FCAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)6.48245511
2response to peptidoglycan (GO:0032494)5.70584856
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.76242651
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.76242651
5modulation by symbiont of host immune response (GO:0052553)4.76242651
6positive regulation by symbiont of host defense response (GO:0052509)4.76242651
7modulation by symbiont of host defense response (GO:0052031)4.76242651
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.76242651
9negative regulation of interleukin-12 production (GO:0032695)4.75622365
10neutrophil mediated immunity (GO:0002446)4.70063931
11neutrophil activation involved in immune response (GO:0002283)4.58919748
12positive regulation of gamma-delta T cell activation (GO:0046645)4.48468302
13microglial cell activation (GO:0001774)4.41110874
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.28114338
15neutrophil activation (GO:0042119)4.26875928
16detection of molecule of bacterial origin (GO:0032490)4.25597067
17leukocyte aggregation (GO:0070486)4.13990168
18macrophage activation involved in immune response (GO:0002281)4.12357954
19detection of other organism (GO:0098543)4.07554841
20negative regulation of interleukin-1 production (GO:0032692)4.07493808
21negative regulation of cell killing (GO:0031342)4.06472542
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06472542
23negative regulation of interleukin-1 beta production (GO:0032691)4.05811637
24respiratory burst (GO:0045730)3.96741457
25leukocyte migration involved in inflammatory response (GO:0002523)3.94213984
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94190757
27response to host immune response (GO:0052572)3.94190757
28granulocyte activation (GO:0036230)3.92777088
29positive regulation of mast cell activation (GO:0033005)3.86885042
30regulation of mast cell activation (GO:0033003)3.84827609
31macrophage activation (GO:0042116)3.84259114
32myeloid leukocyte mediated immunity (GO:0002444)3.80996917
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.77287488
34regulation of interferon-beta biosynthetic process (GO:0045357)3.71436426
35regulation of B cell receptor signaling pathway (GO:0050855)3.65925280
36defense response to fungus (GO:0050832)3.65575067
37detection of external biotic stimulus (GO:0098581)3.63868968
38detection of biotic stimulus (GO:0009595)3.60332541
39detection of bacterium (GO:0016045)3.58244876
40regulation of gamma-delta T cell activation (GO:0046643)3.55402199
41positive regulation of toll-like receptor signaling pathway (GO:0034123)3.55115939
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.48882962
43neutrophil chemotaxis (GO:0030593)3.42115744
44response to host defenses (GO:0052200)3.40662931
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40662931
46response to host (GO:0075136)3.40662931
47negative regulation of interleukin-6 production (GO:0032715)3.39620585
48production of molecular mediator involved in inflammatory response (GO:0002532)3.38713125
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.35555536
50positive regulation of mast cell degranulation (GO:0043306)3.35555536
51disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.34679760
52killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.34679760
53neutrophil migration (GO:1990266)3.33763601
54myeloid cell activation involved in immune response (GO:0002275)3.31545731
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30340244
56response to fungus (GO:0009620)3.28776220
57regulation of interleukin-6 biosynthetic process (GO:0045408)3.27234521
58regulation of growth of symbiont in host (GO:0044126)3.26268133
59negative regulation of growth of symbiont in host (GO:0044130)3.26268133
60negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.26268133
61modulation of growth of symbiont involved in interaction with host (GO:0044144)3.26268133
62regulation of mast cell degranulation (GO:0043304)3.25014462
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24499949
64killing of cells of other organism (GO:0031640)3.23822471
65disruption of cells of other organism (GO:0044364)3.23822471
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23808063
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.23630617
68negative regulation of T cell mediated immunity (GO:0002710)3.20412086
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.17623606
70positive regulation of interleukin-1 beta secretion (GO:0050718)3.17157090
71immunoglobulin mediated immune response (GO:0016064)3.15433846
72superoxide anion generation (GO:0042554)3.12264197
73regulation of mast cell activation involved in immune response (GO:0033006)3.11633635
74activated T cell proliferation (GO:0050798)3.10720649
75interferon-gamma production (GO:0032609)3.08474688
76regulation of interleukin-8 biosynthetic process (GO:0045414)3.07543484
77granulocyte chemotaxis (GO:0071621)3.01286824
78defense response to protozoan (GO:0042832)3.00635592
79leukocyte degranulation (GO:0043299)2.99529618
80mast cell activation (GO:0045576)2.97421385
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95898305
82positive regulation of interleukin-1 secretion (GO:0050716)2.94401336
83granulocyte migration (GO:0097530)2.93538346
84regulation of MHC class II biosynthetic process (GO:0045346)2.91039310
85positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89648294
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87564396
87reactive oxygen species biosynthetic process (GO:1903409)2.85987399
88regulation of interleukin-1 beta secretion (GO:0050706)2.84308504
89response to protozoan (GO:0001562)2.83356399
90cytokine secretion (GO:0050663)2.81102895
91response to muramyl dipeptide (GO:0032495)2.80954289
92fucose catabolic process (GO:0019317)2.80841785
93L-fucose metabolic process (GO:0042354)2.80841785
94L-fucose catabolic process (GO:0042355)2.80841785
95myeloid leukocyte activation (GO:0002274)2.78419215
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78282619
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.73807211
98negative regulation of interleukin-8 production (GO:0032717)2.72178703
99hydrogen peroxide biosynthetic process (GO:0050665)2.71430949
100negative regulation of T-helper cell differentiation (GO:0045623)2.69095591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.63804106
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.47309236
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.99366572
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51349574
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.88259531
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72956224
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54941033
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51556350
9RUNX_20019798_ChIP-Seq_JUKART_Human2.34574183
10ZNF274_21170338_ChIP-Seq_K562_Hela2.33369241
11VDR_24787735_ChIP-Seq_THP-1_Human2.24208712
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21781269
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15206763
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04335898
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.04245337
16* SPI1_23547873_ChIP-Seq_NB4_Human1.97311024
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93866322
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83198268
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79193627
20GATA3_26560356_Chip-Seq_TH2_Human1.78164003
21SCL_19346495_ChIP-Seq_HPC-7_Human1.77102247
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71921010
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71767195
24SPI1_23127762_ChIP-Seq_K562_Human1.68328468
25MYB_26560356_Chip-Seq_TH2_Human1.66672840
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64379415
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.63450496
28IGF1R_20145208_ChIP-Seq_DFB_Human1.60042262
29VDR_24763502_ChIP-Seq_THP-1_Human1.57221691
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.53535376
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51538289
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49759560
33VDR_22108803_ChIP-Seq_LS180_Human1.48359073
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47903939
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46996482
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46179555
37ER_23166858_ChIP-Seq_MCF-7_Human1.45322798
38GBX2_23144817_ChIP-Seq_PC3_Human1.38192363
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37695462
40GATA3_27048872_Chip-Seq_THYMUS_Human1.37659396
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36168140
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36140941
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35179021
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29917581
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23875014
46SMRT_27268052_Chip-Seq_Bcells_Human1.21619272
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20892239
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17421878
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.17339614
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14990203
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13950345
52BCAT_22108803_ChIP-Seq_LS180_Human1.13806709
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13229742
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12876303
55MYB_26560356_Chip-Seq_TH1_Human1.12446841
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.10756996
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10582409
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09627277
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09584478
60GATA1_22025678_ChIP-Seq_K562_Human1.08003964
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06793817
62EZH2_22144423_ChIP-Seq_EOC_Human1.05539377
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03358900
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02193968
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01924428
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.01366100
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00767406
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.00764989
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00710291
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00710291
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00289141
72EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99742206
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98902970
74PU_27001747_Chip-Seq_BMDM_Mouse0.97141248
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96745681
76POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95557112
77FLI1_21867929_ChIP-Seq_TH2_Mouse0.93956378
78TP53_22573176_ChIP-Seq_HFKS_Human0.92786265
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91682528
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89850182
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89703895
82MAF_26560356_Chip-Seq_TH1_Human0.89624481
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89225397
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88902009
85P300_19829295_ChIP-Seq_ESCs_Human0.88769331
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88484946
87IRF1_19129219_ChIP-ChIP_H3396_Human0.88470095
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87911229
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87714602
90NANOG_19829295_ChIP-Seq_ESCs_Human0.87379267
91SOX2_19829295_ChIP-Seq_ESCs_Human0.87379267
92* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86535530
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85198675
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85103054
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84868257
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83548642
97GATA3_26560356_Chip-Seq_TH1_Human0.83325390
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82879791
99* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82463228
100* FOXA1_25329375_ChIP-Seq_VCAP_Human0.82463228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.81643631
2MP0003303_peritoneal_inflammation3.78214729
3MP0003436_decreased_susceptibility_to3.62804520
4MP0009785_altered_susceptibility_to3.26111469
5MP0001835_abnormal_antigen_presentation3.11922082
6MP0002419_abnormal_innate_immunity3.10877292
7MP0002148_abnormal_hypersensitivity_rea2.89012514
8MP0005671_abnormal_response_to2.72543597
9MP0005025_abnormal_response_to2.64178074
10MP0005000_abnormal_immune_tolerance2.62903363
11MP0001800_abnormal_humoral_immune2.55789794
12MP0009764_decreased_sensitivity_to2.55638666
13MP0006082_CNS_inflammation2.46591155
14MP0000685_abnormal_immune_system2.42900219
15MP0005387_immune_system_phenotype2.42510991
16MP0001790_abnormal_immune_system2.42510991
17MP0002723_abnormal_immune_serum2.39094381
18MP0002452_abnormal_antigen_presenting2.36933371
19MP0002420_abnormal_adaptive_immunity2.22606140
20MP0001819_abnormal_immune_cell2.20073726
21MP0009278_abnormal_bone_marrow2.17538564
22MP0003195_calcinosis2.08992777
23MP0000569_abnormal_digit_pigmentation2.06742620
24MP0001533_abnormal_skeleton_physiology1.98936743
25MP0002277_abnormal_respiratory_mucosa1.89050919
26MP0005167_abnormal_blood-brain_barrier1.80415830
27MP0001845_abnormal_inflammatory_respons1.78825487
28MP0002405_respiratory_system_inflammati1.76716808
29MP0003828_pulmonary_edema1.60305539
30MP0000716_abnormal_immune_system1.53632593
31MP0005464_abnormal_platelet_physiology1.51420197
32MP0003172_abnormal_lysosome_physiology1.48503805
33MP0008469_abnormal_protein_level1.45349302
34MP0003075_altered_response_to1.42307341
35MP0002138_abnormal_hepatobiliary_system1.41189454
36MP0005310_abnormal_salivary_gland1.37731075
37MP0010155_abnormal_intestine_physiology1.37215983
38MP0001986_abnormal_taste_sensitivity1.34062603
39MP0002398_abnormal_bone_marrow1.33556731
40MP0004947_skin_inflammation1.32297956
41MP0001545_abnormal_hematopoietic_system1.31230322
42MP0005397_hematopoietic_system_phenotyp1.31230322
43MP0000689_abnormal_spleen_morphology1.22480536
44MP0004510_myositis1.19841893
45MP0003646_muscle_fatigue1.18786675
46MP0000343_altered_response_to1.18713506
47MP0002132_abnormal_respiratory_system1.17888922
48MP0003300_gastrointestinal_ulcer1.13896228
49MP0003656_abnormal_erythrocyte_physiolo1.13356674
50MP0002429_abnormal_blood_cell1.10990731
51MP0002722_abnormal_immune_system1.09874707
52MP0000465_gastrointestinal_hemorrhage1.08294765
53MP0005164_abnormal_response_to1.07514026
54MP0001501_abnormal_sleep_pattern1.03046694
55MP0001663_abnormal_digestive_system1.02330872
56MP0008004_abnormal_stomach_pH1.00812915
57MP0008875_abnormal_xenobiotic_pharmacok0.99872170
58MP0009765_abnormal_xenobiotic_induced0.98056854
59MP0004883_abnormal_blood_vessel0.97400892
60MP0005166_decreased_susceptibility_to0.94349959
61MP0009333_abnormal_splenocyte_physiolog0.92296299
62MP0002998_abnormal_bone_remodeling0.91110994
63MP0005174_abnormal_tail_pigmentation0.90746801
64MP0001853_heart_inflammation0.88963526
65MP0003866_abnormal_defecation0.88475963
66MP0003763_abnormal_thymus_physiology0.87612895
67MP0002653_abnormal_ependyma_morphology0.87610142
68MP0008877_abnormal_DNA_methylation0.87458629
69MP0003806_abnormal_nucleotide_metabolis0.87147776
70MP0000015_abnormal_ear_pigmentation0.85480582
71MP0005083_abnormal_biliary_tract0.84594101
72MP0002332_abnormal_exercise_endurance0.84542876
73MP0002254_reproductive_system_inflammat0.82642810
74MP0001873_stomach_inflammation0.82605140
75MP0005075_abnormal_melanosome_morpholog0.82354354
76MP0002006_tumorigenesis0.81995739
77MP0004142_abnormal_muscle_tone0.81887897
78MP0002693_abnormal_pancreas_physiology0.80812501
79MP0009763_increased_sensitivity_to0.80663140
80MP0004484_altered_response_of0.80206013
81MP0003252_abnormal_bile_duct0.79009167
82MP0003045_fibrosis0.78300156
83MP0003690_abnormal_glial_cell0.77368566
84MP0004043_abnormal_pH_regulation0.76186024
85MP0005390_skeleton_phenotype0.74030788
86MP0008872_abnormal_physiological_respon0.73802103
87MP0001851_eye_inflammation0.73722256
88MP0008961_abnormal_basal_metabolism0.73608404
89MP0003191_abnormal_cellular_cholesterol0.71597383
90MP0004381_abnormal_hair_follicle0.70949797
91MP0000703_abnormal_thymus_morphology0.70733849
92MP0005084_abnormal_gallbladder_morpholo0.69840500
93MP0003787_abnormal_imprinting0.68324330
94MP0003011_delayed_dark_adaptation0.68266532
95MP0005535_abnormal_body_temperature0.66279695
96MP0003183_abnormal_peptide_metabolism0.65906550
97MP0004742_abnormal_vestibular_system0.65652691
98MP0004130_abnormal_muscle_cell0.64865844
99MP0000604_amyloidosis0.63712480
100MP0003448_altered_tumor_morphology0.62578520

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.20848389
2Retrobulbar optic neuritis (HP:0100654)5.57679299
3Optic neuritis (HP:0100653)5.57679299
4Myositis (HP:0100614)5.43906974
5Orchitis (HP:0100796)5.33361198
6Recurrent bacterial skin infections (HP:0005406)4.96795316
7Elevated erythrocyte sedimentation rate (HP:0003565)4.95446893
8Recurrent abscess formation (HP:0002722)4.73870783
9Abnormality of macrophages (HP:0004311)4.50898222
10Eczematoid dermatitis (HP:0000976)4.49442058
11Recurrent gram-negative bacterial infections (HP:0005420)3.91202733
12Keratoconjunctivitis sicca (HP:0001097)3.79281128
13Keratoconjunctivitis (HP:0001096)3.77887205
14Recurrent fungal infections (HP:0002841)3.72730058
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.51017295
16Encephalitis (HP:0002383)3.45516637
17Mediastinal lymphadenopathy (HP:0100721)3.42300546
18Chronic mucocutaneous candidiasis (HP:0002728)3.38358840
19Recurrent cutaneous fungal infections (HP:0011370)3.38358840
20Episodic fever (HP:0001954)3.36112347
21Recurrent skin infections (HP:0001581)3.36079054
22Hemoptysis (HP:0002105)3.26860967
23Chronic obstructive pulmonary disease (HP:0006510)3.12175377
24Obstructive lung disease (HP:0006536)3.12175377
25Gastrointestinal infarctions (HP:0005244)3.11366069
26Vasculitis (HP:0002633)3.06968181
27Pulmonary infiltrates (HP:0002113)2.97117235
28Meningitis (HP:0001287)2.96403042
29Increased cerebral lipofuscin (HP:0011813)2.85576171
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.84819180
31Leukocytosis (HP:0001974)2.84072579
32Urticaria (HP:0001025)2.79846734
33Gangrene (HP:0100758)2.79761563
34Congenital stationary night blindness (HP:0007642)2.73690029
35Anorexia (HP:0002039)2.71473987
36Amyloidosis (HP:0011034)2.70122164
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53918285
38Arterial thrombosis (HP:0004420)2.47867047
39Pancreatic cysts (HP:0001737)2.45051154
40Abnormality of the pleura (HP:0002103)2.35972047
41Stomach cancer (HP:0012126)2.35628450
42Abolished electroretinogram (ERG) (HP:0000550)2.34990884
43Autoimmune thrombocytopenia (HP:0001973)2.33521961
44Chest pain (HP:0100749)2.32612436
45Attenuation of retinal blood vessels (HP:0007843)2.31271018
46Abnormality of T cell number (HP:0011839)2.30415470
47Hematochezia (HP:0002573)2.25406596
48Pulmonary embolism (HP:0002204)2.24238962
49Polyneuropathy (HP:0001271)2.23317582
50Prolonged bleeding time (HP:0003010)2.21507048
51Abnormal rod and cone electroretinograms (HP:0008323)2.21443193
52Hypochromic microcytic anemia (HP:0004840)2.18024507
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16293374
54Vacuolated lymphocytes (HP:0001922)2.16112034
55Abnormality of glycolipid metabolism (HP:0010969)2.15865101
56Abnormality of liposaccharide metabolism (HP:0010968)2.15865101
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.15865101
58Hypochromic anemia (HP:0001931)2.15690799
59T lymphocytopenia (HP:0005403)2.14822728
60Pustule (HP:0200039)2.14639681
61Abnormality of T cells (HP:0002843)2.14217720
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10374904
63Gingivitis (HP:0000230)2.07602411
64Abnormality of T cell physiology (HP:0011840)2.07183302
65Abnormality of transition element cation homeostasis (HP:0011030)2.05139090
66Decreased central vision (HP:0007663)2.04006744
67Vertigo (HP:0002321)2.02711981
68Abnormality of midbrain morphology (HP:0002418)2.01783607
69Molar tooth sign on MRI (HP:0002419)2.01783607
70Keratitis (HP:0000491)2.01553417
71Constricted visual fields (HP:0001133)2.00392303
72Eosinophilia (HP:0001880)1.99865078
73Increased serum ferritin (HP:0003281)1.98345742
74Abnormality of eosinophils (HP:0001879)1.98099836
75Progressive inability to walk (HP:0002505)1.94702288
76True hermaphroditism (HP:0010459)1.93819519
77Abnormality of iron homeostasis (HP:0011031)1.93608212
78Pancreatic fibrosis (HP:0100732)1.93013186
79Clumsiness (HP:0002312)1.91145930
80Increased IgE level (HP:0003212)1.89577718
81Spontaneous hematomas (HP:0007420)1.89561825
82Abnormality of the endocardium (HP:0004306)1.88012910
83Panhypogammaglobulinemia (HP:0003139)1.86890598
84Recurrent viral infections (HP:0004429)1.86723591
85Cheilitis (HP:0100825)1.84711419
86Agitation (HP:0000713)1.84238625
87Abnormality of the pericardium (HP:0001697)1.81354562
88Hyperventilation (HP:0002883)1.81351958
89Granulocytopenia (HP:0001913)1.80458727
90Gingival bleeding (HP:0000225)1.75491248
91Genetic anticipation (HP:0003743)1.75442808
92Epistaxis (HP:0000421)1.74272636
93Acne (HP:0001061)1.72130076
94Inability to walk (HP:0002540)1.72110202
95Absent/shortened dynein arms (HP:0200106)1.72043456
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.72043456
97Abnormality of B cell number (HP:0010975)1.70903921
98Petechiae (HP:0000967)1.70762248
99Increased IgM level (HP:0003496)1.70092061
100Progressive cerebellar ataxia (HP:0002073)1.68200002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.44777540
2BLK3.24344374
3TXK3.16111362
4IRAK43.02028856
5FRK2.93653443
6TAOK32.59907882
7MAP4K12.51719562
8ADRBK22.30909851
9IRAK32.29511921
10CSK2.17023609
11IRAK12.11530615
12ACVR1B1.93897386
13FES1.93358583
14MAP2K31.88062989
15IKBKE1.85832115
16ZAP701.79694317
17GRK61.74088741
18SYK1.71779922
19TYK21.70840600
20MAP3K141.69476430
21IKBKB1.67703138
22CAMKK21.66628979
23DAPK21.66466004
24KIT1.58326289
25MATK1.56744948
26TNK21.51724141
27FGR1.47684269
28BMPR1B1.41239050
29LYN1.34699269
30BMPR21.32185032
31HCK1.25593588
32BTK1.23898766
33JAK31.23824013
34CAMK1D1.23549422
35IRAK21.17979188
36TEC1.17731061
37TAOK11.13044708
38TBK11.12495022
39MAP3K111.09586110
40JAK21.07868481
41GRK11.07658684
42CHUK1.06727540
43PIK3CG1.05055477
44GRK71.01696354
45ITK0.97054557
46LCK0.95686572
47MARK30.94417993
48INSRR0.89234211
49MAP2K60.88283752
50MAP3K30.87778736
51EPHB10.86164684
52WNK30.84304487
53MAP4K20.81568343
54TLK10.81045243
55PINK10.81000280
56SIK20.78755648
57PTK2B0.77921459
58JAK10.77879631
59CSF1R0.77643926
60OXSR10.77249380
61SIK30.76336162
62EPHA30.75388104
63ADRBK10.74917966
64WNK40.72866204
65NUAK10.71325833
66MAP3K10.70428014
67ERN10.70382759
68STK110.68141747
69MAPK130.65005245
70MAP2K40.62268648
71CAMK1G0.60423774
72PRKCQ0.57908231
73MAP3K20.56631481
74WNK10.54809743
75PDK10.53102133
76YES10.53053069
77ZAK0.52273158
78TGFBR20.51228384
79PAK30.49302722
80KSR20.47633380
81RPS6KA60.46910935
82CAMK40.45593774
83PIM10.44864979
84CAMK10.43488481
85MAP3K70.43362908
86PRKAA20.42358720
87MAP3K50.42294029
88PIK3CA0.41500000
89SGK20.39678054
90PRKD20.38371603
91MARK20.38217434
92ABL10.38180023
93MAPK120.37859915
94MAPK70.37657065
95STK240.37497655
96TRPM70.35612067
97FYN0.34578362
98TGFBR10.34437772
99PRKCZ0.33615013
100HIPK20.32789620

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.96182134
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.89366476
3Osteoclast differentiation_Homo sapiens_hsa043802.77930601
4* Staphylococcus aureus infection_Homo sapiens_hsa051502.50207627
5Graft-versus-host disease_Homo sapiens_hsa053322.43219885
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41766490
7Tuberculosis_Homo sapiens_hsa051522.27835497
8Legionellosis_Homo sapiens_hsa051342.24864921
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09028367
10Rheumatoid arthritis_Homo sapiens_hsa053232.02545813
11Type I diabetes mellitus_Homo sapiens_hsa049401.98736310
12Allograft rejection_Homo sapiens_hsa053301.97770433
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.95541739
14Malaria_Homo sapiens_hsa051441.92219826
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.91182870
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86677929
17Asthma_Homo sapiens_hsa053101.86035742
18Hematopoietic cell lineage_Homo sapiens_hsa046401.74569888
19Autoimmune thyroid disease_Homo sapiens_hsa053201.70736090
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67699354
21TNF signaling pathway_Homo sapiens_hsa046681.60765542
22Chemokine signaling pathway_Homo sapiens_hsa040621.53059972
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50091856
24B cell receptor signaling pathway_Homo sapiens_hsa046621.47957803
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47043057
26Primary immunodeficiency_Homo sapiens_hsa053401.45331929
27Pertussis_Homo sapiens_hsa051331.42139219
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37389783
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35774434
30Measles_Homo sapiens_hsa051621.33282253
31African trypanosomiasis_Homo sapiens_hsa051431.32075901
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30957759
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.30146211
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29831286
35Influenza A_Homo sapiens_hsa051641.26253255
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18702655
37Nitrogen metabolism_Homo sapiens_hsa009101.18597543
38T cell receptor signaling pathway_Homo sapiens_hsa046601.17493421
39Toxoplasmosis_Homo sapiens_hsa051451.16442428
40* Phagosome_Homo sapiens_hsa041451.12391170
41Antigen processing and presentation_Homo sapiens_hsa046121.11681218
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10910538
43Lysosome_Homo sapiens_hsa041421.06583292
44Linoleic acid metabolism_Homo sapiens_hsa005911.06359272
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06100698
46Phototransduction_Homo sapiens_hsa047441.04480932
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04219117
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03670231
49Dorso-ventral axis formation_Homo sapiens_hsa043201.02021484
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01537045
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00787077
52Ether lipid metabolism_Homo sapiens_hsa005650.96673162
53Salmonella infection_Homo sapiens_hsa051320.96125030
54Regulation of autophagy_Homo sapiens_hsa041400.91444768
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87711314
56Collecting duct acid secretion_Homo sapiens_hsa049660.85655392
57Herpes simplex infection_Homo sapiens_hsa051680.81412834
58Platelet activation_Homo sapiens_hsa046110.80126237
59Hepatitis B_Homo sapiens_hsa051610.73559393
60Arachidonic acid metabolism_Homo sapiens_hsa005900.73422865
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72626528
62Morphine addiction_Homo sapiens_hsa050320.71537591
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71107647
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69451282
65Type II diabetes mellitus_Homo sapiens_hsa049300.68484763
66Caffeine metabolism_Homo sapiens_hsa002320.67428837
67Acute myeloid leukemia_Homo sapiens_hsa052210.62218264
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57999799
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57767894
70Other glycan degradation_Homo sapiens_hsa005110.57257608
71Hepatitis C_Homo sapiens_hsa051600.55899744
72Olfactory transduction_Homo sapiens_hsa047400.55694656
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53096788
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.52400236
75Tryptophan metabolism_Homo sapiens_hsa003800.51359495
76Viral myocarditis_Homo sapiens_hsa054160.50693022
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49258078
78Mineral absorption_Homo sapiens_hsa049780.47974812
79Prolactin signaling pathway_Homo sapiens_hsa049170.47811353
80Ovarian steroidogenesis_Homo sapiens_hsa049130.46944396
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46735460
82FoxO signaling pathway_Homo sapiens_hsa040680.45969008
83Shigellosis_Homo sapiens_hsa051310.45486092
84MAPK signaling pathway_Homo sapiens_hsa040100.44672150
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.44629026
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44229020
87Serotonergic synapse_Homo sapiens_hsa047260.40547294
88Amoebiasis_Homo sapiens_hsa051460.40266283
89Apoptosis_Homo sapiens_hsa042100.38786433
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.38136781
91ABC transporters_Homo sapiens_hsa020100.36020548
92VEGF signaling pathway_Homo sapiens_hsa043700.31602987
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.31033725
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.31009513
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29593607
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.29584723
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.29407999
98cAMP signaling pathway_Homo sapiens_hsa040240.28783721
99Selenocompound metabolism_Homo sapiens_hsa004500.27100602
100Long-term depression_Homo sapiens_hsa047300.25754878

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