FCRL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.66094030
2negative regulation of cell killing (GO:0031342)6.65480312
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.65480312
4regulation of B cell receptor signaling pathway (GO:0050855)6.63672813
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88756388
6cellular response to interleukin-15 (GO:0071350)5.85410653
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.78345782
8B cell receptor signaling pathway (GO:0050853)5.67632437
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.64065298
10response to interleukin-15 (GO:0070672)5.57023966
11antigen processing and presentation of endogenous antigen (GO:0019883)5.56061728
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.17236851
13regulation of B cell differentiation (GO:0045577)4.97305078
14positive regulation of B cell differentiation (GO:0045579)4.91731808
15negative thymic T cell selection (GO:0045060)4.88316815
16regulation of gamma-delta T cell activation (GO:0046643)4.86417123
17negative T cell selection (GO:0043383)4.79526260
18positive thymic T cell selection (GO:0045059)4.75373975
19regulation of gamma-delta T cell differentiation (GO:0045586)4.74927323
20leukocyte aggregation (GO:0070486)4.45993421
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.45440701
22positive T cell selection (GO:0043368)4.27746413
23thymic T cell selection (GO:0045061)4.17524814
24activated T cell proliferation (GO:0050798)4.11951875
25T cell selection (GO:0045058)4.08397792
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00750691
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00169268
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.97911909
29antigen receptor-mediated signaling pathway (GO:0050851)3.87524687
30negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.82244674
31negative regulation of T-helper cell differentiation (GO:0045623)3.82244674
32defense response to protozoan (GO:0042832)3.78649802
33negative regulation of T cell mediated immunity (GO:0002710)3.78265016
34positive regulation of granulocyte differentiation (GO:0030854)3.76272965
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.75955727
36macrophage activation involved in immune response (GO:0002281)3.64952831
37immunoglobulin mediated immune response (GO:0016064)3.63164791
38regulation of antigen processing and presentation (GO:0002577)3.60871855
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51760600
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.51760600
41modulation by symbiont of host immune response (GO:0052553)3.51760600
42positive regulation by symbiont of host defense response (GO:0052509)3.51760600
43modulation by symbiont of host defense response (GO:0052031)3.51760600
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51760600
45T cell migration (GO:0072678)3.51519036
46regulation of alpha-beta T cell proliferation (GO:0046640)3.50749868
47interferon-gamma production (GO:0032609)3.50126603
48negative regulation of leukocyte mediated immunity (GO:0002704)3.49355729
49detection of bacterium (GO:0016045)3.49050182
50B cell homeostasis (GO:0001782)3.42785187
51detection of other organism (GO:0098543)3.42602474
52neutrophil activation involved in immune response (GO:0002283)3.38934028
53regulation of interferon-beta biosynthetic process (GO:0045357)3.33540051
54cellular response to type I interferon (GO:0071357)3.33346463
55type I interferon signaling pathway (GO:0060337)3.33346463
56response to type I interferon (GO:0034340)3.32002614
57production of molecular mediator involved in inflammatory response (GO:0002532)3.31210032
58negative regulation of B cell proliferation (GO:0030889)3.30792003
59antigen processing and presentation via MHC class Ib (GO:0002475)3.30201391
60negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26744345
61T cell receptor signaling pathway (GO:0050852)3.26491524
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26361475
63regulation of isotype switching to IgG isotypes (GO:0048302)3.25246310
64regulation of T cell mediated cytotoxicity (GO:0001914)3.25159606
65response to protozoan (GO:0001562)3.23961962
66regulation of natural killer cell mediated immunity (GO:0002715)3.22363274
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22363274
68negative regulation of interleukin-12 production (GO:0032695)3.21702281
69regulation of regulatory T cell differentiation (GO:0045589)3.19050441
70negative regulation of alpha-beta T cell activation (GO:0046636)3.17464852
71tolerance induction (GO:0002507)3.17442324
72positive regulation of humoral immune response (GO:0002922)3.17238124
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.16980720
74interferon-gamma-mediated signaling pathway (GO:0060333)3.14627654
75germinal center formation (GO:0002467)3.13813794
76B cell proliferation (GO:0042100)3.12413741
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11448927
78mast cell activation (GO:0045576)3.10037830
79regulation of T cell tolerance induction (GO:0002664)3.09952509
80positive regulation of B cell activation (GO:0050871)3.08875176
81positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08230600
82regulation of B cell proliferation (GO:0030888)3.06320454
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04533786
84dendritic cell chemotaxis (GO:0002407)3.02899239
85NIK/NF-kappaB signaling (GO:0038061)3.01172690
86B cell mediated immunity (GO:0019724)3.00535729
87immune response-activating cell surface receptor signaling pathway (GO:0002429)3.00118664
88positive regulation of isotype switching (GO:0045830)2.99241776
89negative regulation of adaptive immune response (GO:0002820)2.98235548
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97826002
91neutrophil activation (GO:0042119)2.96034077
92regulation of T cell receptor signaling pathway (GO:0050856)2.94270733
93lymphocyte homeostasis (GO:0002260)2.93751295
94regulation of granulocyte differentiation (GO:0030852)2.90810320
95cellular extravasation (GO:0045123)2.89750093
96myeloid cell activation involved in immune response (GO:0002275)2.87514673
97positive regulation of defense response to virus by host (GO:0002230)2.86629563
98regulation of alpha-beta T cell activation (GO:0046634)2.85836844
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84450030
100positive regulation of antigen processing and presentation (GO:0002579)2.82958959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.08409360
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.64103071
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.20744901
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.90425044
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80586673
6RUNX_20019798_ChIP-Seq_JUKART_Human3.73901799
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.61060727
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46009374
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30335221
10MYB_26560356_Chip-Seq_TH2_Human3.14301361
11MYC_22102868_ChIP-Seq_BL_Human3.01631035
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93432020
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.92865260
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92300263
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88760148
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.67972933
17MYB_26560356_Chip-Seq_TH1_Human2.62717975
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61351131
19MAF_26560356_Chip-Seq_TH1_Human2.40371135
20SPI1_23547873_ChIP-Seq_NB4_Human2.24863875
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20963691
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20913498
23GATA3_27048872_Chip-Seq_THYMUS_Human2.17296055
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15850382
25SCL_19346495_ChIP-Seq_HPC-7_Human2.14803804
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14194293
27UTX_26944678_Chip-Seq_JUKART_Human2.09262054
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93360408
29SPI1_23127762_ChIP-Seq_K562_Human1.92609643
30GATA3_26560356_Chip-Seq_TH2_Human1.90851925
31CIITA_25753668_ChIP-Seq_RAJI_Human1.90376052
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82864230
33VDR_24763502_ChIP-Seq_THP-1_Human1.77707015
34MAF_26560356_Chip-Seq_TH2_Human1.74553169
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.73571970
36VDR_21846776_ChIP-Seq_THP-1_Human1.68598957
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.64683380
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59854640
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.58655362
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55122194
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54854415
42VDR_24787735_ChIP-Seq_THP-1_Human1.54543545
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49862058
44TCF7_22412390_ChIP-Seq_EML_Mouse1.48013922
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45930354
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42261663
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40051237
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39607790
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35109920
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32842196
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29451143
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.28237645
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27254072
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26507647
55KDM2B_26808549_Chip-Seq_DND41_Human1.25659531
56SMRT_27268052_Chip-Seq_Bcells_Human1.22293022
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17503262
58PU_27001747_Chip-Seq_BMDM_Mouse1.17441157
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.17269105
60GATA1_22025678_ChIP-Seq_K562_Human1.17049013
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16416962
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15770101
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15131732
64EZH2_22144423_ChIP-Seq_EOC_Human1.13304497
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11390520
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07423526
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06090057
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03967916
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02681162
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01857271
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01314924
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01237924
73GATA3_26560356_Chip-Seq_TH1_Human0.98115140
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96535655
75PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96413515
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96231890
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95084759
78GATA1_19941826_ChIP-Seq_K562_Human0.89366628
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89295141
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88480386
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88442055
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87309478
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86219819
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85360097
85BCL6_27268052_Chip-Seq_Bcells_Human0.84992466
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84452886
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83624486
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81838167
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.81435307
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80267890
91BCOR_27268052_Chip-Seq_Bcells_Human0.79741368
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79718444
93GATA2_19941826_ChIP-Seq_K562_Human0.77725549
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77702801
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75004296
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.74128606
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73007882
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72279031
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69349029
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67993275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.47283695
2MP0005671_abnormal_response_to4.14717143
3MP0001800_abnormal_humoral_immune4.06503361
4MP0003763_abnormal_thymus_physiology4.03030077
5MP0000685_abnormal_immune_system3.67683672
6MP0001790_abnormal_immune_system3.55808383
7MP0005387_immune_system_phenotype3.55808383
8MP0005000_abnormal_immune_tolerance3.29548953
9MP0003436_decreased_susceptibility_to3.21868226
10MP0002723_abnormal_immune_serum3.05231527
11MP0003724_increased_susceptibility_to3.03337756
12MP0002452_abnormal_antigen_presenting3.02554101
13MP0002420_abnormal_adaptive_immunity2.94058939
14MP0001819_abnormal_immune_cell2.89014341
15MP0003303_peritoneal_inflammation2.67299594
16MP0005025_abnormal_response_to2.64800122
17MP0009785_altered_susceptibility_to2.56820182
18MP0002398_abnormal_bone_marrow2.47939027
19MP0002419_abnormal_innate_immunity2.39586465
20MP0000716_abnormal_immune_system2.36209415
21MP0002405_respiratory_system_inflammati2.22070352
22MP0000689_abnormal_spleen_morphology2.16248513
23MP0002148_abnormal_hypersensitivity_rea2.13476382
24MP0010155_abnormal_intestine_physiology2.10670538
25MP0006082_CNS_inflammation2.09145344
26MP0009333_abnormal_splenocyte_physiolog2.07471912
27MP0003183_abnormal_peptide_metabolism2.00978529
28MP0003300_gastrointestinal_ulcer1.97394167
29MP0002722_abnormal_immune_system1.96265450
30MP0003866_abnormal_defecation1.91654840
31MP0000703_abnormal_thymus_morphology1.88427890
32MP0005310_abnormal_salivary_gland1.86410058
33MP0002429_abnormal_blood_cell1.83412079
34MP0001873_stomach_inflammation1.82201018
35MP0004947_skin_inflammation1.80260292
36MP0005075_abnormal_melanosome_morpholog1.77901929
37MP0001845_abnormal_inflammatory_respons1.75127328
38MP0008260_abnormal_autophagy1.70004490
39MP0004381_abnormal_hair_follicle1.66876401
40MP0003172_abnormal_lysosome_physiology1.66862773
41MP0005464_abnormal_platelet_physiology1.63635156
42MP0002166_altered_tumor_susceptibility1.61509508
43MP0002132_abnormal_respiratory_system1.59686107
44MP0002138_abnormal_hepatobiliary_system1.57248875
45MP0003787_abnormal_imprinting1.39499291
46MP0000569_abnormal_digit_pigmentation1.35269562
47MP0001853_heart_inflammation1.33333604
48MP0000465_gastrointestinal_hemorrhage1.29855571
49MP0001533_abnormal_skeleton_physiology1.26742270
50MP0002396_abnormal_hematopoietic_system1.23831279
51MP0008469_abnormal_protein_level1.23056554
52MP0008057_abnormal_DNA_replication1.22939118
53MP0009764_decreased_sensitivity_to1.11755991
54MP0000015_abnormal_ear_pigmentation1.09475714
55MP0002009_preneoplasia1.07788183
56MP0000858_altered_metastatic_potential1.05594575
57MP0001986_abnormal_taste_sensitivity1.03564131
58MP0004883_abnormal_blood_vessel1.03176642
59MP0003045_fibrosis1.00940434
60MP0002933_joint_inflammation0.99126206
61MP0001851_eye_inflammation0.96643170
62MP0005451_abnormal_body_composition0.95689131
63MP0002006_tumorigenesis0.95253076
64MP0001663_abnormal_digestive_system0.90216182
65MP0008877_abnormal_DNA_methylation0.87155997
66MP0009278_abnormal_bone_marrow0.86532458
67MP0002163_abnormal_gland_morphology0.86396369
68MP0003828_pulmonary_edema0.83203287
69MP0002019_abnormal_tumor_incidence0.82545337
70MP0002277_abnormal_respiratory_mucosa0.80642742
71MP0003191_abnormal_cellular_cholesterol0.75137756
72MP0002998_abnormal_bone_remodeling0.72438075
73MP0000249_abnormal_blood_vessel0.72281826
74MP0004808_abnormal_hematopoietic_stem0.70722263
75MP0003690_abnormal_glial_cell0.70253790
76MP0002136_abnormal_kidney_physiology0.65224602
77MP0002928_abnormal_bile_duct0.63625724
78MP0009763_increased_sensitivity_to0.61909257
79MP0003448_altered_tumor_morphology0.61749577
80MP0001348_abnormal_lacrimal_gland0.61367618
81MP0002653_abnormal_ependyma_morphology0.57444149
82MP0000490_abnormal_crypts_of0.57215119
83MP0005174_abnormal_tail_pigmentation0.56785134
84MP0003091_abnormal_cell_migration0.56162410
85MP0004510_myositis0.55463813
86MP0004264_abnormal_extraembryonic_tissu0.55363630
87MP0000371_diluted_coat_color0.54650695
88MP0005166_decreased_susceptibility_to0.54584308
89MP0008874_decreased_physiological_sensi0.53777743
90MP0005164_abnormal_response_to0.53500512
91MP0005397_hematopoietic_system_phenotyp0.52313008
92MP0001545_abnormal_hematopoietic_system0.52313008
93MP0003252_abnormal_bile_duct0.49780772
94MP0009765_abnormal_xenobiotic_induced0.48256853
95MP0005381_digestive/alimentary_phenotyp0.46165135
96MP0002693_abnormal_pancreas_physiology0.45314717
97MP0005379_endocrine/exocrine_gland_phen0.44255106
98MP0000604_amyloidosis0.40049569
99MP0004130_abnormal_muscle_cell0.39244226
100MP0009642_abnormal_blood_homeostasis0.36737736

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.46902212
2Eczematoid dermatitis (HP:0000976)5.17218788
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.99092969
4T lymphocytopenia (HP:0005403)4.83040307
5Meningitis (HP:0001287)4.72240349
6Panhypogammaglobulinemia (HP:0003139)4.60636665
7Abnormality of T cell number (HP:0011839)4.59532036
8Recurrent bacterial skin infections (HP:0005406)4.55387282
9Colitis (HP:0002583)4.40252010
10Recurrent bronchitis (HP:0002837)4.40052923
11Gastrointestinal stroma tumor (HP:0100723)4.38981965
12Recurrent abscess formation (HP:0002722)4.35835469
13Recurrent fungal infections (HP:0002841)4.26620424
14Elevated erythrocyte sedimentation rate (HP:0003565)4.11583684
15Vasculitis (HP:0002633)4.10220249
16Recurrent cutaneous fungal infections (HP:0011370)4.06377906
17Chronic mucocutaneous candidiasis (HP:0002728)4.06377906
18Lymphopenia (HP:0001888)4.01695449
19Abnormality of T cells (HP:0002843)3.95839574
20Recurrent sinusitis (HP:0011108)3.95829260
21Encephalitis (HP:0002383)3.94841223
22Myositis (HP:0100614)3.93551692
23Inflammation of the large intestine (HP:0002037)3.89481336
24Chronic diarrhea (HP:0002028)3.87569136
25Recurrent viral infections (HP:0004429)3.83164418
26Mediastinal lymphadenopathy (HP:0100721)3.82517675
27Verrucae (HP:0200043)3.80199172
28Papilloma (HP:0012740)3.80199172
29Gastrointestinal inflammation (HP:0004386)3.73910354
30Cellulitis (HP:0100658)3.71786644
31Pustule (HP:0200039)3.69676032
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.68800535
33IgG deficiency (HP:0004315)3.62303000
34Retrobulbar optic neuritis (HP:0100654)3.60681707
35Optic neuritis (HP:0100653)3.60681707
36Severe combined immunodeficiency (HP:0004430)3.55767641
37Recurrent skin infections (HP:0001581)3.48407561
38Abnormality of macrophages (HP:0004311)3.47850713
39Stomatitis (HP:0010280)3.45404589
40Orchitis (HP:0100796)3.43378357
41Gastrointestinal infarctions (HP:0005244)3.39988579
42Pulmonary infiltrates (HP:0002113)3.35544021
43Chronic obstructive pulmonary disease (HP:0006510)3.26995148
44Obstructive lung disease (HP:0006536)3.26995148
45Abnormality of eosinophils (HP:0001879)3.19692672
46Leukocytosis (HP:0001974)3.13279561
47Abnormality of T cell physiology (HP:0011840)3.12065592
48Increased IgM level (HP:0003496)2.99520239
49Viral hepatitis (HP:0006562)2.94905588
50IgM deficiency (HP:0002850)2.94853966
51Osteomyelitis (HP:0002754)2.94777859
52Spontaneous hematomas (HP:0007420)2.93889511
53Granulocytopenia (HP:0001913)2.92611457
54Eosinophilia (HP:0001880)2.86610057
55Sepsis (HP:0100806)2.86447050
56Recurrent pneumonia (HP:0006532)2.82354899
57Emphysema (HP:0002097)2.80382296
58Chronic sinusitis (HP:0011109)2.78958917
59Increased IgE level (HP:0003212)2.75849605
60Combined immunodeficiency (HP:0005387)2.75306451
61Hypoplasia of the thymus (HP:0000778)2.74332721
62Chronic otitis media (HP:0000389)2.73505726
63Chest pain (HP:0100749)2.72748750
64Recurrent gram-negative bacterial infections (HP:0005420)2.68477834
65Keratoconjunctivitis sicca (HP:0001097)2.62894460
66Prolonged bleeding time (HP:0003010)2.61251750
67Hemoptysis (HP:0002105)2.60068257
68Restrictive lung disease (HP:0002091)2.55604532
69Stomach cancer (HP:0012126)2.51277964
70Recurrent lower respiratory tract infections (HP:0002783)2.50786260
71Lymphoma (HP:0002665)2.49028259
72Bronchitis (HP:0012387)2.48606069
73Keratoconjunctivitis (HP:0001096)2.47324905
74Thyroiditis (HP:0100646)2.46853580
75Skin rash (HP:0000988)2.45957768
76Gingivitis (HP:0000230)2.39694879
77Papilledema (HP:0001085)2.33766580
78Abnormality of B cell number (HP:0010975)2.31744398
79Autoimmune hemolytic anemia (HP:0001890)2.30992076
80Abnormality of the prostate (HP:0008775)2.26072317
81Recurrent otitis media (HP:0000403)2.25684183
82Epistaxis (HP:0000421)2.24380437
83Abnormality of the fingertips (HP:0001211)2.23353462
84Urticaria (HP:0001025)2.23346784
85Pulmonary embolism (HP:0002204)2.21811302
86Abnormality of the pleura (HP:0002103)2.20192697
87Hematochezia (HP:0002573)2.19688905
88Fatigue (HP:0012378)2.18412710
89IgA deficiency (HP:0002720)2.13079906
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12499246
91Nasal polyposis (HP:0100582)2.10817699
92Hypochromic anemia (HP:0001931)2.10518766
93Anorexia (HP:0002039)2.07120015
94Gingival bleeding (HP:0000225)2.04420486
95Skin ulcer (HP:0200042)2.03890025
96Arterial thrombosis (HP:0004420)2.00989850
97Joint swelling (HP:0001386)1.99168697
98Hypergammaglobulinemia (HP:0010702)1.97288286
99B lymphocytopenia (HP:0010976)1.96163626
100Arthralgia (HP:0002829)1.92594559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.32198763
2TXK4.03195002
3RIPK43.52972306
4BLK3.09148763
5IRAK42.77859757
6ERN12.51311284
7TYK22.42664474
8BTK2.22620705
9SYK2.21089969
10MAP3K142.15219620
11TAOK32.12918864
12GRK62.12606760
13JAK31.97848232
14FES1.92833661
15MARK31.89497860
16MAP3K101.87145461
17CSK1.85825309
18MAP3K131.85807596
19JAK11.84016860
20ITK1.82848151
21IKBKE1.82509386
22SIK31.78547739
23HCK1.74584317
24ZAP701.71580045
25PDK21.64037746
26STK101.62037820
27TNK21.60381582
28CSF1R1.57006594
29SIK21.54693428
30BMPR21.51779016
31PRPF4B1.42633334
32LYN1.39784957
33IKBKB1.36916585
34EPHA31.35773211
35NLK1.33675454
36EPHB11.32150818
37TBK11.32090728
38LCK1.30546209
39IRAK11.27134244
40TEC1.26786841
41MAP2K31.23165846
42FGFR41.13053361
43MAPK71.06736743
44MAPK121.05676259
45MAP2K21.05455439
46FGFR30.96847729
47PRKCQ0.94502800
48MST40.87592358
49PDK10.87279311
50NEK60.86090360
51HIPK20.85618311
52PIM10.85236787
53JAK20.84064094
54FGR0.82705506
55CDK40.79720017
56KIT0.79164522
57MAP3K70.76133444
58PASK0.75541358
59PTK2B0.74606978
60MAP3K30.71078751
61MAP3K10.67895914
62IRAK20.67489226
63MARK20.65205154
64BRD40.62873763
65CHUK0.62505185
66CDC42BPA0.62222414
67TGFBR20.60004153
68FYN0.58285677
69TRIM280.56900038
70GRK50.55630939
71PIK3CG0.55334669
72TAOK10.55142681
73SGK30.54395652
74FRK0.53834238
75STK110.52808159
76MAPK110.51959443
77LRRK20.51745859
78PDPK10.50044721
79CAMKK10.46969682
80MAP3K110.43709316
81MAPKAPK30.43291722
82PRKD20.42570073
83SGK20.40688708
84CAMKK20.40286827
85YES10.37274681
86MATK0.36723345
87ABL10.34785666
88MAPKAPK20.31516944
89TRIB30.30177350
90ACVR1B0.29804581
91CLK10.29221108
92PRKCH0.29007021
93MELK0.25215132
94DYRK1B0.25179425
95KSR20.23133949
96CDK60.22986679
97DYRK1A0.22593854
98EGFR0.21842709
99NTRK30.20539199
100PRKD10.20344194

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.16890912
2Graft-versus-host disease_Homo sapiens_hsa053323.83689467
3Allograft rejection_Homo sapiens_hsa053303.47355928
4Autoimmune thyroid disease_Homo sapiens_hsa053203.29307747
5B cell receptor signaling pathway_Homo sapiens_hsa046623.25078497
6Antigen processing and presentation_Homo sapiens_hsa046122.79134714
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77811215
8Type I diabetes mellitus_Homo sapiens_hsa049402.68655399
9Leishmaniasis_Homo sapiens_hsa051402.66793149
10Asthma_Homo sapiens_hsa053102.58123186
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.55463274
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53738020
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.31288678
14Staphylococcus aureus infection_Homo sapiens_hsa051502.20404636
15Osteoclast differentiation_Homo sapiens_hsa043802.16855726
16T cell receptor signaling pathway_Homo sapiens_hsa046602.15652441
17Viral myocarditis_Homo sapiens_hsa054162.03528989
18Hematopoietic cell lineage_Homo sapiens_hsa046401.89696791
19Toxoplasmosis_Homo sapiens_hsa051451.70375348
20Tuberculosis_Homo sapiens_hsa051521.62298453
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61052381
22Measles_Homo sapiens_hsa051621.58874818
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51327322
24Herpes simplex infection_Homo sapiens_hsa051681.51288835
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46101134
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43273370
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43009143
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.36625246
29Chemokine signaling pathway_Homo sapiens_hsa040621.36391443
30Influenza A_Homo sapiens_hsa051641.32201703
31Acute myeloid leukemia_Homo sapiens_hsa052211.31550867
32TNF signaling pathway_Homo sapiens_hsa046681.17066562
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14225991
34Hepatitis B_Homo sapiens_hsa051611.02820513
35Non-small cell lung cancer_Homo sapiens_hsa052230.95682257
36Epstein-Barr virus infection_Homo sapiens_hsa051690.95203972
37Rheumatoid arthritis_Homo sapiens_hsa053230.94896751
38Malaria_Homo sapiens_hsa051440.92835192
39Platelet activation_Homo sapiens_hsa046110.89810462
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88345782
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84202332
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81707205
43Apoptosis_Homo sapiens_hsa042100.80681029
44Hepatitis C_Homo sapiens_hsa051600.78154426
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.76981682
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76205609
47HTLV-I infection_Homo sapiens_hsa051660.75662844
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74385701
49Phagosome_Homo sapiens_hsa041450.71486185
50Legionellosis_Homo sapiens_hsa051340.70986094
51Pancreatic cancer_Homo sapiens_hsa052120.69560275
52African trypanosomiasis_Homo sapiens_hsa051430.68330356
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64882814
54VEGF signaling pathway_Homo sapiens_hsa043700.62269342
55FoxO signaling pathway_Homo sapiens_hsa040680.61796045
56Regulation of autophagy_Homo sapiens_hsa041400.60879292
57Viral carcinogenesis_Homo sapiens_hsa052030.59474737
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57058900
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.56588918
60Inositol phosphate metabolism_Homo sapiens_hsa005620.55834211
61Choline metabolism in cancer_Homo sapiens_hsa052310.55675405
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55256777
63Shigellosis_Homo sapiens_hsa051310.52577621
64Chronic myeloid leukemia_Homo sapiens_hsa052200.52010276
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.51032755
66Dorso-ventral axis formation_Homo sapiens_hsa043200.50706010
67Prolactin signaling pathway_Homo sapiens_hsa049170.48786845
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.47024370
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.46753669
70Pertussis_Homo sapiens_hsa051330.46618003
71Insulin resistance_Homo sapiens_hsa049310.45298209
72MAPK signaling pathway_Homo sapiens_hsa040100.44439801
73mTOR signaling pathway_Homo sapiens_hsa041500.44093665
74Colorectal cancer_Homo sapiens_hsa052100.43779002
75Other glycan degradation_Homo sapiens_hsa005110.40632438
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40502884
77Renal cell carcinoma_Homo sapiens_hsa052110.39979203
78Prostate cancer_Homo sapiens_hsa052150.39205075
79ABC transporters_Homo sapiens_hsa020100.37166603
80Endometrial cancer_Homo sapiens_hsa052130.35773350
81Endocytosis_Homo sapiens_hsa041440.34172517
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34010832
83Glycerolipid metabolism_Homo sapiens_hsa005610.34001376
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.31404560
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26428381
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25896895
87Notch signaling pathway_Homo sapiens_hsa043300.24977595
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24919932
89GnRH signaling pathway_Homo sapiens_hsa049120.24401569
90Ras signaling pathway_Homo sapiens_hsa040140.22994690
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20310280
92Type II diabetes mellitus_Homo sapiens_hsa049300.20218347
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18304269
94Rap1 signaling pathway_Homo sapiens_hsa040150.17400195
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15733447
96Long-term potentiation_Homo sapiens_hsa047200.15400512
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15266748
98Cholinergic synapse_Homo sapiens_hsa047250.14892888
99HIF-1 signaling pathway_Homo sapiens_hsa040660.14450407
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14214606

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