FBXW4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80642848
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17540743
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17540743
4regulation of female gonad development (GO:2000194)3.82768993
5histone H2A monoubiquitination (GO:0035518)3.78007133
6positive regulation of histone deacetylation (GO:0031065)3.68264942
7antigen processing and presentation via MHC class Ib (GO:0002475)3.67426699
8regulation of histone H3-K27 methylation (GO:0061085)3.62723089
9regulation of RIG-I signaling pathway (GO:0039535)3.51346960
10megakaryocyte development (GO:0035855)3.49976710
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.38225461
12DNA damage response, signal transduction resulting in transcription (GO:0042772)3.35808662
13negative regulation of erythrocyte differentiation (GO:0045647)3.33174247
14antigen processing and presentation of endogenous antigen (GO:0019883)3.30702883
15regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.29593749
163-UTR-mediated mRNA stabilization (GO:0070935)3.24796656
17attachment of spindle microtubules to kinetochore (GO:0008608)3.18148345
18regulation of histone phosphorylation (GO:0033127)3.14042984
19histone H2A ubiquitination (GO:0033522)3.07846493
20positive regulation of B cell differentiation (GO:0045579)3.07358660
21regulation of sister chromatid cohesion (GO:0007063)3.05200273
22protein localization to kinetochore (GO:0034501)3.05164337
23mannose metabolic process (GO:0006013)3.00011364
24carnitine shuttle (GO:0006853)2.99132069
25positive regulation of granulocyte differentiation (GO:0030854)2.96862760
26sulfur amino acid catabolic process (GO:0000098)2.96678358
27lysine metabolic process (GO:0006553)2.92305485
28lysine catabolic process (GO:0006554)2.92305485
29fatty acid transmembrane transport (GO:1902001)2.89240790
30regulation of meiosis (GO:0040020)2.89175070
31citrulline biosynthetic process (GO:0019240)2.85358048
32mitotic chromosome condensation (GO:0007076)2.83809664
33urea cycle (GO:0000050)2.82714615
34urea metabolic process (GO:0019627)2.82714615
35positive regulation of megakaryocyte differentiation (GO:0045654)2.82452659
36regulation of early endosome to late endosome transport (GO:2000641)2.81743607
37positive regulation of gamma-delta T cell activation (GO:0046645)2.81476338
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.79350808
39negative regulation of cell size (GO:0045792)2.75875527
40regulation of granulocyte differentiation (GO:0030852)2.75240608
41female gamete generation (GO:0007292)2.75020484
42negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.73062327
43regulation of sequestering of triglyceride (GO:0010889)2.72543874
44valine metabolic process (GO:0006573)2.71958317
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70321404
46angiogenesis involved in wound healing (GO:0060055)2.69895361
47regulation of Rap GTPase activity (GO:0032317)2.69401350
48positive regulation of protein deacetylation (GO:0090312)2.68664212
49negative regulation of necroptotic process (GO:0060546)2.67757751
50diacylglycerol metabolic process (GO:0046339)2.67443936
51mitotic G1 DNA damage checkpoint (GO:0031571)2.66272886
52detection of calcium ion (GO:0005513)2.66126113
53regulation of gamma-delta T cell differentiation (GO:0045586)2.65708632
54DNA damage induced protein phosphorylation (GO:0006975)2.65279977
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64741306
56glycerophospholipid catabolic process (GO:0046475)2.64154985
57negative regulation of execution phase of apoptosis (GO:1900118)2.63452062
58phosphatidylinositol dephosphorylation (GO:0046856)2.62325869
59phospholipid dephosphorylation (GO:0046839)2.61709762
60negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.60715914
61myelin maintenance (GO:0043217)2.60544350
62creatine metabolic process (GO:0006600)2.59882685
63immunoglobulin mediated immune response (GO:0016064)2.58420986
64regulation of fatty acid oxidation (GO:0046320)2.58371014
65protein localization to chromosome, centromeric region (GO:0071459)2.57801188
66alpha-linolenic acid metabolic process (GO:0036109)2.57489393
67folic acid-containing compound biosynthetic process (GO:0009396)2.56121650
68epithelial cell fate commitment (GO:0072148)2.55527410
69cardiac myofibril assembly (GO:0055003)2.55111971
70type B pancreatic cell development (GO:0003323)2.54411073
71T cell migration (GO:0072678)2.52348009
72nitrogen cycle metabolic process (GO:0071941)2.51611254
73regulation of necroptotic process (GO:0060544)2.50786644
74maturation of 5.8S rRNA (GO:0000460)2.50134596
75T cell apoptotic process (GO:0070231)2.49702118
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.49677944
772-oxoglutarate metabolic process (GO:0006103)2.47965423
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47489043
79potassium ion import (GO:0010107)2.46329050
80positive thymic T cell selection (GO:0045059)2.45632069
81negative regulation of hormone metabolic process (GO:0032351)2.45292910
82negative regulation of hormone biosynthetic process (GO:0032353)2.45292910
83regulation of exit from mitosis (GO:0007096)2.45131261
84positive regulation of triglyceride biosynthetic process (GO:0010867)2.43495511
85NADH metabolic process (GO:0006734)2.43224876
86regulation of B cell differentiation (GO:0045577)2.42979331
87positive regulation of fatty acid oxidation (GO:0046321)2.42402266
88intracellular estrogen receptor signaling pathway (GO:0030520)2.41874595
89regulation of glucocorticoid metabolic process (GO:0031943)2.41776992
90positive regulation of sodium ion transport (GO:0010765)2.41563233
91regulation of extracellular matrix disassembly (GO:0010715)2.41515953
92negative regulation of granulocyte differentiation (GO:0030853)2.41400940
93positive regulation of Rap GTPase activity (GO:0032854)2.40682108
94inositol phosphate catabolic process (GO:0071545)2.40413027
95inositol phosphate dephosphorylation (GO:0046855)2.39809002
96phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39809002
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39643978
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39640292
99negative regulation of cell killing (GO:0031342)2.39640292
100protein-lipid complex assembly (GO:0065005)2.38937531
101regulation of integrin activation (GO:0033623)2.38236072
102positive regulation of lamellipodium assembly (GO:0010592)2.37726957
103regulation of fatty acid beta-oxidation (GO:0031998)2.37685991
104macroautophagy (GO:0016236)2.37158834
105negative regulation of meiosis (GO:0045835)2.36272430
106maternal placenta development (GO:0001893)2.35461360
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34413549
108fat-soluble vitamin biosynthetic process (GO:0042362)2.32969896
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.32898107
110cardiac muscle adaptation (GO:0014887)2.31997077
111cardiac muscle hypertrophy in response to stress (GO:0014898)2.31997077
112muscle hypertrophy in response to stress (GO:0003299)2.31997077
113mRNA stabilization (GO:0048255)2.31829840
114RNA stabilization (GO:0043489)2.31829840
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31535831
116cardiac muscle hypertrophy (GO:0003300)2.29731941
117phenol-containing compound catabolic process (GO:0019336)2.29245501
118glandular epithelial cell development (GO:0002068)2.28650073
119one-carbon metabolic process (GO:0006730)2.28587439
120regulation of erythrocyte differentiation (GO:0045646)2.28440219
121heme biosynthetic process (GO:0006783)2.28412574
122protein localization to endosome (GO:0036010)2.27782118
123oocyte maturation (GO:0001556)2.27140003
124NIK/NF-kappaB signaling (GO:0038061)2.27063661
125positive regulation of protein dephosphorylation (GO:0035307)2.26111025
126mast cell activation involved in immune response (GO:0002279)2.25947441
127mast cell degranulation (GO:0043303)2.25947441
128regulation of ARF protein signal transduction (GO:0032012)2.25665921
129L-alpha-amino acid transmembrane transport (GO:1902475)2.24504551
130pathway-restricted SMAD protein phosphorylation (GO:0060389)2.24275315
131regulation of proton transport (GO:0010155)2.24225110
132positive regulation of lamellipodium organization (GO:1902745)2.24129326
133regulation of cholesterol storage (GO:0010885)2.23700306
134L-phenylalanine metabolic process (GO:0006558)2.23299617
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.23299617
136positive regulation of protein homooligomerization (GO:0032464)2.23133948
137growth hormone receptor signaling pathway (GO:0060396)2.22733646
138dendritic spine morphogenesis (GO:0060997)2.21075017
139regulation of protein glycosylation (GO:0060049)2.20819356
140skeletal muscle contraction (GO:0003009)2.19436927
141striated muscle contraction (GO:0006941)2.17919891
142myofibril assembly (GO:0030239)2.17825549
143nitric oxide mediated signal transduction (GO:0007263)2.17752743
144muscle hypertrophy (GO:0014896)2.17698268
145striated muscle hypertrophy (GO:0014897)2.17170246
146positive regulation of gluconeogenesis (GO:0045722)2.15083702
147regulation of glycogen (starch) synthase activity (GO:2000465)2.14328340
148response to acidic pH (GO:0010447)2.13621738
149cardiac muscle contraction (GO:0060048)2.10853341
150regulation of sodium ion transport (GO:0002028)2.10694233
151regulation of the force of heart contraction (GO:0002026)2.09221426
152regulation of sodium ion transmembrane transport (GO:1902305)2.08629358
153negative regulation of cAMP-mediated signaling (GO:0043951)2.07989439
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.07133074
155striated muscle adaptation (GO:0014888)2.06216421
156regulation of skeletal muscle contraction (GO:0014819)2.04744543
157cardiac conduction (GO:0061337)2.04123064
158regulation of sodium ion transmembrane transporter activity (GO:2000649)2.02963410
159actin-myosin filament sliding (GO:0033275)2.02519801
160muscle filament sliding (GO:0030049)2.02519801
161thymic T cell selection (GO:0045061)2.01343096
162positive regulation of glycogen biosynthetic process (GO:0045725)2.01006440
163long term synaptic depression (GO:0060292)1.99887352
164negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.99004471
165positive regulation of digestive system process (GO:0060456)1.98715560
166peptidyl-tyrosine autophosphorylation (GO:0038083)1.98426975
167positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.98383503
168regulation of gamma-delta T cell activation (GO:0046643)1.97690978
169positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.97046773
170negative regulation of protein kinase B signaling (GO:0051898)1.96940970
171one-carbon compound transport (GO:0019755)1.96831617
172dicarboxylic acid biosynthetic process (GO:0043650)1.96743537
173positive T cell selection (GO:0043368)1.96038885
174positive regulation of sodium ion transmembrane transport (GO:1902307)1.95508179
175glycogen catabolic process (GO:0005980)1.95019132
176skeletal muscle adaptation (GO:0043501)1.94506112
177activation of MAPKKK activity (GO:0000185)1.93289209
178regulation of cholesterol metabolic process (GO:0090181)1.92518816
179positive regulation of synapse maturation (GO:0090129)1.89785888
180regulation of actin filament-based movement (GO:1903115)1.89699772
181sarcoplasmic reticulum calcium ion transport (GO:0070296)1.89582342
182cellular ketone body metabolic process (GO:0046950)1.89298450
183positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003571.89216116
184regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.88166804
185regulation of ARF GTPase activity (GO:0032312)1.87911458
186amino-acid betaine transport (GO:0015838)1.86955499
187carnitine transport (GO:0015879)1.86955499
188cellular potassium ion homeostasis (GO:0030007)1.86364075
189positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.86078205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.40179257
2MYC_22102868_ChIP-Seq_BL_Human3.29193752
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.14658787
4SCL_19346495_ChIP-Seq_HPC-7_Human2.89144849
5VDR_21846776_ChIP-Seq_THP-1_Human2.85480441
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77699472
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76038527
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.64918812
9TCF7_22412390_ChIP-Seq_EML_Mouse2.63198107
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.46013232
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45068834
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25191844
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20973194
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16883323
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.12373476
16DROSHA_22980978_ChIP-Seq_HELA_Human2.11689272
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10872059
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09183582
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06560704
20EZH2_22144423_ChIP-Seq_EOC_Human2.06023181
21* KDM2B_26808549_Chip-Seq_DND41_Human2.03035921
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01975746
23* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98253222
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95286347
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93078248
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89911706
27UTX_26944678_Chip-Seq_JUKART_Human1.89113867
28VDR_24763502_ChIP-Seq_THP-1_Human1.85841638
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.84988144
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84455952
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84057980
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.82114553
33MAF_26560356_Chip-Seq_TH1_Human1.81206768
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75748247
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72170870
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68847548
37* LXR_22158963_ChIP-Seq_LIVER_Mouse1.68643350
38E2F7_22180533_ChIP-Seq_HELA_Human1.68089045
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.67379745
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67260792
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.66464235
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.65060373
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63946517
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60146190
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59745769
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.57073979
47CTCF_27219007_Chip-Seq_Bcells_Human1.56449775
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55891404
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55415833
50LXR_22292898_ChIP-Seq_THP-1_Human1.50324619
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48197319
52* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48090557
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47148708
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46724935
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45928415
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45771631
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44976945
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.44645632
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44382745
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44195280
61MAF_26560356_Chip-Seq_TH2_Human1.44127667
62ZNF263_19887448_ChIP-Seq_K562_Human1.43800768
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43307226
64SPI1_23127762_ChIP-Seq_K562_Human1.43164523
65SMC4_20622854_ChIP-Seq_HELA_Human1.42677919
66MYB_26560356_Chip-Seq_TH1_Human1.41854409
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38467656
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.38313698
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37403619
70MYB_26560356_Chip-Seq_TH2_Human1.36343865
71RACK7_27058665_Chip-Seq_MCF-7_Human1.34371611
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.33900490
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33859568
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33078764
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.32518067
76ATF3_27146783_Chip-Seq_COLON_Human1.31891665
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31245206
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30235592
79* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30151868
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29808759
81* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29094419
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27395158
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27340933
84SPI1_20517297_ChIP-Seq_HL60_Human1.27315026
85GATA1_19941826_ChIP-Seq_K562_Human1.25643905
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25624301
87CTCF_21964334_Chip-Seq_Bcells_Human1.22571378
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22021127
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21650201
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20456340
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.19203575
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.17551381
93* P68_20966046_ChIP-Seq_HELA_Human1.17531903
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16329217
95BCL6_27268052_Chip-Seq_Bcells_Human1.15197403
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15016602
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14818298
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13882776
99SA1_27219007_Chip-Seq_Bcells_Human1.13720343
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13436850
101TP63_22573176_ChIP-Seq_HFKS_Human1.13115449
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12397133
103* SPI1_23547873_ChIP-Seq_NB4_Human1.11371049
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11364230
105OCT4_19829295_ChIP-Seq_ESCs_Human1.09810294
106* RNF2_27304074_Chip-Seq_ESCs_Mouse1.09158073
107RUNX_20019798_ChIP-Seq_JUKART_Human1.09131117
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09117543
109KDM2B_26808549_Chip-Seq_K562_Human1.07953991
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07913028
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06978161
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06576571
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06045964
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.05274640
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04098628
116BCOR_27268052_Chip-Seq_Bcells_Human1.03592653
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02876207
118* CREB1_26743006_Chip-Seq_LNCaP_Human1.02495694
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.02428795
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.02223473
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01859504
122GATA2_19941826_ChIP-Seq_K562_Human1.01224629
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.97762452
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.97762452
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97635137
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96942356
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.96102554
128GATA3_27048872_Chip-Seq_THYMUS_Human0.95794877
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.95779220
130REST_21632747_ChIP-Seq_MESCs_Mouse0.95675882
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95616957
132KLF4_19829295_ChIP-Seq_ESCs_Human0.95393308
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.94956506
134NCOR1_26117541_ChIP-Seq_K562_Human0.94751904
135EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94345723
136GATA1_22025678_ChIP-Seq_K562_Human0.93049674
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.92896343
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92606330
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92526813
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92473218
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92097445
142* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91519821
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.91489130
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90798461
145* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90709472
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90630935
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89981858
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89727591
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89220731
150SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89006722
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86555664
152EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86096084
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86096084
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85908042
155SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85460435
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85375411
157CTCF_20526341_ChIP-Seq_ESCs_Human0.85279133
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85264182
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85250419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.61216510
2MP0002396_abnormal_hematopoietic_system3.17362636
3MP0005451_abnormal_body_composition3.13361471
4MP0010234_abnormal_vibrissa_follicle3.08229222
5MP0003656_abnormal_erythrocyte_physiolo2.75005161
6MP0002254_reproductive_system_inflammat2.51821086
7MP0009840_abnormal_foam_cell2.49858453
8MP0004185_abnormal_adipocyte_glucose2.32862710
9MP0003705_abnormal_hypodermis_morpholog2.30683798
10MP0003191_abnormal_cellular_cholesterol2.24627370
11MP0004043_abnormal_pH_regulation2.24237478
12MP0009780_abnormal_chondrocyte_physiolo2.24189003
13MP0002139_abnormal_hepatobiliary_system2.18962971
14MP0000566_synostosis2.18613538
15MP0005360_urolithiasis2.16178523
16MP0005464_abnormal_platelet_physiology2.11213517
17MP0002876_abnormal_thyroid_physiology2.09544680
18MP0001501_abnormal_sleep_pattern2.06718353
19MP0004130_abnormal_muscle_cell1.96215198
20MP0004510_myositis1.94152534
21MP0003303_peritoneal_inflammation1.93577673
22MP0003045_fibrosis1.93411679
23MP0010368_abnormal_lymphatic_system1.89278623
24MP0005365_abnormal_bile_salt1.79378009
25MP0005085_abnormal_gallbladder_physiolo1.74227749
26MP0000685_abnormal_immune_system1.71883379
27MP0003879_abnormal_hair_cell1.70236313
28MP0005397_hematopoietic_system_phenotyp1.69324217
29MP0001545_abnormal_hematopoietic_system1.69324217
30MP0003787_abnormal_imprinting1.66586680
31MP0002909_abnormal_adrenal_gland1.66580752
32MP0002877_abnormal_melanocyte_morpholog1.64542747
33MP0002653_abnormal_ependyma_morphology1.63380006
34MP0000343_altered_response_to1.61420253
35MP0005058_abnormal_lysosome_morphology1.60534744
36MP0002933_joint_inflammation1.58992368
37MP0003690_abnormal_glial_cell1.55895710
38MP0005535_abnormal_body_temperature1.54008441
39MP0003300_gastrointestinal_ulcer1.53659736
40MP0003763_abnormal_thymus_physiology1.52700184
41MP0002837_dystrophic_cardiac_calcinosis1.52651832
42MP0009278_abnormal_bone_marrow1.51830087
43MP0005666_abnormal_adipose_tissue1.50445404
44MP0005167_abnormal_blood-brain_barrier1.46498214
45MP0004087_abnormal_muscle_fiber1.46383473
46MP0000013_abnormal_adipose_tissue1.44524293
47MP0004145_abnormal_muscle_electrophysio1.44023345
48MP0003436_decreased_susceptibility_to1.41521818
49MP0001502_abnormal_circadian_rhythm1.41422326
50MP0002398_abnormal_bone_marrow1.39035248
51MP0000609_abnormal_liver_physiology1.37881273
52MP0000465_gastrointestinal_hemorrhage1.37776217
53MP0003252_abnormal_bile_duct1.35964484
54MP0000689_abnormal_spleen_morphology1.35305424
55MP0002269_muscular_atrophy1.33646122
56MP0000490_abnormal_crypts_of1.33549402
57MP0000751_myopathy1.31851465
58MP0010386_abnormal_urinary_bladder1.31081254
59MP0009333_abnormal_splenocyte_physiolog1.28312453
60MP0002064_seizures1.27217094
61MP0010329_abnormal_lipoprotein_level1.27033889
62MP0000749_muscle_degeneration1.26956623
63MP0004036_abnormal_muscle_relaxation1.26450072
64MP0001800_abnormal_humoral_immune1.24555206
65MP0005423_abnormal_somatic_nervous1.20905239
66MP0003111_abnormal_nucleus_morphology1.20678212
67MP0001835_abnormal_antigen_presentation1.20414894
68MP0002078_abnormal_glucose_homeostasis1.19138401
69MP0003880_abnormal_central_pattern1.18773880
70MP0000003_abnormal_adipose_tissue1.18399195
71MP0001915_intracranial_hemorrhage1.18045435
72MP0004270_analgesia1.18044750
73MP0002405_respiratory_system_inflammati1.16424174
74MP0003077_abnormal_cell_cycle1.15111338
75MP0010352_gastrointestinal_tract_polyps1.14812041
76MP0002693_abnormal_pancreas_physiology1.14457548
77MP0003699_abnormal_female_reproductive1.13693641
78MP0005310_abnormal_salivary_gland1.13553595
79MP0004084_abnormal_cardiac_muscle1.11567720
80MP0004484_altered_response_of1.11494542
81MP0002106_abnormal_muscle_physiology1.11432201
82MP0002722_abnormal_immune_system1.11024427
83MP0002019_abnormal_tumor_incidence1.10182432
84MP0009745_abnormal_behavioral_response1.09738287
85MP0010630_abnormal_cardiac_muscle1.09305226
86MP0002971_abnormal_brown_adipose1.09024751
87MP0003718_maternal_effect1.08978387
88MP0003172_abnormal_lysosome_physiology1.08795676
89MP0001944_abnormal_pancreas_morphology1.07894001
90MP0001661_extended_life_span1.07843143
91MP0004859_abnormal_synaptic_plasticity1.06526793
92MP0000716_abnormal_immune_system1.06487447
93MP0009643_abnormal_urine_homeostasis1.06351438
94MP0005670_abnormal_white_adipose1.05946336
95MP0005645_abnormal_hypothalamus_physiol1.05899679
96MP0002429_abnormal_blood_cell1.05069426
97MP0002452_abnormal_antigen_presenting1.05050899
98MP0002420_abnormal_adaptive_immunity1.03298836
99MP0004808_abnormal_hematopoietic_stem1.01946584
100MP0008569_lethality_at_weaning1.01123836
101MP0002419_abnormal_innate_immunity1.01031748
102MP0010094_abnormal_chromosome_stability1.00901892
103MP0001819_abnormal_immune_cell1.00642640
104MP0005330_cardiomyopathy0.99580973
105MP0005448_abnormal_energy_balance0.99364251
106MP0000703_abnormal_thymus_morphology0.98778768
107MP0002970_abnormal_white_adipose0.98755707
108MP0009115_abnormal_fat_cell0.98585730
109MP0002723_abnormal_immune_serum0.97942057
110MP0003221_abnormal_cardiomyocyte_apopto0.97853327
111MP0005379_endocrine/exocrine_gland_phen0.97667227
112MP0000598_abnormal_liver_morphology0.97635611
113MP0000639_abnormal_adrenal_gland0.97352541
114MP0001765_abnormal_ion_homeostasis0.97141837
115MP0005369_muscle_phenotype0.96841145
116MP0005000_abnormal_immune_tolerance0.96830006
117MP0000759_abnormal_skeletal_muscle0.96552860
118MP0000538_abnormal_urinary_bladder0.96519226
119MP0005025_abnormal_response_to0.96063159
120MP0005671_abnormal_response_to0.94557593
121MP0006036_abnormal_mitochondrial_physio0.94507389
122MP0001119_abnormal_female_reproductive0.94208279
123MP0005620_abnormal_muscle_contractility0.92917975
124MP0002108_abnormal_muscle_morphology0.92757973
125MP0002063_abnormal_learning/memory/cond0.92559866
126MP0005166_decreased_susceptibility_to0.92015678
127MP0003329_amyloid_beta_deposits0.91817770
128MP0005387_immune_system_phenotype0.91610071
129MP0001790_abnormal_immune_system0.91610071
130MP0008961_abnormal_basal_metabolism0.91247643
131MP0000733_abnormal_muscle_development0.87379893
132MP0005083_abnormal_biliary_tract0.87378337
133MP0005375_adipose_tissue_phenotype0.86783184
134MP0010155_abnormal_intestine_physiology0.86395185
135MP0003633_abnormal_nervous_system0.85566884
136MP0003075_altered_response_to0.85210356
137MP0009763_increased_sensitivity_to0.84974804
138MP0000920_abnormal_myelination0.84782141
139MP0001845_abnormal_inflammatory_respons0.83828169
140MP0002272_abnormal_nervous_system0.83706833
141MP0003635_abnormal_synaptic_transmissio0.83464602
142MP0000230_abnormal_systemic_arterial0.82177351
143MP0001905_abnormal_dopamine_level0.81859231
144MP0005332_abnormal_amino_acid0.81756423
145MP0002118_abnormal_lipid_homeostasis0.81686763
146MP0006082_CNS_inflammation0.81569766
147MP0003011_delayed_dark_adaptation0.81250355
148MP0005319_abnormal_enzyme/_coenzyme0.81151191
149MP0001756_abnormal_urination0.79329384
150MP0001958_emphysema0.79005533
151MP0004019_abnormal_vitamin_homeostasis0.78839363
152MP0002166_altered_tumor_susceptibility0.77975716
153MP0002972_abnormal_cardiac_muscle0.77570808
154MP0000747_muscle_weakness0.77439149
155MP0008469_abnormal_protein_level0.75175025
156MP0003693_abnormal_embryo_hatching0.74809954
157MP0001968_abnormal_touch/_nociception0.74277525
158MP0003137_abnormal_impulse_conducting0.74236651
159MP0001873_stomach_inflammation0.74142441
160MP0006138_congestive_heart_failure0.73228816
161MP0004885_abnormal_endolymph0.73137787
162MP0005646_abnormal_pituitary_gland0.73057224
163MP0002572_abnormal_emotion/affect_behav0.73004451
164MP0002168_other_aberrant_phenotype0.72371375

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)4.95310828
2Deep venous thrombosis (HP:0002625)3.60401286
3Hyporeflexia of lower limbs (HP:0002600)3.56956606
4Abnormal gallbladder physiology (HP:0012438)3.56329337
5Cholecystitis (HP:0001082)3.56329337
6Obstructive sleep apnea (HP:0002870)3.50274024
7Asymmetric septal hypertrophy (HP:0001670)3.25482249
8Muscle fiber splitting (HP:0003555)3.17343095
9Prolonged bleeding time (HP:0003010)3.09437955
10Urinary glycosaminoglycan excretion (HP:0003541)3.00627317
11Mucopolysacchariduria (HP:0008155)3.00627317
12Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.98728283
13Abnormal delayed hypersensitivity skin test (HP:0002963)2.89357376
14Spondylolisthesis (HP:0003302)2.78243683
15Dysostosis multiplex (HP:0000943)2.76307489
16J-shaped sella turcica (HP:0002680)2.73068120
17Lymphangioma (HP:0100764)2.72288639
18Abnormality of the left ventricular outflow tract (HP:0011103)2.71738225
19Subaortic stenosis (HP:0001682)2.71738225
20Increased CSF protein (HP:0002922)2.70594167
21Elevated erythrocyte sedimentation rate (HP:0003565)2.69213289
22Recurrent abscess formation (HP:0002722)2.68933989
23Colitis (HP:0002583)2.67102850
24Myositis (HP:0100614)2.66155717
25Complement deficiency (HP:0004431)2.65195640
26Testicular neoplasm (HP:0010788)2.64720587
27Hypochromic microcytic anemia (HP:0004840)2.64050782
28Cholelithiasis (HP:0001081)2.60890294
29Ventricular fibrillation (HP:0001663)2.60747904
30Type 1 muscle fiber predominance (HP:0003803)2.60510760
31Abnormality of the Achilles tendon (HP:0005109)2.56429909
32Abnormal atrioventricular conduction (HP:0005150)2.55281792
33Polycythemia (HP:0001901)2.54186804
34Bundle branch block (HP:0011710)2.50891177
35Hamartoma of the eye (HP:0010568)2.49506577
36Achilles tendon contracture (HP:0001771)2.49335756
37Myopathic facies (HP:0002058)2.48426782
38Increased variability in muscle fiber diameter (HP:0003557)2.47378404
39Impaired platelet aggregation (HP:0003540)2.47331427
40Abnormal platelet function (HP:0011869)2.47331427
41Ventricular tachycardia (HP:0004756)2.46960781
42Recurrent gram-negative bacterial infections (HP:0005420)2.46484642
43Hyperthyroidism (HP:0000836)2.44207536
44Myoglobinuria (HP:0002913)2.43903586
45Muscle fiber inclusion bodies (HP:0100299)2.43681503
46Hypochromic anemia (HP:0001931)2.41603218
47Late onset (HP:0003584)2.40703117
48Ventricular arrhythmia (HP:0004308)2.40336458
49Conjunctival hamartoma (HP:0100780)2.39877320
50Exercise-induced muscle cramps (HP:0003710)2.38663547
51Viral hepatitis (HP:0006562)2.38379485
52Prolonged QT interval (HP:0001657)2.38007231
53Distal lower limb muscle weakness (HP:0009053)2.37480265
54Abnormal EKG (HP:0003115)2.34483706
55EMG: myopathic abnormalities (HP:0003458)2.34423761
56Exercise-induced myalgia (HP:0003738)2.34101900
57Myocardial infarction (HP:0001658)2.32907508
58Thrombocytosis (HP:0001894)2.31904587
59Nemaline bodies (HP:0003798)2.31057734
60Stomatitis (HP:0010280)2.30247805
61Enlarged penis (HP:0000040)2.28483043
62Microcytic anemia (HP:0001935)2.28080463
63Spontaneous hematomas (HP:0007420)2.27447076
64Stridor (HP:0010307)2.27070102
65Abnormality of skeletal muscle fiber size (HP:0012084)2.25633150
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24531340
67Myotonia (HP:0002486)2.23860578
68Ankle clonus (HP:0011448)2.23632096
69Subacute progressive viral hepatitis (HP:0006572)2.23561247
70Hyperlipoproteinemia (HP:0010980)2.22103133
71Abnormal gallbladder morphology (HP:0012437)2.21178022
72Panhypogammaglobulinemia (HP:0003139)2.20839930
73Hyperglycemia (HP:0003074)2.17500313
74Muscle hypertrophy of the lower extremities (HP:0008968)2.16982563
75Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15935116
76Easy fatigability (HP:0003388)2.15923959
77Syncope (HP:0001279)2.15898176
78Hematochezia (HP:0002573)2.14580083
79Round ear (HP:0100830)2.14045407
80Gastrointestinal inflammation (HP:0004386)2.13743498
81IgM deficiency (HP:0002850)2.13654636
82Abnormality of the fingertips (HP:0001211)2.13543780
83Epistaxis (HP:0000421)2.11498540
84Akinesia (HP:0002304)2.10837940
85Ketosis (HP:0001946)2.10001673
86Fetal akinesia sequence (HP:0001989)2.08680813
87Hypercortisolism (HP:0001578)2.08666815
88Inflammation of the large intestine (HP:0002037)2.08585763
89Nasal polyposis (HP:0100582)2.08054604
90Abnormality of T cell physiology (HP:0011840)2.06779020
91Cellulitis (HP:0100658)2.06628350
92Depressed nasal tip (HP:0000437)2.06015906
93Reticulocytosis (HP:0001923)2.05986755
94Atrioventricular block (HP:0001678)2.05302292
95Bone cyst (HP:0012062)2.05296836
96Abnormality of polysaccharide metabolism (HP:0011012)2.05103945
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05103945
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05103945
99Increased serum ferritin (HP:0003281)2.04840625
100Cerebral aneurysm (HP:0004944)2.04556050
101Abnormality of the nasal mucosa (HP:0000433)2.04483485
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04357453
103Frequent falls (HP:0002359)2.04278779
104Insulin-resistant diabetes mellitus (HP:0000831)2.03378722
105Abnormality of binocular vision (HP:0011514)2.03065924
106Diplopia (HP:0000651)2.03065924
107Abnormality of complement system (HP:0005339)2.02375494
108Recurrent bacterial skin infections (HP:0005406)2.00596842
109Oligomenorrhea (HP:0000876)2.00199119
110Febrile seizures (HP:0002373)1.98726911
111Acute myeloid leukemia (HP:0004808)1.98212874
112Abnormality of iron homeostasis (HP:0011031)1.96853448
113Arterial tortuosity (HP:0005116)1.95768979
114Axonal loss (HP:0003447)1.95363017
115Fatigue (HP:0012378)1.94966717
116Pustule (HP:0200039)1.93970216
117Ketoacidosis (HP:0001993)1.93635286
118Chest pain (HP:0100749)1.92428061
119Difficulty running (HP:0009046)1.91988018
120Macroorchidism (HP:0000053)1.91433680
121Malnutrition (HP:0004395)1.91296415
122Hyperammonemia (HP:0001987)1.91295667
123Albinism (HP:0001022)1.90279140
124Muscle fiber atrophy (HP:0100295)1.89414634
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89216444
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.86435454
127Bulbar palsy (HP:0001283)1.86379075
128Aplastic anemia (HP:0001915)1.85489867
129Type 2 muscle fiber atrophy (HP:0003554)1.84353598
130Hyperphosphatemia (HP:0002905)1.83635477
131Hyperkalemia (HP:0002153)1.83128667
132Lip pit (HP:0100267)1.82859280
133Hepatocellular carcinoma (HP:0001402)1.81873442
134Visceral angiomatosis (HP:0100761)1.81379168
135Systemic lupus erythematosus (HP:0002725)1.81370171
136Lipoatrophy (HP:0100578)1.80958346
137Xanthomatosis (HP:0000991)1.80620957
138Rhabdomyolysis (HP:0003201)1.80498157
139Popliteal pterygium (HP:0009756)1.80123049
140Camptodactyly of toe (HP:0001836)1.80070894
141Ulnar deviation of the wrist (HP:0003049)1.79452368
142Neck muscle weakness (HP:0000467)1.79224942
143Hyperbilirubinemia (HP:0002904)1.79180060
144Acanthosis nigricans (HP:0000956)1.78988221
145Abnormality of the common coagulation pathway (HP:0010990)1.78838216
146Abnormal platelet volume (HP:0011876)1.78813858
147Poikilocytosis (HP:0004447)1.78717048
148Polar cataract (HP:0010696)1.78715035
149Intention tremor (HP:0002080)1.78682320
150Abnormality of the calf musculature (HP:0001430)1.78557753
151Sudden death (HP:0001699)1.78372819
152Large for gestational age (HP:0001520)1.78073490
153Supranuclear gaze palsy (HP:0000605)1.76816574
154EMG: neuropathic changes (HP:0003445)1.76693670
155Recurrent viral infections (HP:0004429)1.76494597
156Mesangial abnormality (HP:0001966)1.76324170
157Heart block (HP:0012722)1.74998560
158Recurrent skin infections (HP:0001581)1.74477121
159Calf muscle hypertrophy (HP:0008981)1.74133145
160Growth hormone excess (HP:0000845)1.73914397
161Hypoalphalipoproteinemia (HP:0003233)1.73689936
162Genu recurvatum (HP:0002816)1.73539295
163Sensorimotor neuropathy (HP:0007141)1.73506836
164Acne (HP:0001061)1.73158939
165Nonprogressive disorder (HP:0003680)1.72523633
166Peritonitis (HP:0002586)1.72151947
167Joint hemorrhage (HP:0005261)1.72019915
168Sudden cardiac death (HP:0001645)1.71723971
169Urethral obstruction (HP:0000796)1.70647876
170Lower limb asymmetry (HP:0100559)1.70316598
171Gastrointestinal stroma tumor (HP:0100723)1.69092631
172Abnormality of calcium-phosphate metabolism (HP:0100530)1.67882897
173Broad face (HP:0000283)1.65555093
174Eczematoid dermatitis (HP:0000976)1.64952453
175Papilledema (HP:0001085)1.64594644
176Emphysema (HP:0002097)1.63953898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.44631757
2MAP3K63.56919681
3TRIB33.56469958
4FRK3.52040135
5FGFR22.97063715
6PKN22.69773935
7TAOK32.67083530
8KSR22.58295185
9MUSK2.57373851
10MAP3K102.53003641
11LATS12.43661816
12NTRK32.38247319
13BCKDK2.37910021
14TNK22.29329272
15MAP4K12.21854009
16FLT32.20559494
17MAPKAPK32.16699497
18PHKG22.13624626
19PHKG12.13624626
20KIT2.11774903
21ICK1.95309331
22MOS1.91062456
23MAP3K131.88263541
24ERN11.83991836
25LATS21.81744736
26MAP3K21.78934146
27TAOK11.71192248
28DAPK21.63853724
29FGFR31.61760206
30RAF11.55492392
31CDK81.54507358
32TTN1.50978654
33DMPK1.48508381
34MAP2K61.44219185
35CSF1R1.43766292
36PRPF4B1.43442467
37TYK21.40958803
38PRKCH1.39370225
39MAP3K91.37245714
40STK241.29881564
41MAP3K31.28210880
42CAMK11.25489838
43JAK31.22746335
44EPHA41.19854495
45STK101.14923728
46MAPK111.13490294
47ERBB41.13388572
48PINK11.04150186
49STK111.01491045
50RET1.00877879
51RPS6KB21.00496788
52TRPM71.00007258
53CAMK40.98796414
54TXK0.98579566
55MAP3K70.97088702
56CDK90.96459885
57MAP3K10.95285335
58SGK20.94905207
59CAMKK10.93931506
60CDC42BPA0.90636200
61PDPK10.89978814
62GRK60.87901465
63SGK30.87819117
64PRKD20.87698152
65BTK0.87554217
66SGK4940.87476086
67SGK2230.87476086
68MAP2K30.85376067
69JAK20.84777052
70RPS6KA20.84332673
71RPS6KC10.83075387
72RPS6KL10.83075387
73PTK60.82009305
74MAPK70.80949365
75ABL20.79969481
76RIPK10.79112472
77SIK10.78991098
78TTK0.78756141
79LRRK20.77191311
80PRKAA20.76165038
81MYLK0.74839777
82RPS6KA60.74657008
83HIPK20.74577332
84MAP3K80.73137508
85PRKD10.71782213
86MAPK120.70514252
87MAP2K20.70476065
88STK30.70192144
89TGFBR20.69052389
90MAP2K10.67237870
91PIK3CA0.66527198
92PRKCZ0.65928808
93SIK20.65794945
94WNK40.65683266
95STK380.64959632
96PRKD30.64410489
97MATK0.63738083
98DAPK10.63281572
99NEK20.63204787
100MAP3K110.62528889
101MAPK150.62036829
102MARK20.61847941
103ZAP700.61757124
104CAMK2G0.61525330
105PIK3CG0.61194427
106NTRK20.60431406
107EPHA20.59969579
108PLK40.59772874
109PAK30.59606101
110RIPK40.59023146
111CAMK2D0.57977889
112ARAF0.57166730
113EPHB10.56752738
114AKT30.56381211
115CDC70.55516187
116PRKCQ0.55229734
117IKBKB0.54967484
118ROCK10.54247558
119TBK10.54053693
120MAPKAPK50.53872983
121FGFR40.53795466
122MELK0.53300609
123PAK60.53037219
124MAPK40.50600885
125CAMK1D0.49913235
126PKN10.49448466
127PIM10.49252931
128PRKAA10.47942826
129JAK10.47504568
130NLK0.47475540
131GRK50.47327905
132CHUK0.47237027
133IKBKE0.46975553
134STK38L0.46459327
135PDGFRA0.46381794
136ITK0.44913263
137LCK0.43344401
138TGFBR10.43148953
139ILK0.42634156
140CSK0.40083308
141HCK0.39376549
142CDK70.38213648
143TYRO30.38077324
144STK40.37230007
145CDK40.36142606
146TEC0.35435667
147FES0.35037021
148PDK10.34706464
149BRAF0.33811144
150SCYL20.29537145
151ABL10.29397014
152OBSCN0.27533474
153SYK0.27137244
154PAK40.27070586
155RPS6KA10.26438525
156DYRK20.26393143
157MTOR0.25376948

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13369494
2Pancreatic cancer_Homo sapiens_hsa052122.10917048
3Chronic myeloid leukemia_Homo sapiens_hsa052202.10170028
4Acute myeloid leukemia_Homo sapiens_hsa052212.06757183
5Insulin secretion_Homo sapiens_hsa049112.00534152
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99306124
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.94011387
8Non-small cell lung cancer_Homo sapiens_hsa052231.84986411
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78381510
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.77230278
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.74268114
12B cell receptor signaling pathway_Homo sapiens_hsa046621.72909916
13Fatty acid degradation_Homo sapiens_hsa000711.71482006
14Other glycan degradation_Homo sapiens_hsa005111.71215690
15Arginine biosynthesis_Homo sapiens_hsa002201.69216201
16Staphylococcus aureus infection_Homo sapiens_hsa051501.62463318
17Type I diabetes mellitus_Homo sapiens_hsa049401.60604199
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50059197
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48931526
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45939127
21Prolactin signaling pathway_Homo sapiens_hsa049171.45451412
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.43849325
23mTOR signaling pathway_Homo sapiens_hsa041501.43006462
24Dorso-ventral axis formation_Homo sapiens_hsa043201.42246467
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40819052
26VEGF signaling pathway_Homo sapiens_hsa043701.38201518
27Renin secretion_Homo sapiens_hsa049241.36844898
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34025336
29Ovarian steroidogenesis_Homo sapiens_hsa049131.33182067
30Autoimmune thyroid disease_Homo sapiens_hsa053201.32419239
31Graft-versus-host disease_Homo sapiens_hsa053321.28701385
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27826594
33Vitamin B6 metabolism_Homo sapiens_hsa007501.27163326
34Allograft rejection_Homo sapiens_hsa053301.26139687
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.25301574
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25179862
37Inositol phosphate metabolism_Homo sapiens_hsa005621.24278641
38Cell cycle_Homo sapiens_hsa041101.23944130
39Histidine metabolism_Homo sapiens_hsa003401.22807545
40Endometrial cancer_Homo sapiens_hsa052131.22283385
41Insulin signaling pathway_Homo sapiens_hsa049101.21705152
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.18646209
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16915820
44Long-term potentiation_Homo sapiens_hsa047201.16657249
45Colorectal cancer_Homo sapiens_hsa052101.16610800
46Insulin resistance_Homo sapiens_hsa049311.16263239
47Complement and coagulation cascades_Homo sapiens_hsa046101.15537250
48RNA degradation_Homo sapiens_hsa030181.13946015
49Biosynthesis of amino acids_Homo sapiens_hsa012301.13437889
50Glucagon signaling pathway_Homo sapiens_hsa049221.13107110
51Circadian entrainment_Homo sapiens_hsa047131.12592025
52Lysine degradation_Homo sapiens_hsa003101.12197707
53PPAR signaling pathway_Homo sapiens_hsa033201.11272882
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10924143
55Nitrogen metabolism_Homo sapiens_hsa009101.10392760
56Renal cell carcinoma_Homo sapiens_hsa052111.09919436
57Linoleic acid metabolism_Homo sapiens_hsa005911.09727894
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09502818
59Fatty acid metabolism_Homo sapiens_hsa012121.09364355
60Thyroid cancer_Homo sapiens_hsa052161.08441823
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06479437
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05230088
63Glioma_Homo sapiens_hsa052141.05089314
64Osteoclast differentiation_Homo sapiens_hsa043801.03863204
65Central carbon metabolism in cancer_Homo sapiens_hsa052301.03203796
66Caffeine metabolism_Homo sapiens_hsa002321.03037599
67Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02695966
68Circadian rhythm_Homo sapiens_hsa047101.02408340
69Gastric acid secretion_Homo sapiens_hsa049711.02289953
70Small cell lung cancer_Homo sapiens_hsa052221.02146427
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.01876163
72Salivary secretion_Homo sapiens_hsa049701.00443958
73Toxoplasmosis_Homo sapiens_hsa051450.99603561
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99087616
75Bladder cancer_Homo sapiens_hsa052190.98709434
76Amphetamine addiction_Homo sapiens_hsa050310.98626059
77Platelet activation_Homo sapiens_hsa046110.97570409
78Oxytocin signaling pathway_Homo sapiens_hsa049210.96879614
79GnRH signaling pathway_Homo sapiens_hsa049120.95822678
80Bile secretion_Homo sapiens_hsa049760.94368326
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94168260
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92650245
83Synaptic vesicle cycle_Homo sapiens_hsa047210.92455569
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.92029048
85Calcium signaling pathway_Homo sapiens_hsa040200.91434158
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90736444
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89921700
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.89289747
89Leishmaniasis_Homo sapiens_hsa051400.88798451
90ABC transporters_Homo sapiens_hsa020100.86526579
91Propanoate metabolism_Homo sapiens_hsa006400.84555389
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84261318
93Type II diabetes mellitus_Homo sapiens_hsa049300.83640950
94Hepatitis B_Homo sapiens_hsa051610.81965468
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81539539
96Notch signaling pathway_Homo sapiens_hsa043300.81140569
97MicroRNAs in cancer_Homo sapiens_hsa052060.81077698
98cAMP signaling pathway_Homo sapiens_hsa040240.80839486
99Tryptophan metabolism_Homo sapiens_hsa003800.80159759
100beta-Alanine metabolism_Homo sapiens_hsa004100.80109241
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.79335329
102AMPK signaling pathway_Homo sapiens_hsa041520.78700642
103Choline metabolism in cancer_Homo sapiens_hsa052310.77821314
104Glycerolipid metabolism_Homo sapiens_hsa005610.77309548
105Apoptosis_Homo sapiens_hsa042100.77096536
106Fatty acid biosynthesis_Homo sapiens_hsa000610.77006892
107Dilated cardiomyopathy_Homo sapiens_hsa054140.76331364
108Glutamatergic synapse_Homo sapiens_hsa047240.76050204
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.74679075
110Long-term depression_Homo sapiens_hsa047300.74611180
111Primary immunodeficiency_Homo sapiens_hsa053400.72209052
112DNA replication_Homo sapiens_hsa030300.71328201
113Mineral absorption_Homo sapiens_hsa049780.70639861
114Carbon metabolism_Homo sapiens_hsa012000.69505440
115Shigellosis_Homo sapiens_hsa051310.68973870
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68889852
117Phenylalanine metabolism_Homo sapiens_hsa003600.68453769
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68440800
119Chemokine signaling pathway_Homo sapiens_hsa040620.68168999
120Pancreatic secretion_Homo sapiens_hsa049720.67497626
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66535104
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.65943196
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.64961814
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63652495
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63359151
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62683418
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.62246345
128Peroxisome_Homo sapiens_hsa041460.61869832
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61672353
130Fat digestion and absorption_Homo sapiens_hsa049750.60944661
131Base excision repair_Homo sapiens_hsa034100.60523442
132FoxO signaling pathway_Homo sapiens_hsa040680.60494485
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59627160
134Lysosome_Homo sapiens_hsa041420.59027431
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58913878
136Measles_Homo sapiens_hsa051620.58827566
137TGF-beta signaling pathway_Homo sapiens_hsa043500.58607164
138T cell receptor signaling pathway_Homo sapiens_hsa046600.58568528
139Arginine and proline metabolism_Homo sapiens_hsa003300.56800531
140Dopaminergic synapse_Homo sapiens_hsa047280.56481575
141Ether lipid metabolism_Homo sapiens_hsa005650.56330196
142MAPK signaling pathway_Homo sapiens_hsa040100.55733277
143Viral myocarditis_Homo sapiens_hsa054160.55621317
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54848882
145Cocaine addiction_Homo sapiens_hsa050300.54821784
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54188169
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53596331
148Cholinergic synapse_Homo sapiens_hsa047250.52141292
149Pertussis_Homo sapiens_hsa051330.52070616
150Cardiac muscle contraction_Homo sapiens_hsa042600.51680271
151HTLV-I infection_Homo sapiens_hsa051660.51105015
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50300040
153Pyruvate metabolism_Homo sapiens_hsa006200.49698124
154Asthma_Homo sapiens_hsa053100.49424356
155Galactose metabolism_Homo sapiens_hsa000520.49163747
156Estrogen signaling pathway_Homo sapiens_hsa049150.47821294
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47762426
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46946499
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.46675661
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46663958
161Focal adhesion_Homo sapiens_hsa045100.46228612
162Arachidonic acid metabolism_Homo sapiens_hsa005900.46200497
163Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46070849
164Regulation of autophagy_Homo sapiens_hsa041400.44293870

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