FCGR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.78307304
2positive regulation by symbiont of host defense response (GO:0052509)5.63104039
3modulation by symbiont of host defense response (GO:0052031)5.63104039
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.63104039
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.63104039
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.63104039
7modulation by symbiont of host immune response (GO:0052553)5.63104039
8neutrophil activation involved in immune response (GO:0002283)5.35097499
9macrophage activation involved in immune response (GO:0002281)4.89378742
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80254466
11negative regulation of cell killing (GO:0031342)4.80254466
12response to peptidoglycan (GO:0032494)4.71837549
13microglial cell activation (GO:0001774)4.61131566
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.58667694
15regulation of interferon-beta biosynthetic process (GO:0045357)4.46791613
16respiratory burst (GO:0045730)4.45509903
17detection of bacterium (GO:0016045)4.23053253
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21332648
19regulation of gamma-delta T cell activation (GO:0046643)4.14314982
20antigen processing and presentation of endogenous antigen (GO:0019883)4.10023485
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02694174
22positive regulation of cellular amide metabolic process (GO:0034250)3.98550722
23granulocyte activation (GO:0036230)3.86191449
24superoxide anion generation (GO:0042554)3.82687240
25neutrophil activation (GO:0042119)3.82052987
26interferon-gamma-mediated signaling pathway (GO:0060333)3.77595047
27macrophage activation (GO:0042116)3.75002243
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73979320
29cellular extravasation (GO:0045123)3.70743665
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70058529
31response to host immune response (GO:0052572)3.70058529
32immunoglobulin mediated immune response (GO:0016064)3.65730731
33type I interferon signaling pathway (GO:0060337)3.65482871
34cellular response to type I interferon (GO:0071357)3.65482871
35detection of biotic stimulus (GO:0009595)3.64146101
36response to type I interferon (GO:0034340)3.63349093
37production of molecular mediator involved in inflammatory response (GO:0002532)3.58550172
38myeloid cell activation involved in immune response (GO:0002275)3.54061551
39positive regulation of interferon-alpha production (GO:0032727)3.51663647
40regulation of B cell receptor signaling pathway (GO:0050855)3.50617202
41B cell mediated immunity (GO:0019724)3.49963445
42positive regulation of monocyte chemotaxis (GO:0090026)3.48708515
43hydrogen peroxide biosynthetic process (GO:0050665)3.46211788
44defense response to protozoan (GO:0042832)3.45800645
45positive regulation of mast cell degranulation (GO:0043306)3.44672365
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.44672365
47regulation of gamma-delta T cell differentiation (GO:0045586)3.43787700
48positive regulation of B cell differentiation (GO:0045579)3.42707227
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36498804
50regulation of interferon-alpha production (GO:0032647)3.35285087
51positive regulation of mast cell activation (GO:0033005)3.34616005
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.32499697
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.29835594
54positive regulation of antigen processing and presentation (GO:0002579)3.29634363
55detection of molecule of bacterial origin (GO:0032490)3.27896401
56regulation of interleukin-8 biosynthetic process (GO:0045414)3.27823635
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26455006
58response to protozoan (GO:0001562)3.25940759
59regulation of mast cell degranulation (GO:0043304)3.25099223
60reactive oxygen species biosynthetic process (GO:1903409)3.24220713
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23393597
62regulation of T-helper 2 cell differentiation (GO:0045628)3.22415384
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21701446
64response to host (GO:0075136)3.21701446
65response to host defenses (GO:0052200)3.21701446
66pinocytosis (GO:0006907)3.09083267
67neutrophil mediated immunity (GO:0002446)3.08740005
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08450430
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.08176460
70negative regulation of T cell mediated immunity (GO:0002710)3.07734478
71I-kappaB phosphorylation (GO:0007252)3.06650683
72regulation of mononuclear cell migration (GO:0071675)3.06287728
73N-acetylneuraminate metabolic process (GO:0006054)3.04996387
74negative regulation of interleukin-12 production (GO:0032695)3.04709750
75lipoxygenase pathway (GO:0019372)3.03099969
76regulation of B cell differentiation (GO:0045577)3.01963258
77negative regulation of leukocyte mediated immunity (GO:0002704)3.01185580
78positive regulation of type 2 immune response (GO:0002830)3.00338836
79regulation of mast cell activation (GO:0033003)2.98533122
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97690814
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97503847
82regulation of mast cell activation involved in immune response (GO:0033006)2.96685441
83positive thymic T cell selection (GO:0045059)2.96058902
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91674291
85cellular response to interferon-gamma (GO:0071346)2.90670032
86amino sugar catabolic process (GO:0046348)2.89548741
87response to muramyl dipeptide (GO:0032495)2.88191884
88T-helper 1 type immune response (GO:0042088)2.87406864
89positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87318861
90regulation of T cell tolerance induction (GO:0002664)2.86821028
91eosinophil chemotaxis (GO:0048245)2.85584748
92myeloid dendritic cell differentiation (GO:0043011)2.85028281
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81710134
94negative regulation of cytokine production involved in immune response (GO:0002719)2.80998784
95neutrophil chemotaxis (GO:0030593)2.80571318
96myeloid dendritic cell activation (GO:0001773)2.80331798
97positive regulation of lymphocyte migration (GO:2000403)2.79460663
98regulation of antigen processing and presentation (GO:0002577)2.79247130
99regulation of monocyte chemotaxis (GO:0090025)2.78840047
100NIK/NF-kappaB signaling (GO:0038061)2.78696070
101negative regulation of erythrocyte differentiation (GO:0045647)2.77178636
102detection of other organism (GO:0098543)2.76911896
103regulation of platelet activation (GO:0010543)2.76109107
104negative regulation of interleukin-17 production (GO:0032700)2.75062094
105regulation of lymphocyte chemotaxis (GO:1901623)2.74996518
106neutrophil migration (GO:1990266)2.73530447
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73148773
108regulation of tolerance induction (GO:0002643)2.72546073
109G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71559325
110positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.71474200
111positive regulation of leukocyte degranulation (GO:0043302)2.71171417
112eosinophil migration (GO:0072677)2.71068419
113myeloid leukocyte activation (GO:0002274)2.70883407
114response to interferon-gamma (GO:0034341)2.70678968
115regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70370587
116positive regulation of acute inflammatory response (GO:0002675)2.69809658
117positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68972047
118complement activation, alternative pathway (GO:0006957)2.67288527
119lymphocyte chemotaxis (GO:0048247)2.66697378
120detection of external biotic stimulus (GO:0098581)2.66546693
121regulation of leukocyte degranulation (GO:0043300)2.65964804
122T cell migration (GO:0072678)2.64599781
123leukotriene metabolic process (GO:0006691)2.63044739
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.60815560
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.60620809
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59487253
127regulation of lymphocyte migration (GO:2000401)2.59323323
128granulocyte chemotaxis (GO:0071621)2.59221602
129leukocyte mediated cytotoxicity (GO:0001909)2.59107427
130germinal center formation (GO:0002467)2.58033980
131positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57458247
132monocyte chemotaxis (GO:0002548)2.57005267
133leukocyte aggregation (GO:0070486)2.56185947
134leukocyte migration involved in inflammatory response (GO:0002523)2.55797657
135B cell receptor signaling pathway (GO:0050853)2.54191189
136phagocytosis, engulfment (GO:0006911)2.54056562
137positive regulation of chemokine biosynthetic process (GO:0045080)2.52966683
138cytokine secretion (GO:0050663)2.52207545
139granulocyte migration (GO:0097530)2.51659023
140response to fungus (GO:0009620)2.51332939
141positive regulation of tumor necrosis factor production (GO:0032760)2.49093568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.30348495
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.63209497
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.18940487
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.03390609
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65112157
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.27812215
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87829519
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69694266
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48285713
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45970823
11VDR_21846776_ChIP-Seq_THP-1_Human2.37031693
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36051746
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.29219373
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15872822
15MYC_22102868_ChIP-Seq_BL_Human2.12365080
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11811409
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.10526039
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06614977
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06114129
20MAF_26560356_Chip-Seq_TH1_Human2.04987948
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01653958
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95304263
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92603807
24VDR_24787735_ChIP-Seq_THP-1_Human1.90585060
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81340913
26MYB_26560356_Chip-Seq_TH1_Human1.79850505
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77262827
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76082378
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73556287
30GATA1_22025678_ChIP-Seq_K562_Human1.72378915
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65893639
32UTX_26944678_Chip-Seq_JUKART_Human1.64382072
33SCL_19346495_ChIP-Seq_HPC-7_Human1.62931449
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62467368
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61667600
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59891116
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.59254980
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58729737
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.58556030
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57567787
41GATA3_27048872_Chip-Seq_THYMUS_Human1.51252553
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49365057
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48420325
44TCF7_22412390_ChIP-Seq_EML_Mouse1.48049454
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47611650
46RUNX_20019798_ChIP-Seq_JUKART_Human1.46954153
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.45421939
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44855787
49SPI1_23547873_ChIP-Seq_NB4_Human1.42957004
50* PU_27001747_Chip-Seq_BMDM_Mouse1.40484841
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38499995
52MAF_26560356_Chip-Seq_TH2_Human1.36278956
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32338565
54KDM2B_26808549_Chip-Seq_DND41_Human1.29746371
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26939562
56SPI1_23127762_ChIP-Seq_K562_Human1.26238880
57GATA1_19941826_ChIP-Seq_K562_Human1.25576830
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25231307
59* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25038759
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24999327
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23850001
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19849154
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19513736
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19044422
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18626108
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18465236
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17778223
68VDR_24763502_ChIP-Seq_THP-1_Human1.16661342
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15032238
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10688192
71TAF15_26573619_Chip-Seq_HEK293_Human1.10374327
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09444660
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08692881
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.08434423
75* RUNX1_22412390_ChIP-Seq_EML_Mouse1.07349357
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07025157
77LXR_22292898_ChIP-Seq_THP-1_Human1.07024767
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06711567
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04059240
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03784809
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03784809
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03089004
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01047972
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.01046860
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00610781
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00514254
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00333124
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99008797
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98984542
90EGR1_19032775_ChIP-ChIP_M12_Human0.97549273
91TFEB_21752829_ChIP-Seq_HELA_Human0.97330455
92TP53_16413492_ChIP-PET_HCT116_Human0.96661851
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96028884
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95785558
95GATA2_19941826_ChIP-Seq_K562_Human0.94485672
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94370161
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.91691648
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90779773
99BCL6_27268052_Chip-Seq_Bcells_Human0.90609385
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90395510
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90058311
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90051181
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89244926
104BCOR_27268052_Chip-Seq_Bcells_Human0.88475705
105MYB_26560356_Chip-Seq_TH2_Human0.87770760
106SMRT_27268052_Chip-Seq_Bcells_Human0.87467095
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87325934
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.85734725
109* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85391828
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85203639
111GBX2_23144817_ChIP-Seq_PC3_Human0.84401946
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84330665
113* PU1_27457419_Chip-Seq_LIVER_Mouse0.83844949
114GATA3_26560356_Chip-Seq_TH2_Human0.82395919
115* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81266583
116NCOR1_26117541_ChIP-Seq_K562_Human0.80229734
117* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80064180
118VDR_22108803_ChIP-Seq_LS180_Human0.79916096
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.79251789
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79248130
121TP53_18474530_ChIP-ChIP_U2OS_Human0.78302625
122STAT1_20625510_ChIP-Seq_HELA_Human0.77749263
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77042104
124SPI1_20517297_ChIP-Seq_HL60_Human0.76909791
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76652495
126* CMYC_18555785_Chip-Seq_ESCs_Mouse0.76152679
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.76002925
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.75863120
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75506685
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75287916
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.75278712
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74176076
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74060597
134* P300_18555785_Chip-Seq_ESCs_Mouse0.73672894
135* STAT3_18555785_Chip-Seq_ESCs_Mouse0.73100306
136* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.72982147
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.72803220
138* P53_22387025_ChIP-Seq_ESCs_Mouse0.72577066
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72435443
140* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72232807
141RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72041422
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.71154221
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.70654333
144* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.70608469
145CJUN_26792858_Chip-Seq_BT549_Human0.70510706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.24499051
2MP0003436_decreased_susceptibility_to3.64646999
3MP0003303_peritoneal_inflammation3.50960191
4MP0002148_abnormal_hypersensitivity_rea3.42764862
5MP0002419_abnormal_innate_immunity3.41875853
6MP0005058_abnormal_lysosome_morphology3.37387952
7MP0003724_increased_susceptibility_to3.35684900
8MP0006082_CNS_inflammation3.25860920
9* MP0005000_abnormal_immune_tolerance3.04131118
10MP0009785_altered_susceptibility_to2.96029802
11MP0005025_abnormal_response_to2.74993045
12MP0001790_abnormal_immune_system2.64718613
13MP0005387_immune_system_phenotype2.64718613
14* MP0002452_abnormal_antigen_presenting2.49541101
15MP0003690_abnormal_glial_cell2.46689417
16MP0003172_abnormal_lysosome_physiology2.40999818
17MP0009840_abnormal_foam_cell2.39690532
18* MP0001800_abnormal_humoral_immune2.39012160
19* MP0002723_abnormal_immune_serum2.28666584
20MP0003191_abnormal_cellular_cholesterol2.22933413
21MP0005464_abnormal_platelet_physiology2.21335675
22MP0005671_abnormal_response_to2.18670380
23MP0001533_abnormal_skeleton_physiology2.09079241
24* MP0001819_abnormal_immune_cell1.95281244
25* MP0002420_abnormal_adaptive_immunity1.95110273
26MP0000685_abnormal_immune_system1.88107018
27MP0004510_myositis1.84947487
28MP0009764_decreased_sensitivity_to1.84761203
29MP0001853_heart_inflammation1.82684999
30MP0003075_altered_response_to1.75265029
31* MP0001845_abnormal_inflammatory_respons1.70192592
32MP0008469_abnormal_protein_level1.69285360
33MP0000604_amyloidosis1.68522407
34MP0003763_abnormal_thymus_physiology1.67268691
35* MP0002405_respiratory_system_inflammati1.65447802
36MP0000920_abnormal_myelination1.64458362
37MP0000343_altered_response_to1.64223655
38MP0002998_abnormal_bone_remodeling1.55794185
39MP0005451_abnormal_body_composition1.44149170
40MP0008260_abnormal_autophagy1.38998809
41MP0005360_urolithiasis1.38249549
42MP0005167_abnormal_blood-brain_barrier1.35762426
43MP0001545_abnormal_hematopoietic_system1.34901243
44MP0005397_hematopoietic_system_phenotyp1.34901243
45MP0003195_calcinosis1.34751761
46MP0001851_eye_inflammation1.33026204
47MP0004947_skin_inflammation1.32127346
48MP0010155_abnormal_intestine_physiology1.30705177
49MP0005166_decreased_susceptibility_to1.29902067
50* MP0000716_abnormal_immune_system1.29790977
51MP0002277_abnormal_respiratory_mucosa1.25774828
52MP0003136_yellow_coat_color1.22787218
53MP0005164_abnormal_response_to1.22303013
54MP0002138_abnormal_hepatobiliary_system1.19825352
55MP0003448_altered_tumor_morphology1.19676558
56MP0003183_abnormal_peptide_metabolism1.18606661
57MP0002139_abnormal_hepatobiliary_system1.17288704
58MP0000465_gastrointestinal_hemorrhage1.15680513
59MP0005174_abnormal_tail_pigmentation1.14342495
60MP0009763_increased_sensitivity_to1.12129040
61MP0002933_joint_inflammation1.07099495
62MP0003806_abnormal_nucleotide_metabolis1.06657593
63MP0003828_pulmonary_edema1.06171832
64MP0004381_abnormal_hair_follicle1.06072109
65MP0003300_gastrointestinal_ulcer1.05546277
66MP0009333_abnormal_splenocyte_physiolog1.05413102
67MP0002254_reproductive_system_inflammat1.04923706
68* MP0005310_abnormal_salivary_gland1.04570570
69MP0005085_abnormal_gallbladder_physiolo1.02226682
70* MP0000689_abnormal_spleen_morphology1.00936299
71MP0009278_abnormal_bone_marrow0.99356550
72MP0004883_abnormal_blood_vessel0.96958935
73* MP0002429_abnormal_blood_cell0.96750241
74MP0002398_abnormal_bone_marrow0.96242735
75MP0008875_abnormal_xenobiotic_pharmacok0.91957055
76MP0000703_abnormal_thymus_morphology0.90986812
77* MP0000249_abnormal_blood_vessel0.90972097
78MP0002132_abnormal_respiratory_system0.89595975
79MP0005390_skeleton_phenotype0.88956213
80MP0002166_altered_tumor_susceptibility0.88807268
81MP0003866_abnormal_defecation0.87884781
82MP0002006_tumorigenesis0.86707734
83MP0000858_altered_metastatic_potential0.85462620
84MP0004019_abnormal_vitamin_homeostasis0.84784487
85MP0000015_abnormal_ear_pigmentation0.84469842
86MP0005409_darkened_coat_color0.81680333
87* MP0000609_abnormal_liver_physiology0.81450181
88MP0004782_abnormal_surfactant_physiolog0.79973089
89* MP0002722_abnormal_immune_system0.79790402
90MP0005083_abnormal_biliary_tract0.79454172
91MP0002332_abnormal_exercise_endurance0.78465152
92MP0010329_abnormal_lipoprotein_level0.77964886
93MP0008874_decreased_physiological_sensi0.77662536
94MP0001727_abnormal_embryo_implantation0.76953496
95MP0003453_abnormal_keratinocyte_physiol0.76912242
96MP0002102_abnormal_ear_morphology0.76035427
97MP0008004_abnormal_stomach_pH0.76018619
98MP0003252_abnormal_bile_duct0.75970483
99MP0003091_abnormal_cell_migration0.75965450
100MP0005365_abnormal_bile_salt0.73570984
101MP0000569_abnormal_digit_pigmentation0.73171766
102MP0005584_abnormal_enzyme/coenzyme_acti0.71348950
103MP0002118_abnormal_lipid_homeostasis0.69623478
104MP0004808_abnormal_hematopoietic_stem0.67883276
105MP0003186_abnormal_redox_activity0.67809758
106MP0000371_diluted_coat_color0.66055235
107MP0003795_abnormal_bone_structure0.65870495
108MP0001873_stomach_inflammation0.65271555
109MP0005535_abnormal_body_temperature0.64238522
110* MP0002136_abnormal_kidney_physiology0.64029778
111MP0009765_abnormal_xenobiotic_induced0.63834541
112MP0001986_abnormal_taste_sensitivity0.62224067
113MP0004742_abnormal_vestibular_system0.61409734
114MP0002396_abnormal_hematopoietic_system0.61394227
115MP0003045_fibrosis0.61255947
116MP0003329_amyloid_beta_deposits0.60930792
117MP0005332_abnormal_amino_acid0.60244245
118MP0003221_abnormal_cardiomyocyte_apopto0.59976953
119MP0009115_abnormal_fat_cell0.59526782
120MP0006054_spinal_hemorrhage0.59147773
121MP0001663_abnormal_digestive_system0.58974415
122MP0000767_abnormal_smooth_muscle0.57820806
123MP0003656_abnormal_erythrocyte_physiolo0.57234671

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.05932711
2Systemic lupus erythematosus (HP:0002725)6.37365829
3Recurrent bacterial skin infections (HP:0005406)6.30438499
4Eczematoid dermatitis (HP:0000976)6.23410782
5Recurrent gram-negative bacterial infections (HP:0005420)5.98590482
6Glomerulonephritis (HP:0000099)5.22910387
7Vacuolated lymphocytes (HP:0001922)4.54071953
8Abnormality of macrophages (HP:0004311)4.39226697
9Chronic obstructive pulmonary disease (HP:0006510)4.14761108
10Obstructive lung disease (HP:0006536)4.14761108
11Recurrent skin infections (HP:0001581)4.10622751
12Complement deficiency (HP:0004431)4.03412024
13Mediastinal lymphadenopathy (HP:0100721)3.99637415
14Axonal loss (HP:0003447)3.91181830
15Abnormality of complement system (HP:0005339)3.88033810
16Joint hemorrhage (HP:0005261)3.82369535
17Gingivitis (HP:0000230)3.78344779
18Stomatitis (HP:0010280)3.72971401
19Increased cerebral lipofuscin (HP:0011813)3.66830543
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.49544464
21Thick nail (HP:0001805)3.39060234
22Nephritis (HP:0000123)3.38051204
23Prolonged partial thromboplastin time (HP:0003645)3.27109347
24Gastrointestinal infarctions (HP:0005244)3.22427806
25Dysostosis multiplex (HP:0000943)3.15539045
26Spontaneous hematomas (HP:0007420)3.15321949
27Myositis (HP:0100614)3.13488944
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.10484312
29Abnormality of glycolipid metabolism (HP:0010969)3.10484312
30Abnormality of liposaccharide metabolism (HP:0010968)3.10484312
31Recurrent fungal infections (HP:0002841)3.10275950
32Orchitis (HP:0100796)3.08432653
33Retrobulbar optic neuritis (HP:0100654)3.05152346
34Optic neuritis (HP:0100653)3.05152346
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.04646829
36Meningitis (HP:0001287)3.00005939
37Elevated erythrocyte sedimentation rate (HP:0003565)2.92169476
38Disinhibition (HP:0000734)2.91688008
39Cellulitis (HP:0100658)2.90308314
40T lymphocytopenia (HP:0005403)2.87032129
41Myocardial infarction (HP:0001658)2.85214946
42Pustule (HP:0200039)2.80034155
43Vasculitis (HP:0002633)2.79889031
44Recurrent pneumonia (HP:0006532)2.73121323
45Abnormality of T cell number (HP:0011839)2.70590675
46Colitis (HP:0002583)2.70004606
47Prostate neoplasm (HP:0100787)2.61867462
48Recurrent viral infections (HP:0004429)2.61625290
49Increased IgE level (HP:0003212)2.61369156
50Recurrent cutaneous fungal infections (HP:0011370)2.56553980
51Chronic mucocutaneous candidiasis (HP:0002728)2.56553980
52Osteomyelitis (HP:0002754)2.53251692
53Hepatosplenomegaly (HP:0001433)2.51228732
54Chest pain (HP:0100749)2.48981572
55Inflammation of the large intestine (HP:0002037)2.47911846
56Urticaria (HP:0001025)2.46831768
57Neurofibrillary tangles (HP:0002185)2.46708860
58Arterial thrombosis (HP:0004420)2.44484732
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44457048
60Amyloidosis (HP:0011034)2.43608193
61Recurrent bronchitis (HP:0002837)2.43459298
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42753667
63Lymphopenia (HP:0001888)2.42418919
64Recurrent sinusitis (HP:0011108)2.42002417
65Mutism (HP:0002300)2.39496145
66Gingival bleeding (HP:0000225)2.37964079
67Mucopolysacchariduria (HP:0008155)2.36829941
68Urinary glycosaminoglycan excretion (HP:0003541)2.36829941
69Gangrene (HP:0100758)2.35335877
70Agammaglobulinemia (HP:0004432)2.34568727
71Restrictive lung disease (HP:0002091)2.33654302
72Peripheral demyelination (HP:0011096)2.32445695
73Abnormality of the pleura (HP:0002103)2.31907200
74Pulmonary infiltrates (HP:0002113)2.30836228
75Anorexia (HP:0002039)2.28449277
76Abnormality of polysaccharide metabolism (HP:0011012)2.28318196
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28318196
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28318196
79Purpura (HP:0000979)2.28187353
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.25933346
81Increased IgM level (HP:0003496)2.25495009
82Recurrent lower respiratory tract infections (HP:0002783)2.22458224
83Interstitial pulmonary disease (HP:0006530)2.22237685
84Abnormality of T cells (HP:0002843)2.21681538
85Periodontitis (HP:0000704)2.20446818
86Hematochezia (HP:0002573)2.18433876
87Panhypogammaglobulinemia (HP:0003139)2.18415249
88Prolonged bleeding time (HP:0003010)2.17361200
89Increased serum ferritin (HP:0003281)2.17337409
90Pulmonary embolism (HP:0002204)2.16676949
91Bone pain (HP:0002653)2.14951891
92IgM deficiency (HP:0002850)2.14548839
93Polyneuropathy (HP:0001271)2.14497042
94Gastrointestinal inflammation (HP:0004386)2.14125302
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13817990
96Basal ganglia calcification (HP:0002135)2.13723374
97Autoimmune thrombocytopenia (HP:0001973)2.13355236
98Chronic otitis media (HP:0000389)2.11318914
99Prolonged neonatal jaundice (HP:0006579)2.09223147
100Deep venous thrombosis (HP:0002625)2.08454009
101Abnormality of the peritoneum (HP:0002585)2.08273359
102Loss of speech (HP:0002371)2.07369352
103Agnosia (HP:0010524)2.07059640
104Epistaxis (HP:0000421)2.04491999
105Keratoconjunctivitis sicca (HP:0001097)2.03585238
106Gastrointestinal stroma tumor (HP:0100723)2.01844434
107Premature loss of primary teeth (HP:0006323)1.98084130
108Leukocytosis (HP:0001974)1.96897696
109Upper motor neuron abnormality (HP:0002127)1.96251145
110Hemoptysis (HP:0002105)1.95077346
111Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93876904
112Sepsis (HP:0100806)1.92999808
113Thoracic kyphosis (HP:0002942)1.92718149
114Emphysema (HP:0002097)1.92250955
115Abnormality of the prostate (HP:0008775)1.91943515
116Hypergammaglobulinemia (HP:0010702)1.91808824
117Pathologic fracture (HP:0002756)1.91714134
118Xanthomatosis (HP:0000991)1.91502097
119Glomerulopathy (HP:0100820)1.91346265
120White forelock (HP:0002211)1.90280102
121Abnormality of the lumbar spine (HP:0100712)1.87572638
122Parakeratosis (HP:0001036)1.87389155
123Encephalitis (HP:0002383)1.86249669
124Keratoconjunctivitis (HP:0001096)1.86212460
125Petechiae (HP:0000967)1.86209602
126Menorrhagia (HP:0000132)1.86062869
127Chronic diarrhea (HP:0002028)1.85897882
128Patchy hypopigmentation of hair (HP:0011365)1.79527061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.73512056
2* BLK4.14834848
3IRAK43.55721684
4MAP3K143.53176240
5IRAK33.20225135
6MAP4K12.82663460
7PBK2.71443942
8TYK22.46325227
9PRPF4B2.31710540
10TGFBR22.30696952
11EPHB12.23929677
12MAP3K132.21748091
13TAOK32.20166918
14TBK12.12037419
15TXK2.08443798
16FES2.07239049
17GRK72.06491668
18FGR2.05013975
19CSK1.95291516
20CSF1R1.81974222
21KIT1.74560640
22JAK11.71650122
23IKBKB1.69869798
24ERN11.61848412
25CLK11.59391217
26IKBKE1.58598420
27IRAK11.50587631
28MAP3K31.45415767
29* LYN1.39546228
30TAOK11.37377524
31SYK1.37180098
32TEC1.36044340
33BTK1.34337110
34GRK11.33219876
35PKN11.32555004
36HCK1.31708355
37MAP3K111.30533452
38INSRR1.26446768
39JAK31.23955942
40TAOK21.23682522
41STK101.22699678
42LCK1.18806254
43MAP3K11.17986904
44IRAK21.16456726
45CAMK1D1.15838800
46SIK21.15524735
47NEK91.11045252
48BMPR21.10047851
49ADRBK21.09627864
50MKNK21.06983726
51CDC42BPA1.06189738
52YES11.05854091
53JAK21.02192910
54PIK3CG1.02158708
55MST1R0.98290514
56CAMKK20.94701644
57NME20.94637301
58PRKCQ0.91252703
59CAMK1G0.90928274
60SIK30.90496566
61EIF2AK20.87644991
62TNIK0.87340744
63MST40.84981388
64ZAP700.82458242
65KSR20.81963538
66MATK0.81923139
67ITK0.81836748
68ABL20.77620835
69PRKCD0.74255847
70STK40.73704473
71CASK0.71703332
72PDPK10.70388964
73MAP3K50.67481220
74TRIB30.67249839
75MARK30.66916502
76MAPK150.66599979
77ABL10.65552524
78NEK60.65476369
79KDR0.64009290
80FGFR30.63235853
81MARK20.63076461
82ACVR1B0.62405537
83* FYN0.59497338
84PDK10.58905501
85PRKAA20.58431650
86MAPK70.58357382
87EPHA30.58232379
88NUAK10.57940390
89CHUK0.57264686
90PIK3CA0.57128895
91HIPK20.53699036
92EGFR0.53269608
93BMX0.52094073
94GRK60.51981468
95MAP2K30.51854490
96FGFR40.51590863
97DDR20.50455682
98NLK0.50327772
99SGK30.49211423
100STK390.48996350
101PIM10.47145331
102RPS6KL10.46841543
103RPS6KC10.46841543
104MAPK120.45504379
105PIM20.44680921
106TRPM70.43328004
107OXSR10.42907303
108MAP3K100.41371951
109SGK20.41210031
110MAP3K60.40813200
111TESK20.40635929
112RIPK10.40391662
113IGF1R0.40362281
114CDK40.39461671
115RPS6KA60.38850339
116MAPK40.38641321
117MAP2K60.38397911
118TNK20.38350723
119MOS0.38342724
120PRKD20.38145112
121MAPKAPK20.37670936
122BMPR1B0.37275650
123LRRK20.36812680
124CAMKK10.36716522
125INSR0.35455410
126DMPK0.35094931
127CDK60.33560590
128GSK3A0.33461880
129MAP3K20.32938967
130MAPK110.32589852
131PRKD10.32509390
132DAPK20.30170471
133MAP2K20.30056505
134ERBB40.29607709
135CAMK40.28815645
136MAP3K80.28195585
137SRC0.26205145
138PRKCE0.25879994
139PTK60.24543952

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051504.84947861
2Leishmaniasis_Homo sapiens_hsa051402.87236759
3Complement and coagulation cascades_Homo sapiens_hsa046102.84869528
4Other glycan degradation_Homo sapiens_hsa005112.48453472
5Pertussis_Homo sapiens_hsa051332.35296769
6Lysosome_Homo sapiens_hsa041422.33723483
7Graft-versus-host disease_Homo sapiens_hsa053322.31246414
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.22312440
9* Osteoclast differentiation_Homo sapiens_hsa043802.19351911
10Malaria_Homo sapiens_hsa051442.15787279
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12993899
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.05017737
13Rheumatoid arthritis_Homo sapiens_hsa053232.00357445
14* Tuberculosis_Homo sapiens_hsa051521.95483144
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84825825
16Asthma_Homo sapiens_hsa053101.82416848
17Viral myocarditis_Homo sapiens_hsa054161.75533207
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72370473
19Legionellosis_Homo sapiens_hsa051341.70684478
20* Phagosome_Homo sapiens_hsa041451.63382729
21Hematopoietic cell lineage_Homo sapiens_hsa046401.61532392
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51185523
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50255004
24* B cell receptor signaling pathway_Homo sapiens_hsa046621.49587209
25Salmonella infection_Homo sapiens_hsa051321.47371872
26Allograft rejection_Homo sapiens_hsa053301.42454662
27Histidine metabolism_Homo sapiens_hsa003401.40634738
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38966059
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38166042
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.36901660
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.34169278
32African trypanosomiasis_Homo sapiens_hsa051431.31143875
33Chemokine signaling pathway_Homo sapiens_hsa040621.29749652
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25357421
35Nitrogen metabolism_Homo sapiens_hsa009101.24305261
36Prion diseases_Homo sapiens_hsa050201.22488640
37Caffeine metabolism_Homo sapiens_hsa002321.21395244
38* Measles_Homo sapiens_hsa051621.16999031
39Acute myeloid leukemia_Homo sapiens_hsa052211.11268023
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10568843
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06317895
42Steroid biosynthesis_Homo sapiens_hsa001001.05418399
43TNF signaling pathway_Homo sapiens_hsa046681.03675187
44Primary immunodeficiency_Homo sapiens_hsa053401.01889767
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01479075
46Sphingolipid metabolism_Homo sapiens_hsa006000.96868808
47* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95103364
48Toxoplasmosis_Homo sapiens_hsa051450.93256596
49Influenza A_Homo sapiens_hsa051640.92182968
50Arginine biosynthesis_Homo sapiens_hsa002200.91065324
51Type I diabetes mellitus_Homo sapiens_hsa049400.90785130
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90511289
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.89998822
54ABC transporters_Homo sapiens_hsa020100.89375679
55Autoimmune thyroid disease_Homo sapiens_hsa053200.84681790
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82770151
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.79289128
58Retinol metabolism_Homo sapiens_hsa008300.77401142
59Ether lipid metabolism_Homo sapiens_hsa005650.76950018
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76204560
61Amoebiasis_Homo sapiens_hsa051460.73412063
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72685258
63Antigen processing and presentation_Homo sapiens_hsa046120.72405320
64Peroxisome_Homo sapiens_hsa041460.72112799
65Epstein-Barr virus infection_Homo sapiens_hsa051690.71942864
66Arachidonic acid metabolism_Homo sapiens_hsa005900.71689537
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.69154444
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68851415
69Non-small cell lung cancer_Homo sapiens_hsa052230.64975973
70Prolactin signaling pathway_Homo sapiens_hsa049170.63928107
71PPAR signaling pathway_Homo sapiens_hsa033200.63926566
72beta-Alanine metabolism_Homo sapiens_hsa004100.63666884
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62605049
74Systemic lupus erythematosus_Homo sapiens_hsa053220.61868327
75Fatty acid elongation_Homo sapiens_hsa000620.61079455
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60872262
77VEGF signaling pathway_Homo sapiens_hsa043700.60231929
78Chemical carcinogenesis_Homo sapiens_hsa052040.59861292
79Apoptosis_Homo sapiens_hsa042100.59245833
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59101053
81Tryptophan metabolism_Homo sapiens_hsa003800.58481121
82Herpes simplex infection_Homo sapiens_hsa051680.58117931
83Platelet activation_Homo sapiens_hsa046110.57533455
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.56097838
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54484832
86Pancreatic cancer_Homo sapiens_hsa052120.53167559
87Shigellosis_Homo sapiens_hsa051310.52750998
88Vitamin digestion and absorption_Homo sapiens_hsa049770.52038651
89Chronic myeloid leukemia_Homo sapiens_hsa052200.49166370
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48950084
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48869931
92Hepatitis C_Homo sapiens_hsa051600.48581762
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47926453
94Renal cell carcinoma_Homo sapiens_hsa052110.47575508
95HTLV-I infection_Homo sapiens_hsa051660.47353335
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47339621
97Mineral absorption_Homo sapiens_hsa049780.45585676
98HIF-1 signaling pathway_Homo sapiens_hsa040660.44047538
99Viral carcinogenesis_Homo sapiens_hsa052030.43268241
100FoxO signaling pathway_Homo sapiens_hsa040680.42870127
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42013947
102Starch and sucrose metabolism_Homo sapiens_hsa005000.41886784
103T cell receptor signaling pathway_Homo sapiens_hsa046600.41608338
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.40838381
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38959038
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38766579
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.38480521
108Notch signaling pathway_Homo sapiens_hsa043300.37358690
109GnRH signaling pathway_Homo sapiens_hsa049120.36730056
110Endocytosis_Homo sapiens_hsa041440.36552360
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35780457
112Collecting duct acid secretion_Homo sapiens_hsa049660.34939134
113Dorso-ventral axis formation_Homo sapiens_hsa043200.34535996
114Arginine and proline metabolism_Homo sapiens_hsa003300.33440382
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33108286
116Insulin resistance_Homo sapiens_hsa049310.32779272
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.32778356
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32449868
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31375959
120Hepatitis B_Homo sapiens_hsa051610.29809278
121Bladder cancer_Homo sapiens_hsa052190.29454338
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28376111
123mTOR signaling pathway_Homo sapiens_hsa041500.28019777
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26115363
125MAPK signaling pathway_Homo sapiens_hsa040100.25100408
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24388585
127Renin-angiotensin system_Homo sapiens_hsa046140.23867415
128Type II diabetes mellitus_Homo sapiens_hsa049300.22948520
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21925352
130Choline metabolism in cancer_Homo sapiens_hsa052310.21233786
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21158183
132Prostate cancer_Homo sapiens_hsa052150.16846613
133Estrogen signaling pathway_Homo sapiens_hsa049150.14622667

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