ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	imidazole-containing compound metabolic process (GO:0052803)	8.89935504
2	urate metabolic process (GO:0046415)	5.80681142
3	drug catabolic process (GO:0042737)	5.67421545
4	angiotensin maturation (GO:0002003)	5.42479024
5	cellular biogenic amine biosynthetic process (GO:0042401)	4.95947649
6	fatty acid elongation (GO:0030497)	4.76209287
7	replication fork processing (GO:0031297)	4.75265129
8	amine biosynthetic process (GO:0009309)	4.71458232
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.67885497
10	L-phenylalanine catabolic process (GO:0006559)	4.67885497
11	artery smooth muscle contraction (GO:0014824)	4.42903526
12	cellular response to leptin stimulus (GO:0044320)	4.33788447
13	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.20623527
14	L-phenylalanine metabolic process (GO:0006558)	4.12836994
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.12836994
16	DNA strand renaturation (GO:0000733)	4.03323359
17	reverse cholesterol transport (GO:0043691)	3.97934142
18	tonic smooth muscle contraction (GO:0014820)	3.91558904
19	renal absorption (GO:0070293)	3.86271575
20	complement activation, alternative pathway (GO:0006957)	3.78957753
21	cullin deneddylation (GO:0010388)	3.76863001
22	short-chain fatty acid metabolic process (GO:0046459)	3.73036286
23	positive regulation of mast cell degranulation (GO:0043306)	3.72661399
24	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.72661399
25	branched-chain amino acid catabolic process (GO:0009083)	3.63180925
26	exogenous drug catabolic process (GO:0042738)	3.59598960
27	catechol-containing compound biosynthetic process (GO:0009713)	3.58515191
28	catecholamine biosynthetic process (GO:0042423)	3.58515191
29	drug metabolic process (GO:0017144)	3.55083074
30	glyoxylate metabolic process (GO:0046487)	3.54201217
31	regulation of protein activation cascade (GO:2000257)	3.53719039
32	retinal cone cell development (GO:0046549)	3.49221994
33	protein deneddylation (GO:0000338)	3.45121671
34	peptide hormone processing (GO:0016486)	3.44928459
35	response to leptin (GO:0044321)	3.44065573
36	regulation of complement activation (GO:0030449)	3.42927995
37	blood coagulation, intrinsic pathway (GO:0007597)	3.41046208
38	arginine catabolic process (GO:0006527)	3.36820661
39	regulation of T cell cytokine production (GO:0002724)	3.36272326
40	signal peptide processing (GO:0006465)	3.35961435
41	peroxisome fission (GO:0016559)	3.34600959
42	arginine metabolic process (GO:0006525)	3.33133078
43	cytokine biosynthetic process (GO:0042089)	3.32882944
44	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.30872443
45	response to mercury ion (GO:0046689)	3.27755257
46	xenobiotic catabolic process (GO:0042178)	3.26639353
47	bile acid biosynthetic process (GO:0006699)	3.24769389
48	coenzyme catabolic process (GO:0009109)	3.22597139
49	glutamine family amino acid biosynthetic process (GO:0009084)	3.21881356
50	alpha-amino acid catabolic process (GO:1901606)	3.15582538
51	endosome to melanosome transport (GO:0035646)	3.15039765
52	endosome to pigment granule transport (GO:0043485)	3.15039765
53	branched-chain amino acid metabolic process (GO:0009081)	3.12955903
54	organic cation transport (GO:0015695)	3.07889561
55	positive regulation of p38MAPK cascade (GO:1900745)	3.07454492
56	aromatic amino acid family catabolic process (GO:0009074)	3.04638811
57	response to misfolded protein (GO:0051788)	3.04166851
58	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.00126111
59	alpha-linolenic acid metabolic process (GO:0036109)	2.99404526
60	omega-hydroxylase P450 pathway (GO:0097267)	2.95078400
61	response to nitrosative stress (GO:0051409)	2.94995775
62	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	2.94242059
63	epoxygenase P450 pathway (GO:0019373)	2.93193063
64	negative regulation of protein activation cascade (GO:2000258)	2.91844694
65	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.91661185
66	regulation of T cell tolerance induction (GO:0002664)	2.91535915
67	negative regulation of fibrinolysis (GO:0051918)	2.90383646
68	sequestering of actin monomers (GO:0042989)	2.89050845
69	urea metabolic process (GO:0019627)	2.88512690
70	tyrosine metabolic process (GO:0006570)	2.88381760
71	bile acid metabolic process (GO:0008206)	2.88184250
72	flavonoid metabolic process (GO:0009812)	2.87666666
73	protein carboxylation (GO:0018214)	2.86810940
74	peptidyl-glutamic acid carboxylation (GO:0017187)	2.86810940
75	cellular amino acid catabolic process (GO:0009063)	2.86158833
76	cellular zinc ion homeostasis (GO:0006882)	2.84958973
77	tricarboxylic acid cycle (GO:0006099)	2.84233605
78	positive regulation of prostaglandin secretion (GO:0032308)	2.83502196
79	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.82643439
80	regulation of voltage-gated calcium channel activity (GO:1901385)	2.81077849
81	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.79588136
82	acyl-CoA biosynthetic process (GO:0071616)	2.78724924
83	thioester biosynthetic process (GO:0035384)	2.78724924
84	regulation of fibrinolysis (GO:0051917)	2.76878698
85	regulation of relaxation of muscle (GO:1901077)	2.75844099
86	branch elongation of an epithelium (GO:0060602)	2.72252761
87	regulation of prostaglandin secretion (GO:0032306)	2.70782218
88	vascular smooth muscle contraction (GO:0014829)	2.69710523
89	positive regulation of icosanoid secretion (GO:0032305)	2.69174785
90	lipopolysaccharide biosynthetic process (GO:0009103)	2.67814558
91	positive regulation of fatty acid transport (GO:2000193)	2.67498617
92	positive regulation of mast cell activation (GO:0033005)	2.66410223
93	intestinal cholesterol absorption (GO:0030299)	2.66296527
94	regulation of p38MAPK cascade (GO:1900744)	2.64598753
95	positive regulation of leukocyte degranulation (GO:0043302)	2.64479532
96	polyamine biosynthetic process (GO:0006596)	2.64410615
97	regulation of cardiac muscle cell contraction (GO:0086004)	2.62561843
98	detection of light stimulus involved in sensory perception (GO:0050962)	2.62167009
99	detection of light stimulus involved in visual perception (GO:0050908)	2.62167009
100	cofactor catabolic process (GO:0051187)	2.61827384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.08741196
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	5.83845599
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.85156202
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.23101275
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.04817587
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.95547321
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.39666724
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.25119611
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.19576532
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.19498776
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.13747948
12	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.11486259
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.08873990
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01214531
15	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.93247512
16	VDR_22108803_ChIP-Seq_LS180_Human	1.92670091
17	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.86372137
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.86112455
19	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.85134131
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.79617546
21	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.75539920
22	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.69250935
23	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.63101440
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.62530276
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.61470839
26	STAT3_23295773_ChIP-Seq_U87_Human	1.61303296
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50928518
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.50022633
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47556225
30	ZNF263_19887448_ChIP-Seq_K562_Human	1.37969527
31	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.37921079
32	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.34133963
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33620426
34	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.31694398
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31240103
36	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27110616
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26338020
38	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25532331
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.25219243
40	AR_20517297_ChIP-Seq_VCAP_Human	1.25217202
41	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.24402445
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23380436
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22867903
44	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.22827138
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20653253
46	TCF4_23295773_ChIP-Seq_U87_Human	1.20412256
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.19937765
48	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.16130566
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15792669
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.10378218
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10222629
52	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.09941492
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.09243227
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07167618
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06802815
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06710010
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06710010
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.06620899
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03010591
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.02752150
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02423311
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.02050539
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02050539
64	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.02001613
65	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.99045870
66	TCF4_22108803_ChIP-Seq_LS180_Human	0.98606823
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98093713
68	NCOR_22424771_ChIP-Seq_293T_Human	0.97318701
69	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.96595731
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96147055
71	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.95659667
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93369349
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.91267151
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90498461
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90433294
76	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.89084338
77	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.88255722
78	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.87347815
79	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.86337519
80	P300_19829295_ChIP-Seq_ESCs_Human	0.85896639
81	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84728324
82	FUS_26573619_Chip-Seq_HEK293_Human	0.83974264
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.83921524
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.83448345
85	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.83108366
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82783737
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.82497174
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.81798843
89	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.81070675
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.80851414
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80409926
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80409926
93	EOMES_21245162_ChIP-Seq_HESCs_Human	0.79258580
94	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.79223332
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.78327163
96	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.78185937
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.78159158
98	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.77926984
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.77592877
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.77288273

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.31834409
2	MP0002139_abnormal_hepatobiliary_system	3.08984896
3	MP0001661_extended_life_span	3.07775099
4	MP0005085_abnormal_gallbladder_physiolo	3.00341842
5	MP0008260_abnormal_autophagy	2.93848353
6	MP0002735_abnormal_chemical_nociception	2.91407581
7	MP0003195_calcinosis	2.87008391
8	MP0009697_abnormal_copulation	2.68957242
9	MP0010368_abnormal_lymphatic_system	2.67871297
10	MP0005360_urolithiasis	2.63535072
11	MP0005332_abnormal_amino_acid	2.47951032
12	MP0004043_abnormal_pH_regulation	2.32691621
13	MP0003329_amyloid_beta_deposits	2.29502379
14	MP0006054_spinal_hemorrhage	2.23882468
15	MP0003656_abnormal_erythrocyte_physiolo	2.22278819
16	MP0002822_catalepsy	2.20142641
17	MP0000579_abnormal_nail_morphology	2.18626525
18	MP0005365_abnormal_bile_salt	2.11742533
19	MP0000647_abnormal_sebaceous_gland	2.11472725
20	MP0003252_abnormal_bile_duct	2.07680939
21	MP0005551_abnormal_eye_electrophysiolog	2.06928872
22	MP0001853_heart_inflammation	2.06056071
23	MP0010329_abnormal_lipoprotein_level	2.05694882
24	MP0000383_abnormal_hair_follicle	1.88859131
25	MP0001984_abnormal_olfaction	1.85843003
26	MP0005410_abnormal_fertilization	1.82718097
27	MP0005275_abnormal_skin_tensile	1.81662072
28	MP0002734_abnormal_mechanical_nocicepti	1.78011621
29	MP0003950_abnormal_plasma_membrane	1.75350164
30	MP0009643_abnormal_urine_homeostasis	1.61254166
31	MP0000604_amyloidosis	1.58792769
32	MP0005464_abnormal_platelet_physiology	1.54989507
33	MP0002638_abnormal_pupillary_reflex	1.52212271
34	MP0006276_abnormal_autonomic_nervous	1.48175713
35	MP0001529_abnormal_vocalization	1.45277627
36	MP0005503_abnormal_tendon_morphology	1.43400820
37	MP0009840_abnormal_foam_cell	1.40784055
38	MP0002736_abnormal_nociception_after	1.38430870
39	MP0000427_abnormal_hair_cycle	1.37849395
40	MP0000751_myopathy	1.37606636
41	MP0002136_abnormal_kidney_physiology	1.36639126
42	MP0001756_abnormal_urination	1.36246975
43	MP0005171_absent_coat_pigmentation	1.34297953
44	MP0004147_increased_porphyrin_level	1.33573565
45	MP0001986_abnormal_taste_sensitivity	1.31462870
46	MP0005636_abnormal_mineral_homeostasis	1.29155400
47	MP0005670_abnormal_white_adipose	1.27401510
48	MP0002971_abnormal_brown_adipose	1.26852172
49	MP0001666_abnormal_nutrient_absorption	1.24674945
50	MP0001764_abnormal_homeostasis	1.24364591
51	MP0005083_abnormal_biliary_tract	1.23173318
52	MP0004019_abnormal_vitamin_homeostasis	1.22134976
53	MP0003186_abnormal_redox_activity	1.18856907
54	MP0005253_abnormal_eye_physiology	1.18050946
55	MP0001968_abnormal_touch/_nociception	1.16455128
56	MP0005075_abnormal_melanosome_morpholog	1.12725173
57	MP0002970_abnormal_white_adipose	1.09582002
58	MP0009115_abnormal_fat_cell	1.05259505
59	MP0002132_abnormal_respiratory_system	1.03576972
60	MP0010678_abnormal_skin_adnexa	1.01136340
61	MP0003191_abnormal_cellular_cholesterol	1.01008376
62	MP0005448_abnormal_energy_balance	1.00570005
63	MP0005319_abnormal_enzyme/_coenzyme	0.99778992
64	MP0003011_delayed_dark_adaptation	0.98805133
65	MP0002295_abnormal_pulmonary_circulatio	0.96226454
66	MP0002118_abnormal_lipid_homeostasis	0.95529867
67	MP0003879_abnormal_hair_cell	0.95055554
68	MP0003638_abnormal_response/metabolism_	0.93652522
69	MP0002876_abnormal_thyroid_physiology	0.91112538
70	MP0008872_abnormal_physiological_respon	0.90873923
71	MP0001915_intracranial_hemorrhage	0.90568707
72	MP0009780_abnormal_chondrocyte_physiolo	0.90414282
73	MP0003787_abnormal_imprinting	0.90245559
74	MP0002160_abnormal_reproductive_system	0.88393120
75	MP0000609_abnormal_liver_physiology	0.87215548
76	MP0003786_premature_aging	0.86246101
77	MP0006072_abnormal_retinal_apoptosis	0.80987468
78	MP0008877_abnormal_DNA_methylation	0.79529990
79	MP0000749_muscle_degeneration	0.78707366
80	MP0001502_abnormal_circadian_rhythm	0.78119664
81	MP0002733_abnormal_thermal_nociception	0.77789162
82	MP0009642_abnormal_blood_homeostasis	0.77384961
83	MP0004233_abnormal_muscle_weight	0.75816800
84	MP0000747_muscle_weakness	0.74576348
85	MP0000598_abnormal_liver_morphology	0.74368545
86	MP0001324_abnormal_eye_pigmentation	0.73874083
87	MP0005408_hypopigmentation	0.72839918
88	MP0002572_abnormal_emotion/affect_behav	0.71951354
89	MP0005187_abnormal_penis_morphology	0.70559134
90	MP0002653_abnormal_ependyma_morphology	0.67715251
91	MP0003953_abnormal_hormone_level	0.66810428
92	MP0008995_early_reproductive_senescence	0.64942160
93	MP0009046_muscle_twitch	0.64905394
94	MP0005389_reproductive_system_phenotype	0.64698982
95	MP0005197_abnormal_uvea_morphology	0.64358579
96	MP0003646_muscle_fatigue	0.63869947
97	MP0009765_abnormal_xenobiotic_induced	0.63482576
98	MP0003183_abnormal_peptide_metabolism	0.63333614
99	MP0004883_abnormal_blood_vessel	0.62479358
100	MP0003806_abnormal_nucleotide_metabolis	0.62462042

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Follicular hyperkeratosis (HP:0007502)	5.06892750
2	Brittle hair (HP:0002299)	4.43963425
3	Pili torti (HP:0003777)	4.07570688
4	Hyperlipoproteinemia (HP:0010980)	4.07411463
5	Renal Fanconi syndrome (HP:0001994)	3.83753813
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.79819020
7	Thyroid-stimulating hormone excess (HP:0002925)	3.51311280
8	Congenital, generalized hypertrichosis (HP:0004540)	3.50805006
9	Complement deficiency (HP:0004431)	3.43772340
10	Abnormal hair laboratory examination (HP:0003328)	3.40469277
11	Generalized aminoaciduria (HP:0002909)	3.35451603
12	Deep venous thrombosis (HP:0002625)	3.23835498
13	Hypoalphalipoproteinemia (HP:0003233)	3.21786001
14	Prolonged neonatal jaundice (HP:0006579)	3.11199567
15	Intrahepatic cholestasis (HP:0001406)	3.10304378
16	Spastic tetraparesis (HP:0001285)	3.01668613
17	Hypophosphatemic rickets (HP:0004912)	2.89887462
18	Decreased circulating renin level (HP:0003351)	2.89538600
19	Tubulointerstitial nephritis (HP:0001970)	2.87508948
20	Increased circulating renin level (HP:0000848)	2.85610738
21	Prolonged partial thromboplastin time (HP:0003645)	2.85413330
22	Abnormality of methionine metabolism (HP:0010901)	2.85381422
23	Glycosuria (HP:0003076)	2.84062925
24	Abnormality of urine glucose concentration (HP:0011016)	2.84062925
25	Conjugated hyperbilirubinemia (HP:0002908)	2.83051134
26	Insidious onset (HP:0003587)	2.74828035
27	Termporal pattern (HP:0011008)	2.74828035
28	Recurrent corneal erosions (HP:0000495)	2.73529215
29	Type I transferrin isoform profile (HP:0003642)	2.69273525
30	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.68948095
31	Action tremor (HP:0002345)	2.68896351
32	Hypolipoproteinemia (HP:0010981)	2.67294248
33	Hyperactive renin-angiotensin system (HP:0000841)	2.51773564
34	Xanthomatosis (HP:0000991)	2.49151631
35	Glomerulosclerosis (HP:0000096)	2.49047856
36	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.49025517
37	Disproportionate short-trunk short stature (HP:0003521)	2.42931922
38	Abnormality of complement system (HP:0005339)	2.38565452
39	Hypobetalipoproteinemia (HP:0003563)	2.37083302
40	Hyponatremia (HP:0002902)	2.33975031
41	Male infertility (HP:0003251)	2.33880797
42	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.33748853
43	Increased hepatocellular lipid droplets (HP:0006565)	2.31709963
44	Albinism (HP:0001022)	2.30992666
45	Lipid accumulation in hepatocytes (HP:0006561)	2.24026185
46	Hypothermia (HP:0002045)	2.22736526
47	Impaired proprioception (HP:0010831)	2.18841419
48	Respiratory difficulties (HP:0002880)	2.18774977
49	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.17268269
50	Sensorimotor neuropathy (HP:0007141)	2.17126815
51	Hyperaldosteronism (HP:0000859)	2.13652500
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.13446563
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.13446563
54	Hypokinesia (HP:0002375)	2.12479098
55	Metabolic acidosis (HP:0001942)	2.11823710
56	Autoamputation (HP:0001218)	2.11276743
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10683388
58	Nonimmune hydrops fetalis (HP:0001790)	2.10639153
59	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.09276888
60	Neonatal respiratory distress (HP:0002643)	2.07812140
61	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.06394178
62	Abnormality of renal resorption (HP:0011038)	2.06168229
63	Methylmalonic acidemia (HP:0002912)	2.00870949
64	Abnormal drinking behavior (HP:0030082)	1.99419834
65	Polydipsia (HP:0001959)	1.99419834
66	Arthropathy (HP:0003040)	1.95077879
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94986102
68	Woolly hair (HP:0002224)	1.94603828
69	Abnormality of macular pigmentation (HP:0008002)	1.94587922
70	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94394964
71	Joint hemorrhage (HP:0005261)	1.90697773
72	Focal segmental glomerulosclerosis (HP:0000097)	1.89597610
73	Optic neuritis (HP:0100653)	1.89374246
74	Retrobulbar optic neuritis (HP:0100654)	1.89374246
75	Systemic lupus erythematosus (HP:0002725)	1.89261510
76	Facial diplegia (HP:0001349)	1.88474106
77	Acute hepatic failure (HP:0006554)	1.85998284
78	Toxemia of pregnancy (HP:0100603)	1.85000457
79	Proximal tubulopathy (HP:0000114)	1.84944313
80	Abnormality of renin-angiotensin system (HP:0000847)	1.84764144
81	Polyuria (HP:0000103)	1.80482705
82	Hypokalemic alkalosis (HP:0001949)	1.79621798
83	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.79116840
84	Fat malabsorption (HP:0002630)	1.79068150
85	Atonic seizures (HP:0010819)	1.78242770
86	Abnormality of lateral ventricle (HP:0030047)	1.78220019
87	Episodic fever (HP:0001954)	1.77435218
88	Hyperkalemia (HP:0002153)	1.77086214
89	Tubulointerstitial abnormality (HP:0001969)	1.76664991
90	Abnormality of sodium homeostasis (HP:0010931)	1.75813192
91	Neurodegeneration (HP:0002180)	1.74584654
92	Orthostatic hypotension (HP:0001278)	1.72866981
93	Abnormal urine output (HP:0012590)	1.72160394
94	Paralysis (HP:0003470)	1.72038661
95	Abnormality of the periventricular white matter (HP:0002518)	1.71563627
96	Abnormality of potassium homeostasis (HP:0011042)	1.71024303
97	Renal tubular dysfunction (HP:0000124)	1.70848154
98	Alkalosis (HP:0001948)	1.69023151
99	Orchitis (HP:0100796)	1.68665705
100	Short tibia (HP:0005736)	1.68519788

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.89146865
2	NEK6	3.02071027
3	BCKDK	2.97356179
4	EPHA3	2.35221003
5	PDK2	13.5125544
6	MAP4K2	1.62578417
7	NTRK2	1.60401598
8	PBK	1.60308162
9	BMPR1B	1.33259545
10	TNIK	1.29759286
11	FER	1.18461854
12	KDR	1.15115186
13	MET	1.04121335
14	CDK8	1.03039641
15	PIK3CA	1.00601726
16	ERBB4	0.99819826
17	TXK	0.99154098
18	FES	0.97348765
19	MAP2K6	0.93244487
20	CSF1R	0.92431290
21	STK38	0.91772346
22	MAPK7	0.89949045
23	PIK3CG	0.89605830
24	STK16	0.88735400
25	SIK3	0.86046248
26	TAOK3	0.84284801
27	AKT3	0.84140739
28	PTK2B	0.82927559
29	ERBB3	0.79019553
30	PDPK1	0.77256692
31	STK39	0.75796461
32	MAPK12	0.75602555
33	FRK	0.74716880
34	PDK1	0.74318787
35	WNK4	0.73577261
36	MYLK	0.72829632
37	DYRK1A	0.69221446
38	BMX	0.59935241
39	INSRR	0.57429026
40	MAP2K2	0.56689496
41	PLK2	0.56674038
42	FGR	0.55676616
43	SIK2	0.54691769
44	PKN2	0.54544572
45	MAP2K1	0.53002612
46	BCR	0.50146020
47	MARK1	0.49694586
48	IRAK3	0.49424005
49	ADRBK2	0.49027863
50	PRKD2	0.48631026
51	GRK1	0.47383534
52	PRKCE	0.47378039
53	PINK1	0.46867903
54	SIK1	0.45870988
55	PIM2	0.40883384
56	PRKACG	0.40542182
57	SRPK1	0.40492798
58	NEK1	0.40245122
59	CAMKK2	0.40148693
60	OXSR1	0.38995211
61	MAP3K2	0.38797997
62	LIMK1	0.36672874
63	ZAK	0.35801211
64	MAP3K12	0.33091679
65	PRKACA	0.32459239
66	KSR1	0.31932781
67	PRKCG	0.31334000
68	MST4	0.31145091
69	KSR2	0.30656901
70	PAK6	0.30257760
71	IKBKE	0.30205131
72	PRKCZ	0.29088951
73	MAPK13	0.28055834
74	MARK3	0.27797458
75	MUSK	0.26584573
76	CAMK2B	0.24609591
77	MKNK2	0.22880286
78	EPHA2	0.22695826
79	PTK2	0.21981977
80	PRKCA	0.21758157
81	DYRK3	0.21606031
82	RET	0.21599686
83	SRC	0.21592996
84	INSR	0.20855950
85	MAP3K4	0.20550737
86	AKT2	0.20371520
87	EGFR	0.20033602
88	TBK1	0.19058565
89	ADRBK1	0.18242659
90	TAOK1	0.17613547
91	CAMK2A	0.17561892
92	PRKCI	0.16920169
93	ICK	0.16728099
94	JAK1	0.16171385
95	MAPK1	0.16057789
96	DAPK2	0.14542395
97	CAMK2D	0.13925429
98	IGF1R	0.13097304
99	TESK1	0.12518967
100	LCK	0.12401507

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.31961036
2	Renin-angiotensin system_Homo sapiens_hsa04614	3.30388505
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.95343733
4	Fatty acid metabolism_Homo sapiens_hsa01212	2.66394384
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.66289941
6	Histidine metabolism_Homo sapiens_hsa00340	2.63448617
7	Fatty acid elongation_Homo sapiens_hsa00062	2.59728567
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.47288285
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.44018231
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.41907994
11	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.40398632
12	Complement and coagulation cascades_Homo sapiens_hsa04610	2.39804831
13	Peroxisome_Homo sapiens_hsa04146	2.28774573
14	Propanoate metabolism_Homo sapiens_hsa00640	2.24415433
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.14922816
16	Butanoate metabolism_Homo sapiens_hsa00650	2.01581496
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.97917172
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.95889879
19	Caffeine metabolism_Homo sapiens_hsa00232	1.94910064
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.90266783
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.89922969
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.89712592
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87934468
24	ABC transporters_Homo sapiens_hsa02010	1.77024705
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.74343393
26	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.68455109
27	Retinol metabolism_Homo sapiens_hsa00830	1.68133239
28	Fatty acid degradation_Homo sapiens_hsa00071	1.66545322
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.60760805
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.45890345
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.38373516
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.36883510
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.36246596
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.36157747
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.34913930
36	Carbon metabolism_Homo sapiens_hsa01200	1.33938472
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25667659
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.24438595
39	Other glycan degradation_Homo sapiens_hsa00511	1.21291053
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.21258595
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.14209985
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.13777486
43	PPAR signaling pathway_Homo sapiens_hsa03320	1.12587052
44	Sulfur metabolism_Homo sapiens_hsa00920	1.09090710
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03009539
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02597668
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98857583
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98350625
49	Asthma_Homo sapiens_hsa05310	0.97675131
50	Glutathione metabolism_Homo sapiens_hsa00480	0.97294631
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.95523808
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.94019031
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93464995
54	Proteasome_Homo sapiens_hsa03050	0.93455921
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92733698
56	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.90674367
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89723511
58	Bile secretion_Homo sapiens_hsa04976	0.88930217
59	Olfactory transduction_Homo sapiens_hsa04740	0.83487692
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76980509
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70430484
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69167639
63	Metabolic pathways_Homo sapiens_hsa01100	0.66946700
64	One carbon pool by folate_Homo sapiens_hsa00670	0.64639097
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62006109
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60570479
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60198555
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57093483
69	Homologous recombination_Homo sapiens_hsa03440	0.54280316
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.54107795
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.50057833
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47433411
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.44228292
74	Regulation of autophagy_Homo sapiens_hsa04140	0.43145855
75	Lysosome_Homo sapiens_hsa04142	0.42742868
76	Oxidative phosphorylation_Homo sapiens_hsa00190	0.42201854
77	Phototransduction_Homo sapiens_hsa04744	0.36824129
78	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.35875988
79	RNA polymerase_Homo sapiens_hsa03020	0.33078340
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31873250
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28513155
82	Protein export_Homo sapiens_hsa03060	0.28387838
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.26851992
84	Galactose metabolism_Homo sapiens_hsa00052	0.24439180
85	Taste transduction_Homo sapiens_hsa04742	0.23496642
86	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.23378310
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21550220
88	Alzheimers disease_Homo sapiens_hsa05010	0.19136997
89	Lysine degradation_Homo sapiens_hsa00310	0.18947596
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.18656546
91	Insulin secretion_Homo sapiens_hsa04911	0.17724736
92	Circadian rhythm_Homo sapiens_hsa04710	0.15998497
93	Morphine addiction_Homo sapiens_hsa05032	0.15800267
94	Purine metabolism_Homo sapiens_hsa00230	0.15594898
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.15168377
96	Parkinsons disease_Homo sapiens_hsa05012	0.14201620
97	Huntingtons disease_Homo sapiens_hsa05016	0.12137268
98	Oocyte meiosis_Homo sapiens_hsa04114	0.10960696
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.10840209
100	Pancreatic secretion_Homo sapiens_hsa04972	0.10255362

FBXW11P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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