FCER1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.28377620
2modulation by symbiont of host immune response (GO:0052553)6.25072341
3positive regulation by symbiont of host defense response (GO:0052509)6.25072341
4modulation by symbiont of host defense response (GO:0052031)6.25072341
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.25072341
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.25072341
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.25072341
8response to peptidoglycan (GO:0032494)5.53205108
9* neutrophil activation involved in immune response (GO:0002283)5.50879740
10respiratory burst (GO:0045730)5.28126124
11macrophage activation involved in immune response (GO:0002281)4.85172621
12positive regulation of interferon-alpha production (GO:0032727)4.69601221
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66167322
14negative regulation of cell killing (GO:0031342)4.66167322
15regulation of interferon-beta biosynthetic process (GO:0045357)4.64010061
16hydrogen peroxide biosynthetic process (GO:0050665)4.50736238
17regulation of interferon-alpha production (GO:0032647)4.47576817
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.45022831
19production of molecular mediator involved in inflammatory response (GO:0002532)4.40550030
20response to host immune response (GO:0052572)4.28444938
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.28444938
22lipopolysaccharide-mediated signaling pathway (GO:0031663)4.28215916
23reactive oxygen species biosynthetic process (GO:1903409)4.19682348
24* granulocyte activation (GO:0036230)4.17195400
25superoxide anion generation (GO:0042554)4.13907034
26detection of other organism (GO:0098543)3.98759878
27microglial cell activation (GO:0001774)3.92923037
28* neutrophil activation (GO:0042119)3.89651691
29* immunoglobulin mediated immune response (GO:0016064)3.87915668
30response to host (GO:0075136)3.79108321
31response to host defenses (GO:0052200)3.79108321
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.79108321
33regulation of mononuclear cell migration (GO:0071675)3.78727438
34positive regulation of chemokine biosynthetic process (GO:0045080)3.77220247
35detection of bacterium (GO:0016045)3.77025904
36* myeloid cell activation involved in immune response (GO:0002275)3.76770643
37eosinophil chemotaxis (GO:0048245)3.75851958
38leukocyte aggregation (GO:0070486)3.73580246
39detection of external biotic stimulus (GO:0098581)3.71566421
40macrophage activation (GO:0042116)3.68713596
41regulation of B cell receptor signaling pathway (GO:0050855)3.67108315
42antigen processing and presentation of endogenous antigen (GO:0019883)3.65409004
43positive regulation of antigen processing and presentation (GO:0002579)3.58526902
44lymphocyte chemotaxis (GO:0048247)3.56300960
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51537587
46defense response to protozoan (GO:0042832)3.51159539
47cellular extravasation (GO:0045123)3.50701975
48eosinophil migration (GO:0072677)3.46604225
49positive regulation of monocyte chemotaxis (GO:0090026)3.45696591
50positive regulation of type 2 immune response (GO:0002830)3.45463549
51response to muramyl dipeptide (GO:0032495)3.43127854
52positive regulation of cellular amide metabolic process (GO:0034250)3.43080812
53cellular response to type I interferon (GO:0071357)3.39859775
54type I interferon signaling pathway (GO:0060337)3.39859775
55natural killer cell mediated immunity (GO:0002228)3.39680960
56natural killer cell mediated cytotoxicity (GO:0042267)3.39680960
57positive regulation of interferon-beta production (GO:0032728)3.38871033
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38476291
59leukocyte mediated cytotoxicity (GO:0001909)3.38473534
60positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.36826219
61regulation of T cell tolerance induction (GO:0002664)3.36614811
62T-helper 1 type immune response (GO:0042088)3.36286778
63response to type I interferon (GO:0034340)3.34963120
64* B cell mediated immunity (GO:0019724)3.34328937
65detection of biotic stimulus (GO:0009595)3.33925366
66regulation of interleukin-8 biosynthetic process (GO:0045414)3.33689121
67monocyte chemotaxis (GO:0002548)3.33414723
68positive regulation of lymphocyte migration (GO:2000403)3.32442345
69* regulation of mast cell activation involved in immune response (GO:0033006)3.30567246
70regulation of T-helper 2 cell differentiation (GO:0045628)3.30484830
71interferon-gamma-mediated signaling pathway (GO:0060333)3.30068538
72regulation of gamma-delta T cell activation (GO:0046643)3.29304957
73cellular response to thyroid hormone stimulus (GO:0097067)3.28816329
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28370822
75myeloid dendritic cell differentiation (GO:0043011)3.27141564
76regulation of chemokine biosynthetic process (GO:0045073)3.26904002
77regulation of tolerance induction (GO:0002643)3.25781615
78neutrophil mediated immunity (GO:0002446)3.22233565
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21104148
80myeloid dendritic cell activation (GO:0001773)3.20108412
81positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.20019477
82T cell migration (GO:0072678)3.19205342
83* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18938312
84cellular response to zinc ion (GO:0071294)3.17002500
85response to protozoan (GO:0001562)3.15971122
86negative regulation of interleukin-17 production (GO:0032700)3.15504902
87negative regulation of cytokine production involved in immune response (GO:0002719)3.15378635
88detection of molecule of bacterial origin (GO:0032490)3.13091527
89response to interferon-alpha (GO:0035455)3.12118509
90regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.11945137
91regulation of antigen processing and presentation (GO:0002577)3.10823294
92Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10405967
93* myeloid leukocyte activation (GO:0002274)3.09396608
94regulation of T-helper 1 cell differentiation (GO:0045625)3.09328700
95phagosome maturation (GO:0090382)3.08550443
96cellular response to interferon-beta (GO:0035458)3.08108142
97positive regulation of heat generation (GO:0031652)3.07869359
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06461275
99* regulation of leukocyte degranulation (GO:0043300)3.05822689
100negative regulation of mast cell activation (GO:0033004)3.04928581
101* positive regulation of mast cell degranulation (GO:0043306)3.04498554
102* positive regulation of mast cell activation involved in immune response (GO:0033008)3.04498554
103* regulation of mast cell activation (GO:0033003)3.01399665
104response to interferon-beta (GO:0035456)3.00275487
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99454218
106leukocyte degranulation (GO:0043299)2.97907123
107cellular response to interferon-gamma (GO:0071346)2.97697855
108positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.97422813
109* regulation of mast cell degranulation (GO:0043304)2.96101143
110negative regulation of interleukin-12 production (GO:0032695)2.96043331
111regulation of lymphocyte chemotaxis (GO:1901623)2.95643941
112germinal center formation (GO:0002467)2.94497525
113positive regulation of gamma-delta T cell activation (GO:0046645)2.92852785
114regulation of fever generation (GO:0031620)2.92757763
115positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92001024
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.91398656
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91071154
118positive regulation of T cell migration (GO:2000406)2.90195445
119glycosphingolipid catabolic process (GO:0046479)2.90035539
120leukocyte migration involved in inflammatory response (GO:0002523)2.89474703
121response to interferon-gamma (GO:0034341)2.88959739
122negative regulation of viral genome replication (GO:0045071)2.87473627
123positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87336826
124pinocytosis (GO:0006907)2.87129079
125negative regulation of T cell mediated immunity (GO:0002710)2.86007354
126negative regulation of lymphocyte mediated immunity (GO:0002707)2.85499790
127antigen processing and presentation via MHC class Ib (GO:0002475)2.84515231
128regulation of type 2 immune response (GO:0002828)2.84230956
129positive regulation of chemokine production (GO:0032722)2.83678004
130regulation of interferon-gamma biosynthetic process (GO:0045072)2.83519579
131regulation of lymphocyte migration (GO:2000401)2.82883120
132regulation of interleukin-12 production (GO:0032655)2.82613533
133regulation of monocyte chemotaxis (GO:0090025)2.82465726
134amino sugar catabolic process (GO:0046348)2.80856980
135* positive regulation of mast cell activation (GO:0033005)2.80566359
136* positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.80059601
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.79730760
138positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78004073
139negative regulation of leukocyte mediated immunity (GO:0002704)2.76325703
140positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75591849
141regulation of interleukin-17 production (GO:0032660)2.74008569
142* positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.73147675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.43218669
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.35455040
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.66703427
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.66196721
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.34751123
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.09856467
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90624400
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.62926452
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59091372
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.58387412
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36922169
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.30673770
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97330852
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92644581
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82359561
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78456483
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.75894441
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66761440
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66306141
20* SPI1_23547873_ChIP-Seq_NB4_Human2.43654175
21* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.31118690
22* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05885370
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.93742099
24* RUNX1_22412390_ChIP-Seq_EML_Mouse1.83382648
25* PU_27001747_Chip-Seq_BMDM_Mouse1.83249302
26CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82988325
27SCL_19346495_ChIP-Seq_HPC-7_Human1.82034988
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77796993
29* VDR_24763502_ChIP-Seq_THP-1_Human1.77324274
30MYB_26560356_Chip-Seq_TH2_Human1.76972983
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74509286
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70493950
33SPI1_23127762_ChIP-Seq_K562_Human1.70198481
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68538840
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67698260
36RUNX_20019798_ChIP-Seq_JUKART_Human1.64999670
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64968168
38VDR_24787735_ChIP-Seq_THP-1_Human1.63626684
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62049901
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54654878
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54296194
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53063892
43CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50031817
44* MAF_26560356_Chip-Seq_TH1_Human1.49014126
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45262221
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44724053
47MYB_26560356_Chip-Seq_TH1_Human1.35909749
48VDR_21846776_ChIP-Seq_THP-1_Human1.35344489
49* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31930942
50SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30107504
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30088010
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26540972
53GATA1_19941826_ChIP-Seq_K562_Human1.25322050
54* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23218749
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22078943
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20017081
57GATA3_26560356_Chip-Seq_TH2_Human1.19497306
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16981758
59GATA3_27048872_Chip-Seq_THYMUS_Human1.16692822
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14511230
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12571110
62STAT1_20625510_ChIP-Seq_HELA_Human1.11323382
63UTX_26944678_Chip-Seq_JUKART_Human1.08595310
64LXR_22292898_ChIP-Seq_THP-1_Human1.05525604
65BCL6_27268052_Chip-Seq_Bcells_Human1.02240760
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01947860
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01692541
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.01586653
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99344613
70STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99056848
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98029797
72MYC_22102868_ChIP-Seq_BL_Human0.96858613
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96319048
74KDM2B_26808549_Chip-Seq_DND41_Human0.96027451
75EGR1_19032775_ChIP-ChIP_M12_Human0.91651546
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91325215
77GATA1_22025678_ChIP-Seq_K562_Human0.91176529
78BCOR_27268052_Chip-Seq_Bcells_Human0.89232004
79TFEB_21752829_ChIP-Seq_HELA_Human0.88604101
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83860808
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83615742
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83546484
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82808052
84SPI1_20517297_ChIP-Seq_HL60_Human0.82470323
85TCF7_22412390_ChIP-Seq_EML_Mouse0.81991112
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79755040
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.77014330
88GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76924941
89MAF_26560356_Chip-Seq_TH2_Human0.76515272
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.76120803
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.74872412
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.73404523
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72429233
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72274300
95* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72030635
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71900871
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71483392
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71360706
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70585856
100SMRT_27268052_Chip-Seq_Bcells_Human0.70417403
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70004999
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69147537
103SOX2_20726797_ChIP-Seq_SW620_Human0.66586122
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65857131
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65683855
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65683855
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65615342
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62321890
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62127360
110GATA2_19941826_ChIP-Seq_K562_Human0.61353684
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59543378
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59491250
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.58724781
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.57197120
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.56842305
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55967785
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.55674860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.40375796
2MP0003436_decreased_susceptibility_to4.39582018
3MP0009785_altered_susceptibility_to3.91288961
4* MP0002148_abnormal_hypersensitivity_rea3.84945056
5MP0006082_CNS_inflammation3.70009634
6MP0003303_peritoneal_inflammation3.51980338
7* MP0002419_abnormal_innate_immunity3.48209056
8* MP0005000_abnormal_immune_tolerance3.31403179
9MP0005058_abnormal_lysosome_morphology3.17622994
10* MP0005025_abnormal_response_to3.14681940
11MP0003724_increased_susceptibility_to3.09617371
12MP0005671_abnormal_response_to2.80442282
13MP0001790_abnormal_immune_system2.73748727
14MP0005387_immune_system_phenotype2.73748727
15* MP0002452_abnormal_antigen_presenting2.71005243
16* MP0002723_abnormal_immune_serum2.56660280
17MP0000685_abnormal_immune_system2.50028949
18* MP0001800_abnormal_humoral_immune2.45838097
19* MP0001819_abnormal_immune_cell2.33738560
20MP0001533_abnormal_skeleton_physiology2.33318255
21MP0004510_myositis2.33318154
22* MP0002420_abnormal_adaptive_immunity2.30698918
23MP0002405_respiratory_system_inflammati2.09701459
24MP0001853_heart_inflammation2.08109306
25MP0003172_abnormal_lysosome_physiology2.05156428
26* MP0005464_abnormal_platelet_physiology2.00791654
27* MP0001845_abnormal_inflammatory_respons1.94892206
28MP0003448_altered_tumor_morphology1.79484559
29MP0003075_altered_response_to1.79478416
30MP0008469_abnormal_protein_level1.77189098
31MP0003191_abnormal_cellular_cholesterol1.76104624
32MP0004947_skin_inflammation1.74504035
33MP0002006_tumorigenesis1.70381846
34MP0005310_abnormal_salivary_gland1.67936897
35* MP0009764_decreased_sensitivity_to1.67734910
36MP0010155_abnormal_intestine_physiology1.67403380
37MP0009840_abnormal_foam_cell1.67320811
38* MP0000343_altered_response_to1.64270193
39* MP0000716_abnormal_immune_system1.63177671
40MP0009333_abnormal_splenocyte_physiolog1.59849049
41MP0003806_abnormal_nucleotide_metabolis1.57928369
42MP0008004_abnormal_stomach_pH1.57314384
43MP0000858_altered_metastatic_potential1.53710538
44* MP0002398_abnormal_bone_marrow1.49344458
45MP0009278_abnormal_bone_marrow1.47849907
46* MP0002998_abnormal_bone_remodeling1.39971109
47MP0005166_decreased_susceptibility_to1.39747475
48MP0000689_abnormal_spleen_morphology1.33263535
49MP0003690_abnormal_glial_cell1.32361844
50MP0002166_altered_tumor_susceptibility1.31204858
51* MP0002429_abnormal_blood_cell1.30410546
52MP0003300_gastrointestinal_ulcer1.29375861
53MP0000604_amyloidosis1.28083304
54MP0005167_abnormal_blood-brain_barrier1.27467223
55MP0001545_abnormal_hematopoietic_system1.27126222
56MP0005397_hematopoietic_system_phenotyp1.27126222
57MP0002277_abnormal_respiratory_mucosa1.23977434
58MP0002139_abnormal_hepatobiliary_system1.22794640
59MP0002722_abnormal_immune_system1.20749504
60MP0004782_abnormal_surfactant_physiolog1.20395813
61MP0003186_abnormal_redox_activity1.20265925
62MP0003183_abnormal_peptide_metabolism1.17493191
63MP0005164_abnormal_response_to1.16365904
64MP0001851_eye_inflammation1.12378690
65MP0003828_pulmonary_edema1.11196857
66MP0005390_skeleton_phenotype1.10146130
67MP0005174_abnormal_tail_pigmentation1.07712319
68MP0002933_joint_inflammation1.02291884
69MP0009763_increased_sensitivity_to1.01069917
70MP0000569_abnormal_digit_pigmentation0.98978129
71MP0010307_abnormal_tumor_latency0.96545965
72MP0006054_spinal_hemorrhage0.96279284
73MP0000465_gastrointestinal_hemorrhage0.90274975
74MP0000249_abnormal_blood_vessel0.83900788
75MP0004883_abnormal_blood_vessel0.83843312
76MP0005076_abnormal_cell_differentiation0.83104648
77MP0000490_abnormal_crypts_of0.82615267
78MP0003195_calcinosis0.81564102
79MP0009765_abnormal_xenobiotic_induced0.79193937
80MP0003763_abnormal_thymus_physiology0.78589991
81MP0003656_abnormal_erythrocyte_physiolo0.71816894
82MP0002332_abnormal_exercise_endurance0.71204339
83MP0008260_abnormal_autophagy0.70345740
84MP0000371_diluted_coat_color0.70284977
85MP0002132_abnormal_respiratory_system0.70118223
86MP0001542_abnormal_bone_strength0.69043002
87MP0000015_abnormal_ear_pigmentation0.68124120
88MP0008874_decreased_physiological_sensi0.68009798
89MP0005365_abnormal_bile_salt0.67427596
90* MP0003795_abnormal_bone_structure0.67315669
91MP0000920_abnormal_myelination0.65745189
92MP0001663_abnormal_digestive_system0.65359162
93MP0001873_stomach_inflammation0.65125375
94MP0002138_abnormal_hepatobiliary_system0.64718013
95MP0003866_abnormal_defecation0.62887210
96MP0002136_abnormal_kidney_physiology0.62879722
97MP0003566_abnormal_cell_adhesion0.61518866
98MP0003453_abnormal_keratinocyte_physiol0.60969829
99MP0008873_increased_physiological_sensi0.59919475
100MP0004808_abnormal_hematopoietic_stem0.58918950
101MP0005257_abnormal_intraocular_pressure0.56562417
102MP0002254_reproductive_system_inflammat0.56234600
103MP0000703_abnormal_thymus_morphology0.54536027
104MP0005165_increased_susceptibility_to0.54348342
105MP0002090_abnormal_vision0.52514389
106MP0003329_amyloid_beta_deposits0.51990400
107MP0005647_abnormal_sex_gland0.51288153
108MP0005584_abnormal_enzyme/coenzyme_acti0.50372190
109MP0005381_digestive/alimentary_phenotyp0.49021512
110MP0002396_abnormal_hematopoietic_system0.48824192
111MP0003091_abnormal_cell_migration0.48494984
112MP0005319_abnormal_enzyme/_coenzyme0.47892574
113MP0005451_abnormal_body_composition0.47642301
114MP0000767_abnormal_smooth_muscle0.45904864
115MP0000609_abnormal_liver_physiology0.45768900

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.97157782
2Eczematoid dermatitis (HP:0000976)7.46820232
3Recurrent bacterial skin infections (HP:0005406)7.22185441
4Recurrent gram-negative bacterial infections (HP:0005420)6.58978139
5Abnormality of macrophages (HP:0004311)5.53074603
6Mediastinal lymphadenopathy (HP:0100721)5.19862627
7Systemic lupus erythematosus (HP:0002725)5.14232275
8Vacuolated lymphocytes (HP:0001922)4.79324740
9Obstructive lung disease (HP:0006536)4.46544659
10Chronic obstructive pulmonary disease (HP:0006510)4.46544659
11Increased cerebral lipofuscin (HP:0011813)4.46205019
12Gingivitis (HP:0000230)4.39172416
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.36477956
14Recurrent skin infections (HP:0001581)4.35745012
15Stomatitis (HP:0010280)4.34670228
16Elevated erythrocyte sedimentation rate (HP:0003565)4.29959482
17Myositis (HP:0100614)4.23094048
18Disinhibition (HP:0000734)4.05087612
19Axonal loss (HP:0003447)4.02114337
20Orchitis (HP:0100796)3.99391659
21Autoimmune thrombocytopenia (HP:0001973)3.89274448
22Recurrent fungal infections (HP:0002841)3.81390386
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.78963358
24Retrobulbar optic neuritis (HP:0100654)3.75663526
25Optic neuritis (HP:0100653)3.75663526
26Glomerulonephritis (HP:0000099)3.70214768
27Abnormality of glycolipid metabolism (HP:0010969)3.47899027
28Abnormality of liposaccharide metabolism (HP:0010968)3.47899027
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.47899027
30Basal ganglia calcification (HP:0002135)3.36973720
31Agnosia (HP:0010524)3.32520959
32Dysostosis multiplex (HP:0000943)3.22716616
33Vasculitis (HP:0002633)3.21077764
34Prolonged bleeding time (HP:0003010)3.16217233
35Urticaria (HP:0001025)3.14638771
36Amyloidosis (HP:0011034)3.12034834
37Cellulitis (HP:0100658)3.08158750
38Mutism (HP:0002300)3.06073707
39Recurrent viral infections (HP:0004429)2.99741019
40Periodontitis (HP:0000704)2.93392314
41Meningitis (HP:0001287)2.91187979
42Pustule (HP:0200039)2.86866000
43Interstitial pulmonary disease (HP:0006530)2.86838822
44Recurrent cutaneous fungal infections (HP:0011370)2.83660217
45Chronic mucocutaneous candidiasis (HP:0002728)2.83660217
46Prostate neoplasm (HP:0100787)2.79234011
47Recurrent pneumonia (HP:0006532)2.75039665
48Increased serum ferritin (HP:0003281)2.74752212
49Petechiae (HP:0000967)2.73315746
50Encephalitis (HP:0002383)2.71810135
51Thick nail (HP:0001805)2.70821761
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69800160
53Pulmonary infiltrates (HP:0002113)2.65627014
54Mucopolysacchariduria (HP:0008155)2.58817272
55Urinary glycosaminoglycan excretion (HP:0003541)2.58817272
56Increased IgM level (HP:0003496)2.58753674
57T lymphocytopenia (HP:0005403)2.54135404
58Hepatosplenomegaly (HP:0001433)2.50294277
59Osteomyelitis (HP:0002754)2.46730424
60Nephritis (HP:0000123)2.45932878
61Abnormality of iron homeostasis (HP:0011031)2.41658569
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41441820
63Abnormality of polysaccharide metabolism (HP:0011012)2.41441820
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41441820
65Chest pain (HP:0100749)2.41302400
66Spontaneous hematomas (HP:0007420)2.40929281
67Gangrene (HP:0100758)2.37726022
68Leukocytosis (HP:0001974)2.37006305
69Pulmonary embolism (HP:0002204)2.36304631
70Upper motor neuron abnormality (HP:0002127)2.34631854
71Recurrent lower respiratory tract infections (HP:0002783)2.33337302
72Poor head control (HP:0002421)2.29860433
73Hemoptysis (HP:0002105)2.28605670
74Polyneuropathy (HP:0001271)2.28515296
75Arterial thrombosis (HP:0004420)2.24173807
76Keratoconjunctivitis sicca (HP:0001097)2.24077464
77Abnormality of complement system (HP:0005339)2.20530579
78Episodic fever (HP:0001954)2.20175942
79Pathologic fracture (HP:0002756)2.20047841
80Premature loss of primary teeth (HP:0006323)2.17742632
81Hypergammaglobulinemia (HP:0010702)2.17499752
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.17086932
83Tetraparesis (HP:0002273)2.14975580
84Vertigo (HP:0002321)2.12668378
85Gingival bleeding (HP:0000225)2.12418010
86Chronic otitis media (HP:0000389)2.12299560
87Bone pain (HP:0002653)2.11658372
88Increased IgE level (HP:0003212)2.10979879
89Myocardial infarction (HP:0001658)2.10889798
90Progressive neurologic deterioration (HP:0002344)2.10141500
91Joint hemorrhage (HP:0005261)2.07364600
92Osteolytic defects of the hand bones (HP:0009699)2.06520194
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.06520194
94Neurofibrillary tangles (HP:0002185)2.06365628
95Sepsis (HP:0100806)2.04683178
96Purpura (HP:0000979)2.04556815
97Keratoconjunctivitis (HP:0001096)2.03239814
98Abnormality of the prostate (HP:0008775)2.03223896
99Inappropriate behavior (HP:0000719)2.02972184
100Loss of speech (HP:0002371)2.01287890
101Progressive visual loss (HP:0000529)1.99675206
102Memory impairment (HP:0002354)1.98714897
103Abnormality of transition element cation homeostasis (HP:0011030)1.97664978
104Neuronal loss in central nervous system (HP:0002529)1.97166892
105Glomerulopathy (HP:0100820)1.95952440
106Complement deficiency (HP:0004431)1.95677400
107Inflammation of the large intestine (HP:0002037)1.93549929
108Anorexia (HP:0002039)1.92896036
109Gastrointestinal infarctions (HP:0005244)1.92842266
110Abnormality of the pleura (HP:0002103)1.90385132
111Joint swelling (HP:0001386)1.88799289
112Conjunctival telangiectasia (HP:0000524)1.88796231
113Diminished motivation (HP:0000745)1.88638901
114Autoimmune hemolytic anemia (HP:0001890)1.88207551
115Nausea (HP:0002018)1.87203585
116Hematochezia (HP:0002573)1.86726916
117Arthralgia (HP:0002829)1.86559501
118Abnormality of T cell number (HP:0011839)1.84233064
119Eosinophilia (HP:0001880)1.84223542
120Abnormality of the pericardium (HP:0001697)1.84100995
121Apathy (HP:0000741)1.82453503
122Skin ulcer (HP:0200042)1.82412337
123Thyroiditis (HP:0100646)1.81123874
124Epistaxis (HP:0000421)1.80137996
125Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78827781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.70233436
2RIPK44.55797557
3MAP3K144.04691151
4IRAK43.68304630
5TBK13.29908608
6PBK3.28892333
7IRAK32.93526776
8TYK22.88939322
9MAP4K12.52266602
10TXK2.46136504
11KIT2.43725137
12IKBKE2.43319839
13IKBKB2.26059251
14ERN12.15622300
15PIM22.00210156
16JAK31.94998355
17JAK11.74902397
18NME21.74255918
19CSK1.67315787
20SYK1.60747855
21ZAP701.59558293
22NEK91.59255489
23TAOK11.55403097
24TNK21.49984461
25BTK1.47407240
26TGFBR21.45678350
27HCK1.40878876
28TEC1.37557719
29ABL21.31056053
30PRPF4B1.27431725
31CSF1R1.27404188
32GRK71.27257239
33* LYN1.26177906
34TAOK31.24458854
35CHUK1.22212423
36PIM11.21482090
37BMPR21.20961259
38MAP3K131.20228633
39FES1.14324253
40FGR1.13244679
41MATK1.13070491
42LCK1.12925749
43CLK11.11903897
44BMX1.09355846
45TESK21.07104480
46JAK21.03770146
47RPS6KA41.02982082
48ACVR1B1.01525014
49STK100.95429586
50DDR20.95025849
51EIF2AK20.93411468
52MST40.91143814
53CDC42BPA0.90877173
54YES10.89715524
55STK40.89111577
56TRPM70.86896838
57EPHB10.85493725
58MAP2K30.85264537
59PRKCD0.81575324
60MARK30.75613724
61RIPK10.73383032
62MST1R0.71531239
63MAP3K120.71452049
64CDK190.71395538
65ABL10.68905783
66ERBB30.67714885
67ARAF0.67091279
68ITK0.66714508
69ADRBK20.62691574
70KDR0.61549264
71EGFR0.60928257
72MAP3K50.60163255
73MAP3K110.58921247
74DAPK20.56456838
75IRAK20.54778576
76MAPK70.49693388
77MAPK120.49489532
78FGFR30.49380401
79MOS0.48671439
80EIF2AK30.46957518
81MAP2K60.46286687
82LRRK20.45195632
83TESK10.44993419
84KSR20.43693319
85RPS6KA60.42411250
86IRAK10.41873571
87MARK20.41408511
88MAPKAPK20.40573992
89CDK60.39827685
90SIK30.39596069
91PRKCQ0.39107055
92FYN0.38775478
93GRK60.38577109
94CAMKK20.38545863
95SCYL20.37390815
96MAP3K30.33347704
97PAK40.32047485
98CAMK1D0.32046620
99PIK3CG0.31377818
100MAP3K10.31075741
101PTK2B0.30115619
102STK240.29810675
103RPS6KL10.29232192
104RPS6KC10.29232192
105SIK20.28828451
106IGF1R0.28349290
107MAP3K60.27987659
108EPHA30.26466266
109STK30.26447786
110BMPR1B0.25591813
111TAOK20.25508771
112MAP3K100.25439935
113DAPK30.23724189
114INSR0.22882770
115PDK10.22843086
116PRKD20.22246239
117RPS6KA20.21817365
118MAPK40.21798740
119CDK40.21730991
120HIPK20.21507989
121PDPK10.20488198
122PRKG20.20378030
123TLK10.19980143

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.68333305
2Leishmaniasis_Homo sapiens_hsa051403.53532342
3Graft-versus-host disease_Homo sapiens_hsa053323.39411127
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.83466952
5Legionellosis_Homo sapiens_hsa051342.61237901
6Osteoclast differentiation_Homo sapiens_hsa043802.53493641
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50579490
8Pertussis_Homo sapiens_hsa051332.47304606
9Lysosome_Homo sapiens_hsa041422.46102989
10Allograft rejection_Homo sapiens_hsa053302.43060013
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.36931208
12Rheumatoid arthritis_Homo sapiens_hsa053232.36103598
13Malaria_Homo sapiens_hsa051442.28572067
14* Tuberculosis_Homo sapiens_hsa051522.24858615
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19873262
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11330491
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05678774
18Phagosome_Homo sapiens_hsa041451.99031700
19Other glycan degradation_Homo sapiens_hsa005111.98835283
20Measles_Homo sapiens_hsa051621.98240538
21Salmonella infection_Homo sapiens_hsa051321.95450878
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.93718593
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.78945429
24Type I diabetes mellitus_Homo sapiens_hsa049401.73887195
25Influenza A_Homo sapiens_hsa051641.65958700
26TNF signaling pathway_Homo sapiens_hsa046681.65667769
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63555789
28Antigen processing and presentation_Homo sapiens_hsa046121.61694347
29Hematopoietic cell lineage_Homo sapiens_hsa046401.60358439
30* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55435518
31B cell receptor signaling pathway_Homo sapiens_hsa046621.50605283
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46883584
33African trypanosomiasis_Homo sapiens_hsa051431.44313097
34Toxoplasmosis_Homo sapiens_hsa051451.44263874
35Chemokine signaling pathway_Homo sapiens_hsa040621.41790723
36Herpes simplex infection_Homo sapiens_hsa051681.39994293
37Shigellosis_Homo sapiens_hsa051311.35000272
38Apoptosis_Homo sapiens_hsa042101.33574502
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30189033
40* Asthma_Homo sapiens_hsa053101.24054760
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.14843526
42Autoimmune thyroid disease_Homo sapiens_hsa053201.05250585
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02755848
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02356253
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01583031
46Primary immunodeficiency_Homo sapiens_hsa053400.99677350
47Hepatitis B_Homo sapiens_hsa051610.99398403
48Viral myocarditis_Homo sapiens_hsa054160.98915648
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.93462910
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90367937
51Collecting duct acid secretion_Homo sapiens_hsa049660.88696005
52Complement and coagulation cascades_Homo sapiens_hsa046100.88537696
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86029379
54Amoebiasis_Homo sapiens_hsa051460.84962592
55Prion diseases_Homo sapiens_hsa050200.84632251
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83581103
57Hepatitis C_Homo sapiens_hsa051600.80813798
58* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75707056
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75633307
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66610133
61T cell receptor signaling pathway_Homo sapiens_hsa046600.66028316
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64767371
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62434284
64Acute myeloid leukemia_Homo sapiens_hsa052210.55727567
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52232182
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52231083
67Sphingolipid metabolism_Homo sapiens_hsa006000.48757514
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.48569111
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48462511
70Pancreatic cancer_Homo sapiens_hsa052120.47909536
71Bladder cancer_Homo sapiens_hsa052190.47788895
72Epstein-Barr virus infection_Homo sapiens_hsa051690.47583401
73* Platelet activation_Homo sapiens_hsa046110.45931372
74Chronic myeloid leukemia_Homo sapiens_hsa052200.45291517
75Mineral absorption_Homo sapiens_hsa049780.45216245
76Renin-angiotensin system_Homo sapiens_hsa046140.43989119
77Caffeine metabolism_Homo sapiens_hsa002320.39785416
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38873182
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38211650
80HIF-1 signaling pathway_Homo sapiens_hsa040660.33730681
81Vibrio cholerae infection_Homo sapiens_hsa051100.32984439
82Endocytosis_Homo sapiens_hsa041440.32744981
83* Sphingolipid signaling pathway_Homo sapiens_hsa040710.31142564
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.29264939
85Viral carcinogenesis_Homo sapiens_hsa052030.28997162
86Prolactin signaling pathway_Homo sapiens_hsa049170.28547224
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26310675
88Proteasome_Homo sapiens_hsa030500.25747987
89Galactose metabolism_Homo sapiens_hsa000520.24296519
90Non-small cell lung cancer_Homo sapiens_hsa052230.20748178
91* Phospholipase D signaling pathway_Homo sapiens_hsa040720.19962558
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19458145
93Renal cell carcinoma_Homo sapiens_hsa052110.18952614
94VEGF signaling pathway_Homo sapiens_hsa043700.18813556
95HTLV-I infection_Homo sapiens_hsa051660.18419381
96PPAR signaling pathway_Homo sapiens_hsa033200.18281009
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17465898
98Steroid biosynthesis_Homo sapiens_hsa001000.16644252
99Notch signaling pathway_Homo sapiens_hsa043300.16015242
100GnRH signaling pathway_Homo sapiens_hsa049120.15370072
101Sulfur metabolism_Homo sapiens_hsa009200.14342218
102Small cell lung cancer_Homo sapiens_hsa052220.14287662
103Type II diabetes mellitus_Homo sapiens_hsa049300.14017515
104Arachidonic acid metabolism_Homo sapiens_hsa005900.14002156
105Proteoglycans in cancer_Homo sapiens_hsa052050.13159500
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12945825
107MAPK signaling pathway_Homo sapiens_hsa040100.11403075
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10870968
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09604450
110Pentose phosphate pathway_Homo sapiens_hsa000300.08733023
111Systemic lupus erythematosus_Homo sapiens_hsa053220.08474594
112FoxO signaling pathway_Homo sapiens_hsa040680.07123863
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06305779

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