FBXW2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.23265020
2regulation of nuclear cell cycle DNA replication (GO:0033262)4.81010564
3positive regulation of gamma-delta T cell activation (GO:0046645)4.70965387
4interferon-gamma production (GO:0032609)4.59457826
5regulation of RNA export from nucleus (GO:0046831)4.04435882
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00540384
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00540384
8COPII vesicle coating (GO:0048208)3.95670116
9biotin metabolic process (GO:0006768)3.88822454
10regulation of B cell receptor signaling pathway (GO:0050855)3.88279223
11tRNA methylation (GO:0030488)3.70249958
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.67105104
13regulation of gamma-delta T cell differentiation (GO:0045586)3.65261908
14regulation of gamma-delta T cell activation (GO:0046643)3.61943872
15CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.60734504
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.56467405
17cytoplasmic mRNA processing body assembly (GO:0033962)3.53404594
18antigen processing and presentation of endogenous antigen (GO:0019883)3.52061518
19pore complex assembly (GO:0046931)3.51929990
20regulation of nucleobase-containing compound transport (GO:0032239)3.43466153
21Golgi transport vesicle coating (GO:0048200)3.39880185
22COPI coating of Golgi vesicle (GO:0048205)3.39880185
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39864965
24peptidyl-lysine dimethylation (GO:0018027)3.36644374
25protein localization to endosome (GO:0036010)3.31863708
26monoubiquitinated protein deubiquitination (GO:0035520)3.30906134
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29453167
28hepatocyte apoptotic process (GO:0097284)3.28465937
29translesion synthesis (GO:0019985)3.26237069
30regulation of histone H3-K27 methylation (GO:0061085)3.17823637
31mature B cell differentiation (GO:0002335)3.17636358
32folic acid metabolic process (GO:0046655)3.13509420
33negative regulation of DNA repair (GO:0045738)3.12502735
34maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11198182
35regulation of DNA-dependent DNA replication (GO:0090329)3.08474714
36regulation of sister chromatid cohesion (GO:0007063)3.00089385
37hypotonic response (GO:0006971)2.99705929
38histone mRNA catabolic process (GO:0071044)2.98832390
39negative regulation of protein autophosphorylation (GO:0031953)2.97744058
40negative regulation of fatty acid transport (GO:2000192)2.96950541
41antigen processing and presentation via MHC class Ib (GO:0002475)2.95627534
42pre-miRNA processing (GO:0031054)2.94778524
43negative regulation of glycoprotein biosynthetic process (GO:0010561)2.94763501
44T cell lineage commitment (GO:0002360)2.94368789
45necrotic cell death (GO:0070265)2.93334112
46negative regulation of type 2 immune response (GO:0002829)2.90338916
47mature B cell differentiation involved in immune response (GO:0002313)2.86687112
48mitotic chromosome condensation (GO:0007076)2.86592399
49negative regulation of protein localization to plasma membrane (GO:1903077)2.84643536
50pericardium development (GO:0060039)2.82829907
51necroptotic process (GO:0070266)2.82622792
52phosphatidylethanolamine metabolic process (GO:0046337)2.81327351
53programmed necrotic cell death (GO:0097300)2.80258054
54histone H4-K16 acetylation (GO:0043984)2.78788434
55NIK/NF-kappaB signaling (GO:0038061)2.77663657
56detection of other organism (GO:0098543)2.77255700
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.75577817
58phosphatidylethanolamine biosynthetic process (GO:0006646)2.72377970
59negative regulation of granulocyte differentiation (GO:0030853)2.71077960
60mRNA stabilization (GO:0048255)2.70742207
61RNA stabilization (GO:0043489)2.70742207
62cellular response to reactive nitrogen species (GO:1902170)2.70231642
63negative regulation of fibroblast apoptotic process (GO:2000270)2.68694076
64nuclear pore complex assembly (GO:0051292)2.68259645
65protein export from nucleus (GO:0006611)2.68016006
66positive regulation of isotype switching (GO:0045830)2.67828021
67DNA synthesis involved in DNA repair (GO:0000731)2.66535747
68I-kappaB phosphorylation (GO:0007252)2.66346122
69daunorubicin metabolic process (GO:0044597)2.65322982
70polyketide metabolic process (GO:0030638)2.65322982
71doxorubicin metabolic process (GO:0044598)2.65322982
72response to epidermal growth factor (GO:0070849)2.62721236
73embryonic process involved in female pregnancy (GO:0060136)2.62705047
74embryonic hemopoiesis (GO:0035162)2.60092697
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59769621
76vesicle coating (GO:0006901)2.59116013
77glucocorticoid receptor signaling pathway (GO:0042921)2.58969338
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.58874151
79negative T cell selection (GO:0043383)2.57942721
80cell-substrate junction assembly (GO:0007044)2.57191450
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57137198
82negative regulation of stress fiber assembly (GO:0051497)2.57012359
83regulation of translational termination (GO:0006449)2.56490049
84regulation of helicase activity (GO:0051095)2.56036099
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55101822
86positive regulation of CREB transcription factor activity (GO:0032793)2.54698036
87valine metabolic process (GO:0006573)2.54113530
88regulation of response to interferon-gamma (GO:0060330)2.53385993
89nuclear pore organization (GO:0006999)2.52762667
90mRNA splice site selection (GO:0006376)2.51211777
91response to laminar fluid shear stress (GO:0034616)2.50899159
92negative regulation of actin filament bundle assembly (GO:0032232)2.50561229
93DNA replication initiation (GO:0006270)2.50521022
94regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50150951
95regulation of DNA endoreduplication (GO:0032875)2.50087715
96negative regulation of phagocytosis (GO:0050765)2.49851250
97iron ion import (GO:0097286)2.49654048
98spindle assembly checkpoint (GO:0071173)2.49559799
99peptidyl-threonine phosphorylation (GO:0018107)2.49132599
100histone H4-K5 acetylation (GO:0043981)2.49092592
101histone H4-K8 acetylation (GO:0043982)2.49092592
102mitotic spindle assembly checkpoint (GO:0007094)2.48686369
103peptidyl-threonine modification (GO:0018210)2.48091872
104positive regulation of DNA-dependent DNA replication (GO:2000105)2.47468015
105spindle assembly involved in mitosis (GO:0090307)2.45518565
106negative regulation of interleukin-12 production (GO:0032695)2.45210785
107regulation of establishment of cell polarity (GO:2000114)2.45089544
108T cell homeostasis (GO:0043029)2.44901214
109nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.44592578
110regulation of granulocyte differentiation (GO:0030852)2.44215450
111definitive hemopoiesis (GO:0060216)2.44213035
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.44012977
113negative regulation of sister chromatid segregation (GO:0033046)2.44012977
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.44012977
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.44012977
116positive regulation of protein import into nucleus, translocation (GO:0033160)2.43265946
117phospholipid translocation (GO:0045332)2.42604274
118lipid translocation (GO:0034204)2.42604274
119NLS-bearing protein import into nucleus (GO:0006607)2.42312970
120hemidesmosome assembly (GO:0031581)2.41695036
121positive regulation of B cell differentiation (GO:0045579)2.41541638
122inflammatory response to antigenic stimulus (GO:0002437)2.40533951
123DNA deamination (GO:0045006)2.39700391
124carnitine metabolic process (GO:0009437)2.39494548
125execution phase of apoptosis (GO:0097194)2.39372897
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.39361849
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.39361849
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.39361849
129peptidyl-lysine trimethylation (GO:0018023)2.39016136
130regulation of RIG-I signaling pathway (GO:0039535)2.38833267
131protein K6-linked ubiquitination (GO:0085020)2.38150341
1323-UTR-mediated mRNA stabilization (GO:0070935)2.38047419
133detection of bacterium (GO:0016045)2.35499072
134amino-acid betaine metabolic process (GO:0006577)2.35403025
135regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35085009
136negative regulation of chromosome segregation (GO:0051985)2.34993688
137histone H3-K36 demethylation (GO:0070544)2.34690575
138positive regulation of cell cycle checkpoint (GO:1901978)2.33897752
139lymphocyte homeostasis (GO:0002260)2.33437252
140cellular response to epidermal growth factor stimulus (GO:0071364)2.31663280
141response to interleukin-15 (GO:0070672)2.31312920
142positive regulation of natural killer cell differentiation (GO:0032825)2.30746314
143intra-S DNA damage checkpoint (GO:0031573)2.30138933
144regulation of centriole replication (GO:0046599)2.29985357
145negative regulation of erythrocyte differentiation (GO:0045647)2.29464354
146cell-substrate adherens junction assembly (GO:0007045)2.29441352
147focal adhesion assembly (GO:0048041)2.29441352
148regulation of cholesterol storage (GO:0010885)2.29108991
149positive regulation of histone deacetylation (GO:0031065)2.28858253
150N-terminal protein amino acid acetylation (GO:0006474)2.28717904
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.28622152
152corticosteroid receptor signaling pathway (GO:0031958)2.28118966
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27723106
154regulation of Rac protein signal transduction (GO:0035020)2.27298947
155positive regulation of granulocyte differentiation (GO:0030854)2.27181519
156positive regulation of cellular response to insulin stimulus (GO:1900078)2.26650114
157histone lysine demethylation (GO:0070076)2.26637140
158interkinetic nuclear migration (GO:0022027)2.26395486
159regulation of sequestering of triglyceride (GO:0010889)2.25819526
160natural killer cell differentiation (GO:0001779)2.24301036
161Golgi organization (GO:0007030)2.23327402
162protein targeting to vacuole (GO:0006623)2.23291291
163protein targeting to lysosome (GO:0006622)2.23291291
164establishment of protein localization to vacuole (GO:0072666)2.23291291
165protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.19641927
166cell adhesion mediated by integrin (GO:0033627)2.18238235
167DNA duplex unwinding (GO:0032508)2.17276403
168chondrocyte development (GO:0002063)2.16679656
169histone H3-K9 modification (GO:0061647)2.16133073
170histone H3-K9 demethylation (GO:0033169)2.15907401
171regulation of NFAT protein import into nucleus (GO:0051532)2.15322327
172embryonic retina morphogenesis in camera-type eye (GO:0060059)2.14642669
173desmosome organization (GO:0002934)2.14579105
174sister chromatid cohesion (GO:0007062)2.14391193
175genitalia morphogenesis (GO:0035112)2.13760507
176snRNA transcription (GO:0009301)2.11979846
177localization within membrane (GO:0051668)2.11771573
178embryonic camera-type eye morphogenesis (GO:0048596)2.11566592
179early endosome to late endosome transport (GO:0045022)2.10383944
180histone demethylation (GO:0016577)2.08698741
181negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.07471225
182Golgi to endosome transport (GO:0006895)2.06791307
183cellular response to ethanol (GO:0071361)2.06281969
184skin morphogenesis (GO:0043589)2.04604088
185maternal placenta development (GO:0001893)2.04163704
186regulation of hippo signaling (GO:0035330)2.04001349
187plasma lipoprotein particle assembly (GO:0034377)2.03893298
188adherens junction assembly (GO:0034333)2.03379377
189hippo signaling (GO:0035329)2.01619023
190histone H3-K9 methylation (GO:0051567)2.01522559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13334453
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.52420228
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00193291
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.96779511
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.34526522
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.24000011
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.16563386
8GATA1_22025678_ChIP-Seq_K562_Human3.15208225
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92561271
10MYC_22102868_ChIP-Seq_BL_Human2.84376541
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56522297
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52124403
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44694193
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42519223
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.36839082
16SCL_19346495_ChIP-Seq_HPC-7_Human2.34346908
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33365632
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.30495353
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.27976701
20MYB_26560356_Chip-Seq_TH1_Human2.06235533
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06097285
22RUNX_20019798_ChIP-Seq_JUKART_Human1.96414448
23MAF_26560356_Chip-Seq_TH1_Human1.91901252
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90098269
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.88059405
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85142088
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80537654
28CIITA_25753668_ChIP-Seq_RAJI_Human1.80330276
29AR_21909140_ChIP-Seq_LNCAP_Human1.78848937
30MYB_26560356_Chip-Seq_TH2_Human1.78383503
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78346802
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.78195894
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77315255
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.75299424
35* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74871241
36* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72756661
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72372026
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72351836
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70813141
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63629338
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62538076
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62441715
43SPI1_23547873_ChIP-Seq_NB4_Human1.61311858
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60364641
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59531116
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59531116
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.59112999
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59084966
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57123602
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.55334892
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54969491
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53153197
53TCF7_22412390_ChIP-Seq_EML_Mouse1.53056518
54* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52073349
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50366291
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50312769
57BRD4_25478319_ChIP-Seq_HGPS_Human1.49225059
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47543170
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46336795
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45355137
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44806892
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44471377
63* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44426155
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43774242
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41058186
66SPI1_23127762_ChIP-Seq_K562_Human1.40756800
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40355167
68UTX_26944678_Chip-Seq_JUKART_Human1.39503102
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38631278
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.38227318
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36571043
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36526686
73VDR_21846776_ChIP-Seq_THP-1_Human1.36157042
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35714480
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35473456
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33376474
77* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31004220
78TP53_16413492_ChIP-PET_HCT116_Human1.30833338
79* FOXA2_19822575_ChIP-Seq_HepG2_Human1.30628686
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29154474
81PU_27001747_Chip-Seq_BMDM_Mouse1.27928931
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27833624
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27180495
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.26975724
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26930259
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26056974
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26050976
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24800738
89CHD1_26751641_Chip-Seq_LNCaP_Human1.24680268
90VDR_23849224_ChIP-Seq_CD4+_Human1.23816282
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21470009
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.20642831
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20560452
94* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20455972
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17960971
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.17918552
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17896056
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.17725173
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17097536
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16751924
101* GATA1_19941826_ChIP-Seq_K562_Human1.16511943
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16109471
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15469505
104* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15314719
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14149116
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14140816
107AHR_22903824_ChIP-Seq_MCF-7_Human1.13078613
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12169650
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11147617
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.10416126
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10252635
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10252635
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09541850
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09351200
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08893067
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08158577
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.07790189
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07774319
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04966776
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04320266
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04283157
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04203645
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.04107957
124TCF4_18268006_ChIP-ChIP_LS174T_Human1.03952660
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03791609
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02605494
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02448193
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01660356
129RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00892869
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99865406
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99772663
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99253650
133VDR_24763502_ChIP-Seq_THP-1_Human0.99189478
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.99103455
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98683850
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98357180
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.97676813
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96997926
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95703511
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94352667
141ZNF263_19887448_ChIP-Seq_K562_Human0.94189039
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.93961287
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92742948
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.92505262
145MAF_26560356_Chip-Seq_TH2_Human0.91847196
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.91451522
147GATA6_25053715_ChIP-Seq_YYC3_Human0.90245075
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89965145
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89632087
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.89525310
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88277757
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88204799
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.88098260
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.88098260
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.87234726
156NCOR1_26117541_ChIP-Seq_K562_Human0.86466940
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86221829
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85098621
159STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84384873
160* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82764430
161CLOCK_20551151_ChIP-Seq_293T_Human0.81996967
162TFEB_21752829_ChIP-Seq_HELA_Human0.81925065
163RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80823588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.25160780
2MP0002877_abnormal_melanocyte_morpholog3.06934659
3MP0002132_abnormal_respiratory_system3.05452901
4MP0002396_abnormal_hematopoietic_system2.94205271
5MP0002009_preneoplasia2.88982832
6MP0008057_abnormal_DNA_replication2.87272520
7MP0001835_abnormal_antigen_presentation2.76282671
8MP0005409_darkened_coat_color2.73269371
9MP0003111_abnormal_nucleus_morphology2.67910719
10MP0003566_abnormal_cell_adhesion2.61048900
11MP0000569_abnormal_digit_pigmentation2.39929485
12MP0010307_abnormal_tumor_latency2.26164177
13MP0003763_abnormal_thymus_physiology2.24900723
14MP0005397_hematopoietic_system_phenotyp2.21228564
15MP0001545_abnormal_hematopoietic_system2.21228564
16MP0004808_abnormal_hematopoietic_stem2.13686547
17MP0003724_increased_susceptibility_to2.12320240
18MP0003656_abnormal_erythrocyte_physiolo2.09210568
19MP0005174_abnormal_tail_pigmentation2.07355840
20MP0008438_abnormal_cutaneous_collagen2.04111926
21MP0000685_abnormal_immune_system2.01543562
22MP0009278_abnormal_bone_marrow1.96836752
23MP0004233_abnormal_muscle_weight1.94895877
24MP0008260_abnormal_autophagy1.94584880
25MP0002166_altered_tumor_susceptibility1.93371328
26MP0001800_abnormal_humoral_immune1.92626167
27MP0003941_abnormal_skin_development1.90461039
28MP0002876_abnormal_thyroid_physiology1.87361299
29MP0005671_abnormal_response_to1.86962239
30MP0000015_abnormal_ear_pigmentation1.83392372
31MP0004185_abnormal_adipocyte_glucose1.80042490
32MP0001915_intracranial_hemorrhage1.80026728
33MP0002398_abnormal_bone_marrow1.79314429
34MP0004130_abnormal_muscle_cell1.76933449
35MP0001853_heart_inflammation1.75719469
36MP0010094_abnormal_chromosome_stability1.75487325
37MP0003693_abnormal_embryo_hatching1.75463727
38MP0003091_abnormal_cell_migration1.70764126
39MP0005365_abnormal_bile_salt1.70154628
40MP0002722_abnormal_immune_system1.60266237
41MP0000689_abnormal_spleen_morphology1.59626269
42MP0003300_gastrointestinal_ulcer1.58210589
43MP0004264_abnormal_extraembryonic_tissu1.57692786
44MP0005075_abnormal_melanosome_morpholog1.56573106
45MP0002452_abnormal_antigen_presenting1.55943297
46MP0005275_abnormal_skin_tensile1.54716603
47MP0002723_abnormal_immune_serum1.53477788
48MP0006054_spinal_hemorrhage1.51422919
49MP0000703_abnormal_thymus_morphology1.51190738
50MP0001188_hyperpigmentation1.50994898
51MP0002006_tumorigenesis1.50162244
52MP0004147_increased_porphyrin_level1.48910872
53MP0002420_abnormal_adaptive_immunity1.48505229
54MP0005387_immune_system_phenotype1.47716632
55MP0001790_abnormal_immune_system1.47716632
56MP0002086_abnormal_extraembryonic_tissu1.47576888
57MP0001819_abnormal_immune_cell1.47223479
58MP0003436_decreased_susceptibility_to1.46820103
59MP0002088_abnormal_embryonic_growth/wei1.45318204
60MP0003984_embryonic_growth_retardation1.44444709
61MP0005025_abnormal_response_to1.40596525
62MP0004947_skin_inflammation1.40222547
63MP0005000_abnormal_immune_tolerance1.39903138
64MP0000716_abnormal_immune_system1.39873685
65MP0001873_stomach_inflammation1.39397515
66MP0008058_abnormal_DNA_repair1.38824449
67MP0008877_abnormal_DNA_methylation1.38268434
68MP0003077_abnormal_cell_cycle1.37466956
69MP0002419_abnormal_innate_immunity1.36754660
70MP0003828_pulmonary_edema1.36095183
71MP0010234_abnormal_vibrissa_follicle1.35536064
72MP0001851_eye_inflammation1.35234569
73MP0002060_abnormal_skin_morphology1.34818794
74MP0000858_altered_metastatic_potential1.34594060
75MP0009333_abnormal_splenocyte_physiolog1.34300326
76MP0008007_abnormal_cellular_replicative1.34259349
77MP0001672_abnormal_embryogenesis/_devel1.31796600
78MP0005380_embryogenesis_phenotype1.31796600
79MP0005076_abnormal_cell_differentiation1.31490929
80MP0003890_abnormal_embryonic-extraembry1.31110227
81MP0009840_abnormal_foam_cell1.30060354
82MP0009672_abnormal_birth_weight1.30029404
83MP0010352_gastrointestinal_tract_polyps1.29921642
84MP0002796_impaired_skin_barrier1.28565442
85MP0009785_altered_susceptibility_to1.28561637
86MP0001958_emphysema1.28175023
87MP0005464_abnormal_platelet_physiology1.27272717
88MP0002429_abnormal_blood_cell1.25970275
89MP0000350_abnormal_cell_proliferation1.25850379
90MP0009764_decreased_sensitivity_to1.25480223
91MP0000490_abnormal_crypts_of1.25188887
92MP0005621_abnormal_cell_physiology1.23709122
93MP0003868_abnormal_feces_composition1.23267427
94MP0003191_abnormal_cellular_cholesterol1.23092411
95MP0001730_embryonic_growth_arrest1.22915641
96MP0004272_abnormal_basement_membrane1.22843238
97MP0003453_abnormal_keratinocyte_physiol1.22642641
98MP0002254_reproductive_system_inflammat1.22141449
99MP0000767_abnormal_smooth_muscle1.19579484
100MP0002405_respiratory_system_inflammati1.19464464
101MP0009763_increased_sensitivity_to1.18563405
102MP0006138_congestive_heart_failure1.16936025
103MP0000609_abnormal_liver_physiology1.16654062
104MP0005085_abnormal_gallbladder_physiolo1.14228681
105MP0009765_abnormal_xenobiotic_induced1.14188272
106MP0002095_abnormal_skin_pigmentation1.12239813
107MP0003950_abnormal_plasma_membrane1.11125487
108MP0000371_diluted_coat_color1.10817443
109MP0002139_abnormal_hepatobiliary_system1.10195411
110MP0001919_abnormal_reproductive_system1.09962636
111MP0003221_abnormal_cardiomyocyte_apopto1.08710927
112MP0010368_abnormal_lymphatic_system1.07868600
113MP0001849_ear_inflammation1.07013910
114MP0000377_abnormal_hair_follicle1.06465601
115MP0003115_abnormal_respiratory_system1.05602448
116MP0000428_abnormal_craniofacial_morphol1.05249974
117MP0002928_abnormal_bile_duct1.05247137
118MP0004197_abnormal_fetal_growth/weight/1.04077124
119MP0002138_abnormal_hepatobiliary_system1.03893872
120MP0005248_abnormal_Harderian_gland1.03721215
121MP0010678_abnormal_skin_adnexa1.03477741
122MP0005451_abnormal_body_composition1.01029125
123MP0009703_decreased_birth_body1.01025312
124MP0002168_other_aberrant_phenotype0.99656677
125MP0005666_abnormal_adipose_tissue0.99385658
126MP0000383_abnormal_hair_follicle0.98251222
127MP0010155_abnormal_intestine_physiology0.97337383
128MP0001845_abnormal_inflammatory_respons0.96705348
129MP0001216_abnormal_epidermal_layer0.95121739
130MP0002971_abnormal_brown_adipose0.94344959
131MP0005023_abnormal_wound_healing0.94248857
132MP0008469_abnormal_protein_level0.93632581
133MP0002080_prenatal_lethality0.92211571
134MP0008995_early_reproductive_senescence0.91108240
135MP0002970_abnormal_white_adipose0.90613993
136MP0003705_abnormal_hypodermis_morpholog0.89679409
137MP0002925_abnormal_cardiovascular_devel0.89477665
138MP0002735_abnormal_chemical_nociception0.88974601
139MP0003045_fibrosis0.87624048
140MP0005388_respiratory_system_phenotype0.87259865
141MP0002133_abnormal_respiratory_system0.87259865
142MP0005501_abnormal_skin_physiology0.87216271
143MP0001661_extended_life_span0.86859448
144MP0010329_abnormal_lipoprotein_level0.85212438
145MP0003448_altered_tumor_morphology0.85171329
146MP0004510_myositis0.84433915
147MP0001764_abnormal_homeostasis0.84364875
148MP0002084_abnormal_developmental_patter0.84209428
149MP0009115_abnormal_fat_cell0.83893565
150MP0000627_abnormal_mammary_gland0.83848286
151MP0005319_abnormal_enzyme/_coenzyme0.82909319
152MP0002019_abnormal_tumor_incidence0.82836854
153MP0009931_abnormal_skin_appearance0.82780539
154MP0001697_abnormal_embryo_size0.82675446
155MP0005384_cellular_phenotype0.81954737
156MP0004381_abnormal_hair_follicle0.81066067
157MP0002896_abnormal_bone_mineralization0.80894368
158MP0003303_peritoneal_inflammation0.80707238
159MP0004957_abnormal_blastocyst_morpholog0.79446260
160MP0001666_abnormal_nutrient_absorption0.79308418
161MP0000598_abnormal_liver_morphology0.79216664
162MP0000733_abnormal_muscle_development0.75708494
163MP0005334_abnormal_fat_pad0.75220811
164MP0000427_abnormal_hair_cycle0.74797086
165MP0003943_abnormal_hepatobiliary_system0.74535359
166MP0002128_abnormal_blood_circulation0.73457553
167MP0003279_aneurysm0.73412075
168MP0010630_abnormal_cardiac_muscle0.73318280
169MP0000432_abnormal_head_morphology0.73280459
170MP0000681_abnormal_thyroid_gland0.72469844
171MP0001879_abnormal_lymphatic_vessel0.71696688
172MP0001533_abnormal_skeleton_physiology0.71507016
173MP0005647_abnormal_sex_gland0.70930255

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the prostate (HP:0008775)3.85444147
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78060467
3Hematochezia (HP:0002573)3.53749245
4Prostate neoplasm (HP:0100787)3.38709808
5Chromsome breakage (HP:0040012)3.27998488
6Arterial thrombosis (HP:0004420)3.11887937
7Spinal cord lesions (HP:0100561)3.06711598
8Syringomyelia (HP:0003396)3.06711598
9Subacute progressive viral hepatitis (HP:0006572)2.92271071
10Mediastinal lymphadenopathy (HP:0100721)2.91620065
11Myocardial infarction (HP:0001658)2.83230320
12Ankyloglossia (HP:0010296)2.78385068
13Arterial tortuosity (HP:0005116)2.71923839
14Absent frontal sinuses (HP:0002688)2.69489085
15Asymmetry of the thorax (HP:0001555)2.69223255
16Frequent falls (HP:0002359)2.65637635
17Acute lymphatic leukemia (HP:0006721)2.65548351
18Osteolytic defects of the hand bones (HP:0009699)2.64125935
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.64125935
20Vascular tortuosity (HP:0004948)2.63614928
21Pelvic girdle muscle weakness (HP:0003749)2.61689264
22Papillary thyroid carcinoma (HP:0002895)2.61059189
23Birth length less than 3rd percentile (HP:0003561)2.57162763
24Panhypogammaglobulinemia (HP:0003139)2.54258741
25Amaurosis fugax (HP:0100576)2.52976988
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.50814815
27Clubbing of toes (HP:0100760)2.49126887
28Hypochromic microcytic anemia (HP:0004840)2.45877973
29Azoospermia (HP:0000027)2.45201223
30Abnormality of oral frenula (HP:0000190)2.44423281
31Epistaxis (HP:0000421)2.44128457
32T lymphocytopenia (HP:0005403)2.42895481
33Microcytic anemia (HP:0001935)2.40690822
34Fair hair (HP:0002286)2.40637241
35Neoplasm of the adrenal cortex (HP:0100641)2.35438531
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.33287116
37Premature rupture of membranes (HP:0001788)2.32573168
38Recurrent viral infections (HP:0004429)2.32095703
39Pulmonary infiltrates (HP:0002113)2.31084820
40Recurrent fungal infections (HP:0002841)2.30932069
41Polycythemia (HP:0001901)2.30123767
42Aortic aneurysm (HP:0004942)2.29290602
43Acute myeloid leukemia (HP:0004808)2.28157989
44Abnormality of T cell number (HP:0011839)2.27792611
45Deep philtrum (HP:0002002)2.27738452
46Protrusio acetabuli (HP:0003179)2.26062013
47Cheilitis (HP:0100825)2.25926434
48Abnormality of DNA repair (HP:0003254)2.25068565
49Encephalitis (HP:0002383)2.25005131
50Prolonged bleeding time (HP:0003010)2.22474517
51Dilatation of the ascending aorta (HP:0005111)2.22360785
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.21839608
53Abnormality of chromosome stability (HP:0003220)2.21452239
54Meckel diverticulum (HP:0002245)2.21059677
55Abnormality of male internal genitalia (HP:0000022)2.20467504
56Mitral valve prolapse (HP:0001634)2.18828105
57Microvesicular hepatic steatosis (HP:0001414)2.16662757
58Abnormality of the preputium (HP:0100587)2.15984680
59Aortic dissection (HP:0002647)2.14899787
60Skull defect (HP:0001362)2.13800406
61Sensorimotor neuropathy (HP:0007141)2.13664286
62Action tremor (HP:0002345)2.12745212
63Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11501906
64Spontaneous hematomas (HP:0007420)2.10158520
65Hemoptysis (HP:0002105)2.09905761
66Myositis (HP:0100614)2.08409876
67Thrombophlebitis (HP:0004418)2.08153250
68Heterotopia (HP:0002282)2.08121112
69Flat acetabular roof (HP:0003180)2.07232548
70Hypertriglyceridemia (HP:0002155)2.07071926
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04527387
72Gastrointestinal infarctions (HP:0005244)2.03787358
73Abnormality of pyrimidine metabolism (HP:0004353)2.03635102
74Curly hair (HP:0002212)2.03330785
75Viral hepatitis (HP:0006562)2.03307442
76Relative macrocephaly (HP:0004482)2.02918248
77Termporal pattern (HP:0011008)2.01956190
78Insidious onset (HP:0003587)2.01956190
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01927381
80Abnormal spermatogenesis (HP:0008669)2.01470455
81Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.01192955
82Abnormality of alanine metabolism (HP:0010916)2.01108257
83Hyperalaninemia (HP:0003348)2.01108257
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01108257
85Overgrowth (HP:0001548)2.00957770
86Gingival bleeding (HP:0000225)2.00892487
87Eczematoid dermatitis (HP:0000976)1.99948352
88Granulocytopenia (HP:0001913)1.98995767
89Shoulder girdle muscle weakness (HP:0003547)1.98720627
90Meningitis (HP:0001287)1.97660198
91Abnormality of the ileum (HP:0001549)1.97422179
92Reduced subcutaneous adipose tissue (HP:0003758)1.96440952
93Recurrent cutaneous fungal infections (HP:0011370)1.95735146
94Chronic mucocutaneous candidiasis (HP:0002728)1.95735146
95Joint swelling (HP:0001386)1.94296594
96Pulmonary embolism (HP:0002204)1.94046357
97Vertebral arch anomaly (HP:0008438)1.93750920
98Eosinophilia (HP:0001880)1.93722926
99Generalized hypopigmentation of hair (HP:0011358)1.93044530
100Reduced antithrombin III activity (HP:0001976)1.92900474
101Dislocated radial head (HP:0003083)1.92891717
102Aortic valve stenosis (HP:0001650)1.92143500
103Advanced eruption of teeth (HP:0006288)1.91988798
104Abnormality of the fingertips (HP:0001211)1.91567504
105Abnormality of the hip-girdle musculature (HP:0001445)1.89746190
106Abnormality of the musculature of the pelvis (HP:0001469)1.89746190
107Coarse hair (HP:0002208)1.89669180
108Gastrointestinal carcinoma (HP:0002672)1.88894363
109Malignant gastrointestinal tract tumors (HP:0006749)1.88894363
110Persistence of primary teeth (HP:0006335)1.87378861
111Periodontitis (HP:0000704)1.87274905
112Abnormality of T cells (HP:0002843)1.87059868
113Joint hemorrhage (HP:0005261)1.86353225
114Poikilocytosis (HP:0004447)1.85658968
115Volvulus (HP:0002580)1.85337563
116Deep venous thrombosis (HP:0002625)1.85053214
117Chest pain (HP:0100749)1.84840298
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84478533
119Pustule (HP:0200039)1.84220597
120Abnormal foot bone ossification (HP:0010675)1.83174130
121Abnormal platelet volume (HP:0011876)1.83136252
122Uterine leiomyosarcoma (HP:0002891)1.82820456
123Leiomyosarcoma (HP:0100243)1.82820456
124Abnormality of the carotid arteries (HP:0005344)1.82510490
125IgG deficiency (HP:0004315)1.81660515
126Transitional cell carcinoma of the bladder (HP:0006740)1.81401892
127Unilateral renal agenesis (HP:0000122)1.81147297
128Right ventricular cardiomyopathy (HP:0011663)1.80744542
129Increased number of teeth (HP:0011069)1.79837980
130Narrow palate (HP:0000189)1.79366181
131Myelodysplasia (HP:0002863)1.79291538
132Increased mean platelet volume (HP:0011877)1.78509897
133Sandal gap (HP:0001852)1.78365200
134B lymphocytopenia (HP:0010976)1.78184156
135Abnormality of B cell number (HP:0010975)1.78184156
136Leukopenia (HP:0001882)1.77463663
137Absent thumb (HP:0009777)1.77024689
138Anorexia (HP:0002039)1.76799626
139Aneurysm (HP:0002617)1.76686606
140Gingivitis (HP:0000230)1.76011775
141Peritonitis (HP:0002586)1.74923747
142Abnormality of the epiphyses of the hand (HP:0005924)1.73919958
143Capillary hemangiomas (HP:0005306)1.73274539
144Chronic obstructive pulmonary disease (HP:0006510)1.73264947
145Obstructive lung disease (HP:0006536)1.73264947
146Optic neuritis (HP:0100653)1.73042703
147Retrobulbar optic neuritis (HP:0100654)1.73042703
148Natal tooth (HP:0000695)1.73028100
149Abnormality of the common coagulation pathway (HP:0010990)1.71552859
150Abnormality of the hepatic vasculature (HP:0006707)1.70086563
151Chronic otitis media (HP:0000389)1.67965987
152Cubitus valgus (HP:0002967)1.67914027
153Thyroid carcinoma (HP:0002890)1.67178688
154Bladder carcinoma (HP:0002862)1.66876408
155Bladder neoplasm (HP:0009725)1.66876408
156Lymphoma (HP:0002665)1.66704472
157Recurrent abscess formation (HP:0002722)1.66666805
158Restrictive lung disease (HP:0002091)1.66187537
159Ureteral stenosis (HP:0000071)1.65569072
160Long eyelashes (HP:0000527)1.64514240
161Abnormality of the radial head (HP:0003995)1.64341399
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63461392
163Low anterior hairline (HP:0000294)1.63374581
164Esophageal varix (HP:0002040)1.62668745
165Enlarged penis (HP:0000040)1.62187160
166Thickened calvaria (HP:0002684)1.61517786
167Abnormal platelet function (HP:0011869)1.61348643
168Metaphyseal cupping (HP:0003021)1.60969734
169Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.60823740
170Blue irides (HP:0000635)1.60206191
171Atrophic scars (HP:0001075)1.59589179
172Hypoplasia of the thymus (HP:0000778)1.59027927
173Sparse lateral eyebrow (HP:0005338)1.58222160
174Macroorchidism (HP:0000053)1.57625170
175Prominent nose (HP:0000448)1.55666543
176Delayed closure of the anterior fontanelle (HP:0001476)1.54309237
177Abnormality of the left ventricular outflow tract (HP:0011103)1.54188006
178Subaortic stenosis (HP:0001682)1.54188006
179Nephroblastoma (Wilms tumor) (HP:0002667)1.52989288
180Aplasia cutis congenita (HP:0001057)1.52762494
181Cystic hygroma (HP:0000476)1.51600306
182Mitral stenosis (HP:0001718)1.51211995
183Cerebral aneurysm (HP:0004944)1.50367129
184Renal cell carcinoma (HP:0005584)1.48082434
185Blue sclerae (HP:0000592)1.47799083
186Abnormal cartilage morphology (HP:0002763)1.47436849
187Tetraparesis (HP:0002273)1.47032359
188Menorrhagia (HP:0000132)1.46206626
189Embryonal renal neoplasm (HP:0011794)1.45941716
190Wormian bones (HP:0002645)1.45624975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK2.94923348
2FLT32.83488175
3IRAK32.52759642
4PRPF4B2.41679882
5BRD42.27815623
6RPS6KA42.25253592
7JAK32.23067158
8LATS12.21629471
9CAMK1D2.18856094
10MKNK12.14886481
11TXK2.14079387
12PKN22.11845920
13NEK92.11749154
14EEF2K2.01115749
15NLK1.97685620
16TAOK21.95176121
17MAP2K31.94080354
18EIF2AK11.92842605
19TRIB31.92339977
20MAP3K61.91186424
21PIK3CG1.90782845
22SIK11.81561572
23SMG11.74165697
24ACVR1B1.73718930
25STK161.73485541
26KSR21.72005837
27KDR1.69844807
28TGFBR21.69257170
29MAP3K101.67496896
30MAP4K11.66515823
31ZAP701.56578010
32TEC1.55769596
33KSR11.47770238
34JAK11.45637994
35MAP3K21.41598282
36EIF2AK31.39617190
37WNK11.38843486
38FGFR41.33727110
39NEK21.33019120
40SIK31.32969624
41MAP3K141.31959132
42AKT31.30032650
43TAOK11.30019123
44KIT1.28892733
45SIK21.28617452
46SCYL21.27088367
47TYK21.26174853
48SRPK11.25279476
49IRAK41.22237807
50SGK31.20229490
51CDK91.19658065
52IKBKB1.19059546
53TRPM71.18775589
54RAF11.18127723
55MKNK21.18084165
56MTOR1.08392423
57MAP3K31.08111800
58RET1.07826672
59FES1.07662803
60ICK1.05545806
61RIPK11.04858403
62ITK1.04591130
63PTK61.04302624
64IKBKE1.03343060
65TSSK61.01437786
66CAMKK21.00718014
67YES10.99513214
68MELK0.99219361
69FRK0.97859432
70TTK0.96057202
71MAP3K130.93739966
72NEK60.93624526
73FGFR30.92610903
74BTK0.91536863
75EIF2AK20.88585132
76STK30.88224162
77ALK0.87758636
78INSRR0.86475131
79CDK40.86403513
80PBK0.86345048
81MARK30.86178832
82PIM10.85925630
83EPHA20.85634634
84CDK120.84942632
85MAPK110.84326836
86RIPK40.84205592
87LATS20.82914945
88SYK0.82836890
89CDK60.82801609
90ATR0.81874187
91CAMK1G0.81245302
92MAP3K10.80595179
93MAP3K110.79855186
94VRK10.79421682
95PINK10.79241069
96PAK40.78966591
97CAMKK10.78876939
98DMPK0.78644222
99BLK0.76615384
100STK380.76135017
101CHUK0.75465868
102TBK10.74521599
103GRK10.74394525
104STK40.74020667
105MST1R0.73484287
106NTRK30.72254644
107DYRK30.71514032
108NEK10.71183939
109BCR0.71134811
110MAP3K50.70962960
111HCK0.69310707
112ERN10.68531935
113TAF10.67677632
114JAK20.67133225
115MAP2K10.66409306
116PAK20.66288161
117TNK20.63770307
118CDK30.63514241
119PASK0.62893365
120CLK10.62804589
121CHEK20.62604683
122LYN0.59839744
123LCK0.58167285
124RPS6KB20.57754860
125EPHB10.57193004
126BRSK20.55813104
127MET0.55310166
128AURKB0.54675018
129MAP3K80.54049201
130NME20.53807336
131MAPKAPK30.52202811
132WEE10.51022096
133FGFR10.50020692
134TNIK0.49957857
135STK100.49849602
136TTN0.49641126
137FER0.48917928
138IRAK10.47956569
139PDGFRA0.47875288
140PRKD20.47624737
141PTK20.47368181
142RPS6KA50.47283188
143TAOK30.46201321
144TGFBR10.46093853
145PLK10.45723080
146RPS6KB10.45159200
147CSK0.45067352
148ABL10.44717163
149PDGFRB0.44575279
150SGK20.43973729
151PRKCH0.43539142
152CSF1R0.43458946
153PRKAA20.43453902
154TLK10.43056875
155CDK70.41678339
156GRK60.39822507

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21833889
2Thyroid cancer_Homo sapiens_hsa052162.21759877
3Non-small cell lung cancer_Homo sapiens_hsa052232.17698726
4Pancreatic cancer_Homo sapiens_hsa052122.13349155
5Primary immunodeficiency_Homo sapiens_hsa053402.11956167
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.05062559
7DNA replication_Homo sapiens_hsa030301.94886963
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94876664
9Homologous recombination_Homo sapiens_hsa034401.81248713
10Fanconi anemia pathway_Homo sapiens_hsa034601.70618514
11Vitamin B6 metabolism_Homo sapiens_hsa007501.66758703
12Adherens junction_Homo sapiens_hsa045201.64779040
13Renal cell carcinoma_Homo sapiens_hsa052111.64025958
14Lysine degradation_Homo sapiens_hsa003101.63715535
15Measles_Homo sapiens_hsa051621.63555845
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53888217
17p53 signaling pathway_Homo sapiens_hsa041151.53485602
18Prostate cancer_Homo sapiens_hsa052151.53478250
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51136247
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48120718
21Mismatch repair_Homo sapiens_hsa034301.47528170
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.43674029
23Systemic lupus erythematosus_Homo sapiens_hsa053221.41130751
24VEGF signaling pathway_Homo sapiens_hsa043701.40156311
25Herpes simplex infection_Homo sapiens_hsa051681.38993726
26Focal adhesion_Homo sapiens_hsa045101.38658754
27Cell cycle_Homo sapiens_hsa041101.37109996
28One carbon pool by folate_Homo sapiens_hsa006701.37024836
29Sulfur relay system_Homo sapiens_hsa041221.35737558
30T cell receptor signaling pathway_Homo sapiens_hsa046601.33949398
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32026000
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29733651
33Proteoglycans in cancer_Homo sapiens_hsa052051.29641247
34Glioma_Homo sapiens_hsa052141.29600551
35Platelet activation_Homo sapiens_hsa046111.27368762
36Osteoclast differentiation_Homo sapiens_hsa043801.27338582
37B cell receptor signaling pathway_Homo sapiens_hsa046621.26281094
38Acute myeloid leukemia_Homo sapiens_hsa052211.22964459
39Small cell lung cancer_Homo sapiens_hsa052221.19425338
40Choline metabolism in cancer_Homo sapiens_hsa052311.17168072
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15674619
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15566255
43Arginine biosynthesis_Homo sapiens_hsa002201.14830004
44Insulin resistance_Homo sapiens_hsa049311.14019776
45Hepatitis B_Homo sapiens_hsa051611.13203185
46Staphylococcus aureus infection_Homo sapiens_hsa051501.13173043
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13131397
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12963647
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11680070
50Influenza A_Homo sapiens_hsa051641.09124438
51Leishmaniasis_Homo sapiens_hsa051401.08238935
52ErbB signaling pathway_Homo sapiens_hsa040121.07968457
53Amoebiasis_Homo sapiens_hsa051461.07161633
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.06748965
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05887177
56Dorso-ventral axis formation_Homo sapiens_hsa043201.04398327
57Chronic myeloid leukemia_Homo sapiens_hsa052201.02126190
58Antigen processing and presentation_Homo sapiens_hsa046121.01977448
59Regulation of autophagy_Homo sapiens_hsa041400.99425071
60HTLV-I infection_Homo sapiens_hsa051660.97917097
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95986598
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.95704142
63TNF signaling pathway_Homo sapiens_hsa046680.95450735
64ABC transporters_Homo sapiens_hsa020100.94952168
65Bladder cancer_Homo sapiens_hsa052190.94735305
66Spliceosome_Homo sapiens_hsa030400.94071036
67GnRH signaling pathway_Homo sapiens_hsa049120.93150917
68Hematopoietic cell lineage_Homo sapiens_hsa046400.92471440
69ECM-receptor interaction_Homo sapiens_hsa045120.92001704
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.90734952
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88512475
72Apoptosis_Homo sapiens_hsa042100.88268113
73Toxoplasmosis_Homo sapiens_hsa051450.87426807
74Base excision repair_Homo sapiens_hsa034100.87036345
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86511711
76Pyrimidine metabolism_Homo sapiens_hsa002400.85940924
77Fatty acid biosynthesis_Homo sapiens_hsa000610.85237189
78mRNA surveillance pathway_Homo sapiens_hsa030150.84916459
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.84087717
80FoxO signaling pathway_Homo sapiens_hsa040680.82700257
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81339679
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.80284632
83AMPK signaling pathway_Homo sapiens_hsa041520.78871169
84Epstein-Barr virus infection_Homo sapiens_hsa051690.78412032
85Estrogen signaling pathway_Homo sapiens_hsa049150.78351151
86mTOR signaling pathway_Homo sapiens_hsa041500.78322645
87Long-term potentiation_Homo sapiens_hsa047200.78308719
88Viral carcinogenesis_Homo sapiens_hsa052030.77955533
89Selenocompound metabolism_Homo sapiens_hsa004500.76512904
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76416224
91PPAR signaling pathway_Homo sapiens_hsa033200.76071885
92Vitamin digestion and absorption_Homo sapiens_hsa049770.75970263
93Pathways in cancer_Homo sapiens_hsa052000.73658923
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73617311
95Insulin signaling pathway_Homo sapiens_hsa049100.73057918
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71743697
97Type II diabetes mellitus_Homo sapiens_hsa049300.70055770
98Melanoma_Homo sapiens_hsa052180.68364895
99Hepatitis C_Homo sapiens_hsa051600.68235986
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67931684
101RNA transport_Homo sapiens_hsa030130.67142874
102TGF-beta signaling pathway_Homo sapiens_hsa043500.66709877
103Prolactin signaling pathway_Homo sapiens_hsa049170.65291623
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65201375
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64785423
106Purine metabolism_Homo sapiens_hsa002300.63793180
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63485551
108Colorectal cancer_Homo sapiens_hsa052100.61940971
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61829209
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60702174
111Complement and coagulation cascades_Homo sapiens_hsa046100.59648113
112Endometrial cancer_Homo sapiens_hsa052130.59387861
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56611582
114Fatty acid degradation_Homo sapiens_hsa000710.55281763
115beta-Alanine metabolism_Homo sapiens_hsa004100.54817845
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.54044463
117MicroRNAs in cancer_Homo sapiens_hsa052060.53404371
118Nucleotide excision repair_Homo sapiens_hsa034200.52812421
119Non-homologous end-joining_Homo sapiens_hsa034500.52745548
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52500724
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51933954
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51048518
123Notch signaling pathway_Homo sapiens_hsa043300.50765911
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50487122
125Chemokine signaling pathway_Homo sapiens_hsa040620.50274315
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49936582
127Long-term depression_Homo sapiens_hsa047300.49397142
128Endocytosis_Homo sapiens_hsa041440.49379362
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49036251
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.48661436
131Folate biosynthesis_Homo sapiens_hsa007900.48068860
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.47388775
133Inositol phosphate metabolism_Homo sapiens_hsa005620.47123982
134RNA degradation_Homo sapiens_hsa030180.46981435
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46393377
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46205274
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45921738
138HIF-1 signaling pathway_Homo sapiens_hsa040660.45609860
139Rap1 signaling pathway_Homo sapiens_hsa040150.45554126
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44302944
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44128118
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.43686753
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.43430941
144Viral myocarditis_Homo sapiens_hsa054160.41981956
145Glucagon signaling pathway_Homo sapiens_hsa049220.41874843
146Hippo signaling pathway_Homo sapiens_hsa043900.41666999
147Prion diseases_Homo sapiens_hsa050200.41353237
148MAPK signaling pathway_Homo sapiens_hsa040100.40524709
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40172798

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