FBXW8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.24193022
2regulation of fatty acid beta-oxidation (GO:0031998)3.76454393
3basement membrane organization (GO:0071711)3.71113230
4bone trabecula formation (GO:0060346)3.65545252
5maternal placenta development (GO:0001893)3.65146928
6positive regulation of fatty acid beta-oxidation (GO:0032000)3.64908788
7regulation of hippo signaling (GO:0035330)3.63864218
8apoptotic cell clearance (GO:0043277)3.54548874
9polarized epithelial cell differentiation (GO:0030859)3.53565005
10protein heterotrimerization (GO:0070208)3.47259557
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.45752348
12negative regulation of cell size (GO:0045792)3.43248233
134-hydroxyproline metabolic process (GO:0019471)3.40243947
14COPII vesicle coating (GO:0048208)3.40097587
15hippo signaling (GO:0035329)3.38509259
16alpha-linolenic acid metabolic process (GO:0036109)3.30815428
17regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25429416
18nuclear pore complex assembly (GO:0051292)3.24796457
19paraxial mesoderm development (GO:0048339)3.24162006
20adherens junction assembly (GO:0034333)3.22842203
21chondrocyte development (GO:0002063)3.19795564
22negative regulation of fatty acid transport (GO:2000192)3.18575067
23establishment of apical/basal cell polarity (GO:0035089)3.18480197
24negative regulation of DNA repair (GO:0045738)3.09873933
25biotin metabolic process (GO:0006768)3.09725330
26plasma membrane repair (GO:0001778)3.08288629
27epithelial cell-cell adhesion (GO:0090136)3.07969415
28lysine catabolic process (GO:0006554)3.06579365
29lysine metabolic process (GO:0006553)3.06579365
30positive regulation of fatty acid oxidation (GO:0046321)3.04587565
31regulation of cholesterol homeostasis (GO:2000188)3.04444754
32negative regulation of fibrinolysis (GO:0051918)3.01620644
33regulation of translational fidelity (GO:0006450)3.01009347
34endocardial cushion development (GO:0003197)2.95932524
35positive regulation of glycogen biosynthetic process (GO:0045725)2.93561954
36heterochromatin organization (GO:0070828)2.91918619
37activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90906922
38Golgi transport vesicle coating (GO:0048200)2.90670854
39COPI coating of Golgi vesicle (GO:0048205)2.90670854
40cell-substrate junction assembly (GO:0007044)2.89883290
41pentose-phosphate shunt (GO:0006098)2.89702975
42regulation of SMAD protein import into nucleus (GO:0060390)2.87132025
43cytoskeletal anchoring at plasma membrane (GO:0007016)2.86845732
44regulation of cholesterol storage (GO:0010885)2.86695343
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85700727
46positive regulation of SMAD protein import into nucleus (GO:0060391)2.83904553
47mesenchymal-epithelial cell signaling (GO:0060638)2.83719545
48skin morphogenesis (GO:0043589)2.83277992
49type B pancreatic cell proliferation (GO:0044342)2.81741758
50positive regulation of nuclease activity (GO:0032075)2.80580402
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79505595
52regulation of establishment of planar polarity (GO:0090175)2.79468708
53nucleosome disassembly (GO:0006337)2.78765650
54protein-DNA complex disassembly (GO:0032986)2.78765650
55cell adhesion mediated by integrin (GO:0033627)2.78126432
56nuclear pore organization (GO:0006999)2.78124011
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.78012607
58protein localization to endosome (GO:0036010)2.77708260
59regulation of fatty acid oxidation (GO:0046320)2.77538146
60NADPH regeneration (GO:0006740)2.74353108
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74172647
62focal adhesion assembly (GO:0048041)2.73258228
63cell-substrate adherens junction assembly (GO:0007045)2.73258228
64endodermal cell differentiation (GO:0035987)2.72574975
65morphogenesis of an epithelial sheet (GO:0002011)2.72412433
66convergent extension (GO:0060026)2.69902676
67collagen fibril organization (GO:0030199)2.69307356
68sulfur amino acid catabolic process (GO:0000098)2.66990453
69negative regulation of fibroblast apoptotic process (GO:2000270)2.66095778
70positive regulation of histone deacetylation (GO:0031065)2.65192894
71plasma lipoprotein particle clearance (GO:0034381)2.64458566
72regulation of gene silencing by RNA (GO:0060966)2.63779869
73regulation of posttranscriptional gene silencing (GO:0060147)2.63779869
74regulation of gene silencing by miRNA (GO:0060964)2.63779869
75negative regulation of chondrocyte differentiation (GO:0032331)2.62079866
76notochord development (GO:0030903)2.61972346
77protein hydroxylation (GO:0018126)2.59161346
78cell migration involved in sprouting angiogenesis (GO:0002042)2.56709554
79folic acid-containing compound biosynthetic process (GO:0009396)2.56346588
80positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56045253
81regulation of RNA export from nucleus (GO:0046831)2.55832861
82blood vessel endothelial cell migration (GO:0043534)2.55601503
83stress fiber assembly (GO:0043149)2.55158565
84establishment of monopolar cell polarity (GO:0061162)2.54907658
85establishment or maintenance of monopolar cell polarity (GO:0061339)2.54907658
86positive regulation of triglyceride biosynthetic process (GO:0010867)2.54763690
87glyoxylate metabolic process (GO:0046487)2.54672323
88regulation of histone H3-K27 methylation (GO:0061085)2.54532209
89establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.54406991
90negative regulation of axon extension involved in axon guidance (GO:0048843)2.53577982
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.53576400
92endoplasmic reticulum unfolded protein response (GO:0030968)2.53169039
93peptidyl-lysine dimethylation (GO:0018027)2.52926101
94peptidyl-proline hydroxylation (GO:0019511)2.52074708
95regulation of tight junction assembly (GO:2000810)2.51686034
96chondrocyte proliferation (GO:0035988)2.51176266
97midgut development (GO:0007494)2.50743085
98regulation of nuclease activity (GO:0032069)2.48982206
99vascular endothelial growth factor signaling pathway (GO:0038084)2.48813996
100endothelial cell morphogenesis (GO:0001886)2.48199922
101epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47083336
102pore complex assembly (GO:0046931)2.46877010
103apoptotic process involved in morphogenesis (GO:0060561)2.45988348
104positive regulation of glycogen metabolic process (GO:0070875)2.45953565
105positive regulation of cellular response to insulin stimulus (GO:1900078)2.44953946
106pericardium development (GO:0060039)2.44263764
107tricarboxylic acid metabolic process (GO:0072350)2.44147546
108acetyl-CoA metabolic process (GO:0006084)2.42537000
109white fat cell differentiation (GO:0050872)2.42129304
110positive regulation of p38MAPK cascade (GO:1900745)2.41785677
111anterior/posterior axis specification, embryo (GO:0008595)2.39973835
1122-oxoglutarate metabolic process (GO:0006103)2.39799893
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39633944
114L-phenylalanine metabolic process (GO:0006558)2.39633944
115regulation of p38MAPK cascade (GO:1900744)2.39343245
116embryonic camera-type eye morphogenesis (GO:0048596)2.38304743
117negative regulation of lipid transport (GO:0032369)2.38139210
118cellular response to unfolded protein (GO:0034620)2.38126950
119protein localization to cell surface (GO:0034394)2.38098583
120renal filtration (GO:0097205)2.38068751
121positive regulation of triglyceride metabolic process (GO:0090208)2.36798754
122cortical actin cytoskeleton organization (GO:0030866)2.36188001
123embryonic digit morphogenesis (GO:0042733)2.35780680
124embryonic foregut morphogenesis (GO:0048617)2.35531741
125valine metabolic process (GO:0006573)2.34832306
126glomerular basement membrane development (GO:0032836)2.33648873
127glycine metabolic process (GO:0006544)2.33634595
128axon extension involved in axon guidance (GO:0048846)2.33513392
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.33513392
130ER-nucleus signaling pathway (GO:0006984)2.33385379
131glutamine metabolic process (GO:0006541)2.33328151
132branching involved in salivary gland morphogenesis (GO:0060445)2.32862836
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.32703591
134nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.31178070
135regulation of axon extension involved in axon guidance (GO:0048841)2.30173784
136fibroblast migration (GO:0010761)2.29945923
137sequestering of extracellular ligand from receptor (GO:0035581)2.27849795
138regulation of centriole replication (GO:0046599)2.27837547
139dosage compensation (GO:0007549)2.27131520
140regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.26767381
141retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25531832
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25413708
143non-canonical Wnt signaling pathway (GO:0035567)2.25339463
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24678597
145pyrimidine dimer repair (GO:0006290)2.24425524
146G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24215128
147protein retention in ER lumen (GO:0006621)2.23447825
148ectodermal placode formation (GO:0060788)2.23065545
149establishment of planar polarity (GO:0001736)2.22544886
150establishment of tissue polarity (GO:0007164)2.22544886
151positive regulation of smoothened signaling pathway (GO:0045880)2.22315332
152mitochondrial DNA metabolic process (GO:0032042)2.21793880
153dorsal/ventral axis specification (GO:0009950)2.20879933
154ganglion development (GO:0061548)2.20141803
155mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.19663778
156membrane protein ectodomain proteolysis (GO:0006509)2.17871508
157eye morphogenesis (GO:0048592)2.17035392
158establishment or maintenance of bipolar cell polarity (GO:0061245)2.16756073
159establishment or maintenance of apical/basal cell polarity (GO:0035088)2.16756073
160regulation of transforming growth factor beta2 production (GO:0032909)2.15718169
161negative regulation of embryonic development (GO:0045992)2.14755850
162embryonic eye morphogenesis (GO:0048048)2.13881053
163cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.13871330
164muscle cell migration (GO:0014812)2.13818143
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13614780
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.13318450
167negative chemotaxis (GO:0050919)2.12862463
168atrial septum morphogenesis (GO:0060413)2.11293592
169glucocorticoid receptor signaling pathway (GO:0042921)2.10629374
170DNA duplex unwinding (GO:0032508)2.10338647
171lymphangiogenesis (GO:0001946)2.10047077
172negative regulation of osteoblast proliferation (GO:0033689)2.09385293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51002714
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69713631
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.57255497
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.24554540
5CLOCK_20551151_ChIP-Seq_293T_Human3.17225482
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15686991
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05957588
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.96142305
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.94994240
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.89750030
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.77214422
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68594466
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66402834
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.60988008
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58957394
16BRD4_25478319_ChIP-Seq_HGPS_Human2.57115564
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.55786744
18ZNF263_19887448_ChIP-Seq_K562_Human2.49382758
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.38063010
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27530784
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.16366661
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14788147
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.14523332
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13720416
25ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08046870
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.01593917
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97698735
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.96995915
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95925955
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93077479
31* AHR_22903824_ChIP-Seq_MCF-7_Human1.92088474
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.90851546
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90694088
34LXR_22292898_ChIP-Seq_THP-1_Human1.89992328
35RACK7_27058665_Chip-Seq_MCF-7_Human1.89511463
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88431954
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83522877
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80483375
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.80166324
40MYC_22102868_ChIP-Seq_BL_Human1.79510807
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78856756
42ATF3_27146783_Chip-Seq_COLON_Human1.78459390
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77270430
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75263115
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74951255
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74951255
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74951255
48KDM2B_26808549_Chip-Seq_DND41_Human1.74627011
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74410840
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.70595670
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66043324
52KDM5A_27292631_Chip-Seq_BREAST_Human1.64108095
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64008906
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.63217463
55* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61222447
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61032090
57VDR_21846776_ChIP-Seq_THP-1_Human1.58651897
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.53882108
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.53818747
60* ARNT_22903824_ChIP-Seq_MCF-7_Human1.53528828
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52570741
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.51796244
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51715872
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50806801
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49926936
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49322475
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49078979
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.49066391
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48917022
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48822224
71GATA4_21415370_ChIP-Seq_HL-1_Mouse1.47589393
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47427686
73* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45845440
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42475953
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41043898
76TCF7_22412390_ChIP-Seq_EML_Mouse1.41030121
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40952926
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40931069
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39876019
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38752124
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38535660
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.38216601
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36508517
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35831602
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35333180
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35325152
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34524495
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34234375
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33538033
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33510933
91KDM2B_26808549_Chip-Seq_K562_Human1.33377805
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32535792
93CJUN_26792858_Chip-Seq_BT549_Human1.31462343
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30492354
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.30330569
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30276009
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30119096
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28244859
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28244859
100TP53_22127205_ChIP-Seq_IMR90_Human1.27974262
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27805430
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27325931
103CREB1_26743006_Chip-Seq_LNCaP_Human1.27186025
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26982068
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26838568
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26044345
107* TBX20_22080862_ChIP-Seq_HEART_Mouse1.25959602
108* TBX20_22328084_ChIP-Seq_HEART_Mouse1.25959602
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.24603461
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24461068
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21578413
112CIITA_25753668_ChIP-Seq_RAJI_Human1.20978238
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.20445877
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.18963413
115AR_21909140_ChIP-Seq_LNCAP_Human1.17073823
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16781318
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16280468
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16280468
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16176279
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15596518
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15503960
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13037568
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12937468
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11876260
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11622772
126CHD1_26751641_Chip-Seq_LNCaP_Human1.11518112
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11057917
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10682531
129SOX17_20123909_ChIP-Seq_XEN_Mouse1.09701312
130TP53_23651856_ChIP-Seq_MEFs_Mouse1.09654904
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09572433
132UBF1/2_26484160_Chip-Seq_HMECs_Human1.09360918
133E2F7_22180533_ChIP-Seq_HELA_Human1.08562022
134NCOR1_26117541_ChIP-Seq_K562_Human1.08067262
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07755309
136ESR1_21235772_ChIP-Seq_MCF-7_Human1.06971795
137PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06485014
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04804667
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04631210
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04301592
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03227580
142NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02639321
143GATA6_25053715_ChIP-Seq_YYC3_Human1.01873057
144SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01032962
145P68_20966046_ChIP-Seq_HELA_Human1.00469056
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98436165
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94194111
148* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93258755
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92654878
150EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92124752
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91347889
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91309780
153FOXA2_19822575_ChIP-Seq_HepG2_Human0.90976325
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89692553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.05683460
2MP0008438_abnormal_cutaneous_collagen4.58959628
3MP0004272_abnormal_basement_membrane2.67723911
4MP0005275_abnormal_skin_tensile2.53716577
5MP0003566_abnormal_cell_adhesion2.27684208
6MP0005623_abnormal_meninges_morphology2.15125582
7MP0004185_abnormal_adipocyte_glucose2.14790248
8MP0010352_gastrointestinal_tract_polyps2.12635933
9MP0002139_abnormal_hepatobiliary_system2.11005918
10MP0005360_urolithiasis2.00011506
11MP0000537_abnormal_urethra_morphology1.97765323
12MP0003941_abnormal_skin_development1.96924788
13MP0002009_preneoplasia1.91991043
14MP0005666_abnormal_adipose_tissue1.85828733
15MP0005076_abnormal_cell_differentiation1.84223868
16MP0009053_abnormal_anal_canal1.83628276
17MP0010030_abnormal_orbit_morphology1.82563765
18MP0000733_abnormal_muscle_development1.72598936
19MP0001958_emphysema1.72019869
20MP0003279_aneurysm1.67979832
21MP0009840_abnormal_foam_cell1.67828158
22MP0002108_abnormal_muscle_morphology1.60921028
23MP0005503_abnormal_tendon_morphology1.59044548
24MP0005375_adipose_tissue_phenotype1.58621380
25MP0008057_abnormal_DNA_replication1.58571214
26MP0006054_spinal_hemorrhage1.58407724
27MP0003283_abnormal_digestive_organ1.54525799
28MP0000569_abnormal_digit_pigmentation1.53587861
29MP0002938_white_spotting1.53446461
30MP0005670_abnormal_white_adipose1.53425691
31MP0009780_abnormal_chondrocyte_physiolo1.50470579
32MP0003937_abnormal_limbs/digits/tail_de1.47733927
33MP0005023_abnormal_wound_healing1.46019356
34MP0000003_abnormal_adipose_tissue1.44066590
35MP0009250_abnormal_appendicular_skeleto1.42873119
36MP0001299_abnormal_eye_distance/1.40181530
37MP0003300_gastrointestinal_ulcer1.36803004
38MP0010234_abnormal_vibrissa_follicle1.36472731
39MP0005083_abnormal_biliary_tract1.36312956
40MP0009384_cardiac_valve_regurgitation1.36070409
41MP0002254_reproductive_system_inflammat1.35550839
42MP0004130_abnormal_muscle_cell1.35032985
43MP0002877_abnormal_melanocyte_morpholog1.32966603
44MP0004087_abnormal_muscle_fiber1.30951458
45MP0010368_abnormal_lymphatic_system1.28625542
46MP0004084_abnormal_cardiac_muscle1.28320279
47MP0001849_ear_inflammation1.28273919
48MP0005365_abnormal_bile_salt1.26940089
49MP0003115_abnormal_respiratory_system1.26528202
50MP0010329_abnormal_lipoprotein_level1.26038810
51MP0000751_myopathy1.24608620
52* MP0004197_abnormal_fetal_growth/weight/1.24531775
53MP0003191_abnormal_cellular_cholesterol1.24242813
54MP0003252_abnormal_bile_duct1.24185300
55MP0003091_abnormal_cell_migration1.24029660
56MP0004264_abnormal_extraembryonic_tissu1.22483166
57MP0000750_abnormal_muscle_regeneration1.22382102
58MP0000432_abnormal_head_morphology1.21692824
59MP0003567_abnormal_fetal_cardiomyocyte1.19663399
60MP0005257_abnormal_intraocular_pressure1.19349740
61MP0010630_abnormal_cardiac_muscle1.17513739
62MP0003890_abnormal_embryonic-extraembry1.17348888
63MP0004233_abnormal_muscle_weight1.16882118
64MP0000428_abnormal_craniofacial_morphol1.16245061
65MP0003385_abnormal_body_wall1.13363262
66MP0003950_abnormal_plasma_membrane1.12308498
67MP0003942_abnormal_urinary_system1.12143098
68MP0003806_abnormal_nucleotide_metabolis1.12090856
69MP0003935_abnormal_craniofacial_develop1.08865176
70MP0003755_abnormal_palate_morphology1.08698896
71MP0000534_abnormal_ureter_morphology1.08007636
72MP0000013_abnormal_adipose_tissue1.07837779
73MP0001542_abnormal_bone_strength1.07761344
74MP0009703_decreased_birth_body1.07203185
75MP0001293_anophthalmia1.06651868
76MP0001730_embryonic_growth_arrest1.06223939
77MP0003123_paternal_imprinting1.05510112
78MP0002269_muscular_atrophy1.05254593
79MP0002060_abnormal_skin_morphology1.05081856
80MP0002837_dystrophic_cardiac_calcinosis1.04974442
81MP0002116_abnormal_craniofacial_bone1.04180461
82MP0001915_intracranial_hemorrhage1.03142223
83MP0000747_muscle_weakness1.03087897
84MP0002896_abnormal_bone_mineralization1.02795317
85MP0001243_abnormal_dermal_layer1.00346370
86MP0004134_abnormal_chest_morphology0.99403281
87MP0005085_abnormal_gallbladder_physiolo0.97344008
88MP0001661_extended_life_span0.97071775
89MP0002697_abnormal_eye_size0.95519205
90MP0002084_abnormal_developmental_patter0.95386823
91MP0003119_abnormal_digestive_system0.94938494
92* MP0002086_abnormal_extraembryonic_tissu0.94480577
93MP0006138_congestive_heart_failure0.94429027
94* MP0002088_abnormal_embryonic_growth/wei0.93897177
95MP0005508_abnormal_skeleton_morphology0.93451550
96MP0002114_abnormal_axial_skeleton0.93248733
97MP0005330_cardiomyopathy0.92949981
98* MP0003984_embryonic_growth_retardation0.92869141
99MP0009278_abnormal_bone_marrow0.91616303
100MP0009672_abnormal_birth_weight0.91241116
101MP0002127_abnormal_cardiovascular_syste0.91223350
102MP0002115_abnormal_skeleton_extremities0.90556877
103MP0002233_abnormal_nose_morphology0.90416298
104MP0002128_abnormal_blood_circulation0.90039915
105MP0000767_abnormal_smooth_muscle0.89999935
106MP0002925_abnormal_cardiovascular_devel0.89737572
107MP0001175_abnormal_lung_morphology0.89385870
108MP0002109_abnormal_limb_morphology0.89331763
109MP0003111_abnormal_nucleus_morphology0.89226084
110MP0002089_abnormal_postnatal_growth/wei0.88570208
111* MP0001672_abnormal_embryogenesis/_devel0.87582845
112* MP0005380_embryogenesis_phenotype0.87582845
113MP0010094_abnormal_chromosome_stability0.87481036
114MP0004858_abnormal_nervous_system0.87078127
115MP0005621_abnormal_cell_physiology0.86707397
116MP0002111_abnormal_tail_morphology0.86669172
117MP0002751_abnormal_autonomic_nervous0.86273145
118MP0000462_abnormal_digestive_system0.84742498
119MP0000759_abnormal_skeletal_muscle0.84613751
120MP0002085_abnormal_embryonic_tissue0.84597552
121MP0001340_abnormal_eyelid_morphology0.83408219
122MP0000350_abnormal_cell_proliferation0.83121834
123MP0001614_abnormal_blood_vessel0.82867402
124MP0008775_abnormal_heart_ventricle0.82855314
125MP0000609_abnormal_liver_physiology0.82274347
126MP0010307_abnormal_tumor_latency0.82159560
127MP0002396_abnormal_hematopoietic_system0.81989651
128MP0004808_abnormal_hematopoietic_stem0.81015437
129MP0000049_abnormal_middle_ear0.80830941
130MP0005058_abnormal_lysosome_morphology0.80237768
131MP0001286_abnormal_eye_development0.80230312
132MP0002295_abnormal_pulmonary_circulatio0.80212293
133MP0003221_abnormal_cardiomyocyte_apopto0.79976508
134MP0000266_abnormal_heart_morphology0.79817527
135MP0002932_abnormal_joint_morphology0.79647896
136MP0003077_abnormal_cell_cycle0.79435017
137MP0001544_abnormal_cardiovascular_syste0.79111832
138MP0005385_cardiovascular_system_phenoty0.79111832
139* MP0001697_abnormal_embryo_size0.77525299
140MP0002282_abnormal_trachea_morphology0.77319224
141MP0003453_abnormal_keratinocyte_physiol0.76277938
142MP0002092_abnormal_eye_morphology0.74325053

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.83084066
2Premature rupture of membranes (HP:0001788)4.47693620
3Shallow orbits (HP:0000586)3.94888161
4Cerebral aneurysm (HP:0004944)3.76176781
5Ankle contracture (HP:0006466)3.42536252
6Increased connective tissue (HP:0009025)3.22106679
7Deep venous thrombosis (HP:0002625)3.07013865
8Broad metatarsal (HP:0001783)2.98838826
9Lymphangioma (HP:0100764)2.96222778
10Bladder diverticulum (HP:0000015)2.83636033
11Mitral valve prolapse (HP:0001634)2.81465607
12Vascular tortuosity (HP:0004948)2.76400749
13Turricephaly (HP:0000262)2.70338631
14Upper limb amyotrophy (HP:0009129)2.69950874
15Distal upper limb amyotrophy (HP:0007149)2.69950874
16Peritonitis (HP:0002586)2.59815610
17Back pain (HP:0003418)2.59593313
18Neonatal short-limb short stature (HP:0008921)2.59079611
19Arterial tortuosity (HP:0005116)2.53947006
20Aneurysm (HP:0002617)2.51807299
21Difficulty climbing stairs (HP:0003551)2.48373462
22Abnormality of the Achilles tendon (HP:0005109)2.48339491
23Achilles tendon contracture (HP:0001771)2.45325918
24Ulnar bowing (HP:0003031)2.44326337
25Spinal cord lesions (HP:0100561)2.44023006
26Syringomyelia (HP:0003396)2.44023006
27Hand muscle atrophy (HP:0009130)2.42327220
28Aortic dissection (HP:0002647)2.40921285
29Cervical subluxation (HP:0003308)2.40282941
30Right ventricular cardiomyopathy (HP:0011663)2.39713493
31Type 1 muscle fiber predominance (HP:0003803)2.39161776
32Hyporeflexia of lower limbs (HP:0002600)2.37629311
33Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.34519826
34Xanthomatosis (HP:0000991)2.32629523
35Hyperacusis (HP:0010780)2.32142861
36Genu recurvatum (HP:0002816)2.32135738
37Joint laxity (HP:0001388)2.31790718
38Increased variability in muscle fiber diameter (HP:0003557)2.28267796
39Spinal rigidity (HP:0003306)2.27618438
40Scapular winging (HP:0003691)2.23675795
41Morphological abnormality of the middle ear (HP:0008609)2.22627383
42Difficulty running (HP:0009046)2.21742928
43Blue sclerae (HP:0000592)2.20676545
44Long toe (HP:0010511)2.19455520
45Thin bony cortex (HP:0002753)2.18379329
46Dilatation of the ascending aorta (HP:0005111)2.17337483
47Spastic diplegia (HP:0001264)2.16902052
48Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16011919
49Atrophic scars (HP:0001075)2.15990664
50Bowel diverticulosis (HP:0005222)2.14030504
51Aortic aneurysm (HP:0004942)2.13382154
52Deviation of the hallux (HP:0010051)2.12416421
53High anterior hairline (HP:0009890)2.12318173
54Abnormality of the 4th metacarpal (HP:0010012)2.10719569
55Buphthalmos (HP:0000557)2.10554063
56Biconcave vertebral bodies (HP:0004586)2.10077123
57Long eyelashes (HP:0000527)2.09869736
58Renal duplication (HP:0000075)2.08483963
59Skull defect (HP:0001362)2.07292530
60Rectal prolapse (HP:0002035)2.07040891
61Hallux valgus (HP:0001822)2.06019784
62Absent frontal sinuses (HP:0002688)2.05647361
63Abnormal cartilage morphology (HP:0002763)2.04422773
64Breech presentation (HP:0001623)2.04142239
65Mildly elevated creatine phosphokinase (HP:0008180)2.03159356
66Broad long bones (HP:0005622)2.02942448
67Muscle fiber splitting (HP:0003555)2.01678997
68Infantile muscular hypotonia (HP:0008947)2.01327285
69Enlarged penis (HP:0000040)2.00405216
70Abnormality of skeletal muscle fiber size (HP:0012084)1.99562981
71Wrist flexion contracture (HP:0001239)1.99545207
72Camptodactyly of toe (HP:0001836)1.98598061
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98141919
74Short 4th metacarpal (HP:0010044)1.98141919
75Soft skin (HP:0000977)1.96349255
76Follicular hyperkeratosis (HP:0007502)1.93914542
77Premature skin wrinkling (HP:0100678)1.93046966
78Urethral obstruction (HP:0000796)1.92064381
79Fragile skin (HP:0001030)1.91893278
80Flat cornea (HP:0007720)1.89136293
81Multiple enchondromatosis (HP:0005701)1.87439679
82Bowed forearm bones (HP:0003956)1.87385325
83Bowing of the arm (HP:0006488)1.87385325
84Renovascular hypertension (HP:0100817)1.86867901
85Fibroma (HP:0010614)1.86150430
86Abnormality of dentin (HP:0010299)1.85268775
87High pitched voice (HP:0001620)1.84987492
88Broad phalanx (HP:0006009)1.84453720
89Hypoventilation (HP:0002791)1.83632862
90Hyperextensible skin (HP:0000974)1.83609567
91Wormian bones (HP:0002645)1.83371676
92Coronal craniosynostosis (HP:0004440)1.82939246
93Subacute progressive viral hepatitis (HP:0006572)1.81755334
94Abnormality of the epiphyses of the hand (HP:0005924)1.81515833
95Pseudobulbar signs (HP:0002200)1.81332693
96Skin nodule (HP:0200036)1.80726404
97Metaphyseal cupping (HP:0003021)1.79970337
98Visceral angiomatosis (HP:0100761)1.79677647
99Selective tooth agenesis (HP:0001592)1.79667786
100Round ear (HP:0100830)1.79582360
101Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.79130595
102Narrow palate (HP:0000189)1.79101132
103Abnormality of the radial head (HP:0003995)1.78637628
104Abnormality of the frontal sinuses (HP:0002687)1.78328065
105Cardiovascular calcification (HP:0011915)1.78106854
106Smooth philtrum (HP:0000319)1.77655998
107Asymmetry of the thorax (HP:0001555)1.76215143
108Fibrous tissue neoplasm (HP:0012316)1.76019498
109Hypoalphalipoproteinemia (HP:0003233)1.75735713
110Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75446831
111Myoglobinuria (HP:0002913)1.75184686
112Exostoses (HP:0100777)1.75175465
113Inguinal hernia (HP:0000023)1.75097422
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73758402
115Radial bowing (HP:0002986)1.73699473
116Vertebral arch anomaly (HP:0008438)1.73484036
117Bronchomalacia (HP:0002780)1.73212966
118Broad phalanges of the hand (HP:0009768)1.73211843
119Disproportionate tall stature (HP:0001519)1.73124169
120Broad thumb (HP:0011304)1.73105011
121Angiofibromas (HP:0010615)1.72867095
122Adenoma sebaceum (HP:0009720)1.72867095
123Broad finger (HP:0001500)1.72785757
124Spondylolisthesis (HP:0003302)1.72683618
125Abnormality of the aortic arch (HP:0012303)1.71344595
126Increased density of long bones (HP:0006392)1.71070571
127Myocardial infarction (HP:0001658)1.69762358
128Elfin facies (HP:0004428)1.69563723
129Mesangial abnormality (HP:0001966)1.69180365
130Abnormality of the calcaneus (HP:0008364)1.68874646
131Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68816073
132Hemangiomatosis (HP:0007461)1.68651615
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.67284569
134Wide anterior fontanel (HP:0000260)1.66364956
135Overgrowth (HP:0001548)1.66017408
136Dislocated radial head (HP:0003083)1.65911518
137Elbow flexion contracture (HP:0002987)1.65565020
138Acanthosis nigricans (HP:0000956)1.64905359
139Abnormality of the acetabulum (HP:0003170)1.64796162
140Short nail (HP:0001799)1.64720459
141Natal tooth (HP:0000695)1.64474950
142Exercise-induced muscle cramps (HP:0003710)1.63314002
143Arnold-Chiari malformation (HP:0002308)1.63007618
144Osteolytic defects of the hand bones (HP:0009699)1.60361989
145Macroorchidism (HP:0000053)1.60138935
146Abnormal delivery (HP:0001787)1.59029699
147Aortic regurgitation (HP:0001659)1.58890629
148Delayed cranial suture closure (HP:0000270)1.58318175
149Mild short stature (HP:0003502)1.58235782
150Mitral regurgitation (HP:0001653)1.58044666
151Pes planus (HP:0001763)1.57007655
152Patellar dislocation (HP:0002999)1.56496573
153Rhizomelia (HP:0008905)1.56238337
154Abnormality of the phalanges of the hallux (HP:0010057)1.54818530
155Broad face (HP:0000283)1.51088499
156Entropion (HP:0000621)1.50051959
157Mitral stenosis (HP:0001718)1.49582439
158Abnormality of skull ossification (HP:0002703)1.49485033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.73489673
2PKN24.44209024
3EEF2K2.96944655
4TTN2.92295640
5MAP3K102.63496727
6PDGFRA2.45660188
7LATS12.43450178
8ERN12.40247958
9SIK12.26444083
10RIPK12.25681638
11PTK62.17013498
12AKT32.04538283
13DDR22.02555398
14ICK1.89068185
15PRKD21.77904190
16LATS21.77250378
17BMX1.73772494
18EPHB21.72965299
19LRRK21.69526228
20BCKDK1.52325398
21BRD41.49343901
22SCYL21.45135456
23MET1.44184001
24PAK41.42229357
25SMG11.40282283
26PTK21.33715994
27STK391.33341493
28MTOR1.32887906
29SRPK11.30282073
30TRPM71.29760169
31CDK121.27878785
32PAK21.27450988
33ILK1.26641089
34LMTK21.18778423
35EPHA21.16899426
36MAP3K61.16228975
37WNK11.15748678
38FLT31.13978966
39FER1.09274123
40NEK11.06967356
41PRKD31.04697749
42CAMK1D1.03893689
43EPHB11.03397623
44MAP2K31.00772346
45RPS6KB20.99857773
46FGFR40.98736320
47CDK60.98686098
48ERBB40.97823931
49TYRO30.96959032
50RET0.96027980
51MAP3K80.96027532
52NEK20.90259208
53FGFR10.90085406
54ALK0.89036052
55STK30.88493200
56KSR20.87692106
57PDGFRB0.84886852
58STK380.84374843
59TLK10.84341476
60MKNK10.83694196
61PIK3CA0.83691626
62CDK30.80478970
63MELK0.79017878
64TESK10.76609422
65DMPK0.74190064
66RPS6KB10.72724198
67STK100.72637624
68MYLK0.71998693
69CHUK0.70161798
70PRKAA10.70084137
71CHEK10.69899405
72ATR0.68042958
73TGFBR10.67519825
74DAPK30.66946804
75CAMK1G0.66944242
76MKNK20.66175992
77CDK90.65813916
78CDK40.65796614
79DYRK1B0.64738721
80MAP2K10.64367746
81MAP2K20.63919137
82MST1R0.62993031
83NEK90.62306356
84CHEK20.60863474
85MAP3K30.59452172
86PAK30.59229579
87RPS6KC10.59028838
88RPS6KL10.59028838
89CDK80.58557498
90RPS6KA40.58035235
91PRKD10.56766154
92FGFR30.55542673
93FGFR20.55356168
94PDK30.53893990
95PDK40.53893990
96GSK3A0.53717229
97RPS6KA60.52943526
98INSRR0.52455615
99MAP3K140.52288069
100ATM0.51927231
101MAPKAPK30.51888911
102PASK0.51661760
103NTRK10.51571418
104MAP3K110.51134847
105AKT20.50768032
106CLK10.50585385
107ROCK10.50352423
108ERBB20.50144969
109LIMK10.49919591
110HIPK20.48016748
111AURKB0.46968209
112EPHA30.46539972
113ROCK20.46310123
114ZAK0.46000457
115MAPK70.45856021
116KDR0.45819394
117TAOK10.44134592
118PTK2B0.43725563
119PAK60.43353259
120WNK40.42443322
121TESK20.42220087
122TGFBR20.41396951
123CDK10.40939554
124MAPK90.39530535
125PAK10.38946249
126MAPK10.38240330
127CDK20.36347099
128PINK10.36266510
129BMPR1B0.36157880
130STK38L0.33945081
131KIT0.33800649
132RPS6KA10.33009717
133TTK0.32754911
134MAPK110.32466669
135MAP3K20.32427518
136RPS6KA20.32401743
137INSR0.31676251
138MAP3K70.30833360
139CDK70.30184780
140PRKG20.29501650
141CDC42BPA0.29267569
142CAMKK10.29246433
143TIE10.28537893
144PRKCH0.28380383
145SRC0.27607537

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.80101615
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.63370948
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32166695
4Fatty acid degradation_Homo sapiens_hsa000712.18821960
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97219263
6Arginine biosynthesis_Homo sapiens_hsa002201.96065166
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95290821
8Fatty acid metabolism_Homo sapiens_hsa012121.90363998
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89820767
10PPAR signaling pathway_Homo sapiens_hsa033201.88928125
11ECM-receptor interaction_Homo sapiens_hsa045121.78237266
12Propanoate metabolism_Homo sapiens_hsa006401.72001916
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71446671
14Carbon metabolism_Homo sapiens_hsa012001.70486339
15Bladder cancer_Homo sapiens_hsa052191.65367367
16Biosynthesis of amino acids_Homo sapiens_hsa012301.62785924
17Focal adhesion_Homo sapiens_hsa045101.61934003
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.55031736
19Colorectal cancer_Homo sapiens_hsa052101.52006202
20Selenocompound metabolism_Homo sapiens_hsa004501.50577752
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48978221
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.48123410
23Non-homologous end-joining_Homo sapiens_hsa034501.47927947
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45640441
25Lysine degradation_Homo sapiens_hsa003101.44790310
26Proteoglycans in cancer_Homo sapiens_hsa052051.41997680
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.38237808
28Fatty acid biosynthesis_Homo sapiens_hsa000611.37289073
29Tryptophan metabolism_Homo sapiens_hsa003801.34671438
30Chronic myeloid leukemia_Homo sapiens_hsa052201.31506055
31Hippo signaling pathway_Homo sapiens_hsa043901.30084300
32One carbon pool by folate_Homo sapiens_hsa006701.28471236
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26389964
34Adherens junction_Homo sapiens_hsa045201.26296200
35Small cell lung cancer_Homo sapiens_hsa052221.25990067
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25926911
37Pyruvate metabolism_Homo sapiens_hsa006201.24359836
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23827365
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21347465
40mRNA surveillance pathway_Homo sapiens_hsa030151.18893909
41Sulfur relay system_Homo sapiens_hsa041221.18529020
42Complement and coagulation cascades_Homo sapiens_hsa046101.16527265
43Basal cell carcinoma_Homo sapiens_hsa052171.13948891
44Amoebiasis_Homo sapiens_hsa051461.13765286
45Butanoate metabolism_Homo sapiens_hsa006501.13000431
46Insulin resistance_Homo sapiens_hsa049311.12060484
47Fanconi anemia pathway_Homo sapiens_hsa034601.12049122
48Base excision repair_Homo sapiens_hsa034101.12023009
49AMPK signaling pathway_Homo sapiens_hsa041521.10986898
50Fat digestion and absorption_Homo sapiens_hsa049751.10831108
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.07384394
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06291266
53RNA transport_Homo sapiens_hsa030131.06199623
54Circadian rhythm_Homo sapiens_hsa047101.06010455
55Tight junction_Homo sapiens_hsa045301.05939632
56N-Glycan biosynthesis_Homo sapiens_hsa005101.04918796
57Bile secretion_Homo sapiens_hsa049761.03139333
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01440491
59Cell cycle_Homo sapiens_hsa041100.99321160
60Wnt signaling pathway_Homo sapiens_hsa043100.98338278
61mTOR signaling pathway_Homo sapiens_hsa041500.96480380
62MicroRNAs in cancer_Homo sapiens_hsa052060.92743237
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91502880
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91162007
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90433741
66Choline metabolism in cancer_Homo sapiens_hsa052310.88647105
67p53 signaling pathway_Homo sapiens_hsa041150.87592518
68Insulin signaling pathway_Homo sapiens_hsa049100.87075751
69Inositol phosphate metabolism_Homo sapiens_hsa005620.86273397
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86035502
71Dilated cardiomyopathy_Homo sapiens_hsa054140.84175758
72* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84061156
73Hedgehog signaling pathway_Homo sapiens_hsa043400.82194859
74Endometrial cancer_Homo sapiens_hsa052130.81499473
75beta-Alanine metabolism_Homo sapiens_hsa004100.81316935
76Protein digestion and absorption_Homo sapiens_hsa049740.81215026
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81180847
78Nucleotide excision repair_Homo sapiens_hsa034200.80782758
79Viral myocarditis_Homo sapiens_hsa054160.80333106
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79618420
81Other glycan degradation_Homo sapiens_hsa005110.79209465
82Prolactin signaling pathway_Homo sapiens_hsa049170.79069733
83Thyroid cancer_Homo sapiens_hsa052160.78989949
84TGF-beta signaling pathway_Homo sapiens_hsa043500.78421287
85Axon guidance_Homo sapiens_hsa043600.78057019
86Renal cell carcinoma_Homo sapiens_hsa052110.77400690
87Notch signaling pathway_Homo sapiens_hsa043300.76905418
88ErbB signaling pathway_Homo sapiens_hsa040120.76377195
89Melanogenesis_Homo sapiens_hsa049160.75515057
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74986432
91Phenylalanine metabolism_Homo sapiens_hsa003600.74931339
92Basal transcription factors_Homo sapiens_hsa030220.74910302
93FoxO signaling pathway_Homo sapiens_hsa040680.73137843
94Arginine and proline metabolism_Homo sapiens_hsa003300.72116261
95Starch and sucrose metabolism_Homo sapiens_hsa005000.71446227
96Glioma_Homo sapiens_hsa052140.71131712
97VEGF signaling pathway_Homo sapiens_hsa043700.70874780
98Glycerolipid metabolism_Homo sapiens_hsa005610.69885328
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69079022
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68550928
101Non-small cell lung cancer_Homo sapiens_hsa052230.68091511
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65427501
103Pentose phosphate pathway_Homo sapiens_hsa000300.64952933
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.63327941
105Hepatitis B_Homo sapiens_hsa051610.63189489
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.62714242
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62650035
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62552231
109Peroxisome_Homo sapiens_hsa041460.62284541
110Glucagon signaling pathway_Homo sapiens_hsa049220.61907676
111HTLV-I infection_Homo sapiens_hsa051660.61790568
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61131368
113DNA replication_Homo sapiens_hsa030300.60385136
114Spliceosome_Homo sapiens_hsa030400.60258097
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60203728
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.58628518
117Pancreatic cancer_Homo sapiens_hsa052120.58567593
118HIF-1 signaling pathway_Homo sapiens_hsa040660.54958113
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54880233
120Acute myeloid leukemia_Homo sapiens_hsa052210.54152283
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53448942
122Prostate cancer_Homo sapiens_hsa052150.53198442
123Steroid biosynthesis_Homo sapiens_hsa001000.52261155
124Alcoholism_Homo sapiens_hsa050340.52239280
125Viral carcinogenesis_Homo sapiens_hsa052030.51091895
126Thyroid hormone synthesis_Homo sapiens_hsa049180.50787379
127Tyrosine metabolism_Homo sapiens_hsa003500.50441158
128Melanoma_Homo sapiens_hsa052180.50247024
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49684425
130Caffeine metabolism_Homo sapiens_hsa002320.47773546
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47282498
132Homologous recombination_Homo sapiens_hsa034400.46584508
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.46198729
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46048640
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45947577
136Pathways in cancer_Homo sapiens_hsa052000.45674019
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44437458
138Systemic lupus erythematosus_Homo sapiens_hsa053220.44246866
139Estrogen signaling pathway_Homo sapiens_hsa049150.42272156
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41289137

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »