FCF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)6.43920102
2positive regulation of fibroblast migration (GO:0010763)6.14920301
3positive regulation of muscle hypertrophy (GO:0014742)5.78074024
4positive regulation of cardiac muscle hypertrophy (GO:0010613)5.78074024
5negative regulation of sodium ion transport (GO:0010766)5.67511741
6regulation of cell communication by electrical coupling (GO:0010649)5.42603407
7keratinocyte development (GO:0003334)5.18977310
8relaxation of cardiac muscle (GO:0055119)5.18239581
9lactate metabolic process (GO:0006089)4.94363885
10regulation of action potential (GO:0098900)4.60785075
11phospholipid efflux (GO:0033700)4.56003593
12S-adenosylmethionine metabolic process (GO:0046500)4.47684168
13regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.43126802
14regulation of triglyceride catabolic process (GO:0010896)4.32831605
15ether lipid metabolic process (GO:0046485)4.25076251
16regulation of germinal center formation (GO:0002634)4.21311643
17dicarboxylic acid biosynthetic process (GO:0043650)4.01091938
18negative regulation of heart rate (GO:0010459)3.91526724
19one-carbon compound transport (GO:0019755)3.85242069
20platelet dense granule organization (GO:0060155)3.77298944
21respiratory chain complex IV assembly (GO:0008535)3.77231688
22GPI anchor metabolic process (GO:0006505)3.75503943
23negative regulation of JUN kinase activity (GO:0043508)3.73905421
24regulation of sarcomere organization (GO:0060297)3.69616400
25regulation of hexokinase activity (GO:1903299)3.66165827
26regulation of glucokinase activity (GO:0033131)3.66165827
27positive regulation of protein homodimerization activity (GO:0090073)3.65823708
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63862989
29branched-chain amino acid catabolic process (GO:0009083)3.63081952
30reverse cholesterol transport (GO:0043691)3.62347099
31regulation of cardiac muscle hypertrophy (GO:0010611)3.52667696
32protein prenylation (GO:0018342)3.52452298
33prenylation (GO:0097354)3.52452298
34transepithelial transport (GO:0070633)3.49738219
35regulation of alkaline phosphatase activity (GO:0010692)3.48464501
36negative regulation of mast cell activation (GO:0033004)3.40592019
37regulation of muscle hypertrophy (GO:0014743)3.37779400
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.37156530
39glycerol ether metabolic process (GO:0006662)3.32625475
40phagocytosis, engulfment (GO:0006911)3.30225013
41plasma lipoprotein particle assembly (GO:0034377)3.30150571
42phospholipid homeostasis (GO:0055091)3.29986760
43protein localization to cilium (GO:0061512)3.23293030
44high-density lipoprotein particle remodeling (GO:0034375)3.22896512
45inositol phosphate dephosphorylation (GO:0046855)3.21093012
46phosphorylated carbohydrate dephosphorylation (GO:0046838)3.21093012
47GPI anchor biosynthetic process (GO:0006506)3.20692354
48branched-chain amino acid metabolic process (GO:0009081)3.18470878
49regulation of cholesterol esterification (GO:0010872)3.17478427
50response to hydroperoxide (GO:0033194)3.13890237
51neutrophil activation involved in immune response (GO:0002283)3.11791682
52valine metabolic process (GO:0006573)3.10793062
53lysine metabolic process (GO:0006553)3.10584755
54lysine catabolic process (GO:0006554)3.10584755
55Golgi to endosome transport (GO:0006895)3.09967496
56ether metabolic process (GO:0018904)3.04800473
57regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03095758
58xenobiotic catabolic process (GO:0042178)3.02059940
59detection of light stimulus involved in sensory perception (GO:0050962)2.99418239
60detection of light stimulus involved in visual perception (GO:0050908)2.99418239
61cellular response to calcium ion (GO:0071277)2.98186681
62inositol phosphate catabolic process (GO:0071545)2.95390575
63mast cell activation involved in immune response (GO:0002279)2.92599914
64mast cell degranulation (GO:0043303)2.92599914
65cytochrome complex assembly (GO:0017004)2.90821927
66regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88452302
67negative regulation of neurotransmitter secretion (GO:0046929)2.87390890
68C-terminal protein lipidation (GO:0006501)2.77269063
69regulation of muscle adaptation (GO:0043502)2.75899209
70mast cell activation (GO:0045576)2.75553206
71interferon-gamma-mediated signaling pathway (GO:0060333)2.73650509
72neural tube formation (GO:0001841)2.72915875
73aspartate family amino acid catabolic process (GO:0009068)2.70387158
74dentate gyrus development (GO:0021542)2.68935621
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68304875
76cardiac conduction (GO:0061337)2.64084691
77protein-lipid complex assembly (GO:0065005)2.63566487
78positive regulation of steroid hormone secretion (GO:2000833)2.63108039
79positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.60876907
80positive regulation of histone H3-K4 methylation (GO:0051571)2.60603765
81centriole replication (GO:0007099)2.60431767
82B cell receptor signaling pathway (GO:0050853)2.60160310
83indolalkylamine metabolic process (GO:0006586)2.59972196
84mature B cell differentiation involved in immune response (GO:0002313)2.59081674
85indole-containing compound catabolic process (GO:0042436)2.58720766
86indolalkylamine catabolic process (GO:0046218)2.58720766
87tryptophan catabolic process (GO:0006569)2.58720766
88positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.58186496
89regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.57614333
90positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.57614333
91positive regulation of phosphatase activity (GO:0010922)2.57131758
92regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57049258
93fucose metabolic process (GO:0006004)2.53724612
94positive regulation of protein autophosphorylation (GO:0031954)2.51968078
95negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51318666
96regulation of fibroblast migration (GO:0010762)2.51159839
97regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.50993713
98positive regulation of mRNA catabolic process (GO:0061014)2.49392169
99C-terminal protein amino acid modification (GO:0018410)2.48923572
100response to pheromone (GO:0019236)11.1091520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human2.73336527
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69603515
3VDR_22108803_ChIP-Seq_LS180_Human2.58516956
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56695732
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30026211
6AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27277236
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.27105666
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26132585
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.24918960
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20984855
11P300_19829295_ChIP-Seq_ESCs_Human2.05764836
12ER_23166858_ChIP-Seq_MCF-7_Human1.99949597
13ELK1_19687146_ChIP-ChIP_HELA_Human1.96396727
14GBX2_23144817_ChIP-Seq_PC3_Human1.95734872
15NANOG_19829295_ChIP-Seq_ESCs_Human1.92599913
16SOX2_19829295_ChIP-Seq_ESCs_Human1.92599913
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90363935
18ZNF274_21170338_ChIP-Seq_K562_Hela1.89915224
19FUS_26573619_Chip-Seq_HEK293_Human1.87228200
20BCAT_22108803_ChIP-Seq_LS180_Human1.78444876
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72482582
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72482582
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72016646
24EWS_26573619_Chip-Seq_HEK293_Human1.70101383
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68520254
26IRF1_19129219_ChIP-ChIP_H3396_Human1.63524250
27FOXA1_21572438_ChIP-Seq_LNCaP_Human1.62602715
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.61237808
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60096164
30TAF15_26573619_Chip-Seq_HEK293_Human1.55577752
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.53484150
32CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50355978
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50053714
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50012903
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49393127
36CBP_20019798_ChIP-Seq_JUKART_Human1.49393127
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.46900548
38PRDM14_20953172_ChIP-Seq_ESCs_Human1.42028256
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41338465
40SALL4_22934838_ChIP-ChIP_CD34+_Human1.40681265
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39309742
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.38776413
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.38301522
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37958022
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37789745
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34817442
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.33765241
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.33057849
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33057849
50AR_25329375_ChIP-Seq_VCAP_Human1.32815996
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31512140
52STAT3_23295773_ChIP-Seq_U87_Human1.30618144
53CDX2_22108803_ChIP-Seq_LS180_Human1.30466742
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.29675634
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28053793
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26736561
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26483020
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25224931
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.24619181
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24537541
61P53_22387025_ChIP-Seq_ESCs_Mouse1.24322189
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23572924
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22933881
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22781762
65RBPJ_21746931_ChIP-Seq_IB4_Human1.22585825
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21585010
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21503637
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21046062
69TP53_22573176_ChIP-Seq_HFKS_Human1.20890111
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20333993
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19963968
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19715639
73P300_18555785_Chip-Seq_ESCs_Mouse1.19519483
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.19323489
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19323459
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18706523
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18490769
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18190877
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18186928
80TCF4_22108803_ChIP-Seq_LS180_Human1.16743643
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.16380907
82NFYB_21822215_ChIP-Seq_K562_Human1.15904092
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14717382
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.13987351
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13708719
86AR_21572438_ChIP-Seq_LNCaP_Human1.13515424
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12890873
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.12190142
89VDR_24787735_ChIP-Seq_THP-1_Human1.11463786
90TCF4_23295773_ChIP-Seq_U87_Human1.11339710
91NCOR_22424771_ChIP-Seq_293T_Human1.11256030
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10385273
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.10355863
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10229902
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.10054686
96GATA6_21074721_ChIP-Seq_CACO-2_Human1.09926713
97PHF8_20622853_ChIP-Seq_HELA_Human1.09612710
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.08480334
99FOXH1_21741376_ChIP-Seq_EPCs_Human1.06344989
100GATA3_26560356_Chip-Seq_TH2_Human1.05331305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.41756525
2MP0003880_abnormal_central_pattern3.97921532
3MP0008877_abnormal_DNA_methylation3.89208684
4MP0002166_altered_tumor_susceptibility3.53784347
5MP0005075_abnormal_melanosome_morpholog3.50788443
6MP0003724_increased_susceptibility_to3.37040483
7MP0008995_early_reproductive_senescence3.01587428
8MP0008057_abnormal_DNA_replication2.92380208
9MP0003191_abnormal_cellular_cholesterol2.89535787
10MP0002006_tumorigenesis2.61147843
11MP0002396_abnormal_hematopoietic_system2.50209784
12MP0005084_abnormal_gallbladder_morpholo2.50006578
13MP0006292_abnormal_olfactory_placode2.33118904
14MP0002009_preneoplasia2.30463116
15MP0005464_abnormal_platelet_physiology2.05318118
16MP0005174_abnormal_tail_pigmentation2.03359270
17MP0001873_stomach_inflammation1.99996338
18MP0001986_abnormal_taste_sensitivity1.98677331
19MP0000613_abnormal_salivary_gland1.98214333
20MP0005397_hematopoietic_system_phenotyp1.95979729
21MP0001545_abnormal_hematopoietic_system1.95979729
22MP0008961_abnormal_basal_metabolism1.94297330
23MP0006054_spinal_hemorrhage1.91028932
24MP0003122_maternal_imprinting1.88993831
25MP0008875_abnormal_xenobiotic_pharmacok1.83076938
26MP0005166_decreased_susceptibility_to1.66045495
27MP0009379_abnormal_foot_pigmentation1.60193860
28MP0004043_abnormal_pH_regulation1.49394795
29MP0003787_abnormal_imprinting1.49074504
30MP0001984_abnormal_olfaction1.46849636
31MP0000516_abnormal_urinary_system1.45286877
32MP0005367_renal/urinary_system_phenotyp1.45286877
33MP0005646_abnormal_pituitary_gland1.45143089
34MP0003195_calcinosis1.45125820
35MP0005647_abnormal_sex_gland1.44216788
36MP0005551_abnormal_eye_electrophysiolog1.42175044
37MP0002876_abnormal_thyroid_physiology1.39295115
38MP0005332_abnormal_amino_acid1.26259646
39MP0004381_abnormal_hair_follicle1.26207577
40MP0005408_hypopigmentation1.24292689
41MP0005423_abnormal_somatic_nervous1.23959597
42MP0005085_abnormal_gallbladder_physiolo1.23805581
43MP0004484_altered_response_of1.23201826
44MP0000371_diluted_coat_color1.21389418
45MP0005671_abnormal_response_to1.20106513
46MP0005310_abnormal_salivary_gland1.17892237
47MP0009785_altered_susceptibility_to1.16903267
48MP0003303_peritoneal_inflammation1.14464621
49MP0001485_abnormal_pinna_reflex1.12280176
50MP0008058_abnormal_DNA_repair1.11153490
51MP0005636_abnormal_mineral_homeostasis1.09782836
52MP0001501_abnormal_sleep_pattern1.09723305
53MP0004885_abnormal_endolymph1.09394939
54MP0001188_hyperpigmentation1.09034118
55MP0002938_white_spotting1.05177378
56MP0001853_heart_inflammation1.04926050
57MP0000372_irregular_coat_pigmentation1.02792364
58MP0005187_abnormal_penis_morphology1.01942857
59MP0005253_abnormal_eye_physiology1.00597367
60MP0002160_abnormal_reproductive_system0.99278629
61MP0006072_abnormal_retinal_apoptosis0.98708966
62MP0001764_abnormal_homeostasis0.94821111
63MP0000015_abnormal_ear_pigmentation0.94294937
64MP0001800_abnormal_humoral_immune0.91270570
65MP0003656_abnormal_erythrocyte_physiolo0.91041456
66MP0001661_extended_life_span0.88508907
67MP0001664_abnormal_digestion0.87562984
68MP0005389_reproductive_system_phenotype0.87042541
69MP0005645_abnormal_hypothalamus_physiol0.86917503
70MP0000569_abnormal_digit_pigmentation0.85693904
71MP0009643_abnormal_urine_homeostasis0.83274931
72MP0002148_abnormal_hypersensitivity_rea0.82638751
73MP0005365_abnormal_bile_salt0.81325438
74MP0003121_genomic_imprinting0.81127329
75MP0000639_abnormal_adrenal_gland0.80216587
76MP0005000_abnormal_immune_tolerance0.78882146
77MP0003868_abnormal_feces_composition0.77889877
78MP0004883_abnormal_blood_vessel0.77692802
79MP0003183_abnormal_peptide_metabolism0.75835984
80MP0001119_abnormal_female_reproductive0.75256867
81MP0000538_abnormal_urinary_bladder0.74805523
82MP0009840_abnormal_foam_cell0.74457817
83MP0004134_abnormal_chest_morphology0.74384235
84MP0009333_abnormal_splenocyte_physiolog0.70621557
85MP0002095_abnormal_skin_pigmentation0.70101506
86MP0000653_abnormal_sex_gland0.69771366
87MP0003937_abnormal_limbs/digits/tail_de0.68448256
88MP0001845_abnormal_inflammatory_respons0.66886880
89MP0001666_abnormal_nutrient_absorption0.64571587
90MP0001756_abnormal_urination0.64190977
91MP0001324_abnormal_eye_pigmentation0.64149802
92MP0002138_abnormal_hepatobiliary_system0.62865406
93MP0003718_maternal_effect0.60414705
94MP0002277_abnormal_respiratory_mucosa0.60289577
95MP0002723_abnormal_immune_serum0.59278319
96MP0002136_abnormal_kidney_physiology0.59183628
97MP0008872_abnormal_physiological_respon0.56736842
98MP0002452_abnormal_antigen_presenting0.56317697
99MP0003786_premature_aging0.56205233
100MP0010386_abnormal_urinary_bladder0.55108784

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.63116593
2Flat capital femoral epiphysis (HP:0003370)4.47606602
3Spontaneous abortion (HP:0005268)4.45889254
4Abnormal rod and cone electroretinograms (HP:0008323)3.83324657
5Hypothermia (HP:0002045)3.76980277
6Metaphyseal dysplasia (HP:0100255)3.63456058
7Pancreatic fibrosis (HP:0100732)3.62473752
8True hermaphroditism (HP:0010459)3.60650934
9Ectropion (HP:0000656)3.47744374
10Tubulointerstitial nephritis (HP:0001970)3.40464117
11Abnormality of the nasal septum (HP:0000419)3.31136610
12Acute lymphatic leukemia (HP:0006721)3.29296399
13Attenuation of retinal blood vessels (HP:0007843)3.25423046
14Facial diplegia (HP:0001349)3.10377757
15Pancreatic cysts (HP:0001737)3.10292848
16Subcapsular cataract (HP:0000523)3.02926661
17Chromsome breakage (HP:0040012)3.01808212
18Hypoalphalipoproteinemia (HP:0003233)3.01358138
19Gonadal dysgenesis (HP:0000133)2.92649420
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92342131
21Abnormality of alanine metabolism (HP:0010916)2.92342131
22Hyperalaninemia (HP:0003348)2.92342131
23Clubbing of toes (HP:0100760)2.89458276
24Hypolipoproteinemia (HP:0010981)2.85831822
25Delayed CNS myelination (HP:0002188)2.80384796
26Disinhibition (HP:0000734)2.76643498
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.76393872
28Alveolar cell carcinoma (HP:0006519)2.76365689
29Nephronophthisis (HP:0000090)2.72008237
30Renal cortical cysts (HP:0000803)2.68280322
31Neoplasm of the tracheobronchial system (HP:0100552)2.66969286
32Abnormal hair whorl (HP:0010721)2.61126428
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.60009903
34Cerebellar dysplasia (HP:0007033)2.57341180
35Microretrognathia (HP:0000308)2.56856257
36Hepatic necrosis (HP:0002605)2.49384491
37Short tibia (HP:0005736)2.47765920
38Stomach cancer (HP:0012126)2.45632709
39Choroideremia (HP:0001139)2.44248140
40Constricted visual fields (HP:0001133)2.42938600
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42356454
42Medial flaring of the eyebrow (HP:0010747)2.37916106
43Hepatocellular necrosis (HP:0001404)2.36217166
44Gaze-evoked nystagmus (HP:0000640)2.35783068
45Submucous cleft hard palate (HP:0000176)2.32574163
46Chronic sinusitis (HP:0011109)2.31738469
47Hypobetalipoproteinemia (HP:0003563)2.28822402
48Abnormality of chromosome stability (HP:0003220)2.27618629
49Abnormality of the axillary hair (HP:0100134)2.25689513
50Abnormality of secondary sexual hair (HP:0009888)2.25689513
51Bundle branch block (HP:0011710)2.25138595
52Posterior subcapsular cataract (HP:0007787)2.24184287
53Testicular neoplasm (HP:0010788)2.23904552
54Hyperglycinemia (HP:0002154)2.19567599
55Progressive inability to walk (HP:0002505)2.19564465
56Cystic liver disease (HP:0006706)2.19373958
573-Methylglutaconic aciduria (HP:0003535)2.18014727
58Sex reversal (HP:0012245)2.17913056
59Abnormal sex determination (HP:0012244)2.17913056
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17461920
61Amelogenesis imperfecta (HP:0000705)2.16520567
62Male pseudohermaphroditism (HP:0000037)2.16377018
63Long clavicles (HP:0000890)2.13322956
64Occipital encephalocele (HP:0002085)2.10368958
65Type I transferrin isoform profile (HP:0003642)2.09009556
66Anencephaly (HP:0002323)2.08411184
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.05286185
68Genital tract atresia (HP:0001827)2.05092423
69Follicular hyperkeratosis (HP:0007502)2.02123016
70Hypomagnesemia (HP:0002917)1.99511139
71Congenital primary aphakia (HP:0007707)1.98739058
72Meckel diverticulum (HP:0002245)1.98300384
73Abnormality of dental color (HP:0011073)1.96047469
74Abnormality of the renal medulla (HP:0100957)1.94699618
75Stenosis of the external auditory canal (HP:0000402)1.94591063
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91405963
77Abnormality of the prostate (HP:0008775)1.90895072
78Short middle phalanx of the 5th finger (HP:0004220)1.88572706
79Aqueductal stenosis (HP:0002410)1.86437574
80Chronic hepatic failure (HP:0100626)1.85357046
81Congenital ichthyosiform erythroderma (HP:0007431)1.84047891
82Gait imbalance (HP:0002141)1.82248990
83Glossoptosis (HP:0000162)1.81692319
84Abnormality of the ileum (HP:0001549)1.80792897
85Pigmentary retinal degeneration (HP:0001146)1.79702242
86Absent/shortened dynein arms (HP:0200106)1.79694429
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.79694429
88Hypoproteinemia (HP:0003075)1.78364451
89Abnormality of the preputium (HP:0100587)1.77494075
90Progressive macrocephaly (HP:0004481)1.76825426
91Cone-rod dystrophy (HP:0000548)1.76162685
92Chronic otitis media (HP:0000389)1.75435551
93Dyschromatopsia (HP:0007641)1.74429362
94Clitoromegaly (HP:0000057)1.72995133
95Abnormality of serum amino acid levels (HP:0003112)1.72571044
96Abnormality of male internal genitalia (HP:0000022)1.72468328
97Decreased central vision (HP:0007663)1.72250368
98Increased CSF lactate (HP:0002490)1.69156934
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.66759572
100Abnormality of methionine metabolism (HP:0010901)1.65214250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.99142207
2BMPR24.45227549
3TRIM283.87393629
4TAOK33.77328183
5SIK33.31596340
6NUAK13.13705560
7PDK23.03868119
8ERBB32.96340535
9FRK2.91366393
10STK242.67300239
11CDK192.66626866
12BRSK22.34341118
13GRK12.17694413
14PBK1.78923208
15TEC1.78302166
16TRPM71.64192166
17MAP4K21.64151547
18OXSR11.48702396
19BCKDK1.46245525
20STK31.43192484
21TNK21.34575760
22AKT31.31630688
23WNK11.25237967
24PIK3CG1.14788214
25PAK31.08737325
26INSRR1.06415666
27BRD41.06286372
28CAMK2D1.05706458
29RPS6KB11.01246775
30BTK0.98352486
31PINK10.96856425
32MKNK10.96147633
33MAPK70.96086712
34WNK40.95368005
35MAP3K120.93781965
36HCK0.93174983
37PRKG20.88979102
38RIPK40.85834618
39WEE10.85079995
40PLK20.83535404
41ITK0.83125361
42BRSK10.81771466
43FLT30.81729643
44WNK30.79967754
45BCR0.79919260
46MAPK120.78917354
47DYRK30.77564971
48STK100.76446819
49LATS10.74984573
50MAPKAPK30.74773509
51KIT0.71479847
52FGFR10.69737728
53PHKG10.69456961
54PHKG20.69456961
55MARK30.68479854
56MKNK20.67316085
57PTK2B0.65656828
58EIF2AK20.64477290
59PRKAA20.63611380
60JAK10.63030585
61PRKCQ0.62953040
62MARK20.61497567
63ZAK0.58560582
64PRKCI0.57992788
65STK390.57934228
66PRKCE0.56149730
67IKBKB0.53823222
68NEK60.53267923
69SRPK10.51690574
70TLK10.50449120
71TYK20.49730565
72MINK10.49699474
73STK38L0.49292220
74MAP3K140.44112548
75FES0.43795093
76TNIK0.42900051
77ROCK10.42278350
78LRRK20.40901342
79FER0.38623914
80CSNK1G10.37312807
81EGFR0.36596661
82ADRBK20.35007511
83ABL10.34998865
84CSNK1G20.34489601
85PRKAA10.34411449
86OBSCN0.32464510
87CCNB10.32336334
88CSNK1G30.31845084
89CSF1R0.31615517
90CSNK2A10.31283619
91CSNK1E0.30685398
92MYLK0.30374764
93MAPK130.30033909
94TAOK10.28176540
95TXK0.27204347
96PRKCB0.26893802
97JAK20.26614821
98PLK30.26271551
99CSNK1A1L0.26270259
100IGF1R0.25873669

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.80524611
2Allograft rejection_Homo sapiens_hsa053303.43279573
3Graft-versus-host disease_Homo sapiens_hsa053323.37415405
4Autoimmune thyroid disease_Homo sapiens_hsa053203.22105061
5Type I diabetes mellitus_Homo sapiens_hsa049403.21066996
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84628629
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65706036
8Nitrogen metabolism_Homo sapiens_hsa009102.61927411
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.60965246
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55469259
11Caffeine metabolism_Homo sapiens_hsa002322.38649981
12Staphylococcus aureus infection_Homo sapiens_hsa051502.36990531
13Propanoate metabolism_Homo sapiens_hsa006402.32899327
14Leishmaniasis_Homo sapiens_hsa051402.14720711
15Proteasome_Homo sapiens_hsa030501.99749449
16Olfactory transduction_Homo sapiens_hsa047401.64723364
17Viral myocarditis_Homo sapiens_hsa054161.63624840
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.62384586
19Antigen processing and presentation_Homo sapiens_hsa046121.60842689
20Butanoate metabolism_Homo sapiens_hsa006501.53743489
21Rheumatoid arthritis_Homo sapiens_hsa053231.49630551
22Tryptophan metabolism_Homo sapiens_hsa003801.41929261
23Peroxisome_Homo sapiens_hsa041461.39154503
24One carbon pool by folate_Homo sapiens_hsa006701.33810030
25Phototransduction_Homo sapiens_hsa047441.33013870
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32704509
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20326944
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19756063
29Salivary secretion_Homo sapiens_hsa049701.12884431
30Fatty acid biosynthesis_Homo sapiens_hsa000611.06574555
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01677423
32Circadian entrainment_Homo sapiens_hsa047131.00038833
33Tuberculosis_Homo sapiens_hsa051520.98354983
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98035890
35ABC transporters_Homo sapiens_hsa020100.97715294
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97410021
37Fatty acid degradation_Homo sapiens_hsa000710.94925634
38Fat digestion and absorption_Homo sapiens_hsa049750.94493312
39Steroid hormone biosynthesis_Homo sapiens_hsa001400.93990697
40Vitamin digestion and absorption_Homo sapiens_hsa049770.93978665
41Gastric acid secretion_Homo sapiens_hsa049710.91843341
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88062777
43Circadian rhythm_Homo sapiens_hsa047100.87505438
44Fatty acid elongation_Homo sapiens_hsa000620.85165219
45Toxoplasmosis_Homo sapiens_hsa051450.83540499
46RNA polymerase_Homo sapiens_hsa030200.82769284
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82606891
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82308823
49Fatty acid metabolism_Homo sapiens_hsa012120.80529182
50African trypanosomiasis_Homo sapiens_hsa051430.77438542
51Retinol metabolism_Homo sapiens_hsa008300.74747323
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69526281
53PPAR signaling pathway_Homo sapiens_hsa033200.69352738
54Chemical carcinogenesis_Homo sapiens_hsa052040.68350220
55Renin secretion_Homo sapiens_hsa049240.64536844
56Hematopoietic cell lineage_Homo sapiens_hsa046400.64482477
57Amphetamine addiction_Homo sapiens_hsa050310.62918302
58Linoleic acid metabolism_Homo sapiens_hsa005910.62443210
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60337779
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57698875
61Glucagon signaling pathway_Homo sapiens_hsa049220.57611922
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.57314658
63Pancreatic secretion_Homo sapiens_hsa049720.56945076
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56586284
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55629048
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55612790
67Systemic lupus erythematosus_Homo sapiens_hsa053220.54812942
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54272811
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50197670
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50010082
71Sulfur metabolism_Homo sapiens_hsa009200.48865476
72Collecting duct acid secretion_Homo sapiens_hsa049660.48858348
73Herpes simplex infection_Homo sapiens_hsa051680.48060632
74Glutathione metabolism_Homo sapiens_hsa004800.47528478
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47170896
76Basal transcription factors_Homo sapiens_hsa030220.46956649
77Influenza A_Homo sapiens_hsa051640.45389623
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43856491
79Arginine biosynthesis_Homo sapiens_hsa002200.41921317
80Homologous recombination_Homo sapiens_hsa034400.41318890
81Insulin secretion_Homo sapiens_hsa049110.40376000
82Non-homologous end-joining_Homo sapiens_hsa034500.40052454
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39998319
84RNA degradation_Homo sapiens_hsa030180.38872646
85Legionellosis_Homo sapiens_hsa051340.38633951
86Starch and sucrose metabolism_Homo sapiens_hsa005000.38554013
87beta-Alanine metabolism_Homo sapiens_hsa004100.38203733
88Platelet activation_Homo sapiens_hsa046110.35555517
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34666428
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33225843
91Oxidative phosphorylation_Homo sapiens_hsa001900.30437643
92Fanconi anemia pathway_Homo sapiens_hsa034600.29577625
93Oocyte meiosis_Homo sapiens_hsa041140.29247302
94Long-term potentiation_Homo sapiens_hsa047200.28199027
95Epstein-Barr virus infection_Homo sapiens_hsa051690.23288552
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22932957
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22414766
98Metabolic pathways_Homo sapiens_hsa011000.20506305
99Phagosome_Homo sapiens_hsa041450.20464339
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20244383

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »