FCN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.35148710
2exogenous drug catabolic process (GO:0042738)8.88183346
3omega-hydroxylase P450 pathway (GO:0097267)8.73630295
4epoxygenase P450 pathway (GO:0019373)8.61941078
5regulation of protein activation cascade (GO:2000257)8.35503649
6drug catabolic process (GO:0042737)8.25843747
7ethanol oxidation (GO:0006069)8.24396672
8regulation of complement activation (GO:0030449)8.14985726
9regulation of fibrinolysis (GO:0051917)7.38065729
10glyoxylate metabolic process (GO:0046487)7.13108578
11negative regulation of fibrinolysis (GO:0051918)6.85443164
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.67857393
13L-phenylalanine catabolic process (GO:0006559)6.67857393
14ethanol metabolic process (GO:0006067)6.58819774
15blood coagulation, intrinsic pathway (GO:0007597)6.17562267
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.09268031
17L-phenylalanine metabolic process (GO:0006558)6.09268031
18protein carboxylation (GO:0018214)6.01771271
19peptidyl-glutamic acid carboxylation (GO:0017187)6.01771271
20complement activation, classical pathway (GO:0006958)6.01514801
21drug metabolic process (GO:0017144)5.97615323
22* protein activation cascade (GO:0072376)5.97210991
23* complement activation (GO:0006956)5.92880514
24opsonization (GO:0008228)5.90444461
25urea metabolic process (GO:0019627)5.83847410
26negative regulation of protein activation cascade (GO:2000258)5.80344769
27fibrinolysis (GO:0042730)5.79177422
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66869983
29imidazole-containing compound metabolic process (GO:0052803)5.50721921
30nitrogen cycle metabolic process (GO:0071941)5.38312007
31oxidative demethylation (GO:0070989)5.19279876
32regulation of humoral immune response (GO:0002920)5.15978068
33negative regulation of complement activation (GO:0045916)5.15772256
34regulation of plasminogen activation (GO:0010755)5.07280879
35acute-phase response (GO:0006953)5.03262862
36surfactant homeostasis (GO:0043129)5.00127629
37aromatic amino acid family catabolic process (GO:0009074)4.93646598
38urea cycle (GO:0000050)4.88853148
39regulation of triglyceride catabolic process (GO:0010896)4.83774223
40bile acid biosynthetic process (GO:0006699)4.73255906
41cytolysis (GO:0019835)4.56682100
42negative regulation of blood coagulation (GO:0030195)4.52422888
43negative regulation of hemostasis (GO:1900047)4.52422888
44disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.48832676
45killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.48832676
46serine family amino acid catabolic process (GO:0009071)4.46651325
47negative regulation of sterol transport (GO:0032372)4.45283590
48negative regulation of cholesterol transport (GO:0032375)4.45283590
49cellular glucuronidation (GO:0052695)4.39539472
50phenylpropanoid metabolic process (GO:0009698)4.26985464
51bile acid metabolic process (GO:0008206)4.24224273
52glutamate metabolic process (GO:0006536)4.15649003
53negative regulation of humoral immune response (GO:0002921)4.15382838
54uronic acid metabolic process (GO:0006063)4.14529958
55glucuronate metabolic process (GO:0019585)4.14529958
56negative regulation of coagulation (GO:0050819)4.12773538
57positive regulation of lipoprotein lipase activity (GO:0051006)4.10311452
58positive regulation of triglyceride lipase activity (GO:0061365)4.10311452
59triglyceride homeostasis (GO:0070328)4.09796358
60acylglycerol homeostasis (GO:0055090)4.09796358
61negative regulation of wound healing (GO:0061045)4.04677059
62chemical homeostasis within a tissue (GO:0048875)4.01434057
63tyrosine metabolic process (GO:0006570)3.96227052
64plasma lipoprotein particle remodeling (GO:0034369)3.95090584
65protein-lipid complex remodeling (GO:0034368)3.95090584
66macromolecular complex remodeling (GO:0034367)3.95090584
67positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.93936016
68S-adenosylmethionine metabolic process (GO:0046500)3.91288289
69positive regulation of hemostasis (GO:1900048)3.84828192
70positive regulation of blood coagulation (GO:0030194)3.84828192
71glycine metabolic process (GO:0006544)3.83438456
72bile acid and bile salt transport (GO:0015721)3.82450780
73response to mercury ion (GO:0046689)3.79024604
74high-density lipoprotein particle remodeling (GO:0034375)3.66951620
75acute inflammatory response (GO:0002526)3.65979771
76regulation of acute inflammatory response (GO:0002673)3.61268108
77phospholipid efflux (GO:0033700)3.56184082
78cholesterol efflux (GO:0033344)3.54203860
79positive regulation of coagulation (GO:0050820)3.53748099
80alpha-amino acid catabolic process (GO:1901606)3.50262776
81regulation of apoptotic cell clearance (GO:2000425)3.47755814
82cellular ketone body metabolic process (GO:0046950)3.44178492
83sodium-independent organic anion transport (GO:0043252)3.44066714
84negative regulation of lipase activity (GO:0060192)3.39834818
85indole-containing compound catabolic process (GO:0042436)3.38792558
86indolalkylamine catabolic process (GO:0046218)3.38792558
87tryptophan catabolic process (GO:0006569)3.38792558
88reverse cholesterol transport (GO:0043691)3.35145638
89hormone catabolic process (GO:0042447)3.34615047
90alkaloid metabolic process (GO:0009820)3.32914177
91regulation of cholesterol esterification (GO:0010872)3.32477092
92arginine metabolic process (GO:0006525)3.31135175
93positive regulation of lipid catabolic process (GO:0050996)3.22190290
94amino-acid betaine metabolic process (GO:0006577)3.19719151
95aromatic amino acid family metabolic process (GO:0009072)3.16910485
96xenobiotic metabolic process (GO:0006805)3.14311420
97primary alcohol metabolic process (GO:0034308)3.13222015
98phosphate ion transmembrane transport (GO:0035435)3.11796236
99renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.11405523
100plasma lipoprotein particle clearance (GO:0034381)3.09745775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.16485652
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.55638025
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.11087622
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.88087273
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.82444470
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.57168008
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.36330532
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63237129
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31045810
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.29584560
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85226736
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.58091904
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87579838
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82688923
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.79067213
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64408671
17GATA1_22025678_ChIP-Seq_K562_Human1.59939335
18CLOCK_20551151_ChIP-Seq_293T_Human1.58180983
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54069028
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48069986
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47311631
22HTT_18923047_ChIP-ChIP_STHdh_Human1.46188434
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.45026543
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.41706197
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40038316
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.36695747
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.25201939
28TBX20_22080862_ChIP-Seq_HEART_Mouse1.25201939
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.23865669
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23656513
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.23181723
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.21784368
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20951848
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20563185
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09126818
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03446036
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01587049
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00617955
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99664331
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98729745
41CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94612200
42TCF4_18268006_ChIP-ChIP_LS174T_Human0.93065429
43SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92628947
44IRF8_22096565_ChIP-ChIP_GC-B_Human0.92291830
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92098881
46GATA4_25053715_ChIP-Seq_YYC3_Human0.91001723
47ESR1_21235772_ChIP-Seq_MCF-7_Human0.90087804
48BCAT_22108803_ChIP-Seq_LS180_Human0.88620287
49LXR_22292898_ChIP-Seq_THP-1_Human0.88618931
50CDX2_20551321_ChIP-Seq_CACO-2_Human0.87705650
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87453559
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84530615
53STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83290664
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82675681
55NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81841666
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81194006
57PIAS1_25552417_ChIP-Seq_VCAP_Human0.80797255
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80790513
59CBP_21632823_ChIP-Seq_H3396_Human0.80340254
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79188388
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77482758
62GATA1_19941827_ChIP-Seq_MEL_Mouse0.77038486
63SOX2_20726797_ChIP-Seq_SW620_Human0.74477391
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74421814
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72561701
66PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71805332
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71077129
68SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69474296
69* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68522908
70RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68494055
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67611750
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66737177
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.66472471
74TP53_18474530_ChIP-ChIP_U2OS_Human0.64486552
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63517639
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.62694853
77* HNFA_21074721_ChIP-Seq_CACO-2_Human0.62554570
78RXRA_24833708_ChIP-Seq_LIVER_Mouse0.61259418
79DROSHA_22980978_ChIP-Seq_HELA_Human0.60652517
80GATA1_19941826_ChIP-Seq_K562_Human0.59307883
81MYC_27129775_Chip-Seq_CORNEA_Mouse0.59109170
82CJUN_26792858_Chip-Seq_BT549_Human0.58884335
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58864015
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58864015
85* PHF8_20622853_ChIP-Seq_HELA_Human0.58757208
86NFYA_21822215_ChIP-Seq_K562_Human0.58678430
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58319811
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.57913624
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.57650368
90* CTCF_27219007_Chip-Seq_Bcells_Human0.57391104
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.56804383
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55093016
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.54970086
94GF1_26923725_Chip-Seq_HPCs_Mouse0.54087723
95SMC4_20622854_ChIP-Seq_HELA_Human0.53605814
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.53472019
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.53458878
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.53114809
99CEBPB_22108803_ChIP-Seq_LS180_Human0.53022055
100* SOX2_21211035_ChIP-Seq_LN229_Human0.52814815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.38543460
2MP0008875_abnormal_xenobiotic_pharmacok5.38209695
3MP0005360_urolithiasis5.19182944
4MP0005085_abnormal_gallbladder_physiolo5.07761752
5MP0005365_abnormal_bile_salt4.34208864
6MP0003195_calcinosis4.31502135
7MP0010368_abnormal_lymphatic_system4.10296362
8MP0002138_abnormal_hepatobiliary_system4.04152889
9MP0004782_abnormal_surfactant_physiolog3.42962175
10MP0003252_abnormal_bile_duct3.11315923
11MP0003191_abnormal_cellular_cholesterol3.00753870
12MP0010329_abnormal_lipoprotein_level2.43365730
13MP0001666_abnormal_nutrient_absorption2.28853203
14MP0005670_abnormal_white_adipose2.21233216
15MP0005332_abnormal_amino_acid2.19698241
16MP0003868_abnormal_feces_composition2.12999981
17MP0009840_abnormal_foam_cell2.09560900
18MP0002118_abnormal_lipid_homeostasis1.72961052
19MP0001958_emphysema1.65109211
20MP0004084_abnormal_cardiac_muscle1.63686812
21MP0009697_abnormal_copulation1.62932503
22MP0000609_abnormal_liver_physiology1.55655642
23MP0004272_abnormal_basement_membrane1.54632108
24MP0006138_congestive_heart_failure1.49906239
25MP0003806_abnormal_nucleotide_metabolis1.45464780
26MP0005451_abnormal_body_composition1.34239333
27MP0001661_extended_life_span1.33613332
28MP0001879_abnormal_lymphatic_vessel1.26768826
29MP0002876_abnormal_thyroid_physiology1.19557101
30MP0002295_abnormal_pulmonary_circulatio1.17789482
31MP0005330_cardiomyopathy1.17266512
32MP0002132_abnormal_respiratory_system1.17100708
33MP0002332_abnormal_exercise_endurance1.15046221
34MP0002971_abnormal_brown_adipose1.09741503
35MP0004036_abnormal_muscle_relaxation1.08454699
36MP0004215_abnormal_myocardial_fiber1.08248885
37MP0003828_pulmonary_edema1.07970357
38MP0000249_abnormal_blood_vessel1.05248916
39MP0009764_decreased_sensitivity_to1.04058369
40MP0009763_increased_sensitivity_to1.03194133
41MP0003656_abnormal_erythrocyte_physiolo1.02953818
42MP0009643_abnormal_urine_homeostasis1.02394523
43MP0004130_abnormal_muscle_cell1.01610028
44MP0008775_abnormal_heart_ventricle1.00764950
45MP0005388_respiratory_system_phenotype0.99145159
46MP0002133_abnormal_respiratory_system0.99145159
47MP0005584_abnormal_enzyme/coenzyme_acti0.98873585
48MP0001544_abnormal_cardiovascular_syste0.98473757
49MP0005385_cardiovascular_system_phenoty0.98473757
50MP0009053_abnormal_anal_canal0.97652941
51MP0001764_abnormal_homeostasis0.97123479
52MP0005167_abnormal_blood-brain_barrier0.96733538
53MP0005165_increased_susceptibility_to0.95740305
54MP0001915_intracranial_hemorrhage0.95292133
55MP0005595_abnormal_vascular_smooth0.94105307
56MP0004883_abnormal_blood_vessel0.91971181
57MP0008004_abnormal_stomach_pH0.91613245
58MP0000751_myopathy0.90644414
59MP0005164_abnormal_response_to0.89238265
60MP0002837_dystrophic_cardiac_calcinosis0.88462432
61MP0003705_abnormal_hypodermis_morpholog0.87696753
62MP0005376_homeostasis/metabolism_phenot0.87670453
63MP0003690_abnormal_glial_cell0.87613483
64MP0000598_abnormal_liver_morphology0.86746229
65MP0005023_abnormal_wound_healing0.86363060
66MP0001851_eye_inflammation0.84354351
67MP0005535_abnormal_body_temperature0.83213116
68MP0005319_abnormal_enzyme/_coenzyme0.82546647
69MP0003724_increased_susceptibility_to0.81611811
70MP0005083_abnormal_biliary_tract0.80877656
71MP0004019_abnormal_vitamin_homeostasis0.78864320
72MP0003566_abnormal_cell_adhesion0.77024685
73MP0000604_amyloidosis0.76897600
74MP0002168_other_aberrant_phenotype0.74932613
75MP0008995_early_reproductive_senescence0.74738588
76MP0009642_abnormal_blood_homeostasis0.74576942
77MP0002128_abnormal_blood_circulation0.74047849
78MP0005334_abnormal_fat_pad0.72347773
79MP0001545_abnormal_hematopoietic_system0.71319871
80MP0005397_hematopoietic_system_phenotyp0.71319871
81MP0005266_abnormal_metabolism0.70202271
82MP0008469_abnormal_protein_level0.68169470
83MP0002972_abnormal_cardiac_muscle0.67042950
84MP0005666_abnormal_adipose_tissue0.66730478
85MP0001542_abnormal_bone_strength0.65684752
86MP0005408_hypopigmentation0.65580270
87MP0000343_altered_response_to0.65284686
88MP0010630_abnormal_cardiac_muscle0.64911338
89MP0005166_decreased_susceptibility_to0.63922035
90MP0003075_altered_response_to0.63499352
91MP0002282_abnormal_trachea_morphology0.63189932
92MP0004484_altered_response_of0.62408984
93MP0005464_abnormal_platelet_physiology0.59520117
94MP0008874_decreased_physiological_sensi0.58238479
95MP0009785_altered_susceptibility_to0.56614980
96MP0003011_delayed_dark_adaptation0.56065563
97MP0004510_myositis0.55041766
98MP0002078_abnormal_glucose_homeostasis0.54763528
99MP0005187_abnormal_penis_morphology0.53536093
100MP0003186_abnormal_redox_activity0.53268894

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of complement system (HP:0005339)9.30315411
2Abnormality of monocarboxylic acid metabolism (HP:0010996)8.56208600
3Deep venous thrombosis (HP:0002625)8.37745051
4Prolonged partial thromboplastin time (HP:0003645)7.86841118
5Systemic lupus erythematosus (HP:0002725)7.65491791
6Abnormality of aromatic amino acid family metabolism (HP:0004338)7.16124349
7Joint hemorrhage (HP:0005261)6.39100757
8Glomerulonephritis (HP:0000099)5.91279762
9Hypobetalipoproteinemia (HP:0003563)5.76287665
10Hyperlipoproteinemia (HP:0010980)5.64916475
11Conjugated hyperbilirubinemia (HP:0002908)5.62183106
12Recurrent gram-negative bacterial infections (HP:0005420)5.62140509
13Xanthomatosis (HP:0000991)4.69950170
14Nephritis (HP:0000123)4.42079730
15Abnormality of the intrinsic pathway (HP:0010989)4.39573923
16Interstitial pulmonary disease (HP:0006530)4.35072032
17Intrahepatic cholestasis (HP:0001406)4.27039694
18Spontaneous abortion (HP:0005268)4.14213078
19Abnormality of the common coagulation pathway (HP:0010990)3.91305401
20Abnormality of pyrimidine metabolism (HP:0004353)3.86339101
21Hypolipoproteinemia (HP:0010981)3.73801610
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55360551
23Hypoalphalipoproteinemia (HP:0003233)3.43856155
24Vascular calcification (HP:0004934)2.90895145
25Hemorrhage of the eye (HP:0011885)2.89929912
26Abnormality of methionine metabolism (HP:0010901)2.85357499
27Epidermoid cyst (HP:0200040)2.83735690
28Neonatal hypoglycemia (HP:0001998)2.79895209
29Delayed CNS myelination (HP:0002188)2.76161883
30Thrombophlebitis (HP:0004418)2.74366758
31Myocardial infarction (HP:0001658)2.72872132
32Atrioventricular block (HP:0001678)2.71802345
33Purpura (HP:0000979)2.64979864
34Mitral stenosis (HP:0001718)2.64011248
35Gingival bleeding (HP:0000225)2.63153104
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62881489
37Cardiovascular calcification (HP:0011915)2.59824209
38Fat malabsorption (HP:0002630)2.51302803
39Hypercholesterolemia (HP:0003124)2.49395010
40Hyperammonemia (HP:0001987)2.48080531
41Skin nodule (HP:0200036)2.38391756
42Spontaneous hematomas (HP:0007420)2.37461435
43Fair hair (HP:0002286)2.32358452
44Pulmonary embolism (HP:0002204)2.29577582
45Esophageal varix (HP:0002040)2.27777393
46Polycythemia (HP:0001901)2.24795804
47Hyperglycinemia (HP:0002154)2.21267943
48Menorrhagia (HP:0000132)2.20355016
49Abnormality of nucleobase metabolism (HP:0010932)2.19145529
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15228573
51Joint swelling (HP:0001386)2.08741214
52Cerebral palsy (HP:0100021)2.08146417
53Rickets (HP:0002748)2.08042816
54Generalized aminoaciduria (HP:0002909)2.07506137
55Abnormality of serine family amino acid metabolism (HP:0010894)2.05479346
56Abnormality of glycine metabolism (HP:0010895)2.05479346
57Osteomalacia (HP:0002749)2.04657369
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.04260959
59Steatorrhea (HP:0002570)2.01751458
60Complement deficiency (HP:0004431)11.3875929
61Hyperbilirubinemia (HP:0002904)1.98987801
62Respiratory distress (HP:0002098)1.98901228
63Abnormal atrioventricular conduction (HP:0005150)1.98595046
64Heart block (HP:0012722)1.97401833
65Hepatocellular carcinoma (HP:0001402)1.93465373
66Visceral angiomatosis (HP:0100761)1.92274608
67Tachypnea (HP:0002789)1.90773951
68Epistaxis (HP:0000421)1.89819839
69Abnormality of iron homeostasis (HP:0011031)1.82016362
70Blue irides (HP:0000635)1.80230779
71Metabolic acidosis (HP:0001942)1.78290272
72Hemangiomatosis (HP:0007461)1.77855152
73Abnormality of serum amino acid levels (HP:0003112)1.77394319
74Ketosis (HP:0001946)1.75000041
75Stroke (HP:0001297)1.73954105
76Amyloidosis (HP:0011034)1.73438248
77Generalized hypopigmentation of hair (HP:0011358)1.71568239
78Conjunctival telangiectasia (HP:0000524)1.71511961
79Lymphangioma (HP:0100764)1.69911528
80Cholelithiasis (HP:0001081)1.69659715
81Hyperglycinuria (HP:0003108)1.64260948
82Sudden death (HP:0001699)1.62981122
83Abnormal platelet function (HP:0011869)1.60261398
84Impaired platelet aggregation (HP:0003540)1.60261398
85Abnormal gallbladder morphology (HP:0012437)1.56531688
86Abnormality of transition element cation homeostasis (HP:0011030)1.56380237
87Increased serum ferritin (HP:0003281)1.54300531
88Hypertriglyceridemia (HP:0002155)1.52960741
89Elevated alkaline phosphatase (HP:0003155)1.50491065
90Gout (HP:0001997)1.49003029
91Abnormal enzyme/coenzyme activity (HP:0012379)1.48188015
92Increased mean platelet volume (HP:0011877)1.48010355
93Abnormality of the Achilles tendon (HP:0005109)1.47631510
94Gangrene (HP:0100758)1.42581711
95Abnormality of purine metabolism (HP:0004352)1.42515142
96Abnormality of alkaline phosphatase activity (HP:0004379)1.42217569
97Abnormality of the fingertips (HP:0001211)1.41085508
98Hypophosphatemic rickets (HP:0004912)1.40946073
99Asymmetric septal hypertrophy (HP:0001670)1.40482554
100Abnormal gallbladder physiology (HP:0012438)1.39996528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.78703163
2KDR4.57633771
3ERN13.53419782
4TGFBR23.27917165
5MYLK3.24884518
6EPHA33.08252386
7RIPK12.89799085
8FGFR42.87341194
9TRIB32.29885775
10FER2.25748364
11EPHB12.18956086
12TTN1.93973026
13MAP3K61.64429024
14NLK1.45480650
15PRPF4B1.43784125
16PRKAA21.36196752
17PDPK11.34138245
18EPHB21.32693870
19CDC42BPA1.32262662
20MAP3K31.32098155
21TYK21.26699642
22FGFR31.23405252
23PRKD11.19450985
24MST1R1.19186099
25NEK91.18094213
26SIK11.17044179
27MAPK121.16290332
28PRKACG1.13721462
29ZAP701.13261313
30PDK21.10635623
31JAK11.07268457
32OBSCN1.04159661
33PIK3CG1.01150283
34DMPK0.96621844
35FES0.94063867
36NTRK30.88280314
37LRRK20.88224704
38MAPK150.87118775
39MET0.85728750
40TRPM70.85622902
41IGF1R0.85048086
42AKT30.82635013
43MAP3K10.82626712
44MAPK70.78446914
45PIK3CA0.78179559
46IRAK10.77173786
47PKN20.76790398
48MAPK40.73334071
49RPS6KA20.70471400
50SGK20.69397594
51SGK30.67623231
52MAP3K130.67246911
53TBK10.67190914
54ROCK10.66552442
55PAK30.66105347
56BCKDK0.65193969
57PRKG10.65032737
58PDGFRA0.63375926
59ABL20.61578679
60CSK0.61465275
61MARK20.61360710
62DAPK20.61082904
63MAP3K70.60431812
64RET0.59534980
65JAK20.55736362
66EPHA20.55494234
67PDK10.54354009
68GSK3A0.53442586
69MAP2K30.53205285
70PRKACA0.53109993
71PRKCE0.52915129
72SGK2230.52367433
73SGK4940.52367433
74NTRK10.52018067
75LATS10.50012512
76PDGFRB0.49926720
77MAPKAPK30.49181752
78MOS0.48450905
79STK100.47978664
80ROCK20.47543387
81PRKACB0.46658811
82GRK70.46589540
83GRK50.46577102
84ERBB20.45813677
85DAPK30.45786816
86MAPK110.44164679
87CDK60.44152619
88PTK60.41004764
89RPS6KC10.39533925
90RPS6KL10.39533925
91PRKG20.38233387
92PRKAA10.36995518
93PAK40.34448763
94LMTK20.34354446
95MUSK0.33667777
96MAP3K50.32839595
97SRC0.32440475
98KSR20.31911528
99PRKCA0.30746331
100PINK10.30691824

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.62058493
2Caffeine metabolism_Homo sapiens_hsa002324.31140758
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.18794689
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.52169654
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.33903335
6Retinol metabolism_Homo sapiens_hsa008303.32931784
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92163958
8Fatty acid degradation_Homo sapiens_hsa000712.91098350
9Tyrosine metabolism_Homo sapiens_hsa003502.80133755
10Chemical carcinogenesis_Homo sapiens_hsa052042.75549056
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.73534280
12Phenylalanine metabolism_Homo sapiens_hsa003602.70423889
13Arginine biosynthesis_Homo sapiens_hsa002202.64567204
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50226108
15Histidine metabolism_Homo sapiens_hsa003402.36280211
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19755857
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.12048872
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05451057
19Drug metabolism - other enzymes_Homo sapiens_hsa009832.01963753
20Linoleic acid metabolism_Homo sapiens_hsa005912.00319949
21Prion diseases_Homo sapiens_hsa050201.95207804
22Tryptophan metabolism_Homo sapiens_hsa003801.93763515
23Staphylococcus aureus infection_Homo sapiens_hsa051501.81989180
24Bile secretion_Homo sapiens_hsa049761.63472079
25Butanoate metabolism_Homo sapiens_hsa006501.61490558
26PPAR signaling pathway_Homo sapiens_hsa033201.46173639
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40014030
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39819098
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33956539
30Arachidonic acid metabolism_Homo sapiens_hsa005901.33801619
31Starch and sucrose metabolism_Homo sapiens_hsa005001.29162610
32beta-Alanine metabolism_Homo sapiens_hsa004101.26401680
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.17983715
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13195091
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10347800
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07552380
37Vitamin B6 metabolism_Homo sapiens_hsa007501.05568805
38Pyruvate metabolism_Homo sapiens_hsa006201.05115825
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03984288
40Peroxisome_Homo sapiens_hsa041460.99957574
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.99358566
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99322014
43Biosynthesis of amino acids_Homo sapiens_hsa012300.95633022
44Arginine and proline metabolism_Homo sapiens_hsa003300.89765555
45ABC transporters_Homo sapiens_hsa020100.89206107
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83314561
47Pertussis_Homo sapiens_hsa051330.83270405
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81289246
49Carbon metabolism_Homo sapiens_hsa012000.79065498
50Propanoate metabolism_Homo sapiens_hsa006400.75031186
51Fatty acid metabolism_Homo sapiens_hsa012120.66496232
52Fat digestion and absorption_Homo sapiens_hsa049750.64301925
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60349356
54One carbon pool by folate_Homo sapiens_hsa006700.48560019
55Insulin resistance_Homo sapiens_hsa049310.39517091
56Amoebiasis_Homo sapiens_hsa051460.36361129
57Mineral absorption_Homo sapiens_hsa049780.35421788
58Glycerolipid metabolism_Homo sapiens_hsa005610.34714845
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33702262
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30354711
61Metabolic pathways_Homo sapiens_hsa011000.29220570
62Lysine degradation_Homo sapiens_hsa003100.28875524
63Sulfur metabolism_Homo sapiens_hsa009200.26856605
64Systemic lupus erythematosus_Homo sapiens_hsa053220.25512045
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.24253004
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.22107222
67Glucagon signaling pathway_Homo sapiens_hsa049220.21771205
68Sulfur relay system_Homo sapiens_hsa041220.20270340
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18722871
70Dilated cardiomyopathy_Homo sapiens_hsa054140.17860709
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.16360662
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.15815681
73Pentose phosphate pathway_Homo sapiens_hsa000300.15122872
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13914192
75ECM-receptor interaction_Homo sapiens_hsa045120.12080054
76Fatty acid elongation_Homo sapiens_hsa000620.09639988
77Serotonergic synapse_Homo sapiens_hsa047260.08804543
78Fructose and mannose metabolism_Homo sapiens_hsa000510.06988256
79AMPK signaling pathway_Homo sapiens_hsa041520.06794092
80Ovarian steroidogenesis_Homo sapiens_hsa049130.03705115
81Fatty acid biosynthesis_Homo sapiens_hsa000610.03522997
82Selenocompound metabolism_Homo sapiens_hsa004500.02425303
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.1296021
84Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1189203
85Protein digestion and absorption_Homo sapiens_hsa04974-0.1157994
86African trypanosomiasis_Homo sapiens_hsa05143-0.1081510
87Renin secretion_Homo sapiens_hsa04924-0.1033338
88Folate biosynthesis_Homo sapiens_hsa00790-0.1027642
89Tight junction_Homo sapiens_hsa04530-0.0985228
90Circadian rhythm_Homo sapiens_hsa04710-0.0820588
91Platelet activation_Homo sapiens_hsa04611-0.0748060
92Phagosome_Homo sapiens_hsa04145-0.0687102
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0664004
94Renin-angiotensin system_Homo sapiens_hsa04614-0.0607208
95Focal adhesion_Homo sapiens_hsa04510-0.0585508
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0554868
97Insulin signaling pathway_Homo sapiens_hsa04910-0.0501163
98Glutathione metabolism_Homo sapiens_hsa00480-0.0499969
99Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0312397
100Other glycan degradation_Homo sapiens_hsa00511-0.0192374

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