FCRL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)8.39665737
2antigen processing and presentation of endogenous antigen (GO:0019883)7.74646156
3regulation of B cell receptor signaling pathway (GO:0050855)7.36959638
4positive regulation of gamma-delta T cell activation (GO:0046645)6.30540487
5regulation of B cell differentiation (GO:0045577)5.90935678
6cellular response to zinc ion (GO:0071294)5.76443810
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.62560864
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.62560864
9cytidine metabolic process (GO:0046087)5.25684285
10cytidine catabolic process (GO:0006216)5.25684285
11cytidine deamination (GO:0009972)5.25684285
12positive regulation of B cell differentiation (GO:0045579)5.08563726
13B cell proliferation (GO:0042100)5.07046724
14positive thymic T cell selection (GO:0045059)5.03617136
15regulation of interferon-beta biosynthetic process (GO:0045357)4.93865459
16regulation of gamma-delta T cell differentiation (GO:0045586)4.70270992
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.68374642
18mature B cell differentiation (GO:0002335)4.65905171
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56265353
20production of molecular mediator involved in inflammatory response (GO:0002532)4.54358060
21cellular response to interleukin-15 (GO:0071350)4.53671974
22response to interleukin-15 (GO:0070672)4.48765883
23regulation of gamma-delta T cell activation (GO:0046643)4.38670563
24regulation of B cell proliferation (GO:0030888)4.35322878
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.34735377
26negative regulation of T-helper cell differentiation (GO:0045623)4.34333753
27negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.34333753
28negative regulation of B cell proliferation (GO:0030889)4.34296037
29regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.33788419
30regulation of interleukin-12 biosynthetic process (GO:0045075)4.30456060
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25478583
32defense response to protozoan (GO:0042832)4.22804001
33detection of other organism (GO:0098543)4.18382467
34detection of bacterium (GO:0016045)4.18128264
35antigen receptor-mediated signaling pathway (GO:0050851)4.17170797
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.15667402
37negative thymic T cell selection (GO:0045060)4.13393535
38negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.07197906
39immunoglobulin mediated immune response (GO:0016064)4.02850366
40regulation of B cell apoptotic process (GO:0002902)4.01926882
41positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.01154505
42thymic T cell selection (GO:0045061)3.92717678
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.92192024
44germinal center formation (GO:0002467)3.84399578
45B cell homeostasis (GO:0001782)3.83997067
46positive regulation of granulocyte differentiation (GO:0030854)3.83731946
47negative T cell selection (GO:0043383)3.82076842
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.80381992
49NIK/NF-kappaB signaling (GO:0038061)3.75574432
50immune response-activating cell surface receptor signaling pathway (GO:0002429)3.75490160
51positive regulation of B cell proliferation (GO:0030890)3.72606520
52positive regulation of interferon-alpha production (GO:0032727)3.70777161
53neutrophil activation involved in immune response (GO:0002283)3.69086459
54B cell activation (GO:0042113)3.67376687
55activated T cell proliferation (GO:0050798)3.64542626
56negative regulation of B cell apoptotic process (GO:0002903)3.64475403
57lymphocyte homeostasis (GO:0002260)3.60042541
58negative regulation of alpha-beta T cell activation (GO:0046636)3.59366267
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.59289518
60response to protozoan (GO:0001562)3.57955322
61T cell selection (GO:0045058)3.55283472
62regulation of interferon-alpha production (GO:0032647)3.55222890
63positive regulation of antigen processing and presentation (GO:0002579)3.54717026
64lymph node development (GO:0048535)3.54534421
65positive T cell selection (GO:0043368)3.54346604
66mature B cell differentiation involved in immune response (GO:0002313)3.52562438
67tolerance induction (GO:0002507)3.51292133
68interferon-gamma-mediated signaling pathway (GO:0060333)3.48581940
69regulation of alpha-beta T cell proliferation (GO:0046640)3.46947846
70antigen processing and presentation via MHC class Ib (GO:0002475)3.46009286
71negative regulation of T cell mediated immunity (GO:0002710)3.44698548
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.43573072
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43573072
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.42930901
75regulation of B cell activation (GO:0050864)3.41815675
76negative regulation of phagocytosis (GO:0050765)3.39124612
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.36170221
78respiratory burst (GO:0045730)3.35957825
79positive regulation of B cell activation (GO:0050871)3.35353014
80detection of external biotic stimulus (GO:0098581)3.34953713
81T cell migration (GO:0072678)3.33605270
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33029623
83cellular extravasation (GO:0045123)3.31739026
84T cell homeostasis (GO:0043029)3.26271443
85positive regulation of interleukin-2 production (GO:0032743)3.25326183
86leukocyte aggregation (GO:0070486)3.24813940
87positive regulation of Rap GTPase activity (GO:0032854)3.22961955
88negative regulation of leukocyte mediated immunity (GO:0002704)3.21670134
89lymphocyte proliferation (GO:0046651)3.21467794
90T cell costimulation (GO:0031295)3.20337229
91mononuclear cell proliferation (GO:0032943)3.19836845
92regulation of T-helper 2 cell differentiation (GO:0045628)3.19791622
93leukocyte homeostasis (GO:0001776)3.19499495
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18705336
95positive regulation of immunoglobulin production (GO:0002639)3.18074564
96B cell mediated immunity (GO:0019724)3.17163508
97negative regulation of cell killing (GO:0031342)3.17026393
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17026393
99lymphocyte costimulation (GO:0031294)3.13002382
100macrophage activation involved in immune response (GO:0002281)3.11546906
101positive regulation of type 2 immune response (GO:0002830)3.10803217
102regulation of interferon-gamma biosynthetic process (GO:0045072)3.10656459
103negative regulation of adaptive immune response (GO:0002820)3.09552046
104positive regulation by symbiont of host defense response (GO:0052509)3.06186870
105modulation by symbiont of host defense response (GO:0052031)3.06186870
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06186870
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06186870
108positive regulation by organism of defense response of other organism involved in symbiotic interact3.06186870
109modulation by symbiont of host immune response (GO:0052553)3.06186870
110immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.05010757
111Fc-gamma receptor signaling pathway (GO:0038094)3.05010757
112Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.05010757
113Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.01612706
114regulation of T cell receptor signaling pathway (GO:0050856)3.00372075
115myeloid cell activation involved in immune response (GO:0002275)2.99889557
116regulation of mast cell degranulation (GO:0043304)2.99421173
117regulation of tolerance induction (GO:0002643)2.98978029
118cellular response to type I interferon (GO:0071357)2.97719841
119type I interferon signaling pathway (GO:0060337)2.97719841
120response to type I interferon (GO:0034340)2.97516964
121interferon-gamma production (GO:0032609)2.97045257
122positive regulation of mast cell activation (GO:0033005)2.95927321
123negative regulation of alpha-beta T cell differentiation (GO:0046639)2.95875797
124regulation of mast cell activation (GO:0033003)2.95339282
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95316456
126B cell differentiation (GO:0030183)2.95137766
127regulation of antigen processing and presentation (GO:0002577)2.93687060
128immune response-activating signal transduction (GO:0002757)2.92642721
129regulation of T cell tolerance induction (GO:0002664)2.92565157
130regulation of granulocyte differentiation (GO:0030852)2.91713082
131B cell activation involved in immune response (GO:0002312)2.91611100
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90701572
133regulation of T-helper 1 cell differentiation (GO:0045625)2.89604314
134positive regulation of cytokine biosynthetic process (GO:0042108)2.88635040
135regulation of mast cell activation involved in immune response (GO:0033006)2.88518346
136phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88139473
137neutrophil activation (GO:0042119)2.87408077
138regulation of germinal center formation (GO:0002634)2.86324434
139mast cell activation (GO:0045576)2.86119898
140T cell receptor signaling pathway (GO:0050852)2.85762436
141leukocyte proliferation (GO:0070661)2.85599124
142microglial cell activation (GO:0001774)2.85372991
143histone H3-K36 demethylation (GO:0070544)2.84403861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.92259817
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78297431
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.63107549
4MYC_22102868_ChIP-Seq_BL_Human4.39426494
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.25728764
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.09790258
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41277330
8E2F7_22180533_ChIP-Seq_HELA_Human3.36222461
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31148651
10VDR_21846776_ChIP-Seq_THP-1_Human3.14309501
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.12697915
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.91253733
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.75488752
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.75122414
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57552641
16RUNX_20019798_ChIP-Seq_JUKART_Human2.53149180
17MYB_26560356_Chip-Seq_TH2_Human2.52655233
18MAF_26560356_Chip-Seq_TH1_Human2.51185318
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47096979
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37485116
21* MYB_26560356_Chip-Seq_TH1_Human2.36662134
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31440282
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28336369
24SPI1_23547873_ChIP-Seq_NB4_Human2.26822439
25VDR_24763502_ChIP-Seq_THP-1_Human2.23424514
26UTX_26944678_Chip-Seq_JUKART_Human2.23323198
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22216291
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21366732
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18914668
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.10809287
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07496726
32SCL_19346495_ChIP-Seq_HPC-7_Human2.07364888
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97039146
34CIITA_25753668_ChIP-Seq_RAJI_Human1.96195576
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94733652
36TCF7_22412390_ChIP-Seq_EML_Mouse1.88578093
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88295263
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87073618
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.84298545
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83632419
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.81527283
42VDR_24787735_ChIP-Seq_THP-1_Human1.78068411
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.74500848
44MAF_26560356_Chip-Seq_TH2_Human1.71863374
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69788098
46SPI1_23127762_ChIP-Seq_K562_Human1.68289110
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63936900
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60041015
49GATA3_27048872_Chip-Seq_THYMUS_Human1.58874660
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56239656
51KDM2B_26808549_Chip-Seq_DND41_Human1.53666561
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49011556
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46838695
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46123522
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45679614
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41211500
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36322853
58GATA1_22025678_ChIP-Seq_K562_Human1.34225328
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31646510
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29993775
61SMRT_27268052_Chip-Seq_Bcells_Human1.27407350
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27137911
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.26613389
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25336499
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24673394
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24325906
67PU_27001747_Chip-Seq_BMDM_Mouse1.22860509
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22194500
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21701563
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19259415
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15243872
72FOXP3_21729870_ChIP-Seq_TREG_Human1.14321009
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13895683
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13760280
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13747000
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12083472
77GATA3_26560356_Chip-Seq_TH2_Human1.09824924
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08183973
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08055061
80VDR_23849224_ChIP-Seq_CD4+_Human1.07479101
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03525101
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99494654
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99445619
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97902962
85KDM5A_27292631_Chip-Seq_BREAST_Human0.96441916
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96095662
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95858758
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94729290
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94569340
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.90045483
91EZH2_22144423_ChIP-Seq_EOC_Human0.89369736
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88705083
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87412703
94P300_27268052_Chip-Seq_Bcells_Human0.84276958
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.83745702
96LXR_22292898_ChIP-Seq_THP-1_Human0.83414828
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83382746
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82581817
99BCL6_27268052_Chip-Seq_Bcells_Human0.81787334
100NCOR1_26117541_ChIP-Seq_K562_Human0.81753272
101GATA1_19941826_ChIP-Seq_K562_Human0.81308150
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81273986
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80956717
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.79974816
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79333592
106BCAT_22108803_ChIP-Seq_LS180_Human0.78489818
107SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78110355
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.77638731
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77320747
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77276191
111TFEB_21752829_ChIP-Seq_HELA_Human0.76300048
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75882928
113GATA3_26560356_Chip-Seq_TH1_Human0.74132528
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.73536825
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73457927
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73246839
117XRN2_22483619_ChIP-Seq_HELA_Human0.73188097
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72401436
119FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.71456498
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68104585
121GATA2_19941826_ChIP-Seq_K562_Human0.66747362
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65899958
123BCOR_27268052_Chip-Seq_Bcells_Human0.65825956
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.64465891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.91422097
2MP0001800_abnormal_humoral_immune4.81765806
3MP0005387_immune_system_phenotype4.77883802
4MP0001790_abnormal_immune_system4.77883802
5MP0000685_abnormal_immune_system4.01812163
6MP0002452_abnormal_antigen_presenting3.73762616
7MP0003303_peritoneal_inflammation3.44658032
8MP0005000_abnormal_immune_tolerance3.43227808
9MP0005671_abnormal_response_to3.39147855
10MP0003724_increased_susceptibility_to3.28515593
11MP0002723_abnormal_immune_serum3.23476534
12MP0002420_abnormal_adaptive_immunity3.13041870
13MP0001819_abnormal_immune_cell3.03769255
14MP0002398_abnormal_bone_marrow2.86894059
15MP0000716_abnormal_immune_system2.65531834
16MP0000689_abnormal_spleen_morphology2.61413478
17MP0003763_abnormal_thymus_physiology2.61055602
18MP0005025_abnormal_response_to2.34292068
19MP0002148_abnormal_hypersensitivity_rea2.26626680
20MP0009785_altered_susceptibility_to2.21427003
21MP0002419_abnormal_innate_immunity2.21134663
22MP0002429_abnormal_blood_cell2.18870205
23MP0002722_abnormal_immune_system2.16957631
24MP0002396_abnormal_hematopoietic_system2.15973445
25MP0003436_decreased_susceptibility_to2.08602820
26MP0002166_altered_tumor_susceptibility2.03030959
27MP0001873_stomach_inflammation2.01200889
28MP0003300_gastrointestinal_ulcer2.00675576
29MP0002405_respiratory_system_inflammati2.00049332
30MP0003787_abnormal_imprinting1.96797860
31MP0004510_myositis1.95616264
32MP0001853_heart_inflammation1.92543989
33MP0001845_abnormal_inflammatory_respons1.80828850
34MP0004381_abnormal_hair_follicle1.74123154
35MP0003183_abnormal_peptide_metabolism1.68633841
36MP0010155_abnormal_intestine_physiology1.64352579
37MP0009333_abnormal_splenocyte_physiolog1.61860713
38MP0002009_preneoplasia1.55274856
39MP0004947_skin_inflammation1.53013549
40MP0005464_abnormal_platelet_physiology1.52432919
41MP0004808_abnormal_hematopoietic_stem1.52208393
42MP0000703_abnormal_thymus_morphology1.51466538
43MP0002933_joint_inflammation1.50125369
44MP0005310_abnormal_salivary_gland1.45457224
45MP0008057_abnormal_DNA_replication1.41324565
46MP0002006_tumorigenesis1.40279135
47MP0003866_abnormal_defecation1.39705433
48MP0004883_abnormal_blood_vessel1.37342232
49MP0001986_abnormal_taste_sensitivity1.36760848
50MP0000465_gastrointestinal_hemorrhage1.28829911
51MP0006082_CNS_inflammation1.19450711
52MP0008469_abnormal_protein_level1.15197040
53MP0002132_abnormal_respiratory_system1.11438435
54MP0005174_abnormal_tail_pigmentation1.08228888
55MP0001851_eye_inflammation1.04759465
56MP0002019_abnormal_tumor_incidence1.03868946
57MP0003191_abnormal_cellular_cholesterol1.02718896
58MP0010234_abnormal_vibrissa_follicle1.01551076
59MP0008877_abnormal_DNA_methylation0.99000897
60MP0003077_abnormal_cell_cycle0.97099497
61MP0002136_abnormal_kidney_physiology0.91932629
62MP0005451_abnormal_body_composition0.91043308
63MP0010094_abnormal_chromosome_stability0.89847612
64MP0003172_abnormal_lysosome_physiology0.85550011
65MP0003091_abnormal_cell_migration0.81874473
66MP0010352_gastrointestinal_tract_polyps0.81219298
67MP0000569_abnormal_digit_pigmentation0.80193641
68MP0003045_fibrosis0.78364298
69MP0009278_abnormal_bone_marrow0.78053370
70MP0002928_abnormal_bile_duct0.77047136
71MP0000490_abnormal_crypts_of0.75858045
72MP0005397_hematopoietic_system_phenotyp0.74547278
73MP0001545_abnormal_hematopoietic_system0.74547278
74MP0003656_abnormal_erythrocyte_physiolo0.74222870
75MP0001533_abnormal_skeleton_physiology0.74084467
76MP0005058_abnormal_lysosome_morphology0.72475859
77MP0000015_abnormal_ear_pigmentation0.72325315
78MP0009764_decreased_sensitivity_to0.69869049
79MP0003693_abnormal_embryo_hatching0.69553697
80MP0004484_altered_response_of0.67036729
81MP0005164_abnormal_response_to0.64970836
82MP0002095_abnormal_skin_pigmentation0.64652159
83MP0008004_abnormal_stomach_pH0.61056217
84MP0003690_abnormal_glial_cell0.60466537
85MP0008961_abnormal_basal_metabolism0.60233401
86MP0005166_decreased_susceptibility_to0.60215820
87MP0003566_abnormal_cell_adhesion0.60078370
88MP0001879_abnormal_lymphatic_vessel0.59953003
89MP0000249_abnormal_blood_vessel0.59822541
90MP0008874_decreased_physiological_sensi0.59716356
91MP0002909_abnormal_adrenal_gland0.59366472
92MP0005076_abnormal_cell_differentiation0.59073523
93MP0002998_abnormal_bone_remodeling0.56733837
94MP0004130_abnormal_muscle_cell0.56389281
95MP0005621_abnormal_cell_physiology0.55919347
96MP0001663_abnormal_digestive_system0.55438752
97MP0000350_abnormal_cell_proliferation0.55088171
98MP0000313_abnormal_cell_death0.54673191
99MP0003448_altered_tumor_morphology0.54225323
100MP0000858_altered_metastatic_potential0.54017420
101MP0005381_digestive/alimentary_phenotyp0.53518432
102MP0000372_irregular_coat_pigmentation0.52543865
103MP0000767_abnormal_smooth_muscle0.52310009
104MP0003221_abnormal_cardiomyocyte_apopto0.52072742
105MP0002138_abnormal_hepatobiliary_system0.51703111
106MP0006054_spinal_hemorrhage0.51418121
107MP0003252_abnormal_bile_duct0.50880931
108MP0005584_abnormal_enzyme/coenzyme_acti0.50236180
109MP0009763_increased_sensitivity_to0.49729108
110MP0005023_abnormal_wound_healing0.48111688
111MP0003111_abnormal_nucleus_morphology0.47836627
112MP0008058_abnormal_DNA_repair0.47830657
113MP0000609_abnormal_liver_physiology0.47608802
114MP0001348_abnormal_lacrimal_gland0.47271497
115MP0008260_abnormal_autophagy0.46524363
116MP0005075_abnormal_melanosome_morpholog0.46441144
117MP0005376_homeostasis/metabolism_phenot0.46156742
118MP0003828_pulmonary_edema0.46018929
119MP0003453_abnormal_keratinocyte_physiol0.45642689
120MP0000371_diluted_coat_color0.44945589
121MP0010307_abnormal_tumor_latency0.44319592
122MP0004957_abnormal_blastocyst_morpholog0.43317792
123MP0009765_abnormal_xenobiotic_induced0.42707125
124MP0002693_abnormal_pancreas_physiology0.42527668
125MP0002277_abnormal_respiratory_mucosa0.42084917

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)8.91070240
2Gastrointestinal stroma tumor (HP:0100723)7.98311077
3Recurrent bronchitis (HP:0002837)6.67569648
4Recurrent sinusitis (HP:0011108)6.17867812
5Colitis (HP:0002583)5.92727265
6Cellulitis (HP:0100658)5.71418953
7IgM deficiency (HP:0002850)5.54996111
8Lymphopenia (HP:0001888)5.13501120
9Inflammation of the large intestine (HP:0002037)5.10048490
10Emphysema (HP:0002097)5.00351958
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.95964004
12Abnormality of cells of the lymphoid lineage (HP:0012140)4.93932896
13Gastrointestinal inflammation (HP:0004386)4.89634167
14Verrucae (HP:0200043)4.76792355
15Papilloma (HP:0012740)4.76792355
16Recurrent viral infections (HP:0004429)4.74061054
17Panhypogammaglobulinemia (HP:0003139)4.62170193
18IgA deficiency (HP:0002720)4.56713019
19Meningitis (HP:0001287)4.49826341
20Chronic sinusitis (HP:0011109)4.48842728
21Recurrent abscess formation (HP:0002722)4.34656484
22Vasculitis (HP:0002633)4.32941233
23Chronic otitis media (HP:0000389)4.27456066
24Recurrent bacterial skin infections (HP:0005406)4.08624396
25Recurrent lower respiratory tract infections (HP:0002783)4.00950059
26Recurrent pneumonia (HP:0006532)3.90106975
27Bronchitis (HP:0012387)3.87244909
28Restrictive lung disease (HP:0002091)3.85705414
29Recurrent cutaneous fungal infections (HP:0011370)3.77137148
30Chronic mucocutaneous candidiasis (HP:0002728)3.77137148
31Osteomyelitis (HP:0002754)3.71299981
32Recurrent fungal infections (HP:0002841)3.67896048
33Retrobulbar optic neuritis (HP:0100654)3.62503572
34Optic neuritis (HP:0100653)3.62503572
35Recurrent otitis media (HP:0000403)3.54482802
36Gastrointestinal infarctions (HP:0005244)3.46608521
37Mediastinal lymphadenopathy (HP:0100721)3.43590045
38Eczematoid dermatitis (HP:0000976)3.41019267
39Chronic diarrhea (HP:0002028)3.39025026
40IgG deficiency (HP:0004315)3.38095918
41Orchitis (HP:0100796)3.36762965
42Recurrent skin infections (HP:0001581)3.33774345
43Abnormality of T cell physiology (HP:0011840)3.26785973
44Autoimmune thrombocytopenia (HP:0001973)3.21318521
45Prolonged bleeding time (HP:0003010)3.14926606
46Abnormality of T cells (HP:0002843)3.07490155
47Abnormality of B cell number (HP:0010975)3.06856026
48B lymphocytopenia (HP:0010976)3.06856026
49Small epiphyses (HP:0010585)2.98898510
50Sepsis (HP:0100806)2.95284707
51Leukopenia (HP:0001882)2.95180977
52Abnormality of the fingertips (HP:0001211)2.93749452
53Lymphoma (HP:0002665)2.92567895
54Viral hepatitis (HP:0006562)2.90093164
55Thyroiditis (HP:0100646)2.83749573
56Thrombocytosis (HP:0001894)2.72165927
57Abnormality of T cell number (HP:0011839)2.63385694
58Leukocytosis (HP:0001974)2.62135904
59Hemoptysis (HP:0002105)2.60994326
60Keratoconjunctivitis sicca (HP:0001097)2.60048933
61Nasal polyposis (HP:0100582)2.57932419
62T lymphocytopenia (HP:0005403)2.57129575
63Interstitial pulmonary disease (HP:0006530)2.56191658
64Mitral stenosis (HP:0001718)2.55914510
65Abnormality of the prostate (HP:0008775)2.54115648
66Epistaxis (HP:0000421)2.53597526
67Chronic obstructive pulmonary disease (HP:0006510)2.53526315
68Obstructive lung disease (HP:0006536)2.53526315
69Keratoconjunctivitis (HP:0001096)2.51299243
70Gingival bleeding (HP:0000225)2.44781104
71Pustule (HP:0200039)2.44781099
72Recurrent gram-negative bacterial infections (HP:0005420)2.43174541
73Hypoplasia of the thymus (HP:0000778)2.42459170
74Encephalitis (HP:0002383)2.42189223
75Severe combined immunodeficiency (HP:0004430)2.41313633
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40618663
77Pulmonary infiltrates (HP:0002113)2.38760605
78Elevated erythrocyte sedimentation rate (HP:0003565)2.34418002
79Skin ulcer (HP:0200042)2.31124071
80Skin rash (HP:0000988)2.30281950
81Pulmonary embolism (HP:0002204)2.26015665
82Abnormality of eosinophils (HP:0001879)2.25296317
83Abnormality of the pleura (HP:0002103)2.23157839
84Arthralgia (HP:0002829)2.22634835
85Spontaneous hematomas (HP:0007420)2.18612497
86Increased IgE level (HP:0003212)2.16257456
87Hypochromic microcytic anemia (HP:0004840)2.15104419
88Abnormality of the nasal mucosa (HP:0000433)2.13429546
89Hypochromic anemia (HP:0001931)2.09635852
90Stomach cancer (HP:0012126)2.08398741
91Hematochezia (HP:0002573)2.08220848
92Neutropenia (HP:0001875)2.07308499
93Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05047438
94Arterial thrombosis (HP:0004420)2.03236745
95Myositis (HP:0100614)2.00732712
96Fatigue (HP:0012378)1.99948168
97Vertebral arch anomaly (HP:0008438)1.98554281
98Abnormality of macrophages (HP:0004311)1.96700305
99Papilledema (HP:0001085)1.94630863
100Increased IgM level (HP:0003496)1.93004786
101Villous atrophy (HP:0011473)1.91690630
102Abnormality of small intestinal villus morphology (HP:0011472)1.91690630
103Anorexia (HP:0002039)1.91372800
104Gangrene (HP:0100758)1.88227229
105Microcytic anemia (HP:0001935)1.86979124
106Xerostomia (HP:0000217)1.86310964
107Flattened epiphyses (HP:0003071)1.85787172
108Gingivitis (HP:0000230)1.85665273
109Stomatitis (HP:0010280)1.81304846
110Episodic fever (HP:0001954)1.81217405
111Hepatitis (HP:0012115)1.80924319
112Combined immunodeficiency (HP:0005387)1.78265495
113Acrocyanosis (HP:0001063)1.75003194
114Irregular vertebral endplates (HP:0003301)1.73466934
115Periodontitis (HP:0000704)1.72742306
116Chest pain (HP:0100749)1.70539233
117Eosinophilia (HP:0001880)1.67987311
118Basal cell carcinoma (HP:0002671)1.66956968
119Urticaria (HP:0001025)1.62725689
120Absent epiphyses (HP:0010577)1.58573815
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58573815
122Myocardial infarction (HP:0001658)1.57969610
123Mucosal telangiectasiae (HP:0100579)1.57755288
124Granulocytopenia (HP:0001913)1.55467795
125Petechiae (HP:0000967)1.54343380
126Hypergammaglobulinemia (HP:0010702)1.53555037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.42279238
2CSF1R3.48842583
3BLK3.27888767
4GRK62.88930337
5ERN12.88204712
6SYK2.74464613
7BTK2.60816598
8MAP3K132.58957019
9RIPK42.42150657
10KIT2.32287527
11MAP3K142.30531048
12STK102.25140366
13LRRK22.23085387
14MAP3K102.22292455
15TYK22.15532694
16BMPR21.97012369
17JAK11.91611922
18PRPF4B1.90648235
19LYN1.73473991
20TBK11.69321402
21SIK21.62352730
22JAK31.52609856
23IRAK41.51734928
24TEC1.51203958
25HCK1.50217441
26ZAP701.49808918
27CSK1.48040871
28IKBKB1.47739646
29ITK1.46564227
30IRAK31.42775432
31TGFBR21.37325661
32GRK11.29547247
33MST41.27985840
34CDK121.23160373
35LCK1.20512321
36PRKCQ1.19635415
37IKBKE1.19519093
38CDK191.17643162
39PRKCH1.14325200
40FES1.14042345
41CLK11.13442042
42FRK1.12304115
43MARK31.12110921
44EIF2AK31.07902356
45MARK21.04601834
46SIK31.03685470
47EEF2K1.02814501
48RPS6KA41.01071548
49IRAK10.98804853
50FLT30.92277255
51IRAK20.90457909
52FGFR40.86135971
53MATK0.86121556
54PIM10.85075539
55MAP2K30.83154794
56FGFR30.80720159
57PIK3CG0.80247984
58BRD40.78746159
59CHUK0.78739481
60YES10.77632389
61ALK0.75305977
62TAOK10.75050022
63TNK20.66301854
64CAMKK20.66225470
65FGR0.62909335
66MAP3K10.61852873
67CDC42BPA0.60723657
68MAP3K90.59516125
69TRIB30.58814542
70STK110.57818369
71ACVR1B0.56535504
72PDK10.56316264
73SGK20.55918184
74MAPK70.55765603
75DYRK1B0.55742550
76NEK20.54938096
77ABL10.54596193
78MAP3K30.52939109
79TXK0.52272472
80CCNB10.51898539
81SIK10.51660608
82PTK2B0.51438004
83EPHB10.48978642
84HIPK20.48942644
85MAPK120.47592129
86PDPK10.46973572
87KDR0.46768144
88SGK30.46089760
89PKN20.46081544
90CSNK1A1L0.45914567
91CAMKK10.45196631
92CDK40.44976606
93PRKCI0.43967145
94FYN0.43614840
95INSR0.43246460
96TESK20.42319794
97KSR20.41045640
98MAP3K70.40595237
99MELK0.40070016
100PRKD20.39459723
101PRKCD0.37564627
102NLK0.36976934
103EGFR0.36611909
104MAP3K20.36571989
105JAK20.36570092
106STK40.36185649
107MAP2K20.34873856
108NTRK20.33911358
109CAMK1D0.33806968
110CDK60.33677514
111SCYL20.33459301
112MAP3K80.31810163
113MAP3K110.30771091
114CAMK1G0.29908524
115DYRK1A0.29499558
116CAMK40.29079394
117PASK0.27093849
118CSNK1G30.26629780
119CSNK1G10.26589106
120MAPKAPK20.25964051
121NEK90.25846811
122PRKD10.25660389
123MAPK110.24617434
124CDK90.23519790
125RIPK10.23302232
126PTK60.23146147
127PRKCZ0.22676846
128MAPK40.21631716
129TLK10.20777802
130EIF2AK10.19873287
131RAF10.19727086
132TAOK30.17425720

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.19005532
2B cell receptor signaling pathway_Homo sapiens_hsa046625.76746262
3Hematopoietic cell lineage_Homo sapiens_hsa046403.12695208
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.98765809
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.97093059
6Antigen processing and presentation_Homo sapiens_hsa046122.52576544
7Osteoclast differentiation_Homo sapiens_hsa043802.25791132
8Leishmaniasis_Homo sapiens_hsa051402.23380498
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.11382778
10T cell receptor signaling pathway_Homo sapiens_hsa046601.97177923
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85944170
12Base excision repair_Homo sapiens_hsa034101.85879757
13Measles_Homo sapiens_hsa051621.73641236
14Herpes simplex infection_Homo sapiens_hsa051681.63544373
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62938646
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62131928
17Tuberculosis_Homo sapiens_hsa051521.52424426
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49902920
19Mismatch repair_Homo sapiens_hsa034301.48685172
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46909556
21Chemokine signaling pathway_Homo sapiens_hsa040621.45732193
22DNA replication_Homo sapiens_hsa030301.41133483
23Epstein-Barr virus infection_Homo sapiens_hsa051691.32150169
24Allograft rejection_Homo sapiens_hsa053301.31837281
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29369825
26Shigellosis_Homo sapiens_hsa051311.28508044
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.27470571
28Non-homologous end-joining_Homo sapiens_hsa034501.25387780
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.19951889
30Ribosome_Homo sapiens_hsa030101.19096812
31Toxoplasmosis_Homo sapiens_hsa051451.18800694
32Influenza A_Homo sapiens_hsa051641.18642926
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18018452
34Viral myocarditis_Homo sapiens_hsa054161.16571743
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12342453
36Hepatitis B_Homo sapiens_hsa051611.10993943
37Rheumatoid arthritis_Homo sapiens_hsa053231.10366132
38Apoptosis_Homo sapiens_hsa042101.07760318
39African trypanosomiasis_Homo sapiens_hsa051431.02493393
40Platelet activation_Homo sapiens_hsa046111.01198309
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99131471
42Acute myeloid leukemia_Homo sapiens_hsa052210.96614115
43Malaria_Homo sapiens_hsa051440.95333287
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.94386322
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90416525
46Non-small cell lung cancer_Homo sapiens_hsa052230.90304306
47Pancreatic cancer_Homo sapiens_hsa052120.89977186
48Legionellosis_Homo sapiens_hsa051340.89596141
49Pertussis_Homo sapiens_hsa051330.89403645
50Phagosome_Homo sapiens_hsa041450.87490599
51Chronic myeloid leukemia_Homo sapiens_hsa052200.87202261
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84961321
53TNF signaling pathway_Homo sapiens_hsa046680.84638027
54Viral carcinogenesis_Homo sapiens_hsa052030.81939124
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81732074
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76333501
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.76107604
58Other glycan degradation_Homo sapiens_hsa005110.75218598
59HTLV-I infection_Homo sapiens_hsa051660.74924007
60Staphylococcus aureus infection_Homo sapiens_hsa051500.72519752
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71973264
62Choline metabolism in cancer_Homo sapiens_hsa052310.71822063
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70921090
64Homologous recombination_Homo sapiens_hsa034400.67937583
65Spliceosome_Homo sapiens_hsa030400.67388772
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66319715
67Salmonella infection_Homo sapiens_hsa051320.65412911
68Hepatitis C_Homo sapiens_hsa051600.65132671
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64730111
70Asthma_Homo sapiens_hsa053100.63724285
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62323974
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.61259067
73VEGF signaling pathway_Homo sapiens_hsa043700.60615467
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60008691
75Graft-versus-host disease_Homo sapiens_hsa053320.59919484
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56155491
77Type I diabetes mellitus_Homo sapiens_hsa049400.54712778
78Nucleotide excision repair_Homo sapiens_hsa034200.54331619
79Regulation of autophagy_Homo sapiens_hsa041400.52425493
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.50514267
81p53 signaling pathway_Homo sapiens_hsa041150.48398688
82Autoimmune thyroid disease_Homo sapiens_hsa053200.48121957
83Small cell lung cancer_Homo sapiens_hsa052220.47555075
84Notch signaling pathway_Homo sapiens_hsa043300.47532831
85MAPK signaling pathway_Homo sapiens_hsa040100.46449949
86Endocytosis_Homo sapiens_hsa041440.45252730
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42587670
88Endometrial cancer_Homo sapiens_hsa052130.41851414
89Lysosome_Homo sapiens_hsa041420.40916408
90GnRH signaling pathway_Homo sapiens_hsa049120.40902804
91ABC transporters_Homo sapiens_hsa020100.39923607
92Inositol phosphate metabolism_Homo sapiens_hsa005620.39364863
93Colorectal cancer_Homo sapiens_hsa052100.37574972
94Insulin resistance_Homo sapiens_hsa049310.36139481
95MicroRNAs in cancer_Homo sapiens_hsa052060.36093823
96Long-term potentiation_Homo sapiens_hsa047200.35784141
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35358184
98FoxO signaling pathway_Homo sapiens_hsa040680.30873394
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.29977278
100Ras signaling pathway_Homo sapiens_hsa040140.29853738
101Prolactin signaling pathway_Homo sapiens_hsa049170.29217328
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27434455
103Proteoglycans in cancer_Homo sapiens_hsa052050.27132665
104Olfactory transduction_Homo sapiens_hsa047400.27132021
105Long-term depression_Homo sapiens_hsa047300.26933142
106Systemic lupus erythematosus_Homo sapiens_hsa053220.25936395
107Lysine degradation_Homo sapiens_hsa003100.25788300
108Cholinergic synapse_Homo sapiens_hsa047250.24841312
109Type II diabetes mellitus_Homo sapiens_hsa049300.24638349
110mTOR signaling pathway_Homo sapiens_hsa041500.23394922
111Renal cell carcinoma_Homo sapiens_hsa052110.23033663
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23006999
113ErbB signaling pathway_Homo sapiens_hsa040120.22582521
114RNA degradation_Homo sapiens_hsa030180.22176466
115Morphine addiction_Homo sapiens_hsa050320.21334410
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.20910459
117Rap1 signaling pathway_Homo sapiens_hsa040150.20584817
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20513626
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19568742
120Caffeine metabolism_Homo sapiens_hsa002320.19496404
121Ether lipid metabolism_Homo sapiens_hsa005650.19276204
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19090613
123Pentose phosphate pathway_Homo sapiens_hsa000300.18520369
124Prostate cancer_Homo sapiens_hsa052150.18476314
125HIF-1 signaling pathway_Homo sapiens_hsa040660.18453879
126mRNA surveillance pathway_Homo sapiens_hsa030150.17150189

Most similar genes based on co-expression Upload to Enrichr

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