FBXW7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.58419115
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.57051841
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52649845
4synaptic vesicle exocytosis (GO:0016079)5.50422547
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.32768636
6protein localization to synapse (GO:0035418)5.31575399
7glutamate secretion (GO:0014047)5.26841106
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24569095
9neuronal action potential propagation (GO:0019227)5.14501092
10neuron cell-cell adhesion (GO:0007158)5.10893987
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.04030156
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.02165453
13regulation of glutamate receptor signaling pathway (GO:1900449)4.94936370
14glutamate receptor signaling pathway (GO:0007215)4.92135682
15presynaptic membrane assembly (GO:0097105)4.86896149
16regulation of synaptic vesicle exocytosis (GO:2000300)4.85406751
17gamma-aminobutyric acid signaling pathway (GO:0007214)4.68153730
18neuron-neuron synaptic transmission (GO:0007270)4.57048681
19synaptic transmission, glutamatergic (GO:0035249)4.55323641
20neurotransmitter-gated ion channel clustering (GO:0072578)4.48471827
21presynaptic membrane organization (GO:0097090)4.46088926
22piRNA metabolic process (GO:0034587)4.42853434
23regulation of synaptic vesicle transport (GO:1902803)4.37075444
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35847290
25locomotory exploration behavior (GO:0035641)4.33378898
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22566765
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.22286301
28postsynaptic membrane organization (GO:0001941)4.17901696
29synaptic vesicle maturation (GO:0016188)4.15453827
30positive regulation of synapse maturation (GO:0090129)4.11206024
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.11168272
32long-term synaptic potentiation (GO:0060291)4.10486864
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09898327
34synapsis (GO:0007129)4.09510572
35response to histamine (GO:0034776)4.09331848
36regulation of postsynaptic membrane potential (GO:0060078)4.06222629
37negative regulation of cytosolic calcium ion concentration (GO:0051481)4.04874875
38neuron recognition (GO:0008038)4.00121524
39regulation of neuronal synaptic plasticity (GO:0048168)3.87958725
40neurotransmitter secretion (GO:0007269)3.86896879
41male meiosis I (GO:0007141)3.81535708
42positive regulation of neurotransmitter secretion (GO:0001956)3.80093346
43regulation of synaptic plasticity (GO:0048167)3.77668409
44exploration behavior (GO:0035640)3.74238816
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67248688
46synaptic vesicle endocytosis (GO:0048488)3.64600233
47cerebellar granule cell differentiation (GO:0021707)3.59967305
48long-term memory (GO:0007616)3.59508679
49behavioral fear response (GO:0001662)3.58471358
50behavioral defense response (GO:0002209)3.58471358
51axonal fasciculation (GO:0007413)3.56581612
52regulation of glutamate secretion (GO:0014048)3.54551406
53startle response (GO:0001964)3.53725820
54positive regulation of membrane potential (GO:0045838)3.53679156
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.53063802
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52841439
57regulation of dendritic spine morphogenesis (GO:0061001)3.50555677
58fear response (GO:0042596)3.49382025
59regulation of neurotransmitter secretion (GO:0046928)3.47409074
60retinal cone cell development (GO:0046549)3.44502885
61positive regulation of meiosis (GO:0045836)3.43052219
62behavioral response to cocaine (GO:0048148)3.38511916
63cerebellar Purkinje cell differentiation (GO:0021702)3.37771929
64DNA methylation involved in gamete generation (GO:0043046)3.37067585
65regulation of synapse maturation (GO:0090128)3.36636964
66regulation of vesicle fusion (GO:0031338)3.36234203
67membrane depolarization (GO:0051899)3.34813672
68positive regulation of neurotransmitter transport (GO:0051590)3.31540698
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29692072
70male meiosis (GO:0007140)3.28667421
71transmission of nerve impulse (GO:0019226)3.27909903
72negative regulation of dendrite morphogenesis (GO:0050774)3.27766637
73auditory behavior (GO:0031223)3.27064466
74detection of calcium ion (GO:0005513)3.26303605
75regulation of dendritic spine development (GO:0060998)3.26034359
76protein K11-linked deubiquitination (GO:0035871)3.24166685
77dendritic spine morphogenesis (GO:0060997)3.23439568
78cochlea development (GO:0090102)3.21379543
79neurotransmitter transport (GO:0006836)3.21059476
80regulation of meiosis I (GO:0060631)3.21006243
81long term synaptic depression (GO:0060292)3.20926272
82positive regulation of synapse assembly (GO:0051965)3.18180309
83positive regulation of meiotic cell cycle (GO:0051446)3.18012235
84learning (GO:0007612)3.16524623
85cellular potassium ion homeostasis (GO:0030007)3.14448669
86innervation (GO:0060384)3.12739558
87membrane depolarization during action potential (GO:0086010)3.12498027
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12479571
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10799542
90regulation of neurotransmitter transport (GO:0051588)3.10271728
91synaptic transmission (GO:0007268)3.09654908
92negative regulation of amino acid transport (GO:0051956)3.09255261
93regulation of voltage-gated calcium channel activity (GO:1901385)3.06557201
94serotonin metabolic process (GO:0042428)3.04900431
95regulation of synaptic transmission (GO:0050804)3.04210846
96proline transport (GO:0015824)3.04153886
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02637349
98positive regulation of synaptic transmission (GO:0050806)3.02145100
99ATP hydrolysis coupled proton transport (GO:0015991)3.00535808
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00535808
101negative regulation of neurotransmitter transport (GO:0051589)3.00363091
102chromosome organization involved in meiosis (GO:0070192)3.00346935
103gamma-aminobutyric acid transport (GO:0015812)3.00231051
104activation of protein kinase A activity (GO:0034199)3.00039332
105regulation of synapse structural plasticity (GO:0051823)2.99431004
106dendritic spine organization (GO:0097061)2.99308567
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98556217
108potassium ion import (GO:0010107)2.98065793
109synapse assembly (GO:0007416)2.97488373
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97241261
111mechanosensory behavior (GO:0007638)2.94962477
112negative regulation of dendrite development (GO:2000171)2.94903252
113transferrin transport (GO:0033572)2.94636217
114regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.93447785
115meiosis I (GO:0007127)2.91473037
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.91086329
117L-amino acid import (GO:0043092)2.90513727
118regulation of neurotransmitter levels (GO:0001505)2.90019397
119primary amino compound metabolic process (GO:1901160)2.83645732
120growth hormone receptor signaling pathway (GO:0060396)2.81580730
121brain morphogenesis (GO:0048854)2.76481293
122C4-dicarboxylate transport (GO:0015740)2.76378353
123synaptonemal complex organization (GO:0070193)2.74003131
124chemosensory behavior (GO:0007635)2.73872628
125glycerophospholipid catabolic process (GO:0046475)2.72294219
126central nervous system myelination (GO:0022010)2.65367888
127axon ensheathment in central nervous system (GO:0032291)2.65367888
128neuronal action potential (GO:0019228)2.64007422
129regulation of protein glycosylation (GO:0060049)2.63957664
130establishment of protein localization to Golgi (GO:0072600)2.62978943
131potassium ion transmembrane transport (GO:0071805)2.60818566
132cellular potassium ion transport (GO:0071804)2.60818566
133neurotransmitter uptake (GO:0001504)2.58982021
134glycosphingolipid biosynthetic process (GO:0006688)2.53438512
135potassium ion transport (GO:0006813)2.52564067
136regulation of neurotransmitter uptake (GO:0051580)2.49670655
137cellular response to ethanol (GO:0071361)2.48966817
138protein targeting to Golgi (GO:0000042)2.48676510
139* positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.47956501
140response to pheromone (GO:0019236)2.47912443
141cellular response to growth hormone stimulus (GO:0071378)2.44188075
142nerve growth factor signaling pathway (GO:0038180)2.43652635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23429967
2GBX2_23144817_ChIP-Seq_PC3_Human4.57282407
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12140465
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02892140
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98472500
6TAF15_26573619_Chip-Seq_HEK293_Human2.66819659
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63007996
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57549575
9REST_21632747_ChIP-Seq_MESCs_Mouse2.57258756
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52460354
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52460354
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44681048
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44585148
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38640823
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36594554
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.33955481
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30963005
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.30810290
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27638596
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27336381
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23134726
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16467813
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02203264
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99820540
25SMAD4_21799915_ChIP-Seq_A2780_Human1.99649679
26* REST_18959480_ChIP-ChIP_MESCs_Mouse1.98335742
27DROSHA_22980978_ChIP-Seq_HELA_Human1.96824414
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94723313
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94542121
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92221539
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.91841458
32* P300_19829295_ChIP-Seq_ESCs_Human1.89645283
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89334126
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.81681525
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80796250
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77359043
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76164964
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75031576
39* FUS_26573619_Chip-Seq_HEK293_Human1.70441924
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67661043
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67525028
42AR_21572438_ChIP-Seq_LNCaP_Human1.67339972
43VDR_22108803_ChIP-Seq_LS180_Human1.66903742
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65601167
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.64347216
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.63714766
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62834039
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60348308
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.50854514
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48708051
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47950585
52AR_25329375_ChIP-Seq_VCAP_Human1.46819976
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43413082
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.43233090
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37650854
56* STAT3_23295773_ChIP-Seq_U87_Human1.37183284
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37027051
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36997261
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36757862
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35942988
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35933068
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35632743
63* CBP_20019798_ChIP-Seq_JUKART_Human1.35569360
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35569360
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35356651
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35203248
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34036375
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.30780836
69RNF2_27304074_Chip-Seq_NSC_Mouse1.29308869
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29252517
71* TCF4_23295773_ChIP-Seq_U87_Human1.29172478
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28239152
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26568589
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.26075254
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.25489491
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23610025
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.23523381
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22871738
79TP53_16413492_ChIP-PET_HCT116_Human1.21283359
80* PRDM14_20953172_ChIP-Seq_ESCs_Human1.21136553
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19961444
82TCF4_22108803_ChIP-Seq_LS180_Human1.19812831
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.19097285
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18053755
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.17603303
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17209485
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15729867
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14777853
89AR_19668381_ChIP-Seq_PC3_Human1.13854822
90ER_23166858_ChIP-Seq_MCF-7_Human1.13479089
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.13424128
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13178565
93TP53_18474530_ChIP-ChIP_U2OS_Human1.12851129
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12002009
95* JUN_21703547_ChIP-Seq_K562_Human1.11248005
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.11017277
97* AHR_22903824_ChIP-Seq_MCF-7_Human1.10031582
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09627274
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09098308
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09098308
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09080032
102* NANOG_19829295_ChIP-Seq_ESCs_Human1.08303636
103* SOX2_19829295_ChIP-Seq_ESCs_Human1.08303636
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07669879
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07616810
106* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07437742
107CDX2_22108803_ChIP-Seq_LS180_Human1.07222087
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.06885425
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06876101
110IGF1R_20145208_ChIP-Seq_DFB_Human1.06627310
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.06382734
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05983055
113* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05972966
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05735718
115P300_18555785_Chip-Seq_ESCs_Mouse1.05017382
116* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04995934
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.04848738
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04190167
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.03388001
120SOX9_26525672_Chip-Seq_HEART_Mouse1.03260067
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.03215340
122BCAT_22108803_ChIP-Seq_LS180_Human1.02677093
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01852900
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01763629
125* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01683982
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01361368
127KDM2B_26808549_Chip-Seq_REH_Human1.00057407
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99847315
129EWS_26573619_Chip-Seq_HEK293_Human0.99036529
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98984643
131P53_22387025_ChIP-Seq_ESCs_Mouse0.98727798
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97613345
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96562187
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96322059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.08730061
2MP0004859_abnormal_synaptic_plasticity6.00274456
3MP0003635_abnormal_synaptic_transmissio4.10600711
4MP0009745_abnormal_behavioral_response3.58486187
5MP0004270_analgesia3.54655481
6MP0001968_abnormal_touch/_nociception3.50240275
7MP0002063_abnormal_learning/memory/cond3.41999851
8MP0002064_seizures3.20214287
9MP0009046_muscle_twitch3.06247074
10MP0002736_abnormal_nociception_after3.04149180
11MP0000569_abnormal_digit_pigmentation2.99070793
12MP0002572_abnormal_emotion/affect_behav2.92797265
13MP0002272_abnormal_nervous_system2.64307473
14MP0002735_abnormal_chemical_nociception2.60929916
15MP0001501_abnormal_sleep_pattern2.48073644
16MP0001440_abnormal_grooming_behavior2.45545318
17MP0002734_abnormal_mechanical_nocicepti2.45326279
18MP0001486_abnormal_startle_reflex2.32817875
19MP0002067_abnormal_sensory_capabilities2.20237515
20MP0005423_abnormal_somatic_nervous2.07425970
21MP0008057_abnormal_DNA_replication1.98011687
22MP0002138_abnormal_hepatobiliary_system1.94597887
23MP0009780_abnormal_chondrocyte_physiolo1.92724824
24MP0002837_dystrophic_cardiac_calcinosis1.90793476
25MP0003879_abnormal_hair_cell1.88619583
26MP0002733_abnormal_thermal_nociception1.86683770
27MP0001970_abnormal_pain_threshold1.86682488
28MP0001188_hyperpigmentation1.84769171
29MP0000778_abnormal_nervous_system1.84046612
30MP0003787_abnormal_imprinting1.82806854
31MP0001986_abnormal_taste_sensitivity1.81354728
32MP0002184_abnormal_innervation1.80998506
33MP0002822_catalepsy1.77288848
34MP0006276_abnormal_autonomic_nervous1.69545954
35MP0004924_abnormal_behavior1.69208286
36MP0005386_behavior/neurological_phenoty1.69208286
37MP0001984_abnormal_olfaction1.67307952
38MP0002557_abnormal_social/conspecific_i1.65038893
39MP0003329_amyloid_beta_deposits1.58730644
40MP0008569_lethality_at_weaning1.55992989
41MP0005646_abnormal_pituitary_gland1.55697385
42MP0002638_abnormal_pupillary_reflex1.50404675
43MP0001529_abnormal_vocalization1.44642215
44* MP0004811_abnormal_neuron_physiology1.44595267
45MP0004145_abnormal_muscle_electrophysio1.40026164
46MP0000955_abnormal_spinal_cord1.35292898
47MP0002066_abnormal_motor_capabilities/c1.32517016
48MP0010234_abnormal_vibrissa_follicle1.31421891
49MP0006072_abnormal_retinal_apoptosis1.30585794
50MP0005174_abnormal_tail_pigmentation1.30310537
51* MP0002882_abnormal_neuron_morphology1.29229109
52MP0000427_abnormal_hair_cycle1.27221357
53MP0002909_abnormal_adrenal_gland1.25561854
54MP0001905_abnormal_dopamine_level1.23720735
55MP0004142_abnormal_muscle_tone1.23338997
56MP0001502_abnormal_circadian_rhythm1.22737496
57MP0000751_myopathy1.21958374
58MP0004858_abnormal_nervous_system1.21855676
59MP0002876_abnormal_thyroid_physiology1.21387651
60MP0003633_abnormal_nervous_system1.19661877
61MP0005253_abnormal_eye_physiology1.16924385
62MP0004484_altered_response_of1.16773805
63MP0003045_fibrosis1.15919749
64MP0003122_maternal_imprinting1.12015610
65MP0004043_abnormal_pH_regulation1.08289836
66MP0004215_abnormal_myocardial_fiber1.04008949
67MP0003631_nervous_system_phenotype1.02959711
68* MP0002152_abnormal_brain_morphology1.00005993
69MP0002928_abnormal_bile_duct0.96903232
70MP0005171_absent_coat_pigmentation0.96534978
71MP0005645_abnormal_hypothalamus_physiol0.95930023
72MP0001963_abnormal_hearing_physiology0.95349718
73MP0010386_abnormal_urinary_bladder0.95328063
74MP0008872_abnormal_physiological_respon0.94584689
75MP0005551_abnormal_eye_electrophysiolog0.94317817
76MP0004085_abnormal_heartbeat0.92965609
77MP0005409_darkened_coat_color0.90981464
78MP0003698_abnormal_male_reproductive0.90540923
79MP0004742_abnormal_vestibular_system0.90101317
80MP0008877_abnormal_DNA_methylation0.89940770
81MP0004885_abnormal_endolymph0.89579696
82MP0008874_decreased_physiological_sensi0.89199373
83MP0003690_abnormal_glial_cell0.87645977
84MP0001929_abnormal_gametogenesis0.86361854
85MP0005389_reproductive_system_phenotype0.85730640
86MP0002229_neurodegeneration0.85436006
87MP0010678_abnormal_skin_adnexa0.84507452
88MP0002166_altered_tumor_susceptibility0.84185840
89MP0002095_abnormal_skin_pigmentation0.83854987
90MP0003195_calcinosis0.83498506
91MP0004510_myositis0.82946333
92MP0005167_abnormal_blood-brain_barrier0.82867821
93MP0002160_abnormal_reproductive_system0.82351637
94MP0002069_abnormal_eating/drinking_beha0.82350090
95MP0002210_abnormal_sex_determination0.81337089
96MP0002693_abnormal_pancreas_physiology0.78032403
97MP0001485_abnormal_pinna_reflex0.77845552
98MP0005394_taste/olfaction_phenotype0.75847935
99MP0005499_abnormal_olfactory_system0.75847935
100MP0002752_abnormal_somatic_nervous0.74664529
101MP0000631_abnormal_neuroendocrine_gland0.74116407
102MP0000013_abnormal_adipose_tissue0.73784553
103MP0005535_abnormal_body_temperature0.73432413
104MP0005220_abnormal_exocrine_pancreas0.70905549
105MP0002102_abnormal_ear_morphology0.69627421
106MP0000920_abnormal_myelination0.68645649
107MP0004233_abnormal_muscle_weight0.67645250
108MP0008058_abnormal_DNA_repair0.67313125
109MP0001664_abnormal_digestion0.67279342
110MP0003632_abnormal_nervous_system0.65073470
111MP0000026_abnormal_inner_ear0.64706539
112MP0000653_abnormal_sex_gland0.64673262
113MP0006292_abnormal_olfactory_placode0.64303040
114MP0000604_amyloidosis0.62974082
115MP0001177_atelectasis0.58333751
116MP0003183_abnormal_peptide_metabolism0.58017094
117MP0003646_muscle_fatigue0.56815515
118MP0001943_abnormal_respiration0.56580164
119MP0005620_abnormal_muscle_contractility0.55195780
120MP0004036_abnormal_muscle_relaxation0.53388742
121MP0003121_genomic_imprinting0.52437549
122MP0002751_abnormal_autonomic_nervous0.51936838
123MP0000015_abnormal_ear_pigmentation0.51738817
124MP0005623_abnormal_meninges_morphology0.51504568
125MP0010770_preweaning_lethality0.50807337
126MP0002082_postnatal_lethality0.50807337
127MP0010769_abnormal_survival0.49916414
128MP0003137_abnormal_impulse_conducting0.49754222
129MP0005187_abnormal_penis_morphology0.48629259
130* MP0003861_abnormal_nervous_system0.48323605

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.26435666
2Epileptic encephalopathy (HP:0200134)6.38847963
3Atonic seizures (HP:0010819)6.37032153
4Focal seizures (HP:0007359)6.00115694
5Febrile seizures (HP:0002373)5.67755711
6Hyperventilation (HP:0002883)5.50892784
7Absence seizures (HP:0002121)5.05080258
8Myokymia (HP:0002411)4.97764343
9Visual hallucinations (HP:0002367)4.75101601
10Dialeptic seizures (HP:0011146)4.68465432
11Broad-based gait (HP:0002136)4.25130126
12Progressive cerebellar ataxia (HP:0002073)4.20874801
13Generalized tonic-clonic seizures (HP:0002069)3.98244693
14Amblyopia (HP:0000646)3.77455649
15Gaze-evoked nystagmus (HP:0000640)3.67636922
16Volvulus (HP:0002580)3.44572423
17Poor eye contact (HP:0000817)3.44472290
18Drooling (HP:0002307)3.22302191
19Excessive salivation (HP:0003781)3.22302191
20Truncal ataxia (HP:0002078)3.06258499
21Protruding tongue (HP:0010808)3.04110718
22Epileptiform EEG discharges (HP:0011182)2.98135246
23Dysdiadochokinesis (HP:0002075)2.96774129
24Abnormal social behavior (HP:0012433)2.93758421
25Impaired social interactions (HP:0000735)2.93758421
26Impaired vibration sensation in the lower limbs (HP:0002166)2.93185859
27Thyroiditis (HP:0100646)2.91274802
28Absent speech (HP:0001344)2.91031525
29Impaired smooth pursuit (HP:0007772)2.87036422
30Dysmetria (HP:0001310)2.81610432
31Scanning speech (HP:0002168)2.80303053
32Inability to walk (HP:0002540)2.77604054
33Dysmetric saccades (HP:0000641)2.67056341
34Papilledema (HP:0001085)2.64194004
35Oligodactyly (hands) (HP:0001180)2.61967761
36Abnormality of the axillary hair (HP:0100134)2.51952844
37Abnormality of secondary sexual hair (HP:0009888)2.51952844
38EEG with generalized epileptiform discharges (HP:0011198)2.51762235
39Action tremor (HP:0002345)2.50518790
40Urinary bladder sphincter dysfunction (HP:0002839)2.49442952
41Hemiparesis (HP:0001269)2.48722931
42Genetic anticipation (HP:0003743)2.45798393
43Amyotrophic lateral sclerosis (HP:0007354)2.44634158
44Hemiplegia (HP:0002301)2.44272719
45Abnormal eating behavior (HP:0100738)2.42772525
46Depression (HP:0000716)2.42008752
47Anxiety (HP:0000739)2.40097861
48Gait imbalance (HP:0002141)2.39940337
49Termporal pattern (HP:0011008)2.39289090
50Insidious onset (HP:0003587)2.39289090
51Neoplasm of the adrenal cortex (HP:0100641)2.36134822
52Abnormality of binocular vision (HP:0011514)2.34930656
53Diplopia (HP:0000651)2.34930656
54Stereotypic behavior (HP:0000733)2.34803861
55Stomach cancer (HP:0012126)2.34631549
56Supranuclear gaze palsy (HP:0000605)2.34559164
57Abnormality of ocular smooth pursuit (HP:0000617)2.32657992
58Status epilepticus (HP:0002133)2.32621568
59Blue irides (HP:0000635)2.30627811
60Abnormal hair whorl (HP:0010721)2.30493978
61Increased circulating renin level (HP:0000848)2.27633753
62Bundle branch block (HP:0011710)2.26201880
63Abnormality of the lower motor neuron (HP:0002366)2.25569388
64Hyperkalemia (HP:0002153)2.23790214
65Cerebral inclusion bodies (HP:0100314)2.23502239
66Hypsarrhythmia (HP:0002521)2.21392376
67Abnormality of the renal cortex (HP:0011035)2.21000337
68Fair hair (HP:0002286)2.20436211
69Fetal akinesia sequence (HP:0001989)2.19505509
70Abnormality of salivation (HP:0100755)2.18036327
71Short chin (HP:0000331)2.16728088
72Progressive inability to walk (HP:0002505)2.15763292
73Congenital primary aphakia (HP:0007707)2.15537751
74Medial flaring of the eyebrow (HP:0010747)2.15239122
75Impaired vibratory sensation (HP:0002495)2.14917677
76Generalized hypopigmentation of hair (HP:0011358)2.14377298
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14136968
78Pancreatic cysts (HP:0001737)2.13422291
79Intention tremor (HP:0002080)2.09920578
80Syncope (HP:0001279)2.08823162
81Generalized myoclonic seizures (HP:0002123)2.08502996
82Dry hair (HP:0011359)2.07883119
83Horizontal nystagmus (HP:0000666)2.04742503
84Hyperthyroidism (HP:0000836)2.04595421
85Urinary urgency (HP:0000012)2.04077714
86Thickened helices (HP:0000391)2.01587951
87Abnormality of the corticospinal tract (HP:0002492)1.99819190
88Bradykinesia (HP:0002067)1.99365776
89Postural instability (HP:0002172)1.98997586
90Nephrogenic diabetes insipidus (HP:0009806)1.98468340
91Polydipsia (HP:0001959)1.97321009
92Abnormal drinking behavior (HP:0030082)1.97321009
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.96290411
94Absent/shortened dynein arms (HP:0200106)1.96290411
95Delusions (HP:0000746)1.95322872
96Acute necrotizing encephalopathy (HP:0006965)1.94703895
97Congenital, generalized hypertrichosis (HP:0004540)1.93778425
98Incomplete penetrance (HP:0003829)1.93452225
99Intestinal atresia (HP:0011100)1.92396342
100Widely spaced teeth (HP:0000687)1.91670194
101Abnormality of the renal medulla (HP:0100957)1.90370743
102Progressive macrocephaly (HP:0004481)1.89601625
103Polyphagia (HP:0002591)1.88636291
104Lower limb amyotrophy (HP:0007210)1.87673924
105Gait ataxia (HP:0002066)1.87671425
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.87592520
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87592520
108Papillary thyroid carcinoma (HP:0002895)1.87517315
109Pancreatic fibrosis (HP:0100732)1.87512430
110Congenital stationary night blindness (HP:0007642)1.86858011
111Specific learning disability (HP:0001328)1.85186936
112True hermaphroditism (HP:0010459)1.83054655
113Decreased circulating renin level (HP:0003351)1.82922847
114Gastroesophageal reflux (HP:0002020)1.81825095
115Pheochromocytoma (HP:0002666)1.81643618
116Ventricular fibrillation (HP:0001663)1.80867617
117Sensory axonal neuropathy (HP:0003390)1.80800229
118Abnormal mitochondria in muscle tissue (HP:0008316)1.79984056
119Agammaglobulinemia (HP:0004432)1.79279140
120Chronic sinusitis (HP:0011109)1.79106534
121Exotropia (HP:0000577)1.78884616
122Hypothermia (HP:0002045)1.77145757
123Lower limb muscle weakness (HP:0007340)1.76853823
124Hypoventilation (HP:0002791)1.76336243
125Nephronophthisis (HP:0000090)1.76202954
126Tubulointerstitial nephritis (HP:0001970)1.75231757
127Spastic gait (HP:0002064)1.73615479
128Abnormality of the labia minora (HP:0012880)1.72441066
129Thyroid-stimulating hormone excess (HP:0002925)1.71402683
130Abnormal EKG (HP:0003115)1.70586343
131Abnormality of B cell number (HP:0010975)1.68805946
132Ankle clonus (HP:0011448)1.68434406
133Limb dystonia (HP:0002451)1.67405319
134Muscle hypertrophy of the lower extremities (HP:0008968)1.66854274
135Hydroureter (HP:0000072)1.66313947
136Deeply set eye (HP:0000490)1.65774762
137Autism (HP:0000717)1.65753378
138Psychosis (HP:0000709)1.64148735
139Supernumerary spleens (HP:0009799)1.64049858
140Heart block (HP:0012722)1.63833196
141Retinal dysplasia (HP:0007973)1.63276742
142Poor coordination (HP:0002370)1.63248790
143Shoulder girdle muscle weakness (HP:0003547)1.62980403
144Hematochezia (HP:0002573)1.61119749
145Prolonged QT interval (HP:0001657)1.60977507
146Optic nerve hypoplasia (HP:0000609)1.60784186
147Central scotoma (HP:0000603)1.58946605
148Slow-growing hair (HP:0002217)1.57520701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.41683201
2EPHA45.19882483
3CASK4.89897644
4NTRK34.50198144
5MAP3K43.18634456
6RIPK43.14456769
7MAP2K73.00063989
8DAPK22.86862783
9MAP3K92.71376589
10MAP3K122.69270670
11BMPR1B2.46872311
12DAPK12.35637445
13MINK12.12456111
14PNCK2.00141892
15CDK191.98876891
16CCNB11.96833928
17MAP2K41.88478043
18AKT31.72177335
19BMPR21.70168233
20KSR11.68284082
21MARK11.67316776
22STK38L1.66357935
23FGFR21.63123609
24EIF2AK31.56012677
25GRK51.55004494
26PINK11.51808946
27* PLK21.43581490
28PRPF4B1.43570259
29PAK61.40915102
30ACVR1B1.37225866
31NTRK21.35789236
32ARAF1.32766543
33KSR21.32273893
34ADRBK21.27916476
35CDK51.26149163
36PTK2B1.25716832
37FGFR31.24450095
38SIK21.23410242
39TNIK1.22319131
40CAMK2A1.21370263
41PRKCG1.20309792
42CAMKK21.19184547
43SIK31.15973351
44MAPK131.15818451
45STK241.15713042
46NME11.12449460
47NTRK11.11160522
48CAMK2B1.10214024
49MKNK21.07942525
50STK391.07653322
51OXSR11.07035356
52FES1.06872495
53CAMKK11.06330902
54TAOK30.98360786
55MAP3K130.96886791
56GRK10.94472308
57SGK20.93094580
58FGR0.88898984
59RAF10.87211307
60CAMK1G0.86819848
61WNK10.86485236
62ZAK0.86180694
63SGK2230.83063656
64SGK4940.83063656
65KIT0.83048220
66SYK0.82396374
67MAP4K20.81122518
68MAP3K20.77888489
69BRAF0.77244443
70CAMK10.73531455
71MET0.73445969
72NLK0.71199019
73CDK180.70417416
74WNK40.68718947
75GRK70.68200734
76NUAK10.67707446
77STK380.67407704
78ERBB30.66867385
79MAP2K60.65351668
80DYRK1A0.64156136
81CDK140.63408015
82CDK150.62876378
83* SGK10.62357596
84UHMK10.61537570
85CAMK2D0.61481275
86STK110.61429782
87BRD40.61087259
88OBSCN0.59726871
89DAPK30.59491955
90PDK40.56987613
91PDK30.56987613
92TGFBR10.56958110
93CSF1R0.56315824
94MARK20.55519166
95FER0.54243826
96CDK11A0.52332798
97GRK60.51875469
98PRKD30.51865568
99PDK10.51664526
100SGK30.51186360
101* PRKCE0.51115777
102TEC0.50600765
103BCR0.48742450
104MAPK120.48383783
105CSNK1G20.48087354
106PDPK10.47220982
107PRKG10.45431400
108STK30.45087789
109TNK20.44379878
110RET0.44175630
111MAPK70.43371863
112CDK30.43064944
113ADRBK10.42927981
114CSNK1G10.42912444
115ROCK20.42794552
116PKN10.42319563
117RPS6KB10.42296356
118CAMK2G0.42109597
119YES10.41316683
120WNK30.41298269
121MAP3K60.41202032
122MAPKAPK50.40834913
123PRKCQ0.40541268
124TRPM70.40290688
125CSNK1D0.40093413
126TAF10.39771412
127TSSK60.39664011
128PAK30.38173688
129CSNK1A1L0.37547664
130MAP2K10.37282325
131JAK10.36977696
132TYRO30.36509811
133RPS6KA30.36348354
134CAMK40.36034703
135MUSK0.35467656
136PHKG20.35356008
137PHKG10.35356008
138PRKACA0.34538708
139MAP3K10.34260676
140PRKCH0.33491580
141DMPK0.33174521
142LATS20.30833426
143NEK60.30728054
144PRKCZ0.29775611
145PRKCB0.28663239

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.40340608
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36989987
3Long-term potentiation_Homo sapiens_hsa047203.09298039
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98720612
5Circadian entrainment_Homo sapiens_hsa047132.77871229
6Amphetamine addiction_Homo sapiens_hsa050312.70392819
7Glutamatergic synapse_Homo sapiens_hsa047242.63272315
8Morphine addiction_Homo sapiens_hsa050322.57937433
9GABAergic synapse_Homo sapiens_hsa047272.50110635
10Olfactory transduction_Homo sapiens_hsa047402.49211062
11Collecting duct acid secretion_Homo sapiens_hsa049662.44996056
12Salivary secretion_Homo sapiens_hsa049702.28024843
13Dopaminergic synapse_Homo sapiens_hsa047282.16531597
14Taste transduction_Homo sapiens_hsa047422.13652975
15Renin secretion_Homo sapiens_hsa049241.96405148
16Insulin secretion_Homo sapiens_hsa049111.91675723
17Long-term depression_Homo sapiens_hsa047301.88855946
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88341942
19Serotonergic synapse_Homo sapiens_hsa047261.83304808
20Calcium signaling pathway_Homo sapiens_hsa040201.80033828
21Oxytocin signaling pathway_Homo sapiens_hsa049211.76299095
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.75245560
23Gastric acid secretion_Homo sapiens_hsa049711.73882481
24Cholinergic synapse_Homo sapiens_hsa047251.67826682
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67387437
26Asthma_Homo sapiens_hsa053101.61298924
27Vibrio cholerae infection_Homo sapiens_hsa051101.52042444
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51120755
29Cocaine addiction_Homo sapiens_hsa050301.38668012
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34449272
31GnRH signaling pathway_Homo sapiens_hsa049121.32764706
32cAMP signaling pathway_Homo sapiens_hsa040241.28566494
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27733126
34Oxidative phosphorylation_Homo sapiens_hsa001901.27216142
35Allograft rejection_Homo sapiens_hsa053301.26345627
36Cardiac muscle contraction_Homo sapiens_hsa042601.23135500
37Gap junction_Homo sapiens_hsa045401.21956467
38Autoimmune thyroid disease_Homo sapiens_hsa053201.21427480
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19617223
40Regulation of autophagy_Homo sapiens_hsa041401.17860076
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.17548911
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15024375
43Graft-versus-host disease_Homo sapiens_hsa053321.13536058
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13533988
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13220620
46Phototransduction_Homo sapiens_hsa047441.12782594
47Alzheimers disease_Homo sapiens_hsa050101.12177870
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12072223
49Vitamin B6 metabolism_Homo sapiens_hsa007501.10659412
50Axon guidance_Homo sapiens_hsa043601.08995356
51Estrogen signaling pathway_Homo sapiens_hsa049151.03536177
52Melanogenesis_Homo sapiens_hsa049161.03208778
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03157079
54Ether lipid metabolism_Homo sapiens_hsa005651.00417967
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99914585
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.97971126
57Glioma_Homo sapiens_hsa052140.95028609
58Type II diabetes mellitus_Homo sapiens_hsa049300.90804045
59ErbB signaling pathway_Homo sapiens_hsa040120.90047906
60Primary immunodeficiency_Homo sapiens_hsa053400.88644966
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88338013
62Pancreatic secretion_Homo sapiens_hsa049720.85622212
63Oocyte meiosis_Homo sapiens_hsa041140.85179094
64Non-homologous end-joining_Homo sapiens_hsa034500.81330134
65Nitrogen metabolism_Homo sapiens_hsa009100.80274285
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77657847
67Dilated cardiomyopathy_Homo sapiens_hsa054140.77564316
68Parkinsons disease_Homo sapiens_hsa050120.73902143
69MAPK signaling pathway_Homo sapiens_hsa040100.72083508
70B cell receptor signaling pathway_Homo sapiens_hsa046620.71115289
71Dorso-ventral axis formation_Homo sapiens_hsa043200.70848186
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68144288
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67947245
74Linoleic acid metabolism_Homo sapiens_hsa005910.67112208
75ABC transporters_Homo sapiens_hsa020100.65558527
76African trypanosomiasis_Homo sapiens_hsa051430.64806223
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64485449
78Glucagon signaling pathway_Homo sapiens_hsa049220.62720370
79Huntingtons disease_Homo sapiens_hsa050160.62605358
80Rheumatoid arthritis_Homo sapiens_hsa053230.62461528
81Thyroid hormone synthesis_Homo sapiens_hsa049180.62037948
82Circadian rhythm_Homo sapiens_hsa047100.61483491
83RNA degradation_Homo sapiens_hsa030180.61090820
84Choline metabolism in cancer_Homo sapiens_hsa052310.59830081
85Protein export_Homo sapiens_hsa030600.58779913
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58301358
87Butanoate metabolism_Homo sapiens_hsa006500.56587660
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.56370179
89Ras signaling pathway_Homo sapiens_hsa040140.55906410
90VEGF signaling pathway_Homo sapiens_hsa043700.54422909
91Inositol phosphate metabolism_Homo sapiens_hsa005620.54039991
92Basal transcription factors_Homo sapiens_hsa030220.52093519
93Systemic lupus erythematosus_Homo sapiens_hsa053220.48558149
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.47870169
95Rap1 signaling pathway_Homo sapiens_hsa040150.46900900
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46803263
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46200469
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45255643
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.45009683
100T cell receptor signaling pathway_Homo sapiens_hsa046600.44681019
101Wnt signaling pathway_Homo sapiens_hsa043100.43798644
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41179027
103Tuberculosis_Homo sapiens_hsa051520.41043517
104Alcoholism_Homo sapiens_hsa050340.40699262
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40516601
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37627313
107Type I diabetes mellitus_Homo sapiens_hsa049400.37330390
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35916129
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35565264
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34451150
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.34093403
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33924739
113* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33265438
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32720798
115Phagosome_Homo sapiens_hsa041450.32686121
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31422610
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31130712
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29512969
119Mineral absorption_Homo sapiens_hsa049780.28540146
120mTOR signaling pathway_Homo sapiens_hsa041500.28105336
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26042074
122Renal cell carcinoma_Homo sapiens_hsa052110.25486024
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23427440
124Melanoma_Homo sapiens_hsa052180.23301627
125Ovarian steroidogenesis_Homo sapiens_hsa049130.23035126
126Non-small cell lung cancer_Homo sapiens_hsa052230.22520419
127Insulin signaling pathway_Homo sapiens_hsa049100.22304172
128Prion diseases_Homo sapiens_hsa050200.21654864

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