FCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.93570696
2negative regulation of cell killing (GO:0031342)6.41408035
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.41408035
4positive regulation of gamma-delta T cell activation (GO:0046645)6.22780496
5positive regulation by symbiont of host defense response (GO:0052509)5.92218130
6modulation by symbiont of host defense response (GO:0052031)5.92218130
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.92218130
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.92218130
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.92218130
10modulation by symbiont of host immune response (GO:0052553)5.92218130
11neutrophil activation involved in immune response (GO:0002283)5.82754398
12detection of other organism (GO:0098543)5.77937516
13response to peptidoglycan (GO:0032494)5.57558591
14detection of bacterium (GO:0016045)5.55156477
15antigen processing and presentation of endogenous antigen (GO:0019883)5.20844794
16macrophage activation involved in immune response (GO:0002281)5.14263463
17leukocyte aggregation (GO:0070486)5.02377458
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.82847579
19regulation of B cell receptor signaling pathway (GO:0050855)4.73471264
20negative regulation of interleukin-12 production (GO:0032695)4.71452050
21cellular extravasation (GO:0045123)4.70633120
22detection of external biotic stimulus (GO:0098581)4.67723017
23regulation of gamma-delta T cell activation (GO:0046643)4.60043160
24leukocyte migration involved in inflammatory response (GO:0002523)4.49921594
25respiratory burst (GO:0045730)4.33549402
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32829460
27detection of molecule of bacterial origin (GO:0032490)4.31910802
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.27416243
29neutrophil activation (GO:0042119)4.26280131
30microglial cell activation (GO:0001774)4.24011035
31detection of biotic stimulus (GO:0009595)4.23839823
32response to host immune response (GO:0052572)4.17043565
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17043565
34positive regulation of mast cell activation (GO:0033005)4.12922060
35regulation of mast cell degranulation (GO:0043304)4.08643082
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00399368
37regulation of interferon-beta biosynthetic process (GO:0045357)3.98485680
38negative regulation of T cell mediated immunity (GO:0002710)3.98026975
39myeloid cell activation involved in immune response (GO:0002275)3.97417288
40immunoglobulin mediated immune response (GO:0016064)3.94765338
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.94241673
42macrophage activation (GO:0042116)3.90679420
43granulocyte activation (GO:0036230)3.88620739
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84223650
45response to host (GO:0075136)3.84223650
46response to host defenses (GO:0052200)3.84223650
47regulation of mast cell activation involved in immune response (GO:0033006)3.80007537
48regulation of gamma-delta T cell differentiation (GO:0045586)3.79248174
49regulation of myeloid leukocyte mediated immunity (GO:0002886)3.78844271
50negative regulation of leukocyte mediated immunity (GO:0002704)3.77939811
51neutrophil mediated immunity (GO:0002446)3.76643355
52antigen processing and presentation via MHC class Ib (GO:0002475)3.74539486
53regulation of mast cell activation (GO:0033003)3.68592750
54response to muramyl dipeptide (GO:0032495)3.65008806
55regulation of leukocyte degranulation (GO:0043300)3.64867888
56negative regulation of erythrocyte differentiation (GO:0045647)3.61398220
57positive regulation of mast cell degranulation (GO:0043306)3.53789315
58positive regulation of mast cell activation involved in immune response (GO:0033008)3.53789315
59regulation of tolerance induction (GO:0002643)3.51824944
60regulation of T cell tolerance induction (GO:0002664)3.42222181
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.40413749
62leukocyte degranulation (GO:0043299)3.39154663
63activated T cell proliferation (GO:0050798)3.36450538
64regulation of T-helper 2 cell differentiation (GO:0045628)3.34323616
65production of molecular mediator involved in inflammatory response (GO:0002532)3.30538629
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29447600
67B cell receptor signaling pathway (GO:0050853)3.24937263
68myeloid leukocyte mediated immunity (GO:0002444)3.21838148
69type I interferon signaling pathway (GO:0060337)3.21133136
70cellular response to type I interferon (GO:0071357)3.21133136
71response to interleukin-15 (GO:0070672)3.20018660
72regulation of regulated secretory pathway (GO:1903305)3.18648135
73response to type I interferon (GO:0034340)3.18184157
74defense response to protozoan (GO:0042832)3.13255958
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13008063
76regulation of B cell differentiation (GO:0045577)3.12996710
77interferon-gamma-mediated signaling pathway (GO:0060333)3.12111278
78positive regulation of cellular amide metabolic process (GO:0034250)3.10637081
79positive thymic T cell selection (GO:0045059)3.10514515
80positive regulation of B cell differentiation (GO:0045579)3.08722091
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06739829
82regulation of T cell mediated cytotoxicity (GO:0001914)3.06355558
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05483282
84negative thymic T cell selection (GO:0045060)3.03134683
85B cell mediated immunity (GO:0019724)3.02524673
86lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02200280
87negative regulation of interleukin-6 production (GO:0032715)2.98029268
88positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97076453
89myeloid leukocyte activation (GO:0002274)2.96840228
90positive regulation of tolerance induction (GO:0002645)2.96485955
91T cell migration (GO:0072678)2.95496892
92negative T cell selection (GO:0043383)2.93982340
93negative regulation of cytokine production involved in immune response (GO:0002719)2.92631144
94positive regulation of type 2 immune response (GO:0002830)2.92293961
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91684233
96T cell selection (GO:0045058)2.90895284
97cell wall macromolecule catabolic process (GO:0016998)2.89843656
98negative regulation of type 2 immune response (GO:0002829)2.87975865
99neutrophil chemotaxis (GO:0030593)2.86405149
100mast cell activation (GO:0045576)2.82728814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.37310138
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.68842671
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.19208492
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68031335
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64077380
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27953270
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.26659731
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07727932
9RUNX_20019798_ChIP-Seq_JUKART_Human2.86885056
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80574878
11VDR_21846776_ChIP-Seq_THP-1_Human2.73813747
12VDR_24763502_ChIP-Seq_THP-1_Human2.71822529
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70528796
14* SPI1_23547873_ChIP-Seq_NB4_Human2.69942395
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68019012
16SPI1_23127762_ChIP-Seq_K562_Human2.66034151
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52151569
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44003253
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41723103
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34241733
21MAF_26560356_Chip-Seq_TH1_Human2.34239276
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32740015
23SCL_19346495_ChIP-Seq_HPC-7_Human2.30094371
24MYB_26560356_Chip-Seq_TH2_Human2.28409609
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.19627641
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19576707
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16137822
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14293564
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10154890
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08589597
31UTX_26944678_Chip-Seq_JUKART_Human2.07834471
32VDR_24787735_ChIP-Seq_THP-1_Human1.99678419
33MYC_22102868_ChIP-Seq_BL_Human1.97145480
34TCF7_22412390_ChIP-Seq_EML_Mouse1.95129034
35MYB_26560356_Chip-Seq_TH1_Human1.92778535
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91779564
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89545248
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82130530
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.79105927
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77522214
41KDM2B_26808549_Chip-Seq_DND41_Human1.75277523
42MAF_26560356_Chip-Seq_TH2_Human1.71769903
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64543574
44GATA3_27048872_Chip-Seq_THYMUS_Human1.64453635
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63896324
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57150578
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56058754
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54707718
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.52484874
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.51219593
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47223281
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45829309
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45639755
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44059527
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43990158
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43019515
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38123597
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36733132
59PU_27001747_Chip-Seq_BMDM_Mouse1.36177281
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35723124
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34502752
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33294589
63GATA1_19941826_ChIP-Seq_K562_Human1.32575531
64LXR_22292898_ChIP-Seq_THP-1_Human1.32222672
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30825379
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30594796
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29575668
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29337040
69GATA3_26560356_Chip-Seq_TH2_Human1.28771423
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28679701
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27003823
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26144231
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25326358
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21997546
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21673315
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21599448
77BCL6_27268052_Chip-Seq_Bcells_Human1.19809957
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17933408
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17498610
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.17222742
81* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17190538
82BCOR_27268052_Chip-Seq_Bcells_Human1.16615377
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10706613
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06325181
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06014437
86GATA2_19941826_ChIP-Seq_K562_Human0.98205410
87SPI1_20517297_ChIP-Seq_HL60_Human0.93790263
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.93326106
89* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91411757
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90980539
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90779127
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90123811
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.88679033
94NCOR1_26117541_ChIP-Seq_K562_Human0.85479929
95SMRT_27268052_Chip-Seq_Bcells_Human0.84011917
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83652039
97P300_27268052_Chip-Seq_Bcells_Human0.82205478
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82104870
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.81387178
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78304055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.73447194
2MP0003436_decreased_susceptibility_to4.33808925
3MP0001835_abnormal_antigen_presentation3.90116549
4MP0003303_peritoneal_inflammation3.84046494
5MP0002419_abnormal_innate_immunity3.31220437
6MP0006082_CNS_inflammation3.09174749
7MP0009785_altered_susceptibility_to3.06027448
8MP0005025_abnormal_response_to2.98131462
9MP0005671_abnormal_response_to2.89219429
10MP0001800_abnormal_humoral_immune2.86925630
11MP0005000_abnormal_immune_tolerance2.82945563
12MP0000685_abnormal_immune_system2.77309416
13MP0005387_immune_system_phenotype2.74523354
14MP0001790_abnormal_immune_system2.74523354
15MP0002723_abnormal_immune_serum2.58828715
16MP0002452_abnormal_antigen_presenting2.53854393
17MP0002420_abnormal_adaptive_immunity2.52436059
18MP0001819_abnormal_immune_cell2.49512096
19MP0003300_gastrointestinal_ulcer2.34050286
20MP0002148_abnormal_hypersensitivity_rea2.22102412
21MP0001533_abnormal_skeleton_physiology2.21157079
22MP0003828_pulmonary_edema2.17249963
23MP0008260_abnormal_autophagy2.14541884
24MP0003172_abnormal_lysosome_physiology2.12042310
25MP0002132_abnormal_respiratory_system2.05681582
26MP0005464_abnormal_platelet_physiology2.05155365
27MP0003763_abnormal_thymus_physiology2.02966696
28MP0002405_respiratory_system_inflammati1.95111808
29MP0002398_abnormal_bone_marrow1.85981114
30MP0000716_abnormal_immune_system1.84342181
31MP0003191_abnormal_cellular_cholesterol1.83327825
32MP0001845_abnormal_inflammatory_respons1.76659439
33MP0009278_abnormal_bone_marrow1.72156101
34MP0004947_skin_inflammation1.70382945
35MP0010155_abnormal_intestine_physiology1.66463235
36MP0000689_abnormal_spleen_morphology1.57739002
37MP0002722_abnormal_immune_system1.56795362
38MP0004510_myositis1.56368299
39MP0004883_abnormal_blood_vessel1.54793239
40MP0009333_abnormal_splenocyte_physiolog1.50208508
41MP0009764_decreased_sensitivity_to1.49392263
42MP0005310_abnormal_salivary_gland1.48390801
43MP0008469_abnormal_protein_level1.47411243
44MP0002429_abnormal_blood_cell1.44448870
45MP0005058_abnormal_lysosome_morphology1.43259476
46MP0000465_gastrointestinal_hemorrhage1.39845113
47MP0003866_abnormal_defecation1.39011080
48MP0000703_abnormal_thymus_morphology1.38077979
49MP0003690_abnormal_glial_cell1.35314772
50MP0001851_eye_inflammation1.35196774
51MP0002998_abnormal_bone_remodeling1.32139093
52MP0003075_altered_response_to1.32065357
53MP0005451_abnormal_body_composition1.31617960
54MP0000858_altered_metastatic_potential1.30085489
55MP0001545_abnormal_hematopoietic_system1.29232610
56MP0005397_hematopoietic_system_phenotyp1.29232610
57MP0003183_abnormal_peptide_metabolism1.28349059
58MP0004381_abnormal_hair_follicle1.23235519
59MP0005166_decreased_susceptibility_to1.16273547
60MP0002396_abnormal_hematopoietic_system1.14193550
61MP0005164_abnormal_response_to1.13675170
62MP0002166_altered_tumor_susceptibility1.13231843
63MP0005410_abnormal_fertilization1.04685491
64MP0008004_abnormal_stomach_pH0.98807683
65MP0001853_heart_inflammation0.98687595
66MP0002277_abnormal_respiratory_mucosa0.96240427
67MP0003448_altered_tumor_morphology0.92752090
68MP0001986_abnormal_taste_sensitivity0.91498076
69MP0000343_altered_response_to0.89121085
70MP0005390_skeleton_phenotype0.87426438
71MP0005083_abnormal_biliary_tract0.86556947
72MP0003806_abnormal_nucleotide_metabolis0.86184383
73MP0001663_abnormal_digestive_system0.84226249
74MP0009763_increased_sensitivity_to0.81107628
75MP0000604_amyloidosis0.80847182
76MP0003656_abnormal_erythrocyte_physiolo0.80507121
77MP0001873_stomach_inflammation0.79455615
78MP0005377_hearing/vestibular/ear_phenot0.74743612
79MP0003878_abnormal_ear_physiology0.74743612
80MP0005075_abnormal_melanosome_morpholog0.73122123
81MP0002009_preneoplasia0.71814572
82MP0002138_abnormal_hepatobiliary_system0.70607464
83MP0002933_joint_inflammation0.69554217
84MP0004808_abnormal_hematopoietic_stem0.68230339
85MP0002006_tumorigenesis0.67865586
86MP0009765_abnormal_xenobiotic_induced0.66998499
87MP0000015_abnormal_ear_pigmentation0.66413561
88MP0000569_abnormal_digit_pigmentation0.65521543
89MP0000249_abnormal_blood_vessel0.65489749
90MP0003045_fibrosis0.65360602
91MP0008874_decreased_physiological_sensi0.63696570
92MP0003795_abnormal_bone_structure0.62777881
93MP0003091_abnormal_cell_migration0.62442210
94MP0002928_abnormal_bile_duct0.61905037
95MP0004130_abnormal_muscle_cell0.61762840
96MP0000490_abnormal_crypts_of0.58773129
97MP0005076_abnormal_cell_differentiation0.57380396
98MP0003221_abnormal_cardiomyocyte_apopto0.56830445
99MP0002332_abnormal_exercise_endurance0.56437407
100MP0004484_altered_response_of0.55766948

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.06033890
2Recurrent bacterial skin infections (HP:0005406)6.68306628
3Recurrent abscess formation (HP:0002722)6.57254071
4Abnormality of macrophages (HP:0004311)5.99987401
5Myositis (HP:0100614)5.85911311
6Recurrent gram-negative bacterial infections (HP:0005420)5.54081474
7Orchitis (HP:0100796)5.44597088
8Retrobulbar optic neuritis (HP:0100654)5.31263361
9Optic neuritis (HP:0100653)5.31263361
10Stomatitis (HP:0010280)5.03027838
11Elevated erythrocyte sedimentation rate (HP:0003565)4.78389643
12Recurrent skin infections (HP:0001581)4.33304871
13Recurrent fungal infections (HP:0002841)4.32088197
14Gastrointestinal infarctions (HP:0005244)4.28189999
15Obstructive lung disease (HP:0006536)4.22256888
16Chronic obstructive pulmonary disease (HP:0006510)4.22256888
17Mediastinal lymphadenopathy (HP:0100721)4.13745679
18Meningitis (HP:0001287)3.93434868
19Gingivitis (HP:0000230)3.81359608
20Keratoconjunctivitis sicca (HP:0001097)3.79832584
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.74037363
22Chronic mucocutaneous candidiasis (HP:0002728)3.72912638
23Recurrent cutaneous fungal infections (HP:0011370)3.72912638
24Encephalitis (HP:0002383)3.58497931
25Keratoconjunctivitis (HP:0001096)3.50824241
26Urticaria (HP:0001025)3.45197022
27Hypochromic microcytic anemia (HP:0004840)3.42852438
28Prolonged bleeding time (HP:0003010)3.40379813
29Vasculitis (HP:0002633)3.35868485
30Amyloidosis (HP:0011034)3.35152990
31Spontaneous hematomas (HP:0007420)3.32601751
32Episodic fever (HP:0001954)3.25006728
33Increased IgE level (HP:0003212)3.19333086
34Hemoptysis (HP:0002105)3.13870703
35Cellulitis (HP:0100658)3.13543198
36Chest pain (HP:0100749)3.12634101
37Pulmonary infiltrates (HP:0002113)3.02304521
38Hypochromic anemia (HP:0001931)2.97695663
39Leukocytosis (HP:0001974)2.96308645
40Arterial thrombosis (HP:0004420)2.91177080
41Recurrent viral infections (HP:0004429)2.88781247
42Gingival bleeding (HP:0000225)2.88315252
43T lymphocytopenia (HP:0005403)2.86910193
44Peritonitis (HP:0002586)2.80087981
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.77448453
46Abnormality of T cell number (HP:0011839)2.74417366
47Epistaxis (HP:0000421)2.71944962
48Inflammation of the large intestine (HP:0002037)2.69380931
49Anorexia (HP:0002039)2.66974821
50Gastrointestinal inflammation (HP:0004386)2.58267193
51Increased cerebral lipofuscin (HP:0011813)2.57277381
52Pustule (HP:0200039)2.56537863
53Pulmonary embolism (HP:0002204)2.53572050
54Osteomyelitis (HP:0002754)2.53171559
55Panhypogammaglobulinemia (HP:0003139)2.49821766
56Abnormality of T cells (HP:0002843)2.49144268
57Petechiae (HP:0000967)2.46215450
58Colitis (HP:0002583)2.39056585
59Gangrene (HP:0100758)2.30957655
60Granulocytopenia (HP:0001913)2.29146038
61Increased IgM level (HP:0003496)2.27079052
62Abnormality of the pleura (HP:0002103)2.23593530
63Increased serum ferritin (HP:0003281)2.22449709
64Sepsis (HP:0100806)2.21304276
65Vertigo (HP:0002321)2.19784849
66Abnormality of liposaccharide metabolism (HP:0010968)2.17024444
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.17024444
68Abnormality of glycolipid metabolism (HP:0010969)2.17024444
69Abnormality of T cell physiology (HP:0011840)2.16087551
70Microcytic anemia (HP:0001935)2.16056931
71Purpura (HP:0000979)2.14611596
72Loss of speech (HP:0002371)2.13942470
73Lymphopenia (HP:0001888)2.10222452
74Glomerulopathy (HP:0100820)2.08119911
75Recurrent pneumonia (HP:0006532)2.08089061
76Abnormality of the endocardium (HP:0004306)2.07166259
77Abnormality of iron homeostasis (HP:0011031)2.05925908
78Acne (HP:0001061)2.02977150
79Abnormality of the peritoneum (HP:0002585)2.02561227
80Polyneuropathy (HP:0001271)2.02333939
81Skin ulcer (HP:0200042)1.98284312
82Slow saccadic eye movements (HP:0000514)1.98137363
83Hypergammaglobulinemia (HP:0010702)1.96811284
84Abnormality of cells of the lymphoid lineage (HP:0012140)1.96125695
85Malnutrition (HP:0004395)1.95925905
86Abnormal platelet volume (HP:0011876)1.95257783
87Cheilitis (HP:0100825)1.93856533
88Hepatosplenomegaly (HP:0001433)1.92190176
89Amaurosis fugax (HP:0100576)1.91196270
90Acute hepatic failure (HP:0006554)1.90266828
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.89341811
92Keratitis (HP:0000491)1.88851541
93Eosinophilia (HP:0001880)1.88846629
94Autoimmune thrombocytopenia (HP:0001973)1.88776977
95Nasal polyposis (HP:0100582)1.81222681
96Dysostosis multiplex (HP:0000943)1.79389622
97Abnormality of the pericardium (HP:0001697)1.78585867
98Splenomegaly (HP:0001744)1.77603556
99Recurrent lower respiratory tract infections (HP:0002783)1.77546787
100IgM deficiency (HP:0002850)1.76557870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.21211660
2BLK3.48622004
3MAP4K13.30262967
4MAP2K33.04859208
5TYK22.86632801
6IRAK42.85322471
7CSK2.83716117
8PRPF4B2.80838410
9FES2.76237978
10TNK22.33635215
11GRK62.21105314
12ERN12.18812143
13ZAP702.14661094
14FGR2.09169398
15MAP3K32.05685309
16BTK1.84857493
17JAK31.84420545
18SYK1.77625537
19TXK1.70074090
20MAP3K131.68953244
21HCK1.67188989
22TAOK11.67055304
23MAP3K141.60206361
24EPHB11.55862742
25MAP3K111.54629579
26IKBKE1.48548325
27JAK11.36977117
28LYN1.36647207
29KSR21.36449799
30JAK21.36146449
31MAP3K11.29425429
32TBK11.26373631
33CSF1R1.21660815
34LCK1.16631763
35SIK31.16507181
36YES11.14167872
37KIT1.11638003
38TEC1.10077452
39TAOK31.08898542
40PDK11.08253245
41ITK1.06522831
42MARK31.04205246
43MARK21.03623756
44PDPK11.00548885
45BMPR20.98058433
46IKBKB0.93203609
47MATK0.90495575
48STK100.87163074
49IRAK20.85852808
50SIK20.83325670
51MAP3K20.80904298
52IRAK10.80459680
53TAOK20.77814905
54PIK3CG0.76933431
55MAP3K60.75985722
56CDK190.75770456
57PRKD20.73505116
58PTK60.73167001
59MAPK70.71108941
60MAP3K70.69996526
61TRIB30.69881185
62PTK2B0.68946686
63FYN0.67967298
64DYRK1B0.67191257
65STK380.67116755
66MAPK120.66863796
67SGK30.62828168
68TGFBR20.61606791
69CAMKK20.57816207
70TESK20.57640327
71LRRK20.57575786
72MAP2K40.55418225
73RPS6KC10.54892127
74RPS6KL10.54892127
75PRKCQ0.53573410
76STK110.53306886
77CDC42BPA0.49371523
78RPS6KA60.47025119
79FGFR30.46865319
80SGK20.46187929
81GRK70.44995131
82MAP3K50.44866386
83MOS0.42577492
84WNK10.41468282
85HIPK20.39852677
86RET0.37702834
87KSR10.37665180
88RAF10.36237590
89NLK0.35953966
90DAPK20.35605078
91PIM10.35304057
92CAMK40.35240135
93CAMKK10.35138028
94CAMK1D0.32675012
95RPS6KA20.30767467
96MAP2K20.29521618
97MAPKAPK20.28433381
98SMG10.28251106
99MAP3K80.27068279
100FGFR40.26297415

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.07946489
2Leishmaniasis_Homo sapiens_hsa051403.03601265
3Staphylococcus aureus infection_Homo sapiens_hsa051502.70027878
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54988828
5Graft-versus-host disease_Homo sapiens_hsa053322.44997029
6Allograft rejection_Homo sapiens_hsa053302.39940117
7Autoimmune thyroid disease_Homo sapiens_hsa053202.22357532
8B cell receptor signaling pathway_Homo sapiens_hsa046622.21318901
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19038826
10Tuberculosis_Homo sapiens_hsa051522.16842645
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04398764
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00694235
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93584121
14Malaria_Homo sapiens_hsa051441.86518028
15Primary immunodeficiency_Homo sapiens_hsa053401.84310573
16Type I diabetes mellitus_Homo sapiens_hsa049401.82775636
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78849764
18Antigen processing and presentation_Homo sapiens_hsa046121.74080202
19Legionellosis_Homo sapiens_hsa051341.69044949
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64871071
21Chemokine signaling pathway_Homo sapiens_hsa040621.63615736
22Hematopoietic cell lineage_Homo sapiens_hsa046401.63354172
23Acute myeloid leukemia_Homo sapiens_hsa052211.63160011
24Measles_Homo sapiens_hsa051621.62379955
25T cell receptor signaling pathway_Homo sapiens_hsa046601.59091037
26Viral myocarditis_Homo sapiens_hsa054161.58665666
27Influenza A_Homo sapiens_hsa051641.52688996
28Toxoplasmosis_Homo sapiens_hsa051451.51958989
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.47595361
30Other glycan degradation_Homo sapiens_hsa005111.46190088
31Phagosome_Homo sapiens_hsa041451.43968634
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.34007194
33Herpes simplex infection_Homo sapiens_hsa051681.30660748
34Asthma_Homo sapiens_hsa053101.30367974
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.27299424
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26037994
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23254854
38TNF signaling pathway_Homo sapiens_hsa046681.20466766
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.18181907
40Platelet activation_Homo sapiens_hsa046111.18157730
41Non-small cell lung cancer_Homo sapiens_hsa052231.17464238
42African trypanosomiasis_Homo sapiens_hsa051431.17403719
43Pertussis_Homo sapiens_hsa051331.14944710
44Hepatitis B_Homo sapiens_hsa051611.08357631
45Rheumatoid arthritis_Homo sapiens_hsa053231.03341781
46Salmonella infection_Homo sapiens_hsa051320.99454198
47Shigellosis_Homo sapiens_hsa051310.89622219
48VEGF signaling pathway_Homo sapiens_hsa043700.88542314
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88042731
50Hepatitis C_Homo sapiens_hsa051600.87718715
51Lysosome_Homo sapiens_hsa041420.86226472
52Pancreatic cancer_Homo sapiens_hsa052120.84612351
53Chronic myeloid leukemia_Homo sapiens_hsa052200.83514026
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.81034381
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80727868
56Endocytosis_Homo sapiens_hsa041440.80444196
57Apoptosis_Homo sapiens_hsa042100.78988038
58Renal cell carcinoma_Homo sapiens_hsa052110.78376549
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78323914
60Prolactin signaling pathway_Homo sapiens_hsa049170.76621595
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75655045
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75613099
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74796556
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74695180
65Dorso-ventral axis formation_Homo sapiens_hsa043200.74029134
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.72422295
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.72301490
68Type II diabetes mellitus_Homo sapiens_hsa049300.69208079
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.68984930
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67516215
71Amoebiasis_Homo sapiens_hsa051460.66645989
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.65837248
73Notch signaling pathway_Homo sapiens_hsa043300.65688985
74FoxO signaling pathway_Homo sapiens_hsa040680.65633142
75Epstein-Barr virus infection_Homo sapiens_hsa051690.65141635
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64676208
77GnRH signaling pathway_Homo sapiens_hsa049120.64621607
78Choline metabolism in cancer_Homo sapiens_hsa052310.61965869
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59403825
80Endometrial cancer_Homo sapiens_hsa052130.59075067
81HIF-1 signaling pathway_Homo sapiens_hsa040660.58981732
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57300648
83Inositol phosphate metabolism_Homo sapiens_hsa005620.56039344
84Viral carcinogenesis_Homo sapiens_hsa052030.54537490
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51911146
86mTOR signaling pathway_Homo sapiens_hsa041500.51437812
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.50635505
88MAPK signaling pathway_Homo sapiens_hsa040100.50561191
89HTLV-I infection_Homo sapiens_hsa051660.47521837
90Colorectal cancer_Homo sapiens_hsa052100.46856775
91Regulation of autophagy_Homo sapiens_hsa041400.45587431
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45172433
93Insulin resistance_Homo sapiens_hsa049310.44861937
94Estrogen signaling pathway_Homo sapiens_hsa049150.44564119
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43454999
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41889264
97Rap1 signaling pathway_Homo sapiens_hsa040150.39606739
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35682573
99ErbB signaling pathway_Homo sapiens_hsa040120.35538863
100Long-term potentiation_Homo sapiens_hsa047200.32609988

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