FCER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.63129457
2regulation of B cell receptor signaling pathway (GO:0050855)6.56431542
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.75136620
4immunoglobulin mediated immune response (GO:0016064)5.63499769
5positive regulation of gamma-delta T cell activation (GO:0046645)5.38374585
6antigen processing and presentation of endogenous antigen (GO:0019883)5.35415350
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.27929427
8positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.16155238
9B cell homeostasis (GO:0001782)5.06177412
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93989883
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92642057
12T-helper 1 type immune response (GO:0042088)4.78990689
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77520618
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.77520618
15modulation by symbiont of host immune response (GO:0052553)4.77520618
16positive regulation by symbiont of host defense response (GO:0052509)4.77520618
17modulation by symbiont of host defense response (GO:0052031)4.77520618
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77520618
19B cell mediated immunity (GO:0019724)4.71592342
20interferon-gamma-mediated signaling pathway (GO:0060333)4.70088285
21B cell proliferation (GO:0042100)4.56213451
22NIK/NF-kappaB signaling (GO:0038061)4.54938741
23regulation of interferon-gamma biosynthetic process (GO:0045072)4.42861701
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.38787037
25negative thymic T cell selection (GO:0045060)4.36346339
26positive regulation of B cell differentiation (GO:0045579)4.34273468
27type I interferon signaling pathway (GO:0060337)4.26939464
28cellular response to type I interferon (GO:0071357)4.26939464
29response to type I interferon (GO:0034340)4.24856675
30T cell lineage commitment (GO:0002360)4.22396985
31detection of bacterium (GO:0016045)4.19710172
32positive thymic T cell selection (GO:0045059)4.17649130
33regulation of interferon-beta biosynthetic process (GO:0045357)4.15114168
34regulation of antigen processing and presentation (GO:0002577)4.06438709
35defense response to protozoan (GO:0042832)4.06351807
36regulation of B cell differentiation (GO:0045577)4.05301417
37T cell migration (GO:0072678)4.04474633
38response to protozoan (GO:0001562)4.02790683
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02727377
40negative regulation of cell killing (GO:0031342)4.02727377
41T cell costimulation (GO:0031295)4.00573860
42negative T cell selection (GO:0043383)3.96453865
43thymic T cell selection (GO:0045061)3.96260998
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94796754
45lymphocyte costimulation (GO:0031294)3.94782256
46myeloid dendritic cell differentiation (GO:0043011)3.89670618
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.83893853
48detection of other organism (GO:0098543)3.83693963
49positive regulation of interferon-alpha production (GO:0032727)3.77849613
50negative regulation of B cell proliferation (GO:0030889)3.75881772
51regulation of gamma-delta T cell activation (GO:0046643)3.74067274
52regulation of alpha-beta T cell proliferation (GO:0046640)3.73726414
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72700898
54regulation of B cell proliferation (GO:0030888)3.72160348
55myeloid dendritic cell activation (GO:0001773)3.71925660
56cellular response to interferon-gamma (GO:0071346)3.55441999
57regulation of interferon-alpha production (GO:0032647)3.54550497
58regulation of T-helper 1 cell differentiation (GO:0045625)3.53295547
59positive regulation of B cell proliferation (GO:0030890)3.50811405
60antigen receptor-mediated signaling pathway (GO:0050851)3.49361720
61lymphocyte homeostasis (GO:0002260)3.48959676
62positive regulation of macrophage cytokine production (GO:0060907)3.44227440
63cellular response to interleukin-15 (GO:0071350)3.43315017
64response to muramyl dipeptide (GO:0032495)3.37564351
65response to host immune response (GO:0052572)3.36288796
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36288796
67negative regulation of phagocytosis (GO:0050765)3.34361903
68positive regulation of B cell activation (GO:0050871)3.30487205
69macrophage activation involved in immune response (GO:0002281)3.30063310
70positive regulation of alpha-beta T cell proliferation (GO:0046641)3.25947641
71positive regulation of type 2 immune response (GO:0002830)3.24518568
72response to interleukin-15 (GO:0070672)3.24020841
73T cell selection (GO:0045058)3.23047125
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22856033
75adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.17503579
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13661162
77germinal center formation (GO:0002467)3.12634289
78regulation of B cell apoptotic process (GO:0002902)3.11324665
79positive regulation of cytokine biosynthetic process (GO:0042108)3.08888056
80response to host (GO:0075136)3.06928654
81response to host defenses (GO:0052200)3.06928654
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06928654
83regulation of interleukin-2 biosynthetic process (GO:0045076)3.05805308
84regulation of B cell activation (GO:0050864)3.05566391
85positive regulation of antigen processing and presentation (GO:0002579)3.04302935
86positive T cell selection (GO:0043368)3.03933030
87cytidine metabolic process (GO:0046087)3.02216087
88cytidine catabolic process (GO:0006216)3.02216087
89cytidine deamination (GO:0009972)3.02216087
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.01298172
91mature B cell differentiation (GO:0002335)2.99961567
92positive regulation of interleukin-2 production (GO:0032743)2.99627490
93response to interferon-gamma (GO:0034341)2.98428366
94leukocyte homeostasis (GO:0001776)2.96441243
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94820085
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93901722
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93234102
98regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.92361746
99positive regulation of protein homooligomerization (GO:0032464)2.90918611
100positive regulation of interferon-gamma production (GO:0032729)2.89523171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.08157582
2MYC_22102868_ChIP-Seq_BL_Human5.04135368
3SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.80338872
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72720458
5VDR_21846776_ChIP-Seq_THP-1_Human3.36521395
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.23396648
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91811399
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.82675958
9MAF_26560356_Chip-Seq_TH1_Human2.82438851
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81746666
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79091220
12CIITA_25753668_ChIP-Seq_RAJI_Human2.77751621
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.66279160
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59249470
15* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55160543
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.49002141
17* MYB_26560356_Chip-Seq_TH2_Human2.44609231
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41854875
19* MYB_26560356_Chip-Seq_TH1_Human2.34638454
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30486416
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25375703
22VDR_24763502_ChIP-Seq_THP-1_Human2.24387085
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.17247858
24* SPI1_23547873_ChIP-Seq_NB4_Human2.13608012
25UTX_26944678_Chip-Seq_JUKART_Human2.11735234
26MAF_26560356_Chip-Seq_TH2_Human2.02302492
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97451132
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.94257231
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91881022
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91154063
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90742183
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82995770
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82341567
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.81793427
35TCF7_22412390_ChIP-Seq_EML_Mouse1.80125074
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78981603
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77258827
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76997793
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75853601
40RUNX_20019798_ChIP-Seq_JUKART_Human1.72266802
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70352732
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69910450
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68873921
44* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68429384
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68108018
46GATA1_22025678_ChIP-Seq_K562_Human1.67756663
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67562750
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66249916
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.63827677
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63462026
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62251607
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59145665
53E2F7_22180533_ChIP-Seq_HELA_Human1.58485710
54LXR_22292898_ChIP-Seq_THP-1_Human1.51768981
55SCL_19346495_ChIP-Seq_HPC-7_Human1.50325825
56GATA3_27048872_Chip-Seq_THYMUS_Human1.43551417
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41718535
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41640135
59KDM2B_26808549_Chip-Seq_DND41_Human1.41363035
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37719673
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36524720
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35636175
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31857299
64SPI1_23127762_ChIP-Seq_K562_Human1.26736307
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26526296
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22990844
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18588173
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13174325
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.12092411
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.11726346
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11593924
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06289849
73BCL6_27268052_Chip-Seq_Bcells_Human1.05307873
74BCOR_27268052_Chip-Seq_Bcells_Human1.03324889
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03035989
76VDR_23849224_ChIP-Seq_CD4+_Human1.02466974
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01681720
78NCOR1_26117541_ChIP-Seq_K562_Human1.00723296
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00075047
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97983182
81GATA3_26560356_Chip-Seq_TH2_Human0.95999910
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95759929
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95160379
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92912717
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.91645731
86FOXP3_21729870_ChIP-Seq_TREG_Human0.91597735
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.91226489
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90888568
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90887902
90TFEB_21752829_ChIP-Seq_HELA_Human0.90751630
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90059765
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.89886827
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89753094
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89602886
95SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88497142
96PU_27001747_Chip-Seq_BMDM_Mouse0.88090604
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87375315
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86955225
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.86792054
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.86304574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system5.03903364
2MP0005671_abnormal_response_to4.77006029
3MP0001835_abnormal_antigen_presentation4.50713205
4MP0001790_abnormal_immune_system4.41027644
5MP0005387_immune_system_phenotype4.41027644
6MP0001800_abnormal_humoral_immune4.08849874
7MP0003303_peritoneal_inflammation3.46416428
8MP0005000_abnormal_immune_tolerance3.33960388
9MP0002452_abnormal_antigen_presenting3.11823066
10MP0002723_abnormal_immune_serum3.00839327
11MP0005645_abnormal_hypothalamus_physiol2.98997556
12MP0003763_abnormal_thymus_physiology2.96728275
13MP0002138_abnormal_hepatobiliary_system2.90244540
14MP0002420_abnormal_adaptive_immunity2.82459096
15MP0001819_abnormal_immune_cell2.76827661
16MP0002398_abnormal_bone_marrow2.60184441
17MP0003436_decreased_susceptibility_to2.56912069
18MP0005025_abnormal_response_to2.40529234
19MP0002166_altered_tumor_susceptibility2.36068883
20MP0000716_abnormal_immune_system2.35557735
21MP0009785_altered_susceptibility_to2.26119163
22MP0002148_abnormal_hypersensitivity_rea2.09432495
23MP0000689_abnormal_spleen_morphology2.09047995
24MP0002419_abnormal_innate_immunity2.07100760
25MP0005310_abnormal_salivary_gland2.01197658
26MP0003300_gastrointestinal_ulcer1.97598695
27MP0003183_abnormal_peptide_metabolism1.96124240
28MP0002429_abnormal_blood_cell1.95091564
29MP0002722_abnormal_immune_system1.86254630
30MP0001348_abnormal_lacrimal_gland1.81529034
31MP0010155_abnormal_intestine_physiology1.73915318
32MP0001873_stomach_inflammation1.72585792
33MP0009333_abnormal_splenocyte_physiolog1.71065806
34MP0002405_respiratory_system_inflammati1.67607814
35MP0001845_abnormal_inflammatory_respons1.67253727
36MP0002006_tumorigenesis1.64602751
37MP0008057_abnormal_DNA_replication1.60130798
38MP0000703_abnormal_thymus_morphology1.57132572
39MP0004947_skin_inflammation1.49259896
40MP0005451_abnormal_body_composition1.47138121
41MP0002396_abnormal_hematopoietic_system1.41776660
42MP0005464_abnormal_platelet_physiology1.39827004
43MP0001853_heart_inflammation1.21978200
44MP0003724_increased_susceptibility_to1.16264487
45MP0010094_abnormal_chromosome_stability1.13161632
46MP0004510_myositis1.12649161
47MP0003091_abnormal_cell_migration1.10779013
48MP0002019_abnormal_tumor_incidence1.08045137
49MP0008469_abnormal_protein_level1.06462848
50MP0002163_abnormal_gland_morphology1.03419771
51MP0003045_fibrosis1.03339361
52MP0000490_abnormal_crypts_of1.01558777
53MP0003077_abnormal_cell_cycle0.94561958
54MP0003172_abnormal_lysosome_physiology0.92321709
55MP0001727_abnormal_embryo_implantation0.88681627
56MP0004381_abnormal_hair_follicle0.87699620
57MP0005623_abnormal_meninges_morphology0.87652212
58MP0000858_altered_metastatic_potential0.86914597
59MP0005075_abnormal_melanosome_morpholog0.86805252
60MP0002009_preneoplasia0.85299800
61MP0004808_abnormal_hematopoietic_stem0.81849642
62MP0003866_abnormal_defecation0.81020051
63MP0003111_abnormal_nucleus_morphology0.79758400
64MP0002139_abnormal_hepatobiliary_system0.78762862
65MP0001533_abnormal_skeleton_physiology0.75846177
66MP0008874_decreased_physiological_sensi0.74872196
67MP0000372_irregular_coat_pigmentation0.74289924
68MP0000371_diluted_coat_color0.73318748
69MP0008260_abnormal_autophagy0.72730008
70MP0000313_abnormal_cell_death0.72294031
71MP0008961_abnormal_basal_metabolism0.70261476
72MP0002928_abnormal_bile_duct0.70207303
73MP0001545_abnormal_hematopoietic_system0.68465333
74MP0005397_hematopoietic_system_phenotyp0.68465333
75MP0000350_abnormal_cell_proliferation0.67613514
76MP0002693_abnormal_pancreas_physiology0.66565714
77MP0006082_CNS_inflammation0.66481638
78MP0000465_gastrointestinal_hemorrhage0.66472480
79MP0002933_joint_inflammation0.62764593
80MP0001663_abnormal_digestive_system0.60694206
81MP0009763_increased_sensitivity_to0.58053796
82MP0002136_abnormal_kidney_physiology0.57468650
83MP0002998_abnormal_bone_remodeling0.55810174
84MP0005166_decreased_susceptibility_to0.55768799
85MP0005621_abnormal_cell_physiology0.55508856
86MP0000249_abnormal_blood_vessel0.54392808
87MP0003693_abnormal_embryo_hatching0.53564151
88MP0000609_abnormal_liver_physiology0.51983591
89MP0009278_abnormal_bone_marrow0.51557841
90MP0006035_abnormal_mitochondrial_morpho0.48936243
91MP0000015_abnormal_ear_pigmentation0.48429275
92MP0005379_endocrine/exocrine_gland_phen0.47769031
93MP0010307_abnormal_tumor_latency0.46764924
94MP0009764_decreased_sensitivity_to0.44193341
95MP0002083_premature_death0.43062439
96MP0009115_abnormal_fat_cell0.42264700
97MP0003221_abnormal_cardiomyocyte_apopto0.39868725
98MP0005384_cellular_phenotype0.39777278
99MP0002877_abnormal_melanocyte_morpholog0.39717482
100MP0001851_eye_inflammation0.39135151

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)8.97528592
2Agammaglobulinemia (HP:0004432)7.86233159
3Recurrent sinusitis (HP:0011108)7.01480871
4IgA deficiency (HP:0002720)5.56124569
5Lymphopenia (HP:0001888)5.55975858
6Meningitis (HP:0001287)5.53843445
7Recurrent bronchitis (HP:0002837)5.51645319
8IgM deficiency (HP:0002850)5.37831675
9Abnormality of cells of the lymphoid lineage (HP:0012140)5.16367822
10Cellulitis (HP:0100658)5.05595855
11Vasculitis (HP:0002633)4.97685856
12Emphysema (HP:0002097)4.95869331
13Colitis (HP:0002583)4.73424809
14Mediastinal lymphadenopathy (HP:0100721)4.50958217
15Recurrent viral infections (HP:0004429)4.48223744
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.33733397
17Panhypogammaglobulinemia (HP:0003139)4.29026588
18Restrictive lung disease (HP:0002091)4.20409372
19Recurrent pneumonia (HP:0006532)4.16785238
20Recurrent lower respiratory tract infections (HP:0002783)4.09473949
21IgG deficiency (HP:0004315)3.97200179
22Recurrent bacterial skin infections (HP:0005406)3.94517666
23Verrucae (HP:0200043)3.91249711
24Papilloma (HP:0012740)3.91249711
25Eczematoid dermatitis (HP:0000976)3.80529441
26Inflammation of the large intestine (HP:0002037)3.74869935
27Gastrointestinal inflammation (HP:0004386)3.69027175
28Osteomyelitis (HP:0002754)3.62226190
29Abnormality of T cell physiology (HP:0011840)3.55648591
30Chronic mucocutaneous candidiasis (HP:0002728)3.54533788
31Recurrent cutaneous fungal infections (HP:0011370)3.54533788
32Recurrent abscess formation (HP:0002722)3.47165729
33Chronic diarrhea (HP:0002028)3.42057908
34Recurrent fungal infections (HP:0002841)3.41058782
35Abnormality of macrophages (HP:0004311)3.32981193
36Lymphoma (HP:0002665)3.21942319
37B lymphocytopenia (HP:0010976)3.16172004
38Increased IgE level (HP:0003212)3.13998115
39Urticaria (HP:0001025)3.11669744
40Bronchitis (HP:0012387)3.10128939
41Leukopenia (HP:0001882)3.07344616
42Recurrent otitis media (HP:0000403)3.06297453
43Viral hepatitis (HP:0006562)3.04902071
44Abnormality of the prostate (HP:0008775)3.03100691
45Recurrent skin infections (HP:0001581)3.02989302
46Obstructive lung disease (HP:0006536)3.02540792
47Chronic obstructive pulmonary disease (HP:0006510)3.02540792
48Pulmonary infiltrates (HP:0002113)3.01203773
49Basal cell carcinoma (HP:0002671)3.01093742
50Encephalitis (HP:0002383)2.92457712
51Chronic otitis media (HP:0000389)2.88334092
52Sepsis (HP:0100806)2.85706181
53Skin rash (HP:0000988)2.85697583
54Increased IgM level (HP:0003496)2.84750896
55Abnormality of B cell number (HP:0010975)2.80100155
56Abnormality of T cells (HP:0002843)2.75753553
57Recurrent gram-negative bacterial infections (HP:0005420)2.68295257
58Hypertensive crisis (HP:0100735)2.62747793
59Squamous cell carcinoma (HP:0002860)2.55508450
60Arthralgia (HP:0002829)2.50717944
61Premature loss of primary teeth (HP:0006323)2.35810808
62Xerostomia (HP:0000217)2.35142022
63Chest pain (HP:0100749)2.35047468
64Chronic sinusitis (HP:0011109)2.32997753
65Hepatitis (HP:0012115)2.28889081
66Skin ulcer (HP:0200042)2.26973591
67Gastrointestinal infarctions (HP:0005244)2.23573999
68Pulmonary fibrosis (HP:0002206)2.21172600
69Dry hair (HP:0011359)2.19100408
70Spontaneous hematomas (HP:0007420)2.18644794
71Abnormality of male internal genitalia (HP:0000022)2.15598096
72Abnormality of the pleura (HP:0002103)2.15285703
73Hypergammaglobulinemia (HP:0010702)2.08495668
74Acrocyanosis (HP:0001063)2.08384263
75Optic neuritis (HP:0100653)2.07247899
76Retrobulbar optic neuritis (HP:0100654)2.07247899
77Neutropenia (HP:0001875)2.03908159
78Autoimmune hemolytic anemia (HP:0001890)2.02604326
79Teleangiectasia of the skin (HP:0100585)1.93382219
80Fatigue (HP:0012378)1.90996008
81Hemoptysis (HP:0002105)1.86547589
82Abnormality of the peritoneum (HP:0002585)1.82728327
83Bronchiectasis (HP:0002110)1.82085286
84Petechiae (HP:0000967)1.76202046
85Orchitis (HP:0100796)1.71282768
86Ureteral stenosis (HP:0000071)1.70342732
87Pustule (HP:0200039)1.70093886
88Granulocytopenia (HP:0001913)1.65808801
89Ureteral obstruction (HP:0006000)1.65570182
90Amaurosis fugax (HP:0100576)1.64712164
91Onycholysis (HP:0001806)1.64707549
92Abnormality of the fingertips (HP:0001211)1.62521763
93Deep palmar crease (HP:0006191)1.62342770
94Myositis (HP:0100614)1.61684997
95Poikiloderma (HP:0001029)1.61036506
96Conical tooth (HP:0000698)1.60552299
97Prostate neoplasm (HP:0100787)1.59980661
98Progressive external ophthalmoplegia (HP:0000590)1.58169266
99Villous atrophy (HP:0011473)1.57725831
100Abnormality of small intestinal villus morphology (HP:0011472)1.57725831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.18588023
2RIPK45.09350681
3PRPF4B3.66584162
4MAP3K142.95329026
5SMG12.69364165
6BLK2.65910191
7IRAK42.58069190
8MAP3K132.53499353
9SIK22.44819514
10MAP3K102.41791207
11SYK2.25620713
12NEK92.15563642
13CSF1R2.01950213
14TBK11.95839056
15SIK31.92868803
16BTK1.83706313
17NME21.80623004
18IKBKE1.79700363
19ERN11.78250371
20TYK21.74200714
21BMPR21.63140887
22IKBKB1.57030503
23PASK1.51826778
24JAK11.46471750
25VRK11.45053289
26LYN1.39651751
27CDK121.35565612
28KIT1.32844373
29TESK21.32413673
30CDK191.29760173
31EEF2K1.27408726
32TLK11.21736693
33JAK31.17432946
34PRKCQ1.14707524
35TAF11.10827393
36EIF2AK31.09237195
37CSK1.09171296
38MAP3K91.07222931
39TRIB31.05583726
40FGFR41.05294746
41CDK41.01024312
42ARAF1.00791749
43DAPK30.93419846
44CDC42BPA0.92302838
45CHUK0.91452050
46STK240.91244164
47MAPK110.90869640
48MATK0.89297737
49MARK30.88538346
50SIK10.88148221
51STK100.86119974
52PIM10.85633775
53TNK20.84518114
54HCK0.84125764
55FGR0.82899034
56MAPK120.76746060
57MAP3K80.74862308
58TAOK20.74759756
59CCNB10.73276845
60RPS6KA50.71333342
61LCK0.69548772
62MAPK70.67380508
63PDK10.66042372
64PRKCH0.64748365
65TEC0.63476662
66MELK0.63111219
67ZAK0.61784636
68JAK20.61463448
69ITK0.60752045
70HIPK20.57271064
71CDK90.54035590
72VRK20.54026516
73ALK0.53889395
74BRAF0.52690851
75FGFR30.51946021
76MAPK40.49186844
77PIM20.43133975
78BRD40.40396305
79CDC70.39909594
80KSR20.38886754
81LRRK20.38500362
82PDPK10.38460726
83TXK0.38179297
84GRK60.34068737
85BCKDK0.32919726
86MAPKAPK20.32814138
87PRKD20.32616189
88PKN10.32272187
89IRAK30.31806028
90INSR0.30132497
91PRKCD0.28991244
92ICK0.28989919
93FES0.28225504
94RPS6KB20.28121542
95PRKCI0.27193675
96AURKA0.26750172
97MAP3K10.25437833
98CAMKK10.24207176
99YES10.23657764
100MAP3K110.23326926

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.82808248
2Allograft rejection_Homo sapiens_hsa053304.74023321
3Autoimmune thyroid disease_Homo sapiens_hsa053204.39325248
4Asthma_Homo sapiens_hsa053104.31686580
5Graft-versus-host disease_Homo sapiens_hsa053324.09567940
6Primary immunodeficiency_Homo sapiens_hsa053403.96551461
7Type I diabetes mellitus_Homo sapiens_hsa049403.62217537
8B cell receptor signaling pathway_Homo sapiens_hsa046623.11113668
9Systemic lupus erythematosus_Homo sapiens_hsa053223.09041426
10Viral myocarditis_Homo sapiens_hsa054162.87031756
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76255822
12Leishmaniasis_Homo sapiens_hsa051402.69655515
13Antigen processing and presentation_Homo sapiens_hsa046122.54299927
14Staphylococcus aureus infection_Homo sapiens_hsa051502.25854881
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.88914532
16Herpes simplex infection_Homo sapiens_hsa051681.88073865
17Influenza A_Homo sapiens_hsa051641.73377975
18Toxoplasmosis_Homo sapiens_hsa051451.57448369
19Tuberculosis_Homo sapiens_hsa051521.46667304
20Rheumatoid arthritis_Homo sapiens_hsa053231.41118243
21Measles_Homo sapiens_hsa051621.38989007
22* Epstein-Barr virus infection_Homo sapiens_hsa051691.38082153
23Alcoholism_Homo sapiens_hsa050341.35855467
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33728844
25Osteoclast differentiation_Homo sapiens_hsa043801.32486538
26Viral carcinogenesis_Homo sapiens_hsa052031.27175905
27* Hematopoietic cell lineage_Homo sapiens_hsa046401.22544433
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05847019
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02862273
30T cell receptor signaling pathway_Homo sapiens_hsa046601.01708351
31HTLV-I infection_Homo sapiens_hsa051661.00033184
32Hepatitis B_Homo sapiens_hsa051610.99354891
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99188689
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95382099
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89430919
36Apoptosis_Homo sapiens_hsa042100.87504794
37Phagosome_Homo sapiens_hsa041450.81955920
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76397243
39Chemokine signaling pathway_Homo sapiens_hsa040620.72150781
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71246861
41Acute myeloid leukemia_Homo sapiens_hsa052210.70130846
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.69195458
43TNF signaling pathway_Homo sapiens_hsa046680.68363203
44Hepatitis C_Homo sapiens_hsa051600.67050113
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55652336
46Shigellosis_Homo sapiens_hsa051310.55068666
47Non-small cell lung cancer_Homo sapiens_hsa052230.50761417
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.50638554
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50191586
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46319671
51p53 signaling pathway_Homo sapiens_hsa041150.43308959
52DNA replication_Homo sapiens_hsa030300.42606375
53Chronic myeloid leukemia_Homo sapiens_hsa052200.39332792
54Pancreatic cancer_Homo sapiens_hsa052120.38289398
55Base excision repair_Homo sapiens_hsa034100.38165127
56Ribosome_Homo sapiens_hsa030100.36446738
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.34059576
58African trypanosomiasis_Homo sapiens_hsa051430.33754603
59Pentose phosphate pathway_Homo sapiens_hsa000300.33701592
60Prolactin signaling pathway_Homo sapiens_hsa049170.32313737
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30408344
62Other glycan degradation_Homo sapiens_hsa005110.28533656
63Spliceosome_Homo sapiens_hsa030400.28428038
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26222966
65Colorectal cancer_Homo sapiens_hsa052100.25715332
66HIF-1 signaling pathway_Homo sapiens_hsa040660.25202224
67Malaria_Homo sapiens_hsa051440.24565378
68Renal cell carcinoma_Homo sapiens_hsa052110.24066684
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.24003880
70Prostate cancer_Homo sapiens_hsa052150.23837275
71Legionellosis_Homo sapiens_hsa051340.22376520
72VEGF signaling pathway_Homo sapiens_hsa043700.22256313
73Small cell lung cancer_Homo sapiens_hsa052220.19554322
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19365792
75Platelet activation_Homo sapiens_hsa046110.19330234
76Mismatch repair_Homo sapiens_hsa034300.16987574
77MAPK signaling pathway_Homo sapiens_hsa040100.16965509
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14558113
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13204497
80Fructose and mannose metabolism_Homo sapiens_hsa000510.11638629
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10379773
82Endometrial cancer_Homo sapiens_hsa052130.09652887
83GnRH signaling pathway_Homo sapiens_hsa049120.08936927
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.06910517
85Salmonella infection_Homo sapiens_hsa051320.06707830
86Nucleotide excision repair_Homo sapiens_hsa034200.06697635
87mRNA surveillance pathway_Homo sapiens_hsa030150.06279761
88Pertussis_Homo sapiens_hsa051330.05555492
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05199099
90Type II diabetes mellitus_Homo sapiens_hsa049300.04506811
91Homologous recombination_Homo sapiens_hsa034400.04403194
92Non-homologous end-joining_Homo sapiens_hsa034500.04137200
93Inositol phosphate metabolism_Homo sapiens_hsa005620.02957676
94mTOR signaling pathway_Homo sapiens_hsa041500.02685997
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.02667406
96One carbon pool by folate_Homo sapiens_hsa006700.02259613
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01359865
98RNA degradation_Homo sapiens_hsa030180.01181781
99Bladder cancer_Homo sapiens_hsa052190.00657837
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.00620932

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