FCHSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of bacterium (GO:0016045)5.22554412
2detection of other organism (GO:0098543)5.16051943
3keratinization (GO:0031424)5.14266468
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05058410
5negative regulation of cell killing (GO:0031342)4.86026857
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86026857
7positive regulation of cellular amide metabolic process (GO:0034250)4.48163998
8positive regulation by symbiont of host defense response (GO:0052509)4.44883148
9modulation by symbiont of host defense response (GO:0052031)4.44883148
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44883148
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44883148
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.44883148
13modulation by symbiont of host immune response (GO:0052553)4.44883148
14neuron cell-cell adhesion (GO:0007158)4.19165991
15leukocyte aggregation (GO:0070486)4.08077701
16detection of external biotic stimulus (GO:0098581)4.03292008
17macrophage activation involved in immune response (GO:0002281)3.86850333
18neutrophil activation involved in immune response (GO:0002283)3.85066326
19negative regulation of erythrocyte differentiation (GO:0045647)3.80667041
20response to peptidoglycan (GO:0032494)3.67441439
21positive regulation of gamma-delta T cell activation (GO:0046645)3.64222440
22response to muramyl dipeptide (GO:0032495)3.56283679
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51662043
24positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.49713575
25cellular extravasation (GO:0045123)3.49332742
26detection of biotic stimulus (GO:0009595)3.49030056
27postsynaptic membrane organization (GO:0001941)3.44318773
28synaptic vesicle exocytosis (GO:0016079)3.43588800
29vocalization behavior (GO:0071625)3.36185923
30response to type I interferon (GO:0034340)3.30258831
31type I interferon signaling pathway (GO:0060337)3.29161167
32cellular response to type I interferon (GO:0071357)3.29161167
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26599606
34mannose metabolic process (GO:0006013)3.23671905
35negative regulation of interleukin-12 production (GO:0032695)3.22811587
36regulation of interferon-beta biosynthetic process (GO:0045357)3.22179100
37negative regulation of leukocyte mediated immunity (GO:0002704)3.21397728
38germinal center formation (GO:0002467)3.21071144
39exploration behavior (GO:0035640)3.18425567
40regulation of mast cell degranulation (GO:0043304)3.15900119
41regulation of gamma-delta T cell differentiation (GO:0045586)3.11948243
42detection of molecule of bacterial origin (GO:0032490)3.10058030
43establishment of skin barrier (GO:0061436)3.09547162
44regulation of T cell tolerance induction (GO:0002664)3.07120972
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06976066
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05914014
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04831602
48immunoglobulin mediated immune response (GO:0016064)3.04760418
49regulation of gamma-delta T cell activation (GO:0046643)3.04381450
50regulation of B cell differentiation (GO:0045577)3.03404515
51positive regulation of humoral immune response (GO:0002922)3.02352075
52positive thymic T cell selection (GO:0045059)3.01591271
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01062197
54positive T cell selection (GO:0043368)3.00293160
55regulation of glutamate receptor signaling pathway (GO:1900449)2.99842047
56positive regulation of B cell differentiation (GO:0045579)2.99401648
57tolerance induction (GO:0002507)2.98936717
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97477488
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97452835
60response to host immune response (GO:0052572)2.97452835
61defense response to protozoan (GO:0042832)2.97206977
62regulation of mast cell activation involved in immune response (GO:0033006)2.96404575
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96111225
64response to host (GO:0075136)2.96111225
65response to host defenses (GO:0052200)2.96111225
66neutrophil activation (GO:0042119)2.94551073
67regulation of leukocyte degranulation (GO:0043300)2.92861990
68myeloid cell activation involved in immune response (GO:0002275)2.90528508
69regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87664143
70layer formation in cerebral cortex (GO:0021819)2.86535023
71protein localization to synapse (GO:0035418)2.86346451
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.84206426
73antigen processing and presentation via MHC class Ib (GO:0002475)2.84156014
74regulation of regulatory T cell differentiation (GO:0045589)2.83138141
75glutamate secretion (GO:0014047)2.82349045
76regulation of cellular amide metabolic process (GO:0034248)2.82183173
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80980844
78negative regulation of interleukin-6 production (GO:0032715)2.79481769
79regulation of water loss via skin (GO:0033561)2.78977808
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77858944
81interferon-gamma-mediated signaling pathway (GO:0060333)2.77816999
82regulation of tolerance induction (GO:0002643)2.76944859
83granulocyte activation (GO:0036230)2.76798668
84dendritic cell migration (GO:0036336)2.76378378
85response to interleukin-15 (GO:0070672)2.75033039
86cellular response to interleukin-15 (GO:0071350)2.74450128
87regulation of MHC class I biosynthetic process (GO:0045343)2.73237005
88response to protozoan (GO:0001562)2.73100178
89defense response to Gram-negative bacterium (GO:0050829)2.72930951
90respiratory burst (GO:0045730)2.72751595
91neuron recognition (GO:0008038)2.72239045
92positive regulation of interleukin-8 secretion (GO:2000484)2.72175861
93microglial cell activation (GO:0001774)2.71336972
94macrophage activation (GO:0042116)2.70877505
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70478312
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.70210818
97regulation of vesicle fusion (GO:0031338)2.66279358
98response to pheromone (GO:0019236)2.65902782
99regulation of T-helper 2 cell differentiation (GO:0045628)2.65169577
100negative regulation of phagocytosis (GO:0050765)2.65098669
101production of molecular mediator involved in inflammatory response (GO:0002532)2.63992448
102negative T cell selection (GO:0043383)2.63850650
103negative regulation of glycoprotein biosynthetic process (GO:0010561)2.63848583
104regulation of alpha-beta T cell proliferation (GO:0046640)2.63632275
105regulation of isotype switching to IgG isotypes (GO:0048302)2.61414646
106negative regulation of innate immune response (GO:0045824)2.61260020
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61165198
108positive regulation of synapse assembly (GO:0051965)2.61029002
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60654701
110locomotory exploration behavior (GO:0035641)2.59668232
111presynaptic membrane assembly (GO:0097105)2.59496396
112glutamate receptor signaling pathway (GO:0007215)2.59369339
113behavioral response to nicotine (GO:0035095)2.59085786
114regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57933189
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.57508511
116regulation of synaptic vesicle exocytosis (GO:2000300)2.55849564
117regulation of interleukin-12 biosynthetic process (GO:0045075)2.55671691
118central nervous system projection neuron axonogenesis (GO:0021952)2.53222027
119negative thymic T cell selection (GO:0045060)2.53153306
120synaptic vesicle endocytosis (GO:0048488)2.50605418
121response to histamine (GO:0034776)2.49355214
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.48571082
123negative regulation of microtubule polymerization (GO:0031115)2.47911651
124cell migration in hindbrain (GO:0021535)2.47442522
125opioid receptor signaling pathway (GO:0038003)2.47132684
126proline transport (GO:0015824)2.45530906
127histone H3-K4 trimethylation (GO:0080182)2.42101166
128synapse assembly (GO:0007416)2.40112099
129neurotransmitter secretion (GO:0007269)2.40039455
130mature B cell differentiation (GO:0002335)2.38948770
131axon extension (GO:0048675)2.38649993
132NIK/NF-kappaB signaling (GO:0038061)2.37287519
133T cell selection (GO:0045058)2.37056873
134dendritic spine morphogenesis (GO:0060997)2.33903430
135thymic T cell selection (GO:0045061)2.33002452
136axonal fasciculation (GO:0007413)2.30285736
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29393854
138positive regulation of fibroblast migration (GO:0010763)2.28213281
139regulation of B cell receptor signaling pathway (GO:0050855)2.27719475
140regulation of synaptic transmission, GABAergic (GO:0032228)2.25568835
141regulation of synaptic vesicle transport (GO:1902803)2.25485109
142synaptic vesicle maturation (GO:0016188)2.25285546
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.24750804
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.24750804
145activated T cell proliferation (GO:0050798)2.23589798
146negative regulation of T cell mediated immunity (GO:0002710)2.23321705
147synaptic transmission, glutamatergic (GO:0035249)2.22469495
148regulation of postsynaptic membrane potential (GO:0060078)2.22017784
149dendrite morphogenesis (GO:0048813)2.21396066
150prepulse inhibition (GO:0060134)2.20285402
151antigen processing and presentation of endogenous antigen (GO:0019883)2.19449884
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.18130144
153presynaptic membrane organization (GO:0097090)2.16456849
154T cell migration (GO:0072678)2.16040673
155synaptic vesicle transport (GO:0048489)2.15612264
156establishment of synaptic vesicle localization (GO:0097480)2.15612264
157regulation of excitatory postsynaptic membrane potential (GO:0060079)2.14846989
158dopamine biosynthetic process (GO:0042416)2.13859034
159regulation of dopamine secretion (GO:0014059)2.13354012
160membrane hyperpolarization (GO:0060081)2.12883180
161B cell receptor signaling pathway (GO:0050853)2.12033443
162positive regulation of vesicle fusion (GO:0031340)2.11938347
163regulation of synapse structural plasticity (GO:0051823)2.11599030
164neuron-neuron synaptic transmission (GO:0007270)2.08944427
165cerebellar Purkinje cell differentiation (GO:0021702)2.06499971
166positive regulation of filopodium assembly (GO:0051491)2.05990201
167negative regulation of lymphocyte mediated immunity (GO:0002707)2.05692648
168regulation of synapse assembly (GO:0051963)2.05655617
169clathrin coat assembly (GO:0048268)2.04986975
170positive regulation of CREB transcription factor activity (GO:0032793)2.04931347
171synaptic transmission, cholinergic (GO:0007271)2.03573374
172regulation of filopodium assembly (GO:0051489)2.03255902
173T cell homeostasis (GO:0043029)2.02972029
174positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.02565714
175membrane depolarization (GO:0051899)2.01758290
176negative regulation of T-helper cell differentiation (GO:0045623)2.01709988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72579142
2VDR_21846776_ChIP-Seq_THP-1_Human2.89793893
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68708990
4GBX2_23144817_ChIP-Seq_PC3_Human2.67419311
5MYC_22102868_ChIP-Seq_BL_Human2.65927654
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58701324
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54592996
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53617162
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49605656
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.44846032
11VDR_24763502_ChIP-Seq_THP-1_Human2.42271301
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.42196002
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41495548
14MAF_26560356_Chip-Seq_TH1_Human2.35785837
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.33415746
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21631430
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20542777
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19026752
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.17850770
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16010732
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14493024
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14407829
23UTX_26944678_Chip-Seq_JUKART_Human2.14001363
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13761017
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13761017
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13000348
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11060281
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.10079727
29SPI1_23127762_ChIP-Seq_K562_Human2.10071065
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10055657
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08242061
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05869318
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.05539208
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05175072
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03273298
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03211310
37MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01373996
38EZH2_27294783_Chip-Seq_ESCs_Mouse2.00232580
39DROSHA_22980978_ChIP-Seq_HELA_Human1.99919187
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99461419
41MYB_26560356_Chip-Seq_TH2_Human1.95899830
42SPI1_23547873_ChIP-Seq_NB4_Human1.94542275
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94188983
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92376434
45LXR_22292898_ChIP-Seq_THP-1_Human1.92369968
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.89916926
47MAF_26560356_Chip-Seq_TH2_Human1.88465827
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88230498
49MYB_26560356_Chip-Seq_TH1_Human1.84972420
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84957185
51REST_21632747_ChIP-Seq_MESCs_Mouse1.82424176
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77367162
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73469079
54* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68157769
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65026532
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63622180
57AR_21572438_ChIP-Seq_LNCaP_Human1.62992609
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.59580333
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58728047
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58482400
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56911024
62TAF15_26573619_Chip-Seq_HEK293_Human1.55425181
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50436945
64RUNX_20019798_ChIP-Seq_JUKART_Human1.50028968
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49508846
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49223805
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46535309
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.45000293
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44972964
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39839262
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37958749
72RACK7_27058665_Chip-Seq_MCF-7_Human1.36759473
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36305142
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34488775
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.34173702
76IGF1R_20145208_ChIP-Seq_DFB_Human1.34012166
77RNF2_27304074_Chip-Seq_NSC_Mouse1.32099169
78SCL_19346495_ChIP-Seq_HPC-7_Human1.31615202
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30958909
80GATA3_27048872_Chip-Seq_THYMUS_Human1.30213975
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30009977
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29153104
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.27434589
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26656464
85VDR_24787735_ChIP-Seq_THP-1_Human1.24856878
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24001569
87GATA1_19941826_ChIP-Seq_K562_Human1.23441281
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22887736
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21104736
90* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20817824
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20332366
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.19748278
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19436693
94NCOR1_26117541_ChIP-Seq_K562_Human1.19313580
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19215179
96BCOR_27268052_Chip-Seq_Bcells_Human1.19140655
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.19011342
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18237982
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18230435
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18077803
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18072874
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17603314
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.16987808
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16647376
105BCL6_27268052_Chip-Seq_Bcells_Human1.16280566
106SMAD4_21799915_ChIP-Seq_A2780_Human1.15742386
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15619382
108* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13666997
109PU_27001747_Chip-Seq_BMDM_Mouse1.13629879
110AHR_22903824_ChIP-Seq_MCF-7_Human1.13584150
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12706708
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.11379409
113KDM2B_26808549_Chip-Seq_K562_Human1.11360971
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.11069076
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10823463
116KDM2B_26808549_Chip-Seq_DND41_Human1.09049151
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08711018
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08423373
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08332975
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.08213139
121BP1_19119308_ChIP-ChIP_Hs578T_Human1.07528425
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06932827
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.04002128
124* P300_19829295_ChIP-Seq_ESCs_Human1.03863593
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02868278
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02854589
127TP53_18474530_ChIP-ChIP_U2OS_Human1.02171913
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01772971
129TP53_16413492_ChIP-PET_HCT116_Human1.00702214
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00446482
131AR_25329375_ChIP-Seq_VCAP_Human0.99746769
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.99717014
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.99269102
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98502554
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98350288
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98259861
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98259861
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97944591
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97812894
140P68_20966046_ChIP-Seq_HELA_Human0.97741278
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97612780
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97385664
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97326579
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.96887418
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96355809
146SMC4_20622854_ChIP-Seq_HELA_Human0.95844294
147ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95292665
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.95222660
149GATA3_26560356_Chip-Seq_TH2_Human0.93286908
150* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93230890
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93080795
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91993592
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91993592
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.91682433
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91299806
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91157120
157ZNF274_21170338_ChIP-Seq_K562_Hela0.90023716
158TCF7_22412390_ChIP-Seq_EML_Mouse0.88479614
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88182560
160SOX2_21211035_ChIP-Seq_LN229_Gbm0.88181537
161P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87285546
162IRF8_27001747_Chip-Seq_BMDM_Mouse0.86944859
163AR_19668381_ChIP-Seq_PC3_Human0.86406684
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85940603
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84033407
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83835859
167RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83739578
168RXR_22108803_ChIP-Seq_LS180_Human0.83410662
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83250283
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83203119
171KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82640811
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.82401295
173SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82379539
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82173322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.06156553
2MP0003880_abnormal_central_pattern3.47985892
3MP0003724_increased_susceptibility_to3.03771429
4MP0001188_hyperpigmentation2.93113079
5MP0003191_abnormal_cellular_cholesterol2.78285657
6MP0001968_abnormal_touch/_nociception2.69678170
7MP0003635_abnormal_synaptic_transmissio2.61747436
8MP0008260_abnormal_autophagy2.58602740
9MP0005423_abnormal_somatic_nervous2.52187427
10MP0000569_abnormal_digit_pigmentation2.42794092
11MP0002735_abnormal_chemical_nociception2.27868860
12MP0002736_abnormal_nociception_after2.25343122
13MP0006276_abnormal_autonomic_nervous2.09802201
14MP0009745_abnormal_behavioral_response2.07762928
15MP0003303_peritoneal_inflammation2.07151529
16MP0005174_abnormal_tail_pigmentation2.00795413
17MP0005451_abnormal_body_composition1.92401401
18MP0002064_seizures1.89176698
19MP0004510_myositis1.85442312
20MP0002405_respiratory_system_inflammati1.84800149
21MP0002733_abnormal_thermal_nociception1.82606809
22MP0003705_abnormal_hypodermis_morpholog1.82216312
23MP0001533_abnormal_skeleton_physiology1.82145188
24MP0002063_abnormal_learning/memory/cond1.81402332
25MP0001486_abnormal_startle_reflex1.77402015
26MP0009333_abnormal_splenocyte_physiolog1.73950381
27MP0002572_abnormal_emotion/affect_behav1.72795837
28MP0002734_abnormal_mechanical_nocicepti1.70406779
29MP0001440_abnormal_grooming_behavior1.69311364
30MP0001970_abnormal_pain_threshold1.69109895
31MP0002396_abnormal_hematopoietic_system1.69013535
32MP0005275_abnormal_skin_tensile1.67807825
33MP0004742_abnormal_vestibular_system1.66179207
34MP0005058_abnormal_lysosome_morphology1.66058027
35MP0009046_muscle_twitch1.64920008
36MP0004858_abnormal_nervous_system1.64286113
37MP0001501_abnormal_sleep_pattern1.62220240
38MP0010234_abnormal_vibrissa_follicle1.61178095
39MP0002184_abnormal_innervation1.60450756
40MP0005501_abnormal_skin_physiology1.59391852
41MP0005671_abnormal_response_to1.59066401
42MP0003453_abnormal_keratinocyte_physiol1.57566193
43MP0005387_immune_system_phenotype1.56869199
44MP0001790_abnormal_immune_system1.56869199
45MP0000015_abnormal_ear_pigmentation1.53939319
46MP0003300_gastrointestinal_ulcer1.51008541
47MP0000778_abnormal_nervous_system1.50955441
48MP0001851_eye_inflammation1.48948635
49MP0002722_abnormal_immune_system1.48580071
50MP0001835_abnormal_antigen_presentation1.47972950
51MP0001845_abnormal_inflammatory_respons1.46537599
52MP0001800_abnormal_humoral_immune1.46232954
53MP0002067_abnormal_sensory_capabilities1.46002018
54MP0000858_altered_metastatic_potential1.45839695
55MP0000689_abnormal_spleen_morphology1.44188201
56MP0003436_decreased_susceptibility_to1.43965982
57MP0005310_abnormal_salivary_gland1.43195882
58MP0002557_abnormal_social/conspecific_i1.43003584
59MP0009278_abnormal_bone_marrow1.40906997
60MP0003828_pulmonary_edema1.39150550
61MP0003763_abnormal_thymus_physiology1.39049960
62MP0001986_abnormal_taste_sensitivity1.38408187
63MP0001905_abnormal_dopamine_level1.38267112
64MP0003787_abnormal_imprinting1.36058378
65MP0002429_abnormal_blood_cell1.35677669
66MP0003566_abnormal_cell_adhesion1.35017392
67MP0005409_darkened_coat_color1.34484455
68MP0008961_abnormal_basal_metabolism1.32799887
69MP0003866_abnormal_defecation1.32331644
70MP0002998_abnormal_bone_remodeling1.31894432
71MP0005000_abnormal_immune_tolerance1.30981311
72MP0002272_abnormal_nervous_system1.30227488
73MP0001348_abnormal_lacrimal_gland1.25912708
74MP0002933_joint_inflammation1.23326695
75MP0003172_abnormal_lysosome_physiology1.22857260
76MP0001545_abnormal_hematopoietic_system1.22570817
77MP0005397_hematopoietic_system_phenotyp1.22570817
78MP0003122_maternal_imprinting1.22491315
79MP0002420_abnormal_adaptive_immunity1.21680547
80MP0001819_abnormal_immune_cell1.21629159
81MP0004270_analgesia1.21526579
82MP0002452_abnormal_antigen_presenting1.19783981
83MP0009785_altered_susceptibility_to1.18646877
84MP0003183_abnormal_peptide_metabolism1.18515362
85MP0002723_abnormal_immune_serum1.17532779
86MP0002132_abnormal_respiratory_system1.15488833
87MP0008569_lethality_at_weaning1.13823969
88MP0005645_abnormal_hypothalamus_physiol1.12504384
89MP0008469_abnormal_protein_level1.11662302
90MP0004811_abnormal_neuron_physiology1.09879578
91MP0001216_abnormal_epidermal_layer1.09643372
92MP0000685_abnormal_immune_system1.07845232
93MP0005386_behavior/neurological_phenoty1.07080451
94MP0004924_abnormal_behavior1.07080451
95MP0003279_aneurysm1.06762564
96MP0000579_abnormal_nail_morphology1.05975235
97MP0001958_emphysema1.05464908
98MP0004947_skin_inflammation1.05352421
99MP0005076_abnormal_cell_differentiation1.05256390
100MP0002102_abnormal_ear_morphology1.04578661
101MP0003045_fibrosis1.04265100
102MP0009840_abnormal_foam_cell1.03606650
103MP0000955_abnormal_spinal_cord1.03051989
104MP0002060_abnormal_skin_morphology1.03023194
105MP0002398_abnormal_bone_marrow1.00051806
106MP0005075_abnormal_melanosome_morpholog0.99808506
107MP0003879_abnormal_hair_cell0.99352371
108MP0001502_abnormal_circadian_rhythm0.98650860
109MP0004883_abnormal_blood_vessel0.97749151
110MP0002254_reproductive_system_inflammat0.96962419
111MP0002928_abnormal_bile_duct0.94089397
112MP0002148_abnormal_hypersensitivity_rea0.94080878
113MP0005025_abnormal_response_to0.93764289
114MP0005390_skeleton_phenotype0.93736417
115MP0002138_abnormal_hepatobiliary_system0.92436392
116MP0001664_abnormal_digestion0.92018670
117MP0001853_heart_inflammation0.91068026
118MP0009931_abnormal_skin_appearance0.91064139
119MP0005464_abnormal_platelet_physiology0.90245692
120MP0005023_abnormal_wound_healing0.90012879
121MP0005164_abnormal_response_to0.88029261
122MP0000716_abnormal_immune_system0.86647605
123MP0002882_abnormal_neuron_morphology0.86577747
124MP0002909_abnormal_adrenal_gland0.85896156
125MP0002796_impaired_skin_barrier0.85891418
126MP0003656_abnormal_erythrocyte_physiolo0.84340812
127MP0002166_altered_tumor_susceptibility0.82399953
128MP0002638_abnormal_pupillary_reflex0.81341953
129MP0009764_decreased_sensitivity_to0.79172050
130MP0003448_altered_tumor_morphology0.79131012
131MP0001873_stomach_inflammation0.78777002
132MP0002419_abnormal_innate_immunity0.77645532
133MP0004808_abnormal_hematopoietic_stem0.77408074
134MP0002095_abnormal_skin_pigmentation0.75915918
135MP0008004_abnormal_stomach_pH0.75563682
136MP0000465_gastrointestinal_hemorrhage0.74439175
137MP0001849_ear_inflammation0.73513971
138MP0002066_abnormal_motor_capabilities/c0.71920784
139MP0000703_abnormal_thymus_morphology0.71840498
140MP0006054_spinal_hemorrhage0.70623345
141MP0004185_abnormal_adipocyte_glucose0.70321176
142MP0008874_decreased_physiological_sensi0.69860093
143MP0003795_abnormal_bone_structure0.68821194
144MP0010771_integument_phenotype0.68768611
145MP0000767_abnormal_smooth_muscle0.68252193
146MP0004264_abnormal_extraembryonic_tissu0.67420293
147MP0004142_abnormal_muscle_tone0.65397848
148MP0004381_abnormal_hair_follicle0.65086120
149MP0002751_abnormal_autonomic_nervous0.64907874
150MP0009763_increased_sensitivity_to0.64844199
151MP0000249_abnormal_blood_vessel0.64611777
152MP0002152_abnormal_brain_morphology0.64389115
153MP0001663_abnormal_digestive_system0.64130104
154MP0010155_abnormal_intestine_physiology0.63465325
155MP0005621_abnormal_cell_physiology0.63396155
156MP0009379_abnormal_foot_pigmentation0.62832593
157MP0006082_CNS_inflammation0.61243194
158MP0003091_abnormal_cell_migration0.60635979
159MP0008872_abnormal_physiological_respon0.60552864

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.61208203
2Abnormality of nail color (HP:0100643)4.56066470
3Pustule (HP:0200039)4.11540764
4Abnormality of macrophages (HP:0004311)3.99078593
5Focal motor seizures (HP:0011153)3.92178205
6Focal seizures (HP:0007359)3.86866856
7Limb dystonia (HP:0002451)3.65354152
8Increased IgE level (HP:0003212)3.46059226
9Abnormal hair whorl (HP:0010721)3.42738305
10Visual hallucinations (HP:0002367)3.37263925
11Recurrent skin infections (HP:0001581)3.31275667
12Febrile seizures (HP:0002373)3.22818030
13Spontaneous hematomas (HP:0007420)3.17246991
14Supranuclear gaze palsy (HP:0000605)3.13626862
15Gastrointestinal infarctions (HP:0005244)3.11081518
16Parakeratosis (HP:0001036)3.04334430
17Progressive inability to walk (HP:0002505)2.93216323
18Recurrent gram-negative bacterial infections (HP:0005420)2.91424328
19Colitis (HP:0002583)2.81264696
20Gangrene (HP:0100758)2.79376514
21Urticaria (HP:0001025)2.78069706
22Chronic otitis media (HP:0000389)2.77657834
23Thick nail (HP:0001805)2.76902712
24Gingivitis (HP:0000230)2.74069209
25Atonic seizures (HP:0010819)2.63390844
26Agammaglobulinemia (HP:0004432)2.61386554
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.60776672
28Keratoconjunctivitis sicca (HP:0001097)2.60374642
29T lymphocytopenia (HP:0005403)2.59159245
30Failure to thrive in infancy (HP:0001531)2.58322937
31Epileptic encephalopathy (HP:0200134)2.56994704
32Palmoplantar hyperkeratosis (HP:0000972)2.55691337
33Progressive cerebellar ataxia (HP:0002073)2.55111812
34Hypoventilation (HP:0002791)2.54415654
35Mutism (HP:0002300)2.51314555
36Abnormality of binocular vision (HP:0011514)2.50447618
37Diplopia (HP:0000651)2.50447618
38Pulmonary infiltrates (HP:0002113)2.48933008
39Chest pain (HP:0100749)2.47617809
40Encephalitis (HP:0002383)2.42827410
41Sepsis (HP:0100806)2.42499916
42Epistaxis (HP:0000421)2.42381463
43Abnormality of T cell number (HP:0011839)2.40356589
44Hemoptysis (HP:0002105)2.35773052
45Keratoconjunctivitis (HP:0001096)2.35070628
46Dysostosis multiplex (HP:0000943)2.34960190
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.32409540
48Palmar hyperkeratosis (HP:0010765)2.32293155
49Akinesia (HP:0002304)2.31230084
50Emphysema (HP:0002097)2.30550351
51Peritonitis (HP:0002586)2.27613278
52Skin ulcer (HP:0200042)2.27307635
53Truncal ataxia (HP:0002078)2.27057817
54Panhypogammaglobulinemia (HP:0003139)2.24968503
55Congenital ichthyosiform erythroderma (HP:0007431)2.21883200
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21524070
57Chronic obstructive pulmonary disease (HP:0006510)2.20350964
58Obstructive lung disease (HP:0006536)2.20350964
59Lymphopenia (HP:0001888)2.19211689
60Open mouth (HP:0000194)2.17213192
61Abnormality of T cells (HP:0002843)2.16898610
62Eczematoid dermatitis (HP:0000976)2.15162994
63Recurrent fungal infections (HP:0002841)2.14885176
64Peripheral hypomyelination (HP:0007182)2.13654068
65Chronic sinusitis (HP:0011109)2.13334538
66Plantar hyperkeratosis (HP:0007556)2.12732793
67Myokymia (HP:0002411)2.12520249
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12467184
69Gingival bleeding (HP:0000225)2.11467878
70Absence seizures (HP:0002121)2.07600929
71Osteomyelitis (HP:0002754)2.07438060
72Meningitis (HP:0001287)2.06019350
73Hypoplasia of the brainstem (HP:0002365)2.04438219
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04438219
75Chronic mucocutaneous candidiasis (HP:0002728)2.04119581
76Recurrent cutaneous fungal infections (HP:0011370)2.04119581
77Recurrent abscess formation (HP:0002722)2.03843533
78Exotropia (HP:0000577)2.03412245
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.03378532
80Cellulitis (HP:0100658)2.02154182
81Gastrointestinal stroma tumor (HP:0100723)2.02060588
82Abnormality of T cell physiology (HP:0011840)2.00401032
83Myositis (HP:0100614)1.99315199
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97246486
85Granulocytopenia (HP:0001913)1.96859348
86Elevated erythrocyte sedimentation rate (HP:0003565)1.95923940
87Increased cerebral lipofuscin (HP:0011813)1.95226078
88Viral hepatitis (HP:0006562)1.94575304
89Abnormality of calcium-phosphate metabolism (HP:0100530)1.92845512
90Hypochromic anemia (HP:0001931)1.92226607
91Polyphagia (HP:0002591)1.91800422
92Morphological abnormality of the middle ear (HP:0008609)1.91097319
93Broad face (HP:0000283)1.90960311
94Amblyopia (HP:0000646)1.90546609
95Arterial thrombosis (HP:0004420)1.90026240
96Slow saccadic eye movements (HP:0000514)1.89961843
97Petechiae (HP:0000967)1.89733193
98Submucous cleft hard palate (HP:0000176)1.89566377
99Generalized tonic-clonic seizures (HP:0002069)1.89475040
100Mediastinal lymphadenopathy (HP:0100721)1.88919601
101Narrow nasal bridge (HP:0000446)1.87015459
102Inability to walk (HP:0002540)1.86959117
103Leukocytosis (HP:0001974)1.85677769
104Mucopolysacchariduria (HP:0008155)1.85101231
105Urinary glycosaminoglycan excretion (HP:0003541)1.85101231
106Dilatation of the ascending aorta (HP:0005111)1.84446408
107Interstitial pulmonary disease (HP:0006530)1.84192071
108Broad-based gait (HP:0002136)1.83691565
109Premature loss of primary teeth (HP:0006323)1.82008930
110Abnormality of polysaccharide metabolism (HP:0011012)1.81372489
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81372489
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81372489
113Inflammation of the large intestine (HP:0002037)1.81040425
114Pulmonary embolism (HP:0002204)1.80835340
115Episodic fever (HP:0001954)1.80676934
116Restrictive lung disease (HP:0002091)1.80476654
117Ulnar claw (HP:0001178)1.80407297
118Nasal polyposis (HP:0100582)1.80382484
119Recurrent viral infections (HP:0004429)1.80277275
120Inappropriate behavior (HP:0000719)1.80210483
121Stereotypic behavior (HP:0000733)1.79094478
122Abnormality of the fingertips (HP:0001211)1.77532116
123Vasculitis (HP:0002633)1.77420662
124Lower limb amyotrophy (HP:0007210)1.77412982
125Ectropion (HP:0000656)1.77201398
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.76933129
127Hypergammaglobulinemia (HP:0010702)1.76718654
128Obstructive sleep apnea (HP:0002870)1.76554797
129Spondylolisthesis (HP:0003302)1.76309312
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75618043
131Anorexia (HP:0002039)1.75500708
132Hypotrichosis (HP:0001006)1.74969083
133Malnutrition (HP:0004395)1.74324959
134Agitation (HP:0000713)1.74237209
135Generalized hypopigmentation of hair (HP:0011358)1.73947432
136Loss of speech (HP:0002371)1.73918078
137Abnormal blistering of the skin (HP:0008066)1.73795745
138Recurrent bronchitis (HP:0002837)1.73789313
139Orchitis (HP:0100796)1.73439422
140Genetic anticipation (HP:0003743)1.72364383
141Hemiparesis (HP:0001269)1.70987943
142Gastrointestinal inflammation (HP:0004386)1.70581608
143Retrobulbar optic neuritis (HP:0100654)1.70265518
144Optic neuritis (HP:0100653)1.70265518
145Erythema (HP:0010783)1.68423463
146Absent eyebrow (HP:0002223)1.67165467
147Hypercortisolism (HP:0001578)1.66608342
148Dialeptic seizures (HP:0011146)1.66161255
149Recurrent sinusitis (HP:0011108)1.65518789
150Excessive salivation (HP:0003781)1.65512880
151Drooling (HP:0002307)1.65512880
152Increased IgM level (HP:0003496)1.64538377
153Cheilitis (HP:0100825)1.64223584
154Verrucae (HP:0200043)1.63204911
155Papilloma (HP:0012740)1.63204911
156Stomatitis (HP:0010280)1.62300429
157Prolonged bleeding time (HP:0003010)1.62293586
158Aplasia cutis congenita (HP:0001057)1.60874984
159Poor suck (HP:0002033)1.60305656
160Generalized hypopigmentation (HP:0007513)1.60027535
161Generalized hypotonia (HP:0001290)1.59624034
162Fetal akinesia sequence (HP:0001989)1.59388932
163Hemiplegia (HP:0002301)1.58602958
164Abnormality of the nasal mucosa (HP:0000433)1.57778739
165Iris hypopigmentation (HP:0007730)1.57497059
166Tented upper lip vermilion (HP:0010804)1.55701749
167Popliteal pterygium (HP:0009756)1.55378602
168Sparse scalp hair (HP:0002209)1.54501123
169Depression (HP:0000716)1.54341479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.70470441
2SIK23.65004880
3MAP3K93.23663549
4ERN13.14972767
5MAP2K32.85022319
6PRPF4B2.80975706
7IRAK42.63670335
8EEF2K2.42419913
9RIPK42.37512693
10NTRK32.32672131
11TRIB32.29659204
12CASK2.15563668
13MAP4K12.14043492
14BLK2.13213088
15MAPK132.08869034
16TNIK2.07084718
17MAP2K72.04729660
18MAP3K121.98286242
19FES1.98183378
20MAP3K41.91234806
21NTRK21.90494649
22SIK31.81116749
23MAP3K31.75904546
24MAP3K131.69810451
25KSR21.51699290
26SYK1.50525858
27TXK1.50300139
28SIK11.45046342
29RET1.42791247
30GRK61.41353049
31MINK11.31169383
32CDC42BPA1.28714742
33MARK21.28280354
34SMG11.23709216
35RAF11.21321237
36JAK31.20871409
37GRK51.18943831
38EPHA21.17580599
39ZAP701.16514925
40CDK121.14025998
41CSF1R1.11937814
42IKBKE1.08757202
43MAP3K111.07588873
44HCK1.06942932
45MARK31.06499260
46FGR1.06375322
47PLK21.05984052
48TBK11.00923126
49MAP3K140.97909279
50STK100.97321339
51PTK60.97221207
52TAOK30.96870721
53MAP3K70.95677083
54DMPK0.91833104
55TEC0.90840778
56PAK60.90344841
57KSR10.90126881
58JAK20.87649730
59MAP3K100.84839586
60PTK2B0.84597370
61KIT0.84419366
62IRAK30.83856106
63CDK50.83199882
64TAOK20.82406972
65MAP2K40.82176262
66CAMKK10.81660055
67CSNK1G20.80703534
68FGFR30.80650543
69FGFR40.80561941
70PKN10.80319932
71IRAK10.79268119
72BMX0.77514271
73ITK0.77453010
74PDK10.76244471
75LCK0.75746873
76IRAK20.74159182
77MAP3K20.73004028
78HIPK20.72688920
79MAPK70.71704881
80RPS6KA20.71127750
81YES10.70660876
82RIPK10.70195953
83CDK190.68522808
84PDPK10.68029851
85TTN0.66053473
86CAMK1G0.65403222
87MAPKAPK50.64940397
88TNK20.64497925
89TAOK10.64308366
90ICK0.63745023
91EPHB10.62030893
92CLK10.62007295
93PDGFRB0.61529062
94DAPK20.60828307
95JAK10.60792049
96PHKG20.60365751
97PHKG10.60365751
98DYRK20.59609604
99MAPK120.59561892
100PNCK0.59090442
101LRRK20.58866883
102CSK0.58809526
103CSNK1G30.58340132
104FYN0.57537731
105BMPR20.56944249
106NLK0.56689128
107TLK10.56599181
108RPS6KC10.55469403
109RPS6KL10.55469403
110EPHA30.54832310
111BTK0.54823783
112DYRK1B0.54040095
113CHUK0.52509842
114PRKCH0.52058973
115MST40.51857340
116PAK30.50762771
117LYN0.50372118
118LATS20.49674103
119TGFBR20.49171196
120IKBKB0.49103679
121PDGFRA0.48285498
122GRK70.47981814
123MELK0.47048519
124TYK20.46975757
125PRKD20.46345160
126SGK30.45414381
127MAP3K10.44990971
128RPS6KA60.43215183
129MAPK110.42791746
130NTRK10.41454082
131PIK3CG0.41339943
132MAPKAPK20.39676917
133MAP3K60.39476091
134PIM10.39413728
135ADRBK10.39317065
136STK380.39068951
137WNK10.38579702
138MTOR0.38240485
139PKN20.37282393
140STK110.37133065
141PRKCQ0.36666361
142ALK0.35771472
143CDK40.35387935
144CAMK10.34881768
145MAP2K20.33515825
146TYRO30.32889910
147MAP2K60.32218368
148MAP2K10.32023582
149MATK0.31863211

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.25592753
2Other glycan degradation_Homo sapiens_hsa005112.17949042
3Staphylococcus aureus infection_Homo sapiens_hsa051501.92926355
4Synaptic vesicle cycle_Homo sapiens_hsa047211.87551136
5Autoimmune thyroid disease_Homo sapiens_hsa053201.84818906
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59376926
7Influenza A_Homo sapiens_hsa051641.43584569
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41899571
9B cell receptor signaling pathway_Homo sapiens_hsa046621.40396030
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39680342
11Primary immunodeficiency_Homo sapiens_hsa053401.39645908
12T cell receptor signaling pathway_Homo sapiens_hsa046601.37414258
13Type I diabetes mellitus_Homo sapiens_hsa049401.35628100
14Long-term potentiation_Homo sapiens_hsa047201.34641809
15Cholinergic synapse_Homo sapiens_hsa047251.33925788
16Morphine addiction_Homo sapiens_hsa050321.32950148
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31425982
18Cocaine addiction_Homo sapiens_hsa050301.30434390
19Circadian entrainment_Homo sapiens_hsa047131.29931345
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28562443
21Osteoclast differentiation_Homo sapiens_hsa043801.28185032
22Herpes simplex infection_Homo sapiens_hsa051681.27387832
23Antigen processing and presentation_Homo sapiens_hsa046121.26424867
24Glutamatergic synapse_Homo sapiens_hsa047241.26036443
25Malaria_Homo sapiens_hsa051441.25998856
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.25109563
27Collecting duct acid secretion_Homo sapiens_hsa049661.22019810
28Dopaminergic synapse_Homo sapiens_hsa047281.20934526
29Long-term depression_Homo sapiens_hsa047301.20216304
30Taste transduction_Homo sapiens_hsa047421.17492186
31Axon guidance_Homo sapiens_hsa043601.16331314
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.15136506
33Serotonergic synapse_Homo sapiens_hsa047261.14645419
34Hepatitis C_Homo sapiens_hsa051601.14506795
35ErbB signaling pathway_Homo sapiens_hsa040121.12085578
36Olfactory transduction_Homo sapiens_hsa047401.10239490
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.08644800
38Type II diabetes mellitus_Homo sapiens_hsa049301.07571350
39Salivary secretion_Homo sapiens_hsa049701.07313160
40Amphetamine addiction_Homo sapiens_hsa050311.07198905
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07043937
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06531270
43Leishmaniasis_Homo sapiens_hsa051401.04911759
44Acute myeloid leukemia_Homo sapiens_hsa052211.04907034
45Dorso-ventral axis formation_Homo sapiens_hsa043201.04489068
46GnRH signaling pathway_Homo sapiens_hsa049121.04311323
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03722286
48GABAergic synapse_Homo sapiens_hsa047271.03682388
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02288091
50Asthma_Homo sapiens_hsa053101.02190257
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01961469
52Notch signaling pathway_Homo sapiens_hsa043301.01022152
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00958228
54Prolactin signaling pathway_Homo sapiens_hsa049171.00584262
55Shigellosis_Homo sapiens_hsa051311.00155389
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.99715520
57Endometrial cancer_Homo sapiens_hsa052130.99559661
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99291156
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.98944401
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98896261
61Colorectal cancer_Homo sapiens_hsa052100.98530270
62Oxytocin signaling pathway_Homo sapiens_hsa049210.97027448
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97003785
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96826017
65Glioma_Homo sapiens_hsa052140.95984082
66Rheumatoid arthritis_Homo sapiens_hsa053230.95575771
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95122080
68Chemokine signaling pathway_Homo sapiens_hsa040620.94335885
69Estrogen signaling pathway_Homo sapiens_hsa049150.94072310
70Renin secretion_Homo sapiens_hsa049240.93524883
71Inositol phosphate metabolism_Homo sapiens_hsa005620.92842130
72MAPK signaling pathway_Homo sapiens_hsa040100.90479109
73Chronic myeloid leukemia_Homo sapiens_hsa052200.89889219
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89377128
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89175459
76Graft-versus-host disease_Homo sapiens_hsa053320.89004355
77Apoptosis_Homo sapiens_hsa042100.88806025
78Lysosome_Homo sapiens_hsa041420.88764593
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88268241
80Platelet activation_Homo sapiens_hsa046110.88137190
81Allograft rejection_Homo sapiens_hsa053300.87829748
82Endocytosis_Homo sapiens_hsa041440.87388003
83TNF signaling pathway_Homo sapiens_hsa046680.86733737
84VEGF signaling pathway_Homo sapiens_hsa043700.86123277
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.86009965
86Pertussis_Homo sapiens_hsa051330.85491859
87Tuberculosis_Homo sapiens_hsa051520.84313167
88Insulin secretion_Homo sapiens_hsa049110.83750822
89African trypanosomiasis_Homo sapiens_hsa051430.83701501
90Toxoplasmosis_Homo sapiens_hsa051450.83608042
91Gap junction_Homo sapiens_hsa045400.83469501
92Measles_Homo sapiens_hsa051620.83345634
93Non-small cell lung cancer_Homo sapiens_hsa052230.82647203
94Calcium signaling pathway_Homo sapiens_hsa040200.81166688
95Legionellosis_Homo sapiens_hsa051340.80304049
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.80292595
97Pancreatic cancer_Homo sapiens_hsa052120.79946445
98mTOR signaling pathway_Homo sapiens_hsa041500.79334138
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78766527
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78615646
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78189489
102Viral myocarditis_Homo sapiens_hsa054160.76836825
103Gastric acid secretion_Homo sapiens_hsa049710.76349233
104Hematopoietic cell lineage_Homo sapiens_hsa046400.75952308
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.75678455
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75041177
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.74639079
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74618336
109FoxO signaling pathway_Homo sapiens_hsa040680.74586373
110Amoebiasis_Homo sapiens_hsa051460.74467994
111Choline metabolism in cancer_Homo sapiens_hsa052310.74011048
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73006456
113HTLV-I infection_Homo sapiens_hsa051660.71852616
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71535453
115Renal cell carcinoma_Homo sapiens_hsa052110.71080851
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70940807
117Vibrio cholerae infection_Homo sapiens_hsa051100.70201042
118Epstein-Barr virus infection_Homo sapiens_hsa051690.69963769
119Viral carcinogenesis_Homo sapiens_hsa052030.69873724
120Ras signaling pathway_Homo sapiens_hsa040140.69022058
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68872220
122Rap1 signaling pathway_Homo sapiens_hsa040150.68584180
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67933668
124Melanogenesis_Homo sapiens_hsa049160.67527415
125Hepatitis B_Homo sapiens_hsa051610.67487277
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67095822
127Salmonella infection_Homo sapiens_hsa051320.66395675
128cAMP signaling pathway_Homo sapiens_hsa040240.66158484
129Phagosome_Homo sapiens_hsa041450.65047610
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64227657
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62311044
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58743578
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57659981
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57416317
135Insulin resistance_Homo sapiens_hsa049310.56577128
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.55693499
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54189908
138Prostate cancer_Homo sapiens_hsa052150.53745515
139HIF-1 signaling pathway_Homo sapiens_hsa040660.51719217
140Focal adhesion_Homo sapiens_hsa045100.51074055
141Bladder cancer_Homo sapiens_hsa052190.50459200
142Proteoglycans in cancer_Homo sapiens_hsa052050.49412582

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