FCF1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)7.91737664
2cell wall macromolecule catabolic process (GO:0016998)6.31788823
3C4-dicarboxylate transport (GO:0015740)6.31148404
4positive regulation of macrophage activation (GO:0043032)6.25783196
5regulation of translation in response to stress (GO:0043555)6.21948360
6cell wall macromolecule metabolic process (GO:0044036)5.70327990
7embryonic viscerocranium morphogenesis (GO:0048703)5.20775490
8regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.10337410
9pyrimidine dimer repair (GO:0006290)5.03572088
10negative regulation of cAMP-mediated signaling (GO:0043951)5.01281384
11positive regulation of chemokine secretion (GO:0090197)4.96995764
12response to nitrosative stress (GO:0051409)4.93875049
13neural tube formation (GO:0001841)4.90727823
14ER overload response (GO:0006983)4.84239265
15microtubule nucleation (GO:0007020)4.69021133
16centriole replication (GO:0007099)4.62685597
17histone mRNA catabolic process (GO:0071044)4.55175145
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.51169720
19regulation of chemokine secretion (GO:0090196)4.50522373
20fusion of sperm to egg plasma membrane (GO:0007342)4.46327607
21atrial cardiac muscle cell action potential (GO:0086014)4.41782184
22regulation of meiosis I (GO:0060631)4.18996945
23regulation of immunoglobulin secretion (GO:0051023)4.14686647
24cerebral cortex radially oriented cell migration (GO:0021799)4.10775826
25L-methionine salvage (GO:0071267)3.94582053
26L-methionine biosynthetic process (GO:0071265)3.94582053
27amino acid salvage (GO:0043102)3.94582053
28negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.89771364
29radial glial cell differentiation (GO:0060019)3.83989868
30mitotic sister chromatid cohesion (GO:0007064)3.80563354
31peptidyl-histidine modification (GO:0018202)3.77894506
32otic vesicle formation (GO:0030916)3.77382076
33positive regulation of interleukin-4 production (GO:0032753)3.76829535
34amino-acid betaine metabolic process (GO:0006577)3.76248591
35postsynaptic membrane organization (GO:0001941)3.70723699
36single strand break repair (GO:0000012)3.70338963
37presynaptic membrane assembly (GO:0097105)3.70027599
38regulation of acrosome reaction (GO:0060046)3.67540945
39regulation of smooth muscle cell apoptotic process (GO:0034391)3.65369710
40segment specification (GO:0007379)3.63795071
41monoubiquitinated protein deubiquitination (GO:0035520)3.59923734
42cerebral cortex cell migration (GO:0021795)3.57667760
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55741315
44postreplication repair (GO:0006301)3.53690133
45mechanosensory behavior (GO:0007638)3.53271159
46arginine catabolic process (GO:0006527)3.50493820
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.45563167
48sperm-egg recognition (GO:0035036)3.41855233
49regulation of interleukin-13 production (GO:0032656)3.41841687
50presynaptic membrane organization (GO:0097090)3.37854960
51platelet dense granule organization (GO:0060155)3.37019123
52aldehyde catabolic process (GO:0046185)3.35802284
53secretory granule organization (GO:0033363)3.34180889
54regulation of non-canonical Wnt signaling pathway (GO:2000050)3.33799086
55auditory behavior (GO:0031223)3.32988540
56lysosome localization (GO:0032418)3.31025586
57toxin transport (GO:1901998)3.30619831
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28421297
59cellular response to sterol (GO:0036315)3.27816582
60plasma membrane fusion (GO:0045026)3.26042094
61genitalia morphogenesis (GO:0035112)3.18629875
62response to xenobiotic stimulus (GO:0009410)3.17964173
63regulation of rhodopsin mediated signaling pathway (GO:0022400)3.15650179
64fucose catabolic process (GO:0019317)3.15481827
65L-fucose metabolic process (GO:0042354)3.15481827
66L-fucose catabolic process (GO:0042355)3.15481827
67multicellular organism reproduction (GO:0032504)3.13817675
68regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.11095853
69rhodopsin mediated signaling pathway (GO:0016056)3.06812684
70forebrain neuron differentiation (GO:0021879)3.04179661
71embryonic epithelial tube formation (GO:0001838)3.00615517
72oligodendrocyte development (GO:0014003)2.95957258
73response to UV-C (GO:0010225)2.95623293
74histone mRNA metabolic process (GO:0008334)2.95313063
75response to folic acid (GO:0051593)2.87447267
76benzene-containing compound metabolic process (GO:0042537)2.86152237
77heart valve formation (GO:0003188)2.86092352
78limb bud formation (GO:0060174)2.85161718
79cellular response to cholesterol (GO:0071397)2.84832274
80regulation of mesenchymal cell apoptotic process (GO:2001053)2.83801146
81positive regulation of guanylate cyclase activity (GO:0031284)2.83274547
82retinal cone cell development (GO:0046549)2.82834814
83epithelial tube formation (GO:0072175)2.82628208
84intraciliary transport (GO:0042073)2.81243568
85cell-cell recognition (GO:0009988)2.80819487
86detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.80675398
87centriole assembly (GO:0098534)2.77233991
88detection of light stimulus involved in visual perception (GO:0050908)2.76522578
89detection of light stimulus involved in sensory perception (GO:0050962)2.76522578
90regulation of macrophage activation (GO:0043030)2.75535094
91cell migration involved in gastrulation (GO:0042074)2.75066635
92DNA synthesis involved in DNA repair (GO:0000731)2.74411525
93keratinocyte development (GO:0003334)2.71734351
94nephron tubule formation (GO:0072079)2.68583614
95regulation of chromatin silencing (GO:0031935)2.68352534
96GMP metabolic process (GO:0046037)2.67983257
97replication fork processing (GO:0031297)2.67557944
98negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64292320
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.62965153
100positive regulation of type 2 immune response (GO:0002830)2.62504263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.52759763
2VDR_22108803_ChIP-Seq_LS180_Human3.52522496
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.12223429
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60164399
5GBX2_23144817_ChIP-Seq_PC3_Human2.57771988
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41019175
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38324705
8IRF1_19129219_ChIP-ChIP_H3396_Human2.27590365
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25280043
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.13800857
11MYC_18940864_ChIP-ChIP_HL60_Human2.10375960
12P300_19829295_ChIP-Seq_ESCs_Human1.99228453
13EWS_26573619_Chip-Seq_HEK293_Human1.98125126
14MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.96517887
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89427447
16ER_23166858_ChIP-Seq_MCF-7_Human1.83784498
17SMAD4_21799915_ChIP-Seq_A2780_Human1.79780249
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78257358
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73999872
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72696878
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71165375
22TP53_22573176_ChIP-Seq_HFKS_Human1.70194770
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66162428
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65555252
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64679192
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64679192
27EZH2_22144423_ChIP-Seq_EOC_Human1.63091629
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60446926
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.60226564
30FOXP3_21729870_ChIP-Seq_TREG_Human1.57555630
31KLF5_20875108_ChIP-Seq_MESCs_Mouse1.56971176
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56528314
33TCF4_23295773_ChIP-Seq_U87_Human1.55438976
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54091046
35STAT3_23295773_ChIP-Seq_U87_Human1.53986658
36BCAT_22108803_ChIP-Seq_LS180_Human1.53903675
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45110052
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.44717072
39ELK1_19687146_ChIP-ChIP_HELA_Human1.44268607
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43570701
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42944059
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40716346
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.40105611
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39703713
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38065154
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.37782424
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37678590
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34265126
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33721878
50RUNX2_22187159_ChIP-Seq_PCA_Human1.33428685
51CDX2_22108803_ChIP-Seq_LS180_Human1.33040789
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31922447
53AR_25329375_ChIP-Seq_VCAP_Human1.27528178
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26774898
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26542395
56HOXB7_26014856_ChIP-Seq_BT474_Human1.24627107
57CBP_20019798_ChIP-Seq_JUKART_Human1.24074437
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24074437
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.23794650
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.22009102
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21502761
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19419490
63HTT_18923047_ChIP-ChIP_STHdh_Human1.18706460
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16289105
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.16241126
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15699409
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.15463945
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15401157
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.14609607
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.14356163
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14318959
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.14207870
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.13601846
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13601846
75ETV1_20927104_ChIP-Seq_GIST48_Human1.13437772
76TCF4_22108803_ChIP-Seq_LS180_Human1.13432616
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12848255
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.12306379
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.09658593
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09334102
81SOX2_19829295_ChIP-Seq_ESCs_Human1.08651503
82NANOG_19829295_ChIP-Seq_ESCs_Human1.08651503
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.07785521
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.07764743
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06221467
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05621457
87P53_22387025_ChIP-Seq_ESCs_Mouse1.05576251
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05337545
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04474913
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04230780
91MYC_19829295_ChIP-Seq_ESCs_Human1.02721132
92P53_21459846_ChIP-Seq_SAOS-2_Human1.01731759
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01129768
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00838269
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00010801
96JUN_21703547_ChIP-Seq_K562_Human0.99075751
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.98948663
98FUS_26573619_Chip-Seq_HEK293_Human0.98820122
99P300_18555785_Chip-Seq_ESCs_Mouse0.98536584
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.98070835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology7.30318786
2MP0002653_abnormal_ependyma_morphology4.02217286
3MP0004885_abnormal_endolymph3.40296778
4MP0002254_reproductive_system_inflammat3.15419517
5MP0005377_hearing/vestibular/ear_phenot2.98465019
6MP0003878_abnormal_ear_physiology2.98465019
7MP0000015_abnormal_ear_pigmentation2.97899168
8MP0006292_abnormal_olfactory_placode2.75091885
9MP0003880_abnormal_central_pattern2.69598883
10MP0002736_abnormal_nociception_after2.64883871
11MP0005379_endocrine/exocrine_gland_phen2.47655393
12MP0004742_abnormal_vestibular_system2.34270836
13MP0005551_abnormal_eye_electrophysiolog2.01829136
14MP0002282_abnormal_trachea_morphology1.97547305
15MP0000049_abnormal_middle_ear1.88741130
16MP0003890_abnormal_embryonic-extraembry1.81845526
17MP0001968_abnormal_touch/_nociception1.79829183
18MP0000383_abnormal_hair_follicle1.78564242
19MP0002177_abnormal_outer_ear1.74441743
20MP0003718_maternal_effect1.71112929
21MP0008058_abnormal_DNA_repair1.67851905
22MP0001486_abnormal_startle_reflex1.66198176
23MP0003646_muscle_fatigue1.59771588
24MP0008875_abnormal_xenobiotic_pharmacok1.49658058
25MP0002837_dystrophic_cardiac_calcinosis1.47391517
26MP0002095_abnormal_skin_pigmentation1.46285911
27MP0006035_abnormal_mitochondrial_morpho1.45691168
28MP0002132_abnormal_respiratory_system1.43042785
29MP0006276_abnormal_autonomic_nervous1.35347724
30MP0002234_abnormal_pharynx_morphology1.34784958
31MP0008789_abnormal_olfactory_epithelium1.33782340
32MP0001984_abnormal_olfaction1.33558519
33MP0001293_anophthalmia1.31513766
34MP0000569_abnormal_digit_pigmentation1.30100969
35MP0005253_abnormal_eye_physiology1.30076478
36MP0000026_abnormal_inner_ear1.29226050
37MP0004215_abnormal_myocardial_fiber1.21964270
38MP0003195_calcinosis1.18309036
39MP0002735_abnormal_chemical_nociception1.17015861
40MP0000762_abnormal_tongue_morphology1.15499700
41MP0002557_abnormal_social/conspecific_i1.15019433
42MP0001270_distended_abdomen1.14916420
43MP0001485_abnormal_pinna_reflex1.14138200
44MP0002098_abnormal_vibrissa_morphology1.13041395
45MP0003950_abnormal_plasma_membrane1.12866236
46MP0008872_abnormal_physiological_respon1.12245035
47MP0000778_abnormal_nervous_system1.10665524
48MP0005195_abnormal_posterior_eye1.09748557
49MP0005386_behavior/neurological_phenoty1.08481489
50MP0004924_abnormal_behavior1.08481489
51MP0006072_abnormal_retinal_apoptosis1.06537669
52MP0000631_abnormal_neuroendocrine_gland1.06371266
53MP0000647_abnormal_sebaceous_gland1.05813714
54MP0001529_abnormal_vocalization1.03755743
55MP0000427_abnormal_hair_cycle1.03647183
56MP0002752_abnormal_somatic_nervous1.02552371
57MP0008569_lethality_at_weaning1.01341992
58MP0000750_abnormal_muscle_regeneration1.01268403
59MP0008877_abnormal_DNA_methylation1.00727974
60MP0009764_decreased_sensitivity_to0.98958187
61MP0004043_abnormal_pH_regulation0.98644383
62MP0003632_abnormal_nervous_system0.98611072
63MP0010678_abnormal_skin_adnexa0.98004715
64MP0004811_abnormal_neuron_physiology0.95964891
65MP0003635_abnormal_synaptic_transmissio0.94925094
66MP0003755_abnormal_palate_morphology0.94812646
67MP0005410_abnormal_fertilization0.93752675
68MP0008775_abnormal_heart_ventricle0.93573690
69MP0008057_abnormal_DNA_replication0.93055670
70MP0005395_other_phenotype0.92712821
71MP0003698_abnormal_male_reproductive0.91936651
72MP0005391_vision/eye_phenotype0.88077266
73MP0004133_heterotaxia0.85099637
74MP0009745_abnormal_behavioral_response0.84441270
75MP0005394_taste/olfaction_phenotype0.83886170
76MP0005499_abnormal_olfactory_system0.83886170
77MP0001348_abnormal_lacrimal_gland0.83526284
78MP0000613_abnormal_salivary_gland0.83349523
79MP0002063_abnormal_learning/memory/cond0.82665281
80MP0002572_abnormal_emotion/affect_behav0.82075089
81MP0003861_abnormal_nervous_system0.81440511
82MP0003935_abnormal_craniofacial_develop0.79982457
83MP0000428_abnormal_craniofacial_morphol0.79442215
84MP0004147_increased_porphyrin_level0.78647641
85MP0001727_abnormal_embryo_implantation0.77618283
86MP0000678_abnormal_parathyroid_gland0.76529143
87MP0002928_abnormal_bile_duct0.75734907
88MP0006054_spinal_hemorrhage0.75065049
89MP0003806_abnormal_nucleotide_metabolis0.74971086
90MP0005187_abnormal_penis_morphology0.74871181
91MP0001324_abnormal_eye_pigmentation0.73681474
92MP0005365_abnormal_bile_salt0.72436249
93MP0002751_abnormal_autonomic_nervous0.71054240
94MP0001970_abnormal_pain_threshold0.71043928
95MP0006036_abnormal_mitochondrial_physio0.70794877
96MP0001440_abnormal_grooming_behavior0.70562661
97MP0001986_abnormal_taste_sensitivity0.70442947
98MP0001963_abnormal_hearing_physiology0.70203965
99MP0002882_abnormal_neuron_morphology0.67194453
100MP0003937_abnormal_limbs/digits/tail_de0.66704644

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)5.07194669
2Abnormality of the renal cortex (HP:0011035)4.23900465
3Hip dysplasia (HP:0001385)3.96788151
4Abnormality of the nasal septum (HP:0000419)3.91831218
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.85826175
6True hermaphroditism (HP:0010459)3.59117205
7Oligodactyly (hands) (HP:0001180)3.51570774
811 pairs of ribs (HP:0000878)3.49741706
9Abnormal rod and cone electroretinograms (HP:0008323)3.49577200
10Mixed hearing impairment (HP:0000410)3.41799571
11Abnormality of the renal medulla (HP:0100957)3.41282087
12Vitreoretinal degeneration (HP:0000655)3.40207211
13Nephrogenic diabetes insipidus (HP:0009806)3.39939429
14Entropion (HP:0000621)3.39028231
15Volvulus (HP:0002580)3.35171685
16Tubulointerstitial fibrosis (HP:0005576)3.27477959
17Rectal prolapse (HP:0002035)3.21360416
18Molar tooth sign on MRI (HP:0002419)3.17356366
19Abnormality of midbrain morphology (HP:0002418)3.17356366
20Congenital stationary night blindness (HP:0007642)3.15778518
21Tubulointerstitial abnormality (HP:0001969)3.09926027
22Oligodactyly (HP:0012165)3.05531558
23Fibular hypoplasia (HP:0003038)2.98869245
24Poor eye contact (HP:0000817)2.95092597
25Abnormal gallbladder physiology (HP:0012438)2.90408920
26Cholecystitis (HP:0001082)2.90408920
27Metabolic alkalosis (HP:0200114)2.79587347
28Attenuation of retinal blood vessels (HP:0007843)2.78350994
29Hypokalemic alkalosis (HP:0001949)2.74651479
30Focal motor seizures (HP:0011153)2.71881315
31Chronic bronchitis (HP:0004469)2.71806619
32Pancreatic cysts (HP:0001737)2.70077019
33Pancreatic fibrosis (HP:0100732)2.66050131
34Irregular epiphyses (HP:0010582)2.65694879
35Cutaneous melanoma (HP:0012056)2.60453535
36Methylmalonic acidemia (HP:0002912)2.59803300
37Lissencephaly (HP:0001339)2.58910214
38Long clavicles (HP:0000890)2.54192987
39Cerebral hypomyelination (HP:0006808)2.50564709
40Nephronophthisis (HP:0000090)2.47078452
41Poikiloderma (HP:0001029)2.45067365
42Abnormality of the parathyroid morphology (HP:0011766)2.42988770
43Microtia (HP:0008551)2.41084101
44Tubulointerstitial nephritis (HP:0001970)2.41040494
45Thickened calvaria (HP:0002684)2.38150232
46Abnormality of the right ventricle (HP:0001707)2.38034188
47Neonatal respiratory distress (HP:0002643)2.31589388
48Stenosis of the external auditory canal (HP:0000402)2.27778966
49Hyperaldosteronism (HP:0000859)2.25857807
50Pendular nystagmus (HP:0012043)2.25717905
51Morphological abnormality of the inner ear (HP:0011390)2.25498413
52Renal cortical cysts (HP:0000803)2.24371252
53Small hand (HP:0200055)2.23835261
54Hyperventilation (HP:0002883)2.22009246
55Impaired social interactions (HP:0000735)2.20223355
56Abnormal social behavior (HP:0012433)2.20223355
57Widely spaced teeth (HP:0000687)2.20074559
58Polyuria (HP:0000103)2.19342090
59Hypoplastic iliac wings (HP:0002866)2.11174446
60Blepharitis (HP:0000498)2.08989615
61Delusions (HP:0000746)2.08669480
62Increased corneal curvature (HP:0100692)2.07540451
63Keratoconus (HP:0000563)2.07540451
64Constricted visual fields (HP:0001133)2.03323051
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01550587
66Short 4th metacarpal (HP:0010044)2.01550587
67Progressive inability to walk (HP:0002505)1.99984372
68Tented upper lip vermilion (HP:0010804)1.99181854
69Renal salt wasting (HP:0000127)1.99113709
70Atonic seizures (HP:0010819)1.97532235
71Methylmalonic aciduria (HP:0012120)1.96077074
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.94608177
73Cystic liver disease (HP:0006706)1.92585069
74Adrenal hypoplasia (HP:0000835)1.92177726
75Tubular atrophy (HP:0000092)1.90100520
76Furrowed tongue (HP:0000221)1.88575955
77Hepatocellular necrosis (HP:0001404)1.87775832
78Medial flaring of the eyebrow (HP:0010747)1.82789790
79Acute necrotizing encephalopathy (HP:0006965)1.82478193
80Renal tubular acidosis (HP:0001947)1.81638905
81Drooling (HP:0002307)1.81373911
82Hypoplastic ischia (HP:0003175)1.80067825
83Morphological abnormality of the middle ear (HP:0008609)1.79386612
84Abnormality of the metopic suture (HP:0005556)1.79331329
85Sloping forehead (HP:0000340)1.79232159
86Optic disc pallor (HP:0000543)1.78661754
87Hypoplastic ilia (HP:0000946)1.77665703
88Febrile seizures (HP:0002373)1.74573376
89Short chin (HP:0000331)1.74310761
90Highly arched eyebrow (HP:0002553)1.74270667
91Broad-based gait (HP:0002136)1.74211554
92Facial diplegia (HP:0001349)1.73545604
93Astigmatism (HP:0000483)1.72896814
94Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72083901
95Vertebral hypoplasia (HP:0008417)1.72083901
96Abnormality of the aortic arch (HP:0012303)1.71601725
97Abnormal urine output (HP:0012590)1.71585071
98Large hands (HP:0001176)1.68830550
99Abnormality of the ischium (HP:0003174)1.68768557
100Abnormality of the 4th metacarpal (HP:0010012)1.68553557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.49803538
2NUAK16.87261028
3BRD44.36633154
4MARK12.62888101
5WNK32.33827483
6STK32.33699937
7EIF2AK12.16423322
8ADRBK22.10363586
9ERBB31.84034275
10CDK31.83549348
11PDK21.74327917
12FRK1.69445701
13MAP3K31.62358416
14PNCK1.56500766
15FGFR31.51437901
16CSNK1G11.46933228
17INSRR1.43324589
18BMPR1B1.36241541
19TAOK11.33821795
20MAPK121.32427670
21NEK11.28361642
22PLK21.13855990
23ACVR1B1.12983118
24PTK2B1.11552102
25MAPK131.09536430
26EPHA41.06750777
27MAP2K31.06196897
28NEK61.04741594
29MKNK21.00611850
30FGFR10.96374490
31EPHB20.95265779
32TAOK20.92978684
33TNIK0.90637686
34MAP2K60.90232535
35CDC70.89416812
36PRKCQ0.88624571
37SIK20.85086590
38CAMK1G0.84028401
39PLK40.83017599
40PAK30.82869702
41FER0.78306708
42MATK0.78163149
43TEC0.71886765
44CCNB10.71818293
45VRK10.71652854
46VRK20.70602701
47MARK30.70473397
48NLK0.69695242
49UHMK10.69304040
50MKNK10.69173627
51TGFBR10.69134152
52ERBB40.67177032
53DAPK20.65378322
54STK160.65009307
55ADRBK10.63287843
56GRK70.62675344
57SGK20.61113140
58WEE10.59912549
59BUB10.56713447
60OXSR10.56295416
61STK390.52966446
62PRKG10.52301317
63EGFR0.51101210
64PLK10.50981922
65PRKCE0.50837087
66SMG10.50516099
67PLK30.48684507
68GRK10.48422418
69PINK10.45170726
70MAP2K20.42142275
71NEK20.40177743
72STK110.38893912
73ATM0.38466171
74GSK3A0.38132380
75MST40.34988986
76ATR0.34765956
77PHKG10.33342132
78PHKG20.33342132
79RPS6KB10.33157025
80CDK70.33117554
81CSNK1G30.32783847
82STK100.32247856
83ROCK10.32186164
84PKN10.32026196
85PRKCG0.31080413
86CSNK1E0.29912489
87CAMK1D0.28561099
88TAF10.28232323
89CLK10.27573157
90ERBB20.27551091
91IGF1R0.27185524
92MAPK140.26170362
93NME20.25507642
94PRKACA0.24017073
95CSNK1A1L0.23766154
96ZAK0.22651875
97PRKCI0.22495780
98SGK4940.20932305
99SGK2230.20932305
100CAMK10.20525131

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.20949985
2Phototransduction_Homo sapiens_hsa047443.86616797
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.79055478
4Taste transduction_Homo sapiens_hsa047422.72855138
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69921999
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54842685
7Linoleic acid metabolism_Homo sapiens_hsa005912.50997692
8Fanconi anemia pathway_Homo sapiens_hsa034602.35463914
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30862844
10Nitrogen metabolism_Homo sapiens_hsa009102.25364432
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10334789
12Propanoate metabolism_Homo sapiens_hsa006401.99304939
13Proteasome_Homo sapiens_hsa030501.98121923
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.89725416
15Selenocompound metabolism_Homo sapiens_hsa004501.75348579
16Ether lipid metabolism_Homo sapiens_hsa005651.75151272
17Basal transcription factors_Homo sapiens_hsa030221.75073259
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72200071
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.67469159
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66394212
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63003777
22Butanoate metabolism_Homo sapiens_hsa006501.59082324
23RNA transport_Homo sapiens_hsa030131.54171151
24Glutathione metabolism_Homo sapiens_hsa004801.53011874
25Protein export_Homo sapiens_hsa030601.51915439
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40195820
27Caffeine metabolism_Homo sapiens_hsa002321.38951722
28Chemical carcinogenesis_Homo sapiens_hsa052041.38529159
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38377007
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37391242
31Serotonergic synapse_Homo sapiens_hsa047261.35958593
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34932338
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.33868377
34Olfactory transduction_Homo sapiens_hsa047401.30513598
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22430362
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20506553
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18907065
38mRNA surveillance pathway_Homo sapiens_hsa030151.14983610
39Collecting duct acid secretion_Homo sapiens_hsa049661.13668740
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10202995
41Retinol metabolism_Homo sapiens_hsa008300.97974467
42Hedgehog signaling pathway_Homo sapiens_hsa043400.95375588
43Base excision repair_Homo sapiens_hsa034100.94962592
44Mineral absorption_Homo sapiens_hsa049780.91652380
45Inositol phosphate metabolism_Homo sapiens_hsa005620.90486349
46Non-homologous end-joining_Homo sapiens_hsa034500.90039050
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89017549
48Glutamatergic synapse_Homo sapiens_hsa047240.87128905
49Arachidonic acid metabolism_Homo sapiens_hsa005900.85573019
50Basal cell carcinoma_Homo sapiens_hsa052170.83201636
51One carbon pool by folate_Homo sapiens_hsa006700.82544267
52Long-term depression_Homo sapiens_hsa047300.78192152
53Nicotine addiction_Homo sapiens_hsa050330.77956196
54Ovarian steroidogenesis_Homo sapiens_hsa049130.75954606
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74453986
56Tryptophan metabolism_Homo sapiens_hsa003800.71022548
57Oxidative phosphorylation_Homo sapiens_hsa001900.69322205
58Axon guidance_Homo sapiens_hsa043600.69225012
59N-Glycan biosynthesis_Homo sapiens_hsa005100.67410021
60Glycerolipid metabolism_Homo sapiens_hsa005610.65295825
61Parkinsons disease_Homo sapiens_hsa050120.62892300
62beta-Alanine metabolism_Homo sapiens_hsa004100.61906102
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61729516
64RNA polymerase_Homo sapiens_hsa030200.61160411
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59031336
66Peroxisome_Homo sapiens_hsa041460.57446600
67Oocyte meiosis_Homo sapiens_hsa041140.57072717
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53913058
69p53 signaling pathway_Homo sapiens_hsa041150.53825033
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51815443
71Salivary secretion_Homo sapiens_hsa049700.51634921
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.50245774
73Fat digestion and absorption_Homo sapiens_hsa049750.49994560
74Carbon metabolism_Homo sapiens_hsa012000.49799129
75Metabolic pathways_Homo sapiens_hsa011000.48420049
76ABC transporters_Homo sapiens_hsa020100.46501116
77Huntingtons disease_Homo sapiens_hsa050160.45097881
78Homologous recombination_Homo sapiens_hsa034400.43099473
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42044520
80Tyrosine metabolism_Homo sapiens_hsa003500.41272445
81Wnt signaling pathway_Homo sapiens_hsa043100.41037032
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39895619
83Fatty acid elongation_Homo sapiens_hsa000620.38826644
84Alzheimers disease_Homo sapiens_hsa050100.38241556
85Circadian entrainment_Homo sapiens_hsa047130.36773295
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36456449
87Hippo signaling pathway_Homo sapiens_hsa043900.34404270
88Dopaminergic synapse_Homo sapiens_hsa047280.33468131
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33182033
90Arginine and proline metabolism_Homo sapiens_hsa003300.33032277
91Fatty acid metabolism_Homo sapiens_hsa012120.31805997
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31477183
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31348179
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31135299
95TGF-beta signaling pathway_Homo sapiens_hsa043500.30214945
96Morphine addiction_Homo sapiens_hsa050320.29350491
97Histidine metabolism_Homo sapiens_hsa003400.28936874
98Legionellosis_Homo sapiens_hsa051340.28323312
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26134593
100Pyrimidine metabolism_Homo sapiens_hsa002400.25937487

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