FBXW11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.40789861
2embryonic process involved in female pregnancy (GO:0060136)4.56514785
3negative regulation of JAK-STAT cascade (GO:0046426)4.46867730
4establishment of apical/basal cell polarity (GO:0035089)4.32029755
5signal complex assembly (GO:0007172)4.31092858
6establishment or maintenance of monopolar cell polarity (GO:0061339)4.24094737
7establishment of monopolar cell polarity (GO:0061162)4.24094737
8paraxial mesoderm development (GO:0048339)4.04437840
9cell migration in hindbrain (GO:0021535)3.98544772
10synaptic vesicle maturation (GO:0016188)3.93545494
11regulation of early endosome to late endosome transport (GO:2000641)3.87419901
12protein localization to endosome (GO:0036010)3.85892978
13regulation of cAMP-dependent protein kinase activity (GO:2000479)3.83374345
14locomotory exploration behavior (GO:0035641)3.82939043
15oxidative demethylation (GO:0070989)3.78897939
16positive regulation of protein homooligomerization (GO:0032464)3.75589428
17neuromuscular process controlling posture (GO:0050884)3.73130470
18cell communication by electrical coupling (GO:0010644)3.67583000
19regulation of protein homooligomerization (GO:0032462)3.67037698
20regulation of integrin activation (GO:0033623)3.66591287
21proline metabolic process (GO:0006560)3.59864366
22layer formation in cerebral cortex (GO:0021819)3.58697003
23synaptic vesicle endocytosis (GO:0048488)3.58666126
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57362065
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.54271653
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46312892
27positive regulation of dendritic spine morphogenesis (GO:0061003)3.42711436
28neuromuscular process controlling balance (GO:0050885)3.42174907
29negative regulation of protein oligomerization (GO:0032460)3.41750198
30mitotic G1 DNA damage checkpoint (GO:0031571)3.39766194
31synaptic vesicle exocytosis (GO:0016079)3.36281311
32cellular response to ATP (GO:0071318)3.31382425
33negative regulation of Ras GTPase activity (GO:0034261)3.27200003
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.20640291
35regulation of synaptic vesicle transport (GO:1902803)3.20063022
36mitochondrion transport along microtubule (GO:0047497)3.19558194
37establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.19558194
38regulation of NFAT protein import into nucleus (GO:0051532)3.18785284
39transcription from mitochondrial promoter (GO:0006390)3.18563131
40G1 DNA damage checkpoint (GO:0044783)3.18536477
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18309385
42amino acid import (GO:0043090)3.14741818
43sodium ion export (GO:0071436)3.14508639
44hypotonic response (GO:0006971)3.12244911
45cerebellar granule cell differentiation (GO:0021707)3.11804733
46nuclear pore complex assembly (GO:0051292)3.04124239
47COPI coating of Golgi vesicle (GO:0048205)3.01620220
48Golgi transport vesicle coating (GO:0048200)3.01620220
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01596981
50mitotic G1/S transition checkpoint (GO:0044819)3.00232202
51regulation of translational fidelity (GO:0006450)2.96196021
52glial cell migration (GO:0008347)2.95953996
53glutamate secretion (GO:0014047)2.94812470
54pre-miRNA processing (GO:0031054)2.90409074
55establishment of nucleus localization (GO:0040023)2.89549546
56regulation of respiratory system process (GO:0044065)2.87345749
57protein targeting to lysosome (GO:0006622)2.86622795
58establishment of protein localization to vacuole (GO:0072666)2.86622795
59protein targeting to vacuole (GO:0006623)2.86622795
60activation of Rac GTPase activity (GO:0032863)2.85905753
61N-glycan processing (GO:0006491)2.85464974
62neuronal ion channel clustering (GO:0045161)2.85282901
63dosage compensation (GO:0007549)2.84461267
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.83564235
65cellular protein complex localization (GO:0034629)2.83151021
66cellular potassium ion homeostasis (GO:0030007)2.82758278
67regulation of clathrin-mediated endocytosis (GO:2000369)2.82745994
68regulation of RNA export from nucleus (GO:0046831)2.81539338
69embryonic placenta development (GO:0001892)2.80729261
70replication fork processing (GO:0031297)2.79096047
71clathrin coat assembly (GO:0048268)2.76727532
72protein retention in ER lumen (GO:0006621)2.75407871
73neuron cell-cell adhesion (GO:0007158)2.74946639
74axonal fasciculation (GO:0007413)2.74098275
75adherens junction assembly (GO:0034333)2.73519571
76neuron recognition (GO:0008038)2.72758829
77regulation of nucleobase-containing compound transport (GO:0032239)2.72682289
78regulation of neuronal synaptic plasticity (GO:0048168)2.70583471
79dendrite morphogenesis (GO:0048813)2.69564832
80labyrinthine layer development (GO:0060711)2.69224784
81establishment of mitochondrion localization (GO:0051654)2.69148572
82axon extension (GO:0048675)2.68978044
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.68626977
84postsynaptic membrane organization (GO:0001941)2.67304029
85regulation of synaptic vesicle exocytosis (GO:2000300)2.66960514
86negative regulation of microtubule polymerization (GO:0031115)2.66939957
87regulation of protein oligomerization (GO:0032459)2.66877924
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66810106
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66658733
90mating behavior (GO:0007617)2.65831095
91stress fiber assembly (GO:0043149)2.65713476
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64801915
93exploration behavior (GO:0035640)2.64227499
94respiratory system process (GO:0003016)2.63850174
95convergent extension (GO:0060026)2.63468463
96neuromuscular process (GO:0050905)2.62281627
97dendritic spine morphogenesis (GO:0060997)2.60645065
98pyrimidine nucleobase catabolic process (GO:0006208)2.59726995
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.57604531
100nuclear pore organization (GO:0006999)2.55383268
101vesicle coating (GO:0006901)2.55037579
102nodal signaling pathway (GO:0038092)2.54994412
103regulation of dendritic spine morphogenesis (GO:0061001)2.54648837
104neurotransmitter secretion (GO:0007269)2.53222118
105focal adhesion assembly (GO:0048041)2.52672313
106cell-substrate adherens junction assembly (GO:0007045)2.52672313
107positive regulation of synapse maturation (GO:0090129)2.51870285
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.50971556
109regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.50907336
110negative regulation of chondrocyte differentiation (GO:0032331)2.50620684
111polarized epithelial cell differentiation (GO:0030859)2.49680221
112regulation of ARF GTPase activity (GO:0032312)2.49623283
113activation of protein kinase A activity (GO:0034199)2.49356137
114cell communication involved in cardiac conduction (GO:0086065)2.48308105
115neuron projection extension (GO:1990138)2.48162236
116positive regulation of lamellipodium assembly (GO:0010592)2.47959827
117protein localization to microtubule (GO:0035372)2.47744139
118protein complex localization (GO:0031503)2.47308786
119organelle transport along microtubule (GO:0072384)2.46332304
120regulation of synapse structural plasticity (GO:0051823)2.46196149
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.45594437
122apical protein localization (GO:0045176)2.45096998
123embryonic camera-type eye development (GO:0031076)2.44954075
124regulation of glomerular filtration (GO:0003093)2.44918136
125asymmetric protein localization (GO:0008105)2.44369206
126proline transport (GO:0015824)2.43851126
127negative regulation of GTPase activity (GO:0034260)2.42644067
128negative regulation of GTP catabolic process (GO:0033125)2.42644067
129vocalization behavior (GO:0071625)2.42004700
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41464629
131ectodermal placode formation (GO:0060788)2.40495621
132regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.40135827
133positive regulation of dendrite morphogenesis (GO:0050775)2.38677155
134mRNA cleavage (GO:0006379)2.37620487
135regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.37487344
136cellular response to prostaglandin stimulus (GO:0071379)2.36795272
137regulation of respiratory gaseous exchange (GO:0043576)2.36677799
138myelination in peripheral nervous system (GO:0022011)2.35572463
139peripheral nervous system axon ensheathment (GO:0032292)2.35572463
140synaptic vesicle docking involved in exocytosis (GO:0016081)2.35491513
141negative regulation of cell cycle arrest (GO:0071157)2.35154820
142developmental cell growth (GO:0048588)2.34624114
143L-amino acid import (GO:0043092)2.32991538
144negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.32162666
145cellular sodium ion homeostasis (GO:0006883)2.31796499
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29477235
147neurotransmitter-gated ion channel clustering (GO:0072578)2.27856441
148cytoplasmic mRNA processing body assembly (GO:0033962)2.27852246
149suckling behavior (GO:0001967)2.27701475
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.26586536
151pore complex assembly (GO:0046931)2.26440351
152regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.26329052
153regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.25644805
154positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.25644805
155dicarboxylic acid biosynthetic process (GO:0043650)2.24849593
156regulation of ARF protein signal transduction (GO:0032012)2.24037785
157protein localization to synapse (GO:0035418)2.23342418
158cell adhesion mediated by integrin (GO:0033627)2.22893114
159regulation of synaptic plasticity (GO:0048167)2.21897280
160regulation of glucose import in response to insulin stimulus (GO:2001273)2.21766309
161skin morphogenesis (GO:0043589)2.21086297
162positive regulation of dendritic spine development (GO:0060999)2.20986215
163neuromuscular junction development (GO:0007528)2.20802489
164hippo signaling (GO:0035329)2.20544491
165G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19738768
166presynaptic membrane assembly (GO:0097105)2.19457170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.30661130
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.29776733
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84963768
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.84733831
5* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.77401532
6CLOCK_20551151_ChIP-Seq_293T_Human2.73967395
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.63892963
8SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.57320987
9ZFP281_27345836_Chip-Seq_ESCs_Mouse2.39947364
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.32101655
11KDM2B_26808549_Chip-Seq_K562_Human2.27769600
12ZNF263_19887448_ChIP-Seq_K562_Human2.25193017
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25157208
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.15252006
15KDM2B_26808549_Chip-Seq_DND41_Human2.12648160
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.08024572
17LXR_22292898_ChIP-Seq_THP-1_Human2.04308196
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99791160
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98677103
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97713828
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.96760272
22P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75715443
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75554480
24EZH2_22144423_ChIP-Seq_EOC_Human1.72861540
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.72719671
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.67851882
27CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66069294
28RING1B_27294783_Chip-Seq_NPCs_Mouse1.64679364
29* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63610974
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63574399
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62728729
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58300603
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.55603804
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54808346
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54464723
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53293153
37RACK7_27058665_Chip-Seq_MCF-7_Human1.52820198
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52591631
39* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.52210737
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49782507
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49591893
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49303335
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49263360
44VDR_21846776_ChIP-Seq_THP-1_Human1.49209927
45* REST_18959480_ChIP-ChIP_MESCs_Mouse1.48379433
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.48346923
47* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48049958
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47236095
49* REST_21632747_ChIP-Seq_MESCs_Mouse1.46891956
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46708464
51DROSHA_22980978_ChIP-Seq_HELA_Human1.45583740
52* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44647050
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44230509
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.43970402
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.42408680
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.42150210
57AR_21909140_ChIP-Seq_LNCAP_Human1.41878665
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41105993
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39561825
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39248238
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.39106309
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.36988781
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36383789
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35230685
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34421195
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34235871
67* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.33367226
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33072985
69CREB1_26743006_Chip-Seq_LNCaP_Human1.32628606
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.31311248
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.31078490
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30988292
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30988292
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30007362
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29564515
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29564515
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29564515
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29111291
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28347544
80MYC_22102868_ChIP-Seq_BL_Human1.27108691
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26347015
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25747397
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25513987
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.23934872
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22949541
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22470534
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21863693
88TCF7_22412390_ChIP-Seq_EML_Mouse1.21726941
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20580887
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19093860
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18727835
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.18144347
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.17201123
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.16767840
95ZNF274_21170338_ChIP-Seq_K562_Hela1.14693524
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14352269
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14155510
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12860707
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12611239
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11322935
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10996116
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09660812
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09525232
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09126950
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08916949
106* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08911974
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08769544
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08556784
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08295167
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08108317
111AR_21572438_ChIP-Seq_LNCaP_Human1.07804889
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07803728
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07319814
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06631736
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06313335
116PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05605286
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05423331
118SOX9_26525672_Chip-Seq_HEART_Mouse1.05295510
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05221578
120* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05111606
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04740627
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04652608
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03623240
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02461370
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02447361
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02219543
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.01378192
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.01378192
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01152033
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01114053
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00895120
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00115930
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99560199
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.99480837
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99005925
136* CHD1_26751641_Chip-Seq_LNCaP_Human0.98793152
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97689706
138* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97251595
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97208459
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96419828
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96357874
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94963537
143TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94699459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.73051620
2MP0004233_abnormal_muscle_weight3.32558691
3MP0003283_abnormal_digestive_organ3.21373640
4MP0009278_abnormal_bone_marrow3.03202613
5MP0003941_abnormal_skin_development2.89399609
6MP0005171_absent_coat_pigmentation2.81951637
7MP0010030_abnormal_orbit_morphology2.58294683
8MP0003635_abnormal_synaptic_transmissio2.51817196
9MP0005076_abnormal_cell_differentiation2.34938771
10MP0002653_abnormal_ependyma_morphology2.34439990
11MP0002063_abnormal_learning/memory/cond2.30991335
12MP0000569_abnormal_digit_pigmentation2.28970319
13MP0004858_abnormal_nervous_system2.16071548
14MP0000778_abnormal_nervous_system1.95972694
15MP0004270_analgesia1.95089694
16MP0003890_abnormal_embryonic-extraembry1.92955835
17MP0009780_abnormal_chondrocyte_physiolo1.92773266
18MP0008057_abnormal_DNA_replication1.90390833
19MP0003705_abnormal_hypodermis_morpholog1.87787583
20MP0009046_muscle_twitch1.84357282
21MP0001348_abnormal_lacrimal_gland1.82412883
22MP0003172_abnormal_lysosome_physiology1.81425729
23MP0003119_abnormal_digestive_system1.78231553
24MP0002733_abnormal_thermal_nociception1.73599886
25MP0003566_abnormal_cell_adhesion1.72645355
26MP0002064_seizures1.71113542
27MP0002572_abnormal_emotion/affect_behav1.70357148
28MP0000955_abnormal_spinal_cord1.67453299
29MP0004811_abnormal_neuron_physiology1.67080853
30MP0010352_gastrointestinal_tract_polyps1.61844607
31MP0008961_abnormal_basal_metabolism1.61817206
32MP0005409_darkened_coat_color1.59894879
33MP0003122_maternal_imprinting1.59320126
34MP0002909_abnormal_adrenal_gland1.58085580
35MP0005623_abnormal_meninges_morphology1.48415653
36MP0002184_abnormal_innervation1.45164533
37MP0003045_fibrosis1.44966820
38MP0001188_hyperpigmentation1.43937482
39MP0002009_preneoplasia1.43691521
40MP0002282_abnormal_trachea_morphology1.42878320
41MP0008569_lethality_at_weaning1.39474272
42MP0006072_abnormal_retinal_apoptosis1.38468401
43MP0001970_abnormal_pain_threshold1.38406960
44MP0004272_abnormal_basement_membrane1.36686531
45MP0009672_abnormal_birth_weight1.36422171
46MP0005257_abnormal_intraocular_pressure1.36379698
47MP0001177_atelectasis1.35463575
48MP0009745_abnormal_behavioral_response1.34933907
49MP0005248_abnormal_Harderian_gland1.33567671
50MP0003880_abnormal_central_pattern1.33421588
51MP0004087_abnormal_muscle_fiber1.31642213
52MP0003690_abnormal_glial_cell1.30918117
53MP0008438_abnormal_cutaneous_collagen1.29847507
54MP0000579_abnormal_nail_morphology1.29445057
55MP0002697_abnormal_eye_size1.27588578
56MP0002084_abnormal_developmental_patter1.24357372
57MP0001984_abnormal_olfaction1.23613268
58MP0000537_abnormal_urethra_morphology1.23187489
59MP0010234_abnormal_vibrissa_follicle1.21921364
60MP0003091_abnormal_cell_migration1.20801533
61MP0003329_amyloid_beta_deposits1.20493280
62MP0001529_abnormal_vocalization1.19049113
63MP0003221_abnormal_cardiomyocyte_apopto1.18426133
64MP0004133_heterotaxia1.18393798
65MP0008995_early_reproductive_senescence1.18201073
66MP0000751_myopathy1.15589479
67MP0000759_abnormal_skeletal_muscle1.13394993
68MP0003633_abnormal_nervous_system1.12518348
69MP0001915_intracranial_hemorrhage1.11869709
70MP0002152_abnormal_brain_morphology1.11216886
71MP0000762_abnormal_tongue_morphology1.10613021
72MP0002877_abnormal_melanocyte_morpholog1.09688705
73MP0003634_abnormal_glial_cell1.07689385
74MP0004084_abnormal_cardiac_muscle1.07307098
75MP0003861_abnormal_nervous_system1.07163747
76MP0000428_abnormal_craniofacial_morphol1.06032190
77MP0004885_abnormal_endolymph1.05927703
78MP0002882_abnormal_neuron_morphology1.03221658
79MP0004185_abnormal_adipocyte_glucose1.03020971
80MP0001299_abnormal_eye_distance/1.01661941
81MP0001440_abnormal_grooming_behavior1.01411920
82MP0002066_abnormal_motor_capabilities/c1.01264020
83MP0004197_abnormal_fetal_growth/weight/1.01070801
84MP0002092_abnormal_eye_morphology0.99709725
85MP0002086_abnormal_extraembryonic_tissu0.99511178
86MP0010630_abnormal_cardiac_muscle0.98844386
87MP0002067_abnormal_sensory_capabilities0.98838710
88MP0003453_abnormal_keratinocyte_physiol0.98732721
89MP0005645_abnormal_hypothalamus_physiol0.98671333
90MP0002272_abnormal_nervous_system0.97422062
91MP0001730_embryonic_growth_arrest0.96931113
92MP0000920_abnormal_myelination0.96572620
93MP0004130_abnormal_muscle_cell0.95818071
94MP0002269_muscular_atrophy0.95005201
95MP0000003_abnormal_adipose_tissue0.94995093
96MP0004036_abnormal_muscle_relaxation0.94824480
97MP0000013_abnormal_adipose_tissue0.94748723
98MP0002081_perinatal_lethality0.94224132
99MP0005423_abnormal_somatic_nervous0.93667147
100MP0001968_abnormal_touch/_nociception0.93236108
101MP0005386_behavior/neurological_phenoty0.93019992
102MP0004924_abnormal_behavior0.93019992
103MP0002734_abnormal_mechanical_nocicepti0.92913603
104MP0000534_abnormal_ureter_morphology0.92622346
105MP0001486_abnormal_startle_reflex0.92138813
106MP0003137_abnormal_impulse_conducting0.91542319
107MP0003632_abnormal_nervous_system0.91462782
108MP0003075_altered_response_to0.91139560
109MP0002089_abnormal_postnatal_growth/wei0.91082967
110MP0000462_abnormal_digestive_system0.90695955
111MP0000749_muscle_degeneration0.90408585
112MP0000750_abnormal_muscle_regeneration0.90112341
113MP0000371_diluted_coat_color0.88577682
114MP0003115_abnormal_respiratory_system0.88343529
115MP0001340_abnormal_eyelid_morphology0.88010850
116MP0002796_impaired_skin_barrier0.87258837
117MP0003631_nervous_system_phenotype0.86975819
118MP0002085_abnormal_embryonic_tissue0.86427058
119MP0002735_abnormal_chemical_nociception0.86262318
120MP0001697_abnormal_embryo_size0.85602952
121MP0005187_abnormal_penis_morphology0.84936704
122MP0002557_abnormal_social/conspecific_i0.84793204
123MP0002896_abnormal_bone_mineralization0.83972707
124MP0001943_abnormal_respiration0.83401116
125MP0004145_abnormal_muscle_electrophysio0.82169582
126MP0009703_decreased_birth_body0.81763813
127MP0005451_abnormal_body_composition0.81120734
128MP0000604_amyloidosis0.80657325
129MP0002116_abnormal_craniofacial_bone0.80354726
130MP0001502_abnormal_circadian_rhythm0.79079562
131MP0005058_abnormal_lysosome_morphology0.78288031
132MP0003385_abnormal_body_wall0.77434675
133MP0002751_abnormal_autonomic_nervous0.77199435
134MP0005501_abnormal_skin_physiology0.76824030
135MP0001849_ear_inflammation0.76614163
136MP0005167_abnormal_blood-brain_barrier0.75257222
137MP0003123_paternal_imprinting0.74642144
138MP0000733_abnormal_muscle_development0.74530206
139MP0002822_catalepsy0.74184122
140MP0003942_abnormal_urinary_system0.73798387
141MP0005174_abnormal_tail_pigmentation0.73393686
142MP0004264_abnormal_extraembryonic_tissu0.72411042
143MP0003755_abnormal_palate_morphology0.72399698
144MP0001293_anophthalmia0.72205812
145MP0000747_muscle_weakness0.72190685

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.13350215
2Turricephaly (HP:0000262)3.58952023
3Myokymia (HP:0002411)3.47590441
4Concave nail (HP:0001598)3.41684864
5Orthostatic hypotension (HP:0001278)3.32220642
6Cerebral aneurysm (HP:0004944)3.12282677
7Visual hallucinations (HP:0002367)3.10866569
8Coronal craniosynostosis (HP:0004440)3.05599022
9Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.98039415
10Abnormality of the lower motor neuron (HP:0002366)2.89693745
11Facial hemangioma (HP:0000329)2.89169335
12Neurofibrillary tangles (HP:0002185)2.86484355
13Rib fusion (HP:0000902)2.84653844
14Insidious onset (HP:0003587)2.82351352
15Termporal pattern (HP:0011008)2.82351352
16Insomnia (HP:0100785)2.79643437
17Atonic seizures (HP:0010819)2.76628387
18Vertebral hypoplasia (HP:0008417)2.73677951
19Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.73677951
20Cortical dysplasia (HP:0002539)2.72974720
21Exercise-induced muscle cramps (HP:0003710)2.71753842
22Ulnar bowing (HP:0003031)2.66891436
23Action tremor (HP:0002345)2.66459602
24Focal seizures (HP:0007359)2.61022754
25Hypercortisolism (HP:0001578)2.58997637
26Lower limb amyotrophy (HP:0007210)2.57853698
27Alacrima (HP:0000522)2.57072065
28Anteriorly placed anus (HP:0001545)2.55171471
29Hammertoe (HP:0001765)2.54968684
30Mucopolysacchariduria (HP:0008155)2.53432162
31Urinary glycosaminoglycan excretion (HP:0003541)2.53432162
32Papillary thyroid carcinoma (HP:0002895)2.50034530
33Aplasia involving bones of the extremities (HP:0009825)2.42419513
34Aplasia involving bones of the upper limbs (HP:0009823)2.42419513
35Aplasia of the phalanges of the hand (HP:0009802)2.42419513
36Abnormality of polysaccharide metabolism (HP:0011012)2.35232778
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35232778
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35232778
39Narrow nasal bridge (HP:0000446)2.33014470
40Spastic gait (HP:0002064)2.31148539
41Abnormality of the astrocytes (HP:0100707)2.30558985
42Astrocytoma (HP:0009592)2.30558985
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.26909681
44Focal motor seizures (HP:0011153)2.26546156
45Shallow orbits (HP:0000586)2.26375234
46Congenital hip dislocation (HP:0001374)2.24323529
47Scanning speech (HP:0002168)2.23417429
48Increased IgM level (HP:0003496)2.23391704
49Clumsiness (HP:0002312)2.20118104
50Protrusio acetabuli (HP:0003179)2.19510391
51Absence seizures (HP:0002121)2.17068403
52Male infertility (HP:0003251)2.14358406
53Supranuclear gaze palsy (HP:0000605)2.12594324
54Vertebral arch anomaly (HP:0008438)2.11990799
55Overriding aorta (HP:0002623)2.11406324
56Growth hormone excess (HP:0000845)2.10073278
57Spinal muscular atrophy (HP:0007269)2.08838496
58Distal lower limb amyotrophy (HP:0008944)2.08546083
59Hand muscle atrophy (HP:0009130)2.08209895
60Dysostosis multiplex (HP:0000943)2.07169528
61Ankyloglossia (HP:0010296)2.06673437
62Premature rupture of membranes (HP:0001788)2.06231589
63Renovascular hypertension (HP:0100817)2.05878312
64Arnold-Chiari malformation (HP:0002308)2.03388315
65Dysautonomia (HP:0002459)2.02868269
66Dysdiadochokinesis (HP:0002075)2.02813307
67Subaortic stenosis (HP:0001682)2.02606430
68Abnormality of the left ventricular outflow tract (HP:0011103)2.02606430
69Peripheral hypomyelination (HP:0007182)2.02282368
70Short humerus (HP:0005792)2.01396575
71Spastic diplegia (HP:0001264)2.01043116
72Macroorchidism (HP:0000053)2.00600082
73Epileptic encephalopathy (HP:0200134)2.00165191
74Failure to thrive in infancy (HP:0001531)1.99573208
75Short chin (HP:0000331)1.99553083
76Distal upper limb amyotrophy (HP:0007149)1.99152884
77Upper limb amyotrophy (HP:0009129)1.99152884
78Cubitus valgus (HP:0002967)1.97156679
79Lower limb muscle weakness (HP:0007340)1.96701685
80Truncal ataxia (HP:0002078)1.96562649
81Obstructive sleep apnea (HP:0002870)1.96543110
82Drooling (HP:0002307)1.95717203
83Congenital glaucoma (HP:0001087)1.94413665
84Decreased lacrimation (HP:0000633)1.92868968
85Abnormality of the labia minora (HP:0012880)1.92834685
86Asymmetry of the thorax (HP:0001555)1.91733067
87Difficulty running (HP:0009046)1.91530098
88Ankle clonus (HP:0011448)1.91083994
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90530357
90Increased CSF protein (HP:0002922)1.89732284
91Alopecia of scalp (HP:0002293)1.89405795
92Intention tremor (HP:0002080)1.89312264
93Hyporeflexia of lower limbs (HP:0002600)1.89161894
94Progressive sensorineural hearing impairment (HP:0000408)1.88528508
95Elfin facies (HP:0004428)1.88435478
96Scapular winging (HP:0003691)1.88258127
97Bundle branch block (HP:0011710)1.87155942
98Aqueductal stenosis (HP:0002410)1.86894635
99Poikiloderma (HP:0001029)1.86808951
100Dialeptic seizures (HP:0011146)1.85422602
101Progressive cerebellar ataxia (HP:0002073)1.83752369
102Decreased motor nerve conduction velocity (HP:0003431)1.83669554
103Spinal cord lesions (HP:0100561)1.83564717
104Syringomyelia (HP:0003396)1.83564717
105Rectovaginal fistula (HP:0000143)1.83077182
106Rectal fistula (HP:0100590)1.83077182
107Arterial tortuosity (HP:0005116)1.81404023
108Urinary bladder sphincter dysfunction (HP:0002839)1.78580001
109Abnormality of the corticospinal tract (HP:0002492)1.78171524
110Spinal rigidity (HP:0003306)1.77876325
111Pointed chin (HP:0000307)1.77694349
112Impaired smooth pursuit (HP:0007772)1.77406361
113Depression (HP:0000716)1.77092294
114Abnormality of the aortic arch (HP:0012303)1.76943144
115Broad alveolar ridges (HP:0000187)1.76479356
116Neoplasm of the heart (HP:0100544)1.76269088
117Febrile seizures (HP:0002373)1.75923125
118Back pain (HP:0003418)1.75670824
119Volvulus (HP:0002580)1.75650782
120Hamartoma (HP:0010566)1.75559433
121Papilledema (HP:0001085)1.75424434
122Abnormality of the musculature of the pelvis (HP:0001469)1.75340509
123Abnormality of the hip-girdle musculature (HP:0001445)1.75340509
124Abnormality of the periventricular white matter (HP:0002518)1.75214286
125Type 1 muscle fiber predominance (HP:0003803)1.74795376
126Shoulder girdle muscle weakness (HP:0003547)1.74605197
127Excessive salivation (HP:0003781)1.72834248
128Increased variability in muscle fiber diameter (HP:0003557)1.72757007
129Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72237045
130Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.71947821
131Relative macrocephaly (HP:0004482)1.71876095
132Abnormality of skeletal muscle fiber size (HP:0012084)1.71716203
133Tongue fasciculations (HP:0001308)1.71675603
134Overgrowth (HP:0001548)1.71213988
135Muscle fibrillation (HP:0010546)1.69359020
136Apathy (HP:0000741)1.69143010
137Foot dorsiflexor weakness (HP:0009027)1.68415833
138Aplasia/hypoplasia of the humerus (HP:0006507)1.68232609
139Muscle fiber inclusion bodies (HP:0100299)1.67885382
140Bladder diverticulum (HP:0000015)1.67696260
141Vascular tortuosity (HP:0004948)1.67531911
142Asymmetric septal hypertrophy (HP:0001670)1.66810019
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66067305
144Dysmetria (HP:0001310)1.65666327
145Urinary urgency (HP:0000012)1.65653575
146Limb-girdle muscle weakness (HP:0003325)1.65445827
147Selective tooth agenesis (HP:0001592)1.65050599
148Abnormality of the foot musculature (HP:0001436)1.64856836
149Exercise-induced myalgia (HP:0003738)1.64848310
150Intestinal fistula (HP:0100819)1.64552841
151Impaired vibration sensation in the lower limbs (HP:0002166)1.64505793
152Choanal stenosis (HP:0000452)1.64496349
153Limb-girdle muscle atrophy (HP:0003797)1.64351524
154Bowing of the arm (HP:0006488)1.63713259
155Bowed forearm bones (HP:0003956)1.63713259
156Distal sensory impairment (HP:0002936)1.63326354
157Cerebral inclusion bodies (HP:0100314)1.63307591
158Vaginal fistula (HP:0004320)1.63037861
159Bronchomalacia (HP:0002780)1.63036861
160Atrophic scars (HP:0001075)1.62697228
161Genetic anticipation (HP:0003743)1.62591942
162Nemaline bodies (HP:0003798)1.62413078
163Clonus (HP:0002169)1.62186215
164Joint stiffness (HP:0001387)1.61881965
165Hyperextensible skin (HP:0000974)1.61383921
166Pheochromocytoma (HP:0002666)1.61346242
167Pelvic girdle muscle weakness (HP:0003749)1.61340878
168Megalencephaly (HP:0001355)1.60747934
169Mitral regurgitation (HP:0001653)1.60415627
170Split hand (HP:0001171)1.59840397
171Bowel diverticulosis (HP:0005222)1.59777260
172Hepatoblastoma (HP:0002884)1.59507578
173Diminished motivation (HP:0000745)1.59116844
174Dysmetric saccades (HP:0000641)1.59035418
175Menstrual irregularities (HP:0000858)1.58980203
176Hyperacusis (HP:0010780)1.58805166
177Curly hair (HP:0002212)1.58610181
178Broad thumb (HP:0011304)1.58318552
179Increased number of teeth (HP:0011069)1.57549985
180Achilles tendon contracture (HP:0001771)1.57390394
181Heterotopia (HP:0002282)1.57172368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.10984908
2ICK4.09038443
3TYRO33.67298350
4MAP3K93.36424557
5MAP3K63.01978110
6PDGFRA2.70389162
7MAPK152.52057087
8UHMK12.44700231
9MAP3K112.30233462
10MATK2.16471954
11DAPK12.13885296
12ARAF2.12436697
13TRIB32.11719230
14FGR2.07703162
15BMX1.93265556
16LATS21.87798926
17EEF2K1.87633162
18PINK11.74627324
19NTRK31.73213336
20MINK11.72152914
21TTN1.71049984
22KSR11.70166065
23PAK61.64929900
24NTRK21.60114013
25MAP2K71.58902616
26DYRK1B1.53282630
27RIPK11.52607626
28MARK11.49256899
29KSR21.46401701
30MAP3K41.44098520
31CASK1.42433195
32PHKG21.31435245
33PHKG11.31435245
34PRKD21.30085119
35PRKD31.27547588
36MAP3K131.24298331
37MOS1.23736990
38NTRK11.22335037
39CSK1.17763083
40SGK2231.16456413
41SGK4941.16456413
42CDC42BPA1.13840987
43ERBB31.11598940
44CAMK1G1.10991929
45SGK31.09308605
46BRAF1.08184011
47SRPK11.02242695
48TESK11.01009403
49BRD41.00835631
50SCYL20.99357569
51MAP3K100.97088943
52NEK90.96898701
53ALK0.94414382
54PTK20.93815445
55SGK20.93775224
56RET0.92425275
57EPHA40.89480427
58OBSCN0.87888315
59CAMKK10.86695465
60DMPK0.86342413
61SIK30.85626414
62SIK10.83936744
63MET0.83245917
64PDGFRB0.83210243
65CDK50.83154870
66CAMK1D0.81752105
67HIPK20.81703353
68FGFR20.78261826
69DAPK20.77746641
70FGFR10.73955027
71GSK3A0.73857677
72YES10.73089440
73ERBB40.72783857
74SIK20.72369169
75CDK60.72065047
76MTOR0.72052219
77TRPM70.71713587
78FER0.70796085
79STK380.69350144
80LIMK10.68191414
81NEK60.67500781
82RAF10.66881252
83PTK60.65534692
84MAP2K40.65527732
85LMTK20.64668844
86MAP3K20.63552531
87PAK30.62888733
88TAOK10.62846789
89ROCK20.60897205
90DYRK30.60756555
91CSNK1A1L0.59693695
92CDK180.59629278
93CDK140.59626289
94PRKAA10.59221367
95EPHA30.58942941
96RPS6KA10.57675155
97PBK0.57565471
98PKN20.57151895
99MAPK100.56899310
100CAMK2G0.56253304
101CDK150.55745117
102CDK120.55455992
103AKT20.54740628
104BCR0.54552802
105CSNK1G20.53825444
106AKT30.53268485
107WNK30.52917767
108STK38L0.52636119
109CAMK40.52587999
110NEK10.51555281
111RPS6KA20.49531768
112SGK10.49159754
113EGFR0.48525028
114EPHB10.46724512
115DYRK1A0.46504039
116CDK11A0.46448431
117CDK190.44594449
118WNK10.43892884
119STK110.42670085
120RPS6KA40.42363482
121PIM20.42331770
122EPHA20.41955952
123PRKCZ0.40848409
124PRKCH0.40670273
125RPS6KL10.40434688
126RPS6KC10.40434688
127EPHB20.40306870
128CAMKK20.38433885
129MAP3K50.38415369
130MAPK110.38131997
131DYRK20.37934590
132RPS6KA30.37318636
133FGFR40.35849761
134CAMK2B0.34860051
135RPS6KB10.34541630
136PRPF4B0.34383780
137CAMK2A0.33979677
138MAP3K10.32278110
139CDK70.31674646
140LATS10.31597060
141MARK20.31284935
142PAK40.30997104
143PAK20.30594722
144PRKD10.28589437

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.52068613
2mTOR signaling pathway_Homo sapiens_hsa041502.08602951
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81573957
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70796201
5Long-term potentiation_Homo sapiens_hsa047201.69414865
6VEGF signaling pathway_Homo sapiens_hsa043701.59483395
7Gap junction_Homo sapiens_hsa045401.57045506
8* Hippo signaling pathway_Homo sapiens_hsa043901.56286999
9Synaptic vesicle cycle_Homo sapiens_hsa047211.53629094
10Nicotine addiction_Homo sapiens_hsa050331.53027208
11ErbB signaling pathway_Homo sapiens_hsa040121.52503303
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51417031
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45592269
14GABAergic synapse_Homo sapiens_hsa047271.42779043
15Glioma_Homo sapiens_hsa052141.41665443
16Dopaminergic synapse_Homo sapiens_hsa047281.40551328
17Notch signaling pathway_Homo sapiens_hsa043301.40413061
18Dilated cardiomyopathy_Homo sapiens_hsa054141.40354665
19Dorso-ventral axis formation_Homo sapiens_hsa043201.38293299
20Amphetamine addiction_Homo sapiens_hsa050311.37546757
21Adherens junction_Homo sapiens_hsa045201.36683024
22Estrogen signaling pathway_Homo sapiens_hsa049151.35951876
23Long-term depression_Homo sapiens_hsa047301.31028161
24Glutamatergic synapse_Homo sapiens_hsa047241.30204410
25GnRH signaling pathway_Homo sapiens_hsa049121.29453158
26Colorectal cancer_Homo sapiens_hsa052101.29288815
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28573091
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28396501
29Circadian entrainment_Homo sapiens_hsa047131.26145117
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24914738
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24035274
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22727472
33Endometrial cancer_Homo sapiens_hsa052131.22613891
34Choline metabolism in cancer_Homo sapiens_hsa052311.19492118
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.18497047
36Chronic myeloid leukemia_Homo sapiens_hsa052201.17628136
37Prion diseases_Homo sapiens_hsa050201.15816042
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12603400
39Olfactory transduction_Homo sapiens_hsa047401.12403244
40Oxytocin signaling pathway_Homo sapiens_hsa049211.12217292
41Proteoglycans in cancer_Homo sapiens_hsa052051.11793807
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10351965
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09693442
44Gastric acid secretion_Homo sapiens_hsa049711.09500011
45* Oocyte meiosis_Homo sapiens_hsa041141.09147033
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09011629
47Cholinergic synapse_Homo sapiens_hsa047251.07338980
48* Hedgehog signaling pathway_Homo sapiens_hsa043401.06798216
49Insulin secretion_Homo sapiens_hsa049111.06691404
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06448008
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05980879
52Melanogenesis_Homo sapiens_hsa049161.04775236
53Morphine addiction_Homo sapiens_hsa050321.03673432
54Type II diabetes mellitus_Homo sapiens_hsa049301.03332754
55* Wnt signaling pathway_Homo sapiens_hsa043101.02920858
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02899947
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02102473
58Vibrio cholerae infection_Homo sapiens_hsa051101.02015282
59Axon guidance_Homo sapiens_hsa043601.01617786
60Bladder cancer_Homo sapiens_hsa052191.00635081
61Basal cell carcinoma_Homo sapiens_hsa052171.00249687
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99476902
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98373041
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98159734
65Salivary secretion_Homo sapiens_hsa049700.97806933
66MAPK signaling pathway_Homo sapiens_hsa040100.96096085
67Cocaine addiction_Homo sapiens_hsa050300.94084707
68Endocytosis_Homo sapiens_hsa041440.93935067
69Insulin signaling pathway_Homo sapiens_hsa049100.93072836
70Alcoholism_Homo sapiens_hsa050340.90799198
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89914405
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89485241
73Renal cell carcinoma_Homo sapiens_hsa052110.89269891
74Biosynthesis of amino acids_Homo sapiens_hsa012300.87794401
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87767513
76ECM-receptor interaction_Homo sapiens_hsa045120.87677651
77Focal adhesion_Homo sapiens_hsa045100.87409005
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87254506
79Non-small cell lung cancer_Homo sapiens_hsa052230.87109480
80Inositol phosphate metabolism_Homo sapiens_hsa005620.85617830
81Renin secretion_Homo sapiens_hsa049240.85531306
82Tight junction_Homo sapiens_hsa045300.85504984
83MicroRNAs in cancer_Homo sapiens_hsa052060.84821142
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.84765100
85TGF-beta signaling pathway_Homo sapiens_hsa043500.84442696
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84187359
87Melanoma_Homo sapiens_hsa052180.83784530
88mRNA surveillance pathway_Homo sapiens_hsa030150.82924221
89AMPK signaling pathway_Homo sapiens_hsa041520.80632668
90Prolactin signaling pathway_Homo sapiens_hsa049170.80181335
91Prostate cancer_Homo sapiens_hsa052150.79466357
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78426970
93* Shigellosis_Homo sapiens_hsa051310.78293560
94Rap1 signaling pathway_Homo sapiens_hsa040150.76930620
95Pancreatic cancer_Homo sapiens_hsa052120.76628292
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.76468077
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.76236223
98Viral myocarditis_Homo sapiens_hsa054160.75664964
99cAMP signaling pathway_Homo sapiens_hsa040240.73704467
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72801097
101* Circadian rhythm_Homo sapiens_hsa047100.72159712
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72098464
103Small cell lung cancer_Homo sapiens_hsa052220.71608578
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70871455
105Nitrogen metabolism_Homo sapiens_hsa009100.70607531
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69815767
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69385159
108Vitamin B6 metabolism_Homo sapiens_hsa007500.68346917
109Thyroid cancer_Homo sapiens_hsa052160.65369656
110Arginine biosynthesis_Homo sapiens_hsa002200.64433704
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61028029
112Ras signaling pathway_Homo sapiens_hsa040140.57686348
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57645412
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57287139
115Thyroid hormone synthesis_Homo sapiens_hsa049180.56230536
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55622916
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55557527
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54571967
119Taste transduction_Homo sapiens_hsa047420.54357615
120Glucagon signaling pathway_Homo sapiens_hsa049220.52861678
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52734247

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