FCGR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)8.59015129
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.78549753
3activation of protein kinase A activity (GO:0034199)5.25931565
4cAMP biosynthetic process (GO:0006171)4.96556004
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63897496
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.63897496
7modulation by symbiont of host immune response (GO:0052553)4.63897496
8positive regulation by symbiont of host defense response (GO:0052509)4.63897496
9modulation by symbiont of host defense response (GO:0052031)4.63897496
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63897496
11replicative senescence (GO:0090399)4.59712487
12regulation of DNA damage checkpoint (GO:2000001)4.58791697
13macrophage activation involved in immune response (GO:0002281)4.29548082
14detection of molecule of bacterial origin (GO:0032490)4.20658976
15protein prenylation (GO:0018342)3.96023529
16prenylation (GO:0097354)3.96023529
17regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.96008838
18negative regulation of T-helper cell differentiation (GO:0045623)3.91383273
19negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.91383273
20microglial cell activation (GO:0001774)3.81843991
21positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.73523833
22DNA integration (GO:0015074)3.64453187
23cellular extravasation (GO:0045123)3.62007806
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61176981
25viral mRNA export from host cell nucleus (GO:0046784)3.53529770
26regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.49719219
27macrophage activation (GO:0042116)3.48577741
28interferon-gamma production (GO:0032609)3.47954108
29hematopoietic stem cell proliferation (GO:0071425)3.46941542
30dendritic spine morphogenesis (GO:0060997)3.42005368
31regulation of T-helper 2 cell differentiation (GO:0045628)3.32388768
32negative regulation of interleukin-12 production (GO:0032695)3.32224940
33negative regulation of actin filament bundle assembly (GO:0032232)3.30933308
34positive regulation of gamma-delta T cell activation (GO:0046645)3.15907791
35regulation of activation of Janus kinase activity (GO:0010533)3.14379053
36detection of external biotic stimulus (GO:0098581)3.11592702
37negative regulation of type 2 immune response (GO:0002829)3.11581331
38post-anal tail morphogenesis (GO:0036342)3.11501310
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09407136
40response to host immune response (GO:0052572)3.09407136
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04229128
42response to peptidoglycan (GO:0032494)3.00158707
43interferon-gamma secretion (GO:0072643)2.99752695
44regulation of B cell receptor signaling pathway (GO:0050855)2.93219053
45neutrophil activation involved in immune response (GO:0002283)2.92722226
46growth hormone receptor signaling pathway (GO:0060396)2.88708596
47neutrophil mediated immunity (GO:0002446)2.88108779
48carnitine shuttle (GO:0006853)2.87518327
49regulation of skeletal muscle contraction (GO:0014819)2.86870342
50germinal center formation (GO:0002467)2.82991573
51positive regulation of mast cell activation (GO:0033005)2.82615016
52positive regulation of systemic arterial blood pressure (GO:0003084)2.80003995
53righting reflex (GO:0060013)2.79491691
54cellular response to epinephrine stimulus (GO:0071872)2.79442214
55cAMP metabolic process (GO:0046058)2.79188429
56negative regulation of catenin import into nucleus (GO:0035414)2.78437978
57response to host (GO:0075136)2.77732915
58response to host defenses (GO:0052200)2.77732915
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77732915
60regulation of interferon-beta biosynthetic process (GO:0045357)2.76149868
61response to epinephrine (GO:0071871)2.75321494
62positive regulation of interferon-beta production (GO:0032728)2.74169605
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73697215
64positive regulation of interferon-alpha production (GO:0032727)2.73679771
65detection of other organism (GO:0098543)2.73568888
66detection of biotic stimulus (GO:0009595)2.73471654
67negative regulation of cell killing (GO:0031342)2.69439273
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69439273
69regulation of germinal center formation (GO:0002634)2.68158026
70regulation of gamma-delta T cell activation (GO:0046643)2.67496699
71regulation of interferon-alpha production (GO:0032647)2.65263753
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63325675
73regulation of sequestering of triglyceride (GO:0010889)2.63278793
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62882040
75relaxation of cardiac muscle (GO:0055119)2.62107528
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61096543
77production of molecular mediator involved in inflammatory response (GO:0002532)2.59946197
78cellular response to ethanol (GO:0071361)2.59626972
79membrane protein ectodomain proteolysis (GO:0006509)2.58575049
80response to inactivity (GO:0014854)2.55157371
81tooth mineralization (GO:0034505)2.54516035
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54264670
83cellular response to growth hormone stimulus (GO:0071378)2.54130685
84regulation of T-helper 1 cell differentiation (GO:0045625)2.52998678
85cardiac muscle hypertrophy (GO:0003300)2.52724676
86positive regulation of RNA splicing (GO:0033120)2.51941155
87myeloid cell activation involved in immune response (GO:0002275)2.49018658
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48851724
89regulation of lymphocyte chemotaxis (GO:1901623)2.47937980
90negative regulation of alpha-beta T cell differentiation (GO:0046639)2.47685373
91regulation of gamma-delta T cell differentiation (GO:0045586)2.46856299
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.45662120
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44408603
94positive regulation of mast cell degranulation (GO:0043306)2.43797635
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.43797635
96water transport (GO:0006833)2.43395311
97spleen development (GO:0048536)2.42139161
98regulation of endothelial cell differentiation (GO:0045601)2.39225118
99T cell mediated immunity (GO:0002456)2.39174263
100striated muscle hypertrophy (GO:0014897)2.37327875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.92485067
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.38392415
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32656742
4GATA1_22025678_ChIP-Seq_K562_Human2.80937695
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.69977389
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68623052
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.49016898
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44138585
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41615158
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.40823870
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30167378
12TP53_16413492_ChIP-PET_HCT116_Human2.13210015
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06572951
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.05516266
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99790090
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.95864418
17RUNX_20019798_ChIP-Seq_JUKART_Human1.85491824
18VDR_24763502_ChIP-Seq_THP-1_Human1.78550474
19SCL_19346495_ChIP-Seq_HPC-7_Human1.77354970
20GATA1_19941826_ChIP-Seq_K562_Human1.76692371
21VDR_24787735_ChIP-Seq_THP-1_Human1.74570227
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73267042
23AR_21572438_ChIP-Seq_LNCaP_Human1.70260916
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65156709
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51530031
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50925104
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48088472
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44409660
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42424068
30VDR_21846776_ChIP-Seq_THP-1_Human1.37886590
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37860428
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37465926
33GATA2_19941826_ChIP-Seq_K562_Human1.37239378
34SPI1_23127762_ChIP-Seq_K562_Human1.33911910
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.32534965
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26408814
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26248551
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25814664
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.24425820
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23506704
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21294165
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20989812
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19885321
44* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19715952
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19568734
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19119674
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18892967
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.18661837
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17833142
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16304639
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13682685
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13565179
53TCF7_22412390_ChIP-Seq_EML_Mouse1.13224408
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12845123
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12159498
56MYB_26560356_Chip-Seq_TH2_Human1.09378607
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09129793
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07268182
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.05257051
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03746859
61PU_27001747_Chip-Seq_BMDM_Mouse1.02501282
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02040009
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01901019
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.00684874
65KDM2B_26808549_Chip-Seq_DND41_Human1.00540209
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00092603
67RUNX1_22412390_ChIP-Seq_EML_Mouse0.96625248
68NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96557585
69MYB_26560356_Chip-Seq_TH1_Human0.96038282
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96001022
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94879672
72DROSHA_22980978_ChIP-Seq_HELA_Human0.94318980
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92120480
74TBX20_22328084_ChIP-Seq_HEART_Mouse0.91657319
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.91657319
76RXR_22108803_ChIP-Seq_LS180_Human0.91480556
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90898194
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89085650
79CJUN_26792858_Chip-Seq_BT549_Human0.88681407
80UTX_26944678_Chip-Seq_JUKART_Human0.88304089
81GF1_26923725_Chip-Seq_HPCs_Mouse0.88044601
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86678292
83LXR_22158963_ChIP-Seq_LIVER_Mouse0.86573914
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85859891
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84876951
86MAF_26560356_Chip-Seq_TH1_Human0.82987797
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82926306
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82359118
89* GATA3_27048872_Chip-Seq_THYMUS_Human0.81691201
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81350224
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79621018
92ESR1_20079471_ChIP-ChIP_T-47D_Human0.78246215
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76798994
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75729699
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75673595
96* SPI1_23547873_ChIP-Seq_NB4_Human0.74578805
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.73841992
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.73396865
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72995425
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72604125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.53098942
2MP0003303_peritoneal_inflammation3.22176559
3MP0003183_abnormal_peptide_metabolism3.16464195
4MP0004510_myositis3.02553830
5MP0004130_abnormal_muscle_cell2.82521689
6MP0009764_decreased_sensitivity_to2.79269958
7MP0003436_decreased_susceptibility_to2.70745160
8MP0005409_darkened_coat_color2.53969804
9MP0005451_abnormal_body_composition2.48420585
10MP0003828_pulmonary_edema2.38452454
11MP0003221_abnormal_cardiomyocyte_apopto2.29599805
12MP0000751_myopathy2.28308805
13MP0003646_muscle_fatigue2.27453195
14MP0002419_abnormal_innate_immunity2.22166347
15MP0002009_preneoplasia2.08465874
16MP0001800_abnormal_humoral_immune2.05393676
17MP0000750_abnormal_muscle_regeneration2.01694711
18MP0005000_abnormal_immune_tolerance1.95059104
19MP0009785_altered_susceptibility_to1.90673359
20MP0002452_abnormal_antigen_presenting1.90379126
21MP0001835_abnormal_antigen_presentation1.83067528
22MP0004484_altered_response_of1.81884231
23MP0005025_abnormal_response_to1.73108547
24MP0002723_abnormal_immune_serum1.71841571
25MP0001790_abnormal_immune_system1.70355318
26MP0005387_immune_system_phenotype1.70355318
27MP0002332_abnormal_exercise_endurance1.70159265
28MP0002148_abnormal_hypersensitivity_rea1.68998550
29MP0005084_abnormal_gallbladder_morpholo1.67522402
30MP0005671_abnormal_response_to1.66801547
31MP0002420_abnormal_adaptive_immunity1.62496841
32MP0001819_abnormal_immune_cell1.60035271
33MP0002163_abnormal_gland_morphology1.59993495
34MP0000343_altered_response_to1.50291437
35MP0003300_gastrointestinal_ulcer1.48435718
36MP0002972_abnormal_cardiac_muscle1.37402449
37MP0001533_abnormal_skeleton_physiology1.36812735
38MP0005464_abnormal_platelet_physiology1.35940464
39MP0002998_abnormal_bone_remodeling1.34935408
40MP0004215_abnormal_myocardial_fiber1.32479340
41MP0002405_respiratory_system_inflammati1.31858256
42MP0004084_abnormal_cardiac_muscle1.31145636
43MP0000465_gastrointestinal_hemorrhage1.29999114
44MP0006138_congestive_heart_failure1.29920593
45MP0001845_abnormal_inflammatory_respons1.29763486
46MP0008004_abnormal_stomach_pH1.28954805
47MP0000685_abnormal_immune_system1.27903508
48MP0004947_skin_inflammation1.23429437
49MP0000371_diluted_coat_color1.23259446
50MP0002127_abnormal_cardiovascular_syste1.22087935
51MP0005167_abnormal_blood-brain_barrier1.21589289
52MP0002166_altered_tumor_susceptibility1.21282214
53MP0000749_muscle_degeneration1.19266831
54MP0005166_decreased_susceptibility_to1.17271388
55MP0003191_abnormal_cellular_cholesterol1.14782349
56MP0005164_abnormal_response_to1.13891784
57MP0003656_abnormal_erythrocyte_physiolo1.13212482
58MP0008469_abnormal_protein_level1.12441037
59MP0000716_abnormal_immune_system1.11422098
60MP0003705_abnormal_hypodermis_morpholog1.10959050
61MP0009115_abnormal_fat_cell1.10124406
62MP0002106_abnormal_muscle_physiology1.07524812
63MP0005385_cardiovascular_system_phenoty1.07419568
64MP0001544_abnormal_cardiovascular_syste1.07419568
65MP0009278_abnormal_bone_marrow1.07215731
66MP0000747_muscle_weakness1.06590733
67MP0010155_abnormal_intestine_physiology1.05642602
68MP0003690_abnormal_glial_cell1.05488296
69MP0002877_abnormal_melanocyte_morpholog1.03306364
70MP0002398_abnormal_bone_marrow0.99895165
71MP0003252_abnormal_bile_duct0.97910718
72MP0003453_abnormal_keratinocyte_physiol0.95387886
73MP0005379_endocrine/exocrine_gland_phen0.93044159
74MP0001661_extended_life_span0.92378975
75MP0003045_fibrosis0.91058347
76MP0002722_abnormal_immune_system0.90697612
77MP0004883_abnormal_blood_vessel0.90642764
78MP0004087_abnormal_muscle_fiber0.90367471
79MP0002006_tumorigenesis0.89518815
80MP0004036_abnormal_muscle_relaxation0.89501855
81MP0002971_abnormal_brown_adipose0.87522672
82MP0006082_CNS_inflammation0.86538778
83MP0003075_altered_response_to0.85807475
84MP0001545_abnormal_hematopoietic_system0.85802531
85MP0005397_hematopoietic_system_phenotyp0.85802531
86MP0000689_abnormal_spleen_morphology0.84354548
87MP0005369_muscle_phenotype0.82628305
88MP0000569_abnormal_digit_pigmentation0.82473952
89MP0010368_abnormal_lymphatic_system0.82252534
90MP0005165_increased_susceptibility_to0.81447252
91MP0005620_abnormal_muscle_contractility0.81356203
92MP0002429_abnormal_blood_cell0.80445563
93MP0002277_abnormal_respiratory_mucosa0.80332625
94MP0005334_abnormal_fat_pad0.79524088
95MP0009840_abnormal_foam_cell0.78369155
96MP0003763_abnormal_thymus_physiology0.78297727
97MP0000249_abnormal_blood_vessel0.77870550
98MP0004185_abnormal_adipocyte_glucose0.77690444
99MP0002269_muscular_atrophy0.77588609
100MP0005275_abnormal_skin_tensile0.77076351

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)8.51802500
2Anomalous pulmonary venous return (HP:0010772)7.77339394
3Abnormality of the pulmonary veins (HP:0011718)6.85495196
4Muscle fibrillation (HP:0010546)5.39307481
5Slow saccadic eye movements (HP:0000514)5.35945526
6Hemiplegia (HP:0002301)5.17088357
7Tongue fasciculations (HP:0001308)5.09284162
8Pathologic fracture (HP:0002756)3.98783893
9Abnormality of the odontoid process (HP:0003310)3.66880612
10Hyporeflexia of lower limbs (HP:0002600)3.64991148
11Recurrent bacterial skin infections (HP:0005406)3.57621448
12Eczematoid dermatitis (HP:0000976)3.28573074
13Syncope (HP:0001279)3.15619486
14Muscle fiber splitting (HP:0003555)3.13574711
15Recurrent abscess formation (HP:0002722)3.07845342
16J-shaped sella turcica (HP:0002680)3.05323184
17Short femoral neck (HP:0100864)3.03276750
18Recurrent gram-negative bacterial infections (HP:0005420)3.03199291
19Abnormality of glycosphingolipid metabolism (HP:0004343)2.93243066
20Abnormality of glycolipid metabolism (HP:0010969)2.93243066
21Abnormality of liposaccharide metabolism (HP:0010968)2.93243066
22Abnormality of the intervertebral disk (HP:0005108)2.90790538
23Difficulty running (HP:0009046)2.89463643
24Myelomeningocele (HP:0002475)2.77341632
25Right ventricular cardiomyopathy (HP:0011663)2.77341231
26Ventricular arrhythmia (HP:0004308)2.76873567
27Orchitis (HP:0100796)2.73377714
28Rough bone trabeculation (HP:0100670)2.73184128
29Distal lower limb muscle weakness (HP:0009053)2.72648034
30Bundle branch block (HP:0011710)2.71348886
31Keratoconjunctivitis sicca (HP:0001097)2.71216608
32Myositis (HP:0100614)2.70626283
33Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.63089993
34Retrobulbar optic neuritis (HP:0100654)2.62777295
35Optic neuritis (HP:0100653)2.62777295
36Decreased circulating renin level (HP:0003351)2.57319843
37Impaired smooth pursuit (HP:0007772)2.53306105
38Ventricular tachycardia (HP:0004756)2.47426950
39Abnormality of macrophages (HP:0004311)2.46260490
40Ventricular fibrillation (HP:0001663)2.42795015
41Keratoconjunctivitis (HP:0001096)2.39956393
42Premature graying of hair (HP:0002216)2.36196357
43Deformed sella turcica (HP:0002681)2.33760844
44Subacute progressive viral hepatitis (HP:0006572)2.31668932
45Vertebral arch anomaly (HP:0008438)2.29565091
46Spontaneous hematomas (HP:0007420)2.26531658
47Stomatitis (HP:0010280)2.25238843
48Oligodontia (HP:0000677)2.24142425
49Morphological abnormality of the pyramidal tract (HP:0002062)2.22318527
50Atrial fibrillation (HP:0005110)2.20505520
51Calf muscle hypertrophy (HP:0008981)2.16956829
52Sudden death (HP:0001699)2.16254726
53Gastrointestinal infarctions (HP:0005244)2.15073663
54Aplasia/hypoplasia of the femur (HP:0005613)2.13395203
55Gingivitis (HP:0000230)2.11553737
56Polycythemia (HP:0001901)2.06344683
57Prominent occiput (HP:0000269)2.05007126
58Palpitations (HP:0001962)2.03799749
59Abnormality of saccadic eye movements (HP:0000570)2.02696880
60Amelogenesis imperfecta (HP:0000705)2.01631792
61Mediastinal lymphadenopathy (HP:0100721)1.99746653
62Abnormality of ocular smooth pursuit (HP:0000617)1.99171647
63Abnormality of the lumbar spine (HP:0100712)1.98863446
64Arterial thrombosis (HP:0004420)1.98137802
65Increased connective tissue (HP:0009025)1.97431180
66Thoracolumbar scoliosis (HP:0002944)1.96456514
67EMG: myopathic abnormalities (HP:0003458)1.95619608
68Urticaria (HP:0001025)1.95063758
69Muscle hypertrophy of the lower extremities (HP:0008968)1.93870804
70Abnormal trabecular bone morphology (HP:0100671)1.93718017
71Aseptic necrosis (HP:0010885)1.93423809
72Vertigo (HP:0002321)1.93333668
73Primary atrial arrhythmia (HP:0001692)1.90482691
74Areflexia of lower limbs (HP:0002522)1.88162910
75Recurrent skin infections (HP:0001581)1.86909287
76Vertebral fusion (HP:0002948)1.86134900
77Supraventricular tachycardia (HP:0004755)1.81045861
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78945827
79Tinnitus (HP:0000360)1.78514516
80Myocardial infarction (HP:0001658)1.77176428
81Disinhibition (HP:0000734)1.77163035
82Hypermelanotic macule (HP:0001034)1.75468969
83Aortic regurgitation (HP:0001659)1.75211973
84Supraventricular arrhythmia (HP:0005115)1.73602481
85Diastasis recti (HP:0001540)1.72776357
86Palmoplantar keratoderma (HP:0000982)1.68247857
87Broad ribs (HP:0000885)1.67901436
88Flared iliac wings (HP:0002869)1.66819615
89Esophageal varix (HP:0002040)1.65954462
90Persistence of primary teeth (HP:0006335)1.65947527
91Abnormality of the calf musculature (HP:0001430)1.65707814
92Recurrent fungal infections (HP:0002841)1.65294611
93Thickened calvaria (HP:0002684)1.65080917
94Asymmetric septal hypertrophy (HP:0001670)1.63589347
95Mutism (HP:0002300)1.61960408
96Elevated erythrocyte sedimentation rate (HP:0003565)1.61757999
97Chronic obstructive pulmonary disease (HP:0006510)1.61598729
98Obstructive lung disease (HP:0006536)1.61598729
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.61073886
100Chest pain (HP:0100749)1.60811976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.60566051
2IRAK33.41033814
3* BLK3.28744333
4MAP2K42.86776449
5MAP2K72.80953461
6MAP3K42.71943775
7PRPF4B2.44853470
8TGFBR22.44234466
9RIPK42.43340788
10IRAK42.27312640
11MAP2K32.22290818
12CSK2.12284277
13MAP4K11.84974924
14GRK71.72454216
15MAP3K31.63115917
16MAP3K61.61616371
17CAMK41.53182695
18STK241.53084922
19MAP3K21.50032058
20STK41.45019795
21TAOK11.42377253
22ZAP701.41274184
23TAOK31.40493579
24GRK61.38435576
25RIPK11.33060217
26HCK1.29461571
27TTN1.29374630
28JAK21.25774332
29ZAK1.23960724
30JAK31.21484714
31OBSCN1.14576800
32* SYK1.11695935
33MAPK121.11387093
34CAMK1D1.11320807
35MAP3K71.09306280
36IKBKE1.09226831
37NEK91.06963557
38MOS1.06409558
39MAP3K11.05746344
40PIM11.03954620
41KSR21.03232089
42FES0.99061586
43RPS6KA60.98766770
44SGK20.98579011
45TYK20.98449732
46RPS6KL10.98039295
47RPS6KC10.98039295
48RET0.97520540
49TRPM70.96769843
50PIK3CG0.93277481
51MATK0.91997944
52MAP3K140.91447345
53MARK20.90939596
54PDGFRB0.88980467
55CAMKK20.88894360
56HIPK20.87971496
57YES10.87030474
58PRKAA20.85046733
59TRIB30.84295602
60STK110.82690393
61PDK10.82371512
62MAP3K50.82311883
63TXK0.82064558
64SGK30.81120300
65STK30.81083147
66MAP3K110.79494378
67PKN20.79431220
68EPHA30.79412935
69* LYN0.75528666
70MAPK70.74219771
71MAPK40.71884949
72BMPR20.70342153
73JAK10.69983997
74PDPK10.68925246
75MAP3K90.66061687
76FGR0.65908196
77FRK0.63148285
78BTK0.61353800
79WNK10.60937956
80GRK50.60681665
81STK100.60322935
82TAOK20.59101011
83IKBKB0.57815174
84TBK10.56186001
85NTRK20.55731635
86PTK2B0.53633377
87PRKD10.50631749
88DAPK20.50402026
89SGK4940.49880575
90SGK2230.49880575
91FGFR30.49520721
92ITK0.48360733
93PKN10.46303659
94DAPK30.42282004
95IRAK10.41446728
96LCK0.41202293
97ADRBK20.41193810
98CDC42BPA0.40247638
99RPS6KA20.40113136
100PRKAA10.38478529

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053222.18675231
2* Osteoclast differentiation_Homo sapiens_hsa043802.10976624
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.08506274
4Dilated cardiomyopathy_Homo sapiens_hsa054141.97250777
5Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.90999398
6* Staphylococcus aureus infection_Homo sapiens_hsa051501.79414454
7* Leishmaniasis_Homo sapiens_hsa051401.77774295
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77700550
9GnRH signaling pathway_Homo sapiens_hsa049121.75165387
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59326311
11Malaria_Homo sapiens_hsa051441.54936106
12Ovarian steroidogenesis_Homo sapiens_hsa049131.54855107
13Chemokine signaling pathway_Homo sapiens_hsa040621.52690746
14* Tuberculosis_Homo sapiens_hsa051521.46695059
15TNF signaling pathway_Homo sapiens_hsa046681.44315768
16B cell receptor signaling pathway_Homo sapiens_hsa046621.44185730
17* Platelet activation_Homo sapiens_hsa046111.37784922
18Dorso-ventral axis formation_Homo sapiens_hsa043201.37442735
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35927771
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.31469812
21Influenza A_Homo sapiens_hsa051641.29102050
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28275789
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.26777706
24Alcoholism_Homo sapiens_hsa050341.25036397
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24933869
26* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23426592
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23248541
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16540938
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16445005
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.15935387
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.13650848
32T cell receptor signaling pathway_Homo sapiens_hsa046601.13611011
33Sulfur metabolism_Homo sapiens_hsa009201.13457513
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10202675
35Toxoplasmosis_Homo sapiens_hsa051451.10030983
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08749040
37Acute myeloid leukemia_Homo sapiens_hsa052211.06212206
38Gastric acid secretion_Homo sapiens_hsa049711.03315877
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02123158
40Viral carcinogenesis_Homo sapiens_hsa052031.01933692
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.01385821
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01067229
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00456271
44Estrogen signaling pathway_Homo sapiens_hsa049150.99739507
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98976944
46Insulin resistance_Homo sapiens_hsa049310.97433677
47Prolactin signaling pathway_Homo sapiens_hsa049170.97333921
48Measles_Homo sapiens_hsa051620.94780311
49Morphine addiction_Homo sapiens_hsa050320.92711201
50FoxO signaling pathway_Homo sapiens_hsa040680.91578508
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91470891
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91181089
53Gap junction_Homo sapiens_hsa045400.91129484
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89110984
55Pancreatic secretion_Homo sapiens_hsa049720.87971795
56Type II diabetes mellitus_Homo sapiens_hsa049300.87509698
57Renal cell carcinoma_Homo sapiens_hsa052110.86677344
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.86342303
59Cholinergic synapse_Homo sapiens_hsa047250.85004031
60cAMP signaling pathway_Homo sapiens_hsa040240.84950807
61Non-small cell lung cancer_Homo sapiens_hsa052230.84166932
62Oxytocin signaling pathway_Homo sapiens_hsa049210.82637462
63Hepatitis C_Homo sapiens_hsa051600.82630561
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.82157259
65Legionellosis_Homo sapiens_hsa051340.82126367
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78255015
67Olfactory transduction_Homo sapiens_hsa047400.78183095
68Hepatitis B_Homo sapiens_hsa051610.77861326
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77594752
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77330485
71Salivary secretion_Homo sapiens_hsa049700.76481030
72ErbB signaling pathway_Homo sapiens_hsa040120.72871972
73Pancreatic cancer_Homo sapiens_hsa052120.72439140
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71787761
75Viral myocarditis_Homo sapiens_hsa054160.70896989
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70797365
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70706706
78Bladder cancer_Homo sapiens_hsa052190.70315218
79Bile secretion_Homo sapiens_hsa049760.69557601
80Renin secretion_Homo sapiens_hsa049240.69234334
81MAPK signaling pathway_Homo sapiens_hsa040100.69202128
82Pertussis_Homo sapiens_hsa051330.69016850
83Hematopoietic cell lineage_Homo sapiens_hsa046400.68038449
84Apoptosis_Homo sapiens_hsa042100.67848809
85Other glycan degradation_Homo sapiens_hsa005110.67619539
86Rap1 signaling pathway_Homo sapiens_hsa040150.67249753
87Calcium signaling pathway_Homo sapiens_hsa040200.65728373
88Insulin secretion_Homo sapiens_hsa049110.65629888
89Amoebiasis_Homo sapiens_hsa051460.65512724
90Herpes simplex infection_Homo sapiens_hsa051680.65000238
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64186546
92Choline metabolism in cancer_Homo sapiens_hsa052310.63252740
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63097994
94African trypanosomiasis_Homo sapiens_hsa051430.61276712
95Graft-versus-host disease_Homo sapiens_hsa053320.61178517
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60240158
97mTOR signaling pathway_Homo sapiens_hsa041500.59064341
98Complement and coagulation cascades_Homo sapiens_hsa046100.57987968
99Rheumatoid arthritis_Homo sapiens_hsa053230.55477559
100VEGF signaling pathway_Homo sapiens_hsa043700.54921945

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