FCAMR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.42405630
2drug transmembrane transport (GO:0006855)8.09048049
3aminoglycoside antibiotic metabolic process (GO:0030647)6.87586767
4exogenous drug catabolic process (GO:0042738)6.72629987
5drug transport (GO:0015893)6.67513747
6drug catabolic process (GO:0042737)6.60423898
7phosphate ion transport (GO:0006817)5.99860639
8regulation of T-helper 1 cell differentiation (GO:0045625)5.77677890
9organic cation transport (GO:0015695)5.73814846
10regulation of vitamin D biosynthetic process (GO:0060556)5.60364579
11quaternary ammonium group transport (GO:0015697)5.57150851
12regulation of cytokine secretion involved in immune response (GO:0002739)5.48144299
13regulation of chronic inflammatory response (GO:0002676)5.40225959
14lysine metabolic process (GO:0006553)5.13648022
15lysine catabolic process (GO:0006554)5.13648022
16phosphate ion transmembrane transport (GO:0035435)5.12842522
17glyoxylate metabolic process (GO:0046487)4.98249062
18cysteine metabolic process (GO:0006534)4.86373474
19regulation of vitamin metabolic process (GO:0030656)4.78565667
20response to phenylpropanoid (GO:0080184)4.64925365
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64204135
22valine metabolic process (GO:0006573)4.53629520
23vitamin D metabolic process (GO:0042359)4.47731590
24regulation of interferon-alpha production (GO:0032647)4.47573786
25short-chain fatty acid metabolic process (GO:0046459)4.41863531
26carnitine transport (GO:0015879)4.39448434
27amino-acid betaine transport (GO:0015838)4.39448434
28cellular response to type I interferon (GO:0071357)4.39164312
29type I interferon signaling pathway (GO:0060337)4.39164312
30branching involved in labyrinthine layer morphogenesis (GO:0060670)4.36202134
31response to type I interferon (GO:0034340)4.33520592
32negative regulation of interleukin-12 production (GO:0032695)4.33458752
33phosphate ion homeostasis (GO:0055062)4.12942774
34trivalent inorganic anion homeostasis (GO:0072506)4.12942774
35antigen processing and presentation of endogenous antigen (GO:0019883)4.12877168
36homocysteine metabolic process (GO:0050667)4.06025406
37tricarboxylic acid metabolic process (GO:0072350)4.03893902
38excretion (GO:0007588)3.99286534
39regulation of fever generation (GO:0031620)3.95658478
40response to mercury ion (GO:0046689)3.94937669
41desmosome organization (GO:0002934)3.94285301
42positive regulation of heat generation (GO:0031652)3.92803692
43regulation of immunoglobulin secretion (GO:0051023)3.87744044
44beta-amyloid metabolic process (GO:0050435)3.86201641
45branched-chain amino acid metabolic process (GO:0009081)3.83619845
46toxin transport (GO:1901998)3.81582002
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79147981
48L-phenylalanine metabolic process (GO:0006558)3.79147981
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.78770037
50sodium-independent organic anion transport (GO:0043252)3.72833156
51cellular modified amino acid catabolic process (GO:0042219)3.72187091
52amino-acid betaine metabolic process (GO:0006577)3.71390000
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.68297892
54L-phenylalanine catabolic process (GO:0006559)3.68297892
55aromatic amino acid family catabolic process (GO:0009074)3.64505356
56myeloid dendritic cell differentiation (GO:0043011)3.63890597
57sphingoid metabolic process (GO:0046519)3.62822787
58positive regulation of chemokine biosynthetic process (GO:0045080)3.62161436
59negative regulation of cytokine production involved in immune response (GO:0002719)3.60266513
60indole-containing compound catabolic process (GO:0042436)3.59318851
61indolalkylamine catabolic process (GO:0046218)3.59318851
62tryptophan catabolic process (GO:0006569)3.59318851
63serine family amino acid catabolic process (GO:0009071)3.57944310
64tryptophan metabolic process (GO:0006568)3.56966759
65germinal center formation (GO:0002467)3.55159952
66proline metabolic process (GO:0006560)3.54983185
67fatty acid beta-oxidation (GO:0006635)3.54354131
68renal absorption (GO:0070293)3.53649364
69peptide catabolic process (GO:0043171)3.52680033
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.52566502
71B cell receptor signaling pathway (GO:0050853)3.49888408
72acetyl-CoA metabolic process (GO:0006084)3.48963146
73T-helper 1 type immune response (GO:0042088)3.48607770
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.47131382
75regulation of chemokine biosynthetic process (GO:0045073)3.45077522
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.42094593
77regulation of cholesterol homeostasis (GO:2000188)3.40480144
78NIK/NF-kappaB signaling (GO:0038061)3.37691043
79virion attachment to host cell (GO:0019062)3.36828782
80adhesion of symbiont to host cell (GO:0044650)3.36828782
81sulfur amino acid catabolic process (GO:0000098)3.36789763
82defense response to protozoan (GO:0042832)3.36569255
83acute-phase response (GO:0006953)3.35798242
84regulation of podosome assembly (GO:0071801)3.35273239
85response to peptidoglycan (GO:0032494)3.34915448
86carnitine metabolic process (GO:0009437)3.34886557
87negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.34851366
88regulation of nitric oxide biosynthetic process (GO:0045428)3.33783192
89regulation of membrane protein ectodomain proteolysis (GO:0051043)3.33352557
90positive regulation of nitric oxide biosynthetic process (GO:0045429)3.29970419
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29878534
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29878534
93positive regulation of interferon-alpha production (GO:0032727)3.29651329
94negative regulation of amino acid transport (GO:0051956)3.28696625
95fatty acid oxidation (GO:0019395)3.28315813
96response to protozoan (GO:0001562)3.28060374
97regulation of mononuclear cell migration (GO:0071675)3.25674885
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25220187
99regulation of heterotypic cell-cell adhesion (GO:0034114)3.24942153
100aspartate family amino acid catabolic process (GO:0009068)3.23284161
101epoxygenase P450 pathway (GO:0019373)3.22423606
102positive regulation of antigen processing and presentation (GO:0002579)3.20957292
103macrophage activation involved in immune response (GO:0002281)3.20507287
104complement activation, alternative pathway (GO:0006957)3.20358110
105lipid oxidation (GO:0034440)3.19703760
106interferon-gamma-mediated signaling pathway (GO:0060333)3.19398586
107positive regulation of acute inflammatory response (GO:0002675)3.17595665
108fat-soluble vitamin biosynthetic process (GO:0042362)3.16116329
109negative regulation of growth of symbiont in host (GO:0044130)3.14729555
110negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.14729555
111modulation of growth of symbiont involved in interaction with host (GO:0044144)3.14729555
112regulation of growth of symbiont in host (GO:0044126)3.14729555
113modified amino acid transport (GO:0072337)3.14220236
114regulation of T-helper cell differentiation (GO:0045622)3.14035454
115adhesion of symbiont to host (GO:0044406)3.12301072
116carnitine transmembrane transport (GO:1902603)3.11954335
117regulation of antigen processing and presentation (GO:0002577)3.10279478
118positive regulation of type 2 immune response (GO:0002830)3.09698748
119ethanol oxidation (GO:0006069)3.08151232
120diol metabolic process (GO:0034311)3.06623323
121immunoglobulin mediated immune response (GO:0016064)3.05996952
122regulation of interleukin-12 production (GO:0032655)3.05167649
123myeloid dendritic cell activation (GO:0001773)3.03603675
124positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02652409
1252-oxoglutarate metabolic process (GO:0006103)3.00667158
126fatty acid catabolic process (GO:0009062)2.98671495
127glycoside metabolic process (GO:0016137)2.98402401
128ethanol metabolic process (GO:0006067)2.98254103
129serine family amino acid metabolic process (GO:0009069)2.97775575
130regulation of interleukin-8 biosynthetic process (GO:0045414)2.97276384
131negative regulation of viral genome replication (GO:0045071)2.96667073
132regulation of heat generation (GO:0031650)2.95721855
133nonribosomal peptide biosynthetic process (GO:0019184)2.94845068
134regulation of inflammatory response to antigenic stimulus (GO:0002861)2.94494200
135fructose metabolic process (GO:0006000)2.94391116
136negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93255575
137positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93204735
138fibrinolysis (GO:0042730)2.92991073
139regulation of interferon-gamma biosynthetic process (GO:0045072)2.92971506
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.92612172
141dendritic cell differentiation (GO:0097028)2.91885229
142cellular response to lipopolysaccharide (GO:0071222)2.91541421
143hydrogen peroxide biosynthetic process (GO:0050665)2.90551838
144branched-chain amino acid catabolic process (GO:0009083)2.89899351
145chronic inflammatory response (GO:0002544)2.89250608
146negative regulation of production of molecular mediator of immune response (GO:0002701)2.88841485
147drug metabolic process (GO:0017144)2.88012562
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87792753
149sphingosine metabolic process (GO:0006670)2.85977857
150positive regulation of T-helper cell differentiation (GO:0045624)2.85778296
151positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85288268
152positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85068555
153metanephric tubule development (GO:0072170)2.84614624
154metanephric nephron tubule development (GO:0072234)2.84614624
155activation of MAPKKK activity (GO:0000185)2.84083589
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84011748
157detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.83489225
158bile acid biosynthetic process (GO:0006699)2.82442078
159biotin metabolic process (GO:0006768)2.80985334
160cellular response to molecule of bacterial origin (GO:0071219)2.80121199
161positive regulation of natural killer cell differentiation (GO:0032825)2.79396854
162positive regulation of gamma-delta T cell activation (GO:0046645)2.78653293
163response to growth hormone (GO:0060416)2.78611694
164vitamin transport (GO:0051180)2.78143026
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77124644
166surfactant homeostasis (GO:0043129)2.76740845
167regulation of bile acid biosynthetic process (GO:0070857)2.76313369
168regulation of NF-kappaB import into nucleus (GO:0042345)2.75930448
169transcytosis (GO:0045056)2.74663663
170monocarboxylic acid catabolic process (GO:0072329)2.73268833
171glycosphingolipid catabolic process (GO:0046479)2.73174783
172positive regulation of interleukin-12 production (GO:0032735)2.72415577
173positive regulation of defense response to virus by host (GO:0002230)2.71223893
174cellular amino acid catabolic process (GO:0009063)2.70573161
175regulation of T-helper 1 type immune response (GO:0002825)2.70130819
176regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69835879
177regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69716301
178pyrimidine ribonucleoside catabolic process (GO:0046133)2.68397522
179transepithelial transport (GO:0070633)2.67362172
180hormone catabolic process (GO:0042447)2.67336637
181positive regulation of lipid storage (GO:0010884)2.67133379
182regulation of RIG-I signaling pathway (GO:0039535)2.66529374
183positive regulation of catenin import into nucleus (GO:0035413)2.66400464
184benzene-containing compound metabolic process (GO:0042537)2.66255274
185regulation of protein activation cascade (GO:2000257)2.65964982
186interferon-gamma secretion (GO:0072643)2.65922046
187sulfate transmembrane transport (GO:1902358)2.65092350
188sulfur compound transport (GO:0072348)2.64693329
189aromatic amino acid family metabolic process (GO:0009072)2.63609204
190cellular ketone body metabolic process (GO:0046950)2.63312489
191glutathione biosynthetic process (GO:0006750)2.62969772
192antibacterial humoral response (GO:0019731)2.61842576
193kynurenine metabolic process (GO:0070189)2.60078497
194pantothenate metabolic process (GO:0015939)2.59746470
195metanephric nephron epithelium development (GO:0072243)2.59584434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.69802516
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.53203886
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.26373698
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.00663946
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.66243219
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.51284992
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01157955
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.94021570
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.85500159
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.65834924
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54275065
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.46512592
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43405276
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29874907
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28466760
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.24992428
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.18968569
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.15827517
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.09024358
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08947905
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92313010
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88591313
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84712832
24MYC_22102868_ChIP-Seq_BL_Human1.83857836
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79325420
26GATA1_22025678_ChIP-Seq_K562_Human1.75674616
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75650607
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72401387
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.72159672
30GATA4_25053715_ChIP-Seq_YYC3_Human1.70417096
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67387779
32RUNX_20019798_ChIP-Seq_JUKART_Human1.66684428
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65876030
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63411709
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61718382
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60074663
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59534208
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.59217709
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58400885
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58372318
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56948823
42* GATA6_25053715_ChIP-Seq_YYC3_Human1.54157679
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52884608
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52757722
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.50529046
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.49788980
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48682414
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42440704
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41211792
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37995656
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37550377
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36609708
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36412459
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35545985
55CLOCK_20551151_ChIP-Seq_293T_Human1.33763987
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33222803
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29225733
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28570749
59LXR_22292898_ChIP-Seq_THP-1_Human1.27942748
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27209171
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26325904
62RACK7_27058665_Chip-Seq_MCF-7_Human1.24575703
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24255008
64* MYB_26560356_Chip-Seq_TH1_Human1.24197141
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24047707
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23652940
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22408872
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.21122405
69VDR_21846776_ChIP-Seq_THP-1_Human1.20500752
70SPI1_23127762_ChIP-Seq_K562_Human1.20105318
71SOX2_20726797_ChIP-Seq_SW620_Human1.19824437
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19445593
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17696016
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16625515
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15639328
76TCF7_22412390_ChIP-Seq_EML_Mouse1.15585010
77UTX_26944678_Chip-Seq_JUKART_Human1.15208532
78MAF_26560356_Chip-Seq_TH1_Human1.14750861
79RXR_22108803_ChIP-Seq_LS180_Human1.14578405
80AHR_22903824_ChIP-Seq_MCF-7_Human1.13707112
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13008025
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11691823
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11091565
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.10443682
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.10443682
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.10125982
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10059321
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.09735808
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09678007
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08937675
91P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07973081
92SPI1_23547873_ChIP-Seq_NB4_Human1.07597172
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07371220
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.07327552
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07189675
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07072295
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05289492
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05243899
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05021676
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.04443978
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03618463
102* TP63_23658742_ChIP-Seq_EP156T_Human1.03515275
103GATA3_27048872_Chip-Seq_THYMUS_Human1.03499137
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03378716
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03168830
106GATA2_19941826_ChIP-Seq_K562_Human1.03097288
107STAT1_20625510_ChIP-Seq_HELA_Human1.02890155
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02629913
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02629913
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02629913
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02169841
112MYB_26560356_Chip-Seq_TH2_Human1.01976108
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01475316
114CDX2_22108803_ChIP-Seq_LS180_Human0.98873522
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97842696
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.97547107
117* PU_27001747_Chip-Seq_BMDM_Mouse0.96763806
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96445217
119VDR_24787735_ChIP-Seq_THP-1_Human0.96070965
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95927315
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93527974
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.93283633
123KDM2B_26808549_Chip-Seq_DND41_Human0.92592971
124GATA1_19941826_ChIP-Seq_K562_Human0.92268440
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.91663836
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90744135
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89906309
128EGR1_19032775_ChIP-ChIP_M12_Human0.89464040
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.88947050
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87880187
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87790904
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87658998
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87183215
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87166609
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86259497
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86017158
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86002016
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85545690
139* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85045749
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84964178
141AR_21909140_ChIP-Seq_LNCAP_Human0.84930345
142MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84845297
143GATA3_26560356_Chip-Seq_TH2_Human0.83230944
144VDR_24763502_ChIP-Seq_THP-1_Human0.83219842
145BCOR_27268052_Chip-Seq_Bcells_Human0.80348518
146SCL_19346495_ChIP-Seq_HPC-7_Human0.80010023
147RUNX1_22412390_ChIP-Seq_EML_Mouse0.76557966
148* SA1_27219007_Chip-Seq_Bcells_Human0.72310580
149BCL6_27268052_Chip-Seq_Bcells_Human0.70090590
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.69591756
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.69304964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.96143257
2MP0002139_abnormal_hepatobiliary_system4.17653528
3MP0004043_abnormal_pH_regulation3.95919353
4MP0004019_abnormal_vitamin_homeostasis3.79689634
5MP0003724_increased_susceptibility_to3.64602452
6MP0002138_abnormal_hepatobiliary_system3.47084639
7MP0010234_abnormal_vibrissa_follicle3.44566625
8MP0005332_abnormal_amino_acid3.13944204
9MP0009785_altered_susceptibility_to3.13017985
10MP0004510_myositis3.12989022
11MP0009643_abnormal_urine_homeostasis3.08511269
12MP0002148_abnormal_hypersensitivity_rea3.01300435
13MP0006082_CNS_inflammation2.99324775
14MP0001765_abnormal_ion_homeostasis2.84659542
15MP0003300_gastrointestinal_ulcer2.78393860
16MP0003436_decreased_susceptibility_to2.70274941
17MP0002136_abnormal_kidney_physiology2.67068873
18MP0008875_abnormal_xenobiotic_pharmacok2.58695512
19MP0003252_abnormal_bile_duct2.57496711
20MP0003868_abnormal_feces_composition2.46836333
21MP0009840_abnormal_foam_cell2.43789766
22MP0003195_calcinosis2.35932013
23MP0005671_abnormal_response_to2.27367223
24MP0005085_abnormal_gallbladder_physiolo2.26305733
25MP0002009_preneoplasia2.25492691
26MP0005365_abnormal_bile_salt2.25292325
27MP0005636_abnormal_mineral_homeostasis2.20799847
28MP0001756_abnormal_urination2.19488748
29MP0005451_abnormal_body_composition2.18848703
30MP0005025_abnormal_response_to2.18174232
31MP0001790_abnormal_immune_system2.16407457
32MP0005387_immune_system_phenotype2.16407457
33MP0003806_abnormal_nucleotide_metabolis2.14774041
34MP0001958_emphysema2.01082380
35MP0004264_abnormal_extraembryonic_tissu1.98082301
36MP0002796_impaired_skin_barrier1.97654878
37MP0002166_altered_tumor_susceptibility1.96952593
38MP0003075_altered_response_to1.93877005
39MP0002332_abnormal_exercise_endurance1.93081607
40MP0002419_abnormal_innate_immunity1.92972455
41MP0010386_abnormal_urinary_bladder1.87573654
42MP0001533_abnormal_skeleton_physiology1.86571460
43MP0008004_abnormal_stomach_pH1.84842051
44MP0001873_stomach_inflammation1.75419356
45MP0001800_abnormal_humoral_immune1.66072389
46MP0005310_abnormal_salivary_gland1.65178009
47MP0008961_abnormal_basal_metabolism1.63893957
48MP0000604_amyloidosis1.57773196
49MP0000538_abnormal_urinary_bladder1.57503595
50* MP0001835_abnormal_antigen_presentation1.55676882
51MP0001666_abnormal_nutrient_absorption1.47969394
52MP0001853_heart_inflammation1.47773047
53MP0005167_abnormal_blood-brain_barrier1.47339011
54MP0002254_reproductive_system_inflammat1.46228680
55MP0000343_altered_response_to1.42019965
56MP0005501_abnormal_skin_physiology1.37166035
57MP0009697_abnormal_copulation1.36878988
58MP0003878_abnormal_ear_physiology1.36854726
59MP0005377_hearing/vestibular/ear_phenot1.36854726
60MP0005584_abnormal_enzyme/coenzyme_acti1.34852651
61MP0005666_abnormal_adipose_tissue1.32540421
62MP0000685_abnormal_immune_system1.31517269
63MP0004147_increased_porphyrin_level1.31209209
64MP0005166_decreased_susceptibility_to1.27884139
65MP0002928_abnormal_bile_duct1.27574041
66MP0006054_spinal_hemorrhage1.27501956
67MP0009278_abnormal_bone_marrow1.21903890
68MP0005397_hematopoietic_system_phenotyp1.21643899
69MP0001545_abnormal_hematopoietic_system1.21643899
70MP0002098_abnormal_vibrissa_morphology1.20809818
71MP0002168_other_aberrant_phenotype1.20435160
72MP0005220_abnormal_exocrine_pancreas1.17779318
73MP0002006_tumorigenesis1.17581669
74MP0009333_abnormal_splenocyte_physiolog1.15741452
75MP0004885_abnormal_endolymph1.13922363
76MP0003191_abnormal_cellular_cholesterol1.13185661
77MP0004947_skin_inflammation1.11481405
78MP0002405_respiratory_system_inflammati1.10849659
79MP0003172_abnormal_lysosome_physiology1.10160480
80MP0003448_altered_tumor_morphology1.10154843
81MP0009763_increased_sensitivity_to1.09247449
82MP0003690_abnormal_glial_cell1.07684548
83* MP0002452_abnormal_antigen_presenting1.06747832
84MP0010329_abnormal_lipoprotein_level1.06544732
85MP0005058_abnormal_lysosome_morphology1.05889453
86MP0000377_abnormal_hair_follicle1.03477104
87MP0001542_abnormal_bone_strength1.02593068
88MP0001501_abnormal_sleep_pattern1.02491196
89MP0000537_abnormal_urethra_morphology1.02170789
90MP0005319_abnormal_enzyme/_coenzyme1.01090466
91MP0005000_abnormal_immune_tolerance1.00055570
92MP0003453_abnormal_keratinocyte_physiol0.98979108
93MP0005535_abnormal_body_temperature0.98756758
94MP0000609_abnormal_liver_physiology0.97153463
95MP0001845_abnormal_inflammatory_respons0.94547665
96MP0005164_abnormal_response_to0.93587432
97MP0005408_hypopigmentation0.92558166
98MP0001216_abnormal_epidermal_layer0.91997862
99MP0002135_abnormal_kidney_morphology0.91743431
100MP0002060_abnormal_skin_morphology0.91069314
101MP0000858_altered_metastatic_potential0.90657739
102MP0003011_delayed_dark_adaptation0.90600568
103MP0002998_abnormal_bone_remodeling0.90463742
104MP0008874_decreased_physiological_sensi0.90257186
105MP0003656_abnormal_erythrocyte_physiolo0.90248723
106MP0005266_abnormal_metabolism0.88053911
107MP0009764_decreased_sensitivity_to0.87907762
108MP0002118_abnormal_lipid_homeostasis0.87696256
109MP0010678_abnormal_skin_adnexa0.87011234
110MP0004185_abnormal_adipocyte_glucose0.85748999
111MP0009384_cardiac_valve_regurgitation0.85508687
112MP0003646_muscle_fatigue0.84498233
113MP0003045_fibrosis0.82465660
114MP0010155_abnormal_intestine_physiology0.82023673
115MP0005464_abnormal_platelet_physiology0.81685541
116MP0002723_abnormal_immune_serum0.81202223
117MP0002876_abnormal_thyroid_physiology0.80418713
118MP0009765_abnormal_xenobiotic_induced0.79750432
119MP0003866_abnormal_defecation0.79153904
120MP0005165_increased_susceptibility_to0.78064875
121MP0002896_abnormal_bone_mineralization0.77384395
122MP0003566_abnormal_cell_adhesion0.77140979
123* MP0002420_abnormal_adaptive_immunity0.76372566
124MP0001879_abnormal_lymphatic_vessel0.75028722
125MP0003303_peritoneal_inflammation0.74138324
126MP0001663_abnormal_digestive_system0.73418009
127MP0005023_abnormal_wound_healing0.73200620
128MP0008469_abnormal_protein_level0.72922708
129MP0003705_abnormal_hypodermis_morpholog0.71494313
130* MP0001819_abnormal_immune_cell0.71322672
131* MP0000689_abnormal_spleen_morphology0.70800519
132MP0004883_abnormal_blood_vessel0.70231860
133MP0005376_homeostasis/metabolism_phenot0.69561638
134MP0001764_abnormal_homeostasis0.69291113
135MP0005375_adipose_tissue_phenotype0.69268957
136* MP0002398_abnormal_bone_marrow0.68934187
137MP0005670_abnormal_white_adipose0.67859463
138MP0000230_abnormal_systemic_arterial0.67828402
139MP0003091_abnormal_cell_migration0.67514914
140MP0000249_abnormal_blood_vessel0.67404756
141MP0002396_abnormal_hematopoietic_system0.67321813
142MP0003879_abnormal_hair_cell0.65683357
143MP0005390_skeleton_phenotype0.65650653
144MP0001346_abnormal_lacrimal_gland0.64394023
145MP0009642_abnormal_blood_homeostasis0.63582269
146* MP0002429_abnormal_blood_cell0.63444253
147MP0010771_integument_phenotype0.62549656
148MP0003186_abnormal_redox_activity0.62027675
149* MP0000716_abnormal_immune_system0.61470342
150MP0002722_abnormal_immune_system0.59843651
151MP0001191_abnormal_skin_condition0.58513796
152MP0005647_abnormal_sex_gland0.58303492
153MP0003183_abnormal_peptide_metabolism0.58251399
154MP0003638_abnormal_response/metabolism_0.56835544
155MP0000371_diluted_coat_color0.55944388

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.39128162
2Increased circulating renin level (HP:0000848)6.31206146
3Hypokalemic alkalosis (HP:0001949)5.95653985
4Retrobulbar optic neuritis (HP:0100654)5.68765609
5Optic neuritis (HP:0100653)5.68765609
6Hyperactive renin-angiotensin system (HP:0000841)5.67655021
7Metabolic alkalosis (HP:0200114)5.63834121
8Orchitis (HP:0100796)5.41873410
9Abnormality of chloride homeostasis (HP:0011422)5.41508169
10Gout (HP:0001997)5.41266691
11Abnormality of glycolipid metabolism (HP:0010969)5.31124053
12Abnormality of liposaccharide metabolism (HP:0010968)5.31124053
13Abnormality of glycosphingolipid metabolism (HP:0004343)5.31124053
14Hypomagnesemia (HP:0002917)5.20910152
15Polyuria (HP:0000103)4.85653807
16Abnormality of renal excretion (HP:0011036)4.74710546
17Deep venous thrombosis (HP:0002625)4.72003596
18Abnormal urine output (HP:0012590)4.69156569
19Complement deficiency (HP:0004431)4.64076578
20Proximal tubulopathy (HP:0000114)4.60109069
21Glomerulonephritis (HP:0000099)4.58774030
22Myositis (HP:0100614)4.51270584
23Abnormality of monocarboxylic acid metabolism (HP:0010996)4.37870415
24Stomatitis (HP:0010280)4.35247044
25Abnormality of magnesium homeostasis (HP:0004921)4.14666908
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04915916
27Abnormal drinking behavior (HP:0030082)3.91602788
28Polydipsia (HP:0001959)3.91602788
29Keratoconjunctivitis sicca (HP:0001097)3.90196038
30Gastrointestinal stroma tumor (HP:0100723)3.88802851
31Abnormality of renin-angiotensin system (HP:0000847)3.88506437
32Hyperglycinuria (HP:0003108)3.83450649
33Alkalosis (HP:0001948)3.81448685
34Abnormality of purine metabolism (HP:0004352)3.74896934
35Dysostosis multiplex (HP:0000943)3.72643369
36Agammaglobulinemia (HP:0004432)3.67335497
37Intrahepatic cholestasis (HP:0001406)3.67260021
38Gangrene (HP:0100758)3.65737952
39Abnormality of complement system (HP:0005339)3.61864794
40Hyperuricemia (HP:0002149)3.61763362
41Increased purine levels (HP:0004368)3.61763362
42Loss of speech (HP:0002371)3.61123210
43Tetany (HP:0001281)3.55948520
44Keratoconjunctivitis (HP:0001096)3.55905874
45Renal salt wasting (HP:0000127)3.52364083
46Disinhibition (HP:0000734)3.46801398
47Hyperaldosteronism (HP:0000859)3.45484704
48Abnormality of macrophages (HP:0004311)3.41731218
49Increased cerebral lipofuscin (HP:0011813)3.38086369
50Generalized aminoaciduria (HP:0002909)3.29659077
51Recurrent gram-negative bacterial infections (HP:0005420)3.28544653
52Dehydration (HP:0001944)3.23354804
53Abnormality of glycine metabolism (HP:0010895)3.20456071
54Abnormality of serine family amino acid metabolism (HP:0010894)3.20456071
55Increased IgM level (HP:0003496)3.15501365
56Colitis (HP:0002583)3.14470714
57Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12598127
58Prolonged partial thromboplastin time (HP:0003645)3.08135528
59Mutism (HP:0002300)3.02595818
60Recurrent bacterial skin infections (HP:0005406)3.01915075
61Nuclear cataract (HP:0100018)3.00786110
62Parakeratosis (HP:0001036)2.99813149
63Abnormality of polysaccharide metabolism (HP:0011012)2.96973116
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96973116
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96973116
66Vascular calcification (HP:0004934)2.94368532
67Hypokalemia (HP:0002900)2.86546588
68Increased serum ferritin (HP:0003281)2.85603890
69Vasculitis (HP:0002633)2.85346627
70Urinary glycosaminoglycan excretion (HP:0003541)2.84393794
71Pulmonary embolism (HP:0002204)2.83549053
72Hypercalciuria (HP:0002150)2.82961922
73Renal tubular acidosis (HP:0001947)2.82194869
74Glycosuria (HP:0003076)2.81271541
75Abnormality of urine glucose concentration (HP:0011016)2.81271541
76Recurrent abscess formation (HP:0002722)2.76974884
77IgM deficiency (HP:0002850)2.76437506
78Abnormality of proline metabolism (HP:0010907)2.75171872
79Hydroxyprolinuria (HP:0003080)2.75171872
80Pulmonary infiltrates (HP:0002113)2.73303934
81Abnormality of the fingertips (HP:0001211)2.72521544
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.71826388
83Ketoacidosis (HP:0001993)2.69931044
84Eczematoid dermatitis (HP:0000976)2.69759733
85Nephritis (HP:0000123)2.69690364
86Mediastinal lymphadenopathy (HP:0100721)2.68979432
87Ketosis (HP:0001946)2.68189269
88Abnormality of nucleobase metabolism (HP:0010932)2.67642391
89Hypobetalipoproteinemia (HP:0003563)2.66653349
90Cardiovascular calcification (HP:0011915)2.61082028
91Abnormal tarsal ossification (HP:0008369)2.59991267
92Widely patent fontanelles and sutures (HP:0004492)2.58505848
93Purpura (HP:0000979)2.57564951
94Joint swelling (HP:0001386)2.55337068
95Arterial thrombosis (HP:0004420)2.54069276
96Anorexia (HP:0002039)2.53911412
97Nausea (HP:0002018)2.53675311
98Emphysema (HP:0002097)2.53673468
99Recurrent sinusitis (HP:0011108)2.51799786
100Abnormality of potassium homeostasis (HP:0011042)2.50832584
101Inflammation of the large intestine (HP:0002037)2.50297213
102Lymphopenia (HP:0001888)2.49211193
103Malnutrition (HP:0004395)2.47537918
104IgA deficiency (HP:0002720)2.43425558
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43105539
106Rickets (HP:0002748)2.42397127
107Vacuolated lymphocytes (HP:0001922)2.41850767
108Axonal loss (HP:0003447)2.40923493
109Mitral stenosis (HP:0001718)2.39301533
110Hyperglycinemia (HP:0002154)2.37827847
111Encephalitis (HP:0002383)2.34573231
112Delayed epiphyseal ossification (HP:0002663)2.32979442
113Neurofibrillary tangles (HP:0002185)2.32633290
114Hemoptysis (HP:0002105)2.32434302
115Abnormality of iron homeostasis (HP:0011031)2.32409830
116Gastrointestinal inflammation (HP:0004386)2.31999485
117Nephrocalcinosis (HP:0000121)2.28349610
118Nephrolithiasis (HP:0000787)2.27685607
119Hypophosphatemia (HP:0002148)2.27381432
120Abnormal hemoglobin (HP:0011902)2.26830147
121Abnormality of cells of the lymphoid lineage (HP:0012140)2.26207800
122Sensorimotor neuropathy (HP:0007141)2.25371571
123Polyneuropathy (HP:0001271)2.23301046
124Recurrent bronchitis (HP:0002837)2.23114509
125Autoimmune hemolytic anemia (HP:0001890)2.22644347
126Amyloidosis (HP:0011034)2.22019731
127Reduced antithrombin III activity (HP:0001976)2.20124070
128Progressive neurologic deterioration (HP:0002344)2.19770249
129Prolonged neonatal jaundice (HP:0006579)2.17846847
130Abnormality of fatty-acid metabolism (HP:0004359)2.16770142
131Thin bony cortex (HP:0002753)2.16733410
132Chondrocalcinosis (HP:0000934)2.13552299
133Hypergammaglobulinemia (HP:0010702)2.13501425
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13017481
135Myocardial infarction (HP:0001658)2.12131985
136Abnormality of the pericardium (HP:0001697)2.10347230
137Hyperphosphaturia (HP:0003109)2.10242480
138Abnormality of the pleura (HP:0002103)2.09749992
139Abnormal enzyme/coenzyme activity (HP:0012379)2.09576978
140Hyperammonemia (HP:0001987)2.08897172
141Abnormal urine phosphate concentration (HP:0012599)2.08146175
142Elevated alkaline phosphatase (HP:0003155)2.07773159
143Metaphyseal irregularity (HP:0003025)2.06579043
144Abnormal foot bone ossification (HP:0010675)2.06238531
145Chronic diarrhea (HP:0002028)2.04151905
146Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03531681
147Abnormality of pyrimidine metabolism (HP:0004353)2.02316129
148Abnormality of Sharpey fibers (HP:0100685)2.01708201
149Abnormality of alkaline phosphatase activity (HP:0004379)2.01668694
150Facial shape deformation (HP:0011334)2.01567155
151Potter facies (HP:0002009)2.01567155
152Abnormality of the common coagulation pathway (HP:0010990)2.01025269
153Recurrent viral infections (HP:0004429)2.00659685
154Abnormality of carpal bone ossification (HP:0006257)2.00462603
155Basal ganglia calcification (HP:0002135)2.00130551
156Steatorrhea (HP:0002570)2.00103527
157Fat malabsorption (HP:0002630)1.99499765
158Lymphangioma (HP:0100764)1.99433436
159Xanthomatosis (HP:0000991)1.99294543
160Cellulitis (HP:0100658)1.99065573
161Thrombophlebitis (HP:0004418)1.98894935
162Elevated erythrocyte sedimentation rate (HP:0003565)1.98742394
163Memory impairment (HP:0002354)1.98585432
164Hematochezia (HP:0002573)1.98098118
165Verrucae (HP:0200043)1.97784283
166Papilloma (HP:0012740)1.97784283
167Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95956150
168Meningitis (HP:0001287)1.93123960
169Hyponatremia (HP:0002902)1.92218315
170Acne (HP:0001061)1.92146340
171Abnormality of transition element cation homeostasis (HP:0011030)1.91663693
172Petechiae (HP:0000967)1.90441108
173Autoimmune thrombocytopenia (HP:0001973)1.90008041
174Abnormality of sulfur amino acid metabolism (HP:0004339)1.89225208
175Apathy (HP:0000741)1.88974032
176Pancreatitis (HP:0001733)1.87194562
177Small epiphyses (HP:0010585)1.87093506
178Arthralgia (HP:0002829)1.87042617
179Confusion (HP:0001289)1.85515794
180Bilateral sensorineural hearing impairment (HP:0008619)1.84659814
181Tubulointerstitial fibrosis (HP:0005576)1.84083604
182Metaphyseal cupping (HP:0003021)1.82236018
183Protuberant abdomen (HP:0001538)1.81408436
184Restrictive lung disease (HP:0002091)1.81312476
185Lip pit (HP:0100267)1.81081340
186Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80480628
187Interstitial pulmonary disease (HP:0006530)1.79944927
188Mucopolysacchariduria (HP:0008155)1.78790250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.85237582
2OXSR15.08164603
3STK394.45319675
4GRK73.85050643
5NME23.64262937
6RIPK13.51864978
7WNK33.48530878
8TAOK23.24747751
9MAP4K13.13651327
10ERN13.12839566
11DDR22.69997024
12PIM22.62293201
13MST42.52575097
14IKBKE2.47670393
15MOS2.44123943
16PRPF4B2.42858892
17LRRK22.29797959
18MATK2.27575670
19IRAK42.26223774
20LATS12.22305798
21GRK62.08815846
22MAP3K112.00438475
23TNK21.98453768
24BMPR21.96669126
25GRK11.96260598
26BCKDK1.81946658
27STK101.78236775
28WNK11.72634208
29TXK1.64121558
30MST1R1.62037834
31STK38L1.61860461
32CLK11.56885490
33MAP3K101.55002041
34CDK121.52958658
35FGFR41.47616125
36ADRBK21.40634217
37JAK11.40209412
38SIK11.37366017
39FGR1.36868903
40LATS21.35222679
41RIPK41.34939916
42MAP3K141.33622115
43MAP3K131.31167296
44PTK61.29256548
45BLK1.28699934
46IRAK11.25432907
47TAOK31.21649701
48FER1.21185312
49FRK1.19693877
50ACVR1B1.18882946
51TYK21.18548041
52BTK1.14954583
53CAMK1D1.07834347
54IRAK31.03979042
55TGFBR21.03276500
56ABL21.02668146
57PDK31.02046400
58PDK41.02046400
59MAP3K51.01439019
60IRAK21.01258115
61CSF1R0.98640434
62MAP3K70.98430221
63CAMK1G0.94673940
64PDK20.93747435
65ZAP700.92415517
66SIK20.91514553
67EEF2K0.90438279
68MAP3K10.90136254
69SYK0.89471366
70DYRK30.85548163
71MAP2K60.82668652
72MAP3K20.81066135
73STK380.79769693
74CDK60.79499849
75TESK20.75267787
76EPHB10.74330539
77EPHA30.73071597
78LCK0.70178072
79ITK0.69346696
80MAP3K30.69149800
81PKN10.68993236
82TRIB30.67892835
83SGK2230.67398774
84SGK4940.67398774
85TYRO30.66252690
86CSK0.66061800
87MAPK110.65120473
88PIK3CG0.64265361
89DYRK1B0.64181831
90SGK30.64148790
91HIPK20.64038482
92PDK10.63382483
93PRKD20.62069286
94BRD40.61712004
95PRKAA20.61372385
96MAPKAPK30.59563146
97LMTK20.58989946
98MAPK40.56957747
99MAPK120.52089673
100PRKCH0.51699902
101PDPK10.51686530
102BMX0.50930950
103CDK40.50333311
104CDC42BPA0.49922274
105TEC0.49518999
106LYN0.49202531
107TAOK10.49112589
108EIF2AK30.49064789
109JAK20.48379487
110PRKD10.47931967
111JAK30.47839067
112PKN20.47760538
113PRKAA10.47463199
114INSRR0.46657188
115STK30.46522163
116SGK20.46366731
117MARK30.45848070
118FGFR30.45665660
119PRKCQ0.44794651
120NEK90.43751572
121ABL10.42902975
122MTOR0.42340615
123PDGFRA0.41871918
124CHUK0.39607359
125INSR0.39499146
126TESK10.38601367
127DAPK30.37276768
128EIF2AK20.37126386
129GSK3A0.36626350
130KIT0.36181903
131HCK0.35894850
132FGFR20.35305002
133TBK10.34035832
134SGK10.33606813
135KDR0.33572383
136EGFR0.32094994
137PDGFRB0.31615825
138ARAF0.31583547
139CDK90.31559060
140IKBKB0.30881100
141PRKACG0.28843402
142MAPK70.26579425
143PRKCI0.26357529
144TLK10.26311838
145ICK0.25553809
146CDK140.25461128
147DAPK20.25231536
148STK110.24284229
149GRK50.24202909
150CDK150.23821362
151MAP2K30.22886210
152PIM10.22692222
153MAPKAPK20.22416308
154CDK11A0.22334605
155CDK180.18299647
156FYN0.17917919
157PRKCD0.17370450
158STK240.16966300
159CAMKK20.16593020
160MAPK30.16088626
161SIK30.13901046

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20235470
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.01020348
3Butanoate metabolism_Homo sapiens_hsa006502.86048018
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84139149
5Propanoate metabolism_Homo sapiens_hsa006402.75879457
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.73652046
7Staphylococcus aureus infection_Homo sapiens_hsa051502.60990121
8Allograft rejection_Homo sapiens_hsa053302.58567959
9Asthma_Homo sapiens_hsa053102.56524100
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56415361
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54186715
12Fatty acid degradation_Homo sapiens_hsa000712.44814475
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27818454
14Pertussis_Homo sapiens_hsa051332.23196440
15African trypanosomiasis_Homo sapiens_hsa051432.21504666
16Tryptophan metabolism_Homo sapiens_hsa003802.18237305
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18123399
18Malaria_Homo sapiens_hsa051442.10502236
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10065465
20B cell receptor signaling pathway_Homo sapiens_hsa046622.04734469
21Vitamin digestion and absorption_Homo sapiens_hsa049772.01516551
22Rheumatoid arthritis_Homo sapiens_hsa053231.97843144
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95234722
24beta-Alanine metabolism_Homo sapiens_hsa004101.94956390
25Pyruvate metabolism_Homo sapiens_hsa006201.94510978
26Autoimmune thyroid disease_Homo sapiens_hsa053201.94270794
27Peroxisome_Homo sapiens_hsa041461.94058223
28Lysine degradation_Homo sapiens_hsa003101.91015799
29TNF signaling pathway_Homo sapiens_hsa046681.90989705
30Leishmaniasis_Homo sapiens_hsa051401.87662766
31Graft-versus-host disease_Homo sapiens_hsa053321.76267084
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72273938
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71696353
34Fatty acid metabolism_Homo sapiens_hsa012121.71645286
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66494576
36Primary immunodeficiency_Homo sapiens_hsa053401.64027327
37Bile secretion_Homo sapiens_hsa049761.63282964
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.60709895
39PPAR signaling pathway_Homo sapiens_hsa033201.59461423
40Sulfur metabolism_Homo sapiens_hsa009201.57613729
41Prion diseases_Homo sapiens_hsa050201.56213369
42Other glycan degradation_Homo sapiens_hsa005111.50274891
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.44707713
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42880070
45Histidine metabolism_Homo sapiens_hsa003401.42795769
46Mineral absorption_Homo sapiens_hsa049781.41368451
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41101283
48Influenza A_Homo sapiens_hsa051641.41014730
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39796868
50Legionellosis_Homo sapiens_hsa051341.36335991
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35258029
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30792211
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30408541
54Type I diabetes mellitus_Homo sapiens_hsa049401.26030950
55Nitrogen metabolism_Homo sapiens_hsa009101.25619357
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23433113
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21806505
58ABC transporters_Homo sapiens_hsa020101.20129457
59Arginine biosynthesis_Homo sapiens_hsa002201.17618013
60Collecting duct acid secretion_Homo sapiens_hsa049661.17012720
61Protein digestion and absorption_Homo sapiens_hsa049741.16779930
62Toxoplasmosis_Homo sapiens_hsa051451.16051755
63Glycerolipid metabolism_Homo sapiens_hsa005611.14361237
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.13273992
65Phenylalanine metabolism_Homo sapiens_hsa003601.12026475
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10622543
67Hematopoietic cell lineage_Homo sapiens_hsa046401.09923289
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09163589
69Salmonella infection_Homo sapiens_hsa051321.02459817
70Measles_Homo sapiens_hsa051621.01539863
71Renin-angiotensin system_Homo sapiens_hsa046140.98599496
72Herpes simplex infection_Homo sapiens_hsa051680.98326054
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96940081
74Sphingolipid metabolism_Homo sapiens_hsa006000.94800162
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94582970
76Arginine and proline metabolism_Homo sapiens_hsa003300.94150291
77Starch and sucrose metabolism_Homo sapiens_hsa005000.93680489
78Caffeine metabolism_Homo sapiens_hsa002320.92951588
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90185300
80Carbon metabolism_Homo sapiens_hsa012000.84456646
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.82143688
82Linoleic acid metabolism_Homo sapiens_hsa005910.81510895
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80131444
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79482849
85Viral myocarditis_Homo sapiens_hsa054160.78427099
86Glutathione metabolism_Homo sapiens_hsa004800.77745515
87Thyroid hormone synthesis_Homo sapiens_hsa049180.77239766
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74709919
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73261259
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.73101735
91Fructose and mannose metabolism_Homo sapiens_hsa000510.72436802
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71841483
93Insulin resistance_Homo sapiens_hsa049310.70283442
94Arachidonic acid metabolism_Homo sapiens_hsa005900.68582199
95Folate biosynthesis_Homo sapiens_hsa007900.67999917
96Selenocompound metabolism_Homo sapiens_hsa004500.67698470
97Amoebiasis_Homo sapiens_hsa051460.64786846
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63425169
99Chemokine signaling pathway_Homo sapiens_hsa040620.63394892
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61059022
101Chemical carcinogenesis_Homo sapiens_hsa052040.60495349
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.59691817
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.59618856
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58780582
105Hepatitis B_Homo sapiens_hsa051610.57767266
106Lysosome_Homo sapiens_hsa041420.53441620
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.53109435
108Phagosome_Homo sapiens_hsa041450.51467284
109Fatty acid biosynthesis_Homo sapiens_hsa000610.50702324
110Complement and coagulation cascades_Homo sapiens_hsa046100.50074363
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.49833576
112Prolactin signaling pathway_Homo sapiens_hsa049170.48960935
113Retinol metabolism_Homo sapiens_hsa008300.48794411
114Hepatitis C_Homo sapiens_hsa051600.47812088
115Pentose phosphate pathway_Homo sapiens_hsa000300.47382453
116Epstein-Barr virus infection_Homo sapiens_hsa051690.46044218
117Inositol phosphate metabolism_Homo sapiens_hsa005620.45673585
118Fat digestion and absorption_Homo sapiens_hsa049750.45016711
119Systemic lupus erythematosus_Homo sapiens_hsa053220.44917241
120Apoptosis_Homo sapiens_hsa042100.44283378
121Gastric acid secretion_Homo sapiens_hsa049710.43795044
122Type II diabetes mellitus_Homo sapiens_hsa049300.43736116
123Adherens junction_Homo sapiens_hsa045200.40590033
124Shigellosis_Homo sapiens_hsa051310.40367808
125Choline metabolism in cancer_Homo sapiens_hsa052310.39250690
126Galactose metabolism_Homo sapiens_hsa000520.35331191
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34705962
128Acute myeloid leukemia_Homo sapiens_hsa052210.33847542
129T cell receptor signaling pathway_Homo sapiens_hsa046600.32786218
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32404237
131Sulfur relay system_Homo sapiens_hsa041220.31357674
132Pancreatic secretion_Homo sapiens_hsa049720.30339318
133Bladder cancer_Homo sapiens_hsa052190.30204056
134Osteoclast differentiation_Homo sapiens_hsa043800.28192221
135Tyrosine metabolism_Homo sapiens_hsa003500.28083211
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27689793
137AMPK signaling pathway_Homo sapiens_hsa041520.27442550
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26499283
139Prostate cancer_Homo sapiens_hsa052150.26338979
140Glucagon signaling pathway_Homo sapiens_hsa049220.26318699
141Non-small cell lung cancer_Homo sapiens_hsa052230.24970050
142Fatty acid elongation_Homo sapiens_hsa000620.23900036
143FoxO signaling pathway_Homo sapiens_hsa040680.21874785
144Biosynthesis of amino acids_Homo sapiens_hsa012300.20233465
145Small cell lung cancer_Homo sapiens_hsa052220.19805176
146Pancreatic cancer_Homo sapiens_hsa052120.19057859
147Tuberculosis_Homo sapiens_hsa051520.17561057
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.17524621
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.17243922
150Antigen processing and presentation_Homo sapiens_hsa046120.16990815
151Metabolic pathways_Homo sapiens_hsa011000.15303902

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