FCGR3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.30961278
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.87708307
3negative regulation of cell killing (GO:0031342)6.87708307
4positive regulation by symbiont of host defense response (GO:0052509)6.71043215
5modulation by symbiont of host defense response (GO:0052031)6.71043215
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.71043215
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.71043215
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.71043215
9modulation by symbiont of host immune response (GO:0052553)6.71043215
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13790138
11antigen processing and presentation of endogenous antigen (GO:0019883)5.83155678
12positive regulation of gamma-delta T cell activation (GO:0046645)5.71105241
13detection of molecule of bacterial origin (GO:0032490)5.59266287
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.48494307
15macrophage activation involved in immune response (GO:0002281)5.48379057
16detection of other organism (GO:0098543)5.44448420
17neutrophil activation involved in immune response (GO:0002283)5.28810620
18regulation of B cell receptor signaling pathway (GO:0050855)5.14385636
19detection of external biotic stimulus (GO:0098581)5.10148164
20detection of bacterium (GO:0016045)5.03719332
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.96411641
22leukocyte migration involved in inflammatory response (GO:0002523)4.85294589
23response to interleukin-15 (GO:0070672)4.84700726
24regulation of interferon-beta biosynthetic process (GO:0045357)4.83411826
25response to peptidoglycan (GO:0032494)4.70982738
26cellular extravasation (GO:0045123)4.67864646
27microglial cell activation (GO:0001774)4.66196104
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.65946114
29response to host immune response (GO:0052572)4.65946114
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.62115283
31leukocyte aggregation (GO:0070486)4.60093430
32cellular response to interleukin-15 (GO:0071350)4.57191159
33neutrophil activation (GO:0042119)4.52048660
34detection of biotic stimulus (GO:0009595)4.42325034
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37237824
36negative regulation of interleukin-12 production (GO:0032695)4.36723406
37respiratory burst (GO:0045730)4.35629674
38response to host (GO:0075136)4.28177055
39response to host defenses (GO:0052200)4.28177055
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.28177055
41neutrophil mediated immunity (GO:0002446)4.23873924
42macrophage activation (GO:0042116)4.15960541
43regulation of gamma-delta T cell activation (GO:0046643)4.11754080
44granulocyte activation (GO:0036230)4.02301280
45cellular response to type I interferon (GO:0071357)4.00786243
46type I interferon signaling pathway (GO:0060337)4.00786243
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.00440633
48negative regulation of leukocyte mediated immunity (GO:0002704)3.99816874
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.98384253
50response to type I interferon (GO:0034340)3.97215995
51antigen processing and presentation via MHC class Ib (GO:0002475)3.95112387
52myeloid cell activation involved in immune response (GO:0002275)3.83117191
53production of molecular mediator involved in inflammatory response (GO:0002532)3.81020155
54immunoglobulin mediated immune response (GO:0016064)3.77102213
55negative regulation of T cell mediated immunity (GO:0002710)3.71201178
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68307793
57regulation of gamma-delta T cell differentiation (GO:0045586)3.65484026
58myeloid leukocyte mediated immunity (GO:0002444)3.63294359
59regulation of mast cell degranulation (GO:0043304)3.59639193
60response to interferon-alpha (GO:0035455)3.59050580
61dendritic cell migration (GO:0036336)3.48432671
62B cell receptor signaling pathway (GO:0050853)3.47140016
63dendritic cell chemotaxis (GO:0002407)3.43664608
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.38123706
65regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.37934268
66positive regulation of mast cell activation (GO:0033005)3.35355000
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34962371
68regulation of mast cell activation involved in immune response (GO:0033006)3.32207137
69positive regulation of interferon-alpha production (GO:0032727)3.32067291
70regulation of T cell mediated cytotoxicity (GO:0001914)3.30289057
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.26272032
72negative regulation of T-helper cell differentiation (GO:0045623)3.26272032
73leukocyte degranulation (GO:0043299)3.23695195
74negative regulation of phagocytosis (GO:0050765)3.20755493
75regulation of T cell tolerance induction (GO:0002664)3.19224662
76regulation of mast cell activation (GO:0033003)3.19053702
77regulation of B cell differentiation (GO:0045577)3.17094671
78regulation of leukocyte degranulation (GO:0043300)3.16608608
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15211028
80interferon-gamma-mediated signaling pathway (GO:0060333)3.15072514
81regulation of tolerance induction (GO:0002643)3.15048366
82defense response to protozoan (GO:0042832)3.14222673
83regulation of T-helper 2 cell differentiation (GO:0045628)3.12850943
84negative regulation of type 2 immune response (GO:0002829)3.11990989
85germinal center formation (GO:0002467)3.08865949
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05785137
87regulation of interferon-alpha production (GO:0032647)3.05770289
88B cell mediated immunity (GO:0019724)3.03243407
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99424062
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98888855
91positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97816831
92negative regulation of innate immune response (GO:0045824)2.95178199
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94536932
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94407998
95regulation of natural killer cell mediated immunity (GO:0002715)2.94407998
96myeloid leukocyte activation (GO:0002274)2.92985715
97neutrophil chemotaxis (GO:0030593)2.92722376
98regulation of regulatory T cell differentiation (GO:0045589)2.91244199
99response to muramyl dipeptide (GO:0032495)2.90285973
100regulation of regulated secretory pathway (GO:1903305)2.88468145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.88937721
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.03096793
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.56535546
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.92315199
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.86579701
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84616129
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.30328088
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26698357
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.24888783
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06820299
11SPI1_23547873_ChIP-Seq_NB4_Human2.90389535
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87879832
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83369198
14RUNX_20019798_ChIP-Seq_JUKART_Human2.80466505
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74438437
16SPI1_23127762_ChIP-Seq_K562_Human2.71657602
17VDR_24763502_ChIP-Seq_THP-1_Human2.53895027
18VDR_21846776_ChIP-Seq_THP-1_Human2.46798263
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46275343
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42661566
21MAF_26560356_Chip-Seq_TH1_Human2.36090256
22MYB_26560356_Chip-Seq_TH2_Human2.35497251
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.30797230
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22949429
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.21644530
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14278405
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13808119
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12355582
29SCL_19346495_ChIP-Seq_HPC-7_Human2.07027049
30UTX_26944678_Chip-Seq_JUKART_Human2.06873831
31MYB_26560356_Chip-Seq_TH1_Human2.03248769
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96816227
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93986016
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92310499
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.86495560
36TCF7_22412390_ChIP-Seq_EML_Mouse1.85001878
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79451251
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78636051
39MYC_22102868_ChIP-Seq_BL_Human1.78486670
40GATA3_27048872_Chip-Seq_THYMUS_Human1.78457173
41VDR_24787735_ChIP-Seq_THP-1_Human1.77988717
42MAF_26560356_Chip-Seq_TH2_Human1.70031337
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64304411
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62232470
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60504014
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60253388
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58768989
48KDM2B_26808549_Chip-Seq_DND41_Human1.58374811
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.52644657
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44552217
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43341589
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43094324
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42503047
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39741649
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38855997
56* GATA3_26560356_Chip-Seq_TH2_Human1.38593961
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36066330
58PU_27001747_Chip-Seq_BMDM_Mouse1.36032229
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35415627
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34150738
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33719060
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33108143
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26486298
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26269171
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23592049
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22492153
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21373281
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20355842
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19906875
70GATA1_22025678_ChIP-Seq_K562_Human1.19548878
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17311604
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.16646981
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16620757
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16176874
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15211715
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14665761
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14435976
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13096195
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12698595
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.12215279
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08671611
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08199931
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.08043933
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06371474
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03591073
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03018445
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02813562
88GATA1_19941826_ChIP-Seq_K562_Human0.96300080
89BCL6_27268052_Chip-Seq_Bcells_Human0.90711923
90LXR_22292898_ChIP-Seq_THP-1_Human0.90201762
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87477500
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87163190
93GATA2_19941826_ChIP-Seq_K562_Human0.86764269
94BCOR_27268052_Chip-Seq_Bcells_Human0.80110454
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78816570
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77637108
97NCOR1_26117541_ChIP-Seq_K562_Human0.77196454
98SPI1_20517297_ChIP-Seq_HL60_Human0.76357565
99SMRT_27268052_Chip-Seq_Bcells_Human0.73654431
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72864633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.21833165
2MP0003436_decreased_susceptibility_to4.37467074
3MP0001835_abnormal_antigen_presentation3.78519238
4MP0003303_peritoneal_inflammation3.67898826
5MP0002419_abnormal_innate_immunity3.22560388
6MP0009785_altered_susceptibility_to3.02880487
7MP0005025_abnormal_response_to2.95269629
8MP0005671_abnormal_response_to2.93247045
9MP0001800_abnormal_humoral_immune2.90611064
10MP0000685_abnormal_immune_system2.77643243
11MP0005000_abnormal_immune_tolerance2.76941102
12MP0003191_abnormal_cellular_cholesterol2.71321246
13MP0005387_immune_system_phenotype2.66561116
14MP0001790_abnormal_immune_system2.66561116
15MP0002723_abnormal_immune_serum2.60147895
16MP0002420_abnormal_adaptive_immunity2.53295957
17MP0001819_abnormal_immune_cell2.50736073
18MP0006082_CNS_inflammation2.48469470
19MP0002452_abnormal_antigen_presenting2.45178236
20MP0008260_abnormal_autophagy2.35412138
21MP0001533_abnormal_skeleton_physiology2.28533694
22MP0003300_gastrointestinal_ulcer2.25014197
23MP0002132_abnormal_respiratory_system2.23539169
24MP0002277_abnormal_respiratory_mucosa2.14658017
25MP0002148_abnormal_hypersensitivity_rea2.11029070
26MP0002405_respiratory_system_inflammati2.01550351
27MP0003763_abnormal_thymus_physiology1.98535669
28MP0002398_abnormal_bone_marrow1.89655332
29MP0000716_abnormal_immune_system1.87934515
30MP0003828_pulmonary_edema1.87603104
31MP0005464_abnormal_platelet_physiology1.83279999
32MP0002396_abnormal_hematopoietic_system1.80237687
33MP0005451_abnormal_body_composition1.77526505
34MP0003866_abnormal_defecation1.72908535
35MP0001845_abnormal_inflammatory_respons1.72669099
36MP0010155_abnormal_intestine_physiology1.70286138
37MP0000465_gastrointestinal_hemorrhage1.70176495
38MP0004381_abnormal_hair_follicle1.69657268
39MP0004883_abnormal_blood_vessel1.66565377
40MP0009278_abnormal_bone_marrow1.65426359
41MP0003183_abnormal_peptide_metabolism1.62571532
42MP0002722_abnormal_immune_system1.57175050
43MP0009764_decreased_sensitivity_to1.55538801
44MP0003172_abnormal_lysosome_physiology1.54462223
45MP0000689_abnormal_spleen_morphology1.54135663
46MP0004947_skin_inflammation1.50234671
47MP0002429_abnormal_blood_cell1.46182715
48MP0000703_abnormal_thymus_morphology1.44984116
49MP0008469_abnormal_protein_level1.44513073
50MP0000858_altered_metastatic_potential1.44238729
51MP0009333_abnormal_splenocyte_physiolog1.36808661
52MP0005164_abnormal_response_to1.32328822
53MP0003075_altered_response_to1.25385499
54MP0005310_abnormal_salivary_gland1.23500619
55MP0005397_hematopoietic_system_phenotyp1.19457570
56MP0001545_abnormal_hematopoietic_system1.19457570
57MP0001851_eye_inflammation1.19336624
58MP0003690_abnormal_glial_cell1.17658307
59MP0002998_abnormal_bone_remodeling1.06201798
60MP0002166_altered_tumor_susceptibility1.05695737
61MP0005166_decreased_susceptibility_to0.96839207
62MP0004510_myositis0.95260565
63MP0003448_altered_tumor_morphology0.91211958
64MP0000569_abnormal_digit_pigmentation0.91060514
65MP0005390_skeleton_phenotype0.90278951
66MP0003045_fibrosis0.88708392
67MP0005075_abnormal_melanosome_morpholog0.85503536
68MP0009763_increased_sensitivity_to0.83650680
69MP0003221_abnormal_cardiomyocyte_apopto0.82462165
70MP0000343_altered_response_to0.80419462
71MP0001663_abnormal_digestive_system0.75627673
72MP0004130_abnormal_muscle_cell0.75395275
73MP0000015_abnormal_ear_pigmentation0.75196198
74MP0008004_abnormal_stomach_pH0.74795416
75MP0004808_abnormal_hematopoietic_stem0.69748841
76MP0008874_decreased_physiological_sensi0.69187594
77MP0002928_abnormal_bile_duct0.67758811
78MP0000604_amyloidosis0.66832853
79MP0000490_abnormal_crypts_of0.65311392
80MP0001986_abnormal_taste_sensitivity0.64936827
81MP0004484_altered_response_of0.64460816
82MP0003656_abnormal_erythrocyte_physiolo0.63790466
83MP0009765_abnormal_xenobiotic_induced0.62951445
84MP0004858_abnormal_nervous_system0.62391013
85MP0003252_abnormal_bile_duct0.61330243
86MP0002006_tumorigenesis0.61079799
87MP0002133_abnormal_respiratory_system0.59927878
88MP0005388_respiratory_system_phenotype0.59927878
89MP0003795_abnormal_bone_structure0.59893348
90MP0003878_abnormal_ear_physiology0.58726661
91MP0005377_hearing/vestibular/ear_phenot0.58726661
92MP0003806_abnormal_nucleotide_metabolis0.58224883
93MP0000249_abnormal_blood_vessel0.57892687
94MP0002332_abnormal_exercise_endurance0.57320045
95MP0003787_abnormal_imprinting0.57214712
96MP0005248_abnormal_Harderian_gland0.56661267
97MP0001853_heart_inflammation0.56021242
98MP0001958_emphysema0.53102157
99MP0005319_abnormal_enzyme/_coenzyme0.53023104
100MP0005376_homeostasis/metabolism_phenot0.51501419

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.26025002
2Myositis (HP:0100614)6.49992213
3Recurrent abscess formation (HP:0002722)6.38578538
4Orchitis (HP:0100796)6.38316347
5Recurrent bacterial skin infections (HP:0005406)6.26522557
6Retrobulbar optic neuritis (HP:0100654)6.01149287
7Optic neuritis (HP:0100653)6.01149287
8Abnormality of macrophages (HP:0004311)5.41167786
9Recurrent gram-negative bacterial infections (HP:0005420)5.37283045
10Stomatitis (HP:0010280)5.01411159
11Gastrointestinal infarctions (HP:0005244)4.89963970
12Elevated erythrocyte sedimentation rate (HP:0003565)4.85056536
13Keratoconjunctivitis sicca (HP:0001097)4.44947480
14Recurrent fungal infections (HP:0002841)4.37120891
15Chronic obstructive pulmonary disease (HP:0006510)4.30874502
16Obstructive lung disease (HP:0006536)4.30874502
17Mediastinal lymphadenopathy (HP:0100721)4.23008443
18Meningitis (HP:0001287)4.14570865
19Keratoconjunctivitis (HP:0001096)4.12174398
20Recurrent skin infections (HP:0001581)4.12059059
21Encephalitis (HP:0002383)4.05996650
22Abnormal delayed hypersensitivity skin test (HP:0002963)4.04298910
23Gingivitis (HP:0000230)3.96595441
24Hypochromic microcytic anemia (HP:0004840)3.92449365
25Spontaneous hematomas (HP:0007420)3.90379466
26Peritonitis (HP:0002586)3.72999929
27Recurrent cutaneous fungal infections (HP:0011370)3.70405193
28Chronic mucocutaneous candidiasis (HP:0002728)3.70405193
29Urticaria (HP:0001025)3.68232478
30Vasculitis (HP:0002633)3.57679107
31Increased IgE level (HP:0003212)3.56714727
32Chest pain (HP:0100749)3.48910963
33Hypochromic anemia (HP:0001931)3.39222827
34Cellulitis (HP:0100658)3.31385007
35T lymphocytopenia (HP:0005403)3.30569892
36Episodic fever (HP:0001954)3.27705407
37Hemoptysis (HP:0002105)3.24150681
38Abnormality of T cell number (HP:0011839)3.21047815
39Arterial thrombosis (HP:0004420)3.18512555
40Gingival bleeding (HP:0000225)3.14544425
41Prolonged bleeding time (HP:0003010)3.08769154
42Anorexia (HP:0002039)3.04064442
43Pulmonary infiltrates (HP:0002113)3.03040016
44Leukocytosis (HP:0001974)2.93997614
45Pulmonary embolism (HP:0002204)2.93811145
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82599620
47Abnormality of T cells (HP:0002843)2.70350279
48Amyloidosis (HP:0011034)2.66246603
49Increased IgM level (HP:0003496)2.63615063
50Abnormality of the peritoneum (HP:0002585)2.62346505
51Epistaxis (HP:0000421)2.61490440
52Osteomyelitis (HP:0002754)2.58755754
53Inflammation of the large intestine (HP:0002037)2.58447985
54Microcytic anemia (HP:0001935)2.53665629
55Abnormality of the pleura (HP:0002103)2.53605273
56Gangrene (HP:0100758)2.51967380
57Granulocytopenia (HP:0001913)2.51665301
58Recurrent viral infections (HP:0004429)2.49141956
59Gastrointestinal inflammation (HP:0004386)2.48341807
60Sepsis (HP:0100806)2.48182382
61Abnormality of the endocardium (HP:0004306)2.40458264
62Pustule (HP:0200039)2.34514421
63Subacute progressive viral hepatitis (HP:0006572)2.30821870
64Panhypogammaglobulinemia (HP:0003139)2.29141711
65Acute hepatic failure (HP:0006554)2.26566467
66Keratitis (HP:0000491)2.25206707
67Glomerulopathy (HP:0100820)2.24493883
68Abnormality of T cell physiology (HP:0011840)2.21078659
69Lymphopenia (HP:0001888)2.18136354
70Eosinophilia (HP:0001880)2.18015171
71Hypergammaglobulinemia (HP:0010702)2.17959381
72Petechiae (HP:0000967)2.17107316
73Chronic otitis media (HP:0000389)2.16117101
74Acne (HP:0001061)2.14180097
75Skin ulcer (HP:0200042)2.13534057
76Vertigo (HP:0002321)2.11451973
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.08299602
78Abnormality of the pericardium (HP:0001697)2.06497162
79Slow saccadic eye movements (HP:0000514)2.05876112
80Viral hepatitis (HP:0006562)2.05747066
81Cheilitis (HP:0100825)2.00679196
82Metaphyseal cupping (HP:0003021)1.98675228
83Premature loss of primary teeth (HP:0006323)1.94263392
84Abnormal platelet volume (HP:0011876)1.93847056
85Difficulty running (HP:0009046)1.93747201
86Recurrent bronchitis (HP:0002837)1.90386859
87Recurrent pneumonia (HP:0006532)1.89924843
88Hepatosplenomegaly (HP:0001433)1.86902652
89Segmental peripheral demyelination/remyelination (HP:0003481)1.85928324
90Thrombophlebitis (HP:0004418)1.83334766
91Hypermelanotic macule (HP:0001034)1.82917751
92IgM deficiency (HP:0002850)1.82278907
93Skin rash (HP:0000988)1.82005747
94Abnormality of eosinophils (HP:0001879)1.81914329
95Polyneuropathy (HP:0001271)1.80635476
96Nasal polyposis (HP:0100582)1.80379302
97Toxemia of pregnancy (HP:0100603)1.80020375
98Colitis (HP:0002583)1.79424787
99Polycythemia (HP:0001901)1.78624263
100Papilledema (HP:0001085)1.74386293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.00665319
2IRAK43.60294885
3BLK3.33997481
4MAP2K33.21121432
5MAP4K13.19057928
6TYK22.94612663
7CSK2.93530422
8ERN12.86864409
9EPHB12.69584974
10FES2.54093872
11GRK62.31434515
12TNK22.30382777
13ZAP702.01909391
14TAOK11.86091319
15JAK31.83237168
16FGR1.81640056
17MAP3K31.81236388
18HCK1.81120905
19BTK1.77249410
20TXK1.70707002
21PRPF4B1.67839576
22KSR21.65004244
23JAK21.62093838
24YES11.57930227
25SYK1.54466363
26MAP3K111.52906806
27IKBKE1.43078470
28JAK11.40779236
29LYN1.39650979
30MAP3K11.35325855
31IRAK11.23385163
32MAP3K141.23234605
33SIK31.22456825
34TAOK31.17121736
35LCK1.10859068
36MAP3K21.10618604
37MAP3K61.10478770
38PTK61.09893487
39TBK11.07642539
40IRAK21.04897948
41MARK21.04183298
42MATK1.00815634
43CDK190.99060271
44MAP3K130.98959503
45CSF1R0.98292270
46ITK0.96160906
47KIT0.95023337
48MARK30.94574213
49PRKD20.94173255
50LRRK20.93166553
51MAP2K40.90881610
52STK100.88147278
53PDK10.84595838
54PTK2B0.82063724
55FGFR30.80303958
56EPHA30.78629125
57TRIB30.76385409
58TEC0.74750088
59DYRK1B0.74029374
60SIK20.73405220
61PDPK10.73172017
62BMPR20.72740642
63FGFR40.72618402
64FYN0.72275313
65RAF10.72196538
66STK110.71648078
67SMG10.71485332
68TGFBR20.69062866
69KSR10.68963673
70PIK3CG0.68515966
71MAP3K70.66553873
72MAP3K50.66093379
73TESK20.63946768
74TAOK20.62010236
75STK380.60597000
76SGK30.58534231
77RET0.56686975
78NLK0.55969943
79MAP2K60.53873952
80PRKCQ0.50034773
81MAPK120.48870489
82DYRK30.48735679
83IKBKB0.48539932
84DAPK20.47742961
85HIPK20.47063702
86WNK10.44083994
87SGK20.43569398
88PRKCZ0.41104677
89MAPKAPK20.39216125
90PRKG20.38340223
91CDC42BPA0.37908557
92MAPK70.37368273
93PIM10.36694427
94RPS6KL10.36164518
95RPS6KC10.36164518
96ALK0.34683710
97CAMKK10.34066039
98RPS6KA60.30816557
99SIK10.30327809
100CAMKK20.29268945

Predicted pathways (KEGG)

RankGene SetZ-score
1* Osteoclast differentiation_Homo sapiens_hsa043803.05359201
2* Leishmaniasis_Homo sapiens_hsa051402.96655823
3* Staphylococcus aureus infection_Homo sapiens_hsa051502.62338127
4* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.51042841
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.33831015
6B cell receptor signaling pathway_Homo sapiens_hsa046622.29266310
7* Tuberculosis_Homo sapiens_hsa051522.18526602
8Graft-versus-host disease_Homo sapiens_hsa053322.16130555
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12836366
10Measles_Homo sapiens_hsa051622.07284814
11Allograft rejection_Homo sapiens_hsa053302.07175242
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97300437
13Autoimmune thyroid disease_Homo sapiens_hsa053201.95441215
14Primary immunodeficiency_Homo sapiens_hsa053401.92918214
15Malaria_Homo sapiens_hsa051441.90877140
16Chemokine signaling pathway_Homo sapiens_hsa040621.85000892
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81176833
18Acute myeloid leukemia_Homo sapiens_hsa052211.76119338
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66059944
20T cell receptor signaling pathway_Homo sapiens_hsa046601.62425069
21Legionellosis_Homo sapiens_hsa051341.61049660
22Influenza A_Homo sapiens_hsa051641.58334415
23Antigen processing and presentation_Homo sapiens_hsa046121.54861075
24Type I diabetes mellitus_Homo sapiens_hsa049401.53681270
25Hematopoietic cell lineage_Homo sapiens_hsa046401.49388004
26Toxoplasmosis_Homo sapiens_hsa051451.49178192
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.48220487
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.44714705
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42415228
30* Phagosome_Homo sapiens_hsa041451.41900657
31Viral myocarditis_Homo sapiens_hsa054161.41213364
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40553981
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38969063
34Non-small cell lung cancer_Homo sapiens_hsa052231.38664282
35Herpes simplex infection_Homo sapiens_hsa051681.37922167
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.37448609
37African trypanosomiasis_Homo sapiens_hsa051431.34716598
38Hepatitis C_Homo sapiens_hsa051601.24721192
39Hepatitis B_Homo sapiens_hsa051611.23715618
40TNF signaling pathway_Homo sapiens_hsa046681.21028760
41Platelet activation_Homo sapiens_hsa046111.16166548
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14508510
43Pancreatic cancer_Homo sapiens_hsa052121.10533607
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05853891
45VEGF signaling pathway_Homo sapiens_hsa043701.02372762
46Chronic myeloid leukemia_Homo sapiens_hsa052201.01373172
47Apoptosis_Homo sapiens_hsa042100.98939558
48Salmonella infection_Homo sapiens_hsa051320.98774067
49Shigellosis_Homo sapiens_hsa051310.97092788
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94827909
51Prolactin signaling pathway_Homo sapiens_hsa049170.94555503
52Renal cell carcinoma_Homo sapiens_hsa052110.93879849
53Pertussis_Homo sapiens_hsa051330.92521944
54Endocytosis_Homo sapiens_hsa041440.91086355
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90527134
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85955802
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.83728986
58FoxO signaling pathway_Homo sapiens_hsa040680.80894415
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79876727
60Endometrial cancer_Homo sapiens_hsa052130.78453428
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78220548
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.77877925
63Notch signaling pathway_Homo sapiens_hsa043300.77078071
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.76804971
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76483447
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.72961910
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72649133
68Dorso-ventral axis formation_Homo sapiens_hsa043200.72564597
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71950460
70Viral carcinogenesis_Homo sapiens_hsa052030.69323391
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67640408
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66804923
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.65410027
74Choline metabolism in cancer_Homo sapiens_hsa052310.65163466
75GnRH signaling pathway_Homo sapiens_hsa049120.63017542
76Regulation of autophagy_Homo sapiens_hsa041400.62636980
77Amoebiasis_Homo sapiens_hsa051460.61388439
78Rheumatoid arthritis_Homo sapiens_hsa053230.61296708
79Epstein-Barr virus infection_Homo sapiens_hsa051690.60682228
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60157589
81Inositol phosphate metabolism_Homo sapiens_hsa005620.59498986
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58207081
83Colorectal cancer_Homo sapiens_hsa052100.57948584
84HIF-1 signaling pathway_Homo sapiens_hsa040660.56590395
85mTOR signaling pathway_Homo sapiens_hsa041500.56045242
86Rap1 signaling pathway_Homo sapiens_hsa040150.55181069
87Insulin resistance_Homo sapiens_hsa049310.53982076
88ErbB signaling pathway_Homo sapiens_hsa040120.51737426
89Asthma_Homo sapiens_hsa053100.51425509
90Other glycan degradation_Homo sapiens_hsa005110.50217479
91MAPK signaling pathway_Homo sapiens_hsa040100.48622816
92Type II diabetes mellitus_Homo sapiens_hsa049300.48020498
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45951158
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.44109290
95HTLV-I infection_Homo sapiens_hsa051660.43472494
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43452989
97Glioma_Homo sapiens_hsa052140.42765611
98Prostate cancer_Homo sapiens_hsa052150.41947555
99Estrogen signaling pathway_Homo sapiens_hsa049150.41302077
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39641034

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