FCRL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)8.02553982
2regulation of interferon-beta biosynthetic process (GO:0045357)7.24614116
3antigen processing and presentation of endogenous antigen (GO:0019883)6.47101771
4B cell proliferation (GO:0042100)6.03367226
5positive regulation of gamma-delta T cell activation (GO:0046645)5.92034325
6regulation of B cell differentiation (GO:0045577)5.48518113
7mature B cell differentiation (GO:0002335)5.27049515
8protein K11-linked deubiquitination (GO:0035871)5.21943516
9positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.01804025
10cellular response to interleukin-15 (GO:0071350)4.96811538
11* regulation of B cell receptor signaling pathway (GO:0050855)4.84444877
12positive regulation of interferon-alpha production (GO:0032727)4.83830818
13positive regulation of B cell differentiation (GO:0045579)4.78203229
14response to interleukin-15 (GO:0070672)4.76377944
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69153600
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69153600
17positive regulation by symbiont of host defense response (GO:0052509)4.68835273
18modulation by symbiont of host defense response (GO:0052031)4.68835273
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68835273
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68835273
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.68835273
22modulation by symbiont of host immune response (GO:0052553)4.68835273
23regulation of interferon-alpha production (GO:0032647)4.65317837
24regulation of B cell proliferation (GO:0030888)4.51370897
25negative regulation of B cell proliferation (GO:0030889)4.50354173
26indole-containing compound catabolic process (GO:0042436)4.49945876
27indolalkylamine catabolic process (GO:0046218)4.49945876
28tryptophan catabolic process (GO:0006569)4.49945876
29I-kappaB phosphorylation (GO:0007252)4.43717090
30regulation of interleukin-12 biosynthetic process (GO:0045075)4.40979446
31monoubiquitinated protein deubiquitination (GO:0035520)4.36958039
32positive thymic T cell selection (GO:0045059)4.32410356
33cellular response to zinc ion (GO:0071294)4.20555284
34macrophage activation involved in immune response (GO:0002281)4.19702280
35positive regulation of developmental pigmentation (GO:0048087)4.12845154
36defense response to protozoan (GO:0042832)4.07184213
37protein K48-linked deubiquitination (GO:0071108)4.02968339
38B cell homeostasis (GO:0001782)4.02955756
39indolalkylamine metabolic process (GO:0006586)4.01960831
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.97164946
41regulation of gamma-delta T cell activation (GO:0046643)3.93671100
42regulation of gamma-delta T cell differentiation (GO:0045586)3.88176586
43regulation of interferon-gamma biosynthetic process (GO:0045072)3.86797371
44phospholipid translocation (GO:0045332)3.85606614
45lipid translocation (GO:0034204)3.85606614
46signal peptide processing (GO:0006465)3.84401375
47B cell activation (GO:0042113)3.84260778
48cilium or flagellum-dependent cell motility (GO:0001539)3.82226207
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81990394
50neural tube formation (GO:0001841)3.80947659
51tryptophan metabolic process (GO:0006568)3.79966636
52NIK/NF-kappaB signaling (GO:0038061)3.79808336
53positive regulation of interleukin-12 production (GO:0032735)3.77234492
54respiratory burst (GO:0045730)3.75614085
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74870026
56antigen receptor-mediated signaling pathway (GO:0050851)3.74300480
57regulation of alpha-beta T cell proliferation (GO:0046640)3.70408834
58positive regulation of interferon-beta production (GO:0032728)3.69349923
59positive regulation of B cell proliferation (GO:0030890)3.67579407
60establishment of protein localization to Golgi (GO:0072600)3.67364715
61regulation of establishment of cell polarity (GO:2000114)3.64104538
62protein K63-linked deubiquitination (GO:0070536)3.63577554
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61523604
64kynurenine metabolic process (GO:0070189)3.59573329
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57457033
66lymphocyte proliferation (GO:0046651)3.57293852
67mononuclear cell proliferation (GO:0032943)3.54709765
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53202609
69positive regulation of interleukin-2 production (GO:0032743)3.52750935
70response to protozoan (GO:0001562)3.51362680
71cellular response to ethanol (GO:0071361)3.48266770
72regulation of pigment cell differentiation (GO:0050932)3.47051246
73positive regulation of B cell activation (GO:0050871)3.41778033
74immune response-activating cell surface receptor signaling pathway (GO:0002429)3.41370879
75positive regulation of antigen processing and presentation (GO:0002579)3.40370367
76regulation of sarcomere organization (GO:0060297)3.38417753
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38362836
78positive regulation of toll-like receptor signaling pathway (GO:0034123)3.36341159
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36123067
80regulation of B cell activation (GO:0050864)3.35367112
81mature B cell differentiation involved in immune response (GO:0002313)3.35012743
82lymph node development (GO:0048535)3.34175998
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34003987
84response to host immune response (GO:0052572)3.34003987
85positive regulation of cytokine biosynthetic process (GO:0042108)3.33194039
86interferon-gamma-mediated signaling pathway (GO:0060333)3.32578602
87cellular response to exogenous dsRNA (GO:0071360)3.31545161
88lymphocyte homeostasis (GO:0002260)3.31525094
89tachykinin receptor signaling pathway (GO:0007217)3.30882270
90negative regulation of mast cell activation (GO:0033004)3.30492509
91immunoglobulin mediated immune response (GO:0016064)3.29041984
92* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26773672
93positive T cell selection (GO:0043368)3.26011248
94histone H3-K9 modification (GO:0061647)3.24996132
95regulation of interleukin-12 production (GO:0032655)3.22990566
96germinal center formation (GO:0002467)3.22871092
97leukocyte aggregation (GO:0070486)3.22813729
98histone H3-K9 methylation (GO:0051567)3.19187875
99leukocyte proliferation (GO:0070661)3.15148524
100thymic T cell selection (GO:0045061)3.14389807
101neutrophil activation (GO:0042119)3.13718524
102T cell selection (GO:0045058)3.12838005
103B cell differentiation (GO:0030183)3.12143978
104response to host (GO:0075136)3.12139833
105response to host defenses (GO:0052200)3.12139833
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12139833
107interferon-gamma production (GO:0032609)3.10970721
108phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09922682
109snRNA transcription (GO:0009301)3.05722821
110regulation of establishment or maintenance of cell polarity (GO:0032878)3.04867618
111positive regulation of interleukin-10 production (GO:0032733)3.03937012
112regulation of B cell apoptotic process (GO:0002902)3.03520897
113positive regulation of macrophage cytokine production (GO:0060907)3.02486017
114negative regulation of toll-like receptor signaling pathway (GO:0034122)3.02312815
115regulation of interferon-beta production (GO:0032648)2.98505837
116negative thymic T cell selection (GO:0045060)2.97581178
117regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.95989194
118positive regulation of immunoglobulin production (GO:0002639)2.95420463
119superoxide anion generation (GO:0042554)2.94882338
120T cell homeostasis (GO:0043029)2.93162186
121NAD biosynthetic process (GO:0009435)2.92261686
122CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.91998334
123interkinetic nuclear migration (GO:0022027)2.91553186
124regulation of MHC class I biosynthetic process (GO:0045343)2.91543186
125granulocyte activation (GO:0036230)2.89714569
126detection of light stimulus involved in sensory perception (GO:0050962)2.88790826
127detection of light stimulus involved in visual perception (GO:0050908)2.88790826
128histone H3-K4 trimethylation (GO:0080182)2.88428646
129T cell migration (GO:0072678)2.87723805
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87476349
131negative regulation of histone methylation (GO:0031061)2.85930770
132regulation of RIG-I signaling pathway (GO:0039535)2.85881826
133regulation of antigen processing and presentation (GO:0002577)2.85289562
134indole-containing compound metabolic process (GO:0042430)2.84672956
135regulation of hippo signaling (GO:0035330)2.84594732
136regulation of T cell receptor signaling pathway (GO:0050856)2.83911571
137positive regulation of type 2 immune response (GO:0002830)2.83601129
138negative regulation of bone resorption (GO:0045779)2.82059679
139flavonoid metabolic process (GO:0009812)2.80272794
140thyroid hormone metabolic process (GO:0042403)2.80163315
141cellular biogenic amine catabolic process (GO:0042402)2.77391605
142amine catabolic process (GO:0009310)2.77391605
143disruption of cells of other organism (GO:0044364)2.76450717
144killing of cells of other organism (GO:0031640)2.76450717
145regulation of MHC class II biosynthetic process (GO:0045346)2.76095973
146reflex (GO:0060004)2.72530968
147photoreceptor cell maintenance (GO:0045494)2.71477437
148cytoplasmic mRNA processing body assembly (GO:0033962)2.69106335
149negative regulation of T-helper cell differentiation (GO:0045623)2.69036687
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69036687
151response to type I interferon (GO:0034340)2.64274320
152negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60014597
153type I interferon signaling pathway (GO:0060337)2.57974531
154cellular response to type I interferon (GO:0071357)2.57974531
155protein targeting to Golgi (GO:0000042)2.57394599
156sphingoid metabolic process (GO:0046519)2.56274112
157positive regulation of granulocyte differentiation (GO:0030854)2.55746467
158regulation of memory T cell differentiation (GO:0043380)2.54557069
159negative T cell selection (GO:0043383)2.54471053
160production of molecular mediator involved in inflammatory response (GO:0002532)2.53971978
161striated muscle atrophy (GO:0014891)2.52628830
162cytokine biosynthetic process (GO:0042089)2.48822355
163regulation of gene silencing by miRNA (GO:0060964)2.46015385
164regulation of gene silencing by RNA (GO:0060966)2.46015385
165regulation of posttranscriptional gene silencing (GO:0060147)2.46015385
166fucose catabolic process (GO:0019317)2.45881844
167L-fucose metabolic process (GO:0042354)2.45881844
168L-fucose catabolic process (GO:0042355)2.45881844
169activated T cell proliferation (GO:0050798)2.45581094
170hepatocyte apoptotic process (GO:0097284)2.44335961
171benzene-containing compound metabolic process (GO:0042537)2.44278847
172negative regulation of B cell mediated immunity (GO:0002713)2.43887981
173negative regulation of immunoglobulin mediated immune response (GO:0002890)2.43887981
174sulfation (GO:0051923)2.42624228
175regulation of membrane lipid distribution (GO:0097035)2.39972248
176positive regulation of defense response to virus by host (GO:0002230)2.38803084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.79774190
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.54295796
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.18008258
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.43804388
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.42470135
6MYC_22102868_ChIP-Seq_BL_Human3.91507070
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76499863
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.72348258
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.56763423
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41697836
11GBX2_23144817_ChIP-Seq_PC3_Human3.19614417
12E2F7_22180533_ChIP-Seq_HELA_Human3.07294459
13NOTCH1_21737748_ChIP-Seq_TLL_Human3.05854895
14VDR_21846776_ChIP-Seq_THP-1_Human2.98550616
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93856368
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.85112087
17EZH2_22144423_ChIP-Seq_EOC_Human2.82663317
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.79247950
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77977119
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70267944
21RUNX_20019798_ChIP-Seq_JUKART_Human2.68615959
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58574612
23MYB_26560356_Chip-Seq_TH1_Human2.43902812
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42712110
25MYB_26560356_Chip-Seq_TH2_Human2.41092992
26VDR_22108803_ChIP-Seq_LS180_Human2.39870651
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32805332
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32128699
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31832299
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27273862
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.25519720
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24306782
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22992349
34ZNF274_21170338_ChIP-Seq_K562_Hela2.21246583
35IGF1R_20145208_ChIP-Seq_DFB_Human2.18313432
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.17874812
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16811863
38VDR_24763502_ChIP-Seq_THP-1_Human2.14477758
39SPI1_23547873_ChIP-Seq_NB4_Human2.13053548
40MAF_26560356_Chip-Seq_TH1_Human2.04850759
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04815136
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01701741
43TAF15_26573619_Chip-Seq_HEK293_Human2.00859560
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95272852
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94131610
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91525026
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.91128629
48UTX_26944678_Chip-Seq_JUKART_Human1.86085579
49STAT3_23295773_ChIP-Seq_U87_Human1.84514592
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83455333
51ER_23166858_ChIP-Seq_MCF-7_Human1.83114887
52SCL_19346495_ChIP-Seq_HPC-7_Human1.79405864
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79223421
54BCAT_22108803_ChIP-Seq_LS180_Human1.72789693
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72620879
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.70711768
57GATA1_22025678_ChIP-Seq_K562_Human1.69455241
58AR_21572438_ChIP-Seq_LNCaP_Human1.69311715
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68254636
60CIITA_25753668_ChIP-Seq_RAJI_Human1.68223945
61TCF4_23295773_ChIP-Seq_U87_Human1.64314658
62DROSHA_22980978_ChIP-Seq_HELA_Human1.64188152
63P300_19829295_ChIP-Seq_ESCs_Human1.63486452
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62851090
65TCF7_22412390_ChIP-Seq_EML_Mouse1.60373927
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.59916373
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59068846
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56048261
69SMAD4_21799915_ChIP-Seq_A2780_Human1.55784353
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55201044
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.54982818
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52829061
73SPI1_23127762_ChIP-Seq_K562_Human1.52507672
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50927755
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50867192
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50423778
77* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48623456
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47357858
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.45738349
80AR_25329375_ChIP-Seq_VCAP_Human1.44569040
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43828094
82EWS_26573619_Chip-Seq_HEK293_Human1.43658545
83TP53_16413492_ChIP-PET_HCT116_Human1.42649521
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41740890
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.40735314
86FUS_26573619_Chip-Seq_HEK293_Human1.39521034
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38235414
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38235414
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.37682855
90MAF_26560356_Chip-Seq_TH2_Human1.37371524
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37241295
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37209417
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35556538
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33588013
95CBP_20019798_ChIP-Seq_JUKART_Human1.33029306
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33029306
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32538716
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31907165
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.31413977
100GATA3_27048872_Chip-Seq_THYMUS_Human1.29237031
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27020521
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26568717
103KDM2B_26808549_Chip-Seq_DND41_Human1.25066825
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25023424
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.24000687
106PU_27001747_Chip-Seq_BMDM_Mouse1.22826906
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22365731
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.20267752
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.20263413
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20058193
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.19721317
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19651270
113RUNX2_22187159_ChIP-Seq_PCA_Human1.18584884
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18566442
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18477237
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18018048
117* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17791879
118TCF4_22108803_ChIP-Seq_LS180_Human1.17226948
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16595647
120AHR_22903824_ChIP-Seq_MCF-7_Human1.14621579
121* CDX2_22108803_ChIP-Seq_LS180_Human1.14539369
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.14278537
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.12020904
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11269986
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10339704
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09980352
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09437715
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08793489
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.08341045
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07512446
131VDR_24787735_ChIP-Seq_THP-1_Human1.07442299
132KDM2B_26808549_Chip-Seq_REH_Human1.07436192
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06721002
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05885135
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04913941
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04721378
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03370183
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02842994
139E2F1_18555785_Chip-Seq_ESCs_Mouse1.01512409
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00833616
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00381649
142P53_22387025_ChIP-Seq_ESCs_Mouse1.00342285
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99730481
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99565174
145TP63_19390658_ChIP-ChIP_HaCaT_Human0.98685364
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96572618
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.96096545
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96068995
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.95554406
150* GATA3_26560356_Chip-Seq_TH2_Human0.95411998
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94901842
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93692649
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93574795
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.90662866
155SMRT_27268052_Chip-Seq_Bcells_Human0.82710600
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.82404811
157RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82151659
158GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80767658
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.79545832
160ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78973562
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78696939
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77630269
163MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75766257
164CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73044457
165GATA3_26560356_Chip-Seq_TH1_Human0.72672743
166* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71867053
167SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71272517
168CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70999961
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70035510
170ERG_20887958_ChIP-Seq_HPC-7_Mouse0.68926323
171ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.66266546
172E2F4_17652178_ChIP-ChIP_JURKAT_Human0.65186832
173P300_27268052_Chip-Seq_Bcells_Human0.64726383
174STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64282738
175CTCF_26484167_Chip-Seq_Bcells_Mouse0.64093680
176STAT1_20625510_ChIP-Seq_HELA_Human0.64058041
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63712415
178FOXP3_21729870_ChIP-Seq_TREG_Human0.62840890
179HOXB4_20404135_ChIP-ChIP_EML_Mouse0.61869573
180NCOR1_26117541_ChIP-Seq_K562_Human0.60477777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.93707448
2MP0001800_abnormal_humoral_immune5.02742585
3MP0005387_immune_system_phenotype5.01964381
4MP0001790_abnormal_immune_system5.01964381
5MP0002452_abnormal_antigen_presenting3.92856718
6MP0005000_abnormal_immune_tolerance3.81464565
7MP0000685_abnormal_immune_system3.76991781
8MP0003303_peritoneal_inflammation3.67108897
9MP0002723_abnormal_immune_serum3.31030837
10MP0002420_abnormal_adaptive_immunity3.16045580
11MP0001819_abnormal_immune_cell3.05766612
12MP0005671_abnormal_response_to2.91330817
13MP0002398_abnormal_bone_marrow2.76324178
14MP0000716_abnormal_immune_system2.62411964
15MP0000689_abnormal_spleen_morphology2.42027178
16MP0005025_abnormal_response_to2.41150941
17MP0002419_abnormal_innate_immunity2.34169650
18MP0003183_abnormal_peptide_metabolism2.26143648
19MP0001873_stomach_inflammation2.23186571
20MP0003763_abnormal_thymus_physiology2.19898671
21MP0002148_abnormal_hypersensitivity_rea2.13578946
22MP0009785_altered_susceptibility_to2.12654268
23MP0002429_abnormal_blood_cell2.11022851
24MP0001501_abnormal_sleep_pattern2.08353908
25MP0004043_abnormal_pH_regulation1.99432368
26MP0002722_abnormal_immune_system1.97606593
27MP0000372_irregular_coat_pigmentation1.93619012
28MP0005075_abnormal_melanosome_morpholog1.93267051
29MP0003436_decreased_susceptibility_to1.92916875
30MP0003195_calcinosis1.89682826
31MP0003646_muscle_fatigue1.87862425
32MP0001845_abnormal_inflammatory_respons1.86240841
33MP0008877_abnormal_DNA_methylation1.83743997
34MP0005551_abnormal_eye_electrophysiolog1.75829825
35MP0002396_abnormal_hematopoietic_system1.74366136
36MP0004510_myositis1.71119655
37MP0002405_respiratory_system_inflammati1.70437313
38MP0010155_abnormal_intestine_physiology1.64392923
39MP0009046_muscle_twitch1.62671283
40MP0005310_abnormal_salivary_gland1.61648376
41MP0004381_abnormal_hair_follicle1.61553217
42MP0002166_altered_tumor_susceptibility1.60265993
43MP0008057_abnormal_DNA_replication1.60180934
44MP0003252_abnormal_bile_duct1.53699012
45MP0001968_abnormal_touch/_nociception1.49701940
46MP0004947_skin_inflammation1.49403791
47MP0003300_gastrointestinal_ulcer1.48029101
48MP0001853_heart_inflammation1.41383093
49MP0003091_abnormal_cell_migration1.38046196
50MP0000569_abnormal_digit_pigmentation1.32197629
51MP0002006_tumorigenesis1.30393478
52MP0009333_abnormal_splenocyte_physiolog1.30098285
53MP0000427_abnormal_hair_cycle1.29706243
54MP0006082_CNS_inflammation1.29422989
55MP0005645_abnormal_hypothalamus_physiol1.28764294
56MP0005670_abnormal_white_adipose1.28544989
57MP0000703_abnormal_thymus_morphology1.28507099
58MP0005464_abnormal_platelet_physiology1.27005236
59MP0009745_abnormal_behavioral_response1.24732266
60MP0008872_abnormal_physiological_respon1.23011210
61MP0005451_abnormal_body_composition1.21249316
62MP0002736_abnormal_nociception_after1.20355442
63MP0003950_abnormal_plasma_membrane1.19803327
64MP0000465_gastrointestinal_hemorrhage1.19379504
65MP0008260_abnormal_autophagy1.17874713
66MP0008961_abnormal_basal_metabolism1.17836432
67MP0002168_other_aberrant_phenotype1.16833983
68MP0002933_joint_inflammation1.14859587
69MP0004808_abnormal_hematopoietic_stem1.14225205
70MP0009764_decreased_sensitivity_to1.13239710
71MP0002254_reproductive_system_inflammat1.12633603
72MP0003787_abnormal_imprinting1.11054500
73MP0000767_abnormal_smooth_muscle1.10052091
74MP0006054_spinal_hemorrhage1.09873996
75MP0010352_gastrointestinal_tract_polyps1.07769580
76MP0008469_abnormal_protein_level1.06518760
77MP0005174_abnormal_tail_pigmentation1.03997151
78MP0002138_abnormal_hepatobiliary_system1.01930774
79MP0002136_abnormal_kidney_physiology0.99635742
80MP0000015_abnormal_ear_pigmentation0.99092776
81MP0000383_abnormal_hair_follicle0.99089611
82MP0002009_preneoplasia0.96766708
83MP0004142_abnormal_muscle_tone0.96757371
84MP0003866_abnormal_defecation0.92759154
85MP0005253_abnormal_eye_physiology0.91487148
86MP0002735_abnormal_chemical_nociception0.90219953
87MP0003724_increased_susceptibility_to0.89237173
88MP0003077_abnormal_cell_cycle0.87983210
89MP0004145_abnormal_muscle_electrophysio0.85998330
90MP0005166_decreased_susceptibility_to0.85928183
91MP0001486_abnormal_startle_reflex0.85440949
92MP0002928_abnormal_bile_duct0.84680835
93MP0010094_abnormal_chromosome_stability0.83662452
94MP0002067_abnormal_sensory_capabilities0.83047640
95MP0000490_abnormal_crypts_of0.82206380
96MP0002064_seizures0.81846220
97MP0002019_abnormal_tumor_incidence0.81282923
98MP0005647_abnormal_sex_gland0.80732668
99MP0005266_abnormal_metabolism0.79058963
100MP0001663_abnormal_digestive_system0.78487956
101MP0005076_abnormal_cell_differentiation0.76308325
102MP0001485_abnormal_pinna_reflex0.75868478
103MP0001533_abnormal_skeleton_physiology0.75390742
104MP0003693_abnormal_embryo_hatching0.75034520
105MP0000230_abnormal_systemic_arterial0.74721716
106MP0001348_abnormal_lacrimal_gland0.73214749
107MP0001879_abnormal_lymphatic_vessel0.72980778
108MP0003045_fibrosis0.72503653
109MP0003828_pulmonary_edema0.72411888
110MP0004924_abnormal_behavior0.72354540
111MP0005386_behavior/neurological_phenoty0.72354540
112MP0005085_abnormal_gallbladder_physiolo0.71475916
113MP0003111_abnormal_nucleus_morphology0.71370548
114MP0008874_decreased_physiological_sensi0.70909864
115MP0002876_abnormal_thyroid_physiology0.69847265
116MP0005257_abnormal_intraocular_pressure0.69242984
117MP0005621_abnormal_cell_physiology0.69161759
118MP0003172_abnormal_lysosome_physiology0.66525009
119MP0001764_abnormal_homeostasis0.66107005
120MP0003448_altered_tumor_morphology0.66064753
121MP0005395_other_phenotype0.65380693
122MP0005646_abnormal_pituitary_gland0.64566795
123MP0001970_abnormal_pain_threshold0.62244406
124MP0002733_abnormal_thermal_nociception0.62199041
125MP0002095_abnormal_skin_pigmentation0.61853960
126MP0009115_abnormal_fat_cell0.61717484
127MP0002229_neurodegeneration0.61649196
128MP0000249_abnormal_blood_vessel0.60188368
129MP0003633_abnormal_nervous_system0.59910347
130MP0005167_abnormal_blood-brain_barrier0.59139732
131MP0002139_abnormal_hepatobiliary_system0.59015847
132MP0008058_abnormal_DNA_repair0.57460391
133MP0002693_abnormal_pancreas_physiology0.52560313
134MP0000371_diluted_coat_color0.51866295
135MP0003453_abnormal_keratinocyte_physiol0.49728716
136MP0001986_abnormal_taste_sensitivity0.49298466
137MP0009278_abnormal_bone_marrow0.48314808
138MP0000858_altered_metastatic_potential0.47620307
139MP0000350_abnormal_cell_proliferation0.46027874
140MP0002277_abnormal_respiratory_mucosa0.45337656
141MP0002909_abnormal_adrenal_gland0.44882706
142MP0000313_abnormal_cell_death0.44188771
143MP0002998_abnormal_bone_remodeling0.43596025
144MP0009763_increased_sensitivity_to0.42294026
145MP0003566_abnormal_cell_adhesion0.41706426
146MP0003191_abnormal_cellular_cholesterol0.41325631
147MP0005384_cellular_phenotype0.40129571
148MP0001186_pigmentation_phenotype0.37756198
149MP0005390_skeleton_phenotype0.37208538

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)8.25059860
2Agammaglobulinemia (HP:0004432)8.17525805
3Recurrent sinusitis (HP:0011108)6.46115770
4Colitis (HP:0002583)5.90955788
5Cellulitis (HP:0100658)5.68656978
6Recurrent bronchitis (HP:0002837)5.52936088
7IgM deficiency (HP:0002850)5.44115909
8Emphysema (HP:0002097)5.08865549
9Recurrent abscess formation (HP:0002722)5.01993023
10Inflammation of the large intestine (HP:0002037)4.98266027
11Recurrent bacterial skin infections (HP:0005406)4.97610249
12Recurrent viral infections (HP:0004429)4.93500928
13Lymphopenia (HP:0001888)4.86402960
14IgA deficiency (HP:0002720)4.81033931
15Gastrointestinal inflammation (HP:0004386)4.66708762
16Vasculitis (HP:0002633)4.61127172
17Abnormality of cells of the lymphoid lineage (HP:0012140)4.56204043
18Meningitis (HP:0001287)4.53218700
19Genetic anticipation (HP:0003743)4.51705235
20Mediastinal lymphadenopathy (HP:0100721)4.51286470
21Abnormal delayed hypersensitivity skin test (HP:0002963)4.16875753
22Eczematoid dermatitis (HP:0000976)4.09138837
23Hyperventilation (HP:0002883)4.08785376
24Recurrent pneumonia (HP:0006532)4.06879069
25Papilloma (HP:0012740)4.06096334
26Verrucae (HP:0200043)4.06096334
27Chronic sinusitis (HP:0011109)4.04565550
28Panhypogammaglobulinemia (HP:0003139)3.93608308
29Chronic diarrhea (HP:0002028)3.91799690
30Restrictive lung disease (HP:0002091)3.91509136
31Gaze-evoked nystagmus (HP:0000640)3.90540017
32Chronic otitis media (HP:0000389)3.82205150
33Recurrent lower respiratory tract infections (HP:0002783)3.70093497
34Recurrent fungal infections (HP:0002841)3.62767649
35Progressive cerebellar ataxia (HP:0002073)3.56776781
36Osteomyelitis (HP:0002754)3.54416695
37Recurrent skin infections (HP:0001581)3.50019630
38Pancreatic cysts (HP:0001737)3.49331541
39Small epiphyses (HP:0010585)3.47502029
40Leukopenia (HP:0001882)3.34448128
41Congenital stationary night blindness (HP:0007642)3.32739554
42Recurrent otitis media (HP:0000403)3.29086552
43Recurrent cutaneous fungal infections (HP:0011370)3.24033217
44Chronic mucocutaneous candidiasis (HP:0002728)3.24033217
45Recurrent gram-negative bacterial infections (HP:0005420)3.19890821
46Chronic obstructive pulmonary disease (HP:0006510)3.13775455
47Obstructive lung disease (HP:0006536)3.13775455
48Clumsiness (HP:0002312)3.09199794
49Bronchitis (HP:0012387)3.05383522
50Attenuation of retinal blood vessels (HP:0007843)3.03537350
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.01192259
52Protruding tongue (HP:0010808)2.99746728
53Congenital sensorineural hearing impairment (HP:0008527)2.92471420
54B lymphocytopenia (HP:0010976)2.90699986
55Abnormality of B cell number (HP:0010975)2.90699986
56Prostate neoplasm (HP:0100787)2.81303358
57True hermaphroditism (HP:0010459)2.78997129
58Sepsis (HP:0100806)2.78442837
59Pancreatic fibrosis (HP:0100732)2.78279696
60Lymphoma (HP:0002665)2.78099590
61Stomach cancer (HP:0012126)2.77274557
62Abnormality of the prostate (HP:0008775)2.77236716
63Pulmonary infiltrates (HP:0002113)2.72006718
64Chronic hepatic failure (HP:0100626)2.71161479
65Absent speech (HP:0001344)2.68139423
66Abnormality of the fingertips (HP:0001211)2.66481598
67Febrile seizures (HP:0002373)2.57212133
68Pustule (HP:0200039)2.56301232
69Nasal polyposis (HP:0100582)2.55978316
70Interstitial pulmonary disease (HP:0006530)2.55952253
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.55363442
72Viral hepatitis (HP:0006562)2.51921980
73Fair hair (HP:0002286)2.47709132
74IgG deficiency (HP:0004315)2.44603047
75Anomalous pulmonary venous return (HP:0010772)2.42376813
76Abnormality of the intervertebral disk (HP:0005108)2.41813875
77Bony spicule pigmentary retinopathy (HP:0007737)2.41545737
78Mitral stenosis (HP:0001718)2.39198776
79Abnormality of the renal cortex (HP:0011035)2.36757834
80Stomatitis (HP:0010280)2.36368362
81Abnormality of T cell physiology (HP:0011840)2.32999731
82Gingivitis (HP:0000230)2.30992733
83Abnormality of T cells (HP:0002843)2.28063404
84Thyroiditis (HP:0100646)2.27233419
85Arthralgia (HP:0002829)2.27098831
86Encephalitis (HP:0002383)2.24606815
87Abolished electroretinogram (ERG) (HP:0000550)2.21564625
88Skin ulcer (HP:0200042)2.20525486
89Cystic liver disease (HP:0006706)2.20093644
90Decreased circulating renin level (HP:0003351)2.19312162
91Hematochezia (HP:0002573)2.19098607
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19021433
93Dysmetric saccades (HP:0000641)2.19014888
94Autoimmune thrombocytopenia (HP:0001973)2.18100590
95Abnormality of macrophages (HP:0004311)2.16596654
96Flattened epiphyses (HP:0003071)2.16250547
97Abnormality of midbrain morphology (HP:0002418)2.13453272
98Molar tooth sign on MRI (HP:0002419)2.13453272
99Facial diplegia (HP:0001349)2.12717327
100Widely spaced teeth (HP:0000687)2.10023477
101Thrombocytosis (HP:0001894)2.09752595
102Abnormality of the renal medulla (HP:0100957)2.08126055
103Nephronophthisis (HP:0000090)2.06003146
104Periodontitis (HP:0000704)2.05484224
105Abnormality of the pulmonary veins (HP:0011718)2.05427305
106Generalized hypopigmentation of hair (HP:0011358)2.04541466
107Dialeptic seizures (HP:0011146)2.04416683
108Hypoplastic ischia (HP:0003175)2.04171701
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02406487
110Abnormality of the nasal mucosa (HP:0000433)2.02357071
111Central scotoma (HP:0000603)2.01985035
112Abnormality of male internal genitalia (HP:0000022)2.01769199
113T lymphocytopenia (HP:0005403)2.01033522
114Myositis (HP:0100614)1.99063479
115Neutropenia (HP:0001875)1.95189681
116Abnormality of T cell number (HP:0011839)1.93874659
117Spontaneous hematomas (HP:0007420)1.92191664
118Increased corneal curvature (HP:0100692)1.92070479
119Keratoconus (HP:0000563)1.92070479
120Focal seizures (HP:0007359)1.91928429
121Irregular vertebral endplates (HP:0003301)1.90678905
122Retrobulbar optic neuritis (HP:0100654)1.88128300
123Optic neuritis (HP:0100653)1.88128300
124Progressive inability to walk (HP:0002505)1.88036745
125Fatigue (HP:0012378)1.87938070
126Inability to walk (HP:0002540)1.87514597
127Myocardial infarction (HP:0001658)1.87200861
128Hemoptysis (HP:0002105)1.87166675
129Xerostomia (HP:0000217)1.85866885
130Acrocyanosis (HP:0001063)1.85585970
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.85322161
132Increased cerebral lipofuscin (HP:0011813)1.85168572
133Keratoconjunctivitis (HP:0001096)1.84197091
134Skin rash (HP:0000988)1.82844362
135Increased IgE level (HP:0003212)1.81137084
136Abnormality of the ischium (HP:0003174)1.80395785
137Urticaria (HP:0001025)1.80057279
138Medial flaring of the eyebrow (HP:0010747)1.78344185
139Poikiloderma (HP:0001029)1.78340957
140Bile duct proliferation (HP:0001408)1.78243447
141Abnormal biliary tract physiology (HP:0012439)1.78243447
142Vertebral arch anomaly (HP:0008438)1.78169127
143Absence seizures (HP:0002121)1.78139383
144Abnormality of binocular vision (HP:0011514)1.77692101
145Diplopia (HP:0000651)1.77692101
146Albinism (HP:0001022)1.77260030
147Chest pain (HP:0100749)1.76188208
148Abnormality of DNA repair (HP:0003254)1.74234243
149Arterial thrombosis (HP:0004420)1.73979527
150Bronchiectasis (HP:0002110)1.72639839
151Absent epiphyses (HP:0010577)1.71594581
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71594581
153Clubbing of toes (HP:0100760)1.65049646
154Abnormality of the vertebral endplates (HP:0005106)1.56880942
155Hepatitis (HP:0012115)1.55076002
156Basal ganglia calcification (HP:0002135)1.50828741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.57170118
2MAP4K16.84608084
3CDK123.63746571
4BLK3.60470476
5CSF1R2.95182491
6IRAK32.91196802
7ERN12.84651856
8JAK12.81460807
9ACVR1B2.76442625
10MAP3K142.65170433
11MAP3K132.48560770
12RIPK42.47752260
13TYK22.36630957
14SYK2.34180864
15BTK2.33673536
16BRD42.26898961
17GRK62.20212541
18STK102.11311037
19SIK21.98732248
20BMPR1B1.93128830
21WNK31.85383699
22IKBKB1.76377318
23LRRK21.74385153
24JAK31.68734323
25EIF2AK31.66319837
26ADRBK21.63764725
27IRAK41.55338763
28MAPK131.48493689
29LYN1.48246357
30SIK31.46933872
31MKNK21.45849234
32KIT1.42942230
33GRK11.41741473
34HCK1.41728150
35TBK11.38808543
36PIK3CG1.38306133
37FES1.37488919
38NTRK31.35715360
39IRAK11.34935641
40CSK1.30371659
41OXSR11.27721475
42TEC1.24515281
43MARK31.22541303
44MST41.18426944
45ALK1.12817212
46PIM11.10203223
47STK38L1.07743024
48MAP3K101.07088659
49PTK2B0.99679999
50INSRR0.98888927
51PRKCQ0.95924891
52MAP4K20.95528204
53ZAK0.93814868
54CHUK0.92955949
55IKBKE0.91970311
56MKNK10.90738900
57MAP3K90.90519924
58ADRBK10.88295273
59CDK90.87046633
60ITK0.86399248
61LCK0.86043273
62MATK0.84915794
63BMPR20.80595124
64TNK20.80529177
65SGK20.78725891
66FGR0.78232770
67TRPM70.77484315
68NEK20.77177063
69ZAP700.76051785
70CASK0.74585286
71STK30.71326716
72MAPK110.70342776
73PINK10.70327988
74RPS6KA40.69875574
75MAPK70.68365483
76CDK190.67847883
77FER0.66265866
78STK40.65312892
79STK240.64175788
80PRKAA20.63682850
81TGFBR20.63070198
82FGFR30.61295676
83PRKCH0.60673928
84CLK10.59444073
85CDC42BPA0.58078238
86TGFBR10.58048468
87PAK30.57432908
88ABL10.56921948
89TAOK30.55184934
90PRKD20.55090429
91PDK10.54761589
92CDK40.53955837
93EEF2K0.52157463
94YES10.50964399
95AKT30.50782724
96HIPK20.50744038
97PKN10.49698398
98FGFR40.48250428
99NLK0.47358375
100MELK0.47353134
101PRKCE0.45112024
102MAP3K40.44502862
103TXK0.41911922
104INSR0.41473762
105STK390.39684645
106SIK10.38622825
107MAPKAPK30.37685951
108LATS10.37505732
109EPHA30.37291862
110JAK20.36981108
111BRSK20.35656949
112GRK50.35619673
113CAMK1G0.35284000
114EGFR0.34727593
115FYN0.34685041
116PIK3CA0.33933068
117CAMK1D0.33748764
118EIF2AK20.32274829
119EPHB10.31789777
120PRKAA10.31699867
121MAPK120.31553763
122PRKCZ0.30942028
123STK110.30605277
124PRKCD0.29098718
125PRKCB0.27845437
126SRPK10.25800601
127DYRK1A0.25405901
128SGK30.25386297
129ATR0.25091235
130PRKD10.24622793
131WNK10.21667659
132MAP3K70.21535138
133NUAK10.21195177
134TAOK20.20494608
135CHEK10.18463346
136MAPK30.18212366
137CDK60.17491697
138CSNK1A10.16424879
139MAP3K80.15807047

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046625.51110650
2Primary immunodeficiency_Homo sapiens_hsa053404.97029021
3Hematopoietic cell lineage_Homo sapiens_hsa046403.56857925
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.41713448
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.09645460
6Leishmaniasis_Homo sapiens_hsa051402.31365519
7Osteoclast differentiation_Homo sapiens_hsa043802.26127228
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16148556
9ABC transporters_Homo sapiens_hsa020101.97024345
10Herpes simplex infection_Homo sapiens_hsa051681.95886054
11Measles_Homo sapiens_hsa051621.89859578
12Antigen processing and presentation_Homo sapiens_hsa046121.89627170
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84362877
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79820933
15Tuberculosis_Homo sapiens_hsa051521.78152484
16T cell receptor signaling pathway_Homo sapiens_hsa046601.67061549
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64331956
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63155549
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61682188
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59117678
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54458287
22Linoleic acid metabolism_Homo sapiens_hsa005911.53680207
23African trypanosomiasis_Homo sapiens_hsa051431.49851572
24Epstein-Barr virus infection_Homo sapiens_hsa051691.48336063
25Malaria_Homo sapiens_hsa051441.48223984
26Phototransduction_Homo sapiens_hsa047441.45858488
27Chemokine signaling pathway_Homo sapiens_hsa040621.45856565
28Butanoate metabolism_Homo sapiens_hsa006501.45311635
29Influenza A_Homo sapiens_hsa051641.37714256
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35508086
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.32671071
32Ether lipid metabolism_Homo sapiens_hsa005651.31484762
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.27613892
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26621907
35Apoptosis_Homo sapiens_hsa042101.23197555
36Hepatitis B_Homo sapiens_hsa051611.22180402
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21083043
38Toxoplasmosis_Homo sapiens_hsa051451.20798765
39Tryptophan metabolism_Homo sapiens_hsa003801.19430401
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17218920
41TNF signaling pathway_Homo sapiens_hsa046681.15455326
42Allograft rejection_Homo sapiens_hsa053301.13696036
43Legionellosis_Homo sapiens_hsa051341.10805071
44Graft-versus-host disease_Homo sapiens_hsa053321.08216960
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.07764533
46Nicotine addiction_Homo sapiens_hsa050331.05103847
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03019883
48Non-homologous end-joining_Homo sapiens_hsa034501.02728466
49Pertussis_Homo sapiens_hsa051331.00459336
50Olfactory transduction_Homo sapiens_hsa047400.99808892
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98771595
52Glycerolipid metabolism_Homo sapiens_hsa005610.97525990
53Staphylococcus aureus infection_Homo sapiens_hsa051500.92013201
54Morphine addiction_Homo sapiens_hsa050320.91136017
55Taste transduction_Homo sapiens_hsa047420.89199829
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87882618
57Salivary secretion_Homo sapiens_hsa049700.87468919
58Calcium signaling pathway_Homo sapiens_hsa040200.87413711
59Acute myeloid leukemia_Homo sapiens_hsa052210.87386501
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87031098
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.85680090
62Nitrogen metabolism_Homo sapiens_hsa009100.84869592
63Serotonergic synapse_Homo sapiens_hsa047260.84844903
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82493526
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.80773037
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80555546
67Chronic myeloid leukemia_Homo sapiens_hsa052200.79771366
68Non-small cell lung cancer_Homo sapiens_hsa052230.78967438
69Long-term depression_Homo sapiens_hsa047300.77272599
70Rheumatoid arthritis_Homo sapiens_hsa053230.76828377
71Hepatitis C_Homo sapiens_hsa051600.75120025
72Viral carcinogenesis_Homo sapiens_hsa052030.74829212
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.74264599
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.72705197
75Shigellosis_Homo sapiens_hsa051310.70755726
76Autoimmune thyroid disease_Homo sapiens_hsa053200.70612868
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70324598
78Pancreatic cancer_Homo sapiens_hsa052120.69755313
79Glutamatergic synapse_Homo sapiens_hsa047240.69542588
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68285612
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67602167
82Base excision repair_Homo sapiens_hsa034100.66287795
83Platelet activation_Homo sapiens_hsa046110.66260329
84Viral myocarditis_Homo sapiens_hsa054160.66038977
85Other glycan degradation_Homo sapiens_hsa005110.65439548
86Cholinergic synapse_Homo sapiens_hsa047250.65034604
87Arachidonic acid metabolism_Homo sapiens_hsa005900.64678861
88Ovarian steroidogenesis_Homo sapiens_hsa049130.64634430
89Histidine metabolism_Homo sapiens_hsa003400.64108606
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62863303
91Fanconi anemia pathway_Homo sapiens_hsa034600.62569887
92Circadian entrainment_Homo sapiens_hsa047130.60662938
93Systemic lupus erythematosus_Homo sapiens_hsa053220.60377726
94MAPK signaling pathway_Homo sapiens_hsa040100.59777496
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58200186
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57736300
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57500741
98Selenocompound metabolism_Homo sapiens_hsa004500.57246520
99Small cell lung cancer_Homo sapiens_hsa052220.56700114
100Sphingolipid metabolism_Homo sapiens_hsa006000.56266239
101Salmonella infection_Homo sapiens_hsa051320.55372736
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54936324
103Notch signaling pathway_Homo sapiens_hsa043300.54703899
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54055916
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53945999
106p53 signaling pathway_Homo sapiens_hsa041150.53489349
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53218564
108HTLV-I infection_Homo sapiens_hsa051660.52165247
109Type I diabetes mellitus_Homo sapiens_hsa049400.51864514
110Phagosome_Homo sapiens_hsa041450.51558916
111Retinol metabolism_Homo sapiens_hsa008300.51455985
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.51412602
113MicroRNAs in cancer_Homo sapiens_hsa052060.50966321
114Oxytocin signaling pathway_Homo sapiens_hsa049210.50936748
115Ribosome_Homo sapiens_hsa030100.49810753
116Caffeine metabolism_Homo sapiens_hsa002320.49464403
117Inositol phosphate metabolism_Homo sapiens_hsa005620.49152854
118Choline metabolism in cancer_Homo sapiens_hsa052310.48693446
119Lysine degradation_Homo sapiens_hsa003100.46164260
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.45333205
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45186653
122FoxO signaling pathway_Homo sapiens_hsa040680.44631709
123Gastric acid secretion_Homo sapiens_hsa049710.43156661
124cAMP signaling pathway_Homo sapiens_hsa040240.42204006
125Chemical carcinogenesis_Homo sapiens_hsa052040.41873106
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40476174
127Dorso-ventral axis formation_Homo sapiens_hsa043200.39677600
128GABAergic synapse_Homo sapiens_hsa047270.39502448
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.38236407
130mTOR signaling pathway_Homo sapiens_hsa041500.37773434
131Asthma_Homo sapiens_hsa053100.36374944
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.36248062
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34941771
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.34836554
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33707041
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32856382
137HIF-1 signaling pathway_Homo sapiens_hsa040660.31447569
138Homologous recombination_Homo sapiens_hsa034400.31226092
139Prolactin signaling pathway_Homo sapiens_hsa049170.30596011
140Type II diabetes mellitus_Homo sapiens_hsa049300.30393679
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29547019
142Proteoglycans in cancer_Homo sapiens_hsa052050.27618503
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25226252
144Spliceosome_Homo sapiens_hsa030400.24611023
145Prostate cancer_Homo sapiens_hsa052150.24551891
146Colorectal cancer_Homo sapiens_hsa052100.23577685
147N-Glycan biosynthesis_Homo sapiens_hsa005100.23394456
148Glioma_Homo sapiens_hsa052140.23279801
149Insulin resistance_Homo sapiens_hsa049310.23179757
150Mismatch repair_Homo sapiens_hsa034300.22567089
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21919909
152RNA degradation_Homo sapiens_hsa030180.21364618
153Lysosome_Homo sapiens_hsa041420.21291287

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