FBXW10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.72290174
2cilium movement (GO:0003341)9.70966225
3reproduction (GO:0000003)9.39294053
4spermatid development (GO:0007286)9.31610549
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73884655
6piRNA metabolic process (GO:0034587)8.52246542
7regulation of cilium movement (GO:0003352)8.23717709
8poly(A)+ mRNA export from nucleus (GO:0016973)8.23713986
9phosphatidylinositol acyl-chain remodeling (GO:0036149)8.18094020
10male meiosis (GO:0007140)8.03448046
11single fertilization (GO:0007338)7.66594258
12synaptonemal complex organization (GO:0070193)7.52175469
13phosphatidylserine acyl-chain remodeling (GO:0036150)7.36748074
14synaptonemal complex assembly (GO:0007130)7.14985033
15sperm capacitation (GO:0048240)6.97229437
16modulation by virus of host process (GO:0019054)6.83201985
17negative regulation of inclusion body assembly (GO:0090084)6.59214221
18fertilization (GO:0009566)6.44848720
19ventricular system development (GO:0021591)6.27751869
20spermatogenesis (GO:0007283)6.19700049
21male gamete generation (GO:0048232)6.17832605
22phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.91374080
23regulation of translational fidelity (GO:0006450)5.80402493
24gamete generation (GO:0007276)5.68655640
25microtubule depolymerization (GO:0007019)5.59756690
26organic cation transport (GO:0015695)5.56042542
27male meiosis I (GO:0007141)5.47869249
28DNA methylation involved in gamete generation (GO:0043046)5.35416701
29regulation of inclusion body assembly (GO:0090083)5.31033816
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.30216891
31germ cell development (GO:0007281)5.29188108
32phosphatidylcholine acyl-chain remodeling (GO:0036151)5.01699395
33modulation by symbiont of host cellular process (GO:0044068)5.00782452
34chromosome organization involved in meiosis (GO:0070192)4.98847731
35response to pheromone (GO:0019236)4.92161102
36calcium ion-dependent exocytosis (GO:0017156)4.90211573
37cell recognition (GO:0008037)4.87735507
38negative regulation of viral entry into host cell (GO:0046597)4.80202874
39regulation of microtubule-based movement (GO:0060632)4.71352978
40neutrophil activation involved in immune response (GO:0002283)4.64719830
41meiotic nuclear division (GO:0007126)4.63331017
42microtubule severing (GO:0051013)4.55027688
43multicellular organismal reproductive process (GO:0048609)4.46448710
44seminiferous tubule development (GO:0072520)4.38699641
45left/right pattern formation (GO:0060972)4.36733162
46meiosis I (GO:0007127)4.34943488
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.31938939
48axoneme assembly (GO:0035082)4.27297004
49spermatid nucleus differentiation (GO:0007289)4.17682279
50meiotic cell cycle (GO:0051321)4.15744715
51phosphatidylserine metabolic process (GO:0006658)4.04213623
52cellular ketone body metabolic process (GO:0046950)3.95465849
53monoubiquitinated protein deubiquitination (GO:0035520)3.88660777
54basic amino acid transport (GO:0015802)3.88257579
55regulation of translational elongation (GO:0006448)3.85939696
56glycerol ether metabolic process (GO:0006662)3.76225296
57negative regulation of viral release from host cell (GO:1902187)3.71405940
58regulation of viral entry into host cell (GO:0046596)3.71375885
59protein localization to cilium (GO:0061512)3.70444823
60chromosome condensation (GO:0030261)3.68637443
61DNA packaging (GO:0006323)3.67156080
62behavioral response to nicotine (GO:0035095)3.66048704
63genitalia morphogenesis (GO:0035112)3.63850411
64multicellular organismal development (GO:0007275)3.59860258
65L-methionine salvage (GO:0071267)3.58714079
66L-methionine biosynthetic process (GO:0071265)3.58714079
67amino acid salvage (GO:0043102)3.58714079
68ketone body metabolic process (GO:1902224)3.56214725
69chaperone-mediated protein complex assembly (GO:0051131)3.53484172
70intraciliary transport (GO:0042073)3.52283580
71S-adenosylmethionine metabolic process (GO:0046500)3.50282731
72protein polyglutamylation (GO:0018095)3.48563440
73ether metabolic process (GO:0018904)3.46003821
74cilium organization (GO:0044782)3.42502950
75GTP biosynthetic process (GO:0006183)3.32564935
76microtubule-based movement (GO:0007018)3.28113241
77indolalkylamine metabolic process (GO:0006586)3.27133216
78nucleoside diphosphate phosphorylation (GO:0006165)3.26831065
79cilium assembly (GO:0042384)3.22413430
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.17237551
81alditol phosphate metabolic process (GO:0052646)3.14660807
82photoreceptor cell maintenance (GO:0045494)3.12494771
83gene silencing by RNA (GO:0031047)3.11455999
84cilium morphogenesis (GO:0060271)3.11438961
85cellular component assembly involved in morphogenesis (GO:0010927)3.10107271
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.09628858
87synapsis (GO:0007129)3.05838245
88regulation of spindle checkpoint (GO:0090231)3.05626956
89protein refolding (GO:0042026)3.04882841
90meiotic cell cycle process (GO:1903046)3.03971477
91protein K11-linked deubiquitination (GO:0035871)2.99677623
92negative regulation of telomere maintenance (GO:0032205)2.99427879
93gamma-aminobutyric acid transport (GO:0015812)2.97818771
94UTP biosynthetic process (GO:0006228)2.93893724
95left/right axis specification (GO:0070986)2.90229077
96carnitine transport (GO:0015879)2.90054794
97amino-acid betaine transport (GO:0015838)2.90054794
98negative regulation of organelle assembly (GO:1902116)2.88718288
99brain morphogenesis (GO:0048854)2.87710122
100positive regulation of fatty acid transport (GO:2000193)2.85405733
101regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.84796110
102mitotic sister chromatid cohesion (GO:0007064)2.84202752
103carnitine transmembrane transport (GO:1902603)2.82438995
104negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.81728139
105regulation of centriole replication (GO:0046599)2.81011756
106centriole assembly (GO:0098534)2.80213282
107nucleus organization (GO:0006997)2.79571911
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79195625
109amyloid precursor protein catabolic process (GO:0042987)2.78333019
110regulation of regulatory T cell differentiation (GO:0045589)2.77395431
111polyol catabolic process (GO:0046174)2.76497571
112nuclear pore complex assembly (GO:0051292)2.75055636
113L-fucose metabolic process (GO:0042354)2.74832097
114L-fucose catabolic process (GO:0042355)2.74832097
115fucose catabolic process (GO:0019317)2.74832097
116indole-containing compound catabolic process (GO:0042436)2.73750404
117indolalkylamine catabolic process (GO:0046218)2.73750404
118tryptophan catabolic process (GO:0006569)2.73750404
119alditol metabolic process (GO:0019400)2.72934859
120smoothened signaling pathway (GO:0007224)2.72801824
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72084407
122lactate metabolic process (GO:0006089)2.71345249
123microtubule polymerization or depolymerization (GO:0031109)2.70833340
124single strand break repair (GO:0000012)2.69997085
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69331324
126photoreceptor cell development (GO:0042461)2.67210732
127vesicle targeting (GO:0006903)2.66998419
128regulation of viral release from host cell (GO:1902186)2.66205183
129dorsal/ventral neural tube patterning (GO:0021904)2.65915237
130centriole replication (GO:0007099)2.65755952
131neutrophil activation (GO:0042119)2.65549166
132UTP metabolic process (GO:0046051)2.65065497
133platelet dense granule organization (GO:0060155)2.64869019
134glycolytic process (GO:0006096)2.62672048
135cellular defense response (GO:0006968)2.62320073
136base-excision repair, AP site formation (GO:0006285)2.60459931
137positive regulation of meiosis (GO:0045836)2.60208678
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59882431
139energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59673264
140ATP synthesis coupled proton transport (GO:0015986)2.59673264
141activated T cell proliferation (GO:0050798)2.58712583
142primary amino compound metabolic process (GO:1901160)2.58707631
143detection of light stimulus involved in visual perception (GO:0050908)2.58449953
144detection of light stimulus involved in sensory perception (GO:0050962)2.58449953
145positive regulation of icosanoid secretion (GO:0032305)2.58176101
146negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.57990033
147positive regulation of T cell mediated cytotoxicity (GO:0001916)2.57126392
148cytidine metabolic process (GO:0046087)2.56251546
149cytidine catabolic process (GO:0006216)2.56251546
150cytidine deamination (GO:0009972)2.56251546
151indole-containing compound metabolic process (GO:0042430)2.55760446
152modulation by virus of host morphology or physiology (GO:0019048)2.55049152
153somite development (GO:0061053)2.52245481
154RNA destabilization (GO:0050779)2.51506547
155cornea development in camera-type eye (GO:0061303)2.50051187
156positive regulation of tolerance induction (GO:0002645)2.49897198
157kynurenine metabolic process (GO:0070189)2.49443871
158positive regulation of macrophage activation (GO:0043032)2.46872844
159regulation of meiosis I (GO:0060631)2.37573241
160gene silencing (GO:0016458)2.36145449
161glycerol metabolic process (GO:0006071)2.35298541
162fusion of sperm to egg plasma membrane (GO:0007342)13.6957584
163cilium or flagellum-dependent cell motility (GO:0001539)13.6261944
164sperm motility (GO:0030317)12.7508232
165cell wall macromolecule metabolic process (GO:0044036)11.5857303
166cell wall macromolecule catabolic process (GO:0016998)11.5857303
167acrosome assembly (GO:0001675)11.5438851
168axonemal dynein complex assembly (GO:0070286)11.5175665
169multicellular organism reproduction (GO:0032504)11.4135382
170sperm-egg recognition (GO:0035036)11.3980656
171acrosome reaction (GO:0007340)10.9470230
172epithelial cilium movement (GO:0003351)10.5249403
173plasma membrane fusion (GO:0045026)10.3965910
174cell-cell recognition (GO:0009988)10.2312024
175binding of sperm to zona pellucida (GO:0007339)10.1966861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.92912690
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.55953478
3EZH2_22144423_ChIP-Seq_EOC_Human4.10900621
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.90136195
5IGF1R_20145208_ChIP-Seq_DFB_Human3.19911358
6GBX2_23144817_ChIP-Seq_PC3_Human2.76871220
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69808100
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55038460
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.51670456
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42546773
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37872047
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36919729
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15047496
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03250931
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97788864
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.92211943
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87993468
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87484925
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.87027607
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84674075
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84433020
22VDR_22108803_ChIP-Seq_LS180_Human1.83739449
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83347332
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.81814842
25P300_19829295_ChIP-Seq_ESCs_Human1.77799895
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76587284
27ZNF274_21170338_ChIP-Seq_K562_Hela1.75249183
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.75044131
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71873513
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71636101
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71262915
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70567656
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.68146502
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66112639
35STAT1_17558387_ChIP-Seq_HELA_Human1.64050685
36EWS_26573619_Chip-Seq_HEK293_Human1.63667296
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63572479
38TP53_22573176_ChIP-Seq_HFKS_Human1.63306146
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61499908
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61441759
41ER_23166858_ChIP-Seq_MCF-7_Human1.60899509
42TAF15_26573619_Chip-Seq_HEK293_Human1.59745587
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.58121168
44AR_25329375_ChIP-Seq_VCAP_Human1.58036656
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.57740588
46BCAT_22108803_ChIP-Seq_LS180_Human1.57717518
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56023612
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54781380
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.53216143
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51722830
51HOXB7_26014856_ChIP-Seq_BT474_Human1.49536638
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.48024380
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47548291
54CBP_20019798_ChIP-Seq_JUKART_Human1.47548291
55FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45254486
56KDM2B_26808549_Chip-Seq_REH_Human1.43122658
57GATA3_21867929_ChIP-Seq_CD8_Mouse1.42628075
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.42585814
59TCF4_22108803_ChIP-Seq_LS180_Human1.42478602
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42025886
61ERA_21632823_ChIP-Seq_H3396_Human1.41617192
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41592998
63CDX2_22108803_ChIP-Seq_LS180_Human1.40837248
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40431152
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38684092
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.37974097
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37904220
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37589115
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37073964
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36926151
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36552815
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34749770
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34239323
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.34239323
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.33764471
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32657359
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32229603
78AR_21572438_ChIP-Seq_LNCaP_Human1.30429890
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28705869
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.28518290
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.28011454
82AR_20517297_ChIP-Seq_VCAP_Human1.27614509
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.27276585
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26756106
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25664974
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25086622
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.24953920
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.24644996
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24400813
90* TCF4_23295773_ChIP-Seq_U87_Human1.23846834
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.22521978
92SMAD4_21799915_ChIP-Seq_A2780_Human1.21952641
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21493517
94NANOG_19829295_ChIP-Seq_ESCs_Human1.21427511
95SOX2_19829295_ChIP-Seq_ESCs_Human1.21427511
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21385074
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21230928
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.20621048
99STAT3_23295773_ChIP-Seq_U87_Human1.20268327
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20078708
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20078708
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18238041
103GF1_26923725_Chip-Seq_HPCs_Mouse1.17756079
104P53_22387025_ChIP-Seq_ESCs_Mouse1.16660828
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.16560828
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.15810186
107MYC_18940864_ChIP-ChIP_HL60_Human1.15687827
108NCOR_22424771_ChIP-Seq_293T_Human1.15680762
109P300_18555785_Chip-Seq_ESCs_Mouse1.15559587
110FOXH1_21741376_ChIP-Seq_EPCs_Human1.15526412
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.14957160
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14169519
113RNF2_27304074_Chip-Seq_NSC_Mouse1.13671566
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13339095
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.13146652
116P53_21459846_ChIP-Seq_SAOS-2_Human1.12732087
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12675130
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12581312
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11984249
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11971284
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11657946
122* MYC_19829295_ChIP-Seq_ESCs_Human1.11511169
123* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11259461
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.11194222
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.10221424
126REST_21632747_ChIP-Seq_MESCs_Mouse1.10111583
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09023324
128FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08320329
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06634890
130CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06598603
131* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06265627
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04909672
133PU1_27457419_Chip-Seq_LIVER_Mouse1.04474080
134IRF1_19129219_ChIP-ChIP_H3396_Human1.04230123
135GATA3_26560356_Chip-Seq_TH2_Human1.02385854
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02155185
137TAF2_19829295_ChIP-Seq_ESCs_Human1.01816208
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01735659
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.01667554
140* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00620232
141* NANOG_20526341_ChIP-Seq_ESCs_Human1.00536627
142RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99013653
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98828863
144RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98623813
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98195994
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98085899
147SPI1_26923725_Chip-Seq_HPCs_Mouse0.97504891
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.97197321
149RUNX2_22187159_ChIP-Seq_PCA_Human0.96821818
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.96750242
151CTCF_18555785_Chip-Seq_ESCs_Mouse0.96717158
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96509290
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95168866
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.95112359
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94747047
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94704128
157ELK1_19687146_ChIP-ChIP_HELA_Human0.94536261
158RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93695298
159ERG_20517297_ChIP-Seq_VCAP_Human0.93574215
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93379446
161* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93377845
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93308423
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92848057
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89936015
165STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89868668
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88675903
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.88598210
168FUS_26573619_Chip-Seq_HEK293_Human0.88476252
169* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87741210
170SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87643384
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.87277253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.98749957
2MP0001929_abnormal_gametogenesis5.49908274
3MP0008877_abnormal_DNA_methylation4.56200801
4MP0006054_spinal_hemorrhage3.91781843
5MP0002210_abnormal_sex_determination3.60764898
6MP0002653_abnormal_ependyma_morphology3.26626260
7MP0002161_abnormal_fertility/fecundity3.20606603
8MP0001145_abnormal_male_reproductive3.02809683
9MP0003195_calcinosis3.02433666
10MP0002138_abnormal_hepatobiliary_system2.72150405
11MP0000653_abnormal_sex_gland2.58633111
12MP0008875_abnormal_xenobiotic_pharmacok2.47300417
13MP0004147_increased_porphyrin_level2.43147630
14MP0005670_abnormal_white_adipose2.32904823
15MP0005623_abnormal_meninges_morphology2.15267251
16MP0001486_abnormal_startle_reflex2.12343163
17MP0004145_abnormal_muscle_electrophysio2.05612304
18MP0005171_absent_coat_pigmentation2.01919485
19MP0005410_abnormal_fertilization15.6405832
20MP0004885_abnormal_endolymph1.87470648
21MP0002638_abnormal_pupillary_reflex1.82265814
22MP0005645_abnormal_hypothalamus_physiol1.80349872
23MP0003136_yellow_coat_color1.76343624
24MP0006072_abnormal_retinal_apoptosis1.76302743
25MP0003880_abnormal_central_pattern1.72952479
26MP0001968_abnormal_touch/_nociception1.68764239
27MP0001727_abnormal_embryo_implantation1.65407116
28MP0001485_abnormal_pinna_reflex1.63882696
29MP0002837_dystrophic_cardiac_calcinosis1.57876862
30MP0000372_irregular_coat_pigmentation1.54433855
31MP0002160_abnormal_reproductive_system1.52553983
32MP0002277_abnormal_respiratory_mucosa1.52095835
33MP0002876_abnormal_thyroid_physiology1.47610738
34MP0006292_abnormal_olfactory_placode1.40409555
35MP0009745_abnormal_behavioral_response1.34952782
36MP0010386_abnormal_urinary_bladder1.32942781
37MP0005084_abnormal_gallbladder_morpholo1.31984829
38MP0005085_abnormal_gallbladder_physiolo1.31510044
39MP0008872_abnormal_physiological_respon1.30693400
40MP0005360_urolithiasis1.29969663
41MP0002282_abnormal_trachea_morphology1.29782100
42MP0008058_abnormal_DNA_repair1.29417454
43MP0002254_reproductive_system_inflammat1.25985689
44MP0003646_muscle_fatigue1.22039556
45MP0004142_abnormal_muscle_tone1.18152706
46MP0000631_abnormal_neuroendocrine_gland1.16518235
47MP0006276_abnormal_autonomic_nervous1.14748835
48MP0002272_abnormal_nervous_system1.14117172
49MP0009046_muscle_twitch1.12495611
50MP0010094_abnormal_chromosome_stability1.11391844
51MP0000647_abnormal_sebaceous_gland1.09919473
52MP0005647_abnormal_sex_gland1.08527664
53MP0001502_abnormal_circadian_rhythm1.06850988
54MP0003567_abnormal_fetal_cardiomyocyte1.05578695
55MP0009785_altered_susceptibility_to1.03880854
56MP0001501_abnormal_sleep_pattern1.03398563
57MP0001765_abnormal_ion_homeostasis1.01676265
58MP0008057_abnormal_DNA_replication1.01313239
59MP0004233_abnormal_muscle_weight0.98898165
60MP0000427_abnormal_hair_cycle0.98746727
61MP0000613_abnormal_salivary_gland0.96432995
62MP0003137_abnormal_impulse_conducting0.95933433
63MP0002229_neurodegeneration0.95929728
64MP0008995_early_reproductive_senescence0.94302653
65MP0005423_abnormal_somatic_nervous0.93628328
66MP0002064_seizures0.93195279
67MP0002938_white_spotting0.93149106
68MP0001919_abnormal_reproductive_system0.89539930
69MP0003252_abnormal_bile_duct0.89294763
70MP0005195_abnormal_posterior_eye0.88460807
71MP0002928_abnormal_bile_duct0.88415803
72MP0003787_abnormal_imprinting0.88032824
73MP0001984_abnormal_olfaction0.86679384
74MP0002693_abnormal_pancreas_physiology0.86615869
75MP0005389_reproductive_system_phenotype0.85442688
76MP0002148_abnormal_hypersensitivity_rea0.82259328
77MP0003436_decreased_susceptibility_to0.81757985
78MP0008789_abnormal_olfactory_epithelium0.79422801
79MP0004043_abnormal_pH_regulation0.79170834
80MP0005397_hematopoietic_system_phenotyp0.78932939
81MP0001545_abnormal_hematopoietic_system0.78932939
82MP0002557_abnormal_social/conspecific_i0.78794002
83MP0002752_abnormal_somatic_nervous0.78470127
84MP0004808_abnormal_hematopoietic_stem0.76693276
85MP0001529_abnormal_vocalization0.76455800
86MP0003635_abnormal_synaptic_transmissio0.76204785
87MP0003329_amyloid_beta_deposits0.75522414
88MP0002405_respiratory_system_inflammati0.75001830
89MP0000026_abnormal_inner_ear0.74975930
90MP0002009_preneoplasia0.74041963
91MP0000569_abnormal_digit_pigmentation0.73961437
92MP0001970_abnormal_pain_threshold0.73014849
93MP0008775_abnormal_heart_ventricle0.72540149
94MP0009278_abnormal_bone_marrow0.70215755
95MP0005365_abnormal_bile_salt0.67869036
96MP0005377_hearing/vestibular/ear_phenot0.67078422
97MP0003878_abnormal_ear_physiology0.67078422
98MP0003011_delayed_dark_adaptation0.62929465
99MP0001873_stomach_inflammation0.59378201
100MP0000358_abnormal_cell_content/0.58265210
101MP0000685_abnormal_immune_system0.57092461
102MP0008007_abnormal_cellular_replicative0.55063832
103MP0003111_abnormal_nucleus_morphology0.53016268
104MP0002234_abnormal_pharynx_morphology0.50327442
105MP0002102_abnormal_ear_morphology0.48343480
106MP0003115_abnormal_respiratory_system0.48158285
107MP0003786_premature_aging0.47757888
108MP0003699_abnormal_female_reproductive0.46825201
109MP0005075_abnormal_melanosome_morpholog0.44651407
110MP0001293_anophthalmia0.44309653
111MP0005636_abnormal_mineral_homeostasis0.43528208
112MP0009115_abnormal_fat_cell0.43044766
113MP0002736_abnormal_nociception_after0.42140496
114MP0003763_abnormal_thymus_physiology0.41600240
115MP0005257_abnormal_intraocular_pressure0.41091035
116MP0005174_abnormal_tail_pigmentation0.40217158
117MP0001835_abnormal_antigen_presentation0.39564170
118MP0001119_abnormal_female_reproductive0.39558905
119MP0001764_abnormal_homeostasis0.39366814
120MP0003950_abnormal_plasma_membrane0.36252604
121MP0001440_abnormal_grooming_behavior0.36091093
122MP0001348_abnormal_lacrimal_gland0.35030080
123MP0001790_abnormal_immune_system0.34968940
124MP0005387_immune_system_phenotype0.34968940
125MP0002132_abnormal_respiratory_system0.33195212
126MP0005646_abnormal_pituitary_gland0.32596861
127MP0001324_abnormal_eye_pigmentation0.31932174
128MP0008004_abnormal_stomach_pH0.31434488
129MP0002723_abnormal_immune_serum0.30548831
130MP0001851_eye_inflammation0.29797880
131MP0004742_abnormal_vestibular_system0.29329775
132MP0010307_abnormal_tumor_latency0.29078746
133MP0002398_abnormal_bone_marrow0.28194489
134MP0001986_abnormal_taste_sensitivity0.27789385
135MP0003959_abnormal_lean_body0.27646443
136MP0000703_abnormal_thymus_morphology0.26210204
137MP0005391_vision/eye_phenotype0.26041204
138MP0003943_abnormal_hepatobiliary_system0.25753827
139MP0004036_abnormal_muscle_relaxation0.25556857
140MP0005666_abnormal_adipose_tissue0.25371088
141MP0004134_abnormal_chest_morphology0.24570756
142MP0004133_heterotaxia0.24345166
143MP0000313_abnormal_cell_death0.23384346
144MP0001800_abnormal_humoral_immune0.22723484
145MP0002971_abnormal_brown_adipose0.22055186
146MP0002269_muscular_atrophy0.21953234
147MP0003077_abnormal_cell_cycle0.21829520
148MP0006082_CNS_inflammation0.21525763
149MP0005253_abnormal_eye_physiology0.21481050
150MP0003633_abnormal_nervous_system0.21279379
151MP0002735_abnormal_chemical_nociception0.19489632
152MP0002452_abnormal_antigen_presenting0.19158356
153MP0002133_abnormal_respiratory_system0.19154822
154MP0005388_respiratory_system_phenotype0.19154822
155MP0002092_abnormal_eye_morphology0.19018227
156MP0005671_abnormal_response_to0.18785370
157MP0000689_abnormal_spleen_morphology0.18743574
158MP0003279_aneurysm0.18552412
159MP0005551_abnormal_eye_electrophysiolog0.17989229
160MP0003045_fibrosis0.17979180
161MP0004019_abnormal_vitamin_homeostasis0.17306847
162MP0002420_abnormal_adaptive_immunity0.16798702
163MP0000716_abnormal_immune_system0.16261332

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.79677295
2Abnormal respiratory epithelium morphology (HP:0012253)8.79677295
3Rhinitis (HP:0012384)8.26862707
4Abnormal ciliary motility (HP:0012262)8.24005190
5Agnosia (HP:0010524)8.06778209
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)7.90557415
7Chronic bronchitis (HP:0004469)7.54103949
8Nasal polyposis (HP:0100582)6.60694096
9Infertility (HP:0000789)5.97361201
10Abnormality of the nasal mucosa (HP:0000433)5.46493847
11Bronchiectasis (HP:0002110)5.03340383
12Disinhibition (HP:0000734)5.02373804
13Bronchitis (HP:0012387)4.87631920
14Nephronophthisis (HP:0000090)4.29475464
15Recurrent sinusitis (HP:0011108)3.87215629
16Inappropriate behavior (HP:0000719)3.69817043
17Axonal loss (HP:0003447)3.57042255
18Recurrent otitis media (HP:0000403)3.53888401
19Progressive external ophthalmoplegia (HP:0000590)3.43549877
20Male infertility (HP:0003251)3.42672746
21Abnormality of the renal medulla (HP:0100957)3.37110455
22Tubulointerstitial nephritis (HP:0001970)3.22158579
23Renal cortical cysts (HP:0000803)3.18301457
24Abnormal spermatogenesis (HP:0008669)3.17325802
25Recurrent bronchitis (HP:0002837)3.09983901
26Tubular atrophy (HP:0000092)2.98312458
27Attenuation of retinal blood vessels (HP:0007843)2.98122369
28Personality changes (HP:0000751)2.89964177
29Absent thumb (HP:0009777)2.89114592
30Congenital stationary night blindness (HP:0007642)2.86347855
31Molar tooth sign on MRI (HP:0002419)2.77953864
32Abnormality of midbrain morphology (HP:0002418)2.77953864
33Mask-like facies (HP:0000298)2.74287390
34Polyphagia (HP:0002591)2.69412851
35Neck muscle weakness (HP:0000467)2.69164616
36Hypoplasia of the uterus (HP:0000013)2.62883720
37Tubulointerstitial abnormality (HP:0001969)2.53426400
38Aplasia/hypoplasia of the uterus (HP:0008684)2.48313575
39Medial flaring of the eyebrow (HP:0010747)2.43944492
40Male pseudohermaphroditism (HP:0000037)2.40427760
41Congenital, generalized hypertrichosis (HP:0004540)2.39021789
42Sclerocornea (HP:0000647)2.37719510
43Postaxial foot polydactyly (HP:0001830)2.32734286
44Azoospermia (HP:0000027)2.31245608
45Abnormal rod and cone electroretinograms (HP:0008323)2.30474652
46Decreased circulating renin level (HP:0003351)2.28841459
47Occipital encephalocele (HP:0002085)2.25856860
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.24586349
49Type II lissencephaly (HP:0007260)2.24174675
50Congenital hepatic fibrosis (HP:0002612)2.23028432
51Gonadotropin excess (HP:0000837)2.20547198
52Asplenia (HP:0001746)2.18543516
53Fibular hypoplasia (HP:0003038)2.14112951
54Bone cyst (HP:0012062)2.12863884
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12280895
56Bile duct proliferation (HP:0001408)2.11829372
57Abnormal biliary tract physiology (HP:0012439)2.11829372
58Abnormality of the renal cortex (HP:0011035)2.09660538
59Impulsivity (HP:0100710)2.04668530
60Polydipsia (HP:0001959)2.03245445
61Abnormal drinking behavior (HP:0030082)2.03245445
62Stage 5 chronic kidney disease (HP:0003774)2.02781036
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1726554
64Dynein arm defect of respiratory motile cilia (HP:0012255)12.3336912
65Absent/shortened dynein arms (HP:0200106)12.3336912
66Abnormal respiratory motile cilium physiology (HP:0012261)10.0638986
67Generalized aminoaciduria (HP:0002909)1.98332562
68Abolished electroretinogram (ERG) (HP:0000550)1.97195460
69Tubulointerstitial fibrosis (HP:0005576)1.96375557
70Anencephaly (HP:0002323)1.95732260
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94562473
72Chronic sinusitis (HP:0011109)1.94250623
73Facial cleft (HP:0002006)1.93756780
74Abnormality of the renal collecting system (HP:0004742)1.90912881
75Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90598956
76Optic disc pallor (HP:0000543)1.88962554
77Abnormality of the lower motor neuron (HP:0002366)1.88825284
78Duplicated collecting system (HP:0000081)1.87756097
79Pancreatic fibrosis (HP:0100732)1.86047047
80Rib fusion (HP:0000902)1.85432121
81Chronic hepatic failure (HP:0100626)1.82893524
82IgG deficiency (HP:0004315)1.82188473
83Supernumerary spleens (HP:0009799)1.81979900
84Keratoconus (HP:0000563)1.81599009
85Increased corneal curvature (HP:0100692)1.81599009
86Abnormal neuron morphology (HP:0012757)1.80397577
87Abnormality of the motor neurons (HP:0002450)1.80397577
88Syncope (HP:0001279)1.79458969
89Acute necrotizing encephalopathy (HP:0006965)1.78464090
90Median cleft lip (HP:0000161)1.77609311
91Increased IgM level (HP:0003496)1.73843577
92Pendular nystagmus (HP:0012043)1.73495692
93Encephalitis (HP:0002383)1.71365856
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.70175438
95Cystic liver disease (HP:0006706)1.68718538
96Furrowed tongue (HP:0000221)1.68179099
97Renal dysplasia (HP:0000110)1.67875309
98Absent forearm bone (HP:0003953)1.66450157
99Aplasia involving forearm bones (HP:0009822)1.66450157
100Absent radius (HP:0003974)1.65136065
101Preaxial hand polydactyly (HP:0001177)1.65107563
102Oculomotor apraxia (HP:0000657)1.64504419
103Impaired proprioception (HP:0010831)1.64180217
104Hypothermia (HP:0002045)1.63931406
105Postaxial hand polydactyly (HP:0001162)1.63857119
106Abnormal eating behavior (HP:0100738)1.62411424
107Neurofibrillary tangles (HP:0002185)1.61356663
108Abnormality of dentin (HP:0010299)1.61260960
109External ophthalmoplegia (HP:0000544)1.60879569
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.59325396
111True hermaphroditism (HP:0010459)1.59281407
112Abnormality of renal excretion (HP:0011036)1.58509651
113Microglossia (HP:0000171)1.57848301
114Stomach cancer (HP:0012126)1.57619919
115Amyotrophic lateral sclerosis (HP:0007354)1.57405342
116Abnormality of the dental root (HP:0006486)1.57363579
117Taurodontia (HP:0000679)1.57363579
118Abnormality of permanent molar morphology (HP:0011071)1.57363579
119Short ribs (HP:0000773)1.54226789
120J-shaped sella turcica (HP:0002680)1.53912439
121Short thorax (HP:0010306)1.52702000
122Mitochondrial inheritance (HP:0001427)1.51748640
123Abnormality of renin-angiotensin system (HP:0000847)1.51690409
124Abnormality of molar (HP:0011077)1.50370849
125Abnormality of molar morphology (HP:0011070)1.50370849
126Nephropathy (HP:0000112)1.47729792
127Absent epiphyses (HP:0010577)1.46966307
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46966307
129Heterotopia (HP:0002282)1.45206376
130Absent frontal sinuses (HP:0002688)1.43406067
131Abnormality of the dental pulp (HP:0006479)1.41712272
132Abnormal gallbladder physiology (HP:0012438)1.41562714
133Cholecystitis (HP:0001082)1.41562714
134Dyschromatopsia (HP:0007641)1.41447384
135Broad distal phalanx of finger (HP:0009836)1.41261810
136Bell-shaped thorax (HP:0001591)1.40320316
137Pancreatic cysts (HP:0001737)1.38376607
138Spastic tetraparesis (HP:0001285)1.38342450
139Decreased central vision (HP:0007663)1.35193999
140Congenital primary aphakia (HP:0007707)1.35152220
141Aplasia/Hypoplasia of the lens (HP:0008063)1.35106601
142Abnormal urine output (HP:0012590)1.32961924
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.32275062
144Gait imbalance (HP:0002141)1.32183158
145Aplasia/Hypoplasia of the fibula (HP:0006492)1.25192420
146Easy fatigability (HP:0003388)1.24776862
147Polyuria (HP:0000103)1.24663539
148Deformed sella turcica (HP:0002681)1.24077793
149Hemiparesis (HP:0001269)1.20729926
150Choroideremia (HP:0001139)1.20394550
15111 pairs of ribs (HP:0000878)1.19551923
152Abnormality of ocular smooth pursuit (HP:0000617)1.17960261
153Hemorrhage of the eye (HP:0011885)1.17753734
154Nephrogenic diabetes insipidus (HP:0009806)1.17468432
155Upper motor neuron abnormality (HP:0002127)1.14225217
156Genital tract atresia (HP:0001827)1.10106396
157Degeneration of anterior horn cells (HP:0002398)1.09799653
158Abnormality of the anterior horn cell (HP:0006802)1.09799653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.48501428
2PDK48.48501428
3MAPK88.20372795
4PDK25.45239250
5TESK15.32595038
6TAOK34.52515757
7PRKD34.21572250
8BCKDK3.95368790
9EIF2AK13.89953864
10ICK3.84714937
11MAP4K23.58117061
12FRK3.13546674
13INSRR3.03622356
14PNCK2.79761307
15PTK2B2.46437365
16MAPK132.26153071
17WNK42.13337757
18MAPK152.07445804
19ZAK2.05016331
20MAP3K41.99213458
21STK391.92566388
22SCYL21.92362300
23NEK21.71657415
24MST41.62230942
25MAPKAPK31.61463624
26TLK11.56252047
27NUAK11.52745191
28STK381.42601898
29DYRK1B1.22121860
30CSNK1G31.21512095
31OXSR11.16828415
32CSNK1G11.10602518
33DYRK21.09496137
34DYRK31.08457918
35CSNK1A1L1.07479201
36DYRK1A1.07041908
37CSNK1G21.03988783
38PDK11.02307598
39GRK71.02296871
40ADRBK10.97356941
41WNK10.91200829
42TRPM70.89059067
43PASK0.87911911
44ACVR1B0.87731472
45WEE10.82981111
46EPHA30.80254862
47STK30.77483258
48PHKG20.75534991
49PHKG10.75534991
50CASK0.75481959
51TRIM280.74917384
52NME10.74005960
53TYRO30.73799743
54PRKCE0.72832724
55EEF2K0.72629873
56BMPR1B0.71343368
57IRAK10.70244773
58CCNB10.69428794
59BCR0.68384468
60MARK30.68327797
61PAK30.66287364
62STK160.64037284
63CDK190.63128579
64CAMK1G0.61514322
65CHEK20.59038374
66FGFR10.58950307
67VRK10.57900644
68RPS6KA50.57523081
69STK100.56178873
70PINK10.56144658
71RPS6KB20.53796737
72DAPK20.51568751
73TTK0.51377430
74IGF1R0.50786246
75ATR0.49359936
76PLK20.48618165
77OBSCN0.48583910
78CSNK1D0.47460604
79MUSK0.46052783
80MARK10.45756411
81MAP2K60.45580267
82IRAK40.45416187
83IKBKB0.44894704
84MAP4K10.44702224
85CDC70.44068795
86PDPK10.44044550
87CHEK10.43882618
88PKN10.43864970
89AKT30.43838313
90MAPK120.42703557
91ERBB30.40642763
92PRKCA0.40337466
93PRKACA0.40153796
94GRK50.39904871
95RIPK40.39245863
96PAK20.38467383
97TIE10.38397518
98LMTK20.37494334
99MATK0.37214737
100FLT30.37001122
101GRK60.36989593
102NEK90.36127691
103EPHA40.35227775
104CAMK2A0.34890250
105NLK0.34774320
106ITK0.34604941
107TXK0.34028840
108TNIK0.34018543
109ZAP700.33681595
110SIK20.33157991
111LYN0.32868628
112CSNK1A10.32262211
113PAK10.32037685
114ATM0.31190814
115PRKCZ0.30994771
116TNK20.30599446
117NTRK20.29875249
118MAPKAPK50.28553940
119CAMKK10.27462694
120CDK30.27155793
121PIK3CG0.26658390
122GRK10.26276034
123TGFBR20.24118333
124TEC0.23324384
125YES10.22692952
126PLK40.22560790
127TBK10.22514022
128MTOR0.22439934
129CDK120.22180570
130BRSK20.21908048
131TESK20.21459014
132PRKAA10.21379107
133PRKCG0.19595813
134PRKCQ0.18944223
135NEK60.18405498
136ADRBK20.16015107
137CSF1R0.15734006
138MARK20.15129487
139TGFBR10.15072782
140KIT0.14979397
141BRAF0.13758777
142PRKG20.13411027
143MAP2K70.12717022
144PLK10.12589595
145BTK0.12315233
146RPS6KB10.11875332
147CSK0.11788512
148STK110.09825300
149EGFR0.09464636
150CDK40.06728497
151PRKG10.04877337
152WNK30.04315314
153CSNK2A10.03357663
154CDK60.03335199
155GSK3B0.02819730
156LCK0.02769899
157MAPK10.01432290
158PRKACG0.01177667
159SYK0.01037316
160CLK10.00707833
161CSNK2A20.00648773
162CDK10.00628128
163CDK20.00621906
164MAP3K10-0.0140143
165PIM1-0.0127050
166PRKCB-0.0125292
167IRAK2-0.0121654
168STK38L-0.0107379
169BRSK1-0.0089290
170PRKCD-0.0026014

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.15866466
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97079967
3Pyruvate metabolism_Homo sapiens_hsa006203.61509162
4Fatty acid biosynthesis_Homo sapiens_hsa000613.45914804
5Nitrogen metabolism_Homo sapiens_hsa009102.94116208
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87260726
7Propanoate metabolism_Homo sapiens_hsa006402.85976616
8Sulfur relay system_Homo sapiens_hsa041222.84097466
9Glucagon signaling pathway_Homo sapiens_hsa049222.76040663
10Linoleic acid metabolism_Homo sapiens_hsa005912.71249309
11Basal transcription factors_Homo sapiens_hsa030222.68935569
12Fanconi anemia pathway_Homo sapiens_hsa034602.44981924
13Phototransduction_Homo sapiens_hsa047442.34539110
14Pentose phosphate pathway_Homo sapiens_hsa000302.27028390
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.16587560
16Glycerolipid metabolism_Homo sapiens_hsa005612.11494465
17Selenocompound metabolism_Homo sapiens_hsa004502.09273964
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.00459739
19Dorso-ventral axis formation_Homo sapiens_hsa043201.94114530
20Oxidative phosphorylation_Homo sapiens_hsa001901.93482360
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86516120
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82573189
23Antigen processing and presentation_Homo sapiens_hsa046121.81693261
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77828270
25PPAR signaling pathway_Homo sapiens_hsa033201.73553749
26RNA polymerase_Homo sapiens_hsa030201.73361657
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66094803
28Caffeine metabolism_Homo sapiens_hsa002321.64689803
29Allograft rejection_Homo sapiens_hsa053301.60173036
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.56719535
31Oocyte meiosis_Homo sapiens_hsa041141.55166716
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53803651
33Huntingtons disease_Homo sapiens_hsa050161.51483673
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48918821
35Autoimmune thyroid disease_Homo sapiens_hsa053201.47821968
36Graft-versus-host disease_Homo sapiens_hsa053321.46762952
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.46332476
38Butanoate metabolism_Homo sapiens_hsa006501.45951076
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39007920
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38938255
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37746581
42Fructose and mannose metabolism_Homo sapiens_hsa000511.37720894
43Type I diabetes mellitus_Homo sapiens_hsa049401.37392531
44Parkinsons disease_Homo sapiens_hsa050121.37180709
45Amphetamine addiction_Homo sapiens_hsa050311.37049664
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.35037619
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34610676
48Ether lipid metabolism_Homo sapiens_hsa005651.33682257
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33354205
50Nicotine addiction_Homo sapiens_hsa050331.33262371
51Tryptophan metabolism_Homo sapiens_hsa003801.29947324
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.29659259
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22689070
54mRNA surveillance pathway_Homo sapiens_hsa030151.21533494
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19140199
56Renin secretion_Homo sapiens_hsa049241.14545338
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.12720585
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11483238
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.11019543
60Olfactory transduction_Homo sapiens_hsa047401.10234899
61RNA transport_Homo sapiens_hsa030131.06793029
62Purine metabolism_Homo sapiens_hsa002301.02162453
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02153087
64Alzheimers disease_Homo sapiens_hsa050101.01584872
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01075373
66Mineral absorption_Homo sapiens_hsa049781.00400237
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98740936
68Retinol metabolism_Homo sapiens_hsa008300.98213150
69Protein export_Homo sapiens_hsa030600.96876928
70ABC transporters_Homo sapiens_hsa020100.88669570
71Carbon metabolism_Homo sapiens_hsa012000.86578315
72B cell receptor signaling pathway_Homo sapiens_hsa046620.86491250
73Regulation of autophagy_Homo sapiens_hsa041400.82574379
74Arachidonic acid metabolism_Homo sapiens_hsa005900.82551679
75Fat digestion and absorption_Homo sapiens_hsa049750.81667884
76Sulfur metabolism_Homo sapiens_hsa009200.80261973
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80164529
78Estrogen signaling pathway_Homo sapiens_hsa049150.79813395
79Renin-angiotensin system_Homo sapiens_hsa046140.79355987
80Inositol phosphate metabolism_Homo sapiens_hsa005620.78335341
81Collecting duct acid secretion_Homo sapiens_hsa049660.77367548
82Circadian rhythm_Homo sapiens_hsa047100.77183501
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75410398
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74983923
85Fatty acid metabolism_Homo sapiens_hsa012120.74139881
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70995500
87Cardiac muscle contraction_Homo sapiens_hsa042600.70781891
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70399250
89Fatty acid degradation_Homo sapiens_hsa000710.70212770
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70036923
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69217571
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69204421
93Hedgehog signaling pathway_Homo sapiens_hsa043400.65549207
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64185732
95beta-Alanine metabolism_Homo sapiens_hsa004100.63953099
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63740936
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62450830
98Legionellosis_Homo sapiens_hsa051340.61678636
99Peroxisome_Homo sapiens_hsa041460.61676712
100Morphine addiction_Homo sapiens_hsa050320.60772062
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.59153594
102Calcium signaling pathway_Homo sapiens_hsa040200.59058627
103Measles_Homo sapiens_hsa051620.58590441
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58376141
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55938055
106Ribosome_Homo sapiens_hsa030100.55810245
107Rheumatoid arthritis_Homo sapiens_hsa053230.55203328
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53244703
109Thyroid hormone synthesis_Homo sapiens_hsa049180.51152702
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51009978
111T cell receptor signaling pathway_Homo sapiens_hsa046600.50260777
112Homologous recombination_Homo sapiens_hsa034400.50244429
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49808956
114Biosynthesis of amino acids_Homo sapiens_hsa012300.49060293
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48109896
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46699161
117Long-term potentiation_Homo sapiens_hsa047200.46623045
118Viral myocarditis_Homo sapiens_hsa054160.45166672
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45135790
120Endocytosis_Homo sapiens_hsa041440.44407641
121RNA degradation_Homo sapiens_hsa030180.43985588
122Osteoclast differentiation_Homo sapiens_hsa043800.43408364
123Systemic lupus erythematosus_Homo sapiens_hsa053220.43126337
124Insulin secretion_Homo sapiens_hsa049110.42427059
125Influenza A_Homo sapiens_hsa051640.42165270
126Protein digestion and absorption_Homo sapiens_hsa049740.41120374
127Serotonergic synapse_Homo sapiens_hsa047260.39899078
128Primary immunodeficiency_Homo sapiens_hsa053400.39622655
129Tyrosine metabolism_Homo sapiens_hsa003500.39024554
130Hematopoietic cell lineage_Homo sapiens_hsa046400.38768412
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38748878
132Glutathione metabolism_Homo sapiens_hsa004800.37961044
133Asthma_Homo sapiens_hsa053100.37603479
134Chemical carcinogenesis_Homo sapiens_hsa052040.37359378
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37117853
136Pancreatic secretion_Homo sapiens_hsa049720.37015417
137Histidine metabolism_Homo sapiens_hsa003400.36389935
138Non-homologous end-joining_Homo sapiens_hsa034500.36370507
139Salmonella infection_Homo sapiens_hsa051320.35653757
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34350935
141cAMP signaling pathway_Homo sapiens_hsa040240.33993897
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.33879546
143Bile secretion_Homo sapiens_hsa049760.33819838
144Gastric acid secretion_Homo sapiens_hsa049710.33774300
145Toxoplasmosis_Homo sapiens_hsa051450.33649824
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31523639
147Proteasome_Homo sapiens_hsa030500.31425958
148Salivary secretion_Homo sapiens_hsa049700.31168677
149Ovarian steroidogenesis_Homo sapiens_hsa049130.30878593
150HIF-1 signaling pathway_Homo sapiens_hsa040660.30820115
151Taste transduction_Homo sapiens_hsa047420.29458256
152One carbon pool by folate_Homo sapiens_hsa006700.29257083
153Herpes simplex infection_Homo sapiens_hsa051680.29232973
154AMPK signaling pathway_Homo sapiens_hsa041520.28948406
155VEGF signaling pathway_Homo sapiens_hsa043700.28093702
156Viral carcinogenesis_Homo sapiens_hsa052030.28025727
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.26812066
158Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26722337
159Cell cycle_Homo sapiens_hsa041100.26231947
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23764419
161N-Glycan biosynthesis_Homo sapiens_hsa005100.23636824
162Metabolic pathways_Homo sapiens_hsa011000.23129058
163Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23020047

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