FCGR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.30689245
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.30689245
3modulation by symbiont of host immune response (GO:0052553)6.30689245
4positive regulation by symbiont of host defense response (GO:0052509)6.30689245
5modulation by symbiont of host defense response (GO:0052031)6.30689245
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.30689245
7positive regulation of gamma-delta T cell activation (GO:0046645)5.56997838
8detection of molecule of bacterial origin (GO:0032490)5.55730766
9macrophage activation involved in immune response (GO:0002281)5.50374982
10negative regulation of cell killing (GO:0031342)5.44819272
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44819272
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22674577
13neutrophil activation involved in immune response (GO:0002283)5.16826565
14microglial cell activation (GO:0001774)5.16553226
15response to peptidoglycan (GO:0032494)5.05290828
16negative regulation of interleukin-12 production (GO:0032695)4.97045550
17detection of other organism (GO:0098543)4.95819594
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.82554447
19detection of external biotic stimulus (GO:0098581)4.78677818
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69444857
21antigen processing and presentation of endogenous antigen (GO:0019883)4.53774823
22immunoglobulin mediated immune response (GO:0016064)4.52979184
23detection of bacterium (GO:0016045)4.50391716
24regulation of interferon-beta biosynthetic process (GO:0045357)4.47308529
25macrophage activation (GO:0042116)4.34441244
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31450344
27response to host immune response (GO:0052572)4.29452345
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.29452345
29regulation of B cell receptor signaling pathway (GO:0050855)4.28810245
30cellular extravasation (GO:0045123)4.23904482
31detection of biotic stimulus (GO:0009595)4.23416931
32regulation of gamma-delta T cell activation (GO:0046643)4.05122618
33leukocyte aggregation (GO:0070486)3.94723964
34positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.94541526
35neutrophil activation (GO:0042119)3.89383202
36response to host (GO:0075136)3.89019592
37response to host defenses (GO:0052200)3.89019592
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.89019592
39myeloid cell activation involved in immune response (GO:0002275)3.86317689
40respiratory burst (GO:0045730)3.85622409
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.84673403
42leukocyte migration involved in inflammatory response (GO:0002523)3.84410473
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.83952664
44production of molecular mediator involved in inflammatory response (GO:0002532)3.79673473
45myeloid leukocyte mediated immunity (GO:0002444)3.78086444
46granulocyte activation (GO:0036230)3.74450372
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.69086186
48cellular response to type I interferon (GO:0071357)3.66773996
49type I interferon signaling pathway (GO:0060337)3.66773996
50response to type I interferon (GO:0034340)3.64493584
51regulation of mast cell degranulation (GO:0043304)3.61757567
52B cell mediated immunity (GO:0019724)3.55028250
53neutrophil mediated immunity (GO:0002446)3.53396981
54* interferon-gamma-mediated signaling pathway (GO:0060333)3.47692266
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46470994
56positive regulation of interferon-alpha production (GO:0032727)3.46240041
57regulation of hypersensitivity (GO:0002883)3.45606947
58negative regulation of leukocyte mediated immunity (GO:0002704)3.45528272
59regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.43879143
60regulation of mast cell activation involved in immune response (GO:0033006)3.39190112
61positive regulation of mast cell activation (GO:0033005)3.39035933
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35478557
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.31341530
64regulation of interferon-alpha production (GO:0032647)3.30887832
65germinal center formation (GO:0002467)3.29422244
66regulation of gamma-delta T cell differentiation (GO:0045586)3.28535526
67antigen processing and presentation via MHC class Ib (GO:0002475)3.27917047
68regulation of mast cell activation (GO:0033003)3.27335036
69response to muramyl dipeptide (GO:0032495)3.26893968
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.26061654
71negative regulation of T cell mediated immunity (GO:0002710)3.23272780
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21360936
73positive regulation of cellular amide metabolic process (GO:0034250)3.18546238
74regulation of T-helper 2 cell differentiation (GO:0045628)3.18412414
75positive regulation of mast cell degranulation (GO:0043306)3.16638072
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.16638072
77regulation of leukocyte degranulation (GO:0043300)3.15216517
78defense response to protozoan (GO:0042832)3.14572883
79positive regulation of toll-like receptor signaling pathway (GO:0034123)3.13552436
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07273156
81regulation of tolerance induction (GO:0002643)3.06849014
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06681849
83B cell receptor signaling pathway (GO:0050853)2.99997757
84T-helper 1 type immune response (GO:0042088)2.99786149
85negative regulation of T-helper cell differentiation (GO:0045623)2.99058583
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99058583
87myeloid leukocyte activation (GO:0002274)2.98857796
88response to interleukin-15 (GO:0070672)2.98344411
89regulation of T cell tolerance induction (GO:0002664)2.98050454
90positive regulation of antigen processing and presentation (GO:0002579)2.94431259
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93938632
92positive regulation of interferon-beta production (GO:0032728)2.91263451
93neutrophil chemotaxis (GO:0030593)2.87443189
94negative regulation of innate immune response (GO:0045824)2.86905753
95regulation of antigen processing and presentation (GO:0002577)2.86152614
96leukocyte degranulation (GO:0043299)2.84485040
97positive regulation of type 2 immune response (GO:0002830)2.82623665
98negative regulation of cytokine production involved in immune response (GO:0002719)2.80605399
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80449390
100neutrophil migration (GO:1990266)2.79878581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.39091258
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.01432431
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.41967970
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79355359
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.76569726
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65452709
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.60585009
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54361494
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50958146
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.27217016
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05928947
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02197282
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86443280
14SPI1_23547873_ChIP-Seq_NB4_Human2.67734790
15* SPI1_23127762_ChIP-Seq_K562_Human2.65764178
16VDR_24763502_ChIP-Seq_THP-1_Human2.58866995
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52736579
18RUNX_20019798_ChIP-Seq_JUKART_Human2.52001012
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49888810
20SCL_19346495_ChIP-Seq_HPC-7_Human2.44478189
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40306598
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34274522
23VDR_21846776_ChIP-Seq_THP-1_Human2.28865037
24VDR_24787735_ChIP-Seq_THP-1_Human2.25664026
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17014658
26MYB_26560356_Chip-Seq_TH2_Human2.14871854
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.14656827
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13548984
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04489650
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04151070
31MAF_26560356_Chip-Seq_TH1_Human1.99348602
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97442765
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.96349219
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81822114
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.77989567
36* MYB_26560356_Chip-Seq_TH1_Human1.76481066
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73744535
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67695351
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65256270
40UTX_26944678_Chip-Seq_JUKART_Human1.61540588
41GATA3_27048872_Chip-Seq_THYMUS_Human1.61368180
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.56388444
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53114887
44TCF7_22412390_ChIP-Seq_EML_Mouse1.51321320
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48744556
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48246448
47PU_27001747_Chip-Seq_BMDM_Mouse1.47230984
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45289968
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41823814
50GATA1_22025678_ChIP-Seq_K562_Human1.39918507
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38187323
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35914941
53GATA3_26560356_Chip-Seq_TH2_Human1.34845105
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32445918
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29506443
56MAF_26560356_Chip-Seq_TH2_Human1.28773417
57KDM2B_26808549_Chip-Seq_DND41_Human1.28216234
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26232534
59MYC_22102868_ChIP-Seq_BL_Human1.25839765
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24395255
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23668396
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22756887
63GATA1_19941826_ChIP-Seq_K562_Human1.21592469
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21513532
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19755486
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15755919
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14330460
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13415788
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11654849
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11483635
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10691300
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10449302
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10322311
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09976830
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09886882
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09336769
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08014687
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.06652041
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06571268
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00395280
81GATA2_19941826_ChIP-Seq_K562_Human0.97139450
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95406786
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92578917
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86667619
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.85812502
86SMRT_27268052_Chip-Seq_Bcells_Human0.85700316
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84373500
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.81996761
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81145627
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80986539
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78247443
92BCL6_27268052_Chip-Seq_Bcells_Human0.78186008
93LXR_22292898_ChIP-Seq_THP-1_Human0.74211668
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72762715
95BCOR_27268052_Chip-Seq_Bcells_Human0.72496338
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72318634
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72295922
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71758313
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70550203
100STAT1_20625510_ChIP-Seq_HELA_Human0.70471704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.10866339
2MP0001835_abnormal_antigen_presentation3.95830532
3MP0003303_peritoneal_inflammation3.69549882
4MP0003436_decreased_susceptibility_to3.67276237
5MP0002419_abnormal_innate_immunity3.17615249
6MP0009785_altered_susceptibility_to3.15596612
7MP0006082_CNS_inflammation3.06463511
8MP0005025_abnormal_response_to2.88947584
9MP0000685_abnormal_immune_system2.84828513
10MP0005671_abnormal_response_to2.82785195
11MP0001790_abnormal_immune_system2.76549545
12MP0005387_immune_system_phenotype2.76549545
13MP0001800_abnormal_humoral_immune2.74871791
14MP0005000_abnormal_immune_tolerance2.70891377
15MP0008260_abnormal_autophagy2.62184999
16MP0002148_abnormal_hypersensitivity_rea2.52851566
17MP0002723_abnormal_immune_serum2.51979090
18MP0002452_abnormal_antigen_presenting2.49177596
19MP0002420_abnormal_adaptive_immunity2.31871138
20MP0001819_abnormal_immune_cell2.30406043
21MP0003300_gastrointestinal_ulcer2.29961328
22MP0003172_abnormal_lysosome_physiology2.29306681
23MP0003191_abnormal_cellular_cholesterol2.23387495
24MP0001533_abnormal_skeleton_physiology2.08396631
25MP0000569_abnormal_digit_pigmentation2.03906608
26MP0005464_abnormal_platelet_physiology1.96824035
27MP0002405_respiratory_system_inflammati1.91749937
28MP0009278_abnormal_bone_marrow1.89735389
29MP0001845_abnormal_inflammatory_respons1.80142365
30MP0005058_abnormal_lysosome_morphology1.79141809
31MP0009764_decreased_sensitivity_to1.74728768
32MP0000716_abnormal_immune_system1.70860715
33MP0003828_pulmonary_edema1.66571563
34MP0005310_abnormal_salivary_gland1.65955162
35MP0004883_abnormal_blood_vessel1.64572299
36MP0002398_abnormal_bone_marrow1.62953602
37MP0004947_skin_inflammation1.59324201
38MP0003690_abnormal_glial_cell1.55852886
39MP0010155_abnormal_intestine_physiology1.53290546
40MP0001545_abnormal_hematopoietic_system1.52656656
41MP0005397_hematopoietic_system_phenotyp1.52656656
42MP0008469_abnormal_protein_level1.50202643
43MP0003075_altered_response_to1.49470209
44MP0005451_abnormal_body_composition1.48020048
45MP0003763_abnormal_thymus_physiology1.45380527
46MP0002166_altered_tumor_susceptibility1.42148574
47MP0000689_abnormal_spleen_morphology1.39142758
48MP0004510_myositis1.38705909
49MP0002998_abnormal_bone_remodeling1.35664121
50MP0002277_abnormal_respiratory_mucosa1.35303680
51MP0004381_abnormal_hair_follicle1.34208585
52MP0002722_abnormal_immune_system1.33932655
53MP0000604_amyloidosis1.33154342
54MP0000858_altered_metastatic_potential1.32583846
55MP0002429_abnormal_blood_cell1.31659504
56MP0000343_altered_response_to1.31075278
57MP0005164_abnormal_response_to1.30614699
58MP0000465_gastrointestinal_hemorrhage1.29909003
59MP0002132_abnormal_respiratory_system1.27732484
60MP0003866_abnormal_defecation1.27095348
61MP0003183_abnormal_peptide_metabolism1.22698172
62MP0009333_abnormal_splenocyte_physiolog1.19452628
63MP0003656_abnormal_erythrocyte_physiolo1.16574619
64MP0001853_heart_inflammation1.14524015
65MP0001851_eye_inflammation1.10667670
66MP0009840_abnormal_foam_cell1.10003306
67MP0002396_abnormal_hematopoietic_system1.08119665
68MP0005166_decreased_susceptibility_to1.03796154
69MP0000703_abnormal_thymus_morphology1.02931810
70MP0003448_altered_tumor_morphology1.02189846
71MP0000015_abnormal_ear_pigmentation0.97177253
72MP0002006_tumorigenesis0.95137643
73MP0005167_abnormal_blood-brain_barrier0.91319097
74MP0009763_increased_sensitivity_to0.89712487
75MP0003806_abnormal_nucleotide_metabolis0.88073809
76MP0005075_abnormal_melanosome_morpholog0.84513521
77MP0003221_abnormal_cardiomyocyte_apopto0.83942894
78MP0004808_abnormal_hematopoietic_stem0.82177037
79MP0002332_abnormal_exercise_endurance0.80374140
80MP0003195_calcinosis0.77952621
81MP0008004_abnormal_stomach_pH0.76728218
82MP0005390_skeleton_phenotype0.75175137
83MP0003329_amyloid_beta_deposits0.71877381
84MP0000249_abnormal_blood_vessel0.71052376
85MP0001663_abnormal_digestive_system0.70959950
86MP0003787_abnormal_imprinting0.69434309
87MP0005174_abnormal_tail_pigmentation0.67777202
88MP0008874_decreased_physiological_sensi0.67330213
89MP0003045_fibrosis0.65829841
90MP0009765_abnormal_xenobiotic_induced0.64281750
91MP0002138_abnormal_hepatobiliary_system0.64188440
92MP0003795_abnormal_bone_structure0.63515999
93MP0000920_abnormal_myelination0.61927303
94MP0003091_abnormal_cell_migration0.60428348
95MP0004484_altered_response_of0.59932529
96MP0004130_abnormal_muscle_cell0.58529605
97MP0002933_joint_inflammation0.57778478
98MP0006054_spinal_hemorrhage0.55889611
99MP0000371_diluted_coat_color0.54818543
100MP0005376_homeostasis/metabolism_phenot0.53112130

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.49198876
2Eczematoid dermatitis (HP:0000976)6.40741450
3Recurrent abscess formation (HP:0002722)6.28164223
4Myositis (HP:0100614)5.56238924
5Orchitis (HP:0100796)5.50797541
6Abnormality of macrophages (HP:0004311)5.40978292
7Retrobulbar optic neuritis (HP:0100654)5.37546977
8Optic neuritis (HP:0100653)5.37546977
9Recurrent gram-negative bacterial infections (HP:0005420)5.01677979
10Elevated erythrocyte sedimentation rate (HP:0003565)4.65208129
11Mediastinal lymphadenopathy (HP:0100721)4.38220567
12Stomatitis (HP:0010280)4.32476423
13Gastrointestinal infarctions (HP:0005244)4.20677461
14Recurrent skin infections (HP:0001581)4.18579699
15Recurrent fungal infections (HP:0002841)4.09028166
16Chronic obstructive pulmonary disease (HP:0006510)3.81726225
17Obstructive lung disease (HP:0006536)3.81726225
18Keratoconjunctivitis sicca (HP:0001097)3.81220627
19Gingivitis (HP:0000230)3.79428135
20Meningitis (HP:0001287)3.75286974
21Chronic mucocutaneous candidiasis (HP:0002728)3.66899370
22Recurrent cutaneous fungal infections (HP:0011370)3.66899370
23Spontaneous hematomas (HP:0007420)3.66532514
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.57602305
25Keratoconjunctivitis (HP:0001096)3.51318933
26Encephalitis (HP:0002383)3.43324568
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33784784
28Hemoptysis (HP:0002105)3.26418343
29Vasculitis (HP:0002633)3.25402775
30Urticaria (HP:0001025)3.24385724
31Peritonitis (HP:0002586)3.18158790
32Abnormality of liposaccharide metabolism (HP:0010968)3.12463993
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.12463993
34Abnormality of glycolipid metabolism (HP:0010969)3.12463993
35Amyloidosis (HP:0011034)3.11431725
36Chest pain (HP:0100749)3.09338628
37T lymphocytopenia (HP:0005403)3.08494609
38Arterial thrombosis (HP:0004420)3.08210446
39Systemic lupus erythematosus (HP:0002725)3.06390621
40Pulmonary infiltrates (HP:0002113)3.05636115
41Abnormality of T cell number (HP:0011839)3.03333973
42Gingival bleeding (HP:0000225)2.93905842
43Increased cerebral lipofuscin (HP:0011813)2.91532389
44Cellulitis (HP:0100658)2.85596073
45Leukocytosis (HP:0001974)2.81026571
46Increased IgE level (HP:0003212)2.79200790
47Episodic fever (HP:0001954)2.77671294
48Recurrent viral infections (HP:0004429)2.72979543
49Anorexia (HP:0002039)2.67702416
50Pulmonary embolism (HP:0002204)2.65909531
51Hypochromic microcytic anemia (HP:0004840)2.63359318
52Osteomyelitis (HP:0002754)2.62578101
53Prolonged bleeding time (HP:0003010)2.57418192
54Epistaxis (HP:0000421)2.55638465
55Abnormality of the peritoneum (HP:0002585)2.52526085
56Chronic otitis media (HP:0000389)2.50217477
57Hypochromic anemia (HP:0001931)2.48639131
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.45773023
59Autoimmune thrombocytopenia (HP:0001973)2.44050547
60Disinhibition (HP:0000734)2.43487568
61Gangrene (HP:0100758)2.41191631
62Abnormality of T cells (HP:0002843)2.38490039
63Inflammation of the large intestine (HP:0002037)2.37878324
64Loss of speech (HP:0002371)2.35996986
65Abnormality of the pleura (HP:0002103)2.35178787
66Gastrointestinal inflammation (HP:0004386)2.22959442
67Vertigo (HP:0002321)2.21986562
68Abnormality of the endocardium (HP:0004306)2.21199901
69Increased IgM level (HP:0003496)2.21168298
70Slow saccadic eye movements (HP:0000514)2.15605911
71Granulocytopenia (HP:0001913)2.15224176
72Sepsis (HP:0100806)2.10754674
73Pustule (HP:0200039)2.10310435
74Glomerulonephritis (HP:0000099)2.08595491
75Hypergammaglobulinemia (HP:0010702)2.08350702
76Microcytic anemia (HP:0001935)2.08179170
77Increased serum ferritin (HP:0003281)2.06200194
78Glomerulopathy (HP:0100820)2.05745254
79Eosinophilia (HP:0001880)2.03305704
80Petechiae (HP:0000967)2.03241286
81Colitis (HP:0002583)2.01729903
82Cheilitis (HP:0100825)2.00813496
83Recurrent bronchitis (HP:0002837)2.00340114
84Panhypogammaglobulinemia (HP:0003139)2.00130720
85Premature loss of primary teeth (HP:0006323)1.96251849
86Polyneuropathy (HP:0001271)1.96135914
87Purpura (HP:0000979)1.94298529
88Abnormality of iron homeostasis (HP:0011031)1.94220231
89Abnormality of T cell physiology (HP:0011840)1.93747966
90Dysostosis multiplex (HP:0000943)1.92947704
91Keratitis (HP:0000491)1.90701349
92Abnormality of the pericardium (HP:0001697)1.90183946
93Skin ulcer (HP:0200042)1.89981903
94Recurrent pneumonia (HP:0006532)1.89418532
95Acne (HP:0001061)1.86487008
96Mutism (HP:0002300)1.86159637
97Acute hepatic failure (HP:0006554)1.84311159
98Thrombophlebitis (HP:0004418)1.84180212
99Postural instability (HP:0002172)1.82405938
100Vacuolated lymphocytes (HP:0001922)1.81883481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.77255149
2BLK3.92987893
3IRAK43.14925632
4TYK23.09118389
5MAP2K32.86754422
6MAP4K12.86682545
7CSK2.77175345
8FGR2.33678744
9FES2.30200176
10JAK32.23193787
11ERN12.10238023
12IKBKE2.03196045
13ZAP702.02646533
14MAP3K142.02142129
15TNK21.98963877
16TXK1.98438736
17GRK61.92619955
18SYK1.72380088
19BTK1.70469244
20EPHB11.68595768
21JAK11.61918214
22HCK1.60617109
23JAK21.58115297
24TAOK11.56224296
25TBK11.55809298
26LYN1.47090597
27MATK1.46480514
28MAP3K131.46478673
29MAP3K31.43751188
30MAP3K111.37188745
31IRAK11.36206364
32CSF1R1.35666619
33KIT1.31861069
34TGFBR21.31251270
35TAOK31.28401257
36PRPF4B1.22834807
37IRAK21.22000595
38MAP3K11.19675238
39MAP3K61.15497985
40BMPR21.13915157
41IKBKB1.13399979
42YES11.12335509
43LCK1.11432265
44GRK71.07699785
45MARK31.03229787
46KSR21.00479151
47ITK0.98689728
48TEC0.98470919
49MARK20.95107009
50CAMK1D0.91847375
51PDK10.84230389
52MAP3K50.83934971
53FGFR30.83915627
54PTK2B0.79804894
55SIK30.79326373
56MAP3K20.78954960
57PIK3CG0.78534185
58CDC42BPA0.74820575
59PDPK10.72977167
60FGFR40.72579965
61TAOK20.72478119
62CAMKK20.71386326
63STK100.71227004
64LRRK20.68843649
65IRAK30.68821715
66SIK20.65006369
67EPHA30.64863573
68MAP2K40.62279706
69FYN0.61683036
70PTK60.61146348
71SGK30.58581950
72PIM10.57041946
73MAP2K60.54094575
74PRKD20.52839596
75SGK20.51398450
76KSR10.51152829
77ACVR1B0.50903529
78STK110.49346157
79CHUK0.47448193
80HIPK20.46891293
81RET0.46161019
82CAMK1G0.44955648
83MAPK70.44232602
84MAPK120.43990002
85WNK10.43014687
86CDK190.41243437
87RPS6KL10.40195576
88RPS6KC10.40195576
89MAP3K70.40135579
90MAPKAPK20.39625444
91FRK0.38841164
92DYRK1B0.38422763
93DAPK20.38153687
94CAMK40.37616486
95CDK60.37262675
96MOS0.36933211
97RPS6KA60.36444882
98DYRK30.34081170
99TRIB30.33387823
100GRK50.33007738

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.44721665
2Leishmaniasis_Homo sapiens_hsa051403.30468356
3Osteoclast differentiation_Homo sapiens_hsa043803.12534362
4Tuberculosis_Homo sapiens_hsa051522.39385385
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39027204
6Allograft rejection_Homo sapiens_hsa053302.30476256
7Graft-versus-host disease_Homo sapiens_hsa053322.28868930
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18617423
9Autoimmune thyroid disease_Homo sapiens_hsa053202.09310490
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08817085
11B cell receptor signaling pathway_Homo sapiens_hsa046622.05017449
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97657321
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95797729
14Legionellosis_Homo sapiens_hsa051341.89435474
15Malaria_Homo sapiens_hsa051441.88119775
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77158615
17Antigen processing and presentation_Homo sapiens_hsa046121.72095827
18Type I diabetes mellitus_Homo sapiens_hsa049401.71076923
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.70339969
20Measles_Homo sapiens_hsa051621.69886173
21Phagosome_Homo sapiens_hsa041451.66329993
22Chemokine signaling pathway_Homo sapiens_hsa040621.62403319
23Influenza A_Homo sapiens_hsa051641.61958633
24Toxoplasmosis_Homo sapiens_hsa051451.58300624
25Hematopoietic cell lineage_Homo sapiens_hsa046401.55461778
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54743693
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52064611
28Primary immunodeficiency_Homo sapiens_hsa053401.50882548
29Asthma_Homo sapiens_hsa053101.48489523
30Other glycan degradation_Homo sapiens_hsa005111.46263367
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44125679
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.43280769
33Pertussis_Homo sapiens_hsa051331.40431935
34Rheumatoid arthritis_Homo sapiens_hsa053231.35614967
35TNF signaling pathway_Homo sapiens_hsa046681.32830132
36Acute myeloid leukemia_Homo sapiens_hsa052211.31191252
37Herpes simplex infection_Homo sapiens_hsa051681.31091265
38Viral myocarditis_Homo sapiens_hsa054161.30978055
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.28620823
40T cell receptor signaling pathway_Homo sapiens_hsa046601.27070472
41Lysosome_Homo sapiens_hsa041421.25429293
42African trypanosomiasis_Homo sapiens_hsa051431.23155598
43Salmonella infection_Homo sapiens_hsa051321.08321941
44Hepatitis C_Homo sapiens_hsa051601.07856740
45Hepatitis B_Homo sapiens_hsa051611.07763321
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04570099
47Platelet activation_Homo sapiens_hsa046111.03327216
48Non-small cell lung cancer_Homo sapiens_hsa052230.99010329
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97999181
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.94510368
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92029392
52Prolactin signaling pathway_Homo sapiens_hsa049170.89412847
53Apoptosis_Homo sapiens_hsa042100.88244452
54Shigellosis_Homo sapiens_hsa051310.85164539
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82960316
56Pancreatic cancer_Homo sapiens_hsa052120.82704692
57VEGF signaling pathway_Homo sapiens_hsa043700.76521718
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74424329
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74253402
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.71685499
61Chronic myeloid leukemia_Homo sapiens_hsa052200.70311562
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.68173719
63Dorso-ventral axis formation_Homo sapiens_hsa043200.67121489
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66616716
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.66335357
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64990728
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.64426707
68Renal cell carcinoma_Homo sapiens_hsa052110.63812554
69FoxO signaling pathway_Homo sapiens_hsa040680.63482153
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62443109
71Viral carcinogenesis_Homo sapiens_hsa052030.61842842
72Amoebiasis_Homo sapiens_hsa051460.60256258
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58929989
74Notch signaling pathway_Homo sapiens_hsa043300.58865471
75Endocytosis_Homo sapiens_hsa041440.58775940
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.58267334
77Complement and coagulation cascades_Homo sapiens_hsa046100.57582770
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54682578
79Epstein-Barr virus infection_Homo sapiens_hsa051690.54350837
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54124622
81Systemic lupus erythematosus_Homo sapiens_hsa053220.53970417
82HIF-1 signaling pathway_Homo sapiens_hsa040660.52875713
83GnRH signaling pathway_Homo sapiens_hsa049120.51645477
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50254825
85Type II diabetes mellitus_Homo sapiens_hsa049300.49885173
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47408687
87Choline metabolism in cancer_Homo sapiens_hsa052310.40821640
88Endometrial cancer_Homo sapiens_hsa052130.40145334
89MAPK signaling pathway_Homo sapiens_hsa040100.39947577
90Regulation of autophagy_Homo sapiens_hsa041400.39748086
91HTLV-I infection_Homo sapiens_hsa051660.38391384
92Inositol phosphate metabolism_Homo sapiens_hsa005620.38048632
93Collecting duct acid secretion_Homo sapiens_hsa049660.36665055
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35467325
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34920686
96Estrogen signaling pathway_Homo sapiens_hsa049150.33749847
97Insulin resistance_Homo sapiens_hsa049310.33359503
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33052796
99mTOR signaling pathway_Homo sapiens_hsa041500.32886286
100Rap1 signaling pathway_Homo sapiens_hsa040150.31720574

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