FDCSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)8.40223912
2regulation of dendritic cell antigen processing and presentation (GO:0002604)7.74829186
3germinal center formation (GO:0002467)7.59630692
4positive regulation of pseudopodium assembly (GO:0031274)7.57636835
5regulation of pseudopodium assembly (GO:0031272)6.84436182
6endothelial cell chemotaxis (GO:0035767)6.36192836
7regulation of integrin activation (GO:0033623)5.92102956
8regulation of endothelial cell chemotaxis (GO:2001026)5.75884823
9positive regulation of antigen processing and presentation (GO:0002579)5.63502295
10positive regulation of cell adhesion mediated by integrin (GO:0033630)5.34757522
11positive regulation of glycoprotein biosynthetic process (GO:0010560)5.18993756
12positive regulation of glycoprotein metabolic process (GO:1903020)5.02919108
13desmosome organization (GO:0002934)4.94263230
14regulation of cellular extravasation (GO:0002691)4.93507714
15regulation of T-helper 1 cell differentiation (GO:0045625)4.83968319
16regulation of antigen processing and presentation (GO:0002577)4.73296064
17complement activation, classical pathway (GO:0006958)4.25891845
18dendritic cell chemotaxis (GO:0002407)4.18653974
19response to prostaglandin E (GO:0034695)4.00686819
20positive regulation of Cdc42 GTPase activity (GO:0043089)3.98659336
21positive regulation of neutrophil chemotaxis (GO:0090023)3.97138033
22positive regulation of neutrophil migration (GO:1902624)3.97138033
23positive regulation of granulocyte chemotaxis (GO:0071624)3.88540778
24lymphocyte chemotaxis (GO:0048247)3.87034715
25NIK/NF-kappaB signaling (GO:0038061)3.83870800
26lymph node development (GO:0048535)3.82075408
27positive regulation of Rap GTPase activity (GO:0032854)3.74960507
28positive regulation of T cell migration (GO:2000406)3.72373210
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.72020075
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70357750
31antigen processing and presentation of endogenous antigen (GO:0019883)3.63306511
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60555483
33chronic inflammatory response (GO:0002544)3.58284408
34regulation of T cell migration (GO:2000404)3.51519627
35positive regulation of T cell chemotaxis (GO:0010820)3.50095916
36regulation of T cell chemotaxis (GO:0010819)3.50095916
37keratinocyte proliferation (GO:0043616)3.34715471
38vascular endothelial growth factor signaling pathway (GO:0038084)3.27219195
39complement activation (GO:0006956)3.24536399
40dendritic cell migration (GO:0036336)3.20981001
41positive regulation of lymphocyte migration (GO:2000403)3.12551945
42vitamin A metabolic process (GO:0006776)3.08411180
43regulation of glycoprotein biosynthetic process (GO:0010559)3.08101376
44regulation of Rap GTPase activity (GO:0032317)3.03222695
45ventricular cardiac muscle cell action potential (GO:0086005)3.02234496
46glomerular filtration (GO:0003094)3.01859537
47regulation of macrophage chemotaxis (GO:0010758)3.00654248
48response to nitric oxide (GO:0071731)3.00087883
49response to prostaglandin (GO:0034694)2.98712954
50positive regulation of respiratory burst (GO:0060267)2.93906030
51antimicrobial humoral response (GO:0019730)2.93038047
52angiotensin maturation (GO:0002003)2.92976851
53regulation of lymphocyte migration (GO:2000401)2.91155366
54interferon-gamma-mediated signaling pathway (GO:0060333)2.89437154
55regulation of glycoprotein metabolic process (GO:1903018)2.85561713
56negative regulation of glycoprotein biosynthetic process (GO:0010561)2.84131952
57adhesion of symbiont to host cell (GO:0044650)2.82783062
58virion attachment to host cell (GO:0019062)2.82783062
59retina homeostasis (GO:0001895)2.81706877
60mammary gland epithelial cell differentiation (GO:0060644)2.81267647
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77794682
62lung lobe morphogenesis (GO:0060463)2.76540098
63cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73131865
64regulation of neutrophil chemotaxis (GO:0090022)2.72398903
65regulation of neutrophil migration (GO:1902622)2.72398903
66T cell costimulation (GO:0031295)2.72063955
67renal filtration (GO:0097205)2.71734476
68glucocorticoid receptor signaling pathway (GO:0042921)2.69889802
69cytoplasmic mRNA processing body assembly (GO:0033962)2.69690075
70positive regulation of lipid kinase activity (GO:0090218)2.69323836
71antibacterial humoral response (GO:0019731)2.68095480
72lymphocyte costimulation (GO:0031294)2.67593646
73regulation of necroptotic process (GO:0060544)2.65697059
74positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.65299960
75regulation of Cdc42 GTPase activity (GO:0043088)2.63589132
76activation of Ras GTPase activity (GO:0032856)2.61600292
77histone H3-K4 trimethylation (GO:0080182)2.58828641
78regulation of MHC class I biosynthetic process (GO:0045343)2.58707041
79negative regulation of leukocyte migration (GO:0002686)2.57147132
80response to type I interferon (GO:0034340)2.56354203
81regulation of transforming growth factor beta1 production (GO:0032908)2.56351849
82ruffle organization (GO:0031529)2.55872382
83regulation of histone deacetylation (GO:0031063)2.55430379
84regulation of lymphocyte chemotaxis (GO:1901623)2.52936227
85regulation of granulocyte chemotaxis (GO:0071622)2.51386790
86cell communication involved in cardiac conduction (GO:0086065)2.49056675
87adhesion of symbiont to host (GO:0044406)2.48558658
88T-helper 1 type immune response (GO:0042088)2.48194526
89regulation of heart rate by cardiac conduction (GO:0086091)2.46984143
90cellular response to virus (GO:0098586)2.46086747
91regulation of respiratory burst (GO:0060263)2.45910660
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45729486
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.44234271
94immunoglobulin mediated immune response (GO:0016064)2.42423199
95cellular response to exogenous dsRNA (GO:0071360)2.39673074
96regulation of guanylate cyclase activity (GO:0031282)2.39403589
97cellular response to type I interferon (GO:0071357)2.37292417
98type I interferon signaling pathway (GO:0060337)2.37292417
99positive regulation of leukocyte chemotaxis (GO:0002690)2.35759800
100substrate-dependent cell migration (GO:0006929)2.35447800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.35867635
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91538938
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82527844
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.82110976
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81733711
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.49147187
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40700120
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38203059
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33062970
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.22057564
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.12659615
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.07702010
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03853716
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99137420
15GATA1_22025678_ChIP-Seq_K562_Human1.90019835
16MYC_22102868_ChIP-Seq_BL_Human1.87007405
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79422732
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.75804293
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.72852622
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72003766
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69052447
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67727109
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66237297
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64796380
25NFIB_24661679_ChIP-Seq_LUNG_Mouse1.64019480
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.63447832
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.62023634
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61446802
29TCF7_22412390_ChIP-Seq_EML_Mouse1.61270506
30RUNX_20019798_ChIP-Seq_JUKART_Human1.60136991
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59330181
32RACK7_27058665_Chip-Seq_MCF-7_Human1.57317590
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55369380
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54181332
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.53135049
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51751474
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51222130
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.47364381
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46770993
40CLOCK_20551151_ChIP-Seq_293T_Human1.46709566
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45665037
42GATA6_25053715_ChIP-Seq_YYC3_Human1.45067332
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44238182
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.42595306
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41278426
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39822796
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38517144
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38070175
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36805816
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36384807
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.34477961
52SOX2_20726797_ChIP-Seq_SW620_Human1.33933863
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33808381
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33342042
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32098367
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.30934184
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29697465
58VDR_24763502_ChIP-Seq_THP-1_Human1.26630457
59SCL_19346495_ChIP-Seq_HPC-7_Human1.25835650
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.24722159
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22435537
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21558289
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20781079
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20781079
65LXR_22292898_ChIP-Seq_THP-1_Human1.20432799
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16996663
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16268416
68KDM2B_26808549_Chip-Seq_DND41_Human1.15575434
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.15481379
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15029189
71MAF_26560356_Chip-Seq_TH1_Human1.14073983
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.13420691
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.13420691
74AHR_22903824_ChIP-Seq_MCF-7_Human1.12634405
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11751797
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10881889
77GATA4_25053715_ChIP-Seq_YYC3_Human1.10346077
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09009129
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.06471948
80MYB_26560356_Chip-Seq_TH2_Human1.06339990
81VDR_21846776_ChIP-Seq_THP-1_Human1.05669083
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03622020
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.03336929
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01665923
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.01031538
86SPI1_23127762_ChIP-Seq_K562_Human1.01022064
87MYB_26560356_Chip-Seq_TH1_Human1.00007611
88STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99867099
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97298004
90KLF5_25053715_ChIP-Seq_YYC3_Human0.96670895
91GATA1_19941826_ChIP-Seq_K562_Human0.94283828
92CJUN_26792858_Chip-Seq_BT549_Human0.92064049
93GATA2_19941826_ChIP-Seq_K562_Human0.91216759
94KDM2B_26808549_Chip-Seq_K562_Human0.90973485
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90880248
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.90364168
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89432661
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89421392
99UTX_26944678_Chip-Seq_JUKART_Human0.89043158
100RXR_22108803_ChIP-Seq_LS180_Human0.88108680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.79423537
2MP0010352_gastrointestinal_tract_polyps4.56888904
3MP0000685_abnormal_immune_system3.48984013
4MP0001790_abnormal_immune_system2.78395372
5MP0005387_immune_system_phenotype2.78395372
6MP0003941_abnormal_skin_development2.70722388
7MP0004264_abnormal_extraembryonic_tissu2.69120522
8MP0003091_abnormal_cell_migration2.48575381
9MP0010155_abnormal_intestine_physiology2.46557407
10MP0003453_abnormal_keratinocyte_physiol2.41417069
11MP0001835_abnormal_antigen_presentation2.38632864
12MP0001873_stomach_inflammation2.36090326
13MP0003300_gastrointestinal_ulcer2.21238736
14MP0001800_abnormal_humoral_immune2.13505500
15MP0005023_abnormal_wound_healing2.12002757
16MP0003763_abnormal_thymus_physiology2.01596820
17MP0003866_abnormal_defecation1.95841361
18MP0003566_abnormal_cell_adhesion1.88642974
19MP0005310_abnormal_salivary_gland1.79412746
20MP0002098_abnormal_vibrissa_morphology1.76484378
21MP0003705_abnormal_hypodermis_morpholog1.73097058
22MP0003279_aneurysm1.68319420
23MP0005360_urolithiasis1.67071876
24MP0004510_myositis1.65501115
25MP0003436_decreased_susceptibility_to1.64533480
26MP0001666_abnormal_nutrient_absorption1.63104773
27MP0003045_fibrosis1.60235993
28MP0002452_abnormal_antigen_presenting1.56159880
29MP0003868_abnormal_feces_composition1.55846103
30MP0005000_abnormal_immune_tolerance1.54246601
31MP0005025_abnormal_response_to1.53611461
32MP0003183_abnormal_peptide_metabolism1.53200599
33MP0005671_abnormal_response_to1.52887825
34MP0009840_abnormal_foam_cell1.51341396
35MP0009278_abnormal_bone_marrow1.48926154
36MP0005166_decreased_susceptibility_to1.47977227
37MP0001879_abnormal_lymphatic_vessel1.47060889
38MP0000569_abnormal_digit_pigmentation1.44845183
39MP0002166_altered_tumor_susceptibility1.44828262
40MP0003724_increased_susceptibility_to1.43548183
41MP0002396_abnormal_hematopoietic_system1.40184750
42MP0003303_peritoneal_inflammation1.38214717
43MP0004947_skin_inflammation1.32504074
44MP0000377_abnormal_hair_follicle1.32468997
45MP0000762_abnormal_tongue_morphology1.31971879
46MP0002420_abnormal_adaptive_immunity1.31849452
47MP0005076_abnormal_cell_differentiation1.28789397
48MP0002138_abnormal_hepatobiliary_system1.28484381
49MP0005409_darkened_coat_color1.28135946
50MP0001216_abnormal_epidermal_layer1.27478304
51MP0002723_abnormal_immune_serum1.26018222
52MP0001819_abnormal_immune_cell1.25945529
53MP0004808_abnormal_hematopoietic_stem1.22164271
54MP0002933_joint_inflammation1.22043930
55MP0001881_abnormal_mammary_gland1.21022136
56MP0002148_abnormal_hypersensitivity_rea1.18131574
57MP0002876_abnormal_thyroid_physiology1.14697614
58MP0000716_abnormal_immune_system1.13679091
59MP0008004_abnormal_stomach_pH1.12379650
60MP0001502_abnormal_circadian_rhythm1.11662785
61MP0002060_abnormal_skin_morphology1.09761501
62MP0004858_abnormal_nervous_system1.09361668
63MP0010234_abnormal_vibrissa_follicle1.09325989
64MP0005365_abnormal_bile_salt1.09263370
65MP0000627_abnormal_mammary_gland1.09212699
66MP0002009_preneoplasia1.08626947
67MP0005670_abnormal_white_adipose1.08147085
68MP0002796_impaired_skin_barrier1.06888746
69MP0005666_abnormal_adipose_tissue1.06504850
70MP0009785_altered_susceptibility_to1.06494618
71MP0009115_abnormal_fat_cell1.05371705
72MP0002254_reproductive_system_inflammat1.03892818
73MP0002419_abnormal_innate_immunity1.03270887
74MP0005375_adipose_tissue_phenotype1.03137805
75MP0002398_abnormal_bone_marrow1.01461807
76MP0000467_abnormal_esophagus_morphology0.96956354
77MP0002405_respiratory_system_inflammati0.93693264
78MP0001845_abnormal_inflammatory_respons0.92893217
79MP0001853_heart_inflammation0.91331697
80MP0006138_congestive_heart_failure0.90022315
81MP0001663_abnormal_digestive_system0.87944791
82MP0005397_hematopoietic_system_phenotyp0.87153503
83MP0001545_abnormal_hematopoietic_system0.87153503
84MP0002998_abnormal_bone_remodeling0.86372984
85MP0000249_abnormal_blood_vessel0.83321116
86MP0000477_abnormal_intestine_morphology0.82678745
87MP0001851_eye_inflammation0.81311695
88MP0000003_abnormal_adipose_tissue0.80440842
89MP0002249_abnormal_larynx_morphology0.80298042
90MP0005621_abnormal_cell_physiology0.79986306
91MP0001533_abnormal_skeleton_physiology0.79784531
92MP0005451_abnormal_body_composition0.78185952
93MP0004185_abnormal_adipocyte_glucose0.78141909
94MP0001346_abnormal_lacrimal_gland0.78140423
95MP0005275_abnormal_skin_tensile0.77075442
96MP0002429_abnormal_blood_cell0.76002436
97MP0002136_abnormal_kidney_physiology0.75814406
98MP0009643_abnormal_urine_homeostasis0.73463072
99MP0000465_gastrointestinal_hemorrhage0.72835469
100MP0005164_abnormal_response_to0.72406692

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)9.52590486
2Lip pit (HP:0100267)6.32437004
3Gastrointestinal stroma tumor (HP:0100723)5.19352963
4Malnutrition (HP:0004395)4.48105580
5Obstructive sleep apnea (HP:0002870)4.11604716
6Popliteal pterygium (HP:0009756)4.09640396
7Chronic diarrhea (HP:0002028)4.01478496
8Sparse lateral eyebrow (HP:0005338)3.77247241
9Emphysema (HP:0002097)3.65400368
10Agammaglobulinemia (HP:0004432)3.56715766
11Recurrent bronchitis (HP:0002837)3.53347937
12Systemic lupus erythematosus (HP:0002725)3.31201319
13Abnormality of the fingertips (HP:0001211)3.31187925
14Colitis (HP:0002583)3.12793754
15Ventricular tachycardia (HP:0004756)3.06377951
16Spondylolisthesis (HP:0003302)3.02221848
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.01636614
18Polygenic inheritance (HP:0010982)2.99162081
19Eczematoid dermatitis (HP:0000976)2.92592799
20Hypoplastic labia majora (HP:0000059)2.89579620
21Broad face (HP:0000283)2.85904604
22Villous atrophy (HP:0011473)2.85187323
23Abnormality of small intestinal villus morphology (HP:0011472)2.85187323
24Vasculitis (HP:0002633)2.74834570
25Woolly hair (HP:0002224)2.74668311
26Restrictive lung disease (HP:0002091)2.73366921
27Abnormality of the salivary glands (HP:0010286)2.70764867
28IgA deficiency (HP:0002720)2.65311748
29Abnormality of the labia majora (HP:0012881)2.63593355
30Panhypogammaglobulinemia (HP:0003139)2.62379668
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.60520695
32Long eyelashes (HP:0000527)2.58742147
33Asymmetric septal hypertrophy (HP:0001670)2.57679085
34Hypoplasia of the uterus (HP:0000013)2.44945720
35Hyperparathyroidism (HP:0000843)2.44690151
36Genetic anticipation (HP:0003743)2.40976204
37Macroorchidism (HP:0000053)2.37669404
38Cellulitis (HP:0100658)2.36767912
39Palpitations (HP:0001962)2.33621830
40Abnormality of complement system (HP:0005339)2.30824334
41Lymphopenia (HP:0001888)2.30165601
42Inflammation of the large intestine (HP:0002037)2.28165555
43Advanced eruption of teeth (HP:0006288)2.26175560
44Gastrointestinal inflammation (HP:0004386)2.25762466
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.25746435
46Urethral obstruction (HP:0000796)2.24231822
47Increased IgE level (HP:0003212)2.23049841
48Loss of speech (HP:0002371)2.22565214
49Abnormality of nail color (HP:0100643)2.21793661
50Acute myeloid leukemia (HP:0004808)2.19635531
51Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.19327059
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18061040
53Deep philtrum (HP:0002002)2.17657524
54Ventricular arrhythmia (HP:0004308)2.15449040
55Distal lower limb amyotrophy (HP:0008944)2.14915087
56Natal tooth (HP:0000695)2.13227888
57Complement deficiency (HP:0004431)2.09317025
58Shallow orbits (HP:0000586)2.05165787
59Osteolytic defects of the hand bones (HP:0009699)2.02661665
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.02661665
61Dislocated radial head (HP:0003083)2.02426057
62Urinary glycosaminoglycan excretion (HP:0003541)2.01298585
63Mucopolysacchariduria (HP:0008155)2.01298585
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.00953670
65Nephritis (HP:0000123)1.99976893
66Narrow palate (HP:0000189)1.99505216
67Bronchitis (HP:0012387)1.96336804
68Dysostosis multiplex (HP:0000943)1.95570936
69Meningitis (HP:0001287)1.94500344
70Chronic otitis media (HP:0000389)1.90933471
71Spontaneous hematomas (HP:0007420)1.89716648
72Segmental peripheral demyelination/remyelination (HP:0003481)1.89338235
73Glomerulonephritis (HP:0000099)1.88268981
74Flat capital femoral epiphysis (HP:0003370)1.85832218
75Germ cell neoplasia (HP:0100728)1.85713982
76Disproportionate tall stature (HP:0001519)1.83597470
77Abnormality of the radial head (HP:0003995)1.83497208
78Synophrys (HP:0000664)1.80976559
79Abnormality of the epiphyses of the hand (HP:0005924)1.77499861
80Skin pits (HP:0100276)1.77046657
81Chronic sinusitis (HP:0011109)1.77002141
82Recurrent cutaneous fungal infections (HP:0011370)1.76548958
83Chronic mucocutaneous candidiasis (HP:0002728)1.76548958
84Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76334256
85Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76334256
86Abnormality of polysaccharide metabolism (HP:0011012)1.76334256
87Autoimmune thrombocytopenia (HP:0001973)1.73686694
88Recurrent sinusitis (HP:0011108)1.73613125
89Premature skin wrinkling (HP:0100678)1.73011950
90Centrally nucleated skeletal muscle fibers (HP:0003687)1.71435587
91Alacrima (HP:0000522)1.71369513
92Thin bony cortex (HP:0002753)1.70670358
93Ureteral stenosis (HP:0000071)1.69694078
94Autoimmune hemolytic anemia (HP:0001890)1.67504887
95Verrucae (HP:0200043)1.66417799
96Papilloma (HP:0012740)1.66417799
97Recurrent fungal infections (HP:0002841)1.65104866
98Bronchomalacia (HP:0002780)1.64997664
99Abnormality of the gastric mucosa (HP:0004295)1.64828299
100Coarse hair (HP:0002208)1.64630602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.22259603
2TRIB33.37851218
3EPHA33.25764910
4CDC42BPA2.94636114
5CDK122.88527807
6MAP4K12.63733023
7SIK32.56793122
8FGFR42.47306107
9RIPK12.30701733
10HIPK22.22045088
11EPHB12.19737720
12EPHA22.14380907
13PIK3CA2.08236055
14NLK2.03454281
15MST1R1.96490221
16TAOK11.74493694
17ACVR1B1.70433826
18SIK11.62700193
19FGFR31.60930858
20TESK11.53551454
21TYK21.53295703
22CAMK1D1.52633468
23JAK11.51070168
24SIK21.45143103
25CHUK1.39080248
26JAK31.37853695
27MAP3K141.34075054
28ZAP701.33010237
29PRKD21.23523985
30DYRK1B1.22534191
31MAP3K101.21319164
32MAP3K11.20584285
33GRK61.17188597
34MARK21.17111542
35IKBKE1.16580221
36MET1.14628319
37TNK21.14302989
38CDK61.13820124
39ICK1.10994811
40BLK1.09534942
41PKN21.08093342
42DMPK1.05872412
43TBK11.05694277
44SGK31.02679004
45CAMK1G0.98302643
46FER0.96605612
47PRPF4B0.94197500
48IRAK10.93219036
49LRRK20.90980446
50SGK20.90714326
51KIT0.90568570
52JAK20.87887450
53PTK20.87637427
54MAPK70.86598566
55PDGFRA0.86525102
56MTOR0.84783545
57BTK0.81502592
58DDR20.79543279
59SGK2230.76672692
60SGK4940.76672692
61NTRK10.75962857
62CDK90.73551538
63LMTK20.71536698
64PDGFRB0.69502038
65SYK0.67761901
66TXK0.64620335
67MAP3K130.64506022
68BMX0.61188581
69SGK10.58841939
70RET0.56414028
71PTK60.52385543
72MAPK30.52063850
73MAP3K70.51948618
74RIPK40.51587922
75PRKD10.49610225
76CDK40.48709231
77STK380.48603912
78LYN0.48394883
79WNK10.47566706
80TEC0.46371764
81IKBKB0.45838121
82HCK0.44883031
83LCK0.43851609
84PRKCH0.43604061
85MAPK10.43544464
86MAP3K30.43037008
87MAP3K20.42090970
88MARK30.42061157
89STK390.41735293
90PDPK10.41448675
91MELK0.40859151
92YES10.39946795
93CSF1R0.39298897
94MAPK90.37340630
95ILK0.36812172
96MAPKAPK20.36248272
97EPHB20.33960632
98TRPM70.33824802
99BRD40.33789712
100MAPK100.33425032

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.67065007
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.50939492
3Allograft rejection_Homo sapiens_hsa053302.35954897
4Autoimmune thyroid disease_Homo sapiens_hsa053202.30439786
5Graft-versus-host disease_Homo sapiens_hsa053322.19779131
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15080046
7Staphylococcus aureus infection_Homo sapiens_hsa051502.11790489
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.00169793
9B cell receptor signaling pathway_Homo sapiens_hsa046621.95280114
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.92473053
11Primary immunodeficiency_Homo sapiens_hsa053401.86619283
12Viral myocarditis_Homo sapiens_hsa054161.82009275
13Acute myeloid leukemia_Homo sapiens_hsa052211.80964635
14Type I diabetes mellitus_Homo sapiens_hsa049401.67456650
15TNF signaling pathway_Homo sapiens_hsa046681.64977713
16Vitamin digestion and absorption_Homo sapiens_hsa049771.64791038
17Antigen processing and presentation_Homo sapiens_hsa046121.62245922
18Fat digestion and absorption_Homo sapiens_hsa049751.58477405
19Leishmaniasis_Homo sapiens_hsa051401.57184755
20Dorso-ventral axis formation_Homo sapiens_hsa043201.49154044
21Toxoplasmosis_Homo sapiens_hsa051451.47882663
22Influenza A_Homo sapiens_hsa051641.42326701
23Thyroid cancer_Homo sapiens_hsa052161.34899271
24Chemokine signaling pathway_Homo sapiens_hsa040621.33611097
25Adherens junction_Homo sapiens_hsa045201.29419065
26Circadian rhythm_Homo sapiens_hsa047101.29358948
27Hematopoietic cell lineage_Homo sapiens_hsa046401.27753006
28Notch signaling pathway_Homo sapiens_hsa043301.26868628
29Histidine metabolism_Homo sapiens_hsa003401.25529351
30Tuberculosis_Homo sapiens_hsa051521.24061546
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19504635
32Chronic myeloid leukemia_Homo sapiens_hsa052201.17446220
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14513070
34Renin-angiotensin system_Homo sapiens_hsa046141.09712023
35Herpes simplex infection_Homo sapiens_hsa051681.08525457
36Lysine degradation_Homo sapiens_hsa003101.05849818
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.02688505
38Sulfur metabolism_Homo sapiens_hsa009201.02495930
39Hepatitis C_Homo sapiens_hsa051601.00641735
40Prostate cancer_Homo sapiens_hsa052150.99840395
41Pancreatic cancer_Homo sapiens_hsa052120.99125307
42Hepatitis B_Homo sapiens_hsa051610.97808791
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97409238
44Measles_Homo sapiens_hsa051620.96664502
45Osteoclast differentiation_Homo sapiens_hsa043800.96135774
46Insulin resistance_Homo sapiens_hsa049310.95981178
47Rheumatoid arthritis_Homo sapiens_hsa053230.95179456
48Renal cell carcinoma_Homo sapiens_hsa052110.90250608
49Prolactin signaling pathway_Homo sapiens_hsa049170.88064546
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87491242
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.87227483
52Protein digestion and absorption_Homo sapiens_hsa049740.87146080
53Endometrial cancer_Homo sapiens_hsa052130.85791564
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85725082
55T cell receptor signaling pathway_Homo sapiens_hsa046600.83716395
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.82798923
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82037714
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81809449
59Malaria_Homo sapiens_hsa051440.78440744
60Mineral absorption_Homo sapiens_hsa049780.78383991
61Pertussis_Homo sapiens_hsa051330.76129793
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73941206
63HTLV-I infection_Homo sapiens_hsa051660.73385448
64Epstein-Barr virus infection_Homo sapiens_hsa051690.73054585
65Estrogen signaling pathway_Homo sapiens_hsa049150.70198353
66Pancreatic secretion_Homo sapiens_hsa049720.69239119
67Amoebiasis_Homo sapiens_hsa051460.69107688
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68656261
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67771149
70Non-small cell lung cancer_Homo sapiens_hsa052230.67258798
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67107635
72Colorectal cancer_Homo sapiens_hsa052100.66061370
73Linoleic acid metabolism_Homo sapiens_hsa005910.64946690
74African trypanosomiasis_Homo sapiens_hsa051430.60935498
75Small cell lung cancer_Homo sapiens_hsa052220.60807113
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58862637
77FoxO signaling pathway_Homo sapiens_hsa040680.58343779
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56892113
79Platelet activation_Homo sapiens_hsa046110.56800300
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54792401
81Choline metabolism in cancer_Homo sapiens_hsa052310.53873560
82Complement and coagulation cascades_Homo sapiens_hsa046100.53522607
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51882316
84Thyroid hormone synthesis_Homo sapiens_hsa049180.50222089
85Glucagon signaling pathway_Homo sapiens_hsa049220.50028383
86Phagosome_Homo sapiens_hsa041450.49995211
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.49123680
88Bladder cancer_Homo sapiens_hsa052190.45834197
89Viral carcinogenesis_Homo sapiens_hsa052030.45525853
90Apoptosis_Homo sapiens_hsa042100.44241109
91Focal adhesion_Homo sapiens_hsa045100.43976334
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42883654
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.42048968
94Proteoglycans in cancer_Homo sapiens_hsa052050.41235468
95Salmonella infection_Homo sapiens_hsa051320.41013088
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40925955
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40824559
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39764434
99Ether lipid metabolism_Homo sapiens_hsa005650.39619923
100Arachidonic acid metabolism_Homo sapiens_hsa005900.39605450

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