FCGR1CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.09351636
2modulation by symbiont of host defense response (GO:0052031)6.09351636
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.09351636
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.09351636
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.09351636
6modulation by symbiont of host immune response (GO:0052553)6.09351636
7neutrophil activation involved in immune response (GO:0002283)5.44178877
8macrophage activation involved in immune response (GO:0002281)5.43064687
9immunoglobulin mediated immune response (GO:0016064)5.39904126
10response to peptidoglycan (GO:0032494)5.25876508
11detection of molecule of bacterial origin (GO:0032490)5.15837880
12negative regulation of interleukin-12 production (GO:0032695)5.14679523
13positive regulation of gamma-delta T cell activation (GO:0046645)5.05275702
14detection of other organism (GO:0098543)4.95605462
15microglial cell activation (GO:0001774)4.92984305
16negative regulation of cell killing (GO:0031342)4.88936772
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88936772
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77194887
19detection of external biotic stimulus (GO:0098581)4.65377440
20detection of bacterium (GO:0016045)4.60663402
21positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.53953070
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49196250
23regulation of hypersensitivity (GO:0002883)4.41605504
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39653408
25antigen processing and presentation of endogenous antigen (GO:0019883)4.38411901
26B cell mediated immunity (GO:0019724)4.26953520
27regulation of interferon-beta biosynthetic process (GO:0045357)4.23736327
28cellular extravasation (GO:0045123)4.21057349
29response to host immune response (GO:0052572)4.16551570
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.16551570
31detection of biotic stimulus (GO:0009595)4.14742339
32macrophage activation (GO:0042116)4.10245921
33interferon-gamma-mediated signaling pathway (GO:0060333)4.08390646
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08119291
35leukocyte aggregation (GO:0070486)4.05976055
36regulation of myeloid leukocyte mediated immunity (GO:0002886)4.04565464
37leukocyte migration involved in inflammatory response (GO:0002523)3.97422155
38production of molecular mediator involved in inflammatory response (GO:0002532)3.94203475
39myeloid cell activation involved in immune response (GO:0002275)3.92187599
40respiratory burst (GO:0045730)3.80279617
41type I interferon signaling pathway (GO:0060337)3.77569162
42cellular response to type I interferon (GO:0071357)3.77569162
43response to host defenses (GO:0052200)3.74560516
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74560516
45response to host (GO:0075136)3.74560516
46response to type I interferon (GO:0034340)3.72915478
47neutrophil activation (GO:0042119)3.69934915
48regulation of mast cell degranulation (GO:0043304)3.66288841
49granulocyte activation (GO:0036230)3.65608032
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.64974096
51myeloid leukocyte mediated immunity (GO:0002444)3.62587584
52regulation of B cell receptor signaling pathway (GO:0050855)3.61379080
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.57377037
54regulation of gamma-delta T cell activation (GO:0046643)3.55807531
55positive regulation of interferon-alpha production (GO:0032727)3.53959790
56positive regulation of mast cell activation (GO:0033005)3.49991811
57positive regulation of type 2 immune response (GO:0002830)3.48520027
58positive regulation of mast cell activation involved in immune response (GO:0033008)3.45250988
59positive regulation of mast cell degranulation (GO:0043306)3.45250988
60regulation of interferon-alpha production (GO:0032647)3.42134900
61regulation of T cell tolerance induction (GO:0002664)3.40384239
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.40113561
63regulation of mast cell activation involved in immune response (GO:0033006)3.39412090
64regulation of tolerance induction (GO:0002643)3.38431611
65regulation of T-helper 2 cell differentiation (GO:0045628)3.37609179
66phagocytosis, engulfment (GO:0006911)3.34247498
67response to muramyl dipeptide (GO:0032495)3.33714179
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.32368787
69regulation of mast cell activation (GO:0033003)3.27062179
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25411680
71positive regulation of toll-like receptor signaling pathway (GO:0034123)3.23896142
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22189049
73regulation of leukocyte degranulation (GO:0043300)3.18901358
74cellular response to interferon-gamma (GO:0071346)3.16320790
75negative regulation of leukocyte mediated immunity (GO:0002704)3.14697932
76positive regulation of antigen processing and presentation (GO:0002579)3.13525531
77positive regulation of cellular amide metabolic process (GO:0034250)3.12811107
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12385291
79T-helper 1 type immune response (GO:0042088)3.10850793
80regulation of antigen processing and presentation (GO:0002577)3.09797139
81defense response to protozoan (GO:0042832)3.08002790
82phagocytosis, recognition (GO:0006910)3.07957788
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07471365
84neutrophil mediated immunity (GO:0002446)3.05689895
85response to interferon-gamma (GO:0034341)3.04057673
86neutrophil chemotaxis (GO:0030593)3.03870678
87antigen processing and presentation via MHC class Ib (GO:0002475)3.03142099
88germinal center formation (GO:0002467)2.97973777
89regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.97328483
90myeloid leukocyte activation (GO:0002274)2.97264701
91neutrophil migration (GO:1990266)2.95956190
92response to interferon-beta (GO:0035456)2.95263697
93negative regulation of innate immune response (GO:0045824)2.94363168
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94189837
95negative regulation of T cell mediated immunity (GO:0002710)2.92768139
96negative regulation of cytokine production involved in immune response (GO:0002719)2.89873964
97positive regulation of interferon-beta production (GO:0032728)2.89832999
98regulation of type 2 immune response (GO:0002828)2.89612446
99T cell migration (GO:0072678)2.88256993
100response to interferon-alpha (GO:0035455)2.85423346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.66862416
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.23314857
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.17429746
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.95276957
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94282737
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62120545
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.61537173
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32595972
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.17626570
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13979902
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09677113
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06635215
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93309564
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75787111
15SPI1_23547873_ChIP-Seq_NB4_Human2.73949511
16VDR_24763502_ChIP-Seq_THP-1_Human2.69604826
17SPI1_23127762_ChIP-Seq_K562_Human2.62231149
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.57762092
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46918790
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46800270
21VDR_21846776_ChIP-Seq_THP-1_Human2.36790887
22VDR_24787735_ChIP-Seq_THP-1_Human2.30240437
23RUNX_20019798_ChIP-Seq_JUKART_Human2.28229071
24SCL_19346495_ChIP-Seq_HPC-7_Human2.28222409
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24072126
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18888656
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13206788
28MYB_26560356_Chip-Seq_TH2_Human1.96859732
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.96321208
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.88263319
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88255137
32MAF_26560356_Chip-Seq_TH1_Human1.86177196
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82829585
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73852478
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73123182
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72762114
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72147503
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.69526633
39GATA1_22025678_ChIP-Seq_K562_Human1.62210895
40MYB_26560356_Chip-Seq_TH1_Human1.61650328
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59200192
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55409547
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53386015
44UTX_26944678_Chip-Seq_JUKART_Human1.51217659
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49275861
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.48190139
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48179205
48PU_27001747_Chip-Seq_BMDM_Mouse1.45188255
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44663151
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44185162
51GATA3_27048872_Chip-Seq_THYMUS_Human1.41349453
52TCF7_22412390_ChIP-Seq_EML_Mouse1.36356242
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35871141
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35066347
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34933410
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27393662
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26774689
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26527890
59GATA3_26560356_Chip-Seq_TH2_Human1.26229992
60MAF_26560356_Chip-Seq_TH2_Human1.24405857
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23893960
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23449921
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22790383
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22448410
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19979961
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18559580
67KDM2B_26808549_Chip-Seq_DND41_Human1.18221323
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17140626
69MYC_22102868_ChIP-Seq_BL_Human1.15443406
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10957233
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10153398
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08745233
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08172271
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07508822
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04839138
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.04715470
77GATA1_19941826_ChIP-Seq_K562_Human1.02629737
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01990210
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00870224
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97884597
81ELK3_25401928_ChIP-Seq_HUVEC_Human0.95914389
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95455647
83LXR_22292898_ChIP-Seq_THP-1_Human0.95073928
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90055718
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89276884
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88794214
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88672739
88BCL6_27268052_Chip-Seq_Bcells_Human0.88628744
89STAT1_20625510_ChIP-Seq_HELA_Human0.84421980
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84087156
91TFEB_21752829_ChIP-Seq_HELA_Human0.81913963
92GATA2_19941826_ChIP-Seq_K562_Human0.81643028
93BCOR_27268052_Chip-Seq_Bcells_Human0.79255299
94SMRT_27268052_Chip-Seq_Bcells_Human0.78560650
95SPI1_20517297_ChIP-Seq_HL60_Human0.75717388
96EGR1_19032775_ChIP-ChIP_M12_Human0.73826448
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72306909
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70072119
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68761510
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.65745358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.77209154
2MP0001835_abnormal_antigen_presentation4.11845217
3MP0003436_decreased_susceptibility_to3.65256313
4MP0003303_peritoneal_inflammation3.52634010
5MP0006082_CNS_inflammation3.36857405
6MP0009785_altered_susceptibility_to3.32782697
7MP0002419_abnormal_innate_immunity3.29858611
8MP0005671_abnormal_response_to3.07405831
9MP0005025_abnormal_response_to2.99952517
10MP0002148_abnormal_hypersensitivity_rea2.95936725
11MP0001790_abnormal_immune_system2.93290815
12MP0005387_immune_system_phenotype2.93290815
13MP0005000_abnormal_immune_tolerance2.86357932
14MP0000685_abnormal_immune_system2.78829883
15MP0001800_abnormal_humoral_immune2.68387169
16MP0003191_abnormal_cellular_cholesterol2.59829263
17MP0002452_abnormal_antigen_presenting2.55392917
18MP0002723_abnormal_immune_serum2.54445119
19MP0003172_abnormal_lysosome_physiology2.36218789
20MP0002420_abnormal_adaptive_immunity2.30113375
21MP0001819_abnormal_immune_cell2.29350383
22MP0003300_gastrointestinal_ulcer2.27614836
23MP0005058_abnormal_lysosome_morphology2.27538157
24MP0001533_abnormal_skeleton_physiology2.12807779
25MP0008260_abnormal_autophagy2.09269034
26MP0005464_abnormal_platelet_physiology2.08595678
27MP0009840_abnormal_foam_cell1.99878731
28MP0009278_abnormal_bone_marrow1.98626698
29MP0001845_abnormal_inflammatory_respons1.89746340
30MP0009764_decreased_sensitivity_to1.80752457
31MP0002405_respiratory_system_inflammati1.78111826
32MP0000343_altered_response_to1.73334319
33MP0003075_altered_response_to1.67053869
34MP0000569_abnormal_digit_pigmentation1.66287760
35MP0000716_abnormal_immune_system1.65698555
36MP0008469_abnormal_protein_level1.63736247
37MP0003828_pulmonary_edema1.59836416
38MP0000604_amyloidosis1.59357398
39MP0003690_abnormal_glial_cell1.57905398
40MP0005310_abnormal_salivary_gland1.56568142
41MP0010155_abnormal_intestine_physiology1.55417755
42MP0002398_abnormal_bone_marrow1.51126123
43MP0005397_hematopoietic_system_phenotyp1.49364255
44MP0001545_abnormal_hematopoietic_system1.49364255
45MP0002277_abnormal_respiratory_mucosa1.49239545
46MP0004883_abnormal_blood_vessel1.46873993
47MP0004947_skin_inflammation1.46068615
48MP0002998_abnormal_bone_remodeling1.44588532
49MP0004510_myositis1.40051649
50MP0000465_gastrointestinal_hemorrhage1.36788352
51MP0003806_abnormal_nucleotide_metabolis1.32231115
52MP0000858_altered_metastatic_potential1.31449739
53MP0009333_abnormal_splenocyte_physiolog1.29563259
54MP0000689_abnormal_spleen_morphology1.28186254
55MP0002429_abnormal_blood_cell1.27751941
56MP0005164_abnormal_response_to1.27318542
57MP0002166_altered_tumor_susceptibility1.27124734
58MP0003763_abnormal_thymus_physiology1.20789746
59MP0002722_abnormal_immune_system1.20445142
60MP0005451_abnormal_body_composition1.18193561
61MP0003183_abnormal_peptide_metabolism1.17636335
62MP0003448_altered_tumor_morphology1.16459940
63MP0005166_decreased_susceptibility_to1.16054732
64MP0003866_abnormal_defecation1.10078589
65MP0001853_heart_inflammation1.09232335
66MP0002132_abnormal_respiratory_system1.04475306
67MP0009763_increased_sensitivity_to0.99544077
68MP0005167_abnormal_blood-brain_barrier0.99182214
69MP0003195_calcinosis0.98578863
70MP0001851_eye_inflammation0.91585724
71MP0000920_abnormal_myelination0.91432049
72MP0000015_abnormal_ear_pigmentation0.89532368
73MP0003656_abnormal_erythrocyte_physiolo0.86754039
74MP0002006_tumorigenesis0.85295751
75MP0002396_abnormal_hematopoietic_system0.83601606
76MP0005390_skeleton_phenotype0.81969394
77MP0000703_abnormal_thymus_morphology0.79831843
78MP0008004_abnormal_stomach_pH0.77975166
79MP0003329_amyloid_beta_deposits0.76371636
80MP0000249_abnormal_blood_vessel0.75051664
81MP0001663_abnormal_digestive_system0.72297893
82MP0004808_abnormal_hematopoietic_stem0.69811997
83MP0003795_abnormal_bone_structure0.68760855
84MP0004381_abnormal_hair_follicle0.67230299
85MP0008874_decreased_physiological_sensi0.65980431
86MP0005174_abnormal_tail_pigmentation0.62113132
87MP0009765_abnormal_xenobiotic_induced0.61732115
88MP0000371_diluted_coat_color0.60827227
89MP0002933_joint_inflammation0.59557057
90MP0005319_abnormal_enzyme/_coenzyme0.57232350
91MP0003221_abnormal_cardiomyocyte_apopto0.55369087
92MP0002332_abnormal_exercise_endurance0.53524794
93MP0005584_abnormal_enzyme/coenzyme_acti0.52694859
94MP0004484_altered_response_of0.52043534
95MP0002009_preneoplasia0.51784263
96MP0003091_abnormal_cell_migration0.50746556
97MP0001542_abnormal_bone_strength0.48240766
98MP0000609_abnormal_liver_physiology0.46726063
99MP0005165_increased_susceptibility_to0.46671130
100MP0001986_abnormal_taste_sensitivity0.45799637

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.54405916
2Recurrent abscess formation (HP:0002722)6.38187388
3Eczematoid dermatitis (HP:0000976)6.09662529
4Abnormality of macrophages (HP:0004311)5.72188102
5Myositis (HP:0100614)5.28737692
6Orchitis (HP:0100796)5.13309190
7Recurrent gram-negative bacterial infections (HP:0005420)4.96256229
8Optic neuritis (HP:0100653)4.94260350
9Retrobulbar optic neuritis (HP:0100654)4.94260350
10Systemic lupus erythematosus (HP:0002725)4.89594376
11Mediastinal lymphadenopathy (HP:0100721)4.33766488
12Recurrent skin infections (HP:0001581)4.20643820
13Stomatitis (HP:0010280)4.12578935
14Abnormality of liposaccharide metabolism (HP:0010968)4.10857409
15Abnormality of glycosphingolipid metabolism (HP:0004343)4.10857409
16Abnormality of glycolipid metabolism (HP:0010969)4.10857409
17Elevated erythrocyte sedimentation rate (HP:0003565)4.06744319
18Obstructive lung disease (HP:0006536)3.84475658
19Chronic obstructive pulmonary disease (HP:0006510)3.84475658
20Recurrent fungal infections (HP:0002841)3.79543819
21Spontaneous hematomas (HP:0007420)3.77928100
22Gingivitis (HP:0000230)3.68424918
23Gastrointestinal infarctions (HP:0005244)3.67685037
24Recurrent cutaneous fungal infections (HP:0011370)3.64339914
25Chronic mucocutaneous candidiasis (HP:0002728)3.64339914
26Meningitis (HP:0001287)3.61662160
27Keratoconjunctivitis sicca (HP:0001097)3.46882184
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.36615045
29Glomerulonephritis (HP:0000099)3.35006352
30Amyloidosis (HP:0011034)3.26202268
31Hemoptysis (HP:0002105)3.21430002
32Keratoconjunctivitis (HP:0001096)3.19695455
33Encephalitis (HP:0002383)3.18425356
34Urticaria (HP:0001025)3.18126216
35Increased cerebral lipofuscin (HP:0011813)3.10940438
36Vasculitis (HP:0002633)3.08905780
37Pulmonary infiltrates (HP:0002113)3.06812440
38Disinhibition (HP:0000734)2.99841894
39Loss of speech (HP:0002371)2.80974366
40Chest pain (HP:0100749)2.78156327
41Peritonitis (HP:0002586)2.73101234
42Cellulitis (HP:0100658)2.73055034
43Arterial thrombosis (HP:0004420)2.67684398
44Episodic fever (HP:0001954)2.64185338
45Recurrent viral infections (HP:0004429)2.62530574
46Premature loss of primary teeth (HP:0006323)2.61841420
47Osteomyelitis (HP:0002754)2.58713592
48Leukocytosis (HP:0001974)2.53913074
49Gingival bleeding (HP:0000225)2.53748081
50Vacuolated lymphocytes (HP:0001922)2.53516098
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.53100625
52Anorexia (HP:0002039)2.51853464
53T lymphocytopenia (HP:0005403)2.50147154
54Increased IgE level (HP:0003212)2.49266402
55Abnormality of T cell number (HP:0011839)2.48585263
56Pulmonary embolism (HP:0002204)2.46444180
57Mutism (HP:0002300)2.46040262
58Dysostosis multiplex (HP:0000943)2.45550777
59Chronic otitis media (HP:0000389)2.45494640
60Pustule (HP:0200039)2.43975154
61Epistaxis (HP:0000421)2.41072098
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37952770
63Prolonged bleeding time (HP:0003010)2.35905362
64Petechiae (HP:0000967)2.33199478
65Autoimmune thrombocytopenia (HP:0001973)2.32607588
66Abnormality of the peritoneum (HP:0002585)2.31499185
67Increased serum ferritin (HP:0003281)2.30659765
68Increased IgM level (HP:0003496)2.30579956
69Purpura (HP:0000979)2.28892893
70Complement deficiency (HP:0004431)2.27713178
71Gangrene (HP:0100758)2.23088505
72Abnormality of the pleura (HP:0002103)2.20407091
73Inflammation of the large intestine (HP:0002037)2.17623393
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15386631
75Abnormality of iron homeostasis (HP:0011031)2.13501484
76Abnormality of the endocardium (HP:0004306)2.10749792
77Hypergammaglobulinemia (HP:0010702)2.10642050
78Panhypogammaglobulinemia (HP:0003139)2.09912237
79Vertigo (HP:0002321)2.08663394
80Cheilitis (HP:0100825)2.07604741
81Gastrointestinal inflammation (HP:0004386)2.06383800
82Malnutrition (HP:0004395)2.04107409
83Abnormality of T cells (HP:0002843)2.02876148
84Agnosia (HP:0010524)2.02015985
85Glomerulopathy (HP:0100820)2.01550444
86Hepatosplenomegaly (HP:0001433)2.00830925
87Sepsis (HP:0100806)2.00400276
88Hypochromic anemia (HP:0001931)1.99984259
89Abnormality of complement system (HP:0005339)1.99910227
90Axonal loss (HP:0003447)1.98049427
91Pathologic fracture (HP:0002756)1.97881919
92Polyneuropathy (HP:0001271)1.96117070
93Granulocytopenia (HP:0001913)1.95095664
94Colitis (HP:0002583)1.93567434
95Upper motor neuron abnormality (HP:0002127)1.93040524
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90776260
97Abnormality of polysaccharide metabolism (HP:0011012)1.90776260
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90776260
99Skin ulcer (HP:0200042)1.86951559
100Slow saccadic eye movements (HP:0000514)1.85378894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.66996303
2BLK4.49422343
3TYK23.38519848
4IRAK42.98247944
5MAP4K12.90921010
6MAP2K32.87870638
7CSK2.73760730
8ERN12.48648192
9JAK32.33839233
10FES2.25045770
11FGR2.17321813
12ZAP702.13269816
13MAP3K142.06152902
14TNK22.05270544
15TXK1.91756949
16IKBKE1.91595794
17SYK1.80825333
18TBK11.80339878
19JAK11.74703757
20CSF1R1.73099910
21KIT1.69236355
22BTK1.68061599
23TGFBR21.64906287
24LYN1.60641936
25GRK61.58975410
26MATK1.57400060
27JAK21.56718913
28HCK1.56172414
29MAP3K31.51461358
30MAP3K111.50875144
31MAP3K131.48282087
32TAOK11.48132583
33GRK71.41863164
34EPHB11.38358792
35IRAK31.31694815
36BMPR21.26284489
37PRPF4B1.22913884
38IKBKB1.22720488
39MAP3K61.22402777
40TAOK31.22302655
41LCK1.16954188
42MAP3K11.10251766
43CAMK1D1.09530091
44ITK1.04904358
45YES11.03996079
46TEC1.01998778
47IRAK10.97236124
48CDC42BPA0.92455794
49TAOK20.89574936
50MARK30.84007745
51PDK10.81645269
52MAP3K50.81451288
53IRAK20.79005795
54MARK20.78612825
55PDPK10.75560200
56KSR20.72834945
57STK100.69797001
58FGFR40.67117532
59FYN0.65433471
60PIK3CG0.64683010
61SIK30.62694966
62FGFR30.59217250
63MAP2K40.58999144
64MAPK120.58167973
65MAP2K60.58100148
66TESK20.58045885
67MOS0.57329698
68CDK60.55237994
69CAMK1G0.54855753
70EPHA30.53876357
71MAPK70.52825927
72PRKD20.51716938
73LRRK20.49160651
74CAMKK20.48475791
75RPS6KC10.47076888
76RPS6KL10.47076888
77CDK190.46826320
78PIM10.46347733
79PTK60.45374814
80ABL10.44697915
81MAPKAPK20.40427318
82PTK2B0.38975210
83RPS6KA60.38459377
84HIPK20.37826939
85RET0.37157495
86DMPK0.35719921
87PRKCD0.35715110
88CHUK0.35332464
89DAPK20.34554989
90SGK30.34455252
91CAMK40.34360397
92KSR10.34241171
93MAP3K70.33058696
94MAP3K20.33048523
95RIPK10.33006644
96SIK20.31123282
97PRKCQ0.30621511
98STK110.29530101
99EGFR0.28381265
100PRKG20.28095827

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.16558854
2Leishmaniasis_Homo sapiens_hsa051403.42032099
3Osteoclast differentiation_Homo sapiens_hsa043803.06896499
4Allograft rejection_Homo sapiens_hsa053302.78340780
5Graft-versus-host disease_Homo sapiens_hsa053322.64929114
6Autoimmune thyroid disease_Homo sapiens_hsa053202.53406877
7Tuberculosis_Homo sapiens_hsa051522.46646476
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45017082
9Asthma_Homo sapiens_hsa053102.22952868
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14649852
11Type I diabetes mellitus_Homo sapiens_hsa049402.11803858
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10048555
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08178437
14Antigen processing and presentation_Homo sapiens_hsa046121.99749906
15Phagosome_Homo sapiens_hsa041451.94094626
16Other glycan degradation_Homo sapiens_hsa005111.93056358
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92250984
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.90952970
19Legionellosis_Homo sapiens_hsa051341.89713101
20Rheumatoid arthritis_Homo sapiens_hsa053231.84222350
21B cell receptor signaling pathway_Homo sapiens_hsa046621.78907643
22Malaria_Homo sapiens_hsa051441.78902790
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70738526
24Influenza A_Homo sapiens_hsa051641.66857281
25Viral myocarditis_Homo sapiens_hsa054161.65566517
26Lysosome_Homo sapiens_hsa041421.65429577
27Pertussis_Homo sapiens_hsa051331.63622038
28Hematopoietic cell lineage_Homo sapiens_hsa046401.62678320
29Toxoplasmosis_Homo sapiens_hsa051451.61798139
30Chemokine signaling pathway_Homo sapiens_hsa040621.60091415
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.59519524
32Measles_Homo sapiens_hsa051621.52950315
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38261040
34Primary immunodeficiency_Homo sapiens_hsa053401.34070704
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32870426
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29697457
37Herpes simplex infection_Homo sapiens_hsa051681.29284263
38TNF signaling pathway_Homo sapiens_hsa046681.21707675
39African trypanosomiasis_Homo sapiens_hsa051431.15711202
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14788931
41Salmonella infection_Homo sapiens_hsa051321.13777191
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.08721657
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.07278875
44Acute myeloid leukemia_Homo sapiens_hsa052211.05199530
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04263066
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99941551
47T cell receptor signaling pathway_Homo sapiens_hsa046600.97348572
48Hepatitis C_Homo sapiens_hsa051600.93408277
49Hepatitis B_Homo sapiens_hsa051610.90722187
50Platelet activation_Homo sapiens_hsa046110.88101282
51Complement and coagulation cascades_Homo sapiens_hsa046100.87370801
52Shigellosis_Homo sapiens_hsa051310.85728119
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82279939
54Apoptosis_Homo sapiens_hsa042100.80206321
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.78528095
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76914504
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75259492
58Collecting duct acid secretion_Homo sapiens_hsa049660.65712963
59Non-small cell lung cancer_Homo sapiens_hsa052230.65467700
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62608874
61Prolactin signaling pathway_Homo sapiens_hsa049170.62431239
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61191674
63Pancreatic cancer_Homo sapiens_hsa052120.60496360
64Amoebiasis_Homo sapiens_hsa051460.59907788
65Systemic lupus erythematosus_Homo sapiens_hsa053220.58610074
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.58398796
67Prion diseases_Homo sapiens_hsa050200.57469201
68VEGF signaling pathway_Homo sapiens_hsa043700.56974527
69Endocytosis_Homo sapiens_hsa041440.53551311
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53174520
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52246667
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52156290
73Epstein-Barr virus infection_Homo sapiens_hsa051690.50816551
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.49821100
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.46792721
76Notch signaling pathway_Homo sapiens_hsa043300.46392902
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.44632013
78Chronic myeloid leukemia_Homo sapiens_hsa052200.44523912
79Renal cell carcinoma_Homo sapiens_hsa052110.43452624
80HIF-1 signaling pathway_Homo sapiens_hsa040660.43433667
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42581257
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39684070
83HTLV-I infection_Homo sapiens_hsa051660.39178763
84Dorso-ventral axis formation_Homo sapiens_hsa043200.39010871
85GnRH signaling pathway_Homo sapiens_hsa049120.36973771
86Viral carcinogenesis_Homo sapiens_hsa052030.36188415
87Galactose metabolism_Homo sapiens_hsa000520.35704818
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30601297
89FoxO signaling pathway_Homo sapiens_hsa040680.30559303
90Type II diabetes mellitus_Homo sapiens_hsa049300.29882520
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24168816
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23618309
93MAPK signaling pathway_Homo sapiens_hsa040100.23211744
94Rap1 signaling pathway_Homo sapiens_hsa040150.21311970
95Choline metabolism in cancer_Homo sapiens_hsa052310.19257504
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19098813
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18786354
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.17304729
99Insulin resistance_Homo sapiens_hsa049310.16204641
100Bladder cancer_Homo sapiens_hsa052190.16012499

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