FCRL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)5.93345445
2regulation of B cell receptor signaling pathway (GO:0050855)5.24308369
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.15519883
4positive regulation of gamma-delta T cell activation (GO:0046645)4.55774743
5antigen processing and presentation of endogenous antigen (GO:0019883)4.31366214
6regulation of B cell differentiation (GO:0045577)4.29054416
7positive thymic T cell selection (GO:0045059)3.94006149
8positive regulation of B cell differentiation (GO:0045579)3.86801321
9regulation of antigen processing and presentation (GO:0002577)3.81981409
10B cell proliferation (GO:0042100)3.80224727
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79828670
12defense response to protozoan (GO:0042832)3.77317435
13regulation of interferon-beta biosynthetic process (GO:0045357)3.75485357
14positive T cell selection (GO:0043368)3.72874005
15negative regulation of cell killing (GO:0031342)3.63701160
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63701160
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63530537
18production of molecular mediator involved in inflammatory response (GO:0002532)3.56184673
19L-fucose metabolic process (GO:0042354)3.54320612
20L-fucose catabolic process (GO:0042355)3.54320612
21fucose catabolic process (GO:0019317)3.54320612
22negative regulation of calcium ion transport into cytosol (GO:0010523)3.52791292
23negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.52589817
24negative regulation of T-helper cell differentiation (GO:0045623)3.52589817
25DNA deamination (GO:0045006)3.51414467
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44995710
27immunoglobulin mediated immune response (GO:0016064)3.41856019
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39390943
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33397469
30behavioral response to nicotine (GO:0035095)3.32333089
31regulation of gamma-delta T cell activation (GO:0046643)3.31146431
32positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.28419985
33regulation of gamma-delta T cell differentiation (GO:0045586)3.19133894
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18828890
35macrophage activation involved in immune response (GO:0002281)3.18628815
36response to protozoan (GO:0001562)3.17408495
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17100325
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.16307118
39antigen receptor-mediated signaling pathway (GO:0050851)3.15323715
40T cell selection (GO:0045058)3.13023004
41negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.11384163
42negative regulation of mast cell activation (GO:0033004)3.05677196
43cellular response to interleukin-15 (GO:0071350)3.05141497
44positive regulation of defense response to virus by host (GO:0002230)3.04658543
45positive regulation of antigen processing and presentation (GO:0002579)3.04476196
46regulation of germinal center formation (GO:0002634)3.04387002
47negative T cell selection (GO:0043383)3.04239605
48negative thymic T cell selection (GO:0045060)3.03704404
49positive regulation of granulocyte differentiation (GO:0030854)3.03413906
50regulation of B cell proliferation (GO:0030888)2.95001902
51regulation of MHC class I biosynthetic process (GO:0045343)2.94056419
52activated T cell proliferation (GO:0050798)2.93667494
53negative regulation of alpha-beta T cell activation (GO:0046636)2.91919279
54indolalkylamine metabolic process (GO:0006586)2.89135163
55B cell activation (GO:0042113)2.88096643
56negative regulation of T cell differentiation (GO:0045581)2.87356814
57negative regulation of B cell proliferation (GO:0030889)2.86014676
58B cell homeostasis (GO:0001782)2.84673708
59response to pheromone (GO:0019236)2.84634821
60regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82544486
61CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80686753
62indole-containing compound catabolic process (GO:0042436)2.78921062
63indolalkylamine catabolic process (GO:0046218)2.78921062
64tryptophan catabolic process (GO:0006569)2.78921062
65pyrimidine ribonucleoside catabolic process (GO:0046133)2.76533834
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75429429
67negative regulation of alpha-beta T cell differentiation (GO:0046639)2.75303664
68regulation of interferon-gamma biosynthetic process (GO:0045072)2.74912755
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73049250
70response to interleukin-15 (GO:0070672)2.70854802
71neural tube formation (GO:0001841)2.67434040
72regulation of T cell receptor signaling pathway (GO:0050856)2.66662207
73positive regulation of B cell proliferation (GO:0030890)2.65450000
74thymic T cell selection (GO:0045061)2.63616133
75microglial cell activation (GO:0001774)2.62751404
76NIK/NF-kappaB signaling (GO:0038061)2.62231492
77positive regulation of calcium-mediated signaling (GO:0050850)2.62070502
78B cell mediated immunity (GO:0019724)2.59670603
79interferon-gamma-mediated signaling pathway (GO:0060333)2.59627724
80regulation of alpha-beta T cell proliferation (GO:0046640)2.58852521
81negative regulation of telomere maintenance (GO:0032205)2.58695149
82cytidine deamination (GO:0009972)2.57458750
83cytidine metabolic process (GO:0046087)2.57458750
84cytidine catabolic process (GO:0006216)2.57458750
85regulation of MHC class II biosynthetic process (GO:0045346)2.57163269
86positive regulation of B cell activation (GO:0050871)2.55494798
87regulation of T cell mediated cytotoxicity (GO:0001914)2.53248609
88negative regulation of adaptive immune response (GO:0002820)2.50624695
89positive regulation of interleukin-1 beta secretion (GO:0050718)2.50443029
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.49174527
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48825249
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.48825249
93modulation by symbiont of host immune response (GO:0052553)2.48825249
94positive regulation by symbiont of host defense response (GO:0052509)2.48825249
95modulation by symbiont of host defense response (GO:0052031)2.48825249
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48825249
97detection of bacterium (GO:0016045)2.48040497
98regulation of defense response to virus by host (GO:0050691)2.47845182
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46272030
100positive regulation of Rap GTPase activity (GO:0032854)2.45607262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.21515582
2ZNF274_21170338_ChIP-Seq_K562_Hela3.32289881
3EZH2_22144423_ChIP-Seq_EOC_Human3.18826818
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89903976
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66675011
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65025785
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.61558143
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60298922
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26727256
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10387279
11VDR_22108803_ChIP-Seq_LS180_Human2.03768496
12RUNX_20019798_ChIP-Seq_JUKART_Human2.01349157
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.00722983
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99803196
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.88888116
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86110838
17IGF1R_20145208_ChIP-Seq_DFB_Human1.82887512
18CIITA_25753668_ChIP-Seq_RAJI_Human1.73992763
19MYB_26560356_Chip-Seq_TH2_Human1.63743969
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63016905
21GATA3_26560356_Chip-Seq_TH2_Human1.60655130
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60514523
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55356320
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52165013
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51584839
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49690714
27ER_23166858_ChIP-Seq_MCF-7_Human1.48843247
28BCAT_22108803_ChIP-Seq_LS180_Human1.47686121
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46036923
30TAF15_26573619_Chip-Seq_HEK293_Human1.40802477
31SMRT_27268052_Chip-Seq_Bcells_Human1.40706937
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39859713
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.37776287
34GBX2_23144817_ChIP-Seq_PC3_Human1.32100692
35TP53_22573176_ChIP-Seq_HFKS_Human1.30444130
36EWS_26573619_Chip-Seq_HEK293_Human1.29703502
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29171384
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28433194
39P300_19829295_ChIP-Seq_ESCs_Human1.27522226
40FUS_26573619_Chip-Seq_HEK293_Human1.27211785
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27140698
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27056564
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26557046
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26437065
45GATA3_27048872_Chip-Seq_THYMUS_Human1.26072053
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25203726
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25203726
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.19377747
49MYB_26560356_Chip-Seq_TH1_Human1.17881696
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.17859670
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16878181
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16789661
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15126751
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13782836
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13566146
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.13072158
57TCF4_23295773_ChIP-Seq_U87_Human1.12800839
58IRF1_19129219_ChIP-ChIP_H3396_Human1.11716995
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.11671262
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11307065
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.11307065
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10971005
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10953401
64CBP_20019798_ChIP-Seq_JUKART_Human1.10953401
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10037599
66* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09117515
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08958443
68* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08928914
69STAT3_23295773_ChIP-Seq_U87_Human1.07038953
70VDR_23849224_ChIP-Seq_CD4+_Human1.06992039
71VDR_24787735_ChIP-Seq_THP-1_Human1.06286615
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05676766
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05530092
74AR_25329375_ChIP-Seq_VCAP_Human1.05132185
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.01999901
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01848347
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01039682
78* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00847282
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00452101
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98434427
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.98062924
82SPI1_23547873_ChIP-Seq_NB4_Human0.97864511
83* GATA3_26560356_Chip-Seq_TH1_Human0.95962709
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95847224
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94109686
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93922582
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93381808
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93156127
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.91146617
90REST_21632747_ChIP-Seq_MESCs_Mouse0.90677317
91NANOG_19829295_ChIP-Seq_ESCs_Human0.89953913
92SOX2_19829295_ChIP-Seq_ESCs_Human0.89953913
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89838262
94TCF4_22108803_ChIP-Seq_LS180_Human0.88232187
95TAF2_19829295_ChIP-Seq_ESCs_Human0.87788700
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87350876
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87345363
98NCOR_22424771_ChIP-Seq_293T_Human0.87175835
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86941402
100ERA_21632823_ChIP-Seq_H3396_Human0.86778988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.88049509
2MP0002138_abnormal_hepatobiliary_system3.55921299
3MP0001800_abnormal_humoral_immune3.54458903
4MP0001790_abnormal_immune_system3.39040379
5MP0005387_immune_system_phenotype3.39040379
6MP0005671_abnormal_response_to3.08165217
7MP0003787_abnormal_imprinting2.91751497
8MP0000685_abnormal_immune_system2.79054458
9MP0008877_abnormal_DNA_methylation2.66453463
10MP0001986_abnormal_taste_sensitivity2.51755301
11MP0002452_abnormal_antigen_presenting2.47311744
12MP0002723_abnormal_immune_serum2.39395930
13MP0000569_abnormal_digit_pigmentation2.31337954
14MP0005000_abnormal_immune_tolerance2.30522586
15MP0003763_abnormal_thymus_physiology2.24750828
16MP0002420_abnormal_adaptive_immunity2.23580309
17MP0001819_abnormal_immune_cell2.18267881
18MP0005075_abnormal_melanosome_morpholog2.03988171
19MP0001873_stomach_inflammation1.97235839
20MP0005310_abnormal_salivary_gland1.94515269
21MP0003183_abnormal_peptide_metabolism1.93140858
22MP0009785_altered_susceptibility_to1.82115784
23MP0002928_abnormal_bile_duct1.80289433
24MP0000716_abnormal_immune_system1.76447638
25MP0000689_abnormal_spleen_morphology1.76151292
26MP0002398_abnormal_bone_marrow1.71467811
27MP0003724_increased_susceptibility_to1.66756217
28MP0002653_abnormal_ependyma_morphology1.66512625
29MP0000372_irregular_coat_pigmentation1.64501272
30MP0005025_abnormal_response_to1.61820553
31MP0002148_abnormal_hypersensitivity_rea1.58678852
32MP0000015_abnormal_ear_pigmentation1.43184575
33MP0002405_respiratory_system_inflammati1.39489374
34MP0001968_abnormal_touch/_nociception1.38928633
35MP0003195_calcinosis1.37129063
36MP0005551_abnormal_eye_electrophysiolog1.33454745
37MP0003436_decreased_susceptibility_to1.31125117
38MP0002419_abnormal_innate_immunity1.30905137
39MP0008872_abnormal_physiological_respon1.30142154
40MP0002429_abnormal_blood_cell1.27800959
41MP0003303_peritoneal_inflammation1.26170835
42MP0004142_abnormal_muscle_tone1.25480107
43MP0002638_abnormal_pupillary_reflex1.23317311
44MP0002722_abnormal_immune_system1.22889545
45MP0004381_abnormal_hair_follicle1.21171931
46MP0005645_abnormal_hypothalamus_physiol1.20870171
47MP0001845_abnormal_inflammatory_respons1.20079620
48MP0005174_abnormal_tail_pigmentation1.19960721
49MP0004043_abnormal_pH_regulation1.13598399
50MP0003252_abnormal_bile_duct1.12011124
51MP0002277_abnormal_respiratory_mucosa1.10922326
52MP0001501_abnormal_sleep_pattern1.08193693
53MP0001663_abnormal_digestive_system1.07523965
54MP0010155_abnormal_intestine_physiology1.06699734
55MP0003646_muscle_fatigue1.06507431
56MP0003172_abnormal_lysosome_physiology1.05614048
57MP0006292_abnormal_olfactory_placode1.05578175
58MP0009745_abnormal_behavioral_response1.03671353
59MP0009764_decreased_sensitivity_to1.02591880
60MP0002009_preneoplasia0.99896319
61MP0002102_abnormal_ear_morphology0.99779764
62MP0002095_abnormal_skin_pigmentation0.97213827
63MP0002693_abnormal_pancreas_physiology0.95003363
64MP0008995_early_reproductive_senescence0.94943724
65MP0009333_abnormal_splenocyte_physiolog0.92797513
66MP0000427_abnormal_hair_cycle0.92405750
67MP0005084_abnormal_gallbladder_morpholo0.92154682
68MP0000703_abnormal_thymus_morphology0.91939341
69MP0000465_gastrointestinal_hemorrhage0.91463381
70MP0002876_abnormal_thyroid_physiology0.89818725
71MP0003866_abnormal_defecation0.86069980
72MP0002166_altered_tumor_susceptibility0.79691620
73MP0004742_abnormal_vestibular_system0.78780001
74MP0001764_abnormal_homeostasis0.78234029
75MP0003121_genomic_imprinting0.76498634
76MP0002136_abnormal_kidney_physiology0.76296425
77MP0005253_abnormal_eye_physiology0.75914792
78MP0008961_abnormal_basal_metabolism0.75611791
79MP0000371_diluted_coat_color0.74951236
80MP0008469_abnormal_protein_level0.73494969
81MP0005646_abnormal_pituitary_gland0.73294385
82MP0001919_abnormal_reproductive_system0.73012432
83MP0000631_abnormal_neuroendocrine_gland0.72673346
84MP0002933_joint_inflammation0.71318693
85MP0006072_abnormal_retinal_apoptosis0.71272952
86MP0005389_reproductive_system_phenotype0.69603875
87MP0005085_abnormal_gallbladder_physiolo0.69208000
88MP0008057_abnormal_DNA_replication0.68830355
89MP0002837_dystrophic_cardiac_calcinosis0.68648901
90MP0002736_abnormal_nociception_after0.68351101
91MP0002254_reproductive_system_inflammat0.65241304
92MP0002067_abnormal_sensory_capabilities0.65085241
93MP0008875_abnormal_xenobiotic_pharmacok0.64568539
94MP0004883_abnormal_blood_vessel0.63084546
95MP0002735_abnormal_chemical_nociception0.62005278
96MP0001905_abnormal_dopamine_level0.61227562
97MP0002733_abnormal_thermal_nociception0.60657654
98MP0002163_abnormal_gland_morphology0.60080262
99MP0001485_abnormal_pinna_reflex0.57979642
100MP0010386_abnormal_urinary_bladder0.57922592

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.12155930
2Panhypogammaglobulinemia (HP:0003139)4.17710272
3Gastrointestinal stroma tumor (HP:0100723)4.04032729
4Recurrent bronchitis (HP:0002837)3.91416082
5Recurrent sinusitis (HP:0011108)3.79384383
6Meningitis (HP:0001287)3.59228675
7Congenital stationary night blindness (HP:0007642)3.49465284
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.38133958
9Pancreatic cysts (HP:0001737)3.37164642
10Chronic sinusitis (HP:0011109)3.30408256
11Lymphopenia (HP:0001888)3.21970242
12Verrucae (HP:0200043)3.01651457
13Papilloma (HP:0012740)3.01651457
14IgG deficiency (HP:0004315)2.98970807
15Vasculitis (HP:0002633)2.96691892
16Chronic mucocutaneous candidiasis (HP:0002728)2.91684332
17Recurrent cutaneous fungal infections (HP:0011370)2.91684332
18Recurrent fungal infections (HP:0002841)2.91530238
19Mediastinal lymphadenopathy (HP:0100721)2.86753495
20Bile duct proliferation (HP:0001408)2.81722610
21Abnormal biliary tract physiology (HP:0012439)2.81722610
22Abnormality of B cell number (HP:0010975)2.81206246
23Abnormality of midbrain morphology (HP:0002418)2.80676709
24Molar tooth sign on MRI (HP:0002419)2.80676709
25Abnormality of cells of the lymphoid lineage (HP:0012140)2.77890787
26Hyperventilation (HP:0002883)2.75473935
27Stomatitis (HP:0010280)2.74509684
28Stomach cancer (HP:0012126)2.72053401
29Pancreatic fibrosis (HP:0100732)2.65892205
30Colitis (HP:0002583)2.63580368
31Recurrent pneumonia (HP:0006532)2.63064771
32Encephalitis (HP:0002383)2.62827137
33Abnormality of the prostate (HP:0008775)2.57857458
34Inflammation of the large intestine (HP:0002037)2.54240732
35Nephronophthisis (HP:0000090)2.52179967
36Chronic diarrhea (HP:0002028)2.50144388
37Recurrent bacterial skin infections (HP:0005406)2.48391466
38True hermaphroditism (HP:0010459)2.46105052
39Recurrent viral infections (HP:0004429)2.43265182
40Chronic otitis media (HP:0000389)2.42117010
41B lymphocytopenia (HP:0010976)2.41962208
42Bronchitis (HP:0012387)2.40763281
43Thyroiditis (HP:0100646)2.40314095
44Abnormality of the renal cortex (HP:0011035)2.39662753
45Hypoplasia of the thymus (HP:0000778)2.38126587
46Attenuation of retinal blood vessels (HP:0007843)2.37113581
47Abnormal rod and cone electroretinograms (HP:0008323)2.34146965
48Abnormality of the renal medulla (HP:0100957)2.31441280
49Severe combined immunodeficiency (HP:0004430)2.31427807
50Gastrointestinal inflammation (HP:0004386)2.27391276
51Cellulitis (HP:0100658)2.25520775
52Abnormality of T cells (HP:0002843)2.24060648
53Abnormal drinking behavior (HP:0030082)2.21647156
54Polydipsia (HP:0001959)2.21647156
55T lymphocytopenia (HP:0005403)2.20431970
56Abnormality of T cell number (HP:0011839)2.19266301
57Pulmonary infiltrates (HP:0002113)2.16260353
58Pustule (HP:0200039)2.14687799
59Chronic hepatic failure (HP:0100626)2.14532573
60Recurrent skin infections (HP:0001581)2.10693844
61Osteomyelitis (HP:0002754)2.10312585
62Retrobulbar optic neuritis (HP:0100654)2.09251847
63Optic neuritis (HP:0100653)2.09251847
64Restrictive lung disease (HP:0002091)2.05962274
65Emphysema (HP:0002097)2.05130283
66Recurrent lower respiratory tract infections (HP:0002783)2.04798137
67Tubular atrophy (HP:0000092)2.04590801
68Recurrent abscess formation (HP:0002722)2.03549459
69Abnormality of T cell physiology (HP:0011840)2.01994352
70Hematochezia (HP:0002573)2.01643914
71Sepsis (HP:0100806)2.00685596
72Elevated erythrocyte sedimentation rate (HP:0003565)1.99711486
73Neutropenia (HP:0001875)1.98325260
74Cystic liver disease (HP:0006706)1.97209021
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95956608
76Gastrointestinal infarctions (HP:0005244)1.94942920
77Obstructive lung disease (HP:0006536)1.94905179
78Chronic obstructive pulmonary disease (HP:0006510)1.94905179
79Abolished electroretinogram (ERG) (HP:0000550)1.92719643
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.92310620
81Medial flaring of the eyebrow (HP:0010747)1.91434931
82Asplenia (HP:0001746)1.90991976
83Hemoptysis (HP:0002105)1.88501318
84Type II lissencephaly (HP:0007260)1.88392093
85Myositis (HP:0100614)1.85255246
86Hypoproteinemia (HP:0003075)1.84812826
87Progressive inability to walk (HP:0002505)1.82245463
88Abnormality of eosinophils (HP:0001879)1.81878539
89Gaze-evoked nystagmus (HP:0000640)1.81201668
90Absent speech (HP:0001344)1.80729899
91Abnormality of the pleura (HP:0002103)1.78477336
92Inability to walk (HP:0002540)1.77635833
93Febrile seizures (HP:0002373)1.76991087
94Polyuria (HP:0000103)1.75581112
95Alveolar cell carcinoma (HP:0006519)1.75420058
96Skin rash (HP:0000988)1.72594499
97Eczematoid dermatitis (HP:0000976)1.72577825
98Lymphoma (HP:0002665)1.72539144
99Recurrent otitis media (HP:0000403)1.72496106
100Decreased circulating renin level (HP:0003351)1.72274882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.49252442
2BLK4.47457182
3FRK3.59713853
4TXK3.14062431
5RIPK42.91317452
6IRAK42.77799227
7SYK2.35371150
8GRK12.20191420
9MAP4K22.02685039
10ADRBK21.99062843
11BTK1.88919174
12IKBKE1.78608193
13BMPR21.71726496
14MST41.71487807
15TNK21.66106077
16TAOK31.60469137
17TEC1.49909362
18ITK1.49773462
19ACVR1B1.49627036
20GRK61.47250792
21WNK31.47210280
22LYN1.45785539
23SIK31.44711220
24CSF1R1.44004460
25MAPK131.38777054
26WNK41.38629859
27SIK21.38094001
28IKBKB1.37594833
29BMPR1B1.36360846
30ERN11.35586703
31NUAK11.35425493
32TYK21.33107058
33TLK11.31092853
34JAK31.27580381
35IRAK11.26717438
36MARK31.22888555
37INSRR1.19280391
38PRKCQ1.15024447
39ZAK1.12332462
40PINK11.09069490
41OXSR11.07636245
42CAMKK21.03140255
43TRIM281.02387894
44HCK1.02243381
45LCK1.01558306
46FES0.90921215
47STK390.87034198
48NLK0.86758793
49ADRBK10.85108510
50PIK3CG0.84202918
51KIT0.82052042
52MAP3K100.77696656
53PAK30.74317416
54MAPK150.73650684
55CHUK0.71285508
56MAP3K130.66016896
57CSK0.64784354
58CASK0.64253608
59NTRK30.62556562
60PKN10.61716724
61MAP3K140.60949156
62STK110.59661460
63MAP3K40.58249995
64ABL10.55326448
65PIM10.52503940
66MAPK120.52007369
67JAK10.51190984
68IRAK20.50791553
69SGK20.50733212
70TBK10.50697436
71DYRK1A0.49310741
72ZAP700.49146290
73CAMK10.48324778
74PDK10.44679507
75MAP2K20.43348308
76PTK2B0.42968319
77PASK0.42426552
78JAK20.42150702
79MAP3K70.39400673
80MAP2K60.39104621
81FYN0.39028125
82MAP2K10.38637860
83HIPK20.37749203
84PRKCZ0.37512757
85STK100.36344440
86BRSK20.36192255
87DAPK20.34643297
88FGFR20.34131791
89DYRK20.33542451
90CSNK1A10.32723199
91MAPK70.32146070
92MAPK110.31777781
93PRKCE0.31115228
94PDK20.30971404
95CAMKK10.30220133
96MARK20.28794123
97DYRK1B0.28670678
98CDC42BPA0.27316592
99MAPKAPK30.27245393
100PRKACA0.27070981

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.14160315
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.05797483
3Asthma_Homo sapiens_hsa053104.01176200
4Allograft rejection_Homo sapiens_hsa053303.85063797
5Autoimmune thyroid disease_Homo sapiens_hsa053203.72004396
6Graft-versus-host disease_Homo sapiens_hsa053323.65552200
7Type I diabetes mellitus_Homo sapiens_hsa049403.24197415
8B cell receptor signaling pathway_Homo sapiens_hsa046622.80025006
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73425867
10Staphylococcus aureus infection_Homo sapiens_hsa051502.25960331
11Antigen processing and presentation_Homo sapiens_hsa046122.25390192
12Leishmaniasis_Homo sapiens_hsa051402.09229933
13Hematopoietic cell lineage_Homo sapiens_hsa046401.80427367
14Phototransduction_Homo sapiens_hsa047441.73859247
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69031740
16Linoleic acid metabolism_Homo sapiens_hsa005911.61748215
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.58715932
18Viral myocarditis_Homo sapiens_hsa054161.56330523
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48978468
20Rheumatoid arthritis_Homo sapiens_hsa053231.33964101
21Tuberculosis_Homo sapiens_hsa051521.26195039
22T cell receptor signaling pathway_Homo sapiens_hsa046601.20774029
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15693285
24Ether lipid metabolism_Homo sapiens_hsa005651.13137848
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12691547
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11416739
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09653400
28Toxoplasmosis_Homo sapiens_hsa051451.06843977
29Herpes simplex infection_Homo sapiens_hsa051681.06703024
30Nitrogen metabolism_Homo sapiens_hsa009101.06047214
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05642654
32Osteoclast differentiation_Homo sapiens_hsa043801.05121134
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01910176
34Butanoate metabolism_Homo sapiens_hsa006500.94097702
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90489950
36Jak-STAT signaling pathway_Homo sapiens_hsa046300.90422514
37ABC transporters_Homo sapiens_hsa020100.89551979
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87176523
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86837061
40Regulation of autophagy_Homo sapiens_hsa041400.85475755
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85291702
42Influenza A_Homo sapiens_hsa051640.82574134
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81065498
44Homologous recombination_Homo sapiens_hsa034400.80708537
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.78459788
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76792406
47Caffeine metabolism_Homo sapiens_hsa002320.76416435
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74808406
49Arachidonic acid metabolism_Homo sapiens_hsa005900.70865498
50Measles_Homo sapiens_hsa051620.68463759
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67638479
52Olfactory transduction_Homo sapiens_hsa047400.67435019
53Taste transduction_Homo sapiens_hsa047420.66784372
54Chemokine signaling pathway_Homo sapiens_hsa040620.65445434
55Nicotine addiction_Homo sapiens_hsa050330.64272246
56Morphine addiction_Homo sapiens_hsa050320.63836558
57Dorso-ventral axis formation_Homo sapiens_hsa043200.61986910
58Fanconi anemia pathway_Homo sapiens_hsa034600.61658079
59Tryptophan metabolism_Homo sapiens_hsa003800.60400597
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60298118
61Selenocompound metabolism_Homo sapiens_hsa004500.57993656
62Phagosome_Homo sapiens_hsa041450.56830582
63Serotonergic synapse_Homo sapiens_hsa047260.56507790
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56311587
65Epstein-Barr virus infection_Homo sapiens_hsa051690.55638257
66Basal transcription factors_Homo sapiens_hsa030220.54828342
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52523254
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51971611
69RNA degradation_Homo sapiens_hsa030180.51443547
70Glycerolipid metabolism_Homo sapiens_hsa005610.51388530
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51088510
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50720755
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.46588596
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44693032
75African trypanosomiasis_Homo sapiens_hsa051430.43748526
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.42546846
77Non-homologous end-joining_Homo sapiens_hsa034500.38889881
78TNF signaling pathway_Homo sapiens_hsa046680.35282984
79Insulin secretion_Homo sapiens_hsa049110.33802780
80Ovarian steroidogenesis_Homo sapiens_hsa049130.32934488
81HTLV-I infection_Homo sapiens_hsa051660.31120288
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29611418
83Calcium signaling pathway_Homo sapiens_hsa040200.29064526
84Systemic lupus erythematosus_Homo sapiens_hsa053220.27846296
85Peroxisome_Homo sapiens_hsa041460.27593865
86Glutamatergic synapse_Homo sapiens_hsa047240.27491999
87Fat digestion and absorption_Homo sapiens_hsa049750.25798358
88Circadian entrainment_Homo sapiens_hsa047130.25562787
89Long-term depression_Homo sapiens_hsa047300.24595403
90Protein export_Homo sapiens_hsa030600.23737919
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23203169
92Salivary secretion_Homo sapiens_hsa049700.22517698
93MAPK signaling pathway_Homo sapiens_hsa040100.22321527
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21819527
95Cholinergic synapse_Homo sapiens_hsa047250.21609747
96GABAergic synapse_Homo sapiens_hsa047270.21438463
97Platelet activation_Homo sapiens_hsa046110.21367129
98FoxO signaling pathway_Homo sapiens_hsa040680.20670577
99Oxidative phosphorylation_Homo sapiens_hsa001900.19242584
100Retinol metabolism_Homo sapiens_hsa008300.17416003

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