FCRLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.69156443
2positive regulation of gamma-delta T cell activation (GO:0046645)8.02343087
3positive regulation of B cell differentiation (GO:0045579)6.82268537
4antigen processing and presentation of endogenous antigen (GO:0019883)6.50152205
5regulation of B cell differentiation (GO:0045577)6.22448046
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.06628182
7regulation of gamma-delta T cell differentiation (GO:0045586)6.04723383
8regulation of B cell receptor signaling pathway (GO:0050855)5.88631251
9cellular response to zinc ion (GO:0071294)5.71902831
10regulation of gamma-delta T cell activation (GO:0046643)5.57819315
11regulation of superoxide anion generation (GO:0032928)5.10533826
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04767585
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04767585
14B cell proliferation (GO:0042100)5.01076300
15serine transport (GO:0032329)4.91944291
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.84494945
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.84494945
18modulation by symbiont of host immune response (GO:0052553)4.84494945
19positive regulation by symbiont of host defense response (GO:0052509)4.84494945
20modulation by symbiont of host defense response (GO:0052031)4.84494945
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.84494945
22CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.70838139
23L-serine transport (GO:0015825)4.46385058
24negative regulation of B cell proliferation (GO:0030889)4.42415417
25cytidine deamination (GO:0009972)4.39554780
26cytidine metabolic process (GO:0046087)4.39554780
27cytidine catabolic process (GO:0006216)4.39554780
28B cell mediated immunity (GO:0019724)4.36717739
29regulation of B cell proliferation (GO:0030888)4.29347391
30neutrophil activation (GO:0042119)4.28058993
31regulation of histone H3-K9 methylation (GO:0051570)4.25635658
32mature B cell differentiation (GO:0002335)4.24174010
33antigen receptor-mediated signaling pathway (GO:0050851)4.15474112
34negative regulation of phagocytosis (GO:0050765)4.13277655
35regulation of antigen processing and presentation (GO:0002577)4.10678897
36positive regulation of interferon-alpha production (GO:0032727)4.09145715
37neutrophil activation involved in immune response (GO:0002283)4.08602495
38negative regulation of histone methylation (GO:0031061)4.06255840
39V(D)J recombination (GO:0033151)4.04895641
40positive thymic T cell selection (GO:0045059)3.99686384
41Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.93367761
42immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.93367761
43Fc-gamma receptor signaling pathway (GO:0038094)3.93367761
44macrophage activation involved in immune response (GO:0002281)3.91203052
45regulation of interferon-gamma biosynthetic process (GO:0045072)3.89854339
46regulation of B cell apoptotic process (GO:0002902)3.89822494
47cellular response to type I interferon (GO:0071357)3.87715114
48type I interferon signaling pathway (GO:0060337)3.87715114
49regulation of platelet aggregation (GO:0090330)3.87446089
50Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.87297505
51immune response-activating cell surface receptor signaling pathway (GO:0002429)3.86865505
52regulation of interferon-beta biosynthetic process (GO:0045357)3.85203621
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84633493
54negative regulation of cell killing (GO:0031342)3.84633493
55response to type I interferon (GO:0034340)3.84251089
56regulation of alpha-beta T cell proliferation (GO:0046640)3.83138570
57regulation of interferon-alpha production (GO:0032647)3.79745222
58detection of bacterium (GO:0016045)3.79209838
59granulocyte activation (GO:0036230)3.79085860
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.76815687
61positive regulation of mast cell degranulation (GO:0043306)3.76815687
62positive T cell selection (GO:0043368)3.74890156
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.74024518
64negative thymic T cell selection (GO:0045060)3.68728534
65T cell migration (GO:0072678)3.65363187
66B cell activation (GO:0042113)3.64375392
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64108249
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.62890733
69T cell lineage commitment (GO:0002360)3.62361200
70positive regulation of cell adhesion mediated by integrin (GO:0033630)3.62340420
71complement activation, classical pathway (GO:0006958)3.61193367
72lymphocyte homeostasis (GO:0002260)3.57473397
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54607762
74T cell selection (GO:0045058)3.53595890
75T cell homeostasis (GO:0043029)3.53330316
76B cell homeostasis (GO:0001782)3.52494888
77detection of other organism (GO:0098543)3.51307487
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.49338817
79germinal center formation (GO:0002467)3.48545509
80negative regulation of bone resorption (GO:0045779)3.48521007
81lymph vessel development (GO:0001945)3.44488631
82negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.44169921
83positive regulation of B cell activation (GO:0050871)3.43553024
84positive regulation of gene expression, epigenetic (GO:0045815)3.40711434
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40349484
86response to host immune response (GO:0052572)3.40349484
87T cell costimulation (GO:0031295)3.39685182
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38324433
89positive regulation of B cell proliferation (GO:0030890)3.37957907
90defense response to protozoan (GO:0042832)3.37476534
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.37045700
92negative T cell selection (GO:0043383)3.36936348
93lymphocyte costimulation (GO:0031294)3.34605791
94B cell differentiation (GO:0030183)3.33234302
95regulation of B cell activation (GO:0050864)3.32913776
96natural killer cell differentiation (GO:0001779)3.30360661
97vesicle targeting (GO:0006903)3.29049260
98hepatocyte apoptotic process (GO:0097284)3.26372779
99regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26199568
100response to protozoan (GO:0001562)3.24732841
101negative regulation of gene silencing (GO:0060969)3.23653959
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.20782825
103antimicrobial humoral response (GO:0019730)3.19431551
104humoral immune response (GO:0006959)3.18707284
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17295416
106antibacterial humoral response (GO:0019731)3.16891480
107mature B cell differentiation involved in immune response (GO:0002313)3.16885084
108positive regulation of immunoglobulin production (GO:0002639)3.15935760
109respiratory burst (GO:0045730)3.14227538
110pyrimidine ribonucleoside catabolic process (GO:0046133)3.14040613
111production of molecular mediator involved in inflammatory response (GO:0002532)3.13824381
112regulation of germinal center formation (GO:0002634)3.13119336
113response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11771740
114response to host (GO:0075136)3.11771740
115response to host defenses (GO:0052200)3.11771740
116Peyers patch development (GO:0048541)3.11426452
117mucosal-associated lymphoid tissue development (GO:0048537)3.11426452
118interferon-gamma-mediated signaling pathway (GO:0060333)3.10713350
119mononuclear cell proliferation (GO:0032943)3.10268894
120regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.09645032
121lymphocyte proliferation (GO:0046651)3.09084203
122regulation of superoxide metabolic process (GO:0090322)3.08804374
123leukocyte homeostasis (GO:0001776)3.07149262
124response to interleukin-15 (GO:0070672)3.05872190
125positive regulation of mast cell activation (GO:0033005)3.03974394
126tolerance induction (GO:0002507)3.03877095
127cellular response to interleukin-15 (GO:0071350)3.01863992
128lymph node development (GO:0048535)3.01608872
129NIK/NF-kappaB signaling (GO:0038061)3.00742363
130positive regulation of histone deacetylation (GO:0031065)3.00341307
131I-kappaB phosphorylation (GO:0007252)2.98483105
132negative regulation of B cell apoptotic process (GO:0002903)2.96437105
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.95872912
134positive regulation of humoral immune response (GO:0002922)2.95775454
135activation of JUN kinase activity (GO:0007257)2.94567934
136positive regulation of type 2 immune response (GO:0002830)2.94363836
137immunoglobulin mediated immune response (GO:0016064)2.93659604
138positive regulation of interferon-beta production (GO:0032728)2.92146715
139cellular response to interferon-gamma (GO:0071346)2.92019275
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89619675
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89131723
142positive regulation of Rap GTPase activity (GO:0032854)2.88998898
143thymic T cell selection (GO:0045061)2.88376970
144positive regulation of protein homooligomerization (GO:0032464)2.87590298
145leukocyte proliferation (GO:0070661)2.86602458
146positive regulation of antigen processing and presentation (GO:0002579)2.86375621
147adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.84236511
148myeloid dendritic cell activation (GO:0001773)2.83833658
149regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77888531
150antigen processing and presentation via MHC class Ib (GO:0002475)2.75673007
151regulation of interferon-beta production (GO:0032648)2.74226877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.10682717
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.93173321
3E2F7_22180533_ChIP-Seq_HELA_Human5.22672572
4MYC_22102868_ChIP-Seq_BL_Human5.06546097
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.42369048
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.28953644
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25838934
8VDR_21846776_ChIP-Seq_THP-1_Human3.62205090
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.55701155
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.30782472
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.15945502
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04692005
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94600582
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.66889149
15RUNX_20019798_ChIP-Seq_JUKART_Human2.64116277
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.62891252
17MAF_26560356_Chip-Seq_TH1_Human2.52490318
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50519368
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.47227242
20MYB_26560356_Chip-Seq_TH2_Human2.43210681
21UTX_26944678_Chip-Seq_JUKART_Human2.33074651
22MYB_26560356_Chip-Seq_TH1_Human2.30984814
23VDR_24763502_ChIP-Seq_THP-1_Human2.20729803
24CIITA_25753668_ChIP-Seq_RAJI_Human2.06860783
25TCF7_22412390_ChIP-Seq_EML_Mouse2.03446719
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00503853
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00051644
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98315618
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97881903
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87469533
31SCL_19346495_ChIP-Seq_HPC-7_Human1.87304324
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86401911
33SPI1_23547873_ChIP-Seq_NB4_Human1.84357993
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83987041
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83506827
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79532218
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79200935
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77855368
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75668512
40KDM2B_26808549_Chip-Seq_DND41_Human1.75172171
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73437140
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.63145877
43SPI1_23127762_ChIP-Seq_K562_Human1.58396766
44MAF_26560356_Chip-Seq_TH2_Human1.50243085
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.48354006
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45775864
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44143633
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42846826
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42421191
50GATA3_27048872_Chip-Seq_THYMUS_Human1.40497994
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36955544
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35663623
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35268094
54* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34938303
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34546244
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33906289
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33478767
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31325399
59GATA1_22025678_ChIP-Seq_K562_Human1.30235650
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27780233
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26775081
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26016445
63* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24361081
64* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22197731
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.22154750
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21092352
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18381868
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16382654
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08977703
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08384604
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.05972161
72FOXP3_21729870_ChIP-Seq_TREG_Human1.03687031
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02744883
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00358235
75VDR_23849224_ChIP-Seq_CD4+_Human0.96422661
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95855239
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95584494
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.93896342
79* PU_27001747_Chip-Seq_BMDM_Mouse0.93862045
80KDM5A_27292631_Chip-Seq_BREAST_Human0.93548970
81P300_27268052_Chip-Seq_Bcells_Human0.89086010
82TFEB_21752829_ChIP-Seq_HELA_Human0.87953395
83* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87531268
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86113191
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.85544101
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85439588
87MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85231558
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.84225787
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84103659
90GATA3_26560356_Chip-Seq_TH2_Human0.84052813
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83566100
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.83352041
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82985237
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82641479
95* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82401286
96* NCOR1_26117541_ChIP-Seq_K562_Human0.82330690
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82016000
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.81903558
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81683105
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81153445
101YY1_21170310_ChIP-Seq_MESCs_Mouse0.80737391
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79947492
103BCL6_27268052_Chip-Seq_Bcells_Human0.79916228
104ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77659914
105SMRT_27268052_Chip-Seq_Bcells_Human0.76659004
106LXR_22292898_ChIP-Seq_THP-1_Human0.74563100
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72160895
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71714150
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.70950039
110BCOR_27268052_Chip-Seq_Bcells_Human0.70540072
111VDR_24787735_ChIP-Seq_THP-1_Human0.70435224
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70228313
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70163656
114GATA3_26560356_Chip-Seq_TH1_Human0.69870035
115SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69184558
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67795690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.52386549
2* MP0001800_abnormal_humoral_immune4.90233063
3MP0001790_abnormal_immune_system4.74832508
4MP0005387_immune_system_phenotype4.74832508
5MP0000685_abnormal_immune_system3.99429399
6MP0003303_peritoneal_inflammation3.99336354
7* MP0002452_abnormal_antigen_presenting3.73648508
8MP0005000_abnormal_immune_tolerance3.08333751
9MP0002398_abnormal_bone_marrow3.06401550
10* MP0002723_abnormal_immune_serum3.04039320
11* MP0002420_abnormal_adaptive_immunity3.02707429
12* MP0001819_abnormal_immune_cell2.95183656
13MP0005671_abnormal_response_to2.93301078
14MP0000689_abnormal_spleen_morphology2.79210686
15MP0000716_abnormal_immune_system2.77368580
16MP0006054_spinal_hemorrhage2.54051899
17MP0002166_altered_tumor_susceptibility2.52397210
18MP0002722_abnormal_immune_system2.34370833
19MP0002429_abnormal_blood_cell2.29106056
20MP0002396_abnormal_hematopoietic_system2.13102289
21MP0003300_gastrointestinal_ulcer2.08883224
22MP0005025_abnormal_response_to2.07414767
23MP0003763_abnormal_thymus_physiology2.03861062
24MP0003436_decreased_susceptibility_to1.96484750
25MP0009785_altered_susceptibility_to1.85693260
26MP0000703_abnormal_thymus_morphology1.85114743
27MP0004808_abnormal_hematopoietic_stem1.83017824
28MP0005075_abnormal_melanosome_morpholog1.78348280
29MP0000372_irregular_coat_pigmentation1.78167846
30MP0002419_abnormal_innate_immunity1.74408983
31MP0002006_tumorigenesis1.73943100
32MP0002148_abnormal_hypersensitivity_rea1.70232076
33MP0002405_respiratory_system_inflammati1.67197939
34MP0010155_abnormal_intestine_physiology1.66782104
35MP0005645_abnormal_hypothalamus_physiol1.65544147
36MP0001879_abnormal_lymphatic_vessel1.64761124
37MP0001845_abnormal_inflammatory_respons1.61758973
38MP0004381_abnormal_hair_follicle1.59421983
39MP0001348_abnormal_lacrimal_gland1.57878198
40MP0004947_skin_inflammation1.53479025
41MP0008057_abnormal_DNA_replication1.49357986
42MP0001873_stomach_inflammation1.48862145
43MP0002933_joint_inflammation1.45213788
44MP0010234_abnormal_vibrissa_follicle1.41240474
45MP0004510_myositis1.40825359
46MP0010094_abnormal_chromosome_stability1.39974855
47MP0003866_abnormal_defecation1.39105548
48MP0001853_heart_inflammation1.37957983
49MP0000465_gastrointestinal_hemorrhage1.37591934
50MP0002019_abnormal_tumor_incidence1.35375858
51MP0003183_abnormal_peptide_metabolism1.24674936
52MP0010352_gastrointestinal_tract_polyps1.21035550
53MP0005310_abnormal_salivary_gland1.17952975
54MP0003077_abnormal_cell_cycle1.17186915
55MP0000371_diluted_coat_color1.13013767
56MP0005464_abnormal_platelet_physiology1.11211591
57MP0001986_abnormal_taste_sensitivity1.09181336
58MP0009333_abnormal_splenocyte_physiolog1.08970895
59MP0002136_abnormal_kidney_physiology1.01804307
60MP0009278_abnormal_bone_marrow0.96226783
61MP0000490_abnormal_crypts_of0.94484965
62MP0005076_abnormal_cell_differentiation0.92452084
63MP0003172_abnormal_lysosome_physiology0.88033517
64MP0003693_abnormal_embryo_hatching0.87315085
65MP0003787_abnormal_imprinting0.86521257
66MP0003724_increased_susceptibility_to0.82912104
67MP0008469_abnormal_protein_level0.80736396
68MP0003111_abnormal_nucleus_morphology0.80262314
69MP0008260_abnormal_autophagy0.80208359
70MP0000350_abnormal_cell_proliferation0.75778734
71MP0003091_abnormal_cell_migration0.75416585
72MP0002095_abnormal_skin_pigmentation0.74616007
73MP0005397_hematopoietic_system_phenotyp0.67569545
74MP0001545_abnormal_hematopoietic_system0.67569545
75MP0002163_abnormal_gland_morphology0.64862227
76MP0003045_fibrosis0.63719647
77MP0002928_abnormal_bile_duct0.63627391
78MP0008961_abnormal_basal_metabolism0.62838345
79MP0000858_altered_metastatic_potential0.62674348
80MP0008058_abnormal_DNA_repair0.61460919
81MP0005621_abnormal_cell_physiology0.60804026
82MP0001663_abnormal_digestive_system0.60623119
83MP0002138_abnormal_hepatobiliary_system0.60543946
84MP0008874_decreased_physiological_sensi0.60037844
85MP0000313_abnormal_cell_death0.59690867
86MP0001533_abnormal_skeleton_physiology0.57976175
87MP0006082_CNS_inflammation0.57271710
88MP0004957_abnormal_blastocyst_morpholog0.56907030
89MP0000249_abnormal_blood_vessel0.56779493
90MP0002083_premature_death0.56048078
91MP0001730_embryonic_growth_arrest0.55113400
92MP0005174_abnormal_tail_pigmentation0.54427076
93MP0002075_abnormal_coat/hair_pigmentati0.53777793
94MP0003191_abnormal_cellular_cholesterol0.53262283
95MP0009763_increased_sensitivity_to0.52884651
96MP0002877_abnormal_melanocyte_morpholog0.52811987
97MP0003279_aneurysm0.52773396
98MP0003453_abnormal_keratinocyte_physiol0.52751648
99MP0009931_abnormal_skin_appearance0.52643773
100MP0000767_abnormal_smooth_muscle0.52190249
101MP0002132_abnormal_respiratory_system0.52156297
102MP0003566_abnormal_cell_adhesion0.51913106
103MP0000013_abnormal_adipose_tissue0.51507959
104MP0000609_abnormal_liver_physiology0.50872479
105MP0005408_hypopigmentation0.50718572
106MP0002009_preneoplasia0.50662636
107MP0003252_abnormal_bile_duct0.50627854
108MP0005166_decreased_susceptibility_to0.50478761
109MP0010307_abnormal_tumor_latency0.50305704
110MP0002693_abnormal_pancreas_physiology0.49072592
111MP0003221_abnormal_cardiomyocyte_apopto0.47762212
112MP0005584_abnormal_enzyme/coenzyme_acti0.46684198
113MP0001919_abnormal_reproductive_system0.45742171
114MP0005384_cellular_phenotype0.45682420
115MP0003786_premature_aging0.44798296
116MP0005451_abnormal_body_composition0.44730210
117MP0000477_abnormal_intestine_morphology0.44426337
118MP0005220_abnormal_exocrine_pancreas0.44006455
119MP0003656_abnormal_erythrocyte_physiolo0.43921935
120MP0000015_abnormal_ear_pigmentation0.43631344
121MP0001784_abnormal_fluid_regulation0.43369335
122MP0001186_pigmentation_phenotype0.42752569
123MP0001915_intracranial_hemorrhage0.42103506
124MP0000733_abnormal_muscle_development0.41765816
125MP0000003_abnormal_adipose_tissue0.41110016
126MP0005379_endocrine/exocrine_gland_phen0.41056813

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.84668619
2Cellulitis (HP:0100658)7.07170391
3Papilloma (HP:0012740)7.02470486
4Verrucae (HP:0200043)7.02470486
5Recurrent bronchitis (HP:0002837)6.58013047
6Gastrointestinal stroma tumor (HP:0100723)6.50170084
7Recurrent sinusitis (HP:0011108)5.92709115
8Colitis (HP:0002583)5.91685394
9Abnormality of B cell number (HP:0010975)5.90719618
10B lymphocytopenia (HP:0010976)5.90719618
11Recurrent viral infections (HP:0004429)5.16880696
12Small epiphyses (HP:0010585)5.09757434
13Meningitis (HP:0001287)5.02227991
14Inflammation of the large intestine (HP:0002037)4.94559802
15Chronic sinusitis (HP:0011109)4.94535023
16Gastrointestinal inflammation (HP:0004386)4.79700415
17Panhypogammaglobulinemia (HP:0003139)4.74442179
18Thyroiditis (HP:0100646)4.69797445
19IgM deficiency (HP:0002850)4.56920121
20Osteomyelitis (HP:0002754)4.29434948
21Lymphopenia (HP:0001888)4.17571758
22Emphysema (HP:0002097)4.14102417
23Recurrent pneumonia (HP:0006532)4.06707636
24Abnormality of cells of the lymphoid lineage (HP:0012140)4.00081406
25Sepsis (HP:0100806)3.86481526
26Recurrent otitis media (HP:0000403)3.86152733
27Bronchitis (HP:0012387)3.80395950
28Recurrent lower respiratory tract infections (HP:0002783)3.78216162
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.63150867
30Mitral stenosis (HP:0001718)3.59299186
31Chronic otitis media (HP:0000389)3.52212493
32Vasculitis (HP:0002633)3.46146173
33Vertebral arch anomaly (HP:0008438)3.45410679
34IgG deficiency (HP:0004315)3.37753859
35Recurrent fungal infections (HP:0002841)3.35407811
36Restrictive lung disease (HP:0002091)3.34106386
37Flattened epiphyses (HP:0003071)3.22817747
38Hypoplasia of the capital femoral epiphysis (HP:0003090)3.21438668
39IgA deficiency (HP:0002720)3.14350555
40T lymphocytopenia (HP:0005403)2.98379031
41Abnormality of the prostate (HP:0008775)2.94874230
42Abnormality of T cell number (HP:0011839)2.89188873
43Abnormality of macrophages (HP:0004311)2.87493596
44Abnormality of the intervertebral disk (HP:0005108)2.86886082
45Skin rash (HP:0000988)2.86501943
46Combined immunodeficiency (HP:0005387)2.81650116
47Arthropathy (HP:0003040)2.81386930
48Recurrent abscess formation (HP:0002722)2.78398913
49Abnormality of the fingertips (HP:0001211)2.72137616
50Severe combined immunodeficiency (HP:0004430)2.69998523
51Recurrent bacterial skin infections (HP:0005406)2.69522056
52Urticaria (HP:0001025)2.62663025
53Irregular vertebral endplates (HP:0003301)2.61294872
54Abnormality of T cells (HP:0002843)2.60763728
55Lymphoma (HP:0002665)2.58426187
56Ulnar bowing (HP:0003031)2.58160898
57Absent epiphyses (HP:0010577)2.54020424
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54020424
59Chronic mucocutaneous candidiasis (HP:0002728)2.51233330
60Recurrent cutaneous fungal infections (HP:0011370)2.51233330
61Mediastinal lymphadenopathy (HP:0100721)2.48737299
62Hypoplasia of the thymus (HP:0000778)2.44652813
63Leukopenia (HP:0001882)2.39596459
64Viral hepatitis (HP:0006562)2.30369843
65Obstructive lung disease (HP:0006536)2.27641063
66Chronic obstructive pulmonary disease (HP:0006510)2.27641063
67Chest pain (HP:0100749)2.26200121
68Neutropenia (HP:0001875)2.24830939
69Abnormality of T cell physiology (HP:0011840)2.24540589
70Eosinophilia (HP:0001880)2.22079811
71Recurrent skin infections (HP:0001581)2.21995865
72Skin ulcer (HP:0200042)2.20315757
73Interstitial pulmonary disease (HP:0006530)2.12943757
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11928491
75Gastrointestinal infarctions (HP:0005244)2.11071696
76Nasal polyposis (HP:0100582)2.09515188
77Increased IgM level (HP:0003496)2.08796925
78Eczematoid dermatitis (HP:0000976)2.03883768
79Abnormality of the peritoneum (HP:0002585)2.01736515
80Abnormality of the pleura (HP:0002103)2.00163656
81Hepatitis (HP:0012115)1.99380959
82Hypertensive crisis (HP:0100735)1.95869486
83Autoimmune thrombocytopenia (HP:0001973)1.95767271
84Abnormality of the vertebral endplates (HP:0005106)1.93149568
85Abnormality of male internal genitalia (HP:0000022)1.92821013
86Barrel-shaped chest (HP:0001552)1.92627143
87Increased IgE level (HP:0003212)1.92626721
88Limited elbow extension (HP:0001377)1.90126123
89Thrombocytosis (HP:0001894)1.89439073
90Squamous cell carcinoma (HP:0002860)1.89367565
91Progressive external ophthalmoplegia (HP:0000590)1.87099647
92Pustule (HP:0200039)1.86952812
93Granulocytopenia (HP:0001913)1.86458846
94Encephalitis (HP:0002383)1.82512079
95Abnormality of eosinophils (HP:0001879)1.82507221
96Dehydration (HP:0001944)1.82079717
97Spontaneous hematomas (HP:0007420)1.81742795
98Fatigue (HP:0012378)1.81313389
99Basal cell carcinoma (HP:0002671)1.81251865
100Autoimmune hemolytic anemia (HP:0001890)1.80610903
101Hematochezia (HP:0002573)1.78706683
102Premature loss of primary teeth (HP:0006323)1.76342982
103Vertebral clefting (HP:0008428)1.75232345
104Poikiloderma (HP:0001029)1.74254187
105Gingivitis (HP:0000230)1.73974104
106Pulmonary fibrosis (HP:0002206)1.73649927
107Optic neuritis (HP:0100653)1.71312787
108Retrobulbar optic neuritis (HP:0100654)1.71312787
109Villous atrophy (HP:0011473)1.68778859
110Abnormality of small intestinal villus morphology (HP:0011472)1.68778859
111Hypergammaglobulinemia (HP:0010702)1.66404275
112Abnormality of the nasal mucosa (HP:0000433)1.66373695
113Aplasia/Hypoplasia of the thymus (HP:0010515)1.65403822
114Deep palmar crease (HP:0006191)1.65186560
115Chronic diarrhea (HP:0002028)1.63781170
116Aortic regurgitation (HP:0001659)1.61926684
117Teleangiectasia of the skin (HP:0100585)1.61609547
118Arthralgia (HP:0002829)1.61130941
119Pulmonary infiltrates (HP:0002113)1.59035733
120Facial diplegia (HP:0001349)1.58072462
121Aqueductal stenosis (HP:0002410)1.56502983
122External ear malformation (HP:0008572)1.56013428
123Albinism (HP:0001022)1.55590324
124Amaurosis fugax (HP:0100576)1.54573691
125Elevated hepatic transaminases (HP:0002910)1.53892137
126Abnormality of the thymus (HP:0000777)1.53665461
127Acrocyanosis (HP:0001063)1.52124876
128Long eyelashes (HP:0000527)1.48482355
129Recurrent gram-negative bacterial infections (HP:0005420)1.47368228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.88911672
2MAP4K15.72875357
3GRK64.50743981
4ERN13.46952238
5BLK3.13612464
6PRPF4B2.96924583
7SYK2.67487492
8CSF1R2.63677405
9RIPK42.45343511
10BTK2.15940776
11TLK12.15104346
12SMG12.02524544
13STK102.00757597
14LRRK21.89236028
15NEK91.67579376
16LYN1.66459630
17SIK21.63906731
18EEF2K1.60830468
19STK41.53546387
20TYK21.46982834
21MAP3K141.45777051
22CDK121.42400722
23EIF2AK31.39452238
24CDK191.36901392
25PIM11.34173034
26MAP3K131.32855906
27MAP3K91.30960025
28CSK1.30661579
29TRIB31.28013114
30TBK11.25101723
31BMPR21.24434446
32JAK11.22851308
33HCK1.22725693
34CDK91.15812294
35CLK11.15107330
36CDK41.12486630
37MST41.10277418
38FES1.10245957
39NEK21.09685442
40PASK1.08649411
41MARK31.03159421
42VRK11.01281483
43DYRK1B0.98594368
44FRK0.98060558
45ARAF0.94613648
46IKBKB0.94409550
47MAPK70.92007391
48FGFR30.91082548
49LCK0.90868296
50MATK0.90677029
51PRKCQ0.87869036
52TNK20.86027884
53ITK0.85298488
54NME20.83583436
55KIT0.81495750
56HIPK20.78679263
57ZAP700.78588057
58GRK10.77931408
59IRAK40.72482231
60PRKD20.69418101
61MELK0.68378567
62MAP3K80.67910536
63TEC0.67371821
64SIK30.67363260
65PKN20.66573769
66KSR20.66298973
67WNK10.66002383
68PRKCH0.65488842
69PRKD10.65277758
70BRD40.64821979
71SIK10.64216183
72DYRK30.63538159
73MAP2K30.63436241
74MAP2K10.63330737
75JAK30.60311235
76IKBKE0.59593993
77ICK0.59157745
78TGFBR20.58752889
79MAPK40.58569323
80BRAF0.56122324
81RPS6KB20.53248021
82RPS6KA40.52151223
83MAPK120.51726634
84FYN0.50501188
85TAF10.50337609
86MAP3K70.50209408
87JAK20.50008134
88FGFR20.49329946
89RAF10.48334258
90PIK3CG0.47877729
91PKN10.47641322
92SCYL20.47383611
93INSR0.45608027
94ALK0.45521878
95PDK10.45214265
96RPS6KA50.43232345
97IRAK30.42712986
98TESK20.42263114
99ZAK0.41906075
100TAOK20.41832856
101CSNK1D0.41164063
102CHUK0.40438760
103PDPK10.39500016
104MAPK110.39114008
105CDC42BPA0.38581078
106ABL10.37161358
107MAPKAPK20.37059456
108DAPK30.36434048
109MAP3K110.36386770
110SGK30.35917336
111NLK0.35494146
112MAP3K10.35325998
113FGFR40.35267980
114IRAK20.34249565
115CHEK10.33431773
116ATR0.33348252
117STK110.33026656
118PRKCD0.32940128
119FGR0.31675588
120EGFR0.28030334
121PRKCI0.28026560
122CDK60.27609832
123CDC70.27364407
124CCNB10.27283794
125STK240.27162955
126TAOK30.25312724
127AURKB0.22311028

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.31053644
2B cell receptor signaling pathway_Homo sapiens_hsa046626.25198842
3Autoimmune thyroid disease_Homo sapiens_hsa053204.04532734
4Graft-versus-host disease_Homo sapiens_hsa053323.82313274
5Type I diabetes mellitus_Homo sapiens_hsa049403.27368982
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.18054707
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.80852906
8Systemic lupus erythematosus_Homo sapiens_hsa053222.72287743
9Non-homologous end-joining_Homo sapiens_hsa034502.52700921
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.42112701
11Hematopoietic cell lineage_Homo sapiens_hsa046402.41636509
12Staphylococcus aureus infection_Homo sapiens_hsa051502.25054248
13Osteoclast differentiation_Homo sapiens_hsa043802.10129672
14Base excision repair_Homo sapiens_hsa034102.09860209
15Antigen processing and presentation_Homo sapiens_hsa046122.02845821
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.01365824
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88170183
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69433828
19Leishmaniasis_Homo sapiens_hsa051401.63896371
20Mismatch repair_Homo sapiens_hsa034301.60481239
21Viral carcinogenesis_Homo sapiens_hsa052031.56302919
22Alcoholism_Homo sapiens_hsa050341.54400886
23T cell receptor signaling pathway_Homo sapiens_hsa046601.51973964
24Non-small cell lung cancer_Homo sapiens_hsa052231.46291656
25DNA replication_Homo sapiens_hsa030301.43214675
26Chemokine signaling pathway_Homo sapiens_hsa040621.37426840
27Epstein-Barr virus infection_Homo sapiens_hsa051691.36311205
28Herpes simplex infection_Homo sapiens_hsa051681.30474688
29Measles_Homo sapiens_hsa051621.28548461
30Tuberculosis_Homo sapiens_hsa051521.25846155
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23078200
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16855391
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.15306186
34Chronic myeloid leukemia_Homo sapiens_hsa052201.13835733
35Rheumatoid arthritis_Homo sapiens_hsa053231.13280717
36Hepatitis B_Homo sapiens_hsa051611.08705329
37Platelet activation_Homo sapiens_hsa046111.07473337
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03277073
39Pancreatic cancer_Homo sapiens_hsa052121.01224441
40Shigellosis_Homo sapiens_hsa051310.96491140
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93183416
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.92412216
43Apoptosis_Homo sapiens_hsa042100.91738668
44Ribosome_Homo sapiens_hsa030100.90718286
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88987349
46Influenza A_Homo sapiens_hsa051640.87677170
47Toxoplasmosis_Homo sapiens_hsa051450.87571220
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.86258959
49HTLV-I infection_Homo sapiens_hsa051660.84279413
50Acute myeloid leukemia_Homo sapiens_hsa052210.82667264
51Phagosome_Homo sapiens_hsa041450.79743764
52Small cell lung cancer_Homo sapiens_hsa052220.73634942
53Glioma_Homo sapiens_hsa052140.72315267
54MicroRNAs in cancer_Homo sapiens_hsa052060.70517514
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70180330
56FoxO signaling pathway_Homo sapiens_hsa040680.68723428
57Homologous recombination_Homo sapiens_hsa034400.64740094
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64538867
59African trypanosomiasis_Homo sapiens_hsa051430.64334026
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63531973
61VEGF signaling pathway_Homo sapiens_hsa043700.62386042
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61133634
63Viral myocarditis_Homo sapiens_hsa054160.58222646
64Spliceosome_Homo sapiens_hsa030400.57334332
65Inositol phosphate metabolism_Homo sapiens_hsa005620.57326112
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57101277
67mTOR signaling pathway_Homo sapiens_hsa041500.56230938
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55085760
69Asthma_Homo sapiens_hsa053100.53799601
70Insulin resistance_Homo sapiens_hsa049310.53315015
71Hepatitis C_Homo sapiens_hsa051600.52905444
72TNF signaling pathway_Homo sapiens_hsa046680.52256238
73Prostate cancer_Homo sapiens_hsa052150.52044125
74Malaria_Homo sapiens_hsa051440.52017765
75Lysine degradation_Homo sapiens_hsa003100.49414131
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49213896
77MAPK signaling pathway_Homo sapiens_hsa040100.48990943
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.48750247
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48528037
80Cell cycle_Homo sapiens_hsa041100.48387865
81Nucleotide excision repair_Homo sapiens_hsa034200.47484102
82p53 signaling pathway_Homo sapiens_hsa041150.44890339
83Colorectal cancer_Homo sapiens_hsa052100.44818684
84Pertussis_Homo sapiens_hsa051330.43302607
85mRNA surveillance pathway_Homo sapiens_hsa030150.41896330
86Endocytosis_Homo sapiens_hsa041440.41668760
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40462456
88Salmonella infection_Homo sapiens_hsa051320.38393813
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37628499
90Other glycan degradation_Homo sapiens_hsa005110.35839238
91N-Glycan biosynthesis_Homo sapiens_hsa005100.35480447
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34983050
93Legionellosis_Homo sapiens_hsa051340.34851694
94Choline metabolism in cancer_Homo sapiens_hsa052310.30677744
95Fanconi anemia pathway_Homo sapiens_hsa034600.30194075
96Pentose phosphate pathway_Homo sapiens_hsa000300.29886549
97Allograft rejection_Homo sapiens_hsa053300.29575931
98Renal cell carcinoma_Homo sapiens_hsa052110.29069400
99Proteoglycans in cancer_Homo sapiens_hsa052050.28864891
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27754042
101One carbon pool by folate_Homo sapiens_hsa006700.26535165
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25943505
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22741054
104Notch signaling pathway_Homo sapiens_hsa043300.22635447
105Endometrial cancer_Homo sapiens_hsa052130.22235888
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21847820
107HIF-1 signaling pathway_Homo sapiens_hsa040660.21712807
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.20748199
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20724091
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19484914
111Prolactin signaling pathway_Homo sapiens_hsa049170.19176931
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19105962
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.18833473
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15284876
115Bladder cancer_Homo sapiens_hsa052190.13576402
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13250314
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11409633

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