FCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.99214280
2drug catabolic process (GO:0042737)9.56857134
3regulation of protein activation cascade (GO:2000257)8.57948935
4regulation of complement activation (GO:0030449)8.23630553
5regulation of fibrinolysis (GO:0051917)7.77782544
6glyoxylate metabolic process (GO:0046487)7.64425261
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54279917
8L-phenylalanine catabolic process (GO:0006559)7.54279917
9ethanol oxidation (GO:0006069)7.53409491
10negative regulation of fibrinolysis (GO:0051918)7.16935172
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.87642834
12L-phenylalanine metabolic process (GO:0006558)6.87642834
13drug metabolic process (GO:0017144)6.49038304
14urea metabolic process (GO:0019627)6.42978453
15protein carboxylation (GO:0018214)6.32798261
16peptidyl-glutamic acid carboxylation (GO:0017187)6.32798261
17imidazole-containing compound metabolic process (GO:0052803)6.11089970
18oxidative demethylation (GO:0070989)5.99044659
19ethanol metabolic process (GO:0006067)5.98050385
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91132411
21nitrogen cycle metabolic process (GO:0071941)5.89663721
22blood coagulation, intrinsic pathway (GO:0007597)5.87658485
23fibrinolysis (GO:0042730)5.86664347
24complement activation, classical pathway (GO:0006958)5.83821124
25* protein activation cascade (GO:0072376)5.78161318
26aromatic amino acid family catabolic process (GO:0009074)5.78101280
27* complement activation (GO:0006956)5.74397700
28bile acid biosynthetic process (GO:0006699)5.54675361
29acute-phase response (GO:0006953)5.52422953
30regulation of triglyceride catabolic process (GO:0010896)5.47814350
31disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.42591016
32killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.42591016
33cytolysis (GO:0019835)5.41044174
34urea cycle (GO:0000050)5.36154180
35serine family amino acid catabolic process (GO:0009071)5.35346355
36regulation of humoral immune response (GO:0002920)5.33130619
37regulation of plasminogen activation (GO:0010755)5.18337936
38negative regulation of protein activation cascade (GO:2000258)4.96251970
39bile acid metabolic process (GO:0008206)4.93579871
40cellular glucuronidation (GO:0052695)4.89275939
41* opsonization (GO:0008228)4.88836364
42phenylpropanoid metabolic process (GO:0009698)4.88137465
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.76989191
44negative regulation of sterol transport (GO:0032372)4.70799926
45negative regulation of cholesterol transport (GO:0032375)4.70799926
46S-adenosylmethionine metabolic process (GO:0046500)4.68753057
47glycine metabolic process (GO:0006544)4.68630753
48glucuronate metabolic process (GO:0019585)4.63389917
49uronic acid metabolic process (GO:0006063)4.63389917
50tyrosine metabolic process (GO:0006570)4.61416014
51positive regulation of triglyceride lipase activity (GO:0061365)4.55803138
52positive regulation of lipoprotein lipase activity (GO:0051006)4.55803138
53negative regulation of hemostasis (GO:1900047)4.52723235
54negative regulation of blood coagulation (GO:0030195)4.52723235
55glutamate metabolic process (GO:0006536)4.47368608
56triglyceride homeostasis (GO:0070328)4.44429896
57acylglycerol homeostasis (GO:0055090)4.44429896
58bile acid and bile salt transport (GO:0015721)4.41355949
59plasma lipoprotein particle remodeling (GO:0034369)4.24186603
60protein-lipid complex remodeling (GO:0034368)4.24186603
61macromolecular complex remodeling (GO:0034367)4.24186603
62indolalkylamine catabolic process (GO:0046218)4.21498047
63tryptophan catabolic process (GO:0006569)4.21498047
64indole-containing compound catabolic process (GO:0042436)4.21498047
65negative regulation of coagulation (GO:0050819)4.09563799
66negative regulation of wound healing (GO:0061045)4.07278651
67acute inflammatory response (GO:0002526)3.96388798
68alpha-amino acid catabolic process (GO:1901606)3.93539453
69negative regulation of complement activation (GO:0045916)3.92999093
70high-density lipoprotein particle remodeling (GO:0034375)3.91077339
71positive regulation of blood coagulation (GO:0030194)3.86214934
72positive regulation of hemostasis (GO:1900048)3.86214934
73cholesterol efflux (GO:0033344)3.84628113
74alkaloid metabolic process (GO:0009820)3.84489177
75cellular ketone body metabolic process (GO:0046950)3.78726279
76aromatic amino acid family metabolic process (GO:0009072)3.78362562
77regulation of acute inflammatory response (GO:0002673)3.73487187
78phospholipid efflux (GO:0033700)3.66395145
79amino-acid betaine metabolic process (GO:0006577)3.66144935
80reverse cholesterol transport (GO:0043691)3.62735607
81positive regulation of fatty acid biosynthetic process (GO:0045723)3.62524024
82tryptophan metabolic process (GO:0006568)3.61295190
83serine family amino acid metabolic process (GO:0009069)3.59354762
84arginine metabolic process (GO:0006525)3.57995982
85flavonoid metabolic process (GO:0009812)3.55715171
86oxaloacetate metabolic process (GO:0006107)3.54939861
87positive regulation of coagulation (GO:0050820)3.52738308
88regulation of apoptotic cell clearance (GO:2000425)3.49101600
89xenobiotic metabolic process (GO:0006805)3.44319021
90positive regulation of lipid catabolic process (GO:0050996)3.40536960
91negative regulation of lipase activity (GO:0060192)3.38650247
92regulation of cholesterol esterification (GO:0010872)3.36060196
93cellular amino acid catabolic process (GO:0009063)3.35406884
94hormone catabolic process (GO:0042447)3.33439191
95sodium-independent organic anion transport (GO:0043252)3.32862214
96ketone body metabolic process (GO:1902224)3.31573157
97response to mercury ion (GO:0046689)3.31397618
98exogenous drug catabolic process (GO:0042738)10.3697787
99omega-hydroxylase P450 pathway (GO:0097267)10.3024832
100complement activation, alternative pathway (GO:0006957)10.1513564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.79817483
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.74188486
3FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.74021139
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.60986784
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.53634286
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05228342
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95874905
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.61899349
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.75434674
10HTT_18923047_ChIP-ChIP_STHdh_Human2.00332022
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1170403
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99613276
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93757435
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.84004524
15HNF4A_19822575_ChIP-Seq_HepG2_Human1.79631589
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70379447
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65295506
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41093154
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.40651879
20GATA1_22025678_ChIP-Seq_K562_Human1.38737055
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34538250
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.28699364
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19743511
24BCAT_22108803_ChIP-Seq_LS180_Human1.15776467
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15392031
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.06020886
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04019093
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01910942
29ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98115313
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97128601
31* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96462278
32CBP_21632823_ChIP-Seq_H3396_Human0.94703951
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89782392
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89166464
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85492017
36RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85448046
37LXR_22292898_ChIP-Seq_THP-1_Human0.83225474
38HNFA_21074721_ChIP-Seq_CACO-2_Human0.82996541
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82476603
40CLOCK_20551151_ChIP-Seq_293T_Human0.80612232
41RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78018120
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75442674
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74166256
44PHF8_20622853_ChIP-Seq_HELA_Human0.73307556
45NFYA_21822215_ChIP-Seq_K562_Human0.71390154
46AR_20517297_ChIP-Seq_VCAP_Human0.70322349
47GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69360303
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68694137
49SPI1_20517297_ChIP-Seq_HL60_Human0.67884732
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67780858
51GATA4_25053715_ChIP-Seq_YYC3_Human0.65638670
52GATA6_21074721_ChIP-Seq_CACO-2_Human0.64139965
53KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63761189
54SOX2_21211035_ChIP-Seq_LN229_Human0.63680421
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63565983
56RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61762336
57TP53_18474530_ChIP-ChIP_U2OS_Human0.61268473
58RAC3_21632823_ChIP-Seq_H3396_Human0.59489172
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.59258943
60ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58944802
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57963890
62PIAS1_25552417_ChIP-Seq_VCAP_Human0.57835817
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56804817
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.56346889
65MYC_19915707_ChIP-ChIP_AK7_Human0.56240083
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56057192
67CEBPB_22108803_ChIP-Seq_LS180_Human0.55665150
68ERG_20517297_ChIP-Seq_VCAP_Human0.55619199
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.55247827
70IRF1_19129219_ChIP-ChIP_H3396_Human0.55222739
71DNAJC2_21179169_ChIP-ChIP_NT2_Human0.55169733
72BP1_19119308_ChIP-ChIP_Hs578T_Human0.54983896
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54815291
74FOXA1_25552417_ChIP-Seq_VCAP_Human0.54446070
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54391994
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.54092525
77E2F1_20622854_ChIP-Seq_HELA_Human0.53559886
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.53460825
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.53282823
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.52495745
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.51391267
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.51383062
83* MYC_19829295_ChIP-Seq_ESCs_Human0.51170697
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.51165447
85TAF2_19829295_ChIP-Seq_ESCs_Human0.51036537
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.51026176
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50884159
88CTCF_27219007_Chip-Seq_Bcells_Human0.50733506
89* SMC4_20622854_ChIP-Seq_HELA_Human0.50597512
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49802191
91ETV1_20927104_ChIP-Seq_GIST48_Human0.49722927
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.48765250
93NFYB_21822215_ChIP-Seq_K562_Human0.48585233
94SA1_27219007_Chip-Seq_Bcells_Human0.48208258
95SOX2_27498859_Chip-Seq_STOMACH_Mouse0.48021207
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.47451889
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.47395118
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.47330323
99CDX2_20551321_ChIP-Seq_CACO-2_Human0.46556138
100P53_21459846_ChIP-Seq_SAOS-2_Human0.46286149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.12941213
2MP0008875_abnormal_xenobiotic_pharmacok6.46026398
3MP0005085_abnormal_gallbladder_physiolo5.99998176
4MP0005360_urolithiasis5.57347341
5MP0005365_abnormal_bile_salt5.32056679
6MP0003195_calcinosis4.75826928
7MP0002138_abnormal_hepatobiliary_system4.21998899
8MP0003252_abnormal_bile_duct3.98507179
9MP0003191_abnormal_cellular_cholesterol3.50521340
10MP0010329_abnormal_lipoprotein_level2.99136795
11MP0001666_abnormal_nutrient_absorption2.80978455
12MP0010368_abnormal_lymphatic_system2.66184492
13MP0005670_abnormal_white_adipose2.45486335
14MP0005332_abnormal_amino_acid2.41605723
15MP0003868_abnormal_feces_composition2.40191551
16MP0009697_abnormal_copulation1.99399005
17MP0000609_abnormal_liver_physiology1.99141962
18MP0002118_abnormal_lipid_homeostasis1.88558828
19MP0009840_abnormal_foam_cell1.86779953
20MP0003806_abnormal_nucleotide_metabolis1.85210853
21MP0001764_abnormal_homeostasis1.62972180
22MP0002876_abnormal_thyroid_physiology1.54846626
23MP0001661_extended_life_span1.45080660
24MP0002132_abnormal_respiratory_system1.37923499
25MP0009764_decreased_sensitivity_to1.37826446
26MP0002971_abnormal_brown_adipose1.27681919
27MP0003656_abnormal_erythrocyte_physiolo1.26982706
28MP0009053_abnormal_anal_canal1.26112794
29MP0009763_increased_sensitivity_to1.14471202
30MP0004019_abnormal_vitamin_homeostasis1.10227730
31MP0005319_abnormal_enzyme/_coenzyme1.09674317
32MP0005584_abnormal_enzyme/coenzyme_acti1.09593289
33MP0000598_abnormal_liver_morphology1.09567558
34MP0004130_abnormal_muscle_cell1.07819337
35MP0002282_abnormal_trachea_morphology1.06218006
36MP0009643_abnormal_urine_homeostasis0.96988198
37MP0005408_hypopigmentation0.94266077
38MP0009642_abnormal_blood_homeostasis0.94002169
39MP0008872_abnormal_physiological_respon0.93215484
40MP0005535_abnormal_body_temperature0.91976993
41MP0005451_abnormal_body_composition0.91396300
42MP0005334_abnormal_fat_pad0.90373273
43MP0008469_abnormal_protein_level0.87180706
44MP0000604_amyloidosis0.86446099
45MP0005376_homeostasis/metabolism_phenot0.85409261
46MP0009785_altered_susceptibility_to0.85385553
47MP0003011_delayed_dark_adaptation0.84932297
48MP0003690_abnormal_glial_cell0.84851619
49MP0005636_abnormal_mineral_homeostasis0.84729573
50MP0002249_abnormal_larynx_morphology0.84214832
51MP0003186_abnormal_redox_activity0.82388876
52MP0005464_abnormal_platelet_physiology0.79230524
53MP0005666_abnormal_adipose_tissue0.75747545
54MP0002078_abnormal_glucose_homeostasis0.74215814
55MP0005266_abnormal_metabolism0.73759358
56MP0001915_intracranial_hemorrhage0.72932179
57MP0003879_abnormal_hair_cell0.72369045
58MP0009765_abnormal_xenobiotic_induced0.71567651
59MP0008874_decreased_physiological_sensi0.71545125
60MP0005166_decreased_susceptibility_to0.70053052
61MP0002332_abnormal_exercise_endurance0.64299306
62MP0005023_abnormal_wound_healing0.62254464
63MP0003075_altered_response_to0.58063085
64MP0000639_abnormal_adrenal_gland0.57022443
65MP0005187_abnormal_penis_morphology0.56968558
66MP0009115_abnormal_fat_cell0.55965242
67MP0002168_other_aberrant_phenotype0.54058942
68MP0005448_abnormal_energy_balance0.53889123
69MP0001545_abnormal_hematopoietic_system0.53649591
70MP0005397_hematopoietic_system_phenotyp0.53649591
71MP0000249_abnormal_blood_vessel0.53146596
72MP0005395_other_phenotype0.52502369
73MP0001881_abnormal_mammary_gland0.45517327
74MP0000467_abnormal_esophagus_morphology0.45463968
75MP0006036_abnormal_mitochondrial_physio0.45449510
76MP0003705_abnormal_hypodermis_morpholog0.45332758
77MP0003638_abnormal_response/metabolism_0.43904440
78MP0005083_abnormal_biliary_tract0.41049432
79MP0004883_abnormal_blood_vessel0.39220528
80MP0003953_abnormal_hormone_level0.39212096
81MP0005164_abnormal_response_to0.37463554
82MP0003436_decreased_susceptibility_to0.35746336
83MP0005375_adipose_tissue_phenotype0.34991790
84MP0004782_abnormal_surfactant_physiolog0.34776087
85MP0002136_abnormal_kidney_physiology0.34228266
86MP0002970_abnormal_white_adipose0.33244321
87MP0005377_hearing/vestibular/ear_phenot0.33064895
88MP0003878_abnormal_ear_physiology0.33064895
89MP0001845_abnormal_inflammatory_respons0.32582922
90MP0005595_abnormal_vascular_smooth0.31555031
91MP0005647_abnormal_sex_gland0.30075449
92MP0001851_eye_inflammation0.29486564
93MP0002909_abnormal_adrenal_gland0.28231309
94MP0002419_abnormal_innate_immunity0.27887410
95MP0002128_abnormal_blood_circulation0.26742232
96MP0006292_abnormal_olfactory_placode0.26739888
97MP0002295_abnormal_pulmonary_circulatio0.25506430
98MP0000678_abnormal_parathyroid_gland0.25235952
99MP0010155_abnormal_intestine_physiology0.24274691
100MP0003959_abnormal_lean_body0.24236701

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of complement system (HP:0005339)9.73936208
2Abnormality of monocarboxylic acid metabolism (HP:0010996)9.11900259
3Deep venous thrombosis (HP:0002625)9.00396366
4Prolonged partial thromboplastin time (HP:0003645)8.81544796
5Abnormality of aromatic amino acid family metabolism (HP:0004338)8.22046337
6Systemic lupus erythematosus (HP:0002725)7.14715683
7Conjugated hyperbilirubinemia (HP:0002908)7.09105886
8Hypobetalipoproteinemia (HP:0003563)6.91303377
9Joint hemorrhage (HP:0005261)6.63575895
10Hyperlipoproteinemia (HP:0010980)6.19847365
11Recurrent gram-negative bacterial infections (HP:0005420)6.16831751
12Glomerulonephritis (HP:0000099)5.50020198
13Spontaneous abortion (HP:0005268)5.15855892
14Intrahepatic cholestasis (HP:0001406)4.91947583
15Xanthomatosis (HP:0000991)4.82871391
16Abnormality of pyrimidine metabolism (HP:0004353)4.76060573
17Abnormality of the common coagulation pathway (HP:0010990)4.51484356
18Abnormality of the intrinsic pathway (HP:0010989)4.49324930
19Hypolipoproteinemia (HP:0010981)4.17236881
20Nephritis (HP:0000123)4.15911190
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.80246888
22Abnormality of methionine metabolism (HP:0010901)3.75413594
23Hypoalphalipoproteinemia (HP:0003233)3.71863167
24Neonatal hypoglycemia (HP:0001998)3.49131369
25Gingival bleeding (HP:0000225)3.33535479
26Thrombophlebitis (HP:0004418)3.01109496
27Hyperglycinemia (HP:0002154)2.98326029
28Hyperammonemia (HP:0001987)2.93613395
29Fat malabsorption (HP:0002630)2.82753560
30Delayed CNS myelination (HP:0002188)2.82487302
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78898332
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69914956
33Epidermoid cyst (HP:0200040)2.64570287
34Generalized aminoaciduria (HP:0002909)2.62021667
35Hyperbilirubinemia (HP:0002904)2.57842572
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.57569033
37Abnormality of nucleobase metabolism (HP:0010932)2.57439968
38Purpura (HP:0000979)2.57391117
39Hypercholesterolemia (HP:0003124)2.56133363
40Mitral stenosis (HP:0001718)2.51196007
41Hepatocellular carcinoma (HP:0001402)2.50556092
42Fair hair (HP:0002286)2.47395784
43Abnormality of glycine metabolism (HP:0010895)2.46358854
44Abnormality of serine family amino acid metabolism (HP:0010894)2.46358854
45Hemorrhage of the eye (HP:0011885)2.44033188
46Pulmonary embolism (HP:0002204)2.42388116
47Abnormality of serum amino acid levels (HP:0003112)2.25579215
48Joint swelling (HP:0001386)2.21964178
49Abnormality of iron homeostasis (HP:0011031)2.21879198
50Osteomalacia (HP:0002749)2.21631192
51Ketosis (HP:0001946)2.11205080
52Menorrhagia (HP:0000132)2.09006820
53Steatorrhea (HP:0002570)2.06786981
54Rickets (HP:0002748)2.06247546
55Vascular calcification (HP:0004934)2.04912156
56Complement deficiency (HP:0004431)12.0594925
57Epistaxis (HP:0000421)1.98460640
58Increased serum ferritin (HP:0003281)1.97257163
59Cholelithiasis (HP:0001081)1.96670827
60Abnormality of transition element cation homeostasis (HP:0011030)1.96177182
61Metabolic acidosis (HP:0001942)1.94333455
62Myocardial infarction (HP:0001658)1.91138290
63Elevated alkaline phosphatase (HP:0003155)1.89793791
64Hyperglycinuria (HP:0003108)1.88780687
65Cardiovascular calcification (HP:0011915)1.82904588
66Abnormal gallbladder morphology (HP:0012437)1.82736902
67Generalized hypopigmentation of hair (HP:0011358)1.77947553
68Abnormal enzyme/coenzyme activity (HP:0012379)1.77768148
69Atrioventricular block (HP:0001678)1.76520346
70Cerebral palsy (HP:0100021)1.76423864
71Gangrene (HP:0100758)1.75055383
72Skin nodule (HP:0200036)1.74197636
73Amyloidosis (HP:0011034)1.73493754
74Hyperphosphaturia (HP:0003109)1.72983146
75Abnormality of alkaline phosphatase activity (HP:0004379)1.72904210
76Increased serum pyruvate (HP:0003542)1.72440404
77Abnormal delivery (HP:0001787)1.69746540
78Increased mean platelet volume (HP:0011877)1.68121332
79Enlarged kidneys (HP:0000105)1.59612315
80Reduced antithrombin III activity (HP:0001976)1.59051099
81Neonatal onset (HP:0003623)1.58402431
82Abnormality of purine metabolism (HP:0004352)1.57238857
83Irritability (HP:0000737)1.55867889
84Pancreatitis (HP:0001733)1.55395685
85Blue irides (HP:0000635)1.55282496
86Abnormal platelet volume (HP:0011876)1.54380751
87Arthropathy (HP:0003040)1.53710995
88Gout (HP:0001997)1.53580678
89Spontaneous hematomas (HP:0007420)1.51638680
90Hypertriglyceridemia (HP:0002155)1.50949419
91Abnormality of vitamin metabolism (HP:0100508)1.47894438
92Poikilocytosis (HP:0004447)1.47488335
93Glycosuria (HP:0003076)1.46646364
94Abnormality of urine glucose concentration (HP:0011016)1.46646364
95Abnormality of glycolysis (HP:0004366)1.46037928
96Hypophosphatemic rickets (HP:0004912)1.44542759
97Abnormal platelet function (HP:0011869)1.41847104
98Impaired platelet aggregation (HP:0003540)1.41847104
99Visceral angiomatosis (HP:0100761)1.41004354
100Abnormal gallbladder physiology (HP:0012438)1.40038849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.73178099
2PIK3CG3.57606231
3TRIB33.56981826
4SIK13.36211037
5FGFR42.81779211
6BLK2.80398444
7PRPF4B2.80075902
8BCKDK2.75745196
9EPHA32.64324388
10TYK22.55159822
11RIPK12.41751606
12MAP2K41.87880234
13KDR1.86991673
14PRKAA21.80485433
15MAP3K121.77678007
16MAP4K11.76166196
17PRKACG1.74253031
18TAOK21.64145229
19CAMKK21.64049257
20NTRK31.63529852
21JAK11.59472436
22MYLK1.57991335
23MAP3K111.57295527
24PIK3CA1.52556031
25CSF1R1.44376343
26EPHB11.42165961
27TAOK31.40882303
28MAP3K31.37689529
29TNK21.36918451
30PDPK11.35123764
31AKT31.34753452
32ABL21.33422147
33PDK11.26031382
34PKN21.22146158
35TIE11.21997741
36MAP3K11.18505778
37IGF1R1.14009010
38JAK21.13698276
39MAP3K51.11629617
40MAPKAPK31.10117410
41CAMKK11.09822290
42MAPK111.05623761
43NLK1.05015698
44TGFBR20.99406717
45FER0.98328268
46MAP3K60.97086131
47ERBB20.92238413
48ZAP700.91159502
49CAMK1D0.90527838
50SCYL20.90288416
51FGFR30.90165793
52MAPK120.85350170
53RET0.84562742
54MAPK40.75123803
55MAPK70.74906801
56PRKACA0.70156429
57NEK90.70106058
58PRKG10.69338656
59TBK10.67366015
60MAP3K130.66484077
61CDK60.64689389
62PRKCZ0.63426103
63CAMK40.62265036
64PRKCG0.61021380
65PRKAA10.59142579
66ARAF0.57941728
67ADRBK10.55903956
68DAPK20.52747133
69PRKD10.50058812
70PTK60.49903034
71INSRR0.48737455
72MAPK30.46025729
73SYK0.42342385
74IKBKE0.37856394
75MAP2K30.37177843
76RPS6KA30.36869315
77PRKCA0.36625870
78DYRK1B0.35453686
79PINK10.35157509
80GSK3A0.34209863
81MELK0.33503033
82PRKACB0.33073625
83ICK0.32225356
84DDR20.31598468
85MST1R0.31327529
86CDK40.30982878
87IRAK10.30886877
88SRC0.30015679
89LCK0.28834077
90CAMK2G0.28641879
91JAK30.27276389
92PRKCQ0.24776864
93SGK30.24603174
94PRKCB0.24113843
95KIT0.24019271
96FYN0.23395827
97AKT20.22819691
98TESK20.22299286
99LYN0.20397126
100MAPK150.20239130

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.74341845
2Complement and coagulation cascades_Homo sapiens_hsa046104.36296753
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.34635212
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.56455941
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.53658217
6Retinol metabolism_Homo sapiens_hsa008303.40943566
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94113830
8Chemical carcinogenesis_Homo sapiens_hsa052042.85495441
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76926211
10Fatty acid degradation_Homo sapiens_hsa000712.68243775
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67771426
12Tyrosine metabolism_Homo sapiens_hsa003502.64035699
13Arginine biosynthesis_Homo sapiens_hsa002202.55288794
14Phenylalanine metabolism_Homo sapiens_hsa003602.54366199
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.37876749
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.27856247
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22318823
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14250819
19Histidine metabolism_Homo sapiens_hsa003402.13034266
20Linoleic acid metabolism_Homo sapiens_hsa005912.12153895
21Prion diseases_Homo sapiens_hsa050201.91160828
22Tryptophan metabolism_Homo sapiens_hsa003801.84004671
23Butanoate metabolism_Homo sapiens_hsa006501.79365298
24Staphylococcus aureus infection_Homo sapiens_hsa051501.73100347
25Vitamin B6 metabolism_Homo sapiens_hsa007501.56562840
26Bile secretion_Homo sapiens_hsa049761.55879114
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53589174
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49754017
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45595490
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43553863
31PPAR signaling pathway_Homo sapiens_hsa033201.42144467
32Arachidonic acid metabolism_Homo sapiens_hsa005901.34557496
33Starch and sucrose metabolism_Homo sapiens_hsa005001.30255138
34beta-Alanine metabolism_Homo sapiens_hsa004101.23390983
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.19353739
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.17557514
37Peroxisome_Homo sapiens_hsa041461.11507231
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08241178
39Pyruvate metabolism_Homo sapiens_hsa006201.07625944
40Biosynthesis of amino acids_Homo sapiens_hsa012301.05617504
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98492971
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93726058
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85831409
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84383398
45Propanoate metabolism_Homo sapiens_hsa006400.80976670
46One carbon pool by folate_Homo sapiens_hsa006700.80367082
47ABC transporters_Homo sapiens_hsa020100.79504148
48Carbon metabolism_Homo sapiens_hsa012000.78540947
49Arginine and proline metabolism_Homo sapiens_hsa003300.78252675
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72535249
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71264382
52Fat digestion and absorption_Homo sapiens_hsa049750.67573684
53Fatty acid metabolism_Homo sapiens_hsa012120.65508788
54Pertussis_Homo sapiens_hsa051330.51053576
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42909051
56Metabolic pathways_Homo sapiens_hsa011000.38739850
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.35888522
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33927506
59Systemic lupus erythematosus_Homo sapiens_hsa053220.33647774
60Lysine degradation_Homo sapiens_hsa003100.33366862
61Insulin resistance_Homo sapiens_hsa049310.33106778
62Glycerolipid metabolism_Homo sapiens_hsa005610.32265453
63Sulfur relay system_Homo sapiens_hsa041220.31479951
64Sulfur metabolism_Homo sapiens_hsa009200.30110341
65Glucagon signaling pathway_Homo sapiens_hsa049220.22958769
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.21643865
67Amoebiasis_Homo sapiens_hsa051460.19350943
68Pentose phosphate pathway_Homo sapiens_hsa000300.18474311
69Mineral absorption_Homo sapiens_hsa049780.16030356
70Fructose and mannose metabolism_Homo sapiens_hsa000510.14381077
71Fatty acid elongation_Homo sapiens_hsa000620.13168928
72AMPK signaling pathway_Homo sapiens_hsa041520.12963931
73Fatty acid biosynthesis_Homo sapiens_hsa000610.08308055
74Serotonergic synapse_Homo sapiens_hsa047260.02622350
75Renin-angiotensin system_Homo sapiens_hsa046140.02438350
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00815622
77Prolactin signaling pathway_Homo sapiens_hsa04917-0.2665238
78Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2501149
79FoxO signaling pathway_Homo sapiens_hsa04068-0.2359722
80Platelet activation_Homo sapiens_hsa04611-0.2335691
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.2260210
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2235982
83Circadian rhythm_Homo sapiens_hsa04710-0.1798265
84Steroid biosynthesis_Homo sapiens_hsa00100-0.1656975
85Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1620616
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1554993
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1316237
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1198964
89Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1185620
90Glutathione metabolism_Homo sapiens_hsa00480-0.1152589
91Other glycan degradation_Homo sapiens_hsa00511-0.1129983
92Galactose metabolism_Homo sapiens_hsa00052-0.1081311
93Nitrogen metabolism_Homo sapiens_hsa00910-0.0961271
94Folate biosynthesis_Homo sapiens_hsa00790-0.0825702
95African trypanosomiasis_Homo sapiens_hsa05143-0.0709631
96Insulin signaling pathway_Homo sapiens_hsa04910-0.0698985
97Selenocompound metabolism_Homo sapiens_hsa00450-0.0697239
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0545443
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0519784
100Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0475298

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