FBXW9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.22937374
2cilium movement (GO:0003341)5.21693030
3epithelial cilium movement (GO:0003351)5.03988197
4cilium or flagellum-dependent cell motility (GO:0001539)4.77032785
5motile cilium assembly (GO:0044458)4.76381119
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64475468
7L-phenylalanine metabolic process (GO:0006558)4.64475468
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.55886645
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.54011102
10L-phenylalanine catabolic process (GO:0006559)4.47376198
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47376198
12regulation of podosome assembly (GO:0071801)4.44811811
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.44119781
14negative regulation of peptidyl-lysine acetylation (GO:2000757)4.31132168
15GTP biosynthetic process (GO:0006183)4.28503425
16left/right pattern formation (GO:0060972)4.25894047
17negative regulation of fibrinolysis (GO:0051918)4.17646080
18base-excision repair, AP site formation (GO:0006285)4.16656309
19serine family amino acid catabolic process (GO:0009071)4.11437895
20UTP biosynthetic process (GO:0006228)4.01901127
21pyrimidine nucleobase catabolic process (GO:0006208)4.01331406
22negative regulation of protein acetylation (GO:1901984)4.00976087
23rRNA modification (GO:0000154)4.00208099
24guanosine-containing compound biosynthetic process (GO:1901070)3.99859132
25GDP-mannose metabolic process (GO:0019673)3.99604550
26glycine metabolic process (GO:0006544)3.95076525
27aromatic amino acid family catabolic process (GO:0009074)3.91420994
28regulation of mitochondrial translation (GO:0070129)3.87683030
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84928276
30regulation of fibrinolysis (GO:0051917)3.83239028
31peptidyl-arginine omega-N-methylation (GO:0035247)3.82986191
32intraciliary transport (GO:0042073)3.75605231
33protein insertion into membrane (GO:0051205)3.74336310
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.73195330
35UTP metabolic process (GO:0046051)3.72413692
36sulfur amino acid catabolic process (GO:0000098)3.70897666
37glyoxylate metabolic process (GO:0046487)3.68999030
38purine nucleobase biosynthetic process (GO:0009113)3.68899977
39pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.67268846
40urea cycle (GO:0000050)3.67243753
41urea metabolic process (GO:0019627)3.67243753
42deoxyribonucleotide catabolic process (GO:0009264)3.64889551
43pyrimidine nucleotide catabolic process (GO:0006244)3.61533481
44CTP biosynthetic process (GO:0006241)3.57663810
45CTP metabolic process (GO:0046036)3.57663810
46pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.57561075
47folic acid transport (GO:0015884)3.54201018
48cysteine metabolic process (GO:0006534)3.53385192
49negative regulation of histone acetylation (GO:0035067)3.52015343
50interferon-gamma secretion (GO:0072643)3.51631914
51chaperone-mediated protein transport (GO:0072321)3.47048259
52protein complex biogenesis (GO:0070271)3.46369914
53folic acid metabolic process (GO:0046655)3.44274643
54metallo-sulfur cluster assembly (GO:0031163)3.43118912
55iron-sulfur cluster assembly (GO:0016226)3.43118912
56pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.42386573
57protein maturation by protein folding (GO:0022417)3.41813558
58deoxyribose phosphate catabolic process (GO:0046386)3.40488085
59bile acid biosynthetic process (GO:0006699)3.40160569
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40046198
61serine family amino acid metabolic process (GO:0009069)3.39314562
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.38341377
63axoneme assembly (GO:0035082)3.38214939
64peptidyl-glutamic acid carboxylation (GO:0017187)3.36937441
65protein carboxylation (GO:0018214)3.36937441
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36528606
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.36528606
68NADH dehydrogenase complex assembly (GO:0010257)3.36528606
69nitrogen cycle metabolic process (GO:0071941)3.36201421
70indole-containing compound catabolic process (GO:0042436)3.35388857
71indolalkylamine catabolic process (GO:0046218)3.35388857
72tryptophan catabolic process (GO:0006569)3.35388857
73regulation of cilium movement (GO:0003352)3.34885303
74high-density lipoprotein particle remodeling (GO:0034375)3.34039956
75nucleoside diphosphate phosphorylation (GO:0006165)3.32966861
76mitochondrial respiratory chain complex assembly (GO:0033108)3.32958280
77base-excision repair (GO:0006284)3.30969033
78DNA deamination (GO:0045006)3.30335889
79imidazole-containing compound metabolic process (GO:0052803)3.29291408
80negative regulation of sterol transport (GO:0032372)3.28376120
81negative regulation of cholesterol transport (GO:0032375)3.28376120
82regulation of hippo signaling (GO:0035330)3.27983401
83oxidative phosphorylation (GO:0006119)3.27838494
84epoxygenase P450 pathway (GO:0019373)3.27584707
85kynurenine metabolic process (GO:0070189)3.27050294
86gastrulation with mouth forming second (GO:0001702)3.26649681
87telomere maintenance via semi-conservative replication (GO:0032201)3.24336010
88nucleobase biosynthetic process (GO:0046112)3.23857336
89pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.23791334
90tryptophan metabolic process (GO:0006568)3.23107560
91homocysteine metabolic process (GO:0050667)3.21661213
92serine family amino acid biosynthetic process (GO:0009070)3.20269053
93histone arginine methylation (GO:0034969)3.20119505
94purine deoxyribonucleotide catabolic process (GO:0009155)3.19648470
95nucleobase catabolic process (GO:0046113)3.18411978
96aromatic amino acid family metabolic process (GO:0009072)3.18091004
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16976326
98spliceosomal snRNP assembly (GO:0000387)3.16947324
99ATP synthesis coupled proton transport (GO:0015986)3.16791314
100energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16791314
101ribosomal small subunit assembly (GO:0000028)3.14182645
102DNA strand elongation involved in DNA replication (GO:0006271)3.12008428
103peptidyl-arginine methylation (GO:0018216)3.11736885
104peptidyl-arginine N-methylation (GO:0035246)3.11736885
105regulation of protein activation cascade (GO:2000257)3.09731881
106drug catabolic process (GO:0042737)3.08615813
107lung-associated mesenchyme development (GO:0060484)3.08544989
108establishment of integrated proviral latency (GO:0075713)3.07118930
109regulation of gene silencing by RNA (GO:0060966)3.06595333
110regulation of posttranscriptional gene silencing (GO:0060147)3.06595333
111regulation of gene silencing by miRNA (GO:0060964)3.06595333
112cullin deneddylation (GO:0010388)3.05924373
113proteasome assembly (GO:0043248)3.05137517
114alpha-linolenic acid metabolic process (GO:0036109)3.04946912
115paraxial mesoderm development (GO:0048339)3.04387161
116response to pheromone (GO:0019236)3.03947286
117regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.03686356
118peptidyl-histidine modification (GO:0018202)3.02020827
119DNA strand elongation (GO:0022616)3.01276155
120amino-acid betaine metabolic process (GO:0006577)2.99500656
1212-deoxyribonucleotide metabolic process (GO:0009394)2.99206929
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.98082146
123regulation of cellular amino acid metabolic process (GO:0006521)2.97644703
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96990173
125ribosome assembly (GO:0042255)2.96692605
126reverse cholesterol transport (GO:0043691)2.96373574
127establishment of viral latency (GO:0019043)2.96273241
128negative regulation of ligase activity (GO:0051352)2.94342389
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94342389
130protein deneddylation (GO:0000338)2.94254109
131regulation of cholesterol esterification (GO:0010872)2.93009978
132folic acid-containing compound biosynthetic process (GO:0009396)2.92745553
133negative regulation of B cell apoptotic process (GO:0002903)2.92487180
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90194120
135arginine metabolic process (GO:0006525)2.89652232
136fibrinolysis (GO:0042730)2.88553143
137microtubule depolymerization (GO:0007019)2.88029346
138regulation of complement activation (GO:0030449)2.87512362
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86432432
140regulation of plasminogen activation (GO:0010755)2.86280654
141transcription-coupled nucleotide-excision repair (GO:0006283)2.86266884
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85294323
143alpha-amino acid catabolic process (GO:1901606)2.85142956
144tyrosine metabolic process (GO:0006570)2.85073666
145bile acid metabolic process (GO:0008206)2.84780268
146negative regulation of DNA-templated transcription, elongation (GO:0032785)2.84290411
147proline biosynthetic process (GO:0006561)2.83185232
148lipopolysaccharide biosynthetic process (GO:0009103)2.82639413
149mitochondrial calcium ion transport (GO:0006851)2.81687918
150mitotic nuclear envelope reassembly (GO:0007084)2.81554706
151nuclear envelope reassembly (GO:0031468)2.81554706
152aldehyde catabolic process (GO:0046185)2.81170233
153pseudouridine synthesis (GO:0001522)2.79660768
154cellular glucuronidation (GO:0052695)2.79446315
155deoxyribose phosphate metabolic process (GO:0019692)2.78624178
156acylglycerol homeostasis (GO:0055090)2.78271267
157triglyceride homeostasis (GO:0070328)2.78271267
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76702184
159cellular ketone body metabolic process (GO:0046950)2.76437607
160deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76153681
161DNA strand renaturation (GO:0000733)2.75693779
162GMP metabolic process (GO:0046037)2.72710376
163rRNA methylation (GO:0031167)2.72638477
164intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69429141
165signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69429141
166folic acid-containing compound metabolic process (GO:0006760)2.68961614
167electron transport chain (GO:0022900)2.68875255
168galactose catabolic process (GO:0019388)2.67835584
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66897217
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66897217
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66897217
172transcription elongation from RNA polymerase III promoter (GO:0006385)2.66883410
173termination of RNA polymerase III transcription (GO:0006386)2.66883410
174establishment of apical/basal cell polarity (GO:0035089)2.66669894
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.64496933
176establishment of monopolar cell polarity (GO:0061162)2.64496933
177tetrahydrofolate metabolic process (GO:0046653)2.64088347
178basement membrane organization (GO:0071711)2.63744300
179chaperone-mediated protein complex assembly (GO:0051131)2.62606618
180formation of translation preinitiation complex (GO:0001731)2.62102064
181plasma lipoprotein particle clearance (GO:0034381)2.59959620
182cellular amino acid catabolic process (GO:0009063)2.59500864
183cellular modified amino acid catabolic process (GO:0042219)2.57759589
184response to nitrosative stress (GO:0051409)2.56650099
185plasma lipoprotein particle remodeling (GO:0034369)2.55972569
186protein-lipid complex remodeling (GO:0034368)2.55972569
187macromolecular complex remodeling (GO:0034367)2.55972569
188one-carbon metabolic process (GO:0006730)2.55350109
189regulation of cholesterol homeostasis (GO:2000188)2.54362373
190intestinal cholesterol absorption (GO:0030299)2.54345087
191regulation of bile acid biosynthetic process (GO:0070857)2.52623770
192L-serine metabolic process (GO:0006563)2.52223876
193L-ascorbic acid metabolic process (GO:0019852)2.52017585
194drug metabolic process (GO:0017144)2.49536523
195modified amino acid transport (GO:0072337)2.48990541
196complement activation, alternative pathway (GO:0006957)2.48445466
197coenzyme catabolic process (GO:0009109)2.47244919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03225007
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.60867177
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.52575992
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48410717
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.15226272
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13369841
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.08883111
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.01264766
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.88133864
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.80251105
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.71278918
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57682038
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53485616
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47850880
15STAT3_1855785_ChIP-Seq_MESCs_Mouse2.36549446
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.32637127
17NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32463729
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32158601
19ZNF263_19887448_ChIP-Seq_K562_Human2.28904950
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.26752006
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.26545839
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25105618
23E2F7_22180533_ChIP-Seq_HELA_Human2.23018885
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.20816216
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19116688
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.18981863
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.09864914
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05947875
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05473558
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02863377
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99469407
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96814614
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93356323
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89988755
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89988755
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89988755
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87334743
38* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85663378
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83997790
40* VDR_23849224_ChIP-Seq_CD4+_Human1.82606265
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81543591
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81345453
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79525643
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77251339
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73908728
46FOXP3_21729870_ChIP-Seq_TREG_Human1.72672135
47* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.72658148
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.71922065
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70922415
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69354394
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67631406
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66862180
53KDM5A_27292631_Chip-Seq_BREAST_Human1.66531464
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63933454
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.63617915
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63372462
57* XRN2_22483619_ChIP-Seq_HELA_Human1.62089980
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58554991
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58252621
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57560616
61P68_20966046_ChIP-Seq_HELA_Human1.54992846
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53812024
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.50134976
64FOXP1_21924763_ChIP-Seq_HESCs_Human1.49662234
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47972239
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46682438
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.46376414
68* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45525856
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44321235
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44184820
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44172070
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43086696
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.40289364
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39239036
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37706487
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37619552
77VDR_21846776_ChIP-Seq_THP-1_Human1.37311553
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36807270
79* BCL6_27268052_Chip-Seq_Bcells_Human1.35365281
80CIITA_25753668_ChIP-Seq_RAJI_Human1.34968414
81NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33577177
82* ETS1_20019798_ChIP-Seq_JURKAT_Human1.32875633
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32269469
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29202007
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.29102746
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28944225
87* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28906435
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.28793504
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27830852
90DCP1A_22483619_ChIP-Seq_HELA_Human1.25274792
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25236505
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24987839
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24553504
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24458257
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24390708
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23048059
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21505388
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21258958
99PHF8_20622854_ChIP-Seq_HELA_Human1.21164839
100CLOCK_20551151_ChIP-Seq_293T_Human1.20759305
101LXR_22292898_ChIP-Seq_THP-1_Human1.19458085
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19340709
103* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19025672
104POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.18791146
105AR_21909140_ChIP-Seq_LNCAP_Human1.17905339
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17236143
107E2F1_20622854_ChIP-Seq_HELA_Human1.16966443
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16508767
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16277726
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15751826
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14894781
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13843872
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12724669
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.11345382
115MYC_18940864_ChIP-ChIP_HL60_Human1.10789493
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10608429
117* BCOR_27268052_Chip-Seq_Bcells_Human1.08918182
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07471263
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06556418
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.05626260
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05006596
122* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04147440
123* GABP_17652178_ChIP-ChIP_JURKAT_Human1.04080441
124TRIM28_21343339_ChIP-Seq_HEK293_Human1.03969403
125KAP1_27257070_Chip-Seq_ESCs_Mouse1.03843031
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03636525
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03090462
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02771148
129CTCF_26484167_Chip-Seq_Bcells_Mouse1.02652211
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01528963
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01288307
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.01277722
133TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01105716
134CTCF_21964334_Chip-Seq_Bcells_Human1.00256603
135* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99081238
136NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99011587
137* GABP_19822575_ChIP-Seq_HepG2_Human0.98350399
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.98028656
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97570319
140EST1_17652178_ChIP-ChIP_JURKAT_Human0.97306768
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97306008
142TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97060599
143* TP53_20018659_ChIP-ChIP_R1E_Mouse0.95654310
144* CTCF_20526341_ChIP-Seq_ESCs_Human0.94489184
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94159455
146TTF2_22483619_ChIP-Seq_HELA_Human0.93443104
147TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91071677
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90640261
149ATF3_27146783_Chip-Seq_COLON_Human0.90054915
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.88663110
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.86925063
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.86166418
153* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86044180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.27468910
2MP0005360_urolithiasis4.54659795
3MP0003806_abnormal_nucleotide_metabolis4.18419417
4MP0005085_abnormal_gallbladder_physiolo3.92374955
5MP0005365_abnormal_bile_salt3.76621014
6MP0005171_absent_coat_pigmentation3.29125599
7MP0008875_abnormal_xenobiotic_pharmacok2.99127503
8MP0003693_abnormal_embryo_hatching2.73508580
9MP0008058_abnormal_DNA_repair2.72879240
10MP0003136_yellow_coat_color2.68428314
11MP0005394_taste/olfaction_phenotype2.60598270
12MP0005499_abnormal_olfactory_system2.60598270
13MP0004270_analgesia2.54689585
14MP0000372_irregular_coat_pigmentation2.48461716
15MP0009840_abnormal_foam_cell2.43052627
16MP0002234_abnormal_pharynx_morphology2.32698616
17MP0010094_abnormal_chromosome_stability2.31831464
18MP0010030_abnormal_orbit_morphology2.24588295
19MP0004133_heterotaxia2.21011563
20MP0009053_abnormal_anal_canal2.18783070
21MP0002653_abnormal_ependyma_morphology2.09325939
22MP0004957_abnormal_blastocyst_morpholog2.08869709
23MP0001529_abnormal_vocalization2.05946607
24MP0004019_abnormal_vitamin_homeostasis2.04507075
25MP0003252_abnormal_bile_duct1.99109573
26MP0002638_abnormal_pupillary_reflex1.88586361
27MP0002822_catalepsy1.88448812
28MP0003718_maternal_effect1.87321796
29MP0009379_abnormal_foot_pigmentation1.84227901
30MP0010329_abnormal_lipoprotein_level1.81913862
31MP0000566_synostosis1.78320056
32MP0002282_abnormal_trachea_morphology1.75355456
33MP0003705_abnormal_hypodermis_morpholog1.73664549
34MP0000358_abnormal_cell_content/1.71223832
35MP0002160_abnormal_reproductive_system1.69877174
36MP0005332_abnormal_amino_acid1.69683225
37MP0002132_abnormal_respiratory_system1.68364618
38MP0001984_abnormal_olfaction1.67325446
39MP0000537_abnormal_urethra_morphology1.64850408
40MP0006036_abnormal_mitochondrial_physio1.64309169
41MP0008007_abnormal_cellular_replicative1.59771241
42MP0006035_abnormal_mitochondrial_morpho1.58559165
43MP0003119_abnormal_digestive_system1.56387247
44MP0005083_abnormal_biliary_tract1.52239264
45MP0005451_abnormal_body_composition1.47248192
46MP0001666_abnormal_nutrient_absorption1.40927448
47MP0000383_abnormal_hair_follicle1.39440821
48MP0002796_impaired_skin_barrier1.37414330
49MP0005174_abnormal_tail_pigmentation1.34002733
50MP0009278_abnormal_bone_marrow1.27663623
51MP0000538_abnormal_urinary_bladder1.26764517
52MP0006292_abnormal_olfactory_placode1.25709531
53MP0003195_calcinosis1.23935468
54MP0002254_reproductive_system_inflammat1.20247968
55MP0010352_gastrointestinal_tract_polyps1.18366270
56MP0000049_abnormal_middle_ear1.18288762
57MP0003283_abnormal_digestive_organ1.17754496
58MP0010234_abnormal_vibrissa_follicle1.16973308
59MP0009672_abnormal_birth_weight1.15352907
60MP0001346_abnormal_lacrimal_gland1.15016278
61MP0005410_abnormal_fertilization1.12488013
62MP0000462_abnormal_digestive_system1.11713439
63MP0002249_abnormal_larynx_morphology1.11690731
64MP0003329_amyloid_beta_deposits1.09894948
65MP0003115_abnormal_respiratory_system1.08099255
66MP0005248_abnormal_Harderian_gland1.06595952
67MP0001905_abnormal_dopamine_level1.06436378
68MP0000609_abnormal_liver_physiology1.06324920
69MP0005220_abnormal_exocrine_pancreas1.04995242
70MP0000467_abnormal_esophagus_morphology1.04898150
71MP0003111_abnormal_nucleus_morphology1.04457604
72MP0002736_abnormal_nociception_after1.02757893
73MP0005408_hypopigmentation1.02172222
74MP0005395_other_phenotype1.02137360
75MP0008932_abnormal_embryonic_tissue1.01920957
76MP0005501_abnormal_skin_physiology1.00644413
77MP0002111_abnormal_tail_morphology1.00523024
78MP0009697_abnormal_copulation0.99779592
79MP0003186_abnormal_redox_activity0.99159995
80MP0001849_ear_inflammation0.98810530
81MP0005275_abnormal_skin_tensile0.97569173
82MP0003941_abnormal_skin_development0.97079767
83MP0003942_abnormal_urinary_system0.96198986
84MP0002084_abnormal_developmental_patter0.95405507
85MP0002233_abnormal_nose_morphology0.95082156
86MP0001286_abnormal_eye_development0.94718574
87MP0002098_abnormal_vibrissa_morphology0.93959063
88MP0005084_abnormal_gallbladder_morpholo0.92687461
89MP0002697_abnormal_eye_size0.92513166
90MP0002085_abnormal_embryonic_tissue0.92199661
91MP0002138_abnormal_hepatobiliary_system0.90981026
92MP0005623_abnormal_meninges_morphology0.90753447
93MP0000313_abnormal_cell_death0.90724174
94MP0000579_abnormal_nail_morphology0.90548943
95MP0003315_abnormal_perineum_morphology0.90222786
96MP0003011_delayed_dark_adaptation0.89855136
97MP0001293_anophthalmia0.89842242
98MP0002102_abnormal_ear_morphology0.89592666
99MP0000762_abnormal_tongue_morphology0.88318857
100MP0003077_abnormal_cell_cycle0.87983822
101MP0001730_embryonic_growth_arrest0.87721464
102MP0000026_abnormal_inner_ear0.87594261
103MP0006276_abnormal_autonomic_nervous0.85704625
104MP0000490_abnormal_crypts_of0.84884650
105MP0002938_white_spotting0.83588911
106MP0003786_premature_aging0.83281605
107MP0002118_abnormal_lipid_homeostasis0.83193999
108MP0000678_abnormal_parathyroid_gland0.82787387
109MP0003698_abnormal_male_reproductive0.82746472
110MP0002751_abnormal_autonomic_nervous0.82465911
111MP0005319_abnormal_enzyme/_coenzyme0.81861838
112MP0001542_abnormal_bone_strength0.81559660
113MP0002092_abnormal_eye_morphology0.80832151
114MP0000598_abnormal_liver_morphology0.79103526
115MP0008995_early_reproductive_senescence0.79050049
116MP0003890_abnormal_embryonic-extraembry0.77640850
117MP0008789_abnormal_olfactory_epithelium0.77418916
118MP0005367_renal/urinary_system_phenotyp0.76758857
119MP0000516_abnormal_urinary_system0.76758857
120MP0000653_abnormal_sex_gland0.76391102
121MP0009643_abnormal_urine_homeostasis0.75477708
122MP0005380_embryogenesis_phenotype0.75354628
123MP0001672_abnormal_embryogenesis/_devel0.75354628
124MP0002161_abnormal_fertility/fecundity0.74847965
125MP0001764_abnormal_homeostasis0.74340368
126MP0001929_abnormal_gametogenesis0.74251039
127MP0004147_increased_porphyrin_level0.73559210
128MP0002086_abnormal_extraembryonic_tissu0.73331215
129MP0000647_abnormal_sebaceous_gland0.73283526
130MP0001145_abnormal_male_reproductive0.73205911
131MP0000350_abnormal_cell_proliferation0.73203211
132MP0000534_abnormal_ureter_morphology0.72800746
133MP0005646_abnormal_pituitary_gland0.72303055
134MP0002019_abnormal_tumor_incidence0.72296250
135MP0008438_abnormal_cutaneous_collagen0.72273454
136MP0003861_abnormal_nervous_system0.71874219
137MP0004197_abnormal_fetal_growth/weight/0.71531098
138MP0003936_abnormal_reproductive_system0.71522880
139MP0009703_decreased_birth_body0.71227961
140MP0005389_reproductive_system_phenotype0.70975402
141MP0002210_abnormal_sex_determination0.70777971
142MP0001697_abnormal_embryo_size0.70282533
143MP0002080_prenatal_lethality0.67795433
144MP0005384_cellular_phenotype0.67478438
145MP0000604_amyloidosis0.66624159
146MP0001324_abnormal_eye_pigmentation0.66294719
147MP0001727_abnormal_embryo_implantation0.65243122
148MP0003937_abnormal_limbs/digits/tail_de0.62575907
149MP0005391_vision/eye_phenotype0.59105015

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)7.97111948
2Neoplasm of the adrenal cortex (HP:0100641)6.85002882
3Abnormal ciliary motility (HP:0012262)6.57856832
4Long foot (HP:0001833)6.17280279
5Abnormal pancreas size (HP:0012094)6.11440987
6Neonatal hypoglycemia (HP:0001998)5.74379020
7Rhinitis (HP:0012384)5.67669345
8Diastasis recti (HP:0001540)5.58593048
9High anterior hairline (HP:0009890)4.87286374
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.31491943
11Hypobetalipoproteinemia (HP:0003563)4.25649912
12Enlarged kidneys (HP:0000105)3.99027598
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75465706
14Intrahepatic cholestasis (HP:0001406)3.57778262
15Overgrowth (HP:0001548)3.55196807
16Bronchiectasis (HP:0002110)3.54607981
17Deep venous thrombosis (HP:0002625)3.48974030
18Neoplasm of the adrenal gland (HP:0100631)3.47955006
19Partial agenesis of the corpus callosum (HP:0001338)3.32889575
20Mitochondrial inheritance (HP:0001427)3.32666846
21Abnormal mitochondria in muscle tissue (HP:0008316)3.32382835
22Acute necrotizing encephalopathy (HP:0006965)3.30056997
23Pancreatic fibrosis (HP:0100732)3.29685429
24Germ cell neoplasia (HP:0100728)3.29233720
25Testicular atrophy (HP:0000029)3.28702432
26Acute encephalopathy (HP:0006846)3.26481275
27Abnormality of pyrimidine metabolism (HP:0004353)3.24193950
28True hermaphroditism (HP:0010459)3.20393838
29Occipital encephalocele (HP:0002085)3.19977291
30Nasal polyposis (HP:0100582)3.17532236
31Hepatocellular necrosis (HP:0001404)3.17262102
32Male infertility (HP:0003251)3.12421740
33Hyperglycinemia (HP:0002154)3.11290066
34Breast hypoplasia (HP:0003187)3.10471379
35Xanthomatosis (HP:0000991)3.06757851
36Advanced eruption of teeth (HP:0006288)3.01582653
37Abnormal glucose tolerance (HP:0001952)3.00930352
38Carpal bone hypoplasia (HP:0001498)2.96644009
39Increased CSF lactate (HP:0002490)2.89967808
40Infertility (HP:0000789)2.89273053
41Hand muscle atrophy (HP:0009130)2.82124661
42Hypolipoproteinemia (HP:0010981)2.81624676
43Renal Fanconi syndrome (HP:0001994)2.81042621
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77924043
45Increased hepatocellular lipid droplets (HP:0006565)2.73745963
46Type I transferrin isoform profile (HP:0003642)2.66939150
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65056694
48Hepatic necrosis (HP:0002605)2.63617170
49Increased intramyocellular lipid droplets (HP:0012240)2.61563583
50Genu varum (HP:0002970)2.60822853
51Pancreatic cysts (HP:0001737)2.59958287
52Postaxial foot polydactyly (HP:0001830)2.57139825
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53833151
54Prolonged partial thromboplastin time (HP:0003645)2.53223726
55Exercise intolerance (HP:0003546)2.52538108
56Abnormality of midbrain morphology (HP:0002418)2.51513786
57Molar tooth sign on MRI (HP:0002419)2.51513786
58Degeneration of anterior horn cells (HP:0002398)2.51130358
59Abnormality of the anterior horn cell (HP:0006802)2.51130358
60Medial flaring of the eyebrow (HP:0010747)2.48475080
61Sclerocornea (HP:0000647)2.46932784
6211 pairs of ribs (HP:0000878)2.46105144
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44626109
64Nephronophthisis (HP:0000090)2.44622489
65Distal lower limb muscle weakness (HP:0009053)2.44081777
66Atelectasis (HP:0100750)2.43482440
67Spinal muscular atrophy (HP:0007269)2.43151795
68Abnormality of serine family amino acid metabolism (HP:0010894)2.40937628
69Abnormality of glycine metabolism (HP:0010895)2.40937628
70Hyperlipoproteinemia (HP:0010980)2.39803421
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.39747548
72Cystic liver disease (HP:0006706)2.39403319
73Lipid accumulation in hepatocytes (HP:0006561)2.38872199
74Abnormality of the nasal mucosa (HP:0000433)2.38054797
75Malnutrition (HP:0004395)2.35003096
76Gout (HP:0001997)2.32998913
77Lactic acidosis (HP:0003128)2.32613526
78Progressive macrocephaly (HP:0004481)2.30764598
79Neoplasm of the liver (HP:0002896)2.28833635
80Hyperglycinuria (HP:0003108)2.27913218
81Microvesicular hepatic steatosis (HP:0001414)2.27251121
82Abnormal gallbladder physiology (HP:0012438)2.26730316
83Cholecystitis (HP:0001082)2.26730316
84Increased serum lactate (HP:0002151)2.25692978
85Congenital primary aphakia (HP:0007707)2.25067623
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24980926
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.24795907
88Preaxial hand polydactyly (HP:0001177)2.24596465
89Abnormal number of erythroid precursors (HP:0012131)2.21817650
90Chronic sinusitis (HP:0011109)2.20657804
91Cerebral edema (HP:0002181)2.19471782
92Abnormal protein glycosylation (HP:0012346)2.18937637
93Abnormal glycosylation (HP:0012345)2.18937637
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18937637
95Abnormal protein N-linked glycosylation (HP:0012347)2.18937637
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18276172
97Absent epiphyses (HP:0010577)2.18276172
98Increased muscle lipid content (HP:0009058)2.17580205
99Congenital hepatic fibrosis (HP:0002612)2.16445385
100Distal upper limb amyotrophy (HP:0007149)2.15877255
101Upper limb amyotrophy (HP:0009129)2.15877255
102Gait imbalance (HP:0002141)2.14710979
103Abnormality of glycolysis (HP:0004366)2.13785826
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13007022
105Abnormality of the distal phalanges of the toes (HP:0010182)2.11641069
106Nephroblastoma (Wilms tumor) (HP:0002667)2.10751570
107Tubulointerstitial nephritis (HP:0001970)2.10275569
108Anencephaly (HP:0002323)2.08349608
109Abnormality of the lower motor neuron (HP:0002366)2.04983733
110Missing ribs (HP:0000921)2.04676408
111Embryonal renal neoplasm (HP:0011794)2.03306211
112Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02998861
113Nephrogenic diabetes insipidus (HP:0009806)2.02818757
114Abnormality of sulfur amino acid metabolism (HP:0004339)2.01617520
115Hypoalphalipoproteinemia (HP:0003233)2.00901619
116Aplasia of the musculature (HP:0100854)1.99264770
117Abnormality of cells of the erythroid lineage (HP:0012130)1.98697423
118Optic nerve coloboma (HP:0000588)1.97920095
119Hypoplastic toenails (HP:0001800)1.97341375
120Asymmetric growth (HP:0100555)1.97077152
121Spastic diplegia (HP:0001264)1.95369228
122Ketosis (HP:0001946)1.95072706
123Hyperammonemia (HP:0001987)1.94264954
124Dyschromatopsia (HP:0007641)1.93813280
125Abnormality of the renal medulla (HP:0100957)1.93502823
126Increased serum pyruvate (HP:0003542)1.93224413
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93025785
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93025785
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91656616
130Poor coordination (HP:0002370)1.91443244
131Fat malabsorption (HP:0002630)1.91081628
132Abnormality of nucleobase metabolism (HP:0010932)1.89864424
133Epidermoid cyst (HP:0200040)1.89538909
134Chronic bronchitis (HP:0004469)1.89191741
135Abnormal respiratory epithelium morphology (HP:0012253)1.87494610
136Abnormal respiratory motile cilium morphology (HP:0005938)1.87494610
137Flat acetabular roof (HP:0003180)1.87493926
138Muscle fiber atrophy (HP:0100295)1.87056972
139Abnormality of serum amino acid levels (HP:0003112)1.85241831
140Abnormal respiratory motile cilium physiology (HP:0012261)1.84314264
141Absent/shortened dynein arms (HP:0200106)1.83792955
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.83792955
143Vascular calcification (HP:0004934)1.82797720
144Hypoplastic pelvis (HP:0008839)1.81825776
145Cerebral hypomyelination (HP:0006808)1.80873549
146Male pseudohermaphroditism (HP:0000037)1.79962167
147Abnormality of the labia minora (HP:0012880)1.78341254
148Short nail (HP:0001799)1.75837032
149Respiratory failure (HP:0002878)1.75388546
150Birth length less than 3rd percentile (HP:0003561)1.75217554
151Abnormal biliary tract physiology (HP:0012439)1.74266449
152Bile duct proliferation (HP:0001408)1.74266449
153Broad distal phalanx of finger (HP:0009836)1.73041821
154Abdominal situs inversus (HP:0003363)1.72131114
155Abnormality of abdominal situs (HP:0011620)1.72131114
156Down-sloping shoulders (HP:0200021)1.71264308
157Conjugated hyperbilirubinemia (HP:0002908)1.69409373
158Cardiovascular calcification (HP:0011915)1.69344195
159Right ventricular cardiomyopathy (HP:0011663)1.68838808
160Type 2 muscle fiber atrophy (HP:0003554)1.68684997
161Abnormality of methionine metabolism (HP:0010901)1.68502986
162Emotional lability (HP:0000712)1.68314684
163Reticulocytopenia (HP:0001896)1.67391028
164Postaxial hand polydactyly (HP:0001162)1.67155804
165Cortical dysplasia (HP:0002539)1.66789728
166Respiratory difficulties (HP:0002880)1.66388192
167Aplasia/Hypoplasia of the spleen (HP:0010451)1.66087455
168Reduced antithrombin III activity (HP:0001976)1.65997363
169Lethargy (HP:0001254)1.65803098
170Ependymoma (HP:0002888)1.65730198
171Atrophy/Degeneration involving motor neurons (HP:0007373)1.64986454
172Ragged-red muscle fibers (HP:0003200)1.64815021
173Abnormality of the septum pellucidum (HP:0007375)1.64440724
174Recurrent sinusitis (HP:0011108)1.64055251
175Prolonged neonatal jaundice (HP:0006579)1.63728607
176Delayed CNS myelination (HP:0002188)1.63678532
177Shawl scrotum (HP:0000049)1.62546481
178Esophageal varix (HP:0002040)1.62329927
179Complement deficiency (HP:0004431)1.62228781
180Abnormality of dentin (HP:0010299)1.62121327
181Rough bone trabeculation (HP:0100670)1.61857463
182Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61385598
183Spinal cord compression (HP:0002176)1.61255876
184Brushfield spots (HP:0001088)1.60406369
185Irritability (HP:0000737)1.58577429
186Impulsivity (HP:0100710)1.58370490
187Aplasia/Hypoplasia of the sternum (HP:0006714)1.55352984
188Supernumerary spleens (HP:0009799)1.53739352
189Embryonal neoplasm (HP:0002898)1.53550935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.35704948
2VRK25.23501708
3STK165.14790396
4PRKG23.19355360
5VRK12.92714006
6TRIM282.82652479
7MKNK22.46571963
8WEE12.34171189
9MAP4K22.19967006
10MARK12.13891405
11EPHB22.11441424
12TESK12.11072338
13NEK12.06116262
14WNK32.03672013
15LATS22.03585290
16SMG11.99981016
17DYRK21.87936383
18STK38L1.83096589
19BUB11.79209596
20NME11.68585003
21PBK1.66727546
22RPS6KB21.65516282
23BCKDK1.62717103
24PRKCI1.61777870
25RIPK11.61130416
26TLK11.59526617
27AKT31.59073541
28MKNK11.58329366
29PDK31.48469083
30PDK41.48469083
31PAK41.46622170
32PIM21.37923555
33NEK21.36845549
34MST41.36757677
35MAP2K21.35649088
36IRAK31.33109218
37DYRK1B1.32526213
38PNCK1.28126395
39FER1.26995110
40KDR1.23566681
41CCNB11.23451004
42BRSK21.23006337
43DYRK31.20491380
44MAPK151.19756123
45TESK21.18053526
46MAPKAPK31.17436351
47AURKA1.16849243
48SIK11.15987075
49CAMK2B1.12681779
50CDK81.12637584
51ZAK1.12115562
52PAK31.09480824
53CAMK2G1.07884357
54BRAF1.04909222
55LRRK21.02324252
56BCR1.02246262
57MAP3K121.02082740
58ATR1.01418750
59MAP3K31.01112481
60SIK20.99201658
61PLK10.98394031
62BRSK10.97801118
63DAPK30.97571725
64TGFBR10.97487874
65ERBB40.97167971
66DDR20.94472070
67NUAK10.92238448
68MAP2K70.91982696
69ACVR1B0.91698390
70TTK0.91460879
71PDK20.89902393
72ICK0.86699936
73CDK70.86470531
74LATS10.86066323
75MAP2K10.84445408
76TAF10.83100800
77PLK30.81726747
78RPS6KA50.81400279
79LMTK20.77411220
80LIMK10.75850845
81SRPK10.74719240
82DAPK10.73322798
83PTK20.69189049
84CDK190.69120028
85PRKD30.68990258
86ALK0.68381275
87CDC70.68055244
88CDK120.67030778
89FGFR40.66222478
90MAP3K110.66150187
91CSNK1E0.64966991
92EIF2AK10.62617043
93IRAK20.61867356
94PASK0.61780257
95MAPKAPK50.60880999
96CHEK20.58949560
97MTOR0.58682671
98BMX0.58190299
99CSNK1G30.58050081
100EEF2K0.57399079
101ERBB20.56938977
102CDK60.56927725
103BMPR1B0.56852768
104CAMK2D0.56358377
105AURKB0.54793737
106CSNK1G10.52887434
107ILK0.52481224
108DYRK1A0.48953621
109ABL20.46197675
110TSSK60.45706529
111CDK140.45638569
112NME20.44737478
113MINK10.44039878
114CDK11A0.43509342
115CDK180.42441570
116DAPK20.42414702
117NTRK20.41985623
118AKT20.41745903
119CDK90.41642516
120MUSK0.41036907
121PRKCZ0.40995727
122TBK10.39922071
123ARAF0.39560383
124CDK150.39553195
125CSNK1A1L0.39504888
126MAPK110.39353189
127MET0.38681707
128KSR10.38348705
129ERBB30.38207259
130PLK40.36617244
131ERN10.36464336
132MAP3K90.36035082
133MAP3K20.35653146
134PAK20.35251094
135GRK50.34927431
136CSNK2A10.33416150
137PAK10.33147517
138CSNK1G20.32889583
139ATM0.32079524
140CHEK10.32003077
141TAOK20.31703649
142SCYL20.31051001
143MAP3K80.30876321
144TRIB30.28509237
145CDK20.28480007
146PKN20.24777564

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.40763037
2Base excision repair_Homo sapiens_hsa034103.28300979
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84469212
4Oxidative phosphorylation_Homo sapiens_hsa001902.63252566
5Parkinsons disease_Homo sapiens_hsa050122.49171334
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48453769
7Selenocompound metabolism_Homo sapiens_hsa004502.43996403
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39741745
9Homologous recombination_Homo sapiens_hsa034402.39288766
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27078942
11Arginine biosynthesis_Homo sapiens_hsa002202.26255492
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20002339
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.18779290
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.14016470
15Tryptophan metabolism_Homo sapiens_hsa003802.13591983
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08151673
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05356561
18Chemical carcinogenesis_Homo sapiens_hsa052042.00102011
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.98783683
20Nitrogen metabolism_Homo sapiens_hsa009101.97977510
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97099762
22Complement and coagulation cascades_Homo sapiens_hsa046101.92120016
23Proteasome_Homo sapiens_hsa030501.90814749
24Fanconi anemia pathway_Homo sapiens_hsa034601.83148864
25Butanoate metabolism_Homo sapiens_hsa006501.77996700
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72902854
27One carbon pool by folate_Homo sapiens_hsa006701.70951296
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69934803
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69142228
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63936337
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.62056811
32Histidine metabolism_Homo sapiens_hsa003401.61075937
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55699027
34Glutathione metabolism_Homo sapiens_hsa004801.55295152
35Retinol metabolism_Homo sapiens_hsa008301.53031794
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.51046485
37Peroxisome_Homo sapiens_hsa041461.50588220
38Alzheimers disease_Homo sapiens_hsa050101.47104797
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.46343087
40Biosynthesis of amino acids_Homo sapiens_hsa012301.44516772
41Fatty acid degradation_Homo sapiens_hsa000711.44381794
42Phenylalanine metabolism_Homo sapiens_hsa003601.43989818
43Folate biosynthesis_Homo sapiens_hsa007901.31998743
44Lysine degradation_Homo sapiens_hsa003101.25360574
45Fat digestion and absorption_Homo sapiens_hsa049751.25165199
46Pyruvate metabolism_Homo sapiens_hsa006201.24092098
47Vitamin digestion and absorption_Homo sapiens_hsa049771.23143388
48Tyrosine metabolism_Homo sapiens_hsa003501.19335038
49Non-homologous end-joining_Homo sapiens_hsa034501.18027659
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17247578
51PPAR signaling pathway_Homo sapiens_hsa033201.16844744
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15282514
53N-Glycan biosynthesis_Homo sapiens_hsa005101.15112081
54Bile secretion_Homo sapiens_hsa049761.13497840
55Caffeine metabolism_Homo sapiens_hsa002321.11683753
56Basal transcription factors_Homo sapiens_hsa030221.10478414
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08756016
58Arginine and proline metabolism_Homo sapiens_hsa003301.08188355
59Steroid biosynthesis_Homo sapiens_hsa001001.08097093
60Vitamin B6 metabolism_Homo sapiens_hsa007501.06202281
61Mismatch repair_Homo sapiens_hsa034301.03971206
62Ribosome_Homo sapiens_hsa030101.03676086
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02552159
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01488808
65beta-Alanine metabolism_Homo sapiens_hsa004101.01034590
66Carbon metabolism_Homo sapiens_hsa012000.97901827
67RNA transport_Homo sapiens_hsa030130.97621398
68Pyrimidine metabolism_Homo sapiens_hsa002400.96348745
69RNA polymerase_Homo sapiens_hsa030200.94126839
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91217507
71African trypanosomiasis_Homo sapiens_hsa051430.90330995
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88414853
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87981973
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86672892
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83547301
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80841919
77Fatty acid metabolism_Homo sapiens_hsa012120.80325210
78p53 signaling pathway_Homo sapiens_hsa041150.79740139
79Bladder cancer_Homo sapiens_hsa052190.77077163
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75478770
81RNA degradation_Homo sapiens_hsa030180.73723947
82Basal cell carcinoma_Homo sapiens_hsa052170.73537464
83DNA replication_Homo sapiens_hsa030300.72991918
84Propanoate metabolism_Homo sapiens_hsa006400.72873584
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.72258715
86Hedgehog signaling pathway_Homo sapiens_hsa043400.69938014
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67670561
88Sulfur relay system_Homo sapiens_hsa041220.66984546
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65981010
90Hippo signaling pathway_Homo sapiens_hsa043900.65181322
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64426406
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64245486
93Fructose and mannose metabolism_Homo sapiens_hsa000510.64096112
94Protein export_Homo sapiens_hsa030600.63454447
95Alcoholism_Homo sapiens_hsa050340.59599348
96Starch and sucrose metabolism_Homo sapiens_hsa005000.58348075
97Metabolic pathways_Homo sapiens_hsa011000.57473429
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57260012
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56456229
100Fatty acid elongation_Homo sapiens_hsa000620.53538170
101Spliceosome_Homo sapiens_hsa030400.50289760
102Nucleotide excision repair_Homo sapiens_hsa034200.48881026
103Pentose phosphate pathway_Homo sapiens_hsa000300.48060851
104Cell cycle_Homo sapiens_hsa041100.47909507
105Cardiac muscle contraction_Homo sapiens_hsa042600.46054701
106Huntingtons disease_Homo sapiens_hsa050160.45901073
107mRNA surveillance pathway_Homo sapiens_hsa030150.44885076
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43635042
109Phototransduction_Homo sapiens_hsa047440.41868678
110Prion diseases_Homo sapiens_hsa050200.41786986
111Glycerolipid metabolism_Homo sapiens_hsa005610.41230120
112Sulfur metabolism_Homo sapiens_hsa009200.40934203
113Glucagon signaling pathway_Homo sapiens_hsa049220.40802956
114Oocyte meiosis_Homo sapiens_hsa041140.40670182
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40591110
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36390238
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35437833
118Galactose metabolism_Homo sapiens_hsa000520.34451356
119Amoebiasis_Homo sapiens_hsa051460.33623804
120Vibrio cholerae infection_Homo sapiens_hsa051100.33075392
121Systemic lupus erythematosus_Homo sapiens_hsa053220.32967738
122Thyroid hormone synthesis_Homo sapiens_hsa049180.32413591
123Staphylococcus aureus infection_Homo sapiens_hsa051500.31482156
124ABC transporters_Homo sapiens_hsa020100.30855465
125Linoleic acid metabolism_Homo sapiens_hsa005910.30355867
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30268425
127Arachidonic acid metabolism_Homo sapiens_hsa005900.29991321
128Melanogenesis_Homo sapiens_hsa049160.26380713
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26363829
130Regulation of autophagy_Homo sapiens_hsa041400.24608510
131Epstein-Barr virus infection_Homo sapiens_hsa051690.23167261
132Purine metabolism_Homo sapiens_hsa002300.21289213
133Notch signaling pathway_Homo sapiens_hsa043300.21281523
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21147957
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19682767
136Sphingolipid metabolism_Homo sapiens_hsa006000.17901301
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17649910

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