FCMR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.57994303
2antigen processing and presentation of endogenous antigen (GO:0019883)8.54963251
3cellular response to zinc ion (GO:0071294)7.46115039
4regulation of B cell receptor signaling pathway (GO:0050855)6.97559859
5positive regulation of gamma-delta T cell activation (GO:0046645)6.64170834
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.21131550
7regulation of B cell differentiation (GO:0045577)6.16823169
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.92054839
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.92054839
10positive thymic T cell selection (GO:0045059)5.68640968
11mature B cell differentiation (GO:0002335)5.45250852
12B cell proliferation (GO:0042100)5.32781494
13regulation of gamma-delta T cell differentiation (GO:0045586)5.22800606
14positive regulation of B cell differentiation (GO:0045579)5.15138737
15regulation of interferon-beta biosynthetic process (GO:0045357)5.10992153
16regulation of gamma-delta T cell activation (GO:0046643)4.75420248
17regulation of B cell proliferation (GO:0030888)4.73421276
18cellular response to interleukin-15 (GO:0071350)4.72729791
19negative regulation of B cell proliferation (GO:0030889)4.72552395
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.66752905
21response to interleukin-15 (GO:0070672)4.62550843
22antigen receptor-mediated signaling pathway (GO:0050851)4.49753140
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.43452510
24T cell migration (GO:0072678)4.37734378
25regulation of B cell apoptotic process (GO:0002902)4.36498183
26thymic T cell selection (GO:0045061)4.28269117
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.22327708
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.21170068
29positive regulation of Rap GTPase activity (GO:0032854)4.17107746
30positive regulation by symbiont of host defense response (GO:0052509)4.14316221
31modulation by symbiont of host defense response (GO:0052031)4.14316221
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14316221
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14316221
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.14316221
35modulation by symbiont of host immune response (GO:0052553)4.14316221
36lymph node development (GO:0048535)4.13274855
37negative thymic T cell selection (GO:0045060)4.08763754
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.08201984
39negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.06086305
40positive T cell selection (GO:0043368)4.04569348
41immune response-activating cell surface receptor signaling pathway (GO:0002429)4.02881516
42detection of bacterium (GO:0016045)3.99973700
43mature B cell differentiation involved in immune response (GO:0002313)3.99274936
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.98969631
45defense response to protozoan (GO:0042832)3.98388161
46positive regulation of B cell proliferation (GO:0030890)3.97695824
47NIK/NF-kappaB signaling (GO:0038061)3.95029533
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.94331653
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.92789283
50T cell selection (GO:0045058)3.92207682
51negative regulation of B cell apoptotic process (GO:0002903)3.91737590
52regulation of alpha-beta T cell proliferation (GO:0046640)3.89564335
53B cell activation (GO:0042113)3.86443879
54detection of other organism (GO:0098543)3.83742951
55germinal center formation (GO:0002467)3.83452559
56B cell homeostasis (GO:0001782)3.82954469
57regulation of T cell tolerance induction (GO:0002664)3.78106264
58regulation of antigen processing and presentation (GO:0002577)3.76822774
59negative T cell selection (GO:0043383)3.75479965
60positive regulation of humoral immune response (GO:0002922)3.72017380
61cellular response to type I interferon (GO:0071357)3.70290979
62type I interferon signaling pathway (GO:0060337)3.70290979
63negative regulation of T cell mediated immunity (GO:0002710)3.69205326
64negative regulation of histone methylation (GO:0031061)3.68302211
65response to type I interferon (GO:0034340)3.67916524
66negative regulation of phagocytosis (GO:0050765)3.66950172
67immunoglobulin mediated immune response (GO:0016064)3.64092582
68positive regulation of interferon-alpha production (GO:0032727)3.63887630
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.59765024
70regulation of natural killer cell mediated immunity (GO:0002715)3.59765024
71regulation of regulatory T cell differentiation (GO:0045589)3.58188991
72lymphocyte homeostasis (GO:0002260)3.56549278
73T cell receptor signaling pathway (GO:0050852)3.55291049
74positive regulation of granulocyte differentiation (GO:0030854)3.54729457
75regulation of superoxide anion generation (GO:0032928)3.49880443
76regulation of interferon-alpha production (GO:0032647)3.48843970
77regulation of B cell activation (GO:0050864)3.47576299
78positive regulation of B cell activation (GO:0050871)3.47429208
79positive regulation of interleukin-2 production (GO:0032743)3.46924219
80B cell mediated immunity (GO:0019724)3.46780122
81regulation of T cell mediated cytotoxicity (GO:0001914)3.46736433
82regulation of Rap GTPase activity (GO:0032317)3.46680230
83interferon-gamma-mediated signaling pathway (GO:0060333)3.44819698
84negative regulation of leukocyte mediated immunity (GO:0002704)3.44131388
85positive regulation of antigen processing and presentation (GO:0002579)3.43527692
86Fc-gamma receptor signaling pathway (GO:0038094)3.41739646
87Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.41739646
88immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.41739646
89macrophage activation involved in immune response (GO:0002281)3.41445546
90T cell costimulation (GO:0031295)3.40325733
91positive regulation of immunoglobulin production (GO:0002639)3.40227007
92Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.36189661
93positive regulation of histone deacetylation (GO:0031065)3.35795586
94antigen processing and presentation via MHC class Ib (GO:0002475)3.35019910
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33997000
96complement activation, classical pathway (GO:0006958)3.33663538
97positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32976665
98respiratory burst (GO:0045730)3.32266625
99lymphocyte costimulation (GO:0031294)3.32196099
100response to protozoan (GO:0001562)3.32088291
101cytidine metabolic process (GO:0046087)3.29590871
102cytidine catabolic process (GO:0006216)3.29590871
103cytidine deamination (GO:0009972)3.29590871
104positive regulation of alpha-beta T cell proliferation (GO:0046641)3.27362940
105regulation of interleukin-2 biosynthetic process (GO:0045076)3.26027908
106T cell homeostasis (GO:0043029)3.25179933
107regulation of tolerance induction (GO:0002643)3.23725420
108negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23040761
109negative regulation of humoral immune response (GO:0002921)3.22807055
110mononuclear cell proliferation (GO:0032943)3.21487316
111CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.21439264
112lymphocyte proliferation (GO:0046651)3.21256259
113negative regulation of bone resorption (GO:0045779)3.16281492
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15516570
115activated T cell proliferation (GO:0050798)3.15419852
116mast cell activation (GO:0045576)3.14681291
117regulation of isotype switching to IgG isotypes (GO:0048302)3.14407634
118negative regulation of T-helper cell differentiation (GO:0045623)3.14209021
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14209021
120neutrophil activation involved in immune response (GO:0002283)3.13715699
121production of molecular mediator involved in inflammatory response (GO:0002532)3.13550105
122interferon-gamma production (GO:0032609)3.12883489
123tolerance induction (GO:0002507)3.09771337
124regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07658079
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06805909
126leukocyte homeostasis (GO:0001776)3.05302914
127regulation of interferon-gamma biosynthetic process (GO:0045072)3.04370534
128regulation of cell killing (GO:0031341)3.02103518
129B cell differentiation (GO:0030183)3.00908996
130immune response-activating signal transduction (GO:0002757)2.99718290
131regulation of MHC class I biosynthetic process (GO:0045343)2.99349580
132positive regulation of cell killing (GO:0031343)2.98099464
133positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.98050395
134regulation of alpha-beta T cell activation (GO:0046634)2.96989950
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96764913
136humoral immune response (GO:0006959)2.95761211
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94872888
138regulation of T cell receptor signaling pathway (GO:0050856)2.94039614
139activation of JUN kinase activity (GO:0007257)2.93934758
140chaperone mediated protein folding requiring cofactor (GO:0051085)2.93123498
141positive regulation of immunoglobulin mediated immune response (GO:0002891)2.92992549
142positive regulation of B cell mediated immunity (GO:0002714)2.92992549
143I-kappaB phosphorylation (GO:0007252)2.92593730
144neutrophil activation (GO:0042119)2.91834150
145positive regulation of cytokine biosynthetic process (GO:0042108)2.91542366
146negative regulation of alpha-beta T cell activation (GO:0046636)2.89282971
147positive regulation of interleukin-12 production (GO:0032735)2.87950641
148viral transcription (GO:0019083)2.86577904
149leukocyte proliferation (GO:0070661)2.86351982
150leukocyte aggregation (GO:0070486)2.85489308
151B cell activation involved in immune response (GO:0002312)2.84178563
152negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83526015
153negative regulation of cell killing (GO:0031342)2.83526015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.23286362
2MYC_22102868_ChIP-Seq_BL_Human5.15991638
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.10412855
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.63176782
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.18680436
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.85069509
7VDR_21846776_ChIP-Seq_THP-1_Human3.52750266
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50111873
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.22612871
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11980944
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.01735590
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.97891484
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.90561355
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.83373907
15RUNX_20019798_ChIP-Seq_JUKART_Human2.80599994
16MAF_26560356_Chip-Seq_TH1_Human2.69167269
17MYB_26560356_Chip-Seq_TH1_Human2.59079358
18MYB_26560356_Chip-Seq_TH2_Human2.56816903
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44413335
20UTX_26944678_Chip-Seq_JUKART_Human2.41096474
21VDR_24763502_ChIP-Seq_THP-1_Human2.31216202
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21886314
23TCF7_22412390_ChIP-Seq_EML_Mouse2.20146953
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17905731
25CIITA_25753668_ChIP-Seq_RAJI_Human2.17536816
26E2F7_22180533_ChIP-Seq_HELA_Human2.15125298
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14312134
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10554420
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10215420
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04776638
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03504446
32KDM2B_26808549_Chip-Seq_DND41_Human2.00956605
33SPI1_23547873_ChIP-Seq_NB4_Human2.00219038
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94967070
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93373561
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92609928
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.88588678
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86409072
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84466946
40SCL_19346495_ChIP-Seq_HPC-7_Human1.80766304
41MAF_26560356_Chip-Seq_TH2_Human1.80147799
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.74949088
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66139889
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66113450
45SPI1_23127762_ChIP-Seq_K562_Human1.64964514
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56151911
47GATA3_27048872_Chip-Seq_THYMUS_Human1.54689682
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.54321211
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53126594
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51139516
51GATA1_22025678_ChIP-Seq_K562_Human1.48975507
52PU.1_20513432_ChIP-Seq_Bcells_Mouse1.48475369
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46354321
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45258182
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39566203
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38215440
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34340894
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34035792
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32138600
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24989438
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23899984
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23470829
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.23273226
64VDR_24787735_ChIP-Seq_THP-1_Human1.20910629
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20700528
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19273308
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.13105922
68PU_27001747_Chip-Seq_BMDM_Mouse1.12183219
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11954390
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10166094
71LXR_22292898_ChIP-Seq_THP-1_Human1.09531014
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06837929
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06236914
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.03850931
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00348755
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00082575
77NCOR1_26117541_ChIP-Seq_K562_Human0.99984516
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99878747
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99063995
80GATA3_26560356_Chip-Seq_TH2_Human0.98721134
81ELF1_20517297_ChIP-Seq_JURKAT_Human0.96991634
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96810738
83P300_27268052_Chip-Seq_Bcells_Human0.95754424
84GATA1_19941826_ChIP-Seq_K562_Human0.95385780
85KDM5A_27292631_Chip-Seq_BREAST_Human0.93572141
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92960310
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92212988
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.91357931
89BCL6_27268052_Chip-Seq_Bcells_Human0.90366214
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90086497
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.89529719
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89077595
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88844822
94FOXP3_21729870_ChIP-Seq_TREG_Human0.88246517
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86655133
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86145509
97SMRT_27268052_Chip-Seq_Bcells_Human0.85074437
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84947513
99BCOR_27268052_Chip-Seq_Bcells_Human0.84825495
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83912284
101CTCF_26484167_Chip-Seq_Bcells_Mouse0.83261131
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83121545
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82452948
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81670567
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81412626
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79412998
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79247292
108RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79243153
109ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79239118
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77603128
111GATA3_26560356_Chip-Seq_TH1_Human0.75052635
112SPI1_20517297_ChIP-Seq_HL60_Human0.74449510
113VDR_23849224_ChIP-Seq_CD4+_Human0.74354066
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70915436
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.69805378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.98156279
2MP0001790_abnormal_immune_system5.51067657
3MP0005387_immune_system_phenotype5.51067657
4MP0001800_abnormal_humoral_immune5.24424300
5MP0003303_peritoneal_inflammation3.97162974
6MP0002452_abnormal_antigen_presenting3.90662630
7MP0000685_abnormal_immune_system3.77622455
8MP0005000_abnormal_immune_tolerance3.41922072
9MP0002723_abnormal_immune_serum3.23936419
10MP0002420_abnormal_adaptive_immunity3.16546507
11MP0003724_increased_susceptibility_to3.12953807
12MP0001819_abnormal_immune_cell3.05991335
13MP0005671_abnormal_response_to3.04751262
14MP0002398_abnormal_bone_marrow2.91360691
15MP0000716_abnormal_immune_system2.73272030
16MP0000689_abnormal_spleen_morphology2.63575924
17MP0003763_abnormal_thymus_physiology2.46634566
18MP0004510_myositis2.42444095
19MP0002429_abnormal_blood_cell2.22062134
20MP0003300_gastrointestinal_ulcer2.17429303
21MP0002722_abnormal_immune_system2.14829143
22MP0005025_abnormal_response_to2.09608741
23MP0001873_stomach_inflammation2.06994047
24MP0002419_abnormal_innate_immunity1.99110498
25MP0002148_abnormal_hypersensitivity_rea1.92508887
26MP0002166_altered_tumor_susceptibility1.85028482
27MP0004381_abnormal_hair_follicle1.84758784
28MP0002405_respiratory_system_inflammati1.78754897
29MP0001853_heart_inflammation1.74830412
30MP0001845_abnormal_inflammatory_respons1.74575722
31MP0003436_decreased_susceptibility_to1.68331892
32MP0009785_altered_susceptibility_to1.66760940
33MP0003183_abnormal_peptide_metabolism1.63697474
34MP0005075_abnormal_melanosome_morpholog1.58342980
35MP0002396_abnormal_hematopoietic_system1.57841001
36MP0010155_abnormal_intestine_physiology1.55634781
37MP0000703_abnormal_thymus_morphology1.45663456
38MP0005310_abnormal_salivary_gland1.45488374
39MP0004808_abnormal_hematopoietic_stem1.41586079
40MP0004947_skin_inflammation1.38779443
41MP0002009_preneoplasia1.36330705
42MP0003866_abnormal_defecation1.35209854
43MP0002933_joint_inflammation1.32896120
44MP0009333_abnormal_splenocyte_physiolog1.32638615
45MP0000465_gastrointestinal_hemorrhage1.32617736
46MP0008057_abnormal_DNA_replication1.26757557
47MP0001348_abnormal_lacrimal_gland1.24719476
48MP0010234_abnormal_vibrissa_follicle1.23637344
49MP0005464_abnormal_platelet_physiology1.23358960
50MP0002006_tumorigenesis1.17559390
51MP0002136_abnormal_kidney_physiology1.08307932
52MP0003091_abnormal_cell_migration1.08301082
53MP0002909_abnormal_adrenal_gland1.07307203
54MP0002132_abnormal_respiratory_system1.04615455
55MP0010352_gastrointestinal_tract_polyps1.03884646
56MP0000858_altered_metastatic_potential1.02579700
57MP0001851_eye_inflammation1.01136467
58MP0008961_abnormal_basal_metabolism0.98633786
59MP0008469_abnormal_protein_level0.94043631
60MP0002138_abnormal_hepatobiliary_system0.92837997
61MP0005174_abnormal_tail_pigmentation0.91676114
62MP0002019_abnormal_tumor_incidence0.91589199
63MP0001879_abnormal_lymphatic_vessel0.90536114
64MP0003045_fibrosis0.89613992
65MP0002998_abnormal_bone_remodeling0.88693814
66MP0003077_abnormal_cell_cycle0.81793581
67MP0003191_abnormal_cellular_cholesterol0.78546095
68MP0000569_abnormal_digit_pigmentation0.77265440
69MP0002277_abnormal_respiratory_mucosa0.76995010
70MP0003787_abnormal_imprinting0.75340986
71MP0008874_decreased_physiological_sensi0.73323707
72MP0004883_abnormal_blood_vessel0.73000052
73MP0002928_abnormal_bile_duct0.72539750
74MP0005076_abnormal_cell_differentiation0.68670155
75MP0000767_abnormal_smooth_muscle0.67890888
76MP0003566_abnormal_cell_adhesion0.66988698
77MP0006054_spinal_hemorrhage0.66498865
78MP0009763_increased_sensitivity_to0.65231374
79MP0002168_other_aberrant_phenotype0.64583766
80MP0001986_abnormal_taste_sensitivity0.63062920
81MP0001663_abnormal_digestive_system0.61234290
82MP0002163_abnormal_gland_morphology0.58867360
83MP0000490_abnormal_crypts_of0.58423020
84MP0000249_abnormal_blood_vessel0.58154651
85MP0005621_abnormal_cell_physiology0.57329859
86MP0008260_abnormal_autophagy0.56802719
87MP0000350_abnormal_cell_proliferation0.53727563
88MP0006082_CNS_inflammation0.53549896
89MP0005390_skeleton_phenotype0.53231988
90MP0005381_digestive/alimentary_phenotyp0.52391167
91MP0001545_abnormal_hematopoietic_system0.51269451
92MP0005397_hematopoietic_system_phenotyp0.51269451
93MP0005584_abnormal_enzyme/coenzyme_acti0.51046096
94MP0002095_abnormal_skin_pigmentation0.50412708
95MP0005645_abnormal_hypothalamus_physiol0.50172287
96MP0003690_abnormal_glial_cell0.48928575
97MP0005451_abnormal_body_composition0.48503075
98MP0001533_abnormal_skeleton_physiology0.48396402
99MP0000015_abnormal_ear_pigmentation0.47915224
100MP0003279_aneurysm0.47624378
101MP0003075_altered_response_to0.47072988
102MP0000609_abnormal_liver_physiology0.46624742
103MP0009278_abnormal_bone_marrow0.46398960
104MP0003453_abnormal_keratinocyte_physiol0.46109754
105MP0003795_abnormal_bone_structure0.46044709
106MP0000604_amyloidosis0.44680851
107MP0003172_abnormal_lysosome_physiology0.44582177
108MP0009840_abnormal_foam_cell0.44363394
109MP0005058_abnormal_lysosome_morphology0.44129322
110MP0003252_abnormal_bile_duct0.44100351
111MP0004130_abnormal_muscle_cell0.43654241
112MP0003828_pulmonary_edema0.42969781
113MP0005023_abnormal_wound_healing0.42488676
114MP0000733_abnormal_muscle_development0.41809305
115MP0002693_abnormal_pancreas_physiology0.41508913
116MP0005166_decreased_susceptibility_to0.40972392
117MP0009764_decreased_sensitivity_to0.40934414
118MP0000313_abnormal_cell_death0.40321131
119MP0009115_abnormal_fat_cell0.40246237
120MP0002135_abnormal_kidney_morphology0.40239248
121MP0002083_premature_death0.40172403
122MP0002254_reproductive_system_inflammat0.39964120
123MP0009765_abnormal_xenobiotic_induced0.39625959
124MP0010094_abnormal_chromosome_stability0.39305159
125MP0001730_embryonic_growth_arrest0.38726868
126MP0001784_abnormal_fluid_regulation0.38389113
127MP0009643_abnormal_urine_homeostasis0.38336195
128MP0000371_diluted_coat_color0.37822586
129MP0000477_abnormal_intestine_morphology0.37527396
130MP0003448_altered_tumor_morphology0.37025552

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.74883887
2Gastrointestinal stroma tumor (HP:0100723)8.04765936
3Recurrent bronchitis (HP:0002837)6.94961611
4Colitis (HP:0002583)6.41327876
5Recurrent sinusitis (HP:0011108)6.40814925
6Cellulitis (HP:0100658)6.10138597
7IgM deficiency (HP:0002850)5.58643139
8Papilloma (HP:0012740)5.50403404
9Verrucae (HP:0200043)5.50403404
10Inflammation of the large intestine (HP:0002037)5.44731605
11Gastrointestinal inflammation (HP:0004386)5.24557999
12Emphysema (HP:0002097)5.12180423
13Abnormal delayed hypersensitivity skin test (HP:0002963)5.05581459
14Lymphopenia (HP:0001888)5.01784228
15Abnormality of cells of the lymphoid lineage (HP:0012140)4.76704866
16Chronic sinusitis (HP:0011109)4.75839323
17Recurrent viral infections (HP:0004429)4.70258071
18Panhypogammaglobulinemia (HP:0003139)4.66193603
19Elevated erythrocyte sedimentation rate (HP:0003565)4.51242768
20Meningitis (HP:0001287)4.50514402
21Chronic otitis media (HP:0000389)4.38730904
22Abnormality of macrophages (HP:0004311)4.38581671
23Myositis (HP:0100614)4.28260807
24Stomatitis (HP:0010280)4.15430168
25Small epiphyses (HP:0010585)4.04642121
26Vasculitis (HP:0002633)4.02813273
27Bronchitis (HP:0012387)4.01872008
28Restrictive lung disease (HP:0002091)3.91206892
29Recurrent otitis media (HP:0000403)3.81616738
30IgA deficiency (HP:0002720)3.76402512
31Osteomyelitis (HP:0002754)3.68956788
32Recurrent lower respiratory tract infections (HP:0002783)3.68491389
33Recurrent cutaneous fungal infections (HP:0011370)3.60349832
34Chronic mucocutaneous candidiasis (HP:0002728)3.60349832
35Recurrent pneumonia (HP:0006532)3.59235606
36Retrobulbar optic neuritis (HP:0100654)3.58631857
37Optic neuritis (HP:0100653)3.58631857
38Gastrointestinal infarctions (HP:0005244)3.58462341
39Mitral stenosis (HP:0001718)3.57260154
40Recurrent abscess formation (HP:0002722)3.56754067
41Orchitis (HP:0100796)3.52137337
42Recurrent bacterial skin infections (HP:0005406)3.48673844
43Recurrent fungal infections (HP:0002841)3.36236162
44Severe combined immunodeficiency (HP:0004430)3.32915931
45Viral hepatitis (HP:0006562)3.20110713
46Mediastinal lymphadenopathy (HP:0100721)3.19561520
47Sepsis (HP:0100806)3.08242738
48Increased IgM level (HP:0003496)3.05540808
49Abnormality of the fingertips (HP:0001211)3.03034709
50Recurrent skin infections (HP:0001581)3.02513346
51Vertebral arch anomaly (HP:0008438)2.88012158
52Autoimmune hemolytic anemia (HP:0001890)2.87219698
53Urticaria (HP:0001025)2.84255735
54Abnormality of T cell physiology (HP:0011840)2.79490161
55IgG deficiency (HP:0004315)2.77487939
56Granulocytopenia (HP:0001913)2.76977229
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76083022
58Abnormality of B cell number (HP:0010975)2.75517149
59B lymphocytopenia (HP:0010976)2.75517149
60Leukocytosis (HP:0001974)2.75479466
61Eczematoid dermatitis (HP:0000976)2.72214647
62Combined immunodeficiency (HP:0005387)2.71907339
63Abnormality of T cells (HP:0002843)2.71824278
64Leukopenia (HP:0001882)2.70437314
65Nasal polyposis (HP:0100582)2.69409621
66Prolonged bleeding time (HP:0003010)2.64865210
67Chronic diarrhea (HP:0002028)2.64754479
68Thyroiditis (HP:0100646)2.63031478
69Flattened epiphyses (HP:0003071)2.62867374
70Lymphoma (HP:0002665)2.62120518
71Autoimmune thrombocytopenia (HP:0001973)2.57884250
72Keratoconjunctivitis sicca (HP:0001097)2.57277984
73Interstitial pulmonary disease (HP:0006530)2.57034180
74Abnormality of eosinophils (HP:0001879)2.56357813
75Hemoptysis (HP:0002105)2.54079990
76Abnormality of the prostate (HP:0008775)2.51134099
77Eosinophilia (HP:0001880)2.49743678
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46913815
79Gingivitis (HP:0000230)2.46459520
80Keratoconjunctivitis (HP:0001096)2.43791945
81T lymphocytopenia (HP:0005403)2.43431458
82Pustule (HP:0200039)2.43064027
83Hypergammaglobulinemia (HP:0010702)2.36882400
84Abnormality of T cell number (HP:0011839)2.36735237
85Encephalitis (HP:0002383)2.35865141
86Epistaxis (HP:0000421)2.34927138
87Thrombocytosis (HP:0001894)2.32114984
88Irregular vertebral endplates (HP:0003301)2.31607349
89Skin ulcer (HP:0200042)2.28417610
90Pulmonary embolism (HP:0002204)2.27996427
91Spontaneous hematomas (HP:0007420)2.26960842
92Skin rash (HP:0000988)2.25423241
93Pulmonary infiltrates (HP:0002113)2.25143844
94Abnormality of the pleura (HP:0002103)2.24747195
95Chronic obstructive pulmonary disease (HP:0006510)2.24414620
96Obstructive lung disease (HP:0006536)2.24414620
97Ulnar bowing (HP:0003031)2.23653231
98Abnormality of the nasal mucosa (HP:0000433)2.23108473
99Increased IgE level (HP:0003212)2.21791406
100Hypoplasia of the thymus (HP:0000778)2.13028732
101Fatigue (HP:0012378)2.10128081
102Villous atrophy (HP:0011473)2.09755718
103Abnormality of small intestinal villus morphology (HP:0011472)2.09755718
104Joint swelling (HP:0001386)2.09476107
105Gingival bleeding (HP:0000225)2.09140258
106Papilledema (HP:0001085)2.07850314
107Arthralgia (HP:0002829)2.04387014
108Hematochezia (HP:0002573)2.03476880
109Gangrene (HP:0100758)2.01278954
110Neutropenia (HP:0001875)2.01232013
111Xerostomia (HP:0000217)1.98056083
112Anorexia (HP:0002039)1.97338632
113Premature loss of primary teeth (HP:0006323)1.96837367
114Arthropathy (HP:0003040)1.96779699
115Arterial thrombosis (HP:0004420)1.95583073
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94227524
117Absent epiphyses (HP:0010577)1.94227524
118Hepatitis (HP:0012115)1.93488253
119Recurrent gram-negative bacterial infections (HP:0005420)1.91145828
120Petechiae (HP:0000967)1.89883939
121Basal cell carcinoma (HP:0002671)1.86928272
122Acrocyanosis (HP:0001063)1.86669991
123Chest pain (HP:0100749)1.79679194
124Myocardial infarction (HP:0001658)1.76673044
125Abnormality of the vertebral endplates (HP:0005106)1.71265542
126Hypertensive crisis (HP:0100735)1.68299070
127Periodontitis (HP:0000704)1.67461987
128Abnormality of the intervertebral disk (HP:0005108)1.63397339
129Limited elbow extension (HP:0001377)1.62003011
130Resting tremor (HP:0002322)1.59050144
131Aortic regurgitation (HP:0001659)1.50985867
132Facial diplegia (HP:0001349)1.50891252
133Mucosal telangiectasiae (HP:0100579)1.49201143
134Barrel-shaped chest (HP:0001552)1.48454566
135Hypochromic anemia (HP:0001931)1.48377595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.66855709
2GRK63.94432181
3TXK3.63445168
4BLK3.15797843
5CSF1R2.96764097
6MAP3K102.89828606
7ERN12.88481621
8MAP3K132.79295735
9PRPF4B2.71478888
10SYK2.65462222
11LRRK22.64782163
12RIPK42.59139329
13STK102.52707616
14BTK2.41575195
15MAP3K142.27933011
16TESK22.23770471
17TYK21.93547835
18JAK11.89455984
19SIK21.84354916
20PASK1.80186476
21MST41.77754215
22CDK121.69951861
23GRK11.58639702
24LYN1.52701383
25IRAK31.46619362
26MARK31.39609554
27KIT1.38833108
28CSK1.38627175
29TAOK31.38357076
30HCK1.34719069
31IKBKB1.30449141
32SIK31.28943882
33TBK11.27938379
34TGFBR21.23088407
35JAK31.21633364
36MAP3K111.15642614
37ITK1.15555382
38BMPR21.15358999
39EIF2AK31.11181478
40EEF2K1.10548208
41IRAK41.09385015
42PRKCQ1.08712745
43CAMKK11.03780219
44ZAP701.03473247
45TEC1.01305099
46MAP3K90.98577045
47PRKCH0.97630396
48SIK10.97263031
49LCK0.96840649
50BRD40.96019454
51ALK0.95220848
52FES0.93898490
53CDC42BPA0.93859883
54TRIB30.91784848
55PIM10.91037454
56CLK10.87516787
57PRKD20.87391712
58KDR0.86417780
59MATK0.86301225
60TNK20.82996969
61RPS6KA40.81055502
62IKBKE0.80172484
63FGFR30.79270750
64CHUK0.78436526
65TAOK10.74822463
66FGFR40.73645500
67MAPK110.72726099
68MAP3K10.72156949
69MAP3K30.71058361
70HIPK20.68515136
71PDK10.66142358
72CAMKK20.65210192
73MAP2K20.63154000
74MAPK70.62612913
75SMG10.60979688
76MAPK120.56862346
77MAP2K30.56534136
78ABL10.56307008
79FGR0.53965599
80TAOK20.53167187
81CAMK1G0.52825754
82MAP3K70.52293321
83INSR0.51804893
84MELK0.51040401
85CDK40.50722206
86YES10.50328648
87CDK190.48462442
88PRKD10.46792689
89CAMK1D0.46365871
90FYN0.45984904
91CSNK1A1L0.44944526
92EPHB10.44324366
93KSR20.43844260
94PTK60.41438909
95PKN20.41304072
96CDK90.41192203
97WNK10.39613201
98IRAK10.38814148
99EGFR0.37226525
100SGK30.35783273
101MAPKAPK20.33664367
102PRKCD0.32718408
103JAK20.31318293
104NLK0.31274591
105TLK10.31252472
106NEK20.30830912
107MAP3K80.30601581
108CSNK1G10.30571976
109TTN0.28389910
110RPS6KC10.27929375
111RPS6KL10.27929375
112SCYL20.27217712
113PRKCI0.26712772
114STK240.25093131
115CSNK1G30.24678776
116EPHA30.24558556
117STK110.24217427
118GRK70.23763673
119RPS6KA60.23657565
120MARK20.23640320
121MAP3K50.23180661
122CDK60.21867586
123DYRK1B0.21860344
124IRAK20.21765369
125MAP2K10.21310184
126MAPK40.18644500
127PDPK10.18517498
128CSNK1D0.18306317
129MAPK30.15709766
130STK40.15524542

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046626.66430878
2Primary immunodeficiency_Homo sapiens_hsa053406.33379698
3Graft-versus-host disease_Homo sapiens_hsa053323.67845640
4Autoimmune thyroid disease_Homo sapiens_hsa053203.66477537
5Hematopoietic cell lineage_Homo sapiens_hsa046403.16897794
6NF-kappa B signaling pathway_Homo sapiens_hsa040643.08120424
7Type I diabetes mellitus_Homo sapiens_hsa049402.85811439
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.72048249
9Antigen processing and presentation_Homo sapiens_hsa046122.40103825
10Osteoclast differentiation_Homo sapiens_hsa043802.33739393
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.23183561
12Staphylococcus aureus infection_Homo sapiens_hsa051502.22307356
13T cell receptor signaling pathway_Homo sapiens_hsa046602.11400968
14Leishmaniasis_Homo sapiens_hsa051401.95157557
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85008287
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76383526
17Chemokine signaling pathway_Homo sapiens_hsa040621.68345251
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55726758
19Herpes simplex infection_Homo sapiens_hsa051681.48090151
20Measles_Homo sapiens_hsa051621.45957512
21Tuberculosis_Homo sapiens_hsa051521.45948949
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40811390
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.38146510
24Epstein-Barr virus infection_Homo sapiens_hsa051691.36512280
25Base excision repair_Homo sapiens_hsa034101.31469778
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27089597
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26572624
28Rheumatoid arthritis_Homo sapiens_hsa053231.25158811
29Non-small cell lung cancer_Homo sapiens_hsa052231.22073821
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21717268
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.18927493
32Shigellosis_Homo sapiens_hsa051311.18031476
33Ribosome_Homo sapiens_hsa030101.17030412
34Platelet activation_Homo sapiens_hsa046111.16150035
35Toxoplasmosis_Homo sapiens_hsa051451.14939169
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.13294947
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12974248
38Hepatitis B_Homo sapiens_hsa051611.10431304
39Chronic myeloid leukemia_Homo sapiens_hsa052201.06027864
40Influenza A_Homo sapiens_hsa051641.05691177
41Acute myeloid leukemia_Homo sapiens_hsa052211.04872861
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99058416
43Pancreatic cancer_Homo sapiens_hsa052120.97903584
44Apoptosis_Homo sapiens_hsa042100.96925493
45African trypanosomiasis_Homo sapiens_hsa051430.90976603
46Viral myocarditis_Homo sapiens_hsa054160.88430715
47Mismatch repair_Homo sapiens_hsa034300.87273340
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85331895
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83863900
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83195110
51Phagosome_Homo sapiens_hsa041450.83002427
52Other glycan degradation_Homo sapiens_hsa005110.79370739
53VEGF signaling pathway_Homo sapiens_hsa043700.78660869
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78377810
55HTLV-I infection_Homo sapiens_hsa051660.75704404
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75580543
57MAPK signaling pathway_Homo sapiens_hsa040100.75217929
58Viral carcinogenesis_Homo sapiens_hsa052030.74069845
59Hepatitis C_Homo sapiens_hsa051600.72844690
60Malaria_Homo sapiens_hsa051440.72833509
61TNF signaling pathway_Homo sapiens_hsa046680.70280560
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65799071
63Systemic lupus erythematosus_Homo sapiens_hsa053220.63638773
64Non-homologous end-joining_Homo sapiens_hsa034500.62319812
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60839469
66Lysine degradation_Homo sapiens_hsa003100.60693291
67Dorso-ventral axis formation_Homo sapiens_hsa043200.59846268
68Pertussis_Homo sapiens_hsa051330.58789323
69Insulin resistance_Homo sapiens_hsa049310.57749238
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57377202
71FoxO signaling pathway_Homo sapiens_hsa040680.57153463
72Small cell lung cancer_Homo sapiens_hsa052220.56396241
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54376037
74Endocytosis_Homo sapiens_hsa041440.54321653
75Salmonella infection_Homo sapiens_hsa051320.53917990
76Renal cell carcinoma_Homo sapiens_hsa052110.53878882
77Notch signaling pathway_Homo sapiens_hsa043300.52317114
78mTOR signaling pathway_Homo sapiens_hsa041500.50890975
79MicroRNAs in cancer_Homo sapiens_hsa052060.48638557
80Inositol phosphate metabolism_Homo sapiens_hsa005620.48352089
81Proteoglycans in cancer_Homo sapiens_hsa052050.47225457
82DNA replication_Homo sapiens_hsa030300.47132737
83Colorectal cancer_Homo sapiens_hsa052100.45850974
84Endometrial cancer_Homo sapiens_hsa052130.45251091
85Glioma_Homo sapiens_hsa052140.44746210
86Prolactin signaling pathway_Homo sapiens_hsa049170.44282291
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.44034925
88Spliceosome_Homo sapiens_hsa030400.43289199
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40558730
90Legionellosis_Homo sapiens_hsa051340.38730271
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38239254
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.36294683
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36196125
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35924924
95Prostate cancer_Homo sapiens_hsa052150.35533658
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.33764739
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33248959
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32139297
99Asthma_Homo sapiens_hsa053100.31204846
100Allograft rejection_Homo sapiens_hsa053300.30241165
101Long-term potentiation_Homo sapiens_hsa047200.29238662
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29174908
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.27710519
104GnRH signaling pathway_Homo sapiens_hsa049120.27414107
105mRNA surveillance pathway_Homo sapiens_hsa030150.25596043
106Choline metabolism in cancer_Homo sapiens_hsa052310.25386050
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.23348029
108Estrogen signaling pathway_Homo sapiens_hsa049150.23223637
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22767298
110Thyroid cancer_Homo sapiens_hsa052160.22486104
111HIF-1 signaling pathway_Homo sapiens_hsa040660.22257185
112Lysosome_Homo sapiens_hsa041420.22208268
113Ras signaling pathway_Homo sapiens_hsa040140.21700220
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21620944
115Pathways in cancer_Homo sapiens_hsa052000.21231303
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20760749
117ErbB signaling pathway_Homo sapiens_hsa040120.20730650
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19928409
119Rap1 signaling pathway_Homo sapiens_hsa040150.19415860
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17888560
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12808779

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