FBXW12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)5.90927256
2piRNA metabolic process (GO:0034587)5.41055033
3regulation of acrosome reaction (GO:0060046)5.22357056
4regulation of female gonad development (GO:2000194)5.05969092
5retinal cone cell development (GO:0046549)4.69736485
6DNA methylation involved in gamete generation (GO:0043046)4.60589472
7regulation of meiosis I (GO:0060631)4.54446733
8behavioral response to nicotine (GO:0035095)4.26749587
9meiotic cell cycle (GO:0051321)4.00094178
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94536962
11L-fucose catabolic process (GO:0042355)3.81906884
12fucose catabolic process (GO:0019317)3.81906884
13L-fucose metabolic process (GO:0042354)3.81906884
14response to pheromone (GO:0019236)3.78246668
15reproduction (GO:0000003)3.73029952
16protein polyglutamylation (GO:0018095)3.50288453
17regulation of DNA methylation (GO:0044030)3.49369168
18centriole replication (GO:0007099)3.48572221
19epithelial cilium movement (GO:0003351)3.40298874
20protein K11-linked deubiquitination (GO:0035871)3.38611976
21detection of light stimulus involved in sensory perception (GO:0050962)3.35783786
22detection of light stimulus involved in visual perception (GO:0050908)3.35783786
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34849341
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.34397838
25pyrimidine nucleobase catabolic process (GO:0006208)3.24102837
26synapsis (GO:0007129)3.21796059
27water-soluble vitamin biosynthetic process (GO:0042364)3.19782591
28DNA deamination (GO:0045006)3.19725129
29female gamete generation (GO:0007292)3.13254584
30cilium or flagellum-dependent cell motility (GO:0001539)3.12910943
31gene silencing by RNA (GO:0031047)3.05560153
32sperm-egg recognition (GO:0035036)3.04392489
33replication fork processing (GO:0031297)3.03318582
34negative regulation of transcription regulatory region DNA binding (GO:2000678)3.00647044
35regulation of calcium ion-dependent exocytosis (GO:0017158)2.98575438
36sperm motility (GO:0030317)2.96779658
37male meiosis I (GO:0007141)2.94762133
38male meiosis (GO:0007140)2.94409858
39tachykinin receptor signaling pathway (GO:0007217)2.92308159
40axoneme assembly (GO:0035082)2.91956668
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91266639
42positive regulation of gastrulation (GO:2000543)2.90633835
43indolalkylamine metabolic process (GO:0006586)2.89272445
44glycine transport (GO:0015816)2.88853942
45regulation of nuclear cell cycle DNA replication (GO:0033262)2.86847751
46gamma-aminobutyric acid transport (GO:0015812)2.85600359
47cilium movement (GO:0003341)2.84969434
48single fertilization (GO:0007338)2.84401260
49nucleobase catabolic process (GO:0046113)2.80657814
50DNA double-strand break processing (GO:0000729)2.80046299
51oocyte development (GO:0048599)2.78863290
52nonmotile primary cilium assembly (GO:0035058)2.78348748
53fertilization (GO:0009566)2.78070714
54meiotic chromosome segregation (GO:0045132)2.74906669
55negative regulation of mast cell activation (GO:0033004)2.72704512
56cellular ketone body metabolic process (GO:0046950)2.70470397
57inositol phosphate catabolic process (GO:0071545)2.70431156
58photoreceptor cell development (GO:0042461)2.70326291
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69651825
60regulation of mitotic spindle checkpoint (GO:1903504)2.69651825
61neural tube formation (GO:0001841)2.66531671
62reciprocal meiotic recombination (GO:0007131)2.66387585
63reciprocal DNA recombination (GO:0035825)2.66387585
64positive regulation of meiosis (GO:0045836)2.63027780
65indole-containing compound catabolic process (GO:0042436)2.62804842
66indolalkylamine catabolic process (GO:0046218)2.62804842
67tryptophan catabolic process (GO:0006569)2.62804842
68recombinational repair (GO:0000725)2.62753133
69double-strand break repair via homologous recombination (GO:0000724)2.60430927
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.59317217
71behavioral response to ethanol (GO:0048149)2.58769137
72cilium morphogenesis (GO:0060271)2.57757640
73cAMP catabolic process (GO:0006198)2.57537198
74DNA alkylation (GO:0006305)2.55282601
75DNA methylation (GO:0006306)2.55282601
76photoreceptor cell maintenance (GO:0045494)2.54953382
77protein K6-linked ubiquitination (GO:0085020)2.54614772
78acrosome reaction (GO:0007340)2.53845799
79cell-cell recognition (GO:0009988)2.53350436
80somite rostral/caudal axis specification (GO:0032525)2.53171145
81cilium organization (GO:0044782)2.52307262
82kynurenine metabolic process (GO:0070189)2.52119728
83negative regulation of cAMP-mediated signaling (GO:0043951)2.51041326
84cornea development in camera-type eye (GO:0061303)2.51008736
85negative regulation of telomere maintenance (GO:0032205)2.50927656
86negative regulation of reproductive process (GO:2000242)2.50361343
87mannosylation (GO:0097502)2.50088593
88inositol phosphate dephosphorylation (GO:0046855)2.49618811
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49618811
90DNA methylation or demethylation (GO:0044728)2.48768059
91rhodopsin mediated signaling pathway (GO:0016056)2.48350908
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47870381
93cilium assembly (GO:0042384)2.46497785
94platelet dense granule organization (GO:0060155)2.46497714
95positive regulation of meiotic cell cycle (GO:0051446)2.45387931
96DNA modification (GO:0006304)2.45104682
97ketone body metabolic process (GO:1902224)2.45013707
98meiosis I (GO:0007127)2.44806827
99eye photoreceptor cell development (GO:0042462)2.44058389
100regulation of action potential (GO:0098900)2.43615558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34461242
2ZNF274_21170338_ChIP-Seq_K562_Hela3.56212586
3GBX2_23144817_ChIP-Seq_PC3_Human3.09746405
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82258178
5VDR_22108803_ChIP-Seq_LS180_Human2.76092192
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61039150
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34318559
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28414642
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14380790
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13010234
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12196163
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04104729
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02599834
14IGF1R_20145208_ChIP-Seq_DFB_Human1.99768867
15P300_19829295_ChIP-Seq_ESCs_Human1.97088455
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97069187
17EWS_26573619_Chip-Seq_HEK293_Human1.94167328
18TAF15_26573619_Chip-Seq_HEK293_Human1.84481784
19FUS_26573619_Chip-Seq_HEK293_Human1.79623292
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76993435
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74741737
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.74608160
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72441163
24CBP_20019798_ChIP-Seq_JUKART_Human1.72441163
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.70198594
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.70034569
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69519914
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67825719
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66348082
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65385977
31ER_23166858_ChIP-Seq_MCF-7_Human1.65111341
32IRF1_19129219_ChIP-ChIP_H3396_Human1.64706662
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61470317
34STAT3_23295773_ChIP-Seq_U87_Human1.58071122
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57610087
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57610087
37TCF4_23295773_ChIP-Seq_U87_Human1.56407484
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55521957
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53932868
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.53709793
41TP53_22573176_ChIP-Seq_HFKS_Human1.52902921
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52130273
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51677675
44AR_25329375_ChIP-Seq_VCAP_Human1.50602221
45BCAT_22108803_ChIP-Seq_LS180_Human1.46210060
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43061983
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42802932
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41517198
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.41176666
50REST_21632747_ChIP-Seq_MESCs_Mouse1.38219329
51RUNX2_22187159_ChIP-Seq_PCA_Human1.37368669
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37130719
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35955831
54* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32666206
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.31452286
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.30851778
57SOX2_19829295_ChIP-Seq_ESCs_Human1.28879658
58NANOG_19829295_ChIP-Seq_ESCs_Human1.28879658
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26985178
60* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26208272
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.24619829
62TCF4_22108803_ChIP-Seq_LS180_Human1.24276089
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24015921
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22481474
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22436517
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20608191
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.20501801
68MYC_18940864_ChIP-ChIP_HL60_Human1.20369459
69RNF2_27304074_Chip-Seq_NSC_Mouse1.20321921
70NCOR_22424771_ChIP-Seq_293T_Human1.19588149
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18046085
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.18046085
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17676434
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17186547
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14894238
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.13904935
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12705228
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08913040
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08042851
80AR_21572438_ChIP-Seq_LNCaP_Human1.07016906
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06996539
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.06291084
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05854225
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05322803
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.05225073
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.04329630
87AR_20517297_ChIP-Seq_VCAP_Human1.03788991
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.02884110
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.02250339
90HOXB7_26014856_ChIP-Seq_BT474_Human1.00443169
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99769818
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.98452388
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98316686
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97766861
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.96916239
96CDX2_22108803_ChIP-Seq_LS180_Human0.95858561
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94746585
98NANOG_20526341_ChIP-Seq_ESCs_Human0.94717220
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94128267
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93136947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect3.93646302
2MP0008877_abnormal_DNA_methylation3.90415315
3MP0006292_abnormal_olfactory_placode3.72961709
4MP0002102_abnormal_ear_morphology2.80878324
5MP0008789_abnormal_olfactory_epithelium2.53094540
6MP0005551_abnormal_eye_electrophysiolog2.51211268
7MP0003195_calcinosis2.25703971
8MP0003787_abnormal_imprinting2.13435315
9MP0005499_abnormal_olfactory_system2.10701091
10MP0005394_taste/olfaction_phenotype2.10701091
11MP0001986_abnormal_taste_sensitivity1.92844882
12MP0005646_abnormal_pituitary_gland1.86635817
13MP0005410_abnormal_fertilization1.85551639
14MP0001968_abnormal_touch/_nociception1.83653284
15MP0006276_abnormal_autonomic_nervous1.82474502
16MP0003880_abnormal_central_pattern1.80103866
17MP0002638_abnormal_pupillary_reflex1.79157644
18MP0003136_yellow_coat_color1.78619274
19MP0002138_abnormal_hepatobiliary_system1.77631627
20MP0003646_muscle_fatigue1.77394071
21MP0002234_abnormal_pharynx_morphology1.74263812
22MP0000569_abnormal_digit_pigmentation1.73545567
23MP0004142_abnormal_muscle_tone1.72147572
24MP0002272_abnormal_nervous_system1.72025966
25MP0001984_abnormal_olfaction1.69623343
26MP0006072_abnormal_retinal_apoptosis1.68113693
27MP0003890_abnormal_embryonic-extraembry1.67416787
28MP0005253_abnormal_eye_physiology1.64658475
29MP0009745_abnormal_behavioral_response1.63539718
30MP0000372_irregular_coat_pigmentation1.62646542
31MP0004043_abnormal_pH_regulation1.62466482
32MP0001929_abnormal_gametogenesis1.61950765
33MP0002735_abnormal_chemical_nociception1.57807354
34MP0003121_genomic_imprinting1.57533496
35MP0001486_abnormal_startle_reflex1.53868739
36MP0000427_abnormal_hair_cycle1.53244772
37MP0005395_other_phenotype1.51682957
38MP0000631_abnormal_neuroendocrine_gland1.51286867
39MP0001501_abnormal_sleep_pattern1.50310139
40MP0005389_reproductive_system_phenotype1.47362241
41MP0008058_abnormal_DNA_repair1.45754326
42MP0002653_abnormal_ependyma_morphology1.44370973
43MP0002210_abnormal_sex_determination1.42870065
44MP0002736_abnormal_nociception_after1.40416449
45MP0008872_abnormal_physiological_respon1.39276231
46MP0001919_abnormal_reproductive_system1.38782864
47MP0009046_muscle_twitch1.36339465
48MP0004885_abnormal_endolymph1.35435967
49MP0008875_abnormal_xenobiotic_pharmacok1.35067287
50MP0002160_abnormal_reproductive_system1.33144629
51MP0001485_abnormal_pinna_reflex1.32129565
52MP0002837_dystrophic_cardiac_calcinosis1.29551924
53MP0003698_abnormal_male_reproductive1.28704875
54MP0005645_abnormal_hypothalamus_physiol1.27141277
55MP0002572_abnormal_emotion/affect_behav1.22257581
56MP0000653_abnormal_sex_gland1.21657833
57MP0002876_abnormal_thyroid_physiology1.19550995
58MP0001293_anophthalmia1.13092276
59MP0008995_early_reproductive_senescence1.12447044
60MP0004742_abnormal_vestibular_system1.10678636
61MP0002557_abnormal_social/conspecific_i1.10163025
62MP0005174_abnormal_tail_pigmentation1.08646781
63MP0002928_abnormal_bile_duct1.07891634
64MP0003878_abnormal_ear_physiology1.06479362
65MP0005377_hearing/vestibular/ear_phenot1.06479362
66MP0004133_heterotaxia1.05505072
67MP0003635_abnormal_synaptic_transmissio1.03386135
68MP0004147_increased_porphyrin_level1.00941797
69MP0001963_abnormal_hearing_physiology1.00397877
70MP0001764_abnormal_homeostasis1.00356303
71MP0001145_abnormal_male_reproductive1.00030295
72MP0002063_abnormal_learning/memory/cond0.99669245
73MP0002067_abnormal_sensory_capabilities0.98984419
74MP0005195_abnormal_posterior_eye0.97365463
75MP0000778_abnormal_nervous_system0.97343620
76MP0001119_abnormal_female_reproductive0.96564036
77MP0002229_neurodegeneration0.94424416
78MP0002161_abnormal_fertility/fecundity0.94172536
79MP0003950_abnormal_plasma_membrane0.93457766
80MP0001529_abnormal_vocalization0.93069110
81MP0008775_abnormal_heart_ventricle0.91757731
82MP0003119_abnormal_digestive_system0.91395118
83MP0002064_seizures0.91316121
84MP0003699_abnormal_female_reproductive0.91233860
85MP0005360_urolithiasis0.91049754
86MP0002938_white_spotting0.90229863
87MP0002752_abnormal_somatic_nervous0.88174809
88MP0002095_abnormal_skin_pigmentation0.88134970
89MP0001970_abnormal_pain_threshold0.87755537
90MP0001324_abnormal_eye_pigmentation0.87553944
91MP0001502_abnormal_circadian_rhythm0.87359156
92MP0003252_abnormal_bile_duct0.87235552
93MP0000026_abnormal_inner_ear0.86741501
94MP0002751_abnormal_autonomic_nervous0.85226351
95MP0002733_abnormal_thermal_nociception0.84399952
96MP0010094_abnormal_chromosome_stability0.83684349
97MP0004924_abnormal_behavior0.83342775
98MP0005386_behavior/neurological_phenoty0.83342775
99MP0000049_abnormal_middle_ear0.83320175
100MP0003879_abnormal_hair_cell0.82290109

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.12746670
2Abnormality of midbrain morphology (HP:0002418)4.07552098
3Molar tooth sign on MRI (HP:0002419)4.07552098
4Pancreatic fibrosis (HP:0100732)3.82909695
5True hermaphroditism (HP:0010459)3.59904850
6Hyperventilation (HP:0002883)3.49242878
7Nephronophthisis (HP:0000090)3.46921219
8Supernumerary spleens (HP:0009799)3.33443289
9Chronic hepatic failure (HP:0100626)3.32121022
10Congenital stationary night blindness (HP:0007642)3.28243701
11Type II lissencephaly (HP:0007260)3.16352380
12Hypoplasia of the fovea (HP:0007750)3.07635227
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.07635227
14Abnormality of the renal medulla (HP:0100957)3.07581236
15Attenuation of retinal blood vessels (HP:0007843)2.91856358
16Medial flaring of the eyebrow (HP:0010747)2.83359292
17Gaze-evoked nystagmus (HP:0000640)2.82649250
18Abnormality of the renal cortex (HP:0011035)2.79890624
19Abnormal biliary tract physiology (HP:0012439)2.74423521
20Bile duct proliferation (HP:0001408)2.74423521
21Cystic liver disease (HP:0006706)2.56377720
22Pendular nystagmus (HP:0012043)2.55916945
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.54571381
24Oligodactyly (hands) (HP:0001180)2.53429928
25Abnormality of the fovea (HP:0000493)2.48935475
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.47632752
27Fair hair (HP:0002286)2.46819173
28Tubular atrophy (HP:0000092)2.46301136
29Optic nerve hypoplasia (HP:0000609)2.38913988
30Anterior segment dysgenesis (HP:0007700)2.36794937
31Abnormality of the labia minora (HP:0012880)2.35243258
32Abnormal rod and cone electroretinograms (HP:0008323)2.33288933
33Gait imbalance (HP:0002141)2.32626127
34Cerebellar dysplasia (HP:0007033)2.32087685
35Broad-based gait (HP:0002136)2.31019123
36Abnormal drinking behavior (HP:0030082)2.26524314
37Polydipsia (HP:0001959)2.26524314
38Bony spicule pigmentary retinopathy (HP:0007737)2.25817494
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.24787521
40Sclerocornea (HP:0000647)2.24259804
41Anencephaly (HP:0002323)2.23205477
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23092760
43Congenital primary aphakia (HP:0007707)2.22851265
44Absent/shortened dynein arms (HP:0200106)2.21729504
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.21729504
46Retinal dysplasia (HP:0007973)2.19838504
47Decreased circulating renin level (HP:0003351)2.17985946
48Stomach cancer (HP:0012126)2.17693553
49Impulsivity (HP:0100710)2.16830523
50Progressive inability to walk (HP:0002505)2.15983182
51Decreased central vision (HP:0007663)2.12883354
52Methylmalonic aciduria (HP:0012120)2.09424328
53Methylmalonic acidemia (HP:0002912)2.09301742
54Congenital hepatic fibrosis (HP:0002612)2.08797258
55Febrile seizures (HP:0002373)2.07558153
56Chromsome breakage (HP:0040012)2.07243174
57Abnormality of the ileum (HP:0001549)2.06590936
58Short tibia (HP:0005736)2.06478814
59Lissencephaly (HP:0001339)2.06234889
60Absent speech (HP:0001344)2.05160981
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04898997
62Thyroid-stimulating hormone excess (HP:0002925)2.04461735
63Genital tract atresia (HP:0001827)2.04453775
64Abolished electroretinogram (ERG) (HP:0000550)2.03578745
65Inability to walk (HP:0002540)2.02660889
66Nephrogenic diabetes insipidus (HP:0009806)2.00411023
67Progressive cerebellar ataxia (HP:0002073)2.00388965
68Abnormal ciliary motility (HP:0012262)1.99954663
69Meckel diverticulum (HP:0002245)1.98857818
70Tubulointerstitial nephritis (HP:0001970)1.94933120
71Postaxial foot polydactyly (HP:0001830)1.94356967
72Polyuria (HP:0000103)1.93203394
73Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.89819091
74Congenital sensorineural hearing impairment (HP:0008527)1.87967868
75Severe muscular hypotonia (HP:0006829)1.87504025
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87134534
77Abnormal respiratory epithelium morphology (HP:0012253)1.86240846
78Abnormal respiratory motile cilium morphology (HP:0005938)1.86240846
79Generalized hypopigmentation of hair (HP:0011358)1.85358028
80Vaginal atresia (HP:0000148)1.85165584
81Renal cortical cysts (HP:0000803)1.82622215
82Preaxial hand polydactyly (HP:0001177)1.82503714
83Postaxial hand polydactyly (HP:0001162)1.79850039
84Protruding tongue (HP:0010808)1.78963111
85Male pseudohermaphroditism (HP:0000037)1.78623962
86Tubulointerstitial abnormality (HP:0001969)1.78254227
87Focal motor seizures (HP:0011153)1.78196293
88Abnormality of abdominal situs (HP:0011620)1.76564030
89Abdominal situs inversus (HP:0003363)1.76564030
90Hyperglycinemia (HP:0002154)1.76455770
91Patellar aplasia (HP:0006443)1.76241297
92Pachygyria (HP:0001302)1.76097010
93Dandy-Walker malformation (HP:0001305)1.75760959
943-Methylglutaconic aciduria (HP:0003535)1.74866529
95Colon cancer (HP:0003003)1.72784264
96Aplasia/Hypoplasia of the macula (HP:0008059)1.71958295
97Abnormality of the pons (HP:0007361)1.71678996
98Ectopic kidney (HP:0000086)1.71215577
99Hypoplasia of the pons (HP:0012110)1.71037204
100Aplasia/Hypoplasia of the patella (HP:0006498)1.68893051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.70879601
2ZAK3.05392045
3WNK32.96333848
4MAP4K22.72013594
5ADRBK22.69844302
6NUAK12.66195139
7BMPR1B2.65130133
8MAP3K42.15802588
9GRK12.14093811
10TAOK32.04121401
11MAPK132.02053268
12PINK11.99634250
13TIE11.86578191
14TNIK1.86259154
15CASK1.73946448
16TLK11.73114945
17WNK41.70630454
18STK391.70314782
19ACVR1B1.69340620
20TRIM281.48460082
21MARK11.45872738
22INSRR1.44118550
23OXSR11.42288547
24TXK1.29074087
25BRSK21.28699462
26MKNK21.27263351
27PLK41.23346663
28DYRK21.23307039
29CSNK1G11.22115516
30STK38L1.12447120
31CSNK1G31.11993816
32CSNK1A1L1.08825461
33CSNK1G21.05899699
34NTRK21.04132726
35PLK21.02799195
36MAP2K71.02616296
37MAP3K90.96892147
38EPHA40.93597542
39EIF2AK30.91605904
40VRK10.90952285
41PAK30.87869812
42MST40.86811190
43CDC70.86447291
44PRKCI0.86250530
45PRKCG0.86225432
46PLK10.81395894
47PRKCE0.80229821
48BCKDK0.78572693
49BCR0.77425760
50NEK60.74054700
51MUSK0.73289334
52PLK30.72882562
53PNCK0.72172929
54PKN10.71021095
55ADRBK10.70697688
56DAPK20.70481076
57CAMK10.69351292
58CSNK1D0.68862578
59NTRK30.65733343
60CDK90.65714613
61CAMKK20.62316596
62CAMK2A0.60698513
63PIK3CA0.59708344
64CDK190.56326788
65TGFBR10.55371596
66AURKA0.54200237
67IRAK10.54124052
68PRKACA0.53737198
69TNK20.53384071
70VRK20.53048118
71AKT30.51934379
72PHKG10.51619741
73PHKG20.51619741
74ATM0.51121501
75MARK30.50803684
76CHEK20.50099562
77SRPK10.49477167
78MKNK10.48924892
79TTK0.48748593
80STK30.47830342
81TEC0.47623631
82ATR0.47338754
83PRKD30.46576160
84WEE10.45958707
85FER0.45691742
86PRKG10.43962878
87PRKCZ0.43614848
88PRKCQ0.42944436
89PRKAA20.42809150
90PRKAA10.42607213
91ERBB30.41800827
92CSNK1A10.41795908
93NLK0.40592926
94GRK70.40547826
95CAMK40.39943447
96DYRK1A0.37749727
97CHUK0.37698788
98IKBKB0.36455555
99BRSK10.35924362
100CAMK1G0.35475640

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.10184583
2Basal transcription factors_Homo sapiens_hsa030222.87878501
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.50653884
4Fanconi anemia pathway_Homo sapiens_hsa034602.34199612
5Homologous recombination_Homo sapiens_hsa034402.32203070
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30473780
7Nicotine addiction_Homo sapiens_hsa050332.27814620
8Linoleic acid metabolism_Homo sapiens_hsa005912.26871735
9Caffeine metabolism_Homo sapiens_hsa002322.16441809
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14946946
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10279105
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01468925
13Butanoate metabolism_Homo sapiens_hsa006502.01105834
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99499482
15RNA degradation_Homo sapiens_hsa030181.96342198
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84683063
17Olfactory transduction_Homo sapiens_hsa047401.82053618
18Propanoate metabolism_Homo sapiens_hsa006401.80870361
19Ovarian steroidogenesis_Homo sapiens_hsa049131.80606851
20RNA polymerase_Homo sapiens_hsa030201.80119980
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76107070
22Nitrogen metabolism_Homo sapiens_hsa009101.72211538
23Oxidative phosphorylation_Homo sapiens_hsa001901.57183313
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.55062356
25Ether lipid metabolism_Homo sapiens_hsa005651.51303989
26Taste transduction_Homo sapiens_hsa047421.51175547
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50631525
28Protein export_Homo sapiens_hsa030601.49222657
29Morphine addiction_Homo sapiens_hsa050321.49028358
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44625465
31ABC transporters_Homo sapiens_hsa020101.40890434
32Tryptophan metabolism_Homo sapiens_hsa003801.30281772
33GABAergic synapse_Homo sapiens_hsa047271.28425709
34Selenocompound metabolism_Homo sapiens_hsa004501.23157155
35Parkinsons disease_Homo sapiens_hsa050121.21239724
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17117380
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.12989802
38Peroxisome_Homo sapiens_hsa041461.12634957
39Dorso-ventral axis formation_Homo sapiens_hsa043201.08453230
40Circadian rhythm_Homo sapiens_hsa047101.08374673
41Huntingtons disease_Homo sapiens_hsa050161.08196301
42Insulin secretion_Homo sapiens_hsa049111.03463305
43Glutamatergic synapse_Homo sapiens_hsa047241.02445148
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.00489512
45Non-homologous end-joining_Homo sapiens_hsa034500.99891104
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99203864
47Cardiac muscle contraction_Homo sapiens_hsa042600.99100918
48Nucleotide excision repair_Homo sapiens_hsa034200.96240098
49Chemical carcinogenesis_Homo sapiens_hsa052040.96200631
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.95508469
51Retinol metabolism_Homo sapiens_hsa008300.95093697
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94786613
53Serotonergic synapse_Homo sapiens_hsa047260.93096906
54Circadian entrainment_Homo sapiens_hsa047130.92075423
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91466720
56One carbon pool by folate_Homo sapiens_hsa006700.90904015
57Regulation of autophagy_Homo sapiens_hsa041400.90032592
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88495061
59Mismatch repair_Homo sapiens_hsa034300.88399855
60Base excision repair_Homo sapiens_hsa034100.83989394
61Purine metabolism_Homo sapiens_hsa002300.82868515
62Oocyte meiosis_Homo sapiens_hsa041140.80163980
63Arachidonic acid metabolism_Homo sapiens_hsa005900.78853968
64beta-Alanine metabolism_Homo sapiens_hsa004100.74463641
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.74019058
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72142911
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71342662
68RNA transport_Homo sapiens_hsa030130.70784881
69Alzheimers disease_Homo sapiens_hsa050100.62591567
70Metabolic pathways_Homo sapiens_hsa011000.61316561
71Calcium signaling pathway_Homo sapiens_hsa040200.60971683
72Mineral absorption_Homo sapiens_hsa049780.60550214
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56985240
74Salivary secretion_Homo sapiens_hsa049700.56864228
75Cell cycle_Homo sapiens_hsa041100.56709945
76p53 signaling pathway_Homo sapiens_hsa041150.56264219
77Glycerolipid metabolism_Homo sapiens_hsa005610.53848871
78Collecting duct acid secretion_Homo sapiens_hsa049660.52814735
79Proteasome_Homo sapiens_hsa030500.52198280
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49923170
81Vitamin digestion and absorption_Homo sapiens_hsa049770.49024528
82Fat digestion and absorption_Homo sapiens_hsa049750.48467066
83Arginine and proline metabolism_Homo sapiens_hsa003300.47826883
84Steroid biosynthesis_Homo sapiens_hsa001000.47083515
85Dopaminergic synapse_Homo sapiens_hsa047280.45798296
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45489330
87Pyrimidine metabolism_Homo sapiens_hsa002400.43142574
88Long-term depression_Homo sapiens_hsa047300.41374463
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41311774
90Histidine metabolism_Homo sapiens_hsa003400.38012516
91Fatty acid biosynthesis_Homo sapiens_hsa000610.37725629
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37643707
93Lysine degradation_Homo sapiens_hsa003100.37600174
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36360976
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.35951126
96Asthma_Homo sapiens_hsa053100.33732803
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33716875
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32739438
99Primary immunodeficiency_Homo sapiens_hsa053400.32714379
100Bile secretion_Homo sapiens_hsa049760.31479317

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