Rank | Gene Set | Z-score |
---|---|---|
1 | B cell receptor signaling pathway (GO:0050853) | 6.63129457 |
2 | regulation of B cell receptor signaling pathway (GO:0050855) | 6.56431542 |
3 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 5.75136620 |
4 | immunoglobulin mediated immune response (GO:0016064) | 5.63499769 |
5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.38374585 |
6 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.35415350 |
7 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 5.27929427 |
8 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 5.16155238 |
9 | B cell homeostasis (GO:0001782) | 5.06177412 |
10 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.93989883 |
11 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.92642057 |
12 | T-helper 1 type immune response (GO:0042088) | 4.78990689 |
13 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.77520618 |
14 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.77520618 |
15 | modulation by symbiont of host immune response (GO:0052553) | 4.77520618 |
16 | positive regulation by symbiont of host defense response (GO:0052509) | 4.77520618 |
17 | modulation by symbiont of host defense response (GO:0052031) | 4.77520618 |
18 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.77520618 |
19 | B cell mediated immunity (GO:0019724) | 4.71592342 |
20 | interferon-gamma-mediated signaling pathway (GO:0060333) | 4.70088285 |
21 | B cell proliferation (GO:0042100) | 4.56213451 |
22 | NIK/NF-kappaB signaling (GO:0038061) | 4.54938741 |
23 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 4.42861701 |
24 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.38787037 |
25 | negative thymic T cell selection (GO:0045060) | 4.36346339 |
26 | positive regulation of B cell differentiation (GO:0045579) | 4.34273468 |
27 | type I interferon signaling pathway (GO:0060337) | 4.26939464 |
28 | cellular response to type I interferon (GO:0071357) | 4.26939464 |
29 | response to type I interferon (GO:0034340) | 4.24856675 |
30 | T cell lineage commitment (GO:0002360) | 4.22396985 |
31 | detection of bacterium (GO:0016045) | 4.19710172 |
32 | positive thymic T cell selection (GO:0045059) | 4.17649130 |
33 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.15114168 |
34 | regulation of antigen processing and presentation (GO:0002577) | 4.06438709 |
35 | defense response to protozoan (GO:0042832) | 4.06351807 |
36 | regulation of B cell differentiation (GO:0045577) | 4.05301417 |
37 | T cell migration (GO:0072678) | 4.04474633 |
38 | response to protozoan (GO:0001562) | 4.02790683 |
39 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.02727377 |
40 | negative regulation of cell killing (GO:0031342) | 4.02727377 |
41 | T cell costimulation (GO:0031295) | 4.00573860 |
42 | negative T cell selection (GO:0043383) | 3.96453865 |
43 | thymic T cell selection (GO:0045061) | 3.96260998 |
44 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.94796754 |
45 | lymphocyte costimulation (GO:0031294) | 3.94782256 |
46 | myeloid dendritic cell differentiation (GO:0043011) | 3.89670618 |
47 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.83893853 |
48 | detection of other organism (GO:0098543) | 3.83693963 |
49 | positive regulation of interferon-alpha production (GO:0032727) | 3.77849613 |
50 | negative regulation of B cell proliferation (GO:0030889) | 3.75881772 |
51 | regulation of gamma-delta T cell activation (GO:0046643) | 3.74067274 |
52 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.73726414 |
53 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.72700898 |
54 | regulation of B cell proliferation (GO:0030888) | 3.72160348 |
55 | myeloid dendritic cell activation (GO:0001773) | 3.71925660 |
56 | cellular response to interferon-gamma (GO:0071346) | 3.55441999 |
57 | regulation of interferon-alpha production (GO:0032647) | 3.54550497 |
58 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.53295547 |
59 | positive regulation of B cell proliferation (GO:0030890) | 3.50811405 |
60 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.49361720 |
61 | lymphocyte homeostasis (GO:0002260) | 3.48959676 |
62 | positive regulation of macrophage cytokine production (GO:0060907) | 3.44227440 |
63 | cellular response to interleukin-15 (GO:0071350) | 3.43315017 |
64 | response to muramyl dipeptide (GO:0032495) | 3.37564351 |
65 | response to host immune response (GO:0052572) | 3.36288796 |
66 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.36288796 |
67 | negative regulation of phagocytosis (GO:0050765) | 3.34361903 |
68 | positive regulation of B cell activation (GO:0050871) | 3.30487205 |
69 | macrophage activation involved in immune response (GO:0002281) | 3.30063310 |
70 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.25947641 |
71 | positive regulation of type 2 immune response (GO:0002830) | 3.24518568 |
72 | response to interleukin-15 (GO:0070672) | 3.24020841 |
73 | T cell selection (GO:0045058) | 3.23047125 |
74 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.22856033 |
75 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 3.17503579 |
76 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.13661162 |
77 | germinal center formation (GO:0002467) | 3.12634289 |
78 | regulation of B cell apoptotic process (GO:0002902) | 3.11324665 |
79 | positive regulation of cytokine biosynthetic process (GO:0042108) | 3.08888056 |
80 | response to host (GO:0075136) | 3.06928654 |
81 | response to host defenses (GO:0052200) | 3.06928654 |
82 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.06928654 |
83 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.05805308 |
84 | regulation of B cell activation (GO:0050864) | 3.05566391 |
85 | positive regulation of antigen processing and presentation (GO:0002579) | 3.04302935 |
86 | positive T cell selection (GO:0043368) | 3.03933030 |
87 | cytidine metabolic process (GO:0046087) | 3.02216087 |
88 | cytidine catabolic process (GO:0006216) | 3.02216087 |
89 | cytidine deamination (GO:0009972) | 3.02216087 |
90 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.01298172 |
91 | mature B cell differentiation (GO:0002335) | 2.99961567 |
92 | positive regulation of interleukin-2 production (GO:0032743) | 2.99627490 |
93 | response to interferon-gamma (GO:0034341) | 2.98428366 |
94 | leukocyte homeostasis (GO:0001776) | 2.96441243 |
95 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.94820085 |
96 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.93901722 |
97 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.93234102 |
98 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.92361746 |
99 | positive regulation of protein homooligomerization (GO:0032464) | 2.90918611 |
100 | positive regulation of interferon-gamma production (GO:0032729) | 2.89523171 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.08157582 |
2 | MYC_22102868_ChIP-Seq_BL_Human | 5.04135368 |
3 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.80338872 |
4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.72720458 |
5 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.36521395 |
6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.23396648 |
7 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.91811399 |
8 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.82675958 |
9 | MAF_26560356_Chip-Seq_TH1_Human | 2.82438851 |
10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.81746666 |
11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.79091220 |
12 | CIITA_25753668_ChIP-Seq_RAJI_Human | 2.77751621 |
13 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.66279160 |
14 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.59249470 |
15 | * STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.55160543 |
16 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.49002141 |
17 | * MYB_26560356_Chip-Seq_TH2_Human | 2.44609231 |
18 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.41854875 |
19 | * MYB_26560356_Chip-Seq_TH1_Human | 2.34638454 |
20 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.30486416 |
21 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.25375703 |
22 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.24387085 |
23 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.17247858 |
24 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.13608012 |
25 | UTX_26944678_Chip-Seq_JUKART_Human | 2.11735234 |
26 | MAF_26560356_Chip-Seq_TH2_Human | 2.02302492 |
27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.97451132 |
28 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.94257231 |
29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.91881022 |
30 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.91154063 |
31 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.90742183 |
32 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.82995770 |
33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.82341567 |
34 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.81793427 |
35 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.80125074 |
36 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.78981603 |
37 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.77258827 |
38 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.76997793 |
39 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.75853601 |
40 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.72266802 |
41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70352732 |
42 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.69910450 |
43 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.68873921 |
44 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.68429384 |
45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68108018 |
46 | GATA1_22025678_ChIP-Seq_K562_Human | 1.67756663 |
47 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.67562750 |
48 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.66249916 |
49 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.63827677 |
50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.63462026 |
51 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.62251607 |
52 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59145665 |
53 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.58485710 |
54 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.51768981 |
55 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.50325825 |
56 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.43551417 |
57 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.41718535 |
58 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.41640135 |
59 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.41363035 |
60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37719673 |
61 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.36524720 |
62 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35636175 |
63 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.31857299 |
64 | SPI1_23127762_ChIP-Seq_K562_Human | 1.26736307 |
65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.26526296 |
66 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.22990844 |
67 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.18588173 |
68 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.13174325 |
69 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.12092411 |
70 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.11726346 |
71 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.11593924 |
72 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.06289849 |
73 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.05307873 |
74 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.03324889 |
75 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.03035989 |
76 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.02466974 |
77 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.01681720 |
78 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.00723296 |
79 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00075047 |
80 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.97983182 |
81 | GATA3_26560356_Chip-Seq_TH2_Human | 0.95999910 |
82 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.95759929 |
83 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.95160379 |
84 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92912717 |
85 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.91645731 |
86 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.91597735 |
87 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91226489 |
88 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.90888568 |
89 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.90887902 |
90 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90751630 |
91 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90059765 |
92 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.89886827 |
93 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.89753094 |
94 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.89602886 |
95 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.88497142 |
96 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.88090604 |
97 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.87375315 |
98 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.86955225 |
99 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.86792054 |
100 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.86304574 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0000685_abnormal_immune_system | 5.03903364 |
2 | MP0005671_abnormal_response_to | 4.77006029 |
3 | MP0001835_abnormal_antigen_presentation | 4.50713205 |
4 | MP0001790_abnormal_immune_system | 4.41027644 |
5 | MP0005387_immune_system_phenotype | 4.41027644 |
6 | MP0001800_abnormal_humoral_immune | 4.08849874 |
7 | MP0003303_peritoneal_inflammation | 3.46416428 |
8 | MP0005000_abnormal_immune_tolerance | 3.33960388 |
9 | MP0002452_abnormal_antigen_presenting | 3.11823066 |
10 | MP0002723_abnormal_immune_serum | 3.00839327 |
11 | MP0005645_abnormal_hypothalamus_physiol | 2.98997556 |
12 | MP0003763_abnormal_thymus_physiology | 2.96728275 |
13 | MP0002138_abnormal_hepatobiliary_system | 2.90244540 |
14 | MP0002420_abnormal_adaptive_immunity | 2.82459096 |
15 | MP0001819_abnormal_immune_cell | 2.76827661 |
16 | MP0002398_abnormal_bone_marrow | 2.60184441 |
17 | MP0003436_decreased_susceptibility_to | 2.56912069 |
18 | MP0005025_abnormal_response_to | 2.40529234 |
19 | MP0002166_altered_tumor_susceptibility | 2.36068883 |
20 | MP0000716_abnormal_immune_system | 2.35557735 |
21 | MP0009785_altered_susceptibility_to | 2.26119163 |
22 | MP0002148_abnormal_hypersensitivity_rea | 2.09432495 |
23 | MP0000689_abnormal_spleen_morphology | 2.09047995 |
24 | MP0002419_abnormal_innate_immunity | 2.07100760 |
25 | MP0005310_abnormal_salivary_gland | 2.01197658 |
26 | MP0003300_gastrointestinal_ulcer | 1.97598695 |
27 | MP0003183_abnormal_peptide_metabolism | 1.96124240 |
28 | MP0002429_abnormal_blood_cell | 1.95091564 |
29 | MP0002722_abnormal_immune_system | 1.86254630 |
30 | MP0001348_abnormal_lacrimal_gland | 1.81529034 |
31 | MP0010155_abnormal_intestine_physiology | 1.73915318 |
32 | MP0001873_stomach_inflammation | 1.72585792 |
33 | MP0009333_abnormal_splenocyte_physiolog | 1.71065806 |
34 | MP0002405_respiratory_system_inflammati | 1.67607814 |
35 | MP0001845_abnormal_inflammatory_respons | 1.67253727 |
36 | MP0002006_tumorigenesis | 1.64602751 |
37 | MP0008057_abnormal_DNA_replication | 1.60130798 |
38 | MP0000703_abnormal_thymus_morphology | 1.57132572 |
39 | MP0004947_skin_inflammation | 1.49259896 |
40 | MP0005451_abnormal_body_composition | 1.47138121 |
41 | MP0002396_abnormal_hematopoietic_system | 1.41776660 |
42 | MP0005464_abnormal_platelet_physiology | 1.39827004 |
43 | MP0001853_heart_inflammation | 1.21978200 |
44 | MP0003724_increased_susceptibility_to | 1.16264487 |
45 | MP0010094_abnormal_chromosome_stability | 1.13161632 |
46 | MP0004510_myositis | 1.12649161 |
47 | MP0003091_abnormal_cell_migration | 1.10779013 |
48 | MP0002019_abnormal_tumor_incidence | 1.08045137 |
49 | MP0008469_abnormal_protein_level | 1.06462848 |
50 | MP0002163_abnormal_gland_morphology | 1.03419771 |
51 | MP0003045_fibrosis | 1.03339361 |
52 | MP0000490_abnormal_crypts_of | 1.01558777 |
53 | MP0003077_abnormal_cell_cycle | 0.94561958 |
54 | MP0003172_abnormal_lysosome_physiology | 0.92321709 |
55 | MP0001727_abnormal_embryo_implantation | 0.88681627 |
56 | MP0004381_abnormal_hair_follicle | 0.87699620 |
57 | MP0005623_abnormal_meninges_morphology | 0.87652212 |
58 | MP0000858_altered_metastatic_potential | 0.86914597 |
59 | MP0005075_abnormal_melanosome_morpholog | 0.86805252 |
60 | MP0002009_preneoplasia | 0.85299800 |
61 | MP0004808_abnormal_hematopoietic_stem | 0.81849642 |
62 | MP0003866_abnormal_defecation | 0.81020051 |
63 | MP0003111_abnormal_nucleus_morphology | 0.79758400 |
64 | MP0002139_abnormal_hepatobiliary_system | 0.78762862 |
65 | MP0001533_abnormal_skeleton_physiology | 0.75846177 |
66 | MP0008874_decreased_physiological_sensi | 0.74872196 |
67 | MP0000372_irregular_coat_pigmentation | 0.74289924 |
68 | MP0000371_diluted_coat_color | 0.73318748 |
69 | MP0008260_abnormal_autophagy | 0.72730008 |
70 | MP0000313_abnormal_cell_death | 0.72294031 |
71 | MP0008961_abnormal_basal_metabolism | 0.70261476 |
72 | MP0002928_abnormal_bile_duct | 0.70207303 |
73 | MP0001545_abnormal_hematopoietic_system | 0.68465333 |
74 | MP0005397_hematopoietic_system_phenotyp | 0.68465333 |
75 | MP0000350_abnormal_cell_proliferation | 0.67613514 |
76 | MP0002693_abnormal_pancreas_physiology | 0.66565714 |
77 | MP0006082_CNS_inflammation | 0.66481638 |
78 | MP0000465_gastrointestinal_hemorrhage | 0.66472480 |
79 | MP0002933_joint_inflammation | 0.62764593 |
80 | MP0001663_abnormal_digestive_system | 0.60694206 |
81 | MP0009763_increased_sensitivity_to | 0.58053796 |
82 | MP0002136_abnormal_kidney_physiology | 0.57468650 |
83 | MP0002998_abnormal_bone_remodeling | 0.55810174 |
84 | MP0005166_decreased_susceptibility_to | 0.55768799 |
85 | MP0005621_abnormal_cell_physiology | 0.55508856 |
86 | MP0000249_abnormal_blood_vessel | 0.54392808 |
87 | MP0003693_abnormal_embryo_hatching | 0.53564151 |
88 | MP0000609_abnormal_liver_physiology | 0.51983591 |
89 | MP0009278_abnormal_bone_marrow | 0.51557841 |
90 | MP0006035_abnormal_mitochondrial_morpho | 0.48936243 |
91 | MP0000015_abnormal_ear_pigmentation | 0.48429275 |
92 | MP0005379_endocrine/exocrine_gland_phen | 0.47769031 |
93 | MP0010307_abnormal_tumor_latency | 0.46764924 |
94 | MP0009764_decreased_sensitivity_to | 0.44193341 |
95 | MP0002083_premature_death | 0.43062439 |
96 | MP0009115_abnormal_fat_cell | 0.42264700 |
97 | MP0003221_abnormal_cardiomyocyte_apopto | 0.39868725 |
98 | MP0005384_cellular_phenotype | 0.39777278 |
99 | MP0002877_abnormal_melanocyte_morpholog | 0.39717482 |
100 | MP0001851_eye_inflammation | 0.39135151 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Gastrointestinal stroma tumor (HP:0100723) | 8.97528592 |
2 | Agammaglobulinemia (HP:0004432) | 7.86233159 |
3 | Recurrent sinusitis (HP:0011108) | 7.01480871 |
4 | IgA deficiency (HP:0002720) | 5.56124569 |
5 | Lymphopenia (HP:0001888) | 5.55975858 |
6 | Meningitis (HP:0001287) | 5.53843445 |
7 | Recurrent bronchitis (HP:0002837) | 5.51645319 |
8 | IgM deficiency (HP:0002850) | 5.37831675 |
9 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 5.16367822 |
10 | Cellulitis (HP:0100658) | 5.05595855 |
11 | Vasculitis (HP:0002633) | 4.97685856 |
12 | Emphysema (HP:0002097) | 4.95869331 |
13 | Colitis (HP:0002583) | 4.73424809 |
14 | Mediastinal lymphadenopathy (HP:0100721) | 4.50958217 |
15 | Recurrent viral infections (HP:0004429) | 4.48223744 |
16 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.33733397 |
17 | Panhypogammaglobulinemia (HP:0003139) | 4.29026588 |
18 | Restrictive lung disease (HP:0002091) | 4.20409372 |
19 | Recurrent pneumonia (HP:0006532) | 4.16785238 |
20 | Recurrent lower respiratory tract infections (HP:0002783) | 4.09473949 |
21 | IgG deficiency (HP:0004315) | 3.97200179 |
22 | Recurrent bacterial skin infections (HP:0005406) | 3.94517666 |
23 | Verrucae (HP:0200043) | 3.91249711 |
24 | Papilloma (HP:0012740) | 3.91249711 |
25 | Eczematoid dermatitis (HP:0000976) | 3.80529441 |
26 | Inflammation of the large intestine (HP:0002037) | 3.74869935 |
27 | Gastrointestinal inflammation (HP:0004386) | 3.69027175 |
28 | Osteomyelitis (HP:0002754) | 3.62226190 |
29 | Abnormality of T cell physiology (HP:0011840) | 3.55648591 |
30 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.54533788 |
31 | Recurrent cutaneous fungal infections (HP:0011370) | 3.54533788 |
32 | Recurrent abscess formation (HP:0002722) | 3.47165729 |
33 | Chronic diarrhea (HP:0002028) | 3.42057908 |
34 | Recurrent fungal infections (HP:0002841) | 3.41058782 |
35 | Abnormality of macrophages (HP:0004311) | 3.32981193 |
36 | Lymphoma (HP:0002665) | 3.21942319 |
37 | B lymphocytopenia (HP:0010976) | 3.16172004 |
38 | Increased IgE level (HP:0003212) | 3.13998115 |
39 | Urticaria (HP:0001025) | 3.11669744 |
40 | Bronchitis (HP:0012387) | 3.10128939 |
41 | Leukopenia (HP:0001882) | 3.07344616 |
42 | Recurrent otitis media (HP:0000403) | 3.06297453 |
43 | Viral hepatitis (HP:0006562) | 3.04902071 |
44 | Abnormality of the prostate (HP:0008775) | 3.03100691 |
45 | Recurrent skin infections (HP:0001581) | 3.02989302 |
46 | Obstructive lung disease (HP:0006536) | 3.02540792 |
47 | Chronic obstructive pulmonary disease (HP:0006510) | 3.02540792 |
48 | Pulmonary infiltrates (HP:0002113) | 3.01203773 |
49 | Basal cell carcinoma (HP:0002671) | 3.01093742 |
50 | Encephalitis (HP:0002383) | 2.92457712 |
51 | Chronic otitis media (HP:0000389) | 2.88334092 |
52 | Sepsis (HP:0100806) | 2.85706181 |
53 | Skin rash (HP:0000988) | 2.85697583 |
54 | Increased IgM level (HP:0003496) | 2.84750896 |
55 | Abnormality of B cell number (HP:0010975) | 2.80100155 |
56 | Abnormality of T cells (HP:0002843) | 2.75753553 |
57 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.68295257 |
58 | Hypertensive crisis (HP:0100735) | 2.62747793 |
59 | Squamous cell carcinoma (HP:0002860) | 2.55508450 |
60 | Arthralgia (HP:0002829) | 2.50717944 |
61 | Premature loss of primary teeth (HP:0006323) | 2.35810808 |
62 | Xerostomia (HP:0000217) | 2.35142022 |
63 | Chest pain (HP:0100749) | 2.35047468 |
64 | Chronic sinusitis (HP:0011109) | 2.32997753 |
65 | Hepatitis (HP:0012115) | 2.28889081 |
66 | Skin ulcer (HP:0200042) | 2.26973591 |
67 | Gastrointestinal infarctions (HP:0005244) | 2.23573999 |
68 | Pulmonary fibrosis (HP:0002206) | 2.21172600 |
69 | Dry hair (HP:0011359) | 2.19100408 |
70 | Spontaneous hematomas (HP:0007420) | 2.18644794 |
71 | Abnormality of male internal genitalia (HP:0000022) | 2.15598096 |
72 | Abnormality of the pleura (HP:0002103) | 2.15285703 |
73 | Hypergammaglobulinemia (HP:0010702) | 2.08495668 |
74 | Acrocyanosis (HP:0001063) | 2.08384263 |
75 | Optic neuritis (HP:0100653) | 2.07247899 |
76 | Retrobulbar optic neuritis (HP:0100654) | 2.07247899 |
77 | Neutropenia (HP:0001875) | 2.03908159 |
78 | Autoimmune hemolytic anemia (HP:0001890) | 2.02604326 |
79 | Teleangiectasia of the skin (HP:0100585) | 1.93382219 |
80 | Fatigue (HP:0012378) | 1.90996008 |
81 | Hemoptysis (HP:0002105) | 1.86547589 |
82 | Abnormality of the peritoneum (HP:0002585) | 1.82728327 |
83 | Bronchiectasis (HP:0002110) | 1.82085286 |
84 | Petechiae (HP:0000967) | 1.76202046 |
85 | Orchitis (HP:0100796) | 1.71282768 |
86 | Ureteral stenosis (HP:0000071) | 1.70342732 |
87 | Pustule (HP:0200039) | 1.70093886 |
88 | Granulocytopenia (HP:0001913) | 1.65808801 |
89 | Ureteral obstruction (HP:0006000) | 1.65570182 |
90 | Amaurosis fugax (HP:0100576) | 1.64712164 |
91 | Onycholysis (HP:0001806) | 1.64707549 |
92 | Abnormality of the fingertips (HP:0001211) | 1.62521763 |
93 | Deep palmar crease (HP:0006191) | 1.62342770 |
94 | Myositis (HP:0100614) | 1.61684997 |
95 | Poikiloderma (HP:0001029) | 1.61036506 |
96 | Conical tooth (HP:0000698) | 1.60552299 |
97 | Prostate neoplasm (HP:0100787) | 1.59980661 |
98 | Progressive external ophthalmoplegia (HP:0000590) | 1.58169266 |
99 | Villous atrophy (HP:0011473) | 1.57725831 |
100 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.57725831 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP4K1 | 5.18588023 |
2 | RIPK4 | 5.09350681 |
3 | PRPF4B | 3.66584162 |
4 | MAP3K14 | 2.95329026 |
5 | SMG1 | 2.69364165 |
6 | BLK | 2.65910191 |
7 | IRAK4 | 2.58069190 |
8 | MAP3K13 | 2.53499353 |
9 | SIK2 | 2.44819514 |
10 | MAP3K10 | 2.41791207 |
11 | SYK | 2.25620713 |
12 | NEK9 | 2.15563642 |
13 | CSF1R | 2.01950213 |
14 | TBK1 | 1.95839056 |
15 | SIK3 | 1.92868803 |
16 | BTK | 1.83706313 |
17 | NME2 | 1.80623004 |
18 | IKBKE | 1.79700363 |
19 | ERN1 | 1.78250371 |
20 | TYK2 | 1.74200714 |
21 | BMPR2 | 1.63140887 |
22 | IKBKB | 1.57030503 |
23 | PASK | 1.51826778 |
24 | JAK1 | 1.46471750 |
25 | VRK1 | 1.45053289 |
26 | LYN | 1.39651751 |
27 | CDK12 | 1.35565612 |
28 | KIT | 1.32844373 |
29 | TESK2 | 1.32413673 |
30 | CDK19 | 1.29760173 |
31 | EEF2K | 1.27408726 |
32 | TLK1 | 1.21736693 |
33 | JAK3 | 1.17432946 |
34 | PRKCQ | 1.14707524 |
35 | TAF1 | 1.10827393 |
36 | EIF2AK3 | 1.09237195 |
37 | CSK | 1.09171296 |
38 | MAP3K9 | 1.07222931 |
39 | TRIB3 | 1.05583726 |
40 | FGFR4 | 1.05294746 |
41 | CDK4 | 1.01024312 |
42 | ARAF | 1.00791749 |
43 | DAPK3 | 0.93419846 |
44 | CDC42BPA | 0.92302838 |
45 | CHUK | 0.91452050 |
46 | STK24 | 0.91244164 |
47 | MAPK11 | 0.90869640 |
48 | MATK | 0.89297737 |
49 | MARK3 | 0.88538346 |
50 | SIK1 | 0.88148221 |
51 | STK10 | 0.86119974 |
52 | PIM1 | 0.85633775 |
53 | TNK2 | 0.84518114 |
54 | HCK | 0.84125764 |
55 | FGR | 0.82899034 |
56 | MAPK12 | 0.76746060 |
57 | MAP3K8 | 0.74862308 |
58 | TAOK2 | 0.74759756 |
59 | CCNB1 | 0.73276845 |
60 | RPS6KA5 | 0.71333342 |
61 | LCK | 0.69548772 |
62 | MAPK7 | 0.67380508 |
63 | PDK1 | 0.66042372 |
64 | PRKCH | 0.64748365 |
65 | TEC | 0.63476662 |
66 | MELK | 0.63111219 |
67 | ZAK | 0.61784636 |
68 | JAK2 | 0.61463448 |
69 | ITK | 0.60752045 |
70 | HIPK2 | 0.57271064 |
71 | CDK9 | 0.54035590 |
72 | VRK2 | 0.54026516 |
73 | ALK | 0.53889395 |
74 | BRAF | 0.52690851 |
75 | FGFR3 | 0.51946021 |
76 | MAPK4 | 0.49186844 |
77 | PIM2 | 0.43133975 |
78 | BRD4 | 0.40396305 |
79 | CDC7 | 0.39909594 |
80 | KSR2 | 0.38886754 |
81 | LRRK2 | 0.38500362 |
82 | PDPK1 | 0.38460726 |
83 | TXK | 0.38179297 |
84 | GRK6 | 0.34068737 |
85 | BCKDK | 0.32919726 |
86 | MAPKAPK2 | 0.32814138 |
87 | PRKD2 | 0.32616189 |
88 | PKN1 | 0.32272187 |
89 | IRAK3 | 0.31806028 |
90 | INSR | 0.30132497 |
91 | PRKCD | 0.28991244 |
92 | ICK | 0.28989919 |
93 | FES | 0.28225504 |
94 | RPS6KB2 | 0.28121542 |
95 | PRKCI | 0.27193675 |
96 | AURKA | 0.26750172 |
97 | MAP3K1 | 0.25437833 |
98 | CAMKK1 | 0.24207176 |
99 | YES1 | 0.23657764 |
100 | MAP3K11 | 0.23326926 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 4.82808248 |
2 | Allograft rejection_Homo sapiens_hsa05330 | 4.74023321 |
3 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 4.39325248 |
4 | Asthma_Homo sapiens_hsa05310 | 4.31686580 |
5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.09567940 |
6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.96551461 |
7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.62217537 |
8 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.11113668 |
9 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 3.09041426 |
10 | Viral myocarditis_Homo sapiens_hsa05416 | 2.87031756 |
11 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.76255822 |
12 | Leishmaniasis_Homo sapiens_hsa05140 | 2.69655515 |
13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.54299927 |
14 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.25854881 |
15 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.88914532 |
16 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.88073865 |
17 | Influenza A_Homo sapiens_hsa05164 | 1.73377975 |
18 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.57448369 |
19 | Tuberculosis_Homo sapiens_hsa05152 | 1.46667304 |
20 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.41118243 |
21 | Measles_Homo sapiens_hsa05162 | 1.38989007 |
22 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.38082153 |
23 | Alcoholism_Homo sapiens_hsa05034 | 1.35855467 |
24 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.33728844 |
25 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.32486538 |
26 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.27175905 |
27 | * Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.22544433 |
28 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.05847019 |
29 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.02862273 |
30 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.01708351 |
31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.00033184 |
32 | Hepatitis B_Homo sapiens_hsa05161 | 0.99354891 |
33 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.99188689 |
34 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.95382099 |
35 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.89430919 |
36 | Apoptosis_Homo sapiens_hsa04210 | 0.87504794 |
37 | Phagosome_Homo sapiens_hsa04145 | 0.81955920 |
38 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.76397243 |
39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.72150781 |
40 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.71246861 |
41 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.70130846 |
42 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.69195458 |
43 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.68363203 |
44 | Hepatitis C_Homo sapiens_hsa05160 | 0.67050113 |
45 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55652336 |
46 | Shigellosis_Homo sapiens_hsa05131 | 0.55068666 |
47 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.50761417 |
48 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50638554 |
49 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.50191586 |
50 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.46319671 |
51 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.43308959 |
52 | DNA replication_Homo sapiens_hsa03030 | 0.42606375 |
53 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.39332792 |
54 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.38289398 |
55 | Base excision repair_Homo sapiens_hsa03410 | 0.38165127 |
56 | Ribosome_Homo sapiens_hsa03010 | 0.36446738 |
57 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.34059576 |
58 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.33754603 |
59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.33701592 |
60 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.32313737 |
61 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.30408344 |
62 | Other glycan degradation_Homo sapiens_hsa00511 | 0.28533656 |
63 | Spliceosome_Homo sapiens_hsa03040 | 0.28428038 |
64 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.26222966 |
65 | Colorectal cancer_Homo sapiens_hsa05210 | 0.25715332 |
66 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.25202224 |
67 | Malaria_Homo sapiens_hsa05144 | 0.24565378 |
68 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.24066684 |
69 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.24003880 |
70 | Prostate cancer_Homo sapiens_hsa05215 | 0.23837275 |
71 | Legionellosis_Homo sapiens_hsa05134 | 0.22376520 |
72 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.22256313 |
73 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.19554322 |
74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.19365792 |
75 | Platelet activation_Homo sapiens_hsa04611 | 0.19330234 |
76 | Mismatch repair_Homo sapiens_hsa03430 | 0.16987574 |
77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.16965509 |
78 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.14558113 |
79 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.13204497 |
80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.11638629 |
81 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.10379773 |
82 | Endometrial cancer_Homo sapiens_hsa05213 | 0.09652887 |
83 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.08936927 |
84 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.06910517 |
85 | Salmonella infection_Homo sapiens_hsa05132 | 0.06707830 |
86 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.06697635 |
87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.06279761 |
88 | Pertussis_Homo sapiens_hsa05133 | 0.05555492 |
89 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.05199099 |
90 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.04506811 |
91 | Homologous recombination_Homo sapiens_hsa03440 | 0.04403194 |
92 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.04137200 |
93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.02957676 |
94 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.02685997 |
95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.02667406 |
96 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.02259613 |
97 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.01359865 |
98 | RNA degradation_Homo sapiens_hsa03018 | 0.01181781 |
99 | Bladder cancer_Homo sapiens_hsa05219 | 0.00657837 |
100 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.00620932 |