnormal_exocrine_pancreas0.57788000
156MP0005551_abnormal_eye_electrophysiolog0.56977243
157MP0005334_abnormal_fat_pad0.55115407
158MP0001756_abnormal_urination0.54729554
159MP0003632_abnormal_nervous_system0.53050436
160MP0001542_abnormal_bone_strength0.52825807
161MP0002136_abnormal_kidney_physiology0.48771087
162MP0000579_abnormal_nail_morphology0.47539411
163MP0002229_neurodegeneration0.44888155
164MP0004742_abnormal_vestibular_system0.43478977
165MP0001765_abnormal_ion_homeostasis0.40458770
166MP0001851_eye_inflammation0.40281076

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89828666
2Intrahepatic cholestasis (HP:0001406)5.89239879
3Calf muscle hypertrophy (HP:0008981)5.66931793
4Deep venous thrombosis (HP:0002625)5.13255953
5Exercise-induced muscle cramps (HP:0003710)4.88460755
6Muscle hypertrophy of the lower extremities (HP:0008968)4.78020041
7Prolonged partial thromboplastin time (HP:0003645)4.58397041
8Xanthomatosis (HP:0000991)4.41199766
9Abnormality of the left ventricular outflow tract (HP:0011103)4.29664643
10Subaortic stenosis (HP:0001682)4.29664643
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94568971
12Abnormality of aspartate family amino acid metabolism (HP:0010899)3.83791917
13Hyperlipoproteinemia (HP:0010980)3.81839547
14Abnormality of methionine metabolism (HP:0010901)3.70429717
15Fat malabsorption (HP:0002630)3.68691703
16Exercise-induced myalgia (HP:0003738)3.67890747
17Hypobetalipoproteinemia (HP:0003563)3.65156035
18Complement deficiency (HP:0004431)3.59871860
19Asymmetric septal hypertrophy (HP:0001670)3.56203752
20Hyperglycinuria (HP:0003108)3.54557578
21Hyperglycinemia (HP:0002154)3.53580041
22Abnormality of glycine metabolism (HP:0010895)3.51738458
23Abnormality of serine family amino acid metabolism (HP:0010894)3.51738458
24Hypoglycemic coma (HP:0001325)3.50536010
25Hyperammonemia (HP:0001987)3.46475079
26Ketosis (HP:0001946)3.36575603
27Abnormality of fatty-acid metabolism (HP:0004359)3.34293064
28Sudden death (HP:0001699)3.33208329
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31596254
30Medial flaring of the eyebrow (HP:0010747)3.30039897
31Abnormality of the calf musculature (HP:0001430)3.26503851
32Joint hemorrhage (HP:0005261)3.26236706
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.25525265
34Steatorrhea (HP:0002570)3.21758057
35Tubulointerstitial nephritis (HP:0001970)3.20937607
36Generalized aminoaciduria (HP:0002909)3.07862819
37Spastic paraparesis (HP:0002313)3.06055824
38Abnormality of the renal cortex (HP:0011035)2.99669030
39Abnormality of serum amino acid levels (HP:0003112)2.99078388
40Hypothermia (HP:0002045)2.93855588
41Abnormality of the intrinsic pathway (HP:0010989)2.93471743
42Abnormality of purine metabolism (HP:0004352)2.89760974
43Hypolipoproteinemia (HP:0010981)2.88361554
44Abnormality of the common coagulation pathway (HP:0010990)2.85598068
45Epidermoid cyst (HP:0200040)2.84350025
46Delayed CNS myelination (HP:0002188)2.81289273
47Lethargy (HP:0001254)2.81009697
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79285816
49Ketoacidosis (HP:0001993)2.77083228
50Proximal tubulopathy (HP:0000114)2.74996171
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74881895
52Dicarboxylic aciduria (HP:0003215)2.74881895
53Hypoglycemic seizures (HP:0002173)2.74514317
54Conjugated hyperbilirubinemia (HP:0002908)2.74224506
55Gowers sign (HP:0003391)2.73415886
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72209824
57Congenital primary aphakia (HP:0007707)2.71247469
58Glycosuria (HP:0003076)2.69858179
59Abnormality of urine glucose concentration (HP:0011016)2.69858179
60Hypoalphalipoproteinemia (HP:0003233)2.67574005
61Progressive macrocephaly (HP:0004481)2.65755607
62Acute necrotizing encephalopathy (HP:0006965)2.60493743
63Neurofibrillary tangles (HP:0002185)2.59701231
64Abnormality of glycolysis (HP:0004366)2.59086008
65Increased serum pyruvate (HP:0003542)2.59086008
66Hyperbilirubinemia (HP:0002904)2.55272355
67Supernumerary spleens (HP:0009799)2.54901514
68Gout (HP:0001997)2.54251332
69Cerebral edema (HP:0002181)2.50055090
70Metabolic acidosis (HP:0001942)2.47824960
71Abnormality of nucleobase metabolism (HP:0010932)2.45462252
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.45237827
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45237827
74Short tibia (HP:0005736)2.43849360
75Gait imbalance (HP:0002141)2.38752889
76Sensorimotor neuropathy (HP:0007141)2.37100520
77Palpebral edema (HP:0100540)2.36858495
78Abnormality of complement system (HP:0005339)2.36238000
79Renal cortical cysts (HP:0000803)2.35328486
80Gonadotropin excess (HP:0000837)2.35282472
81Sensory axonal neuropathy (HP:0003390)2.34422915
82Myotonia (HP:0002486)2.32297527
83Alkalosis (HP:0001948)2.30595060
84Metaphyseal dysplasia (HP:0100255)2.29892904
85Acute encephalopathy (HP:0006846)2.28024740
86Pheochromocytoma (HP:0002666)2.27993808
87Parakeratosis (HP:0001036)2.26092787
88Nausea (HP:0002018)2.24565872
89Thick nail (HP:0001805)2.24264953
90Hemiparesis (HP:0001269)2.23969059
91Increased purine levels (HP:0004368)2.23150668
92Hyperuricemia (HP:0002149)2.23150668
93Hepatic necrosis (HP:0002605)2.22973926
94Abnormal biliary tract morphology (HP:0012440)2.22871791
95Hypoplasia of the thymus (HP:0000778)2.21694297
96Nephrogenic diabetes insipidus (HP:0009806)2.21269462
97Papillary thyroid carcinoma (HP:0002895)2.19809062
98Median cleft lip (HP:0000161)2.18909661
99Left ventricular hypertrophy (HP:0001712)2.18233740
100Skin nodule (HP:0200036)2.16429052
101Abnormal gallbladder morphology (HP:0012437)2.14715185
102Poor suck (HP:0002033)2.13842316
103Adrenal hypoplasia (HP:0000835)2.13644602
104Conjunctival hamartoma (HP:0100780)2.12395399
105Tubulointerstitial abnormality (HP:0001969)2.12090116
106Neuroendocrine neoplasm (HP:0100634)2.12000121
107Brushfield spots (HP:0001088)2.10513252
108Spontaneous abortion (HP:0005268)2.10100822
109Abnormal mitochondria in muscle tissue (HP:0008316)2.09948325
110Paraparesis (HP:0002385)2.09703845
111Pancreatic fibrosis (HP:0100732)2.08621640
112Aplasia/Hypoplasia of the tibia (HP:0005772)2.08583254
113Hypercholesterolemia (HP:0003124)2.07496071
114Hamartoma of the eye (HP:0010568)2.06615489
115Axonal loss (HP:0003447)2.06374340
116Thyroid carcinoma (HP:0002890)2.05974795
117Genital tract atresia (HP:0001827)2.05761643
118Neck muscle weakness (HP:0000467)2.05590093
119Rhinitis (HP:0012384)2.05417339
120Methylmalonic acidemia (HP:0002912)2.05214394
121Irritability (HP:0000737)2.04948317
122Abnormal biliary tract physiology (HP:0012439)2.04096442
123Bile duct proliferation (HP:0001408)2.04096442
124Abolished electroretinogram (ERG) (HP:0000550)2.03026004
125Symptomatic seizures (HP:0011145)2.02992524
126Malnutrition (HP:0004395)2.02080922
127Hemorrhage of the eye (HP:0011885)2.00886155
128Vomiting (HP:0002013)2.00675890
129Orthostatic hypotension (HP:0001278)2.00374097
130Acanthocytosis (HP:0001927)1.99412819
131Hypokalemic alkalosis (HP:0001949)1.99001487
132Hematochezia (HP:0002573)1.98503845
1333-Methylglutaconic aciduria (HP:0003535)1.96967809
134Vascular calcification (HP:0004934)1.90121622
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89779418
136Renal Fanconi syndrome (HP:0001994)1.89429856
137Pancreatitis (HP:0001733)1.89107238
138Ventricular arrhythmia (HP:0004308)1.88391100
139Metabolic alkalosis (HP:0200114)1.88213380
140Abnormal gallbladder physiology (HP:0012438)1.87057473
141Cholecystitis (HP:0001082)1.87057473
142Cholelithiasis (HP:0001081)1.86507674
143Vascular tortuosity (HP:0004948)1.85730666
144Increased corneal curvature (HP:0100692)1.85611535
145Keratoconus (HP:0000563)1.85611535
146Opisthotonus (HP:0002179)1.85016345
147Prolonged QT interval (HP:0001657)1.84911142
148Methylmalonic aciduria (HP:0012120)1.83412124
149Systemic lupus erythematosus (HP:0002725)1.82425999
150Lipid accumulation in hepatocytes (HP:0006561)1.81540233
151Hyperinsulinemic hypoglycemia (HP:0000825)1.80637473
152Abnormality of vitamin metabolism (HP:0100508)1.79977006
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79820029
154Abnormal protein N-linked glycosylation (HP:0012347)1.79820029
155Abnormal protein glycosylation (HP:0012346)1.79820029
156Abnormal glycosylation (HP:0012345)1.79820029
157Prolonged neonatal jaundice (HP:0006579)1.78401923
158Elevated hepatic transaminases (HP:0002910)1.78061288
159Ependymoma (HP:0002888)1.78020085
160Erythroderma (HP:0001019)1.77209077
161Hypochromic microcytic anemia (HP:0004840)1.76821156
162Increased CSF lactate (HP:0002490)1.76574877
163Arterial tortuosity (HP:0005116)1.75881708
164Colon cancer (HP:0003003)1.75592221
165Abnormality of midbrain morphology (HP:0002418)1.75390764
166Molar tooth sign on MRI (HP:0002419)1.75390764
167Upper limb muscle weakness (HP:0003484)1.75085892
168Hepatocellular carcinoma (HP:0001402)1.75037737
169Vaginal atresia (HP:0000148)1.74916299
170Increased muscle lipid content (HP:0009058)1.74306918
171Postaxial foot polydactyly (HP:0001830)1.73771675
172Popliteal pterygium (HP:0009756)1.72278535
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.70344512
174Neoplasm of the peripheral nervous system (HP:0100007)1.70266247
175Increased CSF protein (HP:0002922)1.68215378
176Abnormality of vitamin B metabolism (HP:0004340)1.67986676
177Intestinal atresia (HP:0011100)1.67521249
178Mitochondrial inheritance (HP:0001427)1.66811044
179Reduced antithrombin III activity (HP:0001976)1.66569754
180Clitoromegaly (HP:0000057)1.66500890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.77661974
2MAP4K23.71658592
3NEK93.31334471
4ERBB43.11544648
5BCKDK3.08632366
6MUSK2.87662675
7STK38L2.83507028
8STK392.81619664
9MAP3K132.74821159
10OXSR12.72932572
11CCNB12.67777860
12BLK2.62481662
13EIF2AK32.48529639
14IRAK32.32535761
15IRAK42.14774598
16PLK22.13663347
17AKT32.06990462
18MOS2.04322787
19LATS11.98959457
20IRAK21.92301361
21MAP3K41.77239237
22EPHB11.75927426
23INSRR1.73297178
24TAOK11.72470167
25PLK41.70918408
26MAP3K61.62487626
27IRAK11.60797576
28SCYL21.53214944
29NEK61.48854551
30FER1.48221239
31MAPKAPK51.46247040
32BCR1.46140972
33PBK1.43325032
34PIK3CA1.43279067
35WNK41.42112843
36ARAF1.40985639
37GRK71.39902080
38PINK11.36899443
39BMPR21.34952197
40DYRK21.30875546
41BRAF1.28295387
42ACVR1B1.25755463
43ERBB31.22110203
44PRKAA21.18929363
45PKN11.18505357
46STK101.17814878
47MAPK111.17450032
48PRKCE1.14502690
49BMPR1B1.13760398
50SGK2231.13137531
51SGK4941.13137531
52LIMK11.08599908
53MAP3K21.06262988
54MAP3K31.05324536
55PDK21.02501258
56DMPK1.02370396
57MYLK1.01883977
58NEK11.01517731
59CSNK1G11.01000545
60CDK191.00070720
61MET0.99883540
62CDK90.99545249
63PNCK0.98980890
64CSNK1G30.96037107
65JAK20.94349067
66TRIM280.94288732
67FGFR40.90891349
68BRSK20.90704269
69CASK0.89441764
70TGFBR20.86345963
71ABL20.86241673
72NUAK10.85698082
73TTK0.83460345
74PLK30.83417019
75CAMK2G0.83181565
76PIM20.81907136
77CSNK1A1L0.80271803
78VRK10.79270588
79PIK3CG0.79242295
80FGFR20.79063755
81LMTK20.77384066
82KSR20.77348075
83ERN10.77308090
84EPHB20.76828671
85SIK10.75169314
86MELK0.74405730
87CDK30.73863621
88DYRK30.71151300
89CDK80.69262437
90WEE10.69134426
91STK30.68868936
92TESK20.68392214
93MAP2K70.68080025
94MAP3K70.66578697
95SRPK10.66572634
96MAP3K140.66542658
97TYK20.66503227
98MAPK150.65464279
99RAF10.65336336
100GRK10.65314632
101STK40.65105845
102FLT30.63530088
103IKBKE0.62306508
104CSNK1G20.61309093
105ZAK0.59055826
106PAK60.56769901
107PRKAA10.56570241
108PRKCQ0.55410796
109NLK0.53782035
110FRK0.53332926
111TNIK0.53321658
112OBSCN0.52674975
113PRKCI0.52550193
114PLK10.52103369
115PRKACB0.50770378
116BUB10.49932124
117MAP3K120.49665338
118FGFR10.49389141
119CAMK1D0.49296112
120CAMK2A0.48549494
121ADRBK20.47322597
122CAMK2D0.46738422
123MST40.45800175
124EIF2AK20.44861570
125PDPK10.44085773
126HIPK20.43718640
127MAPK70.42394213
128JAK10.41385632
129LATS20.40998379
130KIT0.39205199
131MAPK40.38832459
132TIE10.37134166
133NME10.36858516
134PRKG10.36768922
135EGFR0.36533419
136PRKCG0.36342361
137RPS6KA50.35887285
138EPHA30.35816487
139WNK30.34809950
140CSNK1D0.34512777
141STK160.34241161
142PIM10.32658511
143CHEK20.32044124
144PTK2B0.31509679
145ABL10.31342789
146EIF2AK10.31180049
147SGK20.30974432
148TESK10.29096773
149KSR10.28529988
150YES10.27341298

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.54077951
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75199066
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74741542
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69798097
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66704866
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63100635
7Fatty acid elongation_Homo sapiens_hsa000622.59530585
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54362073
9Propanoate metabolism_Homo sapiens_hsa006402.43518250
10Nitrogen metabolism_Homo sapiens_hsa009102.36919106
11Tryptophan metabolism_Homo sapiens_hsa003802.34345522
12Peroxisome_Homo sapiens_hsa041462.31344086
13Butanoate metabolism_Homo sapiens_hsa006502.30186893
14Fatty acid degradation_Homo sapiens_hsa000712.24656212
15Steroid biosynthesis_Homo sapiens_hsa001002.17634161
16Arginine biosynthesis_Homo sapiens_hsa002202.15914917
17Vitamin B6 metabolism_Homo sapiens_hsa007502.15496540
18Sulfur metabolism_Homo sapiens_hsa009202.12961075
19Folate biosynthesis_Homo sapiens_hsa007902.12783362
20Histidine metabolism_Homo sapiens_hsa003402.06756351
21Complement and coagulation cascades_Homo sapiens_hsa046101.99906469
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99221071
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91153335
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88358474
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80675868
26Fatty acid metabolism_Homo sapiens_hsa012121.79321096
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.76924528
28beta-Alanine metabolism_Homo sapiens_hsa004101.65281089
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63400322
30Chemical carcinogenesis_Homo sapiens_hsa052041.63392574
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56486758
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.51039503
33Retinol metabolism_Homo sapiens_hsa008301.50039614
34PPAR signaling pathway_Homo sapiens_hsa033201.49144580
35Pyruvate metabolism_Homo sapiens_hsa006201.48769973
36Caffeine metabolism_Homo sapiens_hsa002321.44546262
37Staphylococcus aureus infection_Homo sapiens_hsa051501.44138533
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41519017
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40473071
40Arginine and proline metabolism_Homo sapiens_hsa003301.38400950
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29854435
42Linoleic acid metabolism_Homo sapiens_hsa005911.29464354
43Mismatch repair_Homo sapiens_hsa034301.29250332
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29165897
45Proteasome_Homo sapiens_hsa030501.24575317
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.23603666
47Ether lipid metabolism_Homo sapiens_hsa005651.22676449
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.22591455
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21607276
50Vitamin digestion and absorption_Homo sapiens_hsa049771.19011182
51Tyrosine metabolism_Homo sapiens_hsa003501.16649979
52Protein export_Homo sapiens_hsa030601.15682654
53Sulfur relay system_Homo sapiens_hsa041221.13820988
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11826686
55Phenylalanine metabolism_Homo sapiens_hsa003601.07116289
56Glutathione metabolism_Homo sapiens_hsa004801.05716217
57ABC transporters_Homo sapiens_hsa020101.03007033
58Selenocompound metabolism_Homo sapiens_hsa004500.96301936
59Starch and sucrose metabolism_Homo sapiens_hsa005000.90394639
60Fat digestion and absorption_Homo sapiens_hsa049750.89797140
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86774507
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86446115
63Bile secretion_Homo sapiens_hsa049760.85505376
64Arachidonic acid metabolism_Homo sapiens_hsa005900.85259480
65Carbon metabolism_Homo sapiens_hsa012000.85124600
66Biosynthesis of amino acids_Homo sapiens_hsa012300.83010315
67Ovarian steroidogenesis_Homo sapiens_hsa049130.78979725
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.78663781
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77085975
70Metabolic pathways_Homo sapiens_hsa011000.72966236
71p53 signaling pathway_Homo sapiens_hsa041150.71283577
72Collecting duct acid secretion_Homo sapiens_hsa049660.69148403
73Fanconi anemia pathway_Homo sapiens_hsa034600.68724674
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65373279
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63759442
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63310738
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61860369
78Glycerolipid metabolism_Homo sapiens_hsa005610.58500759
79Nucleotide excision repair_Homo sapiens_hsa034200.58433158
80Cardiac muscle contraction_Homo sapiens_hsa042600.56091392
81Sphingolipid metabolism_Homo sapiens_hsa006000.54622689
82Pentose phosphate pathway_Homo sapiens_hsa000300.54210906
83Oxidative phosphorylation_Homo sapiens_hsa001900.54012488
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.53654797
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49582227
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.49345345
87RNA polymerase_Homo sapiens_hsa030200.47850643
88Basal transcription factors_Homo sapiens_hsa030220.47405518
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47059356
90Legionellosis_Homo sapiens_hsa051340.45489580
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42434505
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41968534
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40184488
94Circadian rhythm_Homo sapiens_hsa047100.39498236
95Other glycan degradation_Homo sapiens_hsa005110.36699374
96RNA degradation_Homo sapiens_hsa030180.36672169
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36043853
98Homologous recombination_Homo sapiens_hsa034400.35391617
99Lysine degradation_Homo sapiens_hsa003100.33489487
100Mineral absorption_Homo sapiens_hsa049780.31762262
101Oocyte meiosis_Homo sapiens_hsa041140.29659762
102Alcoholism_Homo sapiens_hsa050340.29269514
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28795562
104Fatty acid biosynthesis_Homo sapiens_hsa000610.25899170
105African trypanosomiasis_Homo sapiens_hsa051430.25237825
106Parkinsons disease_Homo sapiens_hsa050120.23593522
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23061424
108Regulation of autophagy_Homo sapiens_hsa041400.20331395
109Lysosome_Homo sapiens_hsa041420.20095175
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13311897
111Alzheimers disease_Homo sapiens_hsa050100.11644681
112Purine metabolism_Homo sapiens_hsa002300.08473308
113Huntingtons disease_Homo sapiens_hsa050160.04504217
114Pyrimidine metabolism_Homo sapiens_hsa002400.03751055
115Prion diseases_Homo sapiens_hsa050200.02125201
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.00772155
117SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0701110
118Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0638383
119One carbon pool by folate_Homo sapiens_hsa00670-0.0563568
120Non-homologous end-joining_Homo sapiens_hsa03450-0.0543548
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0537241
122TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0511873
123Insulin resistance_Homo sapiens_hsa04931-0.0502141

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