FBXW5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.36187814
2acrosome reaction (GO:0007340)6.10535765
3cilium or flagellum-dependent cell motility (GO:0001539)6.10444814
4fusion of sperm to egg plasma membrane (GO:0007342)5.97941930
5acrosome assembly (GO:0001675)5.21641132
6sperm-egg recognition (GO:0035036)5.21326416
7axonemal dynein complex assembly (GO:0070286)4.94702812
8plasma membrane fusion (GO:0045026)4.93153317
9cell-cell recognition (GO:0009988)4.73035299
10binding of sperm to zona pellucida (GO:0007339)4.68384291
11cell wall macromolecule catabolic process (GO:0016998)4.67024429
12cell wall macromolecule metabolic process (GO:0044036)4.67024429
13motile cilium assembly (GO:0044458)4.65946207
14tricarboxylic acid cycle (GO:0006099)4.63498932
15piRNA metabolic process (GO:0034587)4.51858454
16multicellular organism reproduction (GO:0032504)4.50257760
17regulation of cilium movement (GO:0003352)4.49179112
18spermatid development (GO:0007286)4.32165370
19carnitine transmembrane transport (GO:1902603)4.25213127
20amino-acid betaine transport (GO:0015838)4.21352862
21carnitine transport (GO:0015879)4.21352862
22calcium ion-dependent exocytosis (GO:0017156)4.14812190
23epithelial cilium movement (GO:0003351)4.07361382
24synaptonemal complex organization (GO:0070193)4.01764469
25organic cation transport (GO:0015695)4.00437263
26male meiosis (GO:0007140)3.98211824
27sperm capacitation (GO:0048240)3.93367172
28negative regulation of erythrocyte differentiation (GO:0045647)3.92785250
29negative regulation of inclusion body assembly (GO:0090084)3.85105990
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.80754518
31reproduction (GO:0000003)3.80562694
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74422078
33synaptonemal complex assembly (GO:0007130)3.64635668
34carnitine shuttle (GO:0006853)3.58478458
35mannose metabolic process (GO:0006013)3.55758140
36aspartate family amino acid catabolic process (GO:0009068)3.55719835
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53508153
38cilium movement (GO:0003341)3.51014145
39succinate metabolic process (GO:0006105)3.42655086
40barbed-end actin filament capping (GO:0051016)3.40948919
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39880169
42glycolytic process (GO:0006096)3.36116706
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34679547
44regulation of inclusion body assembly (GO:0090083)3.34653829
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.34599010
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32805421
47antigen processing and presentation of endogenous antigen (GO:0019883)3.32077044
48synaptic vesicle maturation (GO:0016188)3.30577668
49lactate metabolic process (GO:0006089)3.25743481
50quaternary ammonium group transport (GO:0015697)3.22133933
51NADH metabolic process (GO:0006734)3.19775367
52synaptic vesicle exocytosis (GO:0016079)3.17277584
53protein localization to endosome (GO:0036010)3.15660237
54cell communication by electrical coupling (GO:0010644)3.15045435
55oxaloacetate metabolic process (GO:0006107)3.14488630
56regulation of microtubule-based movement (GO:0060632)3.12647212
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12355521
58membrane depolarization during action potential (GO:0086010)3.12351228
59glutamate secretion (GO:0014047)3.11966350
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11269070
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09796572
62negative regulation of cell killing (GO:0031342)3.09796572
63negative regulation of cell size (GO:0045792)3.06322015
64fatty acid transmembrane transport (GO:1902001)3.05165698
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99877002
66single fertilization (GO:0007338)2.99739974
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98795923
68regulation of synapse structural plasticity (GO:0051823)2.97575748
69lysine metabolic process (GO:0006553)2.97324990
70lysine catabolic process (GO:0006554)2.97324990
71NIK/NF-kappaB signaling (GO:0038061)2.94637223
722-oxoglutarate metabolic process (GO:0006103)2.90817038
73regulation of fatty acid oxidation (GO:0046320)2.89849664
74gluconeogenesis (GO:0006094)2.89825776
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89775979
76positive regulation of lipoprotein lipase activity (GO:0051006)2.88383713
77positive regulation of triglyceride lipase activity (GO:0061365)2.88383713
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.88352829
79regulation of early endosome to late endosome transport (GO:2000641)2.85334840
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83806642
81sodium ion export (GO:0071436)2.83722144
82regulation of synaptic vesicle exocytosis (GO:2000300)2.81812357
83regulation of oxidative phosphorylation (GO:0002082)2.79947183
84pyruvate metabolic process (GO:0006090)2.79757787
85regulation of fatty acid beta-oxidation (GO:0031998)2.76616665
86locomotory exploration behavior (GO:0035641)2.76466619
87activation of protein kinase A activity (GO:0034199)2.75352080
88hexose biosynthetic process (GO:0019319)2.73831811
89response to peptidoglycan (GO:0032494)2.72744162
90regulation of synaptic vesicle transport (GO:1902803)2.72524534
91spermatogenesis (GO:0007283)2.71824758
92Golgi transport vesicle coating (GO:0048200)2.71362118
93COPI coating of Golgi vesicle (GO:0048205)2.71362118
94male gamete generation (GO:0048232)2.70289627
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69478265
96positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69114823
97cellular response to thyroid hormone stimulus (GO:0097067)2.68819667
98cell recognition (GO:0008037)2.67758921
99response to pheromone (GO:0019236)2.67510786
100negative regulation of potassium ion transmembrane transport (GO:1901380)2.67122074
101detection of bacterium (GO:0016045)2.66755507
102stress fiber assembly (GO:0043149)2.65400038
103modulation by symbiont of host cellular process (GO:0044068)2.64809443
104pinocytosis (GO:0006907)2.63574632
105fructose metabolic process (GO:0006000)2.62664469
106regulation of acyl-CoA biosynthetic process (GO:0050812)2.61039059
107left/right pattern formation (GO:0060972)2.60594913
108tricarboxylic acid metabolic process (GO:0072350)2.60553188
109detection of other organism (GO:0098543)2.60196959
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.59944472
111modulation by symbiont of host immune response (GO:0052553)2.59944472
112positive regulation by symbiont of host defense response (GO:0052509)2.59944472
113modulation by symbiont of host defense response (GO:0052031)2.59944472
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59944472
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59944472
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59794925
117neurotransmitter secretion (GO:0007269)2.59243455
118DNA methylation involved in gamete generation (GO:0043046)2.59197307
119urea cycle (GO:0000050)2.59183957
120sarcomere organization (GO:0045214)2.58861729
121positive regulation of receptor recycling (GO:0001921)2.58825679
122glycosphingolipid catabolic process (GO:0046479)2.57956466
123peptide catabolic process (GO:0043171)2.57573684
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57250626
125dicarboxylic acid catabolic process (GO:0043649)2.56239845
126response to thyroid hormone (GO:0097066)2.55800545
127fertilization (GO:0009566)2.55419493
128carnitine metabolic process (GO:0009437)2.55407042
129regulation of membrane repolarization (GO:0060306)2.54947530
130response to laminar fluid shear stress (GO:0034616)2.54425228
131regulation of T-helper 2 cell differentiation (GO:0045628)2.53534831
132negative regulation of organelle assembly (GO:1902116)2.51922092
133neurotransmitter-gated ion channel clustering (GO:0072578)2.51651449
134alpha-linolenic acid metabolic process (GO:0036109)2.50556966
135cellular potassium ion homeostasis (GO:0030007)2.50275999
136apoptotic process involved in morphogenesis (GO:0060561)2.49027047
137macrophage activation involved in immune response (GO:0002281)2.48901165
138cardiac muscle contraction (GO:0060048)2.48302178
139microtubule severing (GO:0051013)2.47742554
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47513171
141regulation of necrotic cell death (GO:0010939)2.46192977
142regulation of cofactor metabolic process (GO:0051193)2.46027446
143regulation of coenzyme metabolic process (GO:0051196)2.46027446
144fatty acid beta-oxidation (GO:0006635)2.45824726
145urea metabolic process (GO:0019627)2.45272938
146regulation of defense response to virus by virus (GO:0050690)2.45268215
147regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.44843415
148regulation of ARF GTPase activity (GO:0032312)2.43738899
149regulation of extracellular matrix disassembly (GO:0010715)2.43116934
150regulation of cholesterol homeostasis (GO:2000188)2.42486670
151GDP-mannose metabolic process (GO:0019673)2.42032725
152gamete generation (GO:0007276)2.40299216
153modulation by virus of host process (GO:0019054)2.40137057
154glycolipid catabolic process (GO:0019377)2.39359983
155neutrophil activation involved in immune response (GO:0002283)2.37359814
156nitrogen cycle metabolic process (GO:0071941)2.37203402
157protein retention in ER lumen (GO:0006621)2.37175149
158germinal center formation (GO:0002467)2.37030064
159positive regulation of gamma-delta T cell activation (GO:0046645)2.34950260
160regulation of cholesterol storage (GO:0010885)2.34719776
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32811912
162regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.30454881
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.30313007
164hyaluronan catabolic process (GO:0030214)2.29559146
165low-density lipoprotein particle clearance (GO:0034383)2.25800802
166positive regulation of protein dephosphorylation (GO:0035307)2.25646637
167positive thymic T cell selection (GO:0045059)2.24669992
168activation of MAPKKK activity (GO:0000185)2.24548347
169sexual reproduction (GO:0019953)2.23534263
170detection of external biotic stimulus (GO:0098581)2.23277025
171regulation of leukocyte degranulation (GO:0043300)2.22526139
172regulation of necroptotic process (GO:0060544)2.21159544
173regulation of glucose import in response to insulin stimulus (GO:2001273)2.20286302
174basement membrane organization (GO:0071711)2.19821992
175regulation of interferon-beta biosynthetic process (GO:0045357)2.18888815
176negative regulation of necroptotic process (GO:0060546)2.18272451
177positive regulation of myotube differentiation (GO:0010831)2.16105201
178angiotensin maturation (GO:0002003)2.16090856
179thymic T cell selection (GO:0045061)2.15785796
180positive regulation of fatty acid biosynthetic process (GO:0045723)2.15552542
181response to type I interferon (GO:0034340)2.15488738
182type I interferon signaling pathway (GO:0060337)2.14397523
183cellular response to type I interferon (GO:0071357)2.14397523
184adhesion of symbiont to host (GO:0044406)2.14262231
185adherens junction assembly (GO:0034333)2.13852306
186maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.12369741
187epithelial cell differentiation involved in prostate gland development (GO:0060742)2.11814496
188cell-substrate adherens junction assembly (GO:0007045)2.11589647
189focal adhesion assembly (GO:0048041)2.11589647
190regulation of fatty acid biosynthetic process (GO:0042304)2.11423750
191epithelial cell-cell adhesion (GO:0090136)2.11303131
192adenosine receptor signaling pathway (GO:0001973)2.11156631
193glucose 6-phosphate metabolic process (GO:0051156)2.10547244
194response to muramyl dipeptide (GO:0032495)2.10266318
195regulation of myeloid leukocyte mediated immunity (GO:0002886)2.10220088
196regulation of superoxide anion generation (GO:0032928)2.08825906
197negative regulation of innate immune response (GO:0045824)2.08746390
198cell-cell junction maintenance (GO:0045217)2.08689928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43970626
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.98853066
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94478795
4VDR_21846776_ChIP-Seq_THP-1_Human2.89923967
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78073593
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62144326
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.46844571
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43686870
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36200936
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.34753997
11REST_21632747_ChIP-Seq_MESCs_Mouse2.27720211
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26806763
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26570342
14RACK7_27058665_Chip-Seq_MCF-7_Human2.20919065
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17696913
16DROSHA_22980978_ChIP-Seq_HELA_Human2.16557916
17MYC_22102868_ChIP-Seq_BL_Human2.11928985
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.08367532
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03338635
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02443953
21TCF7_22412390_ChIP-Seq_EML_Mouse2.01083596
22KDM2B_26808549_Chip-Seq_DND41_Human1.96578377
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.90158319
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.89438037
25VDR_24763502_ChIP-Seq_THP-1_Human1.82131442
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78882470
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77969869
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67259746
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66027532
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65530232
31CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63596917
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63055506
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62870497
34ZNF274_21170338_ChIP-Seq_K562_Hela1.62830405
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62521345
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.60592567
37KDM2B_26808549_Chip-Seq_K562_Human1.58556981
38MAF_26560356_Chip-Seq_TH1_Human1.56126915
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55509780
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54554021
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53826905
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53123909
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.51319134
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50001076
45* LXR_22292898_ChIP-Seq_THP-1_Human1.49724994
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.47358976
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46431447
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.45936982
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.45687055
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45167870
51* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45082720
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44804084
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.44388983
54* MAF_26560356_Chip-Seq_TH2_Human1.44263008
55ZNF263_19887448_ChIP-Seq_K562_Human1.42836003
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40326761
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39476062
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.38019488
59* SMC4_20622854_ChIP-Seq_HELA_Human1.37891743
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37608573
61UTX_26944678_Chip-Seq_JUKART_Human1.37577928
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36324210
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35753533
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35271196
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34944065
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33669396
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33248130
68CTCF_27219007_Chip-Seq_Bcells_Human1.32916052
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30973016
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30958226
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.28884312
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28733688
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.28348826
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.27877901
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27865181
76P68_20966046_ChIP-Seq_HELA_Human1.26121178
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25803658
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25719597
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25625888
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25244856
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24695652
82BCL6_27268052_Chip-Seq_Bcells_Human1.23791206
83CREB1_26743006_Chip-Seq_LNCaP_Human1.23420561
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23182391
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22940430
86ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22034262
87NCOR1_26117541_ChIP-Seq_K562_Human1.21659869
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21142295
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21011903
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21001086
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.20637549
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.20637549
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20038975
94* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19581050
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17295402
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.15502891
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14951661
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14202631
99SA1_27219007_Chip-Seq_Bcells_Human1.13544911
100SPI1_23127762_ChIP-Seq_K562_Human1.13133943
101ATF3_27146783_Chip-Seq_COLON_Human1.12185559
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11860456
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11791772
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10239027
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.10151450
106* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09761935
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09745861
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09656692
109* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09519258
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09194028
111BCOR_27268052_Chip-Seq_Bcells_Human1.09052080
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.08693276
113TET1_21490601_ChIP-Seq_MESCs_Mouse1.08658484
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07724254
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07518401
116CTCF_21964334_Chip-Seq_Bcells_Human1.07470834
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07355946
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07130378
119* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07068500
120MYC_27129775_Chip-Seq_CORNEA_Mouse1.06781898
121LXR_22158963_ChIP-Seq_LIVER_Mouse1.06653469
122TP53_22127205_ChIP-Seq_IMR90_Human1.05981222
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05734046
124RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02991169
125E2F1_20622854_ChIP-Seq_HELA_Human1.02866679
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02217385
127IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02084613
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02056804
129CLOCK_20551151_ChIP-Seq_293T_Human1.01947741
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01840509
131GATA1_19941826_ChIP-Seq_K562_Human1.01834224
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01637748
133PHF8_20622854_ChIP-Seq_HELA_Human1.01141235
134* KLF4_19829295_ChIP-Seq_ESCs_Human1.00782379
135FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00628080
136OCT4_20526341_ChIP-Seq_ESCs_Human0.98773352
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97477065
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97336925
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96101227
140GBX2_23144817_ChIP-Seq_PC3_Human0.96023923
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95733380
142* SOX2_21211035_ChIP-Seq_LN229_Human0.95532109
143TP63_22573176_ChIP-Seq_HFKS_Human0.94044532
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.93349048
145* OCT4_19829295_ChIP-Seq_ESCs_Human0.92759477
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.91890316
147CTCF_20526341_ChIP-Seq_ESCs_Human0.90903209
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90521980
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88155513
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.87026177
151NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86654196
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.86317644
153P53_21459846_ChIP-Seq_SAOS-2_Human0.86316978
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86222834
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85567599
156CBP_20019798_ChIP-Seq_JUKART_Human0.85567599
157* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84711444
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84668225
159GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.84374842
160LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.84059453
161TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83896115
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82234248
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82057039
164SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82050474
165SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81984722
166RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81960109
167MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81728764
168LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81514456
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81391942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.39858975
2MP0003646_muscle_fatigue4.41971287
3MP0005451_abnormal_body_composition3.66996568
4MP0002837_dystrophic_cardiac_calcinosis3.50414630
5MP0004859_abnormal_synaptic_plasticity3.47821698
6MP0005058_abnormal_lysosome_morphology3.36077406
7MP0009840_abnormal_foam_cell3.25228569
8MP0003705_abnormal_hypodermis_morpholog3.19258271
9MP0000751_myopathy3.08486166
10MP0003191_abnormal_cellular_cholesterol2.64444136
11MP0003436_decreased_susceptibility_to2.62277890
12MP0003303_peritoneal_inflammation2.59262342
13MP0004233_abnormal_muscle_weight2.46094174
14MP0005670_abnormal_white_adipose2.43043062
15MP0004130_abnormal_muscle_cell2.38450583
16MP0004036_abnormal_muscle_relaxation2.38279621
17MP0003698_abnormal_male_reproductive2.38202707
18MP0008260_abnormal_autophagy2.36456830
19MP0004510_myositis2.19490759
20MP0002822_catalepsy2.17688483
21MP0002909_abnormal_adrenal_gland2.17524897
22MP0003635_abnormal_synaptic_transmissio2.12016081
23MP0009780_abnormal_chondrocyte_physiolo2.11458411
24MP0008877_abnormal_DNA_methylation2.04511381
25MP0003183_abnormal_peptide_metabolism2.00105730
26MP0004215_abnormal_myocardial_fiber1.99288362
27MP0000749_muscle_degeneration1.98589568
28MP0004084_abnormal_cardiac_muscle1.96122868
29MP0009046_muscle_twitch1.89378467
30MP0002653_abnormal_ependyma_morphology1.88862918
31MP0001849_ear_inflammation1.87443060
32MP0001929_abnormal_gametogenesis1.83746500
33MP0002269_muscular_atrophy1.76091979
34MP0004947_skin_inflammation1.75900579
35MP0003300_gastrointestinal_ulcer1.73322449
36MP0010234_abnormal_vibrissa_follicle1.71971449
37MP0002063_abnormal_learning/memory/cond1.69606842
38MP0005025_abnormal_response_to1.69060523
39MP0003329_amyloid_beta_deposits1.67979306
40MP0005365_abnormal_bile_salt1.67349691
41MP0006036_abnormal_mitochondrial_physio1.66539288
42MP0008569_lethality_at_weaning1.65644876
43MP0002064_seizures1.60999518
44MP0004270_analgesia1.60945098
45MP0003453_abnormal_keratinocyte_physiol1.59933184
46MP0003724_increased_susceptibility_to1.59537978
47MP0000013_abnormal_adipose_tissue1.59384409
48MP0006082_CNS_inflammation1.59113208
49MP0009278_abnormal_bone_marrow1.58044608
50MP0008961_abnormal_basal_metabolism1.57677083
51MP0002419_abnormal_innate_immunity1.56298286
52MP0009745_abnormal_behavioral_response1.54770967
53MP0004043_abnormal_pH_regulation1.54023612
54MP0009333_abnormal_splenocyte_physiolog1.52575078
55MP0004185_abnormal_adipocyte_glucose1.51529344
56MP0000858_altered_metastatic_potential1.51243226
57MP0004145_abnormal_muscle_electrophysio1.50514300
58MP0008438_abnormal_cutaneous_collagen1.50352118
59MP0004087_abnormal_muscle_fiber1.49894952
60MP0005464_abnormal_platelet_physiology1.49773116
61MP0002139_abnormal_hepatobiliary_system1.49649122
62MP0001533_abnormal_skeleton_physiology1.46813861
63MP0010155_abnormal_intestine_physiology1.44816221
64MP0000678_abnormal_parathyroid_gland1.41312758
65MP0003879_abnormal_hair_cell1.40573295
66MP0003279_aneurysm1.40091327
67MP0005000_abnormal_immune_tolerance1.39928291
68MP0001835_abnormal_antigen_presentation1.39809069
69MP0002998_abnormal_bone_remodeling1.38808769
70MP0002877_abnormal_melanocyte_morpholog1.38294829
71MP0009785_altered_susceptibility_to1.37968515
72MP0003566_abnormal_cell_adhesion1.37795396
73MP0000685_abnormal_immune_system1.37622682
74MP0001790_abnormal_immune_system1.37565294
75MP0005387_immune_system_phenotype1.37565294
76MP0003075_altered_response_to1.35954612
77MP0000747_muscle_weakness1.35339841
78MP0003763_abnormal_thymus_physiology1.34963533
79MP0002572_abnormal_emotion/affect_behav1.33475591
80MP0002272_abnormal_nervous_system1.32218982
81MP0002736_abnormal_nociception_after1.30074111
82MP0005620_abnormal_muscle_contractility1.30052174
83MP0005646_abnormal_pituitary_gland1.29760062
84MP0005409_darkened_coat_color1.29743094
85MP0004858_abnormal_nervous_system1.29190305
86MP0001968_abnormal_touch/_nociception1.29002413
87MP0005330_cardiomyopathy1.27599389
88MP0002148_abnormal_hypersensitivity_rea1.26746020
89MP0003091_abnormal_cell_migration1.26029076
90MP0001984_abnormal_olfaction1.25512457
91MP0005076_abnormal_cell_differentiation1.22677216
92MP0002161_abnormal_fertility/fecundity1.21864536
93MP0002106_abnormal_muscle_physiology1.19860473
94MP0010329_abnormal_lipoprotein_level1.19243353
95MP0001958_emphysema1.17901523
96MP0000343_altered_response_to1.17712157
97MP0004085_abnormal_heartbeat1.17561230
98MP0005166_decreased_susceptibility_to1.16880959
99MP0004811_abnormal_neuron_physiology1.16876850
100MP0003880_abnormal_central_pattern1.16559743
101MP0005671_abnormal_response_to1.16465838
102MP0001873_stomach_inflammation1.16012582
103MP0002796_impaired_skin_barrier1.13921827
104MP0002723_abnormal_immune_serum1.13908004
105MP0003137_abnormal_impulse_conducting1.13588572
106MP0005023_abnormal_wound_healing1.13089554
107MP0001765_abnormal_ion_homeostasis1.12657823
108MP0002972_abnormal_cardiac_muscle1.12201325
109MP0005535_abnormal_body_temperature1.10889209
110MP0002452_abnormal_antigen_presenting1.08367677
111MP0005584_abnormal_enzyme/coenzyme_acti1.07069842
112MP0002078_abnormal_glucose_homeostasis1.07045898
113MP0001819_abnormal_immune_cell1.06385253
114MP0002420_abnormal_adaptive_immunity1.06270876
115MP0002735_abnormal_chemical_nociception1.06119523
116MP0001800_abnormal_humoral_immune1.05798769
117MP0005360_urolithiasis1.04830987
118MP0000759_abnormal_skeletal_muscle1.04723289
119MP0008469_abnormal_protein_level1.02329318
120MP0001845_abnormal_inflammatory_respons1.02065092
121MP0003828_pulmonary_edema1.01937599
122MP0001502_abnormal_circadian_rhythm1.01901788
123MP0002067_abnormal_sensory_capabilities1.01853597
124MP0001348_abnormal_lacrimal_gland1.01224337
125MP0003633_abnormal_nervous_system1.00751035
126MP0006035_abnormal_mitochondrial_morpho1.00690531
127MP0002933_joint_inflammation1.00648247
128MP0005666_abnormal_adipose_tissue1.00521770
129MP0002734_abnormal_mechanical_nocicepti0.97741212
130MP0005332_abnormal_amino_acid0.96476791
131MP0001486_abnormal_startle_reflex0.94388236
132MP0000750_abnormal_muscle_regeneration0.94113029
133MP0002118_abnormal_lipid_homeostasis0.93871025
134MP0005369_muscle_phenotype0.93777674
135MP0001544_abnormal_cardiovascular_syste0.92111947
136MP0005385_cardiovascular_system_phenoty0.92111947
137MP0004924_abnormal_behavior0.91894601
138MP0005386_behavior/neurological_phenoty0.91894601
139MP0000733_abnormal_muscle_development0.88696033
140MP0003172_abnormal_lysosome_physiology0.88327406
141MP0002210_abnormal_sex_determination0.87697851
142MP0000003_abnormal_adipose_tissue0.86973867
143MP0002234_abnormal_pharynx_morphology0.86950179
144MP0003448_altered_tumor_morphology0.86688135
145MP0008775_abnormal_heart_ventricle0.86654278
146MP0005645_abnormal_hypothalamus_physiol0.86599642
147MP0000249_abnormal_blood_vessel0.86324583
148MP0003656_abnormal_erythrocyte_physiolo0.86149390
149MP0008874_decreased_physiological_sensi0.85454963
150MP0003806_abnormal_nucleotide_metabolis0.85257267
151MP0003866_abnormal_defecation0.84984891
152MP0008875_abnormal_xenobiotic_pharmacok0.84576474
153MP0005375_adipose_tissue_phenotype0.84248377
154MP0005257_abnormal_intraocular_pressure0.81970390
155MP0000681_abnormal_thyroid_gland0.81598244
156MP0002557_abnormal_social/conspecific_i0.81092867
157MP0000716_abnormal_immune_system0.80688334
158MP0005310_abnormal_salivary_gland0.80126548
159MP0003195_calcinosis0.80065838
160MP0004264_abnormal_extraembryonic_tissu0.78580576
161MP0002733_abnormal_thermal_nociception0.78578598
162MP0002971_abnormal_brown_adipose0.78142893
163MP0008004_abnormal_stomach_pH0.78080686
164MP0001145_abnormal_male_reproductive0.78072812
165MP0001440_abnormal_grooming_behavior0.77578974
166MP0002066_abnormal_motor_capabilities/c0.77475249
167MP0005501_abnormal_skin_physiology0.77309199
168MP0005390_skeleton_phenotype0.76889296
169MP0005165_increased_susceptibility_to0.76431345
170MP0005423_abnormal_somatic_nervous0.76157177
171MP0000604_amyloidosis0.75322993
172MP0006138_congestive_heart_failure0.73689482
173MP0003953_abnormal_hormone_level0.73565530
174MP0001501_abnormal_sleep_pattern0.73257135
175MP0005448_abnormal_energy_balance0.72196427
176MP0010630_abnormal_cardiac_muscle0.70295892

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.10622054
2Absent/shortened dynein arms (HP:0200106)5.99694507
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.99694507
4Exercise-induced myalgia (HP:0003738)4.50778904
5Abnormal respiratory motile cilium physiology (HP:0012261)4.12463378
6Myoglobinuria (HP:0002913)4.08614038
7Abnormal respiratory epithelium morphology (HP:0012253)3.98701082
8Abnormal respiratory motile cilium morphology (HP:0005938)3.98701082
9Rhinitis (HP:0012384)3.73113469
10Infertility (HP:0000789)3.71949613
11Chronic bronchitis (HP:0004469)3.70641068
12Nasal polyposis (HP:0100582)3.60233856
13Exercise-induced muscle cramps (HP:0003710)3.49206554
14Distal lower limb muscle weakness (HP:0009053)3.35488796
15Abnormality of the lower motor neuron (HP:0002366)3.33062690
16Eczematoid dermatitis (HP:0000976)3.27376095
17Bundle branch block (HP:0011710)3.16145498
18Increased connective tissue (HP:0009025)3.13989950
19Abnormality of the nasal mucosa (HP:0000433)3.12044043
20Distal lower limb amyotrophy (HP:0008944)3.07462174
21Asymmetric septal hypertrophy (HP:0001670)3.07072249
22Systemic lupus erythematosus (HP:0002725)2.96872053
23Sudden death (HP:0001699)2.93658396
24Ketoacidosis (HP:0001993)2.89330345
25Abnormal ciliary motility (HP:0012262)2.88087164
26Abnormality of macrophages (HP:0004311)2.80744215
27Ketosis (HP:0001946)2.79803050
28Calf muscle hypertrophy (HP:0008981)2.78883512
29Myokymia (HP:0002411)2.77023716
30Myopathic facies (HP:0002058)2.76825066
31Thin bony cortex (HP:0002753)2.75871723
32Vertebral compression fractures (HP:0002953)2.75610816
33Pheochromocytoma (HP:0002666)2.72586994
34Cholecystitis (HP:0001082)2.71003413
35Abnormal gallbladder physiology (HP:0012438)2.71003413
36Achilles tendon contracture (HP:0001771)2.69613534
37Dysostosis multiplex (HP:0000943)2.69138885
38Abnormality of liposaccharide metabolism (HP:0010968)2.66672388
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.66672388
40Abnormality of glycolipid metabolism (HP:0010969)2.66672388
41Malnutrition (HP:0004395)2.58379659
42Muscle hypertrophy of the lower extremities (HP:0008968)2.57612970
43Abnormality of the Achilles tendon (HP:0005109)2.57014729
44Hemorrhage of the eye (HP:0011885)2.54056621
45Rhabdomyolysis (HP:0003201)2.47892959
46Stridor (HP:0010307)2.46302571
47Neuroendocrine neoplasm (HP:0100634)2.45745707
48Bulbar palsy (HP:0001283)2.41331075
49Gout (HP:0001997)2.40735876
50Axonal loss (HP:0003447)2.40301289
51Postural instability (HP:0002172)2.40099813
52Protrusio acetabuli (HP:0003179)2.39612962
53Type 1 muscle fiber predominance (HP:0003803)2.37477259
54Abnormality of skeletal muscle fiber size (HP:0012084)2.36942957
55Epileptic encephalopathy (HP:0200134)2.35920290
56Increased variability in muscle fiber diameter (HP:0003557)2.35313089
57Recurrent abscess formation (HP:0002722)2.34307052
58Cellulitis (HP:0100658)2.33783125
59Bronchitis (HP:0012387)2.32795430
60Cerebral aneurysm (HP:0004944)2.32174378
61Gingivitis (HP:0000230)2.31413940
62Premature rupture of membranes (HP:0001788)2.31173537
63Visual hallucinations (HP:0002367)2.30424970
64Recurrent gram-negative bacterial infections (HP:0005420)2.29128808
65Ventricular fibrillation (HP:0001663)2.28649901
66Broad face (HP:0000283)2.28480690
67Upper limb amyotrophy (HP:0009129)2.27931894
68Distal upper limb amyotrophy (HP:0007149)2.27931894
69Abnormality of complement system (HP:0005339)2.27814364
70Cervical subluxation (HP:0003308)2.27729873
71Urinary glycosaminoglycan excretion (HP:0003541)2.25924575
72Mucopolysacchariduria (HP:0008155)2.25924575
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25288287
74Abnormality of polysaccharide metabolism (HP:0011012)2.25288287
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25288287
76Hypertriglyceridemia (HP:0002155)2.25253189
77Hyporeflexia of lower limbs (HP:0002600)2.24324968
78Mildly elevated creatine phosphokinase (HP:0008180)2.23440683
79Dysmetric saccades (HP:0000641)2.22690466
80Purpura (HP:0000979)2.21375423
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.19217670
82Focal motor seizures (HP:0011153)2.16008072
83Colitis (HP:0002583)2.15515277
84Palpitations (HP:0001962)2.13952260
85Impaired vibration sensation in the lower limbs (HP:0002166)2.13730669
86Abnormality of the calf musculature (HP:0001430)2.11245004
87Increased cerebral lipofuscin (HP:0011813)2.11127012
88Central scotoma (HP:0000603)2.11067453
89Late onset (HP:0003584)2.10523670
90J-shaped sella turcica (HP:0002680)2.09591678
91Polydipsia (HP:0001959)2.08548566
92Abnormal drinking behavior (HP:0030082)2.08548566
93Heart block (HP:0012722)2.08109865
94Difficulty climbing stairs (HP:0003551)2.08025933
95Hyperventilation (HP:0002883)2.07734743
96Hyperinsulinemic hypoglycemia (HP:0000825)2.07177117
97Increased serum ferritin (HP:0003281)2.07172575
98Prolonged QT interval (HP:0001657)2.06557243
99Atrial fibrillation (HP:0005110)2.06076715
100Difficulty running (HP:0009046)2.04873622
101Deep venous thrombosis (HP:0002625)2.04329585
102Amyloidosis (HP:0011034)2.03232429
103Nephronophthisis (HP:0000090)2.02278210
104Supranuclear gaze palsy (HP:0000605)2.01466440
105Depression (HP:0000716)2.01313238
106Large for gestational age (HP:0001520)2.00629362
107Recurrent bacterial skin infections (HP:0005406)2.00291502
108Loss of speech (HP:0002371)1.99297462
109Ulnar bowing (HP:0003031)1.98645132
110Joint stiffness (HP:0001387)1.98362293
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98044248
112Myocardial infarction (HP:0001658)1.97035650
113Ankle clonus (HP:0011448)1.96892205
114Male infertility (HP:0003251)1.96349525
115Lower limb amyotrophy (HP:0007210)1.95550204
116Bronchiectasis (HP:0002110)1.95292414
117Gastrointestinal infarctions (HP:0005244)1.94709288
118Increased IgE level (HP:0003212)1.94608486
119Ragged-red muscle fibers (HP:0003200)1.94304111
120Obstructive sleep apnea (HP:0002870)1.94018292
121Left ventricular hypertrophy (HP:0001712)1.93953051
122Petechiae (HP:0000967)1.92854680
123Easy fatigability (HP:0003388)1.92337441
124Ventricular tachycardia (HP:0004756)1.91765064
125Muscle fiber splitting (HP:0003555)1.91005538
126Hyperacusis (HP:0010780)1.90808708
127Interstitial pulmonary disease (HP:0006530)1.90626985
128Emphysema (HP:0002097)1.88264869
129Impaired social interactions (HP:0000735)1.88210707
130Abnormal social behavior (HP:0012433)1.88210707
131Primary atrial arrhythmia (HP:0001692)1.88153500
132Hypoglycemic coma (HP:0001325)1.87084961
133Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86826221
134Muscle fiber inclusion bodies (HP:0100299)1.86818663
135Xanthomatosis (HP:0000991)1.86587450
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86412066
137Myotonia (HP:0002486)1.85786654
138Abnormal EKG (HP:0003115)1.85554745
139Complement deficiency (HP:0004431)1.83879621
140Syncope (HP:0001279)1.83721897
141EMG: myopathic abnormalities (HP:0003458)1.83711174
142Poor eye contact (HP:0000817)1.83614125
143Abnormality of fatty-acid metabolism (HP:0004359)1.83378368
144Recurrent otitis media (HP:0000403)1.83291744
145Neoplasm of the heart (HP:0100544)1.82675677
146Cholelithiasis (HP:0001081)1.82090688
147Obstructive lung disease (HP:0006536)1.81344296
148Chronic obstructive pulmonary disease (HP:0006510)1.81344296
149Spinal rigidity (HP:0003306)1.79807860
150Gastrointestinal inflammation (HP:0004386)1.79725672
151Abnormal atrioventricular conduction (HP:0005150)1.79718873
152Supraventricular tachycardia (HP:0004755)1.79439709
153Resting tremor (HP:0002322)1.78324970
154Impaired vibratory sensation (HP:0002495)1.77847020
155Nemaline bodies (HP:0003798)1.77490496
156Polycythemia (HP:0001901)1.77238240
157Oligomenorrhea (HP:0000876)1.76519630
158Status epilepticus (HP:0002133)1.76189155
159Increased neuronal autofluorescent lipopigment (HP:0002074)1.75039607
160Flat acetabular roof (HP:0003180)1.74797944
161EMG: neuropathic changes (HP:0003445)1.74090081
162Impaired proprioception (HP:0010831)1.74060454
163Supraventricular arrhythmia (HP:0005115)1.73808268
164Thoracic kyphosis (HP:0002942)1.72554796
165Medial flaring of the eyebrow (HP:0010747)1.72204415
166Bone pain (HP:0002653)1.71824545
167Ventricular arrhythmia (HP:0004308)1.70872075
168Abnormal gallbladder morphology (HP:0012437)1.70662774
169Hyperammonemia (HP:0001987)1.70614216
170Abnormality of saccadic eye movements (HP:0000570)1.70549278
171Nuclear cataract (HP:0100018)1.69695886
172Focal seizures (HP:0007359)1.69581757
173Myositis (HP:0100614)1.69427123
174Progressive neurologic deterioration (HP:0002344)1.69328737
175Polygenic inheritance (HP:0010982)1.69269374
176Abnormality of the thoracic spine (HP:0100711)1.68769753
177Hyperparathyroidism (HP:0000843)1.68489551
178Aneurysm (HP:0002617)1.68418845
179Glomerulonephritis (HP:0000099)1.68041664
180Gastrointestinal dysmotility (HP:0002579)1.67819357
181Death in childhood (HP:0003819)1.67762725
182Fragile skin (HP:0001030)1.67417974
183Neoplasm of the peripheral nervous system (HP:0100007)1.66612825
184Flattened epiphyses (HP:0003071)1.66307024
185Muscle stiffness (HP:0003552)1.66143772
186Anosmia (HP:0000458)1.65707290
187Inflammation of the large intestine (HP:0002037)1.65351164
188Abnormal urine output (HP:0012590)1.64871637
189Cerebral inclusion bodies (HP:0100314)1.63954483
190Dysdiadochokinesis (HP:0002075)1.63142304
191Gonadotropin excess (HP:0000837)1.62984471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.73659251
2PDK35.73659251
3PRKD34.84414000
4TESK13.38066403
5TRIB33.35429443
6PDK23.16916624
7ICK2.54894170
8IRAK32.54350691
9SMG12.25055687
10MAP2K32.08551684
11TESK22.02340570
12LMTK22.01571600
13PHKG22.00107470
14PHKG12.00107470
15MAP3K111.99324904
16PTK2B1.78270491
17NME21.77352389
18DAPK21.75895806
19WNK41.66493892
20STK381.59275159
21TBK11.58540574
22BCKDK1.56998343
23MAP3K41.49625673
24MST1R1.49245103
25EPHA21.48846512
26PKN21.47746787
27TAOK21.47376490
28PINK11.47226661
29MAP3K31.44896685
30NEK11.44511925
31CAMKK11.43277480
32TYK21.39292238
33TTN1.36568652
34EPHA41.29419819
35NTRK21.26650643
36EPHB11.26041029
37DAPK11.25377639
38BLK1.22180058
39SIK31.18540665
40DDR21.15975559
41MAP3K131.14855490
42ERN11.14414136
43MAP2K71.14265452
44NTRK31.10643469
45MINK11.10536367
46MYLK1.10298523
47PRKD21.09970837
48CCNB11.06893841
49PAK61.03557100
50CSK1.02606397
51IRAK41.02511558
52GRK61.02068168
53PDK11.00483995
54MARK10.96810779
55MAP3K90.96566535
56PAK40.95953573
57RIPK10.95181541
58MAP2K40.94103346
59SIK10.93234880
60TAOK10.90826658
61TNK20.89436374
62JAK30.87339715
63TYRO30.84983239
64PIM20.83275537
65SGK30.83247590
66PRKG20.82298075
67RPS6KC10.81618756
68RPS6KL10.81618756
69PDGFRA0.81146179
70CAMK1G0.80552633
71INSRR0.78427588
72KDR0.78094005
73SGK4940.76980123
74SGK2230.76980123
75SGK20.76856980
76RPS6KA20.76772991
77MAP3K60.76489029
78CAMKK20.76203305
79PDPK10.75809246
80IRAK20.73928382
81OBSCN0.73832421
82MAPK110.72680746
83PRKAA10.72657160
84MAP2K60.70621899
85BMX0.67560389
86MAP2K20.67484468
87FES0.66838569
88PRKCH0.66501660
89MAP3K140.66089782
90BRAF0.66084206
91MTOR0.65679812
92MUSK0.65214101
93CDK50.64848219
94SIK20.63228425
95NTRK10.63082130
96ABL20.62421226
97TGFBR20.62407470
98IKBKE0.61030025
99DYRK1B0.60596253
100CDK190.59952594
101RPS6KA60.59707797
102JAK10.59646256
103MOS0.59160426
104HCK0.58968935
105BTK0.58197680
106MAPKAPK30.57703950
107CAMK10.57660041
108PTK20.57148332
109MAP3K70.56051627
110PRKCG0.54776559
111KSR20.54774122
112EEF2K0.54153271
113MAP3K80.49710458
114CAMK40.49131570
115LRRK20.48409557
116MARK20.47464083
117TXK0.46980759
118HIPK20.46738206
119DMPK0.45711950
120RET0.43971545
121MAPK120.42422952
122DAPK30.42086880
123IKBKB0.41842469
124PAK30.41325783
125TAOK30.41086936
126MAP3K100.40393735
127MAPK40.39477122
128WNK10.39462949
129PRKD10.39203784
130MAPK70.38494501
131SYK0.38190337
132CDK120.37902193
133UHMK10.36831265
134CAMK2A0.36529097
135ILK0.36312348
136MAP4K10.35803016
137MAP3K10.35670762
138FGR0.35327134
139PRPF4B0.34204337
140PRKACG0.33414894
141MAP3K120.32995038
142PTK60.31711189
143PRKCZ0.31557857
144CDK180.31529413
145CDC42BPA0.30916902
146RIPK40.30702213
147MAPK150.30349121
148CDK150.29015866
149RPS6KB10.28568583
150STK110.28304456
151WNK30.27759524
152CAMK2G0.27706840
153STK390.27305204
154FGFR40.26382763
155ZAP700.26162613
156RPS6KA30.25779311
157FLT30.25045716
158ARAF0.24819705
159CAMK2D0.24632317
160MAPK130.24227553

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.94488034
2Other glycan degradation_Homo sapiens_hsa005113.27669638
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95731809
4Propanoate metabolism_Homo sapiens_hsa006402.86130279
5Pyruvate metabolism_Homo sapiens_hsa006202.84307837
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.57636395
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.27949541
8Fatty acid degradation_Homo sapiens_hsa000712.25913070
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21875179
10Nitrogen metabolism_Homo sapiens_hsa009102.17369424
11Synaptic vesicle cycle_Homo sapiens_hsa047212.13844303
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08406025
13Carbon metabolism_Homo sapiens_hsa012002.01444705
14Glucagon signaling pathway_Homo sapiens_hsa049221.94127189
15Fatty acid metabolism_Homo sapiens_hsa012121.93288239
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84611140
17Osteoclast differentiation_Homo sapiens_hsa043801.76413779
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.69182588
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68552202
20Acute myeloid leukemia_Homo sapiens_hsa052211.66052098
21Insulin secretion_Homo sapiens_hsa049111.64159639
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59749684
23Lysosome_Homo sapiens_hsa041421.55211061
24Staphylococcus aureus infection_Homo sapiens_hsa051501.53074342
25Leishmaniasis_Homo sapiens_hsa051401.51989565
26Fatty acid biosynthesis_Homo sapiens_hsa000611.50540757
27Sulfur relay system_Homo sapiens_hsa041221.50124883
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49715304
29Amphetamine addiction_Homo sapiens_hsa050311.47464242
30VEGF signaling pathway_Homo sapiens_hsa043701.46382505
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44893773
32Butanoate metabolism_Homo sapiens_hsa006501.44701834
33Cardiac muscle contraction_Homo sapiens_hsa042601.44366499
34Biosynthesis of amino acids_Homo sapiens_hsa012301.44017685
35Olfactory transduction_Homo sapiens_hsa047401.43741367
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42430714
37B cell receptor signaling pathway_Homo sapiens_hsa046621.42258491
38Circadian entrainment_Homo sapiens_hsa047131.40587287
39PPAR signaling pathway_Homo sapiens_hsa033201.40266155
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39528118
41Prion diseases_Homo sapiens_hsa050201.39445333
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37152665
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30053005
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26747862
45Long-term potentiation_Homo sapiens_hsa047201.25331013
46Fructose and mannose metabolism_Homo sapiens_hsa000511.24125044
47Arginine biosynthesis_Homo sapiens_hsa002201.21145136
48Pertussis_Homo sapiens_hsa051331.16555881
49Viral myocarditis_Homo sapiens_hsa054161.16392481
50Bladder cancer_Homo sapiens_hsa052191.12650420
51Tuberculosis_Homo sapiens_hsa051521.11301917
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10685650
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10322549
54GABAergic synapse_Homo sapiens_hsa047271.10063726
55Toxoplasmosis_Homo sapiens_hsa051451.10052988
56Chronic myeloid leukemia_Homo sapiens_hsa052201.09589329
57TNF signaling pathway_Homo sapiens_hsa046681.08964005
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.08599666
59Morphine addiction_Homo sapiens_hsa050321.08277003
60Non-small cell lung cancer_Homo sapiens_hsa052231.06547773
61Notch signaling pathway_Homo sapiens_hsa043301.06513480
62Renin secretion_Homo sapiens_hsa049241.05957350
63Nicotine addiction_Homo sapiens_hsa050331.04720711
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02749728
65Malaria_Homo sapiens_hsa051441.01376291
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00075098
67Hepatitis C_Homo sapiens_hsa051600.99702950
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.99662058
69Pentose phosphate pathway_Homo sapiens_hsa000300.99465586
70Gastric acid secretion_Homo sapiens_hsa049710.98564005
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98043306
72Dopaminergic synapse_Homo sapiens_hsa047280.97500628
73Type II diabetes mellitus_Homo sapiens_hsa049300.96237030
74Glycerolipid metabolism_Homo sapiens_hsa005610.94781886
75Insulin resistance_Homo sapiens_hsa049310.94661761
76Endocytosis_Homo sapiens_hsa041440.93787363
77Amoebiasis_Homo sapiens_hsa051460.93753210
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92997836
79Influenza A_Homo sapiens_hsa051640.92073021
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91720312
81Allograft rejection_Homo sapiens_hsa053300.91357812
82Insulin signaling pathway_Homo sapiens_hsa049100.90890070
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88492626
84Pancreatic cancer_Homo sapiens_hsa052120.88333386
85Salmonella infection_Homo sapiens_hsa051320.87811659
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.86511086
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.86222658
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86220947
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85731238
90Glutamatergic synapse_Homo sapiens_hsa047240.85726617
91Vitamin B6 metabolism_Homo sapiens_hsa007500.85476710
92Collecting duct acid secretion_Homo sapiens_hsa049660.85468298
93Calcium signaling pathway_Homo sapiens_hsa040200.85451091
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85396421
95Peroxisome_Homo sapiens_hsa041460.84369693
96Autoimmune thyroid disease_Homo sapiens_hsa053200.84106289
97AMPK signaling pathway_Homo sapiens_hsa041520.82995605
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.82943191
99Cocaine addiction_Homo sapiens_hsa050300.82335163
100Bile secretion_Homo sapiens_hsa049760.82092841
101Complement and coagulation cascades_Homo sapiens_hsa046100.81221278
102Salivary secretion_Homo sapiens_hsa049700.81142856
103Graft-versus-host disease_Homo sapiens_hsa053320.80857033
104Dilated cardiomyopathy_Homo sapiens_hsa054140.80801469
105GnRH signaling pathway_Homo sapiens_hsa049120.80540713
106Apoptosis_Homo sapiens_hsa042100.79597637
107Selenocompound metabolism_Homo sapiens_hsa004500.78734856
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.77943904
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76878276
110Renin-angiotensin system_Homo sapiens_hsa046140.74964562
111Tryptophan metabolism_Homo sapiens_hsa003800.74529989
112Oxytocin signaling pathway_Homo sapiens_hsa049210.74237384
113Chemokine signaling pathway_Homo sapiens_hsa040620.73902842
114T cell receptor signaling pathway_Homo sapiens_hsa046600.73863954
115Cholinergic synapse_Homo sapiens_hsa047250.73056580
116Platelet activation_Homo sapiens_hsa046110.72007074
117Shigellosis_Homo sapiens_hsa051310.71710682
118Circadian rhythm_Homo sapiens_hsa047100.71298760
119Focal adhesion_Homo sapiens_hsa045100.70761448
120cAMP signaling pathway_Homo sapiens_hsa040240.68337493
121Phagosome_Homo sapiens_hsa041450.67319779
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.66815143
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65464822
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65381247
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63747857
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63179906
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.60961290
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60576729
129Estrogen signaling pathway_Homo sapiens_hsa049150.60562483
130Hepatitis B_Homo sapiens_hsa051610.59295132
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.58607755
132Endometrial cancer_Homo sapiens_hsa052130.57064707
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55890963
134Antigen processing and presentation_Homo sapiens_hsa046120.54998563
135Prolactin signaling pathway_Homo sapiens_hsa049170.54633271
136Herpes simplex infection_Homo sapiens_hsa051680.53494367
137Dorso-ventral axis formation_Homo sapiens_hsa043200.53371500
138Renal cell carcinoma_Homo sapiens_hsa052110.52992006
139Pancreatic secretion_Homo sapiens_hsa049720.52936045
140Fat digestion and absorption_Homo sapiens_hsa049750.52842255
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52507589
142Choline metabolism in cancer_Homo sapiens_hsa052310.52413840
143Thyroid hormone synthesis_Homo sapiens_hsa049180.52212794
144Vibrio cholerae infection_Homo sapiens_hsa051100.51757638
145ABC transporters_Homo sapiens_hsa020100.50633991
146Glioma_Homo sapiens_hsa052140.50551424
147beta-Alanine metabolism_Homo sapiens_hsa004100.50272280
148Starch and sucrose metabolism_Homo sapiens_hsa005000.50051316
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.49793855
150Taste transduction_Homo sapiens_hsa047420.49611998
151Measles_Homo sapiens_hsa051620.48790604
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48237125
153Galactose metabolism_Homo sapiens_hsa000520.46810945
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.46463983
155Sulfur metabolism_Homo sapiens_hsa009200.46176887
156Legionellosis_Homo sapiens_hsa051340.44970160
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44616704
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.44498669
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44462821
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44394151
161Proteoglycans in cancer_Homo sapiens_hsa052050.43940478
162HIF-1 signaling pathway_Homo sapiens_hsa040660.43860358
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39101852
164Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38738389
165Phenylalanine metabolism_Homo sapiens_hsa003600.37671742
166alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37198226
167Lysine degradation_Homo sapiens_hsa003100.34744633
168mTOR signaling pathway_Homo sapiens_hsa041500.32760901

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