FBXO9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.80464473
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80464473
3L-phenylalanine metabolic process (GO:0006558)4.72196743
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.72196743
5aromatic amino acid family catabolic process (GO:0009074)4.04701477
6cysteine metabolic process (GO:0006534)4.01241945
7positive regulation of gamma-delta T cell activation (GO:0046645)4.00695471
8negative regulation of erythrocyte differentiation (GO:0045647)3.86622473
9positive regulation of granulocyte differentiation (GO:0030854)3.83410181
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82092275
11negative regulation of cell killing (GO:0031342)3.82092275
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75923807
13cellular ketone body metabolic process (GO:0046950)3.63609225
14lysine metabolic process (GO:0006553)3.63154234
15lysine catabolic process (GO:0006554)3.63154234
16bile acid biosynthetic process (GO:0006699)3.61821310
17kynurenine metabolic process (GO:0070189)3.61790572
18oxygen transport (GO:0015671)3.60513497
19iron ion import (GO:0097286)3.45701928
20indole-containing compound catabolic process (GO:0042436)3.45349714
21indolalkylamine catabolic process (GO:0046218)3.45349714
22tryptophan catabolic process (GO:0006569)3.45349714
23sulfur amino acid catabolic process (GO:0000098)3.42810643
24glutamate metabolic process (GO:0006536)3.39880259
25negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.37624697
26negative regulation of T-helper cell differentiation (GO:0045623)3.37624697
27high-density lipoprotein particle remodeling (GO:0034375)3.36686481
28necroptotic process (GO:0070266)3.34377338
29neuronal action potential propagation (GO:0019227)3.34225286
30regulation of ARF protein signal transduction (GO:0032012)3.33586545
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30146156
32alpha-linolenic acid metabolic process (GO:0036109)3.29077144
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29039114
34gas transport (GO:0015669)3.28829468
35regulation of necroptotic process (GO:0060544)3.27000429
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23996409
37synaptic vesicle maturation (GO:0016188)3.23855811
38synaptic vesicle exocytosis (GO:0016079)3.22812237
39amino-acid betaine metabolic process (GO:0006577)3.20624789
40regulation of B cell receptor signaling pathway (GO:0050855)3.20484423
41tryptophan metabolic process (GO:0006568)3.20294595
42glutamate secretion (GO:0014047)3.19619867
43cellular response to ethanol (GO:0071361)3.18542324
44hemoglobin metabolic process (GO:0020027)3.15628420
45coenzyme catabolic process (GO:0009109)3.13304248
46glyoxylate metabolic process (GO:0046487)3.13159591
47ketone body metabolic process (GO:1902224)3.09932649
48regulation of gamma-delta T cell differentiation (GO:0045586)3.08810669
49cellular extravasation (GO:0045123)3.06090297
50positive regulation of Rap GTPase activity (GO:0032854)3.05497600
51short-chain fatty acid metabolic process (GO:0046459)3.05306812
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.04715508
53regulation of gamma-delta T cell activation (GO:0046643)3.04429390
54drug transmembrane transport (GO:0006855)3.04097714
55aromatic amino acid family metabolic process (GO:0009072)3.04066821
56cellular modified amino acid catabolic process (GO:0042219)3.03804245
57alpha-amino acid catabolic process (GO:1901606)3.03778318
58serine family amino acid catabolic process (GO:0009071)3.01264954
59regulation of platelet aggregation (GO:0090330)2.99376984
60regulation of fibrinolysis (GO:0051917)2.98771699
61bile acid metabolic process (GO:0008206)2.98262289
62regulation of protein activation cascade (GO:2000257)2.98189563
63response to methylmercury (GO:0051597)2.97852947
64urea cycle (GO:0000050)2.95553876
65urea metabolic process (GO:0019627)2.95553876
66detection of molecule of bacterial origin (GO:0032490)2.95332444
67succinate metabolic process (GO:0006105)2.95024887
68neurotransmitter secretion (GO:0007269)2.94787290
69protein carboxylation (GO:0018214)2.94769782
70peptidyl-glutamic acid carboxylation (GO:0017187)2.94769782
71cellular amino acid catabolic process (GO:0009063)2.93730629
722-oxoglutarate metabolic process (GO:0006103)2.93445029
73oxaloacetate metabolic process (GO:0006107)2.93079687
74dicarboxylic acid biosynthetic process (GO:0043650)2.92757705
75regulation of synaptic vesicle transport (GO:1902803)2.91507368
76regulation of synaptic vesicle exocytosis (GO:2000300)2.91290792
77neutrophil activation involved in immune response (GO:0002283)2.91029784
78reverse cholesterol transport (GO:0043691)2.91008295
79detection of other organism (GO:0098543)2.90327938
80aspartate family amino acid catabolic process (GO:0009068)2.88786838
81sodium ion export (GO:0071436)2.86680200
82negative regulation of fibrinolysis (GO:0051918)2.86480753
83regulation of triglyceride catabolic process (GO:0010896)2.86375774
84negative regulation of type 2 immune response (GO:0002829)2.86176739
85neuromuscular process controlling posture (GO:0050884)2.85190061
86tyrosine metabolic process (GO:0006570)2.85033186
87gamma-aminobutyric acid transport (GO:0015812)2.84950197
88monoubiquitinated protein deubiquitination (GO:0035520)2.84684791
89plasma lipoprotein particle remodeling (GO:0034369)2.84467148
90protein-lipid complex remodeling (GO:0034368)2.84467148
91macromolecular complex remodeling (GO:0034367)2.84467148
92regulation of granulocyte differentiation (GO:0030852)2.82278379
93protoporphyrinogen IX biosynthetic process (GO:0006782)2.80831459
94complement activation, alternative pathway (GO:0006957)2.80657684
95definitive hemopoiesis (GO:0060216)2.80653754
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80396265
97erythrocyte development (GO:0048821)2.80113061
98cholesterol catabolic process (GO:0006707)2.79794411
99sterol catabolic process (GO:0016127)2.79794411
100regulation of cholesterol esterification (GO:0010872)2.79444053
101protoporphyrinogen IX metabolic process (GO:0046501)2.79189212
102nitrogen cycle metabolic process (GO:0071941)2.78929149
103regulation of complement activation (GO:0030449)2.78563400
104cellular potassium ion homeostasis (GO:0030007)2.78463285
105regulation of beta-amyloid formation (GO:1902003)2.78309045
106negative regulation of T cell mediated immunity (GO:0002710)2.77520217
107negative regulation of lymphocyte mediated immunity (GO:0002707)2.77439746
108ethanol oxidation (GO:0006069)2.76977833
109detection of bacterium (GO:0016045)2.76755395
110detection of external biotic stimulus (GO:0098581)2.75961236
111cellular response to epinephrine stimulus (GO:0071872)2.75294410
112programmed necrotic cell death (GO:0097300)2.74528961
113NADH metabolic process (GO:0006734)2.74388257
114phospholipid efflux (GO:0033700)2.72895561
115blood coagulation, intrinsic pathway (GO:0007597)2.72581984
116iron coordination entity transport (GO:1901678)2.72353786
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72147805
118mannose metabolic process (GO:0006013)2.71880690
119positive regulation of fibroblast migration (GO:0010763)2.71721533
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70376645
121triglyceride homeostasis (GO:0070328)2.70147638
122acylglycerol homeostasis (GO:0055090)2.70147638
123locomotory exploration behavior (GO:0035641)2.68344392
124carnitine metabolic process (GO:0009437)2.66997096
125necrotic cell death (GO:0070265)2.66348285
126benzene-containing compound metabolic process (GO:0042537)2.65537284
127valine metabolic process (GO:0006573)2.64581404
128carboxylic acid catabolic process (GO:0046395)2.64529893
129organic acid catabolic process (GO:0016054)2.64529893
130B cell receptor signaling pathway (GO:0050853)2.64131795
131monocarboxylic acid catabolic process (GO:0072329)2.64037806
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62728524
133regulation of necrotic cell death (GO:0010939)2.60822536
134fatty acid catabolic process (GO:0009062)2.59845684
135peroxisome fission (GO:0016559)2.59129277
136Peyers patch development (GO:0048541)2.57237112
137mucosal-associated lymphoid tissue development (GO:0048537)2.57237112
138regulation of leukocyte degranulation (GO:0043300)2.56493989
139dicarboxylic acid catabolic process (GO:0043649)2.54303178
140regulation of regulated secretory pathway (GO:1903305)2.54068774
141homocysteine metabolic process (GO:0050667)2.53866217
142acetyl-CoA metabolic process (GO:0006084)2.53782529
143regulation of mast cell degranulation (GO:0043304)2.53121963
144drug catabolic process (GO:0042737)2.53017554
145fatty acid oxidation (GO:0019395)2.52919084
146heme transport (GO:0015886)2.52914549
147activation of protein kinase A activity (GO:0034199)2.51836330
148fatty acid beta-oxidation (GO:0006635)2.50947333
149myeloid cell development (GO:0061515)2.50789863
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50787027
151low-density lipoprotein particle remodeling (GO:0034374)2.50268000
152lipid oxidation (GO:0034440)2.49714623
153regulation of mast cell activation involved in immune response (GO:0033006)2.48783144
154regulation of Rap GTPase activity (GO:0032317)2.48354015
155imidazole-containing compound metabolic process (GO:0052803)2.46153678
156negative regulation of necroptotic process (GO:0060546)2.46000050
157negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.45367597
158hepatocyte apoptotic process (GO:0097284)2.44266019
159regulation of memory T cell differentiation (GO:0043380)2.43960429
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43846262
161innate immune response in mucosa (GO:0002227)2.43646495
162positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43619197
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.43202658
164antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42978047
165response to interleukin-15 (GO:0070672)2.42194822
166phosphatidylinositol dephosphorylation (GO:0046856)2.41452968
167positive regulation of mast cell activation (GO:0033005)2.39087855
168negative regulation of leukocyte mediated immunity (GO:0002704)2.37284330
169defense response to fungus (GO:0050832)2.37105658
170regulation of amyloid precursor protein catabolic process (GO:1902991)2.37011652
171neutrophil mediated immunity (GO:0002446)2.35921537
172activated T cell proliferation (GO:0050798)2.34751559
173leukocyte aggregation (GO:0070486)2.34376702
174neutrophil activation (GO:0042119)2.34205091
175leukocyte migration involved in inflammatory response (GO:0002523)2.32570086
176phospholipid dephosphorylation (GO:0046839)2.30565860
177hypotonic response (GO:0006971)2.27592624
178phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27454116
179negative regulation of adaptive immune response (GO:0002820)2.27301480
180porphyrin-containing compound biosynthetic process (GO:0006779)2.27290655
181response to peptidoglycan (GO:0032494)2.27195221
182import into cell (GO:0098657)2.27092351
183antigen processing and presentation of endogenous antigen (GO:0019883)2.26614168
184detection of biotic stimulus (GO:0009595)2.25516322
185negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.22035879
186response to epinephrine (GO:0071871)2.21698232
187antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18294672
188megakaryocyte development (GO:0035855)2.17475663
189modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.17222708
190positive regulation by organism of defense response of other organism involved in symbiotic interact2.17222708
191modulation by symbiont of host immune response (GO:0052553)2.17222708
192positive regulation by symbiont of host defense response (GO:0052509)2.17222708
193modulation by symbiont of host defense response (GO:0052031)2.17222708
194modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.17222708
195regulation of inositol phosphate biosynthetic process (GO:0010919)2.16371030
196negative regulation of complement activation (GO:0045916)2.15682598
197cerebellar Purkinje cell differentiation (GO:0021702)2.15520871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.56915078
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.42733508
3EZH2_22144423_ChIP-Seq_EOC_Human3.71425648
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54891604
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.26939287
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.24886360
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23209264
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18310165
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.17330564
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.03004368
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.84936732
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.50593370
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49779613
14GATA1_22025678_ChIP-Seq_K562_Human2.46325971
15RUNX_20019798_ChIP-Seq_JUKART_Human2.41336251
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35501212
17REST_21632747_ChIP-Seq_MESCs_Mouse2.22776927
18VDR_21846776_ChIP-Seq_THP-1_Human2.20673628
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19696696
20* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10142832
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07875491
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07755534
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06004249
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05355110
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02020749
26GBX2_23144817_ChIP-Seq_PC3_Human2.01618359
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.01182069
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95016460
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93235167
30VDR_24763502_ChIP-Seq_THP-1_Human1.91054766
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88322008
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84754072
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80611723
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78891112
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78871451
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.78275150
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77890908
38TCF7_22412390_ChIP-Seq_EML_Mouse1.76969270
39SPI1_23127762_ChIP-Seq_K562_Human1.76394494
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73826905
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73311455
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73004439
43GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71179430
44TAF15_26573619_Chip-Seq_HEK293_Human1.70784804
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.67404295
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65984900
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65421056
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65086797
49KDM2B_26808549_Chip-Seq_DND41_Human1.58348244
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56737741
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56737741
52* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56349505
53MYC_22102868_ChIP-Seq_BL_Human1.55285762
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54522073
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54195930
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53616206
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53065943
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52277589
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.52150041
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51429906
61* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49644100
62* RUNX1_22412390_ChIP-Seq_EML_Mouse1.49161175
63ZNF263_19887448_ChIP-Seq_K562_Human1.47842445
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47346299
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.46667328
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42947290
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.41731662
68MYB_26560356_Chip-Seq_TH2_Human1.41484676
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40870953
70DROSHA_22980978_ChIP-Seq_HELA_Human1.40689151
71* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38351802
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.37233304
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36124809
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34703452
75* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34691667
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.28768829
77* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27772328
78VDR_24787735_ChIP-Seq_THP-1_Human1.27124764
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26012942
80UTX_26944678_Chip-Seq_JUKART_Human1.25044617
81MAF_26560356_Chip-Seq_TH1_Human1.24550938
82GATA1_19941826_ChIP-Seq_K562_Human1.23714356
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22496385
84HTT_18923047_ChIP-ChIP_STHdh_Human1.22492236
85MAF_26560356_Chip-Seq_TH2_Human1.21192934
86GATA3_27048872_Chip-Seq_THYMUS_Human1.20820101
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20788778
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.18152357
89MYB_26560356_Chip-Seq_TH1_Human1.17370257
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16748069
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15785869
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15774536
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13932119
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13690013
95AR_21572438_ChIP-Seq_LNCaP_Human1.13272181
96* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11791851
97SPI1_23547873_ChIP-Seq_NB4_Human1.10275445
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09668010
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.09120090
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07512005
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.07127653
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06791747
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05049586
104KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03393998
105ZNF274_21170338_ChIP-Seq_K562_Hela1.02974163
106PU_27001747_Chip-Seq_BMDM_Mouse1.02671296
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02636778
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99059411
109GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99032936
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97494835
111* SMAD4_21799915_ChIP-Seq_A2780_Human0.97178453
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96921334
113CTCF_27219007_Chip-Seq_Bcells_Human0.96633190
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96118207
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95976713
116BCAT_22108803_ChIP-Seq_LS180_Human0.95005989
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94678538
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93590443
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.91820379
120TP53_16413492_ChIP-PET_HCT116_Human0.91655898
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.89841074
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89325773
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89055301
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88459706
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88155469
126AR_25329375_ChIP-Seq_VCAP_Human0.88013159
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86522731
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.86401050
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85272078
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85091742
131CREB1_26743006_Chip-Seq_LNCaP_Human0.85087733
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84992946
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.84962968
134SCL_19346495_ChIP-Seq_HPC-7_Human0.84694470
135IGF1R_20145208_ChIP-Seq_DFB_Human0.84358509
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84022480
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82505503
138GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.82265446
139NCOR1_26117541_ChIP-Seq_K562_Human0.82074045
140GATA2_19941826_ChIP-Seq_K562_Human0.82058691
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82047088
142* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81528916
143LXR_22292898_ChIP-Seq_THP-1_Human0.81352447
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81225954
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80367013
146SMC4_20622854_ChIP-Seq_HELA_Human0.79456452
147KLF4_19829295_ChIP-Seq_ESCs_Human0.78539298
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.76021336
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75093242
150P300_19829295_ChIP-Seq_ESCs_Human0.74981083
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74570405
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73641435
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73088920
154CBP_20019798_ChIP-Seq_JUKART_Human0.72882918
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72882918
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.71913541
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69771217
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.69588396
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69458181
160KDM2B_26808549_Chip-Seq_K562_Human0.69112590
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68806768
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.68504552
163SOX2_19829295_ChIP-Seq_ESCs_Human0.67654584
164NANOG_19829295_ChIP-Seq_ESCs_Human0.67654584
165TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67525181
166TAF2_19829295_ChIP-Seq_ESCs_Human0.66501534
167* P53_21459846_ChIP-Seq_SAOS-2_Human0.66278406
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.66051043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.04909241
2MP0005360_urolithiasis4.07755573
3MP0005085_abnormal_gallbladder_physiolo3.93665650
4MP0005365_abnormal_bile_salt3.91220445
5MP0008875_abnormal_xenobiotic_pharmacok3.43983666
6MP0004859_abnormal_synaptic_plasticity3.31106789
7MP0004147_increased_porphyrin_level2.85600850
8MP0005083_abnormal_biliary_tract2.77501973
9MP0003172_abnormal_lysosome_physiology2.69894180
10MP0003880_abnormal_central_pattern2.67971345
11MP0000569_abnormal_digit_pigmentation2.66755609
12MP0003656_abnormal_erythrocyte_physiolo2.64725993
13MP0001968_abnormal_touch/_nociception2.54926266
14MP0010329_abnormal_lipoprotein_level2.40149014
15MP0001835_abnormal_antigen_presentation2.35848419
16MP0003635_abnormal_synaptic_transmissio2.30215814
17MP0003436_decreased_susceptibility_to2.25443695
18MP0005464_abnormal_platelet_physiology2.10837244
19MP0003724_increased_susceptibility_to2.08730344
20MP0002735_abnormal_chemical_nociception2.07189636
21MP0002132_abnormal_respiratory_system2.03484252
22MP0002736_abnormal_nociception_after1.98422162
23MP0005451_abnormal_body_composition1.95273831
24MP0003806_abnormal_nucleotide_metabolis1.93936594
25MP0005332_abnormal_amino_acid1.93396611
26MP0003763_abnormal_thymus_physiology1.93204450
27MP0009745_abnormal_behavioral_response1.93096787
28MP0001666_abnormal_nutrient_absorption1.90744901
29MP0004270_analgesia1.89462108
30MP0003329_amyloid_beta_deposits1.87119891
31MP0003300_gastrointestinal_ulcer1.87036555
32MP0009046_muscle_twitch1.86810674
33MP0002064_seizures1.85032795
34MP0002166_altered_tumor_susceptibility1.78808808
35MP0003252_abnormal_bile_duct1.78658450
36MP0000015_abnormal_ear_pigmentation1.73176991
37MP0002909_abnormal_adrenal_gland1.69526828
38MP0002733_abnormal_thermal_nociception1.68674385
39MP0002272_abnormal_nervous_system1.67321392
40MP0002396_abnormal_hematopoietic_system1.67183920
41MP0003303_peritoneal_inflammation1.66523440
42MP0004185_abnormal_adipocyte_glucose1.66188896
43MP0002063_abnormal_learning/memory/cond1.64838857
44MP0009840_abnormal_foam_cell1.64694238
45MP0003045_fibrosis1.64603545
46MP0002734_abnormal_mechanical_nocicepti1.64500667
47MP0002837_dystrophic_cardiac_calcinosis1.63885920
48MP0002971_abnormal_brown_adipose1.62920646
49MP0006036_abnormal_mitochondrial_physio1.61877240
50MP0002822_catalepsy1.60397587
51MP0002118_abnormal_lipid_homeostasis1.59946811
52MP0003868_abnormal_feces_composition1.58623235
53MP0003195_calcinosis1.58616323
54MP0003183_abnormal_peptide_metabolism1.55522080
55MP0006276_abnormal_autonomic_nervous1.53869914
56MP0002419_abnormal_innate_immunity1.52434995
57MP0000685_abnormal_immune_system1.51677403
58MP0001984_abnormal_olfaction1.47208853
59MP0005535_abnormal_body_temperature1.46973769
60MP0005584_abnormal_enzyme/coenzyme_acti1.46382400
61MP0005075_abnormal_melanosome_morpholog1.44512520
62MP0001800_abnormal_humoral_immune1.44113413
63MP0005025_abnormal_response_to1.42851526
64MP0001501_abnormal_sleep_pattern1.42680424
65MP0001970_abnormal_pain_threshold1.41341405
66MP0001661_extended_life_span1.40207064
67MP0002572_abnormal_emotion/affect_behav1.39863909
68MP0001545_abnormal_hematopoietic_system1.39597886
69MP0005397_hematopoietic_system_phenotyp1.39597886
70MP0001348_abnormal_lacrimal_gland1.38330678
71MP0001851_eye_inflammation1.37291952
72MP0003690_abnormal_glial_cell1.37175385
73MP0004381_abnormal_hair_follicle1.35989688
74MP0002067_abnormal_sensory_capabilities1.35869625
75MP0002398_abnormal_bone_marrow1.35110829
76MP0001790_abnormal_immune_system1.35042293
77MP0005387_immune_system_phenotype1.35042293
78MP0005058_abnormal_lysosome_morphology1.33081888
79MP0005174_abnormal_tail_pigmentation1.28234022
80MP0001873_stomach_inflammation1.26564033
81MP0001764_abnormal_homeostasis1.26258668
82MP0003191_abnormal_cellular_cholesterol1.26189994
83MP0004142_abnormal_muscle_tone1.26117971
84MP0004130_abnormal_muscle_cell1.25673573
85MP0005636_abnormal_mineral_homeostasis1.25599576
86MP0009780_abnormal_chondrocyte_physiolo1.25488698
87MP0002420_abnormal_adaptive_immunity1.25271817
88MP0008260_abnormal_autophagy1.24858451
89MP0001486_abnormal_startle_reflex1.24454182
90MP0005646_abnormal_pituitary_gland1.24253403
91MP0008057_abnormal_DNA_replication1.23080689
92MP0000703_abnormal_thymus_morphology1.21984998
93MP0001819_abnormal_immune_cell1.21896965
94MP0002876_abnormal_thyroid_physiology1.21542026
95MP0003828_pulmonary_edema1.20479311
96MP0000604_amyloidosis1.20103957
97MP0002723_abnormal_immune_serum1.19842297
98MP0000609_abnormal_liver_physiology1.19479378
99MP0005000_abnormal_immune_tolerance1.18597813
100MP0006035_abnormal_mitochondrial_morpho1.18258871
101MP0005319_abnormal_enzyme/_coenzyme1.18241594
102MP0005666_abnormal_adipose_tissue1.17723282
103MP0001440_abnormal_grooming_behavior1.16653771
104MP0003866_abnormal_defecation1.15320948
105MP0004019_abnormal_vitamin_homeostasis1.14272048
106MP0009115_abnormal_fat_cell1.14097117
107MP0002009_preneoplasia1.14006420
108MP0003879_abnormal_hair_cell1.12546770
109MP0002078_abnormal_glucose_homeostasis1.11185639
110MP0008872_abnormal_physiological_respon1.10404866
111MP0002332_abnormal_exercise_endurance1.09728985
112MP0002722_abnormal_immune_system1.08871865
113MP0008569_lethality_at_weaning1.08563338
114MP0004808_abnormal_hematopoietic_stem1.08390674
115MP0005084_abnormal_gallbladder_morpholo1.06260809
116MP0005551_abnormal_eye_electrophysiolog1.05878748
117MP0009785_altered_susceptibility_to1.04990878
118MP0005375_adipose_tissue_phenotype1.04910824
119MP0000371_diluted_coat_color1.04807411
120MP0003633_abnormal_nervous_system1.04511746
121MP0000716_abnormal_immune_system1.04482926
122MP0001502_abnormal_circadian_rhythm1.04094300
123MP0008874_decreased_physiological_sensi1.03376543
124MP0000003_abnormal_adipose_tissue1.03275596
125MP0000013_abnormal_adipose_tissue1.03157483
126MP0004145_abnormal_muscle_electrophysio1.02578679
127MP0004924_abnormal_behavior1.00924097
128MP0005386_behavior/neurological_phenoty1.00924097
129MP0000689_abnormal_spleen_morphology1.00516539
130MP0001533_abnormal_skeleton_physiology0.99464156
131MP0005423_abnormal_somatic_nervous0.99224549
132MP0004043_abnormal_pH_regulation0.97701187
133MP0002877_abnormal_melanocyte_morpholog0.96325449
134MP0002006_tumorigenesis0.95591518
135MP0002452_abnormal_antigen_presenting0.95391981
136MP0002429_abnormal_blood_cell0.94138794
137MP0004215_abnormal_myocardial_fiber0.94074357
138MP0010155_abnormal_intestine_physiology0.93687179
139MP0004947_skin_inflammation0.92600094
140MP0002229_neurodegeneration0.92353861
141MP0000465_gastrointestinal_hemorrhage0.92094669
142MP0002405_respiratory_system_inflammati0.89081423
143MP0002557_abnormal_social/conspecific_i0.87719398
144MP0009643_abnormal_urine_homeostasis0.86830125
145MP0000681_abnormal_thyroid_gland0.86445774
146MP0001765_abnormal_ion_homeostasis0.84943260
147MP0005670_abnormal_white_adipose0.84720562
148MP0003787_abnormal_imprinting0.82698767
149MP0001905_abnormal_dopamine_level0.81640702
150MP0008961_abnormal_basal_metabolism0.81630062
151MP0002138_abnormal_hepatobiliary_system0.81105587
152MP0002066_abnormal_motor_capabilities/c0.79789728
153MP0001845_abnormal_inflammatory_respons0.79417193
154MP0002090_abnormal_vision0.79192632
155MP0002970_abnormal_white_adipose0.79176619
156MP0000230_abnormal_systemic_arterial0.77722723
157MP0001958_emphysema0.77693068
158MP0003631_nervous_system_phenotype0.77062587
159MP0002184_abnormal_innervation0.76987022
160MP0000955_abnormal_spinal_cord0.76704948
161MP0004811_abnormal_neuron_physiology0.75924994
162MP0000747_muscle_weakness0.75507048
163MP0002693_abnormal_pancreas_physiology0.74946424
164MP0001664_abnormal_digestion0.74081435
165MP0003953_abnormal_hormone_level0.73488033
166MP0002069_abnormal_eating/drinking_beha0.73228427
167MP0004036_abnormal_muscle_relaxation0.73122517
168MP0000751_myopathy0.73014312
169MP0005448_abnormal_energy_balance0.71800053
170MP0005334_abnormal_fat_pad0.71065747
171MP0009642_abnormal_blood_homeostasis0.70239369
172MP0003011_delayed_dark_adaptation0.69745326
173MP0001986_abnormal_taste_sensitivity0.68884503

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.21703121
2Hypochromic anemia (HP:0001931)4.14992580
3Deep venous thrombosis (HP:0002625)4.04513029
4Myokymia (HP:0002411)3.91595597
5Intrahepatic cholestasis (HP:0001406)3.90431238
6Prolonged partial thromboplastin time (HP:0003645)3.77021081
7Hyperlipoproteinemia (HP:0010980)3.74511845
8Xanthomatosis (HP:0000991)3.63683717
9Focal motor seizures (HP:0011153)3.62752906
10Prolonged bleeding time (HP:0003010)3.55636029
11Ketosis (HP:0001946)3.53103215
12Cholecystitis (HP:0001082)3.35904561
13Abnormal gallbladder physiology (HP:0012438)3.35904561
14Visual hallucinations (HP:0002367)3.32203426
15Hypobetalipoproteinemia (HP:0003563)3.27028993
16Myositis (HP:0100614)3.26186546
17Eczematoid dermatitis (HP:0000976)3.25648076
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.24841852
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24097370
20Hyperbilirubinemia (HP:0002904)3.23350804
21Gastrointestinal infarctions (HP:0005244)3.23022538
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.22319174
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.19033604
24Hyperammonemia (HP:0001987)3.16343416
25Ketoacidosis (HP:0001993)3.13745579
26Neonatal hypoglycemia (HP:0001998)3.07596268
27Microcytic anemia (HP:0001935)3.03734245
28Poikilocytosis (HP:0004447)3.02214650
29Gout (HP:0001997)3.01311899
30Gingival bleeding (HP:0000225)3.01073707
31Recurrent bacterial skin infections (HP:0005406)3.00805875
32Acanthocytosis (HP:0001927)2.99877529
33Optic neuritis (HP:0100653)2.95182748
34Retrobulbar optic neuritis (HP:0100654)2.95182748
35Abnormality of the fingertips (HP:0001211)2.94987566
36Orchitis (HP:0100796)2.94093074
37Cholelithiasis (HP:0001081)2.92554288
38Hyperglycinemia (HP:0002154)2.92024601
39Hypoglycemic coma (HP:0001325)2.89876756
40Recurrent abscess formation (HP:0002722)2.87902258
41Abnormal gallbladder morphology (HP:0012437)2.81518699
42Slow saccadic eye movements (HP:0000514)2.80870433
43Complement deficiency (HP:0004431)2.79412366
44Spontaneous hematomas (HP:0007420)2.75083398
45Papilledema (HP:0001085)2.72927577
46Focal seizures (HP:0007359)2.71521944
47Status epilepticus (HP:0002133)2.69438326
48Polycythemia (HP:0001901)2.66988579
49Epistaxis (HP:0000421)2.65646674
50Abnormality of the common coagulation pathway (HP:0010990)2.64811192
51Hyperglycinuria (HP:0003108)2.62100815
52Abnormality of the intrinsic pathway (HP:0010989)2.59980936
53Febrile seizures (HP:0002373)2.59882550
54Atonic seizures (HP:0010819)2.58983002
55Ocular albinism (HP:0001107)2.58368517
56Hypolipoproteinemia (HP:0010981)2.55330640
57Progressive cerebellar ataxia (HP:0002073)2.54818801
58Generalized tonic-clonic seizures (HP:0002069)2.54083417
59Absence seizures (HP:0002121)2.52369502
60Episodic fever (HP:0001954)2.50903841
61Metabolic acidosis (HP:0001942)2.50322049
62Abnormality of glycine metabolism (HP:0010895)2.47232907
63Abnormality of serine family amino acid metabolism (HP:0010894)2.47232907
64Reticulocytosis (HP:0001923)2.47184247
65Recurrent fungal infections (HP:0002841)2.44061016
66Hypoglycemic seizures (HP:0002173)2.41561497
67Conjugated hyperbilirubinemia (HP:0002908)2.40818117
68Autoimmune hemolytic anemia (HP:0001890)2.39947314
69Epileptic encephalopathy (HP:0200134)2.39452171
70Abnormality of T cell number (HP:0011839)2.38345010
71Hypoalphalipoproteinemia (HP:0003233)2.38188450
72Abnormality of fatty-acid metabolism (HP:0004359)2.37608588
73Cerebral edema (HP:0002181)2.37335079
74Delayed CNS myelination (HP:0002188)2.36957125
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35274831
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.35250691
77Recurrent skin infections (HP:0001581)2.35166524
78Anxiety (HP:0000739)2.34019168
79Recurrent gram-negative bacterial infections (HP:0005420)2.33123011
80Scanning speech (HP:0002168)2.31373986
81Stomatitis (HP:0010280)2.30730253
82Action tremor (HP:0002345)2.30355679
83Postural instability (HP:0002172)2.30219057
84Neonatal onset (HP:0003623)2.29700750
85Sensorimotor neuropathy (HP:0007141)2.25979421
86Fat malabsorption (HP:0002630)2.25094537
87Abnormality of iron homeostasis (HP:0011031)2.23408863
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21650739
89Hepatic necrosis (HP:0002605)2.21303334
90Gingivitis (HP:0000230)2.20754249
91Peritonitis (HP:0002586)2.20353988
92Dialeptic seizures (HP:0011146)2.19817684
93Joint hemorrhage (HP:0005261)2.19250131
94Acute encephalopathy (HP:0006846)2.18256070
95Keratoconjunctivitis sicca (HP:0001097)2.17271896
96Ventricular fibrillation (HP:0001663)2.16265396
97Abnormality of transition element cation homeostasis (HP:0011030)2.15693790
98Inflammation of the large intestine (HP:0002037)2.15554206
99Abnormal hemoglobin (HP:0011902)2.15060161
100Depression (HP:0000716)2.14860722
101Pheochromocytoma (HP:0002666)2.14808639
102Lethargy (HP:0001254)2.13994960
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13776422
104Hypochromic microcytic anemia (HP:0004840)2.12953696
105Urticaria (HP:0001025)2.12930213
106Exercise-induced myalgia (HP:0003738)2.12775034
107Abnormality of methionine metabolism (HP:0010901)2.11238430
108Granulocytopenia (HP:0001913)2.11018253
109T lymphocytopenia (HP:0005403)2.10318612
110Iris hypopigmentation (HP:0007730)2.10112741
111Abnormality of sulfur amino acid metabolism (HP:0004339)2.09716825
112Neuroendocrine neoplasm (HP:0100634)2.09319507
113Brushfield spots (HP:0001088)2.08429919
114Gastrointestinal inflammation (HP:0004386)2.07568885
115Colitis (HP:0002583)2.06701754
116Fatigue (HP:0012378)2.05378238
117Dysostosis multiplex (HP:0000943)2.05128129
118Craniofacial dystonia (HP:0012179)2.05111163
119Epidermoid cyst (HP:0200040)2.04338098
120Focal dystonia (HP:0004373)2.04244900
121Abnormality of T cell physiology (HP:0011840)2.03419305
122Hepatocellular necrosis (HP:0001404)2.03368437
123Ragged-red muscle fibers (HP:0003200)2.03268366
124Dicarboxylic aciduria (HP:0003215)2.02834632
125Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02834632
126Abnormality of the gallbladder (HP:0005264)2.02770941
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02484256
128Meningitis (HP:0001287)2.02368094
129Torticollis (HP:0000473)2.02291006
130Progressive inability to walk (HP:0002505)2.02270296
131Spontaneous abortion (HP:0005268)2.01997387
132Supranuclear gaze palsy (HP:0000605)2.01446573
133Dysmetric saccades (HP:0000641)2.00939475
134Acne (HP:0001061)2.00822329
135Myoglobinuria (HP:0002913)1.99582821
136Hyperventilation (HP:0002883)1.99131928
137Pustule (HP:0200039)1.99047817
138Abnormality of serum amino acid levels (HP:0003112)1.98044436
139Petechiae (HP:0000967)1.97167090
140Increased IgE level (HP:0003212)1.96040263
141Cerebral hemorrhage (HP:0001342)1.95826423
142Acute hepatic failure (HP:0006554)1.95161161
143Arterial thrombosis (HP:0004420)1.94832504
144Paralysis (HP:0003470)1.94007948
145Dysdiadochokinesis (HP:0002075)1.93956633
146Abnormality of purine metabolism (HP:0004352)1.93163176
147Lactic acidosis (HP:0003128)1.92981456
148Late onset (HP:0003584)1.92748212
149Hypercholesterolemia (HP:0003124)1.92692986
150Keratoconjunctivitis (HP:0001096)1.91574167
151Ankle clonus (HP:0011448)1.91011567
152Abnormality of T cells (HP:0002843)1.90851190
153Impaired social interactions (HP:0000735)1.90100480
154Abnormal social behavior (HP:0012433)1.90100480
155Increased muscle lipid content (HP:0009058)1.89659169
156Irritability (HP:0000737)1.89579833
157Recurrent cutaneous fungal infections (HP:0011370)1.89462872
158Chronic mucocutaneous candidiasis (HP:0002728)1.89462872
159Increased serum ferritin (HP:0003281)1.89382386
160Purpura (HP:0000979)1.88344248
161Vomiting (HP:0002013)1.88263837
162Vasculitis (HP:0002633)1.88196769
163Bradykinesia (HP:0002067)1.85268540
164Glucose intolerance (HP:0000833)1.84986930
165Generalized hyperpigmentation (HP:0007440)1.84875432
166Pulmonary embolism (HP:0002204)1.84842086
167Hyperinsulinemic hypoglycemia (HP:0000825)1.84143459
168Elevated erythrocyte sedimentation rate (HP:0003565)1.84039394
169Hyperthyroidism (HP:0000836)1.83004877
170Albinism (HP:0001022)1.82646143
171Obstructive lung disease (HP:0006536)1.79707670
172Chronic obstructive pulmonary disease (HP:0006510)1.79707670
173Abnormality of macrophages (HP:0004311)1.78974631
174Arthropathy (HP:0003040)1.78573841
175Obstructive sleep apnea (HP:0002870)1.77549215
176Recurrent viral infections (HP:0004429)1.77504940
177Rectal prolapse (HP:0002035)1.76287914
178Amyloidosis (HP:0011034)1.76058723
179Pulmonary infiltrates (HP:0002113)1.75008237
180Encephalitis (HP:0002383)1.74743804
181Bruising susceptibility (HP:0000978)1.74515698
182Osteomyelitis (HP:0002754)1.73613966
183Cellulitis (HP:0100658)1.72794738
184Abnormality of polysaccharide metabolism (HP:0011012)1.72100986
185Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72100986
186Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72100986
187Abnormality of saccadic eye movements (HP:0000570)1.71349095
188Toxemia of pregnancy (HP:0100603)1.70699648
189Autoimmune thrombocytopenia (HP:0001973)1.70592463
190Hypoplasia of the thymus (HP:0000778)1.70212263
191Testicular neoplasm (HP:0010788)1.68406475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.56837663
2BCKDK3.38541119
3PINK12.83489961
4MAP2K42.79900924
5ARAF2.73446419
6MAP3K92.68275050
7KSR22.65880926
8MAP3K122.63374145
9MAP3K42.49507357
10MAP2K72.44904051
11EPHA42.30362808
12RIPK42.24044429
13MINK12.18981749
14PRPF4B2.02986353
15AKT32.01438202
16DAPK21.99986555
17GRK51.90254002
18ICK1.80657031
19NTRK11.72646965
20MAP3K131.72043763
21PAK61.71844368
22BMPR21.68555775
23TYK21.65875436
24BLK1.62648175
25TNIK1.58406828
26INSRR1.53126762
27RAF11.53071682
28CDK191.52778282
29PHKG21.52535034
30PHKG11.52535034
31CAMKK21.51226518
32CAMKK11.48192438
33LMTK21.46003682
34MAP3K21.45936020
35CAMK1D1.31515644
36SYK1.30199150
37JAK11.29722714
38MAP3K31.29343880
39ZAP701.29335799
40CAMK1G1.25992232
41MAP3K11.25966179
42RET1.23699889
43SCYL21.22587468
44TAOK11.21817716
45PRKD31.18995071
46WNK11.18218310
47TNK21.17351161
48CDK51.15664527
49FES1.13963501
50DAPK11.13580283
51MAPKAPK51.11163194
52TRPM71.10782737
53FGFR31.06886874
54CDK121.06309617
55PRKCG1.05089844
56MAP4K11.04262138
57PKN21.03604669
58TAOK31.02925692
59STK380.99882477
60BTK0.99132224
61PIK3CA0.98138982
62STK110.97681131
63PDK10.95295414
64MARK10.92855698
65MARK20.92297143
66MAP3K110.91244037
67IRAK40.90280020
68MAP2K10.88524359
69MUSK0.87706742
70CAMK10.87691791
71PDPK10.86889843
72JAK30.86310848
73SIK20.85799574
74HCK0.85794875
75NTRK20.85598130
76MAP3K70.84797580
77IKBKE0.81158774
78HIPK20.81110619
79CAMK2G0.80441905
80PRKD20.80389591
81MAPKAPK30.79364703
82TLK10.79271875
83TEC0.78010907
84MAPK120.76674620
85TIE10.75724279
86PIM10.75511483
87EEF2K0.75012895
88BRAF0.72161744
89TRIB30.72021622
90CSK0.71760618
91PIK3CG0.69852414
92SGK4940.69164032
93SGK2230.69164032
94MAP2K60.68763198
95JAK20.68652599
96SIK10.68492841
97SGK10.68392198
98SGK20.68096898
99CAMK2A0.67294615
100MAP3K140.65856445
101MAPK110.65584624
102PAK30.65400917
103PRKG20.64593453
104NEK10.64002710
105PRKCH0.61407794
106KSR10.60455400
107NME10.60154125
108IRAK10.59994531
109MAP2K30.59939609
110MAPK130.59169454
111MAP2K20.58659271
112KIT0.57598839
113EIF2AK10.57393489
114LCK0.56104464
115CCNB10.56046012
116CASK0.55201964
117ERN10.53090012
118FGFR40.52785306
119PDK30.52766037
120PDK40.52766037
121PRKAA10.52590731
122BRSK10.52162330
123TGFBR20.52049089
124CAMK40.51700523
125PRKACG0.50395154
126LYN0.49867793
127GRK60.49746491
128IRAK20.49514930
129PTK2B0.49500117
130SGK30.49334286
131DYRK1A0.48926793
132PRKCZ0.48889120
133MAP3K60.48719262
134CAMK2D0.45878507
135STK240.45744999
136ITK0.45537558
137MARK30.45179387
138MAPK100.43872369
139OXSR10.43827533
140ADRBK10.43297781
141RPS6KA20.43042434
142PRKAA20.42816069
143PRKACA0.42762348
144CAMK2B0.40946129
145MAPK40.40810747
146FRK0.40604421
147IKBKB0.40020673
148ADRBK20.39424062
149CDC42BPA0.39217519
150PTK60.38167820
151FGR0.38133573
152TXK0.37838002

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.18962003
2Nitrogen metabolism_Homo sapiens_hsa009103.09379161
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71990744
4Arginine biosynthesis_Homo sapiens_hsa002202.28494632
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23663032
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13343551
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05011190
8Fatty acid degradation_Homo sapiens_hsa000712.01968355
9Butanoate metabolism_Homo sapiens_hsa006502.00718290
10Non-small cell lung cancer_Homo sapiens_hsa052231.99394105
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.97302622
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96579141
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.95398878
14B cell receptor signaling pathway_Homo sapiens_hsa046621.90218734
15Synaptic vesicle cycle_Homo sapiens_hsa047211.83488795
16Propanoate metabolism_Homo sapiens_hsa006401.81564149
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75135600
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74757840
19Nicotine addiction_Homo sapiens_hsa050331.69076064
20Tryptophan metabolism_Homo sapiens_hsa003801.68776486
21Bile secretion_Homo sapiens_hsa049761.67120886
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.62243492
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58368422
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56304005
25Other glycan degradation_Homo sapiens_hsa005111.54461191
26Pyruvate metabolism_Homo sapiens_hsa006201.53613286
27VEGF signaling pathway_Homo sapiens_hsa043701.53562971
28Inositol phosphate metabolism_Homo sapiens_hsa005621.52345032
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50700940
30Peroxisome_Homo sapiens_hsa041461.50127074
31Platelet activation_Homo sapiens_hsa046111.47507693
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46266748
33Osteoclast differentiation_Homo sapiens_hsa043801.45398015
34Complement and coagulation cascades_Homo sapiens_hsa046101.44838197
35Chronic myeloid leukemia_Homo sapiens_hsa052201.43485923
36GABAergic synapse_Homo sapiens_hsa047271.43190790
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42139719
38Acute myeloid leukemia_Homo sapiens_hsa052211.41275794
39Glioma_Homo sapiens_hsa052141.40984494
40mTOR signaling pathway_Homo sapiens_hsa041501.40842569
41Fatty acid metabolism_Homo sapiens_hsa012121.33841791
42beta-Alanine metabolism_Homo sapiens_hsa004101.32746864
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30675515
44GnRH signaling pathway_Homo sapiens_hsa049121.30351600
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30175195
46Fatty acid biosynthesis_Homo sapiens_hsa000611.29746928
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.29447838
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29073061
49PPAR signaling pathway_Homo sapiens_hsa033201.28932752
50T cell receptor signaling pathway_Homo sapiens_hsa046601.26546047
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25447239
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25087326
53Pancreatic cancer_Homo sapiens_hsa052121.24229533
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22710239
55FoxO signaling pathway_Homo sapiens_hsa040681.21433314
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18872978
57Sulfur metabolism_Homo sapiens_hsa009201.18050214
58Sphingolipid signaling pathway_Homo sapiens_hsa040711.17503245
59Choline metabolism in cancer_Homo sapiens_hsa052311.17409209
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16787350
61Olfactory transduction_Homo sapiens_hsa047401.16641377
62Insulin secretion_Homo sapiens_hsa049111.14820217
63Phospholipase D signaling pathway_Homo sapiens_hsa040721.13605831
64Starch and sucrose metabolism_Homo sapiens_hsa005001.13371956
65Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12352738
66Circadian entrainment_Homo sapiens_hsa047131.11572843
67Neurotrophin signaling pathway_Homo sapiens_hsa047221.11370703
68Insulin resistance_Homo sapiens_hsa049311.08568046
69Folate biosynthesis_Homo sapiens_hsa007901.06495366
70Prolactin signaling pathway_Homo sapiens_hsa049171.06000171
71ABC transporters_Homo sapiens_hsa020101.05973518
72Salivary secretion_Homo sapiens_hsa049701.03899601
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.03850992
74Chemical carcinogenesis_Homo sapiens_hsa052041.03704293
75Morphine addiction_Homo sapiens_hsa050321.03405319
76Carbon metabolism_Homo sapiens_hsa012001.03230748
77Maturity onset diabetes of the young_Homo sapiens_hsa049501.02798591
78Phenylalanine metabolism_Homo sapiens_hsa003601.01590445
79Jak-STAT signaling pathway_Homo sapiens_hsa046301.01053797
80Long-term potentiation_Homo sapiens_hsa047201.00987656
81Taste transduction_Homo sapiens_hsa047421.00316483
82Chemokine signaling pathway_Homo sapiens_hsa040620.99146848
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99069286
84Glutamatergic synapse_Homo sapiens_hsa047240.98910613
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98820796
86Renal cell carcinoma_Homo sapiens_hsa052110.97567285
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96651907
88Biosynthesis of amino acids_Homo sapiens_hsa012300.95996977
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94761862
90Leishmaniasis_Homo sapiens_hsa051400.93706503
91Tuberculosis_Homo sapiens_hsa051520.93465915
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93410129
93Sulfur relay system_Homo sapiens_hsa041220.92665903
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90335970
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89767094
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.88017223
97Histidine metabolism_Homo sapiens_hsa003400.87475248
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86266941
99Tyrosine metabolism_Homo sapiens_hsa003500.86123377
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.85662778
101Glycerolipid metabolism_Homo sapiens_hsa005610.84757093
102Caffeine metabolism_Homo sapiens_hsa002320.84502741
103Amphetamine addiction_Homo sapiens_hsa050310.83997127
104African trypanosomiasis_Homo sapiens_hsa051430.83210414
105Collecting duct acid secretion_Homo sapiens_hsa049660.82602895
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81473636
107Oxidative phosphorylation_Homo sapiens_hsa001900.81247567
108Regulation of autophagy_Homo sapiens_hsa041400.81206211
109Selenocompound metabolism_Homo sapiens_hsa004500.80870899
110Staphylococcus aureus infection_Homo sapiens_hsa051500.79299843
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79136278
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78437769
113Dopaminergic synapse_Homo sapiens_hsa047280.78347778
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78123672
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.78097720
116Malaria_Homo sapiens_hsa051440.77573723
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77069900
118Dorso-ventral axis formation_Homo sapiens_hsa043200.76468006
119Insulin signaling pathway_Homo sapiens_hsa049100.76394503
120Endometrial cancer_Homo sapiens_hsa052130.75806557
121Cardiac muscle contraction_Homo sapiens_hsa042600.75052410
122Estrogen signaling pathway_Homo sapiens_hsa049150.74768614
123Gastric acid secretion_Homo sapiens_hsa049710.74572158
124Parkinsons disease_Homo sapiens_hsa050120.73996701
125AMPK signaling pathway_Homo sapiens_hsa041520.73977133
126Fat digestion and absorption_Homo sapiens_hsa049750.73785035
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71430943
128ErbB signaling pathway_Homo sapiens_hsa040120.71415828
129Hepatitis C_Homo sapiens_hsa051600.71041671
130TNF signaling pathway_Homo sapiens_hsa046680.71022163
131Fatty acid elongation_Homo sapiens_hsa000620.69536585
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.68930451
133Vitamin B6 metabolism_Homo sapiens_hsa007500.67742991
134Pancreatic secretion_Homo sapiens_hsa049720.67145282
135Retinol metabolism_Homo sapiens_hsa008300.67085131
136Sphingolipid metabolism_Homo sapiens_hsa006000.66681992
137Measles_Homo sapiens_hsa051620.64228274
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64137359
139Renin secretion_Homo sapiens_hsa049240.63963414
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63435106
141Glucagon signaling pathway_Homo sapiens_hsa049220.62908043
142Alzheimers disease_Homo sapiens_hsa050100.62294398
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62285691
144Cholinergic synapse_Homo sapiens_hsa047250.61577943
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.60859513
146Calcium signaling pathway_Homo sapiens_hsa040200.60660301
147Hepatitis B_Homo sapiens_hsa051610.60334744
148Toxoplasmosis_Homo sapiens_hsa051450.60138160
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59510612
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58704132
151cAMP signaling pathway_Homo sapiens_hsa040240.57908249
152Ovarian steroidogenesis_Homo sapiens_hsa049130.57183845
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57111898
154Fructose and mannose metabolism_Homo sapiens_hsa000510.56246396
155Renin-angiotensin system_Homo sapiens_hsa046140.55115463
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.55010945
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.54554305
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54469741
159MAPK signaling pathway_Homo sapiens_hsa040100.53899357
160Long-term depression_Homo sapiens_hsa047300.52310909
161Oxytocin signaling pathway_Homo sapiens_hsa049210.51993338
162Serotonergic synapse_Homo sapiens_hsa047260.50675828
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.50082575
164Galactose metabolism_Homo sapiens_hsa000520.49857594
165Thyroid hormone synthesis_Homo sapiens_hsa049180.46781851
166Type II diabetes mellitus_Homo sapiens_hsa049300.45598952
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45492563
168Metabolic pathways_Homo sapiens_hsa011000.43001173
169Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42619445

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