FCGR3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.36107096
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.33669365
3negative regulation of cell killing (GO:0031342)6.33669365
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.21733379
5antigen processing and presentation of endogenous antigen (GO:0019883)5.93055899
6positive regulation by symbiont of host defense response (GO:0052509)5.77846316
7modulation by symbiont of host defense response (GO:0052031)5.77846316
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.77846316
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.77846316
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.77846316
11modulation by symbiont of host immune response (GO:0052553)5.77846316
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.73859582
13positive regulation of gamma-delta T cell activation (GO:0046645)5.69838729
14neutrophil activation involved in immune response (GO:0002283)5.43650852
15macrophage activation involved in immune response (GO:0002281)5.34739704
16detection of other organism (GO:0098543)4.96982333
17negative regulation of interleukin-12 production (GO:0032695)4.71233582
18detection of bacterium (GO:0016045)4.69434827
19response to peptidoglycan (GO:0032494)4.65263095
20detection of molecule of bacterial origin (GO:0032490)4.64785997
21microglial cell activation (GO:0001774)4.51022427
22regulation of B cell receptor signaling pathway (GO:0050855)4.50371534
23detection of external biotic stimulus (GO:0098581)4.50049989
24immunoglobulin mediated immune response (GO:0016064)4.44404897
25cellular extravasation (GO:0045123)4.40528426
26neutrophil activation (GO:0042119)4.13129961
27regulation of gamma-delta T cell activation (GO:0046643)4.10820103
28regulation of interferon-beta biosynthetic process (GO:0045357)4.07312777
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.06817240
30leukocyte aggregation (GO:0070486)4.02268086
31respiratory burst (GO:0045730)4.01086078
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.98291885
33macrophage activation (GO:0042116)3.96020888
34detection of biotic stimulus (GO:0009595)3.94456125
35response to host immune response (GO:0052572)3.88964430
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88964430
37granulocyte activation (GO:0036230)3.88914142
38myeloid cell activation involved in immune response (GO:0002275)3.87631497
39response to interleukin-15 (GO:0070672)3.77790280
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73502767
41regulation of mast cell degranulation (GO:0043304)3.72200819
42type I interferon signaling pathway (GO:0060337)3.70675538
43cellular response to type I interferon (GO:0071357)3.70675538
44positive regulation of mast cell activation (GO:0033005)3.69654817
45response to type I interferon (GO:0034340)3.67198725
46negative regulation of leukocyte mediated immunity (GO:0002704)3.65665318
47leukocyte migration involved in inflammatory response (GO:0002523)3.64080405
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62520643
49antigen processing and presentation via MHC class Ib (GO:0002475)3.59655292
50cellular response to interleukin-15 (GO:0071350)3.58920835
51regulation of T cell tolerance induction (GO:0002664)3.57203826
52response to host defenses (GO:0052200)3.53934165
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.53934165
54response to host (GO:0075136)3.53934165
55production of molecular mediator involved in inflammatory response (GO:0002532)3.50829297
56regulation of gamma-delta T cell differentiation (GO:0045586)3.50204203
57interferon-gamma-mediated signaling pathway (GO:0060333)3.47243130
58regulation of tolerance induction (GO:0002643)3.45309753
59B cell mediated immunity (GO:0019724)3.44624929
60regulation of mast cell activation involved in immune response (GO:0033006)3.42483944
61negative regulation of T cell mediated immunity (GO:0002710)3.37781853
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.35563965
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.30019862
64positive regulation of mast cell degranulation (GO:0043306)3.30019862
65regulation of leukocyte degranulation (GO:0043300)3.29123085
66regulation of mast cell activation (GO:0033003)3.26942069
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.23780955
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18743173
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15943405
70regulation of natural killer cell mediated immunity (GO:0002715)3.15943405
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15603973
72positive regulation of cellular amide metabolic process (GO:0034250)3.15088271
73T cell migration (GO:0072678)3.13804158
74neutrophil mediated immunity (GO:0002446)3.13259557
75regulation of T cell mediated cytotoxicity (GO:0001914)3.10984603
76regulation of antigen processing and presentation (GO:0002577)3.10556017
77B cell receptor signaling pathway (GO:0050853)3.05211242
78regulation of T-helper 2 cell differentiation (GO:0045628)3.05072676
79positive regulation of antigen processing and presentation (GO:0002579)3.03282771
80defense response to protozoan (GO:0042832)3.02938386
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02604927
82positive regulation of B cell differentiation (GO:0045579)3.02423689
83regulation of B cell differentiation (GO:0045577)3.02108105
84positive thymic T cell selection (GO:0045059)3.01094944
85negative regulation of innate immune response (GO:0045824)3.00335765
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99787309
87myeloid leukocyte mediated immunity (GO:0002444)2.98838030
88activated T cell proliferation (GO:0050798)2.97664064
89dendritic cell chemotaxis (GO:0002407)2.96269995
90leukocyte degranulation (GO:0043299)2.95441537
91myeloid leukocyte activation (GO:0002274)2.95032959
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94727571
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94369730
94negative regulation of cytokine production involved in immune response (GO:0002719)2.92964168
95regulation of regulatory T cell differentiation (GO:0045589)2.91915100
96response to muramyl dipeptide (GO:0032495)2.88844403
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88102109
98dendritic cell migration (GO:0036336)2.88023562
99negative regulation of erythrocyte differentiation (GO:0045647)2.87004071
100positive regulation of interferon-alpha production (GO:0032727)2.86809408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.05723984
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.05217679
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.69372053
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75768319
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60236866
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.54109014
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50245347
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40808743
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10185512
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92589162
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87911630
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71713510
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67563449
14SPI1_23127762_ChIP-Seq_K562_Human2.64468328
15RUNX_20019798_ChIP-Seq_JUKART_Human2.63281076
16SPI1_23547873_ChIP-Seq_NB4_Human2.60116716
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.58822414
18VDR_24763502_ChIP-Seq_THP-1_Human2.48340311
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37608444
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36789423
21VDR_21846776_ChIP-Seq_THP-1_Human2.34032279
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26897781
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22274818
24MAF_26560356_Chip-Seq_TH1_Human2.13797248
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.12117607
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11636597
27* MYB_26560356_Chip-Seq_TH2_Human2.11327888
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06473185
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05622981
30SCL_19346495_ChIP-Seq_HPC-7_Human2.03833922
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03112013
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99044211
33VDR_24787735_ChIP-Seq_THP-1_Human1.94298514
34UTX_26944678_Chip-Seq_JUKART_Human1.86408187
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.83822964
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81148692
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79233039
38MYB_26560356_Chip-Seq_TH1_Human1.78380936
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71667626
40TCF7_22412390_ChIP-Seq_EML_Mouse1.63802845
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62481160
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61541902
43GATA3_27048872_Chip-Seq_THYMUS_Human1.60202015
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.54850875
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.53547998
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52661424
47MAF_26560356_Chip-Seq_TH2_Human1.52560747
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52130147
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50870063
50MYC_22102868_ChIP-Seq_BL_Human1.47939306
51KDM2B_26808549_Chip-Seq_DND41_Human1.45902818
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39258566
53PU_27001747_Chip-Seq_BMDM_Mouse1.38145650
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38093142
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37510976
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31758758
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30422218
58GATA3_26560356_Chip-Seq_TH2_Human1.30260994
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30258693
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30118232
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29153346
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29076979
63GATA1_22025678_ChIP-Seq_K562_Human1.25626173
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25506865
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23949586
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23869164
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23423743
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23006259
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21222807
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19147057
71LXR_22292898_ChIP-Seq_THP-1_Human1.18954029
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18635641
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16080393
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.15790826
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14305692
76GATA1_19941826_ChIP-Seq_K562_Human1.14138158
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.10298042
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09657237
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05489728
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05468260
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01527949
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99365537
83BCL6_27268052_Chip-Seq_Bcells_Human0.98948215
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.97040321
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94477898
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93704286
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93609643
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92532532
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89300998
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88915308
91GATA2_19941826_ChIP-Seq_K562_Human0.88644037
92BCOR_27268052_Chip-Seq_Bcells_Human0.86818251
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79819575
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77334010
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76845190
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76741881
97SPI1_20517297_ChIP-Seq_HL60_Human0.76199112
98EGR1_19032775_ChIP-ChIP_M12_Human0.74588474
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74131451
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73450207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.88290418
2MP0001835_abnormal_antigen_presentation4.08630958
3MP0003436_decreased_susceptibility_to4.04957598
4MP0003303_peritoneal_inflammation3.53359159
5MP0005671_abnormal_response_to3.45726527
6MP0006082_CNS_inflammation3.40957134
7MP0002419_abnormal_innate_immunity3.24279835
8MP0009785_altered_susceptibility_to3.12407642
9MP0005025_abnormal_response_to3.00690939
10MP0001790_abnormal_immune_system2.90477371
11MP0005387_immune_system_phenotype2.90477371
12MP0005000_abnormal_immune_tolerance2.89489078
13MP0000685_abnormal_immune_system2.84991954
14MP0001800_abnormal_humoral_immune2.83480601
15MP0002723_abnormal_immune_serum2.60391416
16MP0002148_abnormal_hypersensitivity_rea2.56981311
17MP0002452_abnormal_antigen_presenting2.54766484
18MP0003191_abnormal_cellular_cholesterol2.51081253
19MP0002420_abnormal_adaptive_immunity2.46698641
20MP0001819_abnormal_immune_cell2.44444753
21MP0003300_gastrointestinal_ulcer2.38363918
22MP0001533_abnormal_skeleton_physiology2.18796078
23MP0005464_abnormal_platelet_physiology2.07999529
24MP0002405_respiratory_system_inflammati1.96769768
25MP0008260_abnormal_autophagy1.93059131
26MP0003172_abnormal_lysosome_physiology1.91663294
27MP0001845_abnormal_inflammatory_respons1.84324554
28MP0003763_abnormal_thymus_physiology1.82395017
29MP0000716_abnormal_immune_system1.78966858
30MP0010155_abnormal_intestine_physiology1.75577765
31MP0005058_abnormal_lysosome_morphology1.72066298
32MP0003690_abnormal_glial_cell1.71604298
33MP0003828_pulmonary_edema1.71516179
34MP0002398_abnormal_bone_marrow1.69727315
35MP0009764_decreased_sensitivity_to1.66506889
36MP0009333_abnormal_splenocyte_physiolog1.63913377
37MP0008469_abnormal_protein_level1.58541348
38MP0004883_abnormal_blood_vessel1.57677016
39MP0004947_skin_inflammation1.57516086
40MP0003075_altered_response_to1.54545148
41MP0000858_altered_metastatic_potential1.51425273
42MP0009278_abnormal_bone_marrow1.50497670
43MP0002277_abnormal_respiratory_mucosa1.49152942
44MP0003183_abnormal_peptide_metabolism1.48605281
45MP0002998_abnormal_bone_remodeling1.46968581
46MP0000689_abnormal_spleen_morphology1.45607750
47MP0002132_abnormal_respiratory_system1.42355496
48MP0003866_abnormal_defecation1.40847502
49MP0000343_altered_response_to1.40811267
50MP0005310_abnormal_salivary_gland1.40619426
51MP0000604_amyloidosis1.40451383
52MP0002722_abnormal_immune_system1.40363225
53MP0002429_abnormal_blood_cell1.37495952
54MP0000465_gastrointestinal_hemorrhage1.36263852
55MP0004510_myositis1.30581920
56MP0005451_abnormal_body_composition1.28675472
57MP0005164_abnormal_response_to1.25776722
58MP0009840_abnormal_foam_cell1.24761304
59MP0003448_altered_tumor_morphology1.22606506
60MP0001851_eye_inflammation1.20696554
61MP0005166_decreased_susceptibility_to1.20478455
62MP0000703_abnormal_thymus_morphology1.15496026
63MP0005397_hematopoietic_system_phenotyp1.13520660
64MP0001545_abnormal_hematopoietic_system1.13520660
65MP0001853_heart_inflammation1.06326691
66MP0004381_abnormal_hair_follicle1.02892237
67MP0009763_increased_sensitivity_to0.97944397
68MP0002396_abnormal_hematopoietic_system0.94494033
69MP0008004_abnormal_stomach_pH0.88392471
70MP0002166_altered_tumor_susceptibility0.87192080
71MP0002933_joint_inflammation0.86311903
72MP0005390_skeleton_phenotype0.85097371
73MP0000920_abnormal_myelination0.84253554
74MP0001663_abnormal_digestive_system0.83573877
75MP0003806_abnormal_nucleotide_metabolis0.79357619
76MP0000249_abnormal_blood_vessel0.76805925
77MP0005167_abnormal_blood-brain_barrier0.76198115
78MP0003045_fibrosis0.74858160
79MP0003795_abnormal_bone_structure0.73058075
80MP0003329_amyloid_beta_deposits0.71686269
81MP0000569_abnormal_digit_pigmentation0.67383047
82MP0003656_abnormal_erythrocyte_physiolo0.66339333
83MP0001873_stomach_inflammation0.66154592
84MP0001986_abnormal_taste_sensitivity0.65444692
85MP0008874_decreased_physiological_sensi0.63762654
86MP0009765_abnormal_xenobiotic_induced0.62586192
87MP0006054_spinal_hemorrhage0.60887254
88MP0002138_abnormal_hepatobiliary_system0.59840491
89MP0000490_abnormal_crypts_of0.58425134
90MP0005388_respiratory_system_phenotype0.56963656
91MP0002133_abnormal_respiratory_system0.56963656
92MP0003091_abnormal_cell_migration0.56501422
93MP0001958_emphysema0.56040916
94MP0000015_abnormal_ear_pigmentation0.52169155
95MP0004808_abnormal_hematopoietic_stem0.51781714
96MP0005319_abnormal_enzyme/_coenzyme0.51326163
97MP0002332_abnormal_exercise_endurance0.49858897
98MP0002006_tumorigenesis0.48914377
99MP0005075_abnormal_melanosome_morpholog0.46914064
100MP0005381_digestive/alimentary_phenotyp0.46042621

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.72566418
2Recurrent abscess formation (HP:0002722)6.40507667
3Recurrent bacterial skin infections (HP:0005406)6.26307585
4Abnormality of macrophages (HP:0004311)5.79494089
5Recurrent gram-negative bacterial infections (HP:0005420)5.46350705
6Myositis (HP:0100614)5.33771966
7Orchitis (HP:0100796)5.14636050
8Optic neuritis (HP:0100653)4.88794481
9Retrobulbar optic neuritis (HP:0100654)4.88794481
10Stomatitis (HP:0010280)4.25765216
11Elevated erythrocyte sedimentation rate (HP:0003565)4.20152930
12Mediastinal lymphadenopathy (HP:0100721)4.16121887
13Recurrent skin infections (HP:0001581)4.03748692
14Recurrent fungal infections (HP:0002841)3.97363519
15Obstructive lung disease (HP:0006536)3.96573838
16Chronic obstructive pulmonary disease (HP:0006510)3.96573838
17Gastrointestinal infarctions (HP:0005244)3.88981514
18Meningitis (HP:0001287)3.81509805
19Gingivitis (HP:0000230)3.80956861
20Spontaneous hematomas (HP:0007420)3.69180597
21Systemic lupus erythematosus (HP:0002725)3.63823250
22Keratoconjunctivitis sicca (HP:0001097)3.50733837
23Encephalitis (HP:0002383)3.48464165
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.47308943
25Chronic mucocutaneous candidiasis (HP:0002728)3.46428912
26Recurrent cutaneous fungal infections (HP:0011370)3.46428912
27Abnormality of glycolipid metabolism (HP:0010969)3.45272709
28Abnormality of liposaccharide metabolism (HP:0010968)3.45272709
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.45272709
30T lymphocytopenia (HP:0005403)3.39196731
31Abnormality of T cell number (HP:0011839)3.27634900
32Vasculitis (HP:0002633)3.25250493
33Keratoconjunctivitis (HP:0001096)3.21926727
34Urticaria (HP:0001025)3.21632795
35Hemoptysis (HP:0002105)3.07004219
36Pulmonary infiltrates (HP:0002113)3.05494484
37Increased IgE level (HP:0003212)2.95215584
38Cellulitis (HP:0100658)2.94351666
39Chronic otitis media (HP:0000389)2.89559923
40Chest pain (HP:0100749)2.89313423
41Leukocytosis (HP:0001974)2.85413158
42Increased cerebral lipofuscin (HP:0011813)2.85342918
43Prolonged bleeding time (HP:0003010)2.81986415
44Pustule (HP:0200039)2.79594033
45Gingival bleeding (HP:0000225)2.74378815
46Hypochromic microcytic anemia (HP:0004840)2.74351901
47Recurrent viral infections (HP:0004429)2.68846659
48Increased IgM level (HP:0003496)2.66673269
49Pulmonary embolism (HP:0002204)2.64506764
50Arterial thrombosis (HP:0004420)2.62528398
51Amyloidosis (HP:0011034)2.59443354
52Hypochromic anemia (HP:0001931)2.59113483
53Epistaxis (HP:0000421)2.58506131
54Purpura (HP:0000979)2.55775941
55Episodic fever (HP:0001954)2.53859104
56Anorexia (HP:0002039)2.52476509
57Peritonitis (HP:0002586)2.51405747
58Abnormality of T cells (HP:0002843)2.51020971
59Loss of speech (HP:0002371)2.44200659
60Nasal polyposis (HP:0100582)2.43412969
61Glomerulonephritis (HP:0000099)2.43072431
62Inflammation of the large intestine (HP:0002037)2.42524620
63Osteomyelitis (HP:0002754)2.40200747
64Recurrent bronchitis (HP:0002837)2.37977391
65Disinhibition (HP:0000734)2.37546397
66Abnormality of the nasal mucosa (HP:0000433)2.31199033
67Gastrointestinal inflammation (HP:0004386)2.31169864
68Granulocytopenia (HP:0001913)2.30921660
69Increased serum ferritin (HP:0003281)2.30442834
70Petechiae (HP:0000967)2.29884749
71Hypergammaglobulinemia (HP:0010702)2.29208900
72Premature loss of primary teeth (HP:0006323)2.26565541
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.26531513
74Gangrene (HP:0100758)2.24637268
75Abnormality of iron homeostasis (HP:0011031)2.19221349
76Dysostosis multiplex (HP:0000943)2.17178321
77Abnormality of the pleura (HP:0002103)2.17073384
78Autoimmune thrombocytopenia (HP:0001973)2.16270390
79Panhypogammaglobulinemia (HP:0003139)2.14581114
80Microcytic anemia (HP:0001935)2.13254504
81Eosinophilia (HP:0001880)2.09901877
82Sepsis (HP:0100806)2.09533217
83Glomerulopathy (HP:0100820)2.08203534
84Colitis (HP:0002583)2.05646027
85Abnormality of the endocardium (HP:0004306)2.03971485
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02747997
87Abnormality of the peritoneum (HP:0002585)2.02716546
88Lymphopenia (HP:0001888)2.01128641
89Vertigo (HP:0002321)2.00842098
90Acne (HP:0001061)1.99557816
91Skin ulcer (HP:0200042)1.99233703
92Vacuolated lymphocytes (HP:0001922)1.96001931
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.94242728
94Hepatosplenomegaly (HP:0001433)1.93957370
95Polyneuropathy (HP:0001271)1.93890764
96Interstitial pulmonary disease (HP:0006530)1.90975763
97Malnutrition (HP:0004395)1.88510184
98Joint swelling (HP:0001386)1.86244858
99Recurrent pneumonia (HP:0006532)1.86085893
100Abnormality of T cell physiology (HP:0011840)1.82524864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.63586890
2BLK3.86899289
3MAP4K13.60587782
4IRAK43.09401855
5TYK23.03651338
6CSK2.91986399
7FES2.66854375
8ERN12.62873710
9MAP2K32.60863429
10TXK2.31377208
11MAP3K132.25838926
12ZAP702.23654929
13TNK22.01519557
14FGR1.97756385
15JAK31.94295156
16EPHB11.91505801
17PRPF4B1.87727422
18MAP3K141.77968774
19GRK61.77309414
20SYK1.74123470
21HCK1.71124975
22BTK1.70701767
23MAP3K31.70170536
24TAOK31.69412429
25JAK11.57832901
26TGFBR21.57389245
27IKBKE1.57380889
28TAOK11.52669750
29CSF1R1.50803117
30LYN1.47598108
31MAP3K111.46006483
32JAK21.45232484
33TBK11.42743538
34KSR21.38206214
35KIT1.27962679
36LCK1.24571255
37MAP3K11.21817564
38BMPR21.15583709
39GRK71.11909174
40ITK1.10290984
41MATK1.10264614
42YES11.05746605
43MARK30.96859441
44SIK30.93642330
45STK100.92343413
46PDK10.91382452
47IKBKB0.91046001
48MARK20.84310792
49IRAK10.84231710
50PDPK10.81121951
51TEC0.80433465
52PTK60.77931849
53PRKD20.73560401
54FYN0.72868170
55MOS0.70740715
56TAOK20.70510707
57FGFR40.69934168
58CDC42BPA0.69683122
59IRAK20.69640972
60LRRK20.68364142
61TESK20.67305569
62MAP3K60.65878084
63MAP3K20.65309534
64EPHA30.64151551
65KSR10.63641403
66PIK3CG0.60934464
67FGFR30.60827932
68MAPK120.60486273
69TRIB30.56914223
70MAP3K70.55176957
71PRKCQ0.54253752
72CAMKK20.53846130
73RIPK10.53480605
74SGK30.49927520
75MAPK70.49778870
76SIK20.49660969
77RAF10.49015490
78MAP3K50.48755323
79DYRK1B0.48684284
80MAP2K40.46417566
81MAP2K60.45110800
82PTK2B0.44781969
83STK110.44515806
84HIPK20.44068835
85RET0.43890959
86CDK190.42450299
87PIM10.39974071
88ACVR1B0.39060085
89RPS6KL10.37661618
90RPS6KC10.37661618
91SGK20.36852952
92DAPK20.35694464
93IRAK30.35625107
94NLK0.34353071
95MAPKAPK20.34291591
96CAMKK10.32995062
97STK380.31744482
98PRKCH0.31724656
99RPS6KA60.30446951
100PRKCD0.29889674

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051503.46164512
2* Leishmaniasis_Homo sapiens_hsa051403.00169629
3* Osteoclast differentiation_Homo sapiens_hsa043802.91697871
4Graft-versus-host disease_Homo sapiens_hsa053322.84680299
5Allograft rejection_Homo sapiens_hsa053302.76081022
6Autoimmune thyroid disease_Homo sapiens_hsa053202.58071819
7* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28398912
8* Tuberculosis_Homo sapiens_hsa051522.16535432
9Antigen processing and presentation_Homo sapiens_hsa046122.13581563
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12290207
11Type I diabetes mellitus_Homo sapiens_hsa049402.08797813
12B cell receptor signaling pathway_Homo sapiens_hsa046621.99864701
13Malaria_Homo sapiens_hsa051441.95838219
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95612366
15Primary immunodeficiency_Homo sapiens_hsa053401.87564519
16* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87506444
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80970813
18Viral myocarditis_Homo sapiens_hsa054161.78357958
19* Phagosome_Homo sapiens_hsa041451.69575156
20Chemokine signaling pathway_Homo sapiens_hsa040621.69297297
21Measles_Homo sapiens_hsa051621.65818522
22Hematopoietic cell lineage_Homo sapiens_hsa046401.65735892
23Asthma_Homo sapiens_hsa053101.63044209
24Legionellosis_Homo sapiens_hsa051341.59465240
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56986615
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.56975382
27Toxoplasmosis_Homo sapiens_hsa051451.52980921
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.52815456
29Pertussis_Homo sapiens_hsa051331.52311424
30Rheumatoid arthritis_Homo sapiens_hsa053231.50667508
31Other glycan degradation_Homo sapiens_hsa005111.50584333
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48373207
33Influenza A_Homo sapiens_hsa051641.47169134
34T cell receptor signaling pathway_Homo sapiens_hsa046601.46538408
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46173028
36Lysosome_Homo sapiens_hsa041421.34576578
37Acute myeloid leukemia_Homo sapiens_hsa052211.33272153
38Herpes simplex infection_Homo sapiens_hsa051681.25963671
39TNF signaling pathway_Homo sapiens_hsa046681.21441725
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21310678
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.17731613
42African trypanosomiasis_Homo sapiens_hsa051431.15124251
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.12729398
44Salmonella infection_Homo sapiens_hsa051321.08747943
45Platelet activation_Homo sapiens_hsa046111.04576579
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00560205
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00498225
48Hepatitis C_Homo sapiens_hsa051600.99890386
49Non-small cell lung cancer_Homo sapiens_hsa052230.96729454
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95649364
51Hepatitis B_Homo sapiens_hsa051610.93748964
52Apoptosis_Homo sapiens_hsa042100.89548507
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88588647
54Shigellosis_Homo sapiens_hsa051310.85532206
55Pancreatic cancer_Homo sapiens_hsa052120.81616038
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80694810
57Complement and coagulation cascades_Homo sapiens_hsa046100.77904454
58VEGF signaling pathway_Homo sapiens_hsa043700.77394283
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.75401854
60Endocytosis_Homo sapiens_hsa041440.72405445
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.70191397
62Chronic myeloid leukemia_Homo sapiens_hsa052200.68670621
63Prolactin signaling pathway_Homo sapiens_hsa049170.65729771
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65413996
65Renal cell carcinoma_Homo sapiens_hsa052110.64667637
66Amoebiasis_Homo sapiens_hsa051460.63365542
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.63166555
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62946835
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.61198173
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59075285
71Prion diseases_Homo sapiens_hsa050200.54270233
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52901087
73Epstein-Barr virus infection_Homo sapiens_hsa051690.52296361
74Notch signaling pathway_Homo sapiens_hsa043300.51417404
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.51294188
76FoxO signaling pathway_Homo sapiens_hsa040680.48785071
77GnRH signaling pathway_Homo sapiens_hsa049120.45333725
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44836493
79HTLV-I infection_Homo sapiens_hsa051660.44671132
80Collecting duct acid secretion_Homo sapiens_hsa049660.44564996
81Dorso-ventral axis formation_Homo sapiens_hsa043200.43431650
82HIF-1 signaling pathway_Homo sapiens_hsa040660.41714322
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40955750
84Endometrial cancer_Homo sapiens_hsa052130.40761167
85Choline metabolism in cancer_Homo sapiens_hsa052310.40588373
86Viral carcinogenesis_Homo sapiens_hsa052030.40576789
87Rap1 signaling pathway_Homo sapiens_hsa040150.39529379
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38102074
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36579444
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36290907
91Type II diabetes mellitus_Homo sapiens_hsa049300.35144702
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34827133
93MAPK signaling pathway_Homo sapiens_hsa040100.31359656
94Insulin resistance_Homo sapiens_hsa049310.31232325
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30329969
96Colorectal cancer_Homo sapiens_hsa052100.30300811
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.29968288
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29886718
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29196492
100Inositol phosphate metabolism_Homo sapiens_hsa005620.28638696

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