FDFT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cholesterol biosynthetic process (GO:0006695)6.43877391
2* sterol biosynthetic process (GO:0016126)5.69629305
3pyrimidine nucleobase catabolic process (GO:0006208)5.21825684
4fatty acid elongation (GO:0030497)4.75293004
5L-phenylalanine catabolic process (GO:0006559)4.50119270
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.50119270
7L-phenylalanine metabolic process (GO:0006558)4.17423931
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.17423931
9establishment of integrated proviral latency (GO:0075713)4.12528683
10* isoprenoid biosynthetic process (GO:0008299)3.97718244
11nucleobase catabolic process (GO:0046113)3.95252032
12piRNA metabolic process (GO:0034587)3.87102289
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.77238894
14alpha-linolenic acid metabolic process (GO:0036109)3.66919464
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65397032
16IMP biosynthetic process (GO:0006188)3.64142385
17sulfur amino acid catabolic process (GO:0000098)3.62832448
18fatty-acyl-CoA biosynthetic process (GO:0046949)3.60671159
19chromatin remodeling at centromere (GO:0031055)3.60222499
20coenzyme catabolic process (GO:0009109)3.59932052
21CENP-A containing nucleosome assembly (GO:0034080)3.49914113
22mitotic metaphase plate congression (GO:0007080)3.45499267
23DNA strand elongation involved in DNA replication (GO:0006271)3.44228074
24DNA damage response, detection of DNA damage (GO:0042769)3.40816217
25L-serine metabolic process (GO:0006563)3.40591855
26aromatic amino acid family catabolic process (GO:0009074)3.40346633
27purine nucleobase biosynthetic process (GO:0009113)3.38656455
28high-density lipoprotein particle remodeling (GO:0034375)3.36595239
29establishment of mitochondrion localization (GO:0051654)3.34075866
30DNA double-strand break processing (GO:0000729)3.33198665
31protein localization to kinetochore (GO:0034501)3.31449137
32cellular ketone body metabolic process (GO:0046950)3.31131205
33establishment of viral latency (GO:0019043)3.30458079
34DNA replication checkpoint (GO:0000076)3.29263481
35thioester biosynthetic process (GO:0035384)3.26940122
36acyl-CoA biosynthetic process (GO:0071616)3.26940122
37DNA strand elongation (GO:0022616)3.26574112
38cysteine metabolic process (GO:0006534)3.23389838
39serine family amino acid biosynthetic process (GO:0009070)3.21067854
40serine family amino acid catabolic process (GO:0009071)3.19928368
41long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.19810543
42glyoxylate metabolic process (GO:0046487)3.15457997
43tRNA aminoacylation for protein translation (GO:0006418)3.15282716
44negative regulation of DNA recombination (GO:0045910)3.14422113
45metaphase plate congression (GO:0051310)3.14329094
46telomere maintenance via semi-conservative replication (GO:0032201)3.12471714
47nucleobase biosynthetic process (GO:0046112)3.11761419
48DNA ligation (GO:0006266)3.11604971
49double-strand break repair via nonhomologous end joining (GO:0006303)3.10211457
50non-recombinational repair (GO:0000726)3.10211457
51regulation of cholesterol esterification (GO:0010872)3.09861818
52IMP metabolic process (GO:0046040)3.08363994
53amino acid activation (GO:0043038)3.08335127
54tRNA aminoacylation (GO:0043039)3.08335127
55acetyl-CoA metabolic process (GO:0006084)3.07282005
56acrosome reaction (GO:0007340)3.05890119
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.04444492
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04444492
59DNA replication-independent nucleosome organization (GO:0034724)3.04322319
60DNA replication-independent nucleosome assembly (GO:0006336)3.04322319
61cullin deneddylation (GO:0010388)3.01293998
62reverse cholesterol transport (GO:0043691)3.00210745
63histone exchange (GO:0043486)2.99922122
64fatty-acyl-CoA metabolic process (GO:0035337)2.99563242
65nuclear pore complex assembly (GO:0051292)2.98975520
66nuclear pore organization (GO:0006999)2.97620020
67axon ensheathment in central nervous system (GO:0032291)2.96833195
68central nervous system myelination (GO:0022010)2.96833195
69* steroid biosynthetic process (GO:0006694)2.96414231
70tyrosine metabolic process (GO:0006570)2.94835734
71regulation of cholesterol biosynthetic process (GO:0045540)2.92850232
72mitotic sister chromatid segregation (GO:0000070)2.90753354
73bile acid biosynthetic process (GO:0006699)2.89968208
74ketone body metabolic process (GO:1902224)2.89482228
75chaperone-mediated protein transport (GO:0072321)2.89256076
76histone H2A acetylation (GO:0043968)2.89182379
77glycine metabolic process (GO:0006544)2.89087128
78proteasome assembly (GO:0043248)2.88821283
79very long-chain fatty acid metabolic process (GO:0000038)2.86801266
80* cholesterol metabolic process (GO:0008203)2.86618235
81urea cycle (GO:0000050)2.85807598
82urea metabolic process (GO:0019627)2.85807598
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85442160
84regulation of mitotic spindle checkpoint (GO:1903504)2.85442160
85mitotic spindle checkpoint (GO:0071174)2.85301732
86DNA replication-dependent nucleosome organization (GO:0034723)2.85286538
87DNA replication-dependent nucleosome assembly (GO:0006335)2.85286538
88serine family amino acid metabolic process (GO:0009069)2.84998957
89sister chromatid segregation (GO:0000819)2.84995333
90cellular response to cholesterol (GO:0071397)2.84816257
91spindle checkpoint (GO:0031577)2.83154445
92linoleic acid metabolic process (GO:0043651)2.82768786
93negative regulation of chromosome segregation (GO:0051985)2.82192414
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81853500
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81853500
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81853500
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.81853500
98negative regulation of sister chromatid segregation (GO:0033046)2.81853500
99multicellular organism reproduction (GO:0032504)2.80234001
100negative regulation of fibrinolysis (GO:0051918)2.79359010
101sperm motility (GO:0030317)2.78846455
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78736788
103plasma lipoprotein particle remodeling (GO:0034369)2.77002426
104protein-lipid complex remodeling (GO:0034368)2.77002426
105macromolecular complex remodeling (GO:0034367)2.77002426
106arginine metabolic process (GO:0006525)2.75499521
107aldehyde catabolic process (GO:0046185)2.75253604
108DNA methylation involved in gamete generation (GO:0043046)2.74480277
109mitochondrion transport along microtubule (GO:0047497)2.72962860
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72962860
111aromatic amino acid family metabolic process (GO:0009072)2.72825990
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72486870
113microtubule depolymerization (GO:0007019)2.71248179
114protein deneddylation (GO:0000338)2.71145351
115mitotic nuclear envelope disassembly (GO:0007077)2.70761757
116binding of sperm to zona pellucida (GO:0007339)2.70497851
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70303414
118protein localization to chromosome, centromeric region (GO:0071459)2.69839010
119* sterol metabolic process (GO:0016125)2.69706470
120cofactor catabolic process (GO:0051187)2.69655523
121mitotic recombination (GO:0006312)2.69163422
122DNA topological change (GO:0006265)2.67420073
123acyl-CoA metabolic process (GO:0006637)2.67096934
124thioester metabolic process (GO:0035383)2.67096934
125RNA-dependent DNA replication (GO:0006278)2.67057354
126spliceosomal snRNP assembly (GO:0000387)2.65420668
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65199935
128male meiosis (GO:0007140)2.64296194
129glycerophospholipid catabolic process (GO:0046475)2.63026057
130neuron cell-cell adhesion (GO:0007158)2.62867455
131telomere maintenance via recombination (GO:0000722)2.62478202
132telomere maintenance via telomerase (GO:0007004)2.62208951
133sperm-egg recognition (GO:0035036)2.62165820
134telomere maintenance via telomere lengthening (GO:0010833)2.62095034
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.61567050
136coenzyme A metabolic process (GO:0015936)2.61476566
137regulation of helicase activity (GO:0051095)2.60801308
138nitrogen cycle metabolic process (GO:0071941)2.59920679
139triglyceride biosynthetic process (GO:0019432)2.59919060
140DNA unwinding involved in DNA replication (GO:0006268)2.59515086
141mitotic spindle assembly checkpoint (GO:0007094)2.58723587
142plasma lipoprotein particle clearance (GO:0034381)2.58356182
143peptidyl-arginine omega-N-methylation (GO:0035247)2.58080564
144regulation of double-strand break repair via homologous recombination (GO:0010569)2.57856478
145alpha-amino acid catabolic process (GO:1901606)2.57094059
146* alcohol biosynthetic process (GO:0046165)2.56523700
147regulation of chromosome segregation (GO:0051983)2.55155471
148regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55131778
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55131778
150heme transport (GO:0015886)2.54806223
151negative regulation of microtubule polymerization (GO:0031115)2.54617687
152ATP-dependent chromatin remodeling (GO:0043044)2.54053224
153long-chain fatty acid biosynthetic process (GO:0042759)2.53912426
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.53267203
155spindle assembly checkpoint (GO:0071173)2.53165388
156kinetochore assembly (GO:0051382)2.52910338
157kinetochore organization (GO:0051383)2.52761229
158bile acid metabolic process (GO:0008206)2.52693077
159regulation of centriole replication (GO:0046599)2.52555700
160establishment of chromosome localization (GO:0051303)2.52532792
161cell migration in hindbrain (GO:0021535)2.51793076
162neutral lipid biosynthetic process (GO:0046460)2.51765066
163acylglycerol biosynthetic process (GO:0046463)2.51765066
164kynurenine metabolic process (GO:0070189)2.51649373
165low-density lipoprotein particle remodeling (GO:0034374)2.51601213
166DNA replication initiation (GO:0006270)2.51442599
167cellular amino acid catabolic process (GO:0009063)2.51071629
168arginine catabolic process (GO:0006527)2.50692997
169peroxisome fission (GO:0016559)2.50653339
170microtubule polymerization or depolymerization (GO:0031109)2.50538732
171regulation of mitotic sister chromatid segregation (GO:0033047)2.50524545
172regulation of sister chromatid segregation (GO:0033045)2.50524545
173regulation of mitotic sister chromatid separation (GO:0010965)2.50524545
174regulation of fibrinolysis (GO:0051917)2.50341803
175DNA catabolic process, exonucleolytic (GO:0000738)2.50309901
176ethanol oxidation (GO:0006069)2.50298442
177tryptophan catabolic process (GO:0006569)2.49358628
178indole-containing compound catabolic process (GO:0042436)2.49358628
179indolalkylamine catabolic process (GO:0046218)2.49358628
180base-excision repair (GO:0006284)2.49088776
181nuclear envelope disassembly (GO:0051081)2.48366463
182membrane disassembly (GO:0030397)2.48366463
183resolution of meiotic recombination intermediates (GO:0000712)2.47903474
184fusion of sperm to egg plasma membrane (GO:0007342)2.47698164
185ribosome assembly (GO:0042255)2.47102499
186replication fork processing (GO:0031297)2.46281355
187DNA strand renaturation (GO:0000733)2.45970411
188synapsis (GO:0007129)2.45770073
189histone arginine methylation (GO:0034969)2.45175503
190negative regulation of ligase activity (GO:0051352)2.44566725
191homocysteine metabolic process (GO:0050667)2.44220013
192very-low-density lipoprotein particle assembly (GO:0034379)2.43363948
193CDP-diacylglycerol metabolic process (GO:0046341)2.41413727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.94283414
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.98275262
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59083315
4EZH2_22144423_ChIP-Seq_EOC_Human3.34202357
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.26781992
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.01990224
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.00441384
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.94541136
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90455757
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.89907182
11* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64004190
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63379712
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57457708
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.55329457
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50815885
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43461811
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.37903014
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37793614
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32881684
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32451486
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28432232
22ELK1_19687146_ChIP-ChIP_HELA_Human2.16195544
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14414391
24EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14017403
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13488260
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12946559
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12936948
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12253009
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11808268
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10402675
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08393846
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03512322
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03050892
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.99414312
35AR_21909140_ChIP-Seq_LNCAP_Human1.97150706
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95193355
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94233021
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94176778
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92855254
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91228994
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86726597
42FOXP3_21729870_ChIP-Seq_TREG_Human1.80805309
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79991774
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77135279
45GABP_19822575_ChIP-Seq_HepG2_Human1.76801949
46DCP1A_22483619_ChIP-Seq_HELA_Human1.76799940
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.76595571
48XRN2_22483619_ChIP-Seq_HELA_Human1.75691048
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74183502
50VDR_23849224_ChIP-Seq_CD4+_Human1.73874900
51TAF15_26573619_Chip-Seq_HEK293_Human1.73826724
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71279465
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69243865
54TTF2_22483619_ChIP-Seq_HELA_Human1.67993620
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66579000
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60640453
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55931332
58* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54191227
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.53427420
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.52070206
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50521395
62GBX2_23144817_ChIP-Seq_PC3_Human1.49605420
63HTT_18923047_ChIP-ChIP_STHdh_Human1.49129075
64MYC_18940864_ChIP-ChIP_HL60_Human1.48699500
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.47863456
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47006573
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46459657
68REST_21632747_ChIP-Seq_MESCs_Mouse1.46105510
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44875876
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44372830
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41685896
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.41002948
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39751990
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39303779
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37528752
76ZNF263_19887448_ChIP-Seq_K562_Human1.31667855
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.30941162
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30718989
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30231044
80* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29889823
81EWS_26573619_Chip-Seq_HEK293_Human1.29800314
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.26958917
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25500499
84IRF1_19129219_ChIP-ChIP_H3396_Human1.23090995
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.19724505
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18877486
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16354467
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16305530
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16012854
90KDM5A_27292631_Chip-Seq_BREAST_Human1.14477032
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.12636544
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12604825
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11499096
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11281840
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08006849
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07733994
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06178216
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05724071
99* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04777675
100RNF2_27304074_Chip-Seq_NSC_Mouse1.04546166
101ZNF274_21170338_ChIP-Seq_K562_Hela1.04237347
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03761116
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01665740
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01373776
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00704766
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00339387
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99629481
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99540078
109VDR_22108803_ChIP-Seq_LS180_Human0.97802170
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97693460
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.97526570
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97524095
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95418746
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.95069577
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.94353387
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94082993
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93194300
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92797551
119* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92346852
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91996572
121AR_21572438_ChIP-Seq_LNCaP_Human0.91922810
122EZH2_27304074_Chip-Seq_ESCs_Mouse0.91806940
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91470857
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90298726
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90039774
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89543910
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88856211
128P300_19829295_ChIP-Seq_ESCs_Human0.88635319
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88574195
130IGF1R_20145208_ChIP-Seq_DFB_Human0.87215006
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85791153
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85760498
133* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84679806
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.82914142
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82739726
136SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81706835
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.80862907
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80836199
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80417956
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80137854
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79527012
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.78963940
143JUN_21703547_ChIP-Seq_K562_Human0.78712868
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78419307
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77903066
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.77654458
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77383707
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.77165925
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.76929732
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76874412
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76735094
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.76611939
153FUS_26573619_Chip-Seq_HEK293_Human0.76491675
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76321972
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75658955
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75502966
157AR_25329375_ChIP-Seq_VCAP_Human0.75480802
158* SOX9_26525672_Chip-Seq_HEART_Mouse0.74798270
159KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74534149
160KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74534149
161SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73556437
162NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73473851
163TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72673873
164SMAD4_21799915_ChIP-Seq_A2780_Human0.71882075
165NCOR_22424771_ChIP-Seq_293T_Human0.71768451
166POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.71612517
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71372014
168MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71251862
169EED_16625203_ChIP-ChIP_MESCs_Mouse0.71130041
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70682655
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70682655
172OCT4_20526341_ChIP-Seq_ESCs_Human0.70580546
173SOX2_22085726_ChIP-Seq_NPCs_Mouse0.70540291
174YY1_22570637_ChIP-Seq_MALME-3M_Human0.70346246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.78172274
2MP0003806_abnormal_nucleotide_metabolis3.62072064
3MP0005360_urolithiasis3.28301281
4MP0003693_abnormal_embryo_hatching3.12968501
5MP0003122_maternal_imprinting3.08980853
6MP0008058_abnormal_DNA_repair3.05389904
7MP0010094_abnormal_chromosome_stability3.01806043
8MP0005085_abnormal_gallbladder_physiolo2.90285795
9MP0005410_abnormal_fertilization2.82922462
10MP0005365_abnormal_bile_salt2.76906893
11MP0003111_abnormal_nucleus_morphology2.69930857
12MP0004957_abnormal_blastocyst_morpholog2.65540891
13MP0003718_maternal_effect2.59009796
14MP0003329_amyloid_beta_deposits2.53050812
15MP0008875_abnormal_xenobiotic_pharmacok2.50626264
16MP0009840_abnormal_foam_cell2.50534260
17MP0004270_analgesia2.40160783
18MP0003121_genomic_imprinting2.40157339
19MP0008932_abnormal_embryonic_tissue2.39076764
20MP0006292_abnormal_olfactory_placode2.34751367
21MP0006276_abnormal_autonomic_nervous2.27252354
22MP0003941_abnormal_skin_development2.10822372
23MP0003077_abnormal_cell_cycle2.08491493
24MP0005499_abnormal_olfactory_system2.04331421
25MP0005394_taste/olfaction_phenotype2.04331421
26MP0001529_abnormal_vocalization2.00435361
27MP0008789_abnormal_olfactory_epithelium2.00136125
28MP0005083_abnormal_biliary_tract1.99335327
29MP0003011_delayed_dark_adaptation1.99314032
30MP0002938_white_spotting1.98143250
31MP0008260_abnormal_autophagy1.85367757
32MP0001968_abnormal_touch/_nociception1.83453343
33MP0008007_abnormal_cellular_replicative1.79232333
34MP0003880_abnormal_central_pattern1.79008740
35MP0002653_abnormal_ependyma_morphology1.76956930
36MP0000778_abnormal_nervous_system1.76527718
37MP0002736_abnormal_nociception_after1.73458850
38MP0002734_abnormal_mechanical_nocicepti1.72277533
39MP0001293_anophthalmia1.71071297
40MP0003787_abnormal_imprinting1.68997354
41MP0001905_abnormal_dopamine_level1.64970272
42MP0010329_abnormal_lipoprotein_level1.64029130
43MP0003567_abnormal_fetal_cardiomyocyte1.63652125
44MP0009672_abnormal_birth_weight1.63013667
45MP0002733_abnormal_thermal_nociception1.58126015
46MP0008057_abnormal_DNA_replication1.57761338
47MP0001440_abnormal_grooming_behavior1.54793604
48MP0005332_abnormal_amino_acid1.53136569
49MP0001188_hyperpigmentation1.52448082
50MP0009697_abnormal_copulation1.45724488
51MP0003195_calcinosis1.44366488
52MP0004858_abnormal_nervous_system1.43310390
53MP0006072_abnormal_retinal_apoptosis1.38858795
54MP0002735_abnormal_chemical_nociception1.37958399
55MP0003698_abnormal_male_reproductive1.35980298
56MP0001730_embryonic_growth_arrest1.32355727
57MP0000604_amyloidosis1.32228778
58MP0004885_abnormal_endolymph1.29244923
59MP0002233_abnormal_nose_morphology1.28632967
60MP0001929_abnormal_gametogenesis1.24919772
61MP0003119_abnormal_digestive_system1.23694299
62MP0006035_abnormal_mitochondrial_morpho1.23280854
63MP0003656_abnormal_erythrocyte_physiolo1.22186533
64MP0005451_abnormal_body_composition1.17864501
65MP0004147_increased_porphyrin_level1.15072257
66MP0009703_decreased_birth_body1.13744940
67MP0010030_abnormal_orbit_morphology1.13003973
68MP0003786_premature_aging1.12409733
69MP0002234_abnormal_pharynx_morphology1.11747511
70MP0001286_abnormal_eye_development1.11641575
71MP0002084_abnormal_developmental_patter1.11566227
72MP0002118_abnormal_lipid_homeostasis1.11046255
73MP0003123_paternal_imprinting1.10398945
74MP0008877_abnormal_DNA_methylation1.10300867
75* MP0001672_abnormal_embryogenesis/_devel1.09119672
76* MP0005380_embryogenesis_phenotype1.09119672
77* MP0002085_abnormal_embryonic_tissue1.08026109
78MP0000579_abnormal_nail_morphology1.07241873
79MP0002063_abnormal_learning/memory/cond1.06273835
80MP0001970_abnormal_pain_threshold1.05881741
81MP0000647_abnormal_sebaceous_gland1.05794792
82MP0000631_abnormal_neuroendocrine_gland1.05744350
83MP0003635_abnormal_synaptic_transmissio1.05445819
84MP0001697_abnormal_embryo_size1.05058763
85MP0004142_abnormal_muscle_tone1.04565450
86MP0002697_abnormal_eye_size1.04071456
87MP0003315_abnormal_perineum_morphology1.03695589
88MP0000537_abnormal_urethra_morphology1.02726899
89MP0004197_abnormal_fetal_growth/weight/1.02718703
90MP0001984_abnormal_olfaction1.02411383
91MP0001486_abnormal_startle_reflex1.02352509
92MP0005253_abnormal_eye_physiology1.02073233
93MP0000350_abnormal_cell_proliferation1.01910784
94MP0002161_abnormal_fertility/fecundity0.99768183
95MP0005395_other_phenotype0.99261470
96MP0002572_abnormal_emotion/affect_behav0.98218110
97MP0003868_abnormal_feces_composition0.97941586
98MP0001299_abnormal_eye_distance/0.97635134
99MP0003755_abnormal_palate_morphology0.97397783
100MP0002210_abnormal_sex_determination0.97205433
101MP0000049_abnormal_middle_ear0.96634857
102MP0005646_abnormal_pituitary_gland0.96557761
103MP0000566_synostosis0.95764179
104MP0000955_abnormal_spinal_cord0.95103616
105MP0004133_heterotaxia0.94647587
106MP0003136_yellow_coat_color0.94647192
107* MP0002080_prenatal_lethality0.93446324
108MP0002184_abnormal_innervation0.93375027
109MP0001485_abnormal_pinna_reflex0.92420095
110MP0003690_abnormal_glial_cell0.92070437
111MP0003634_abnormal_glial_cell0.92031082
112MP0004859_abnormal_synaptic_plasticity0.92018604
113MP0008995_early_reproductive_senescence0.91725198
114MP0002111_abnormal_tail_morphology0.91182052
115MP0005647_abnormal_sex_gland0.90670197
116MP0005423_abnormal_somatic_nervous0.88433586
117MP0003632_abnormal_nervous_system0.88337217
118MP0000653_abnormal_sex_gland0.87341837
119MP0002822_catalepsy0.87048691
120MP0004924_abnormal_behavior0.86809232
121MP0005386_behavior/neurological_phenoty0.86809232
122MP0002882_abnormal_neuron_morphology0.85030777
123MP0002557_abnormal_social/conspecific_i0.85023810
124MP0002638_abnormal_pupillary_reflex0.84128228
125* MP0003984_embryonic_growth_retardation0.83857541
126MP0003937_abnormal_limbs/digits/tail_de0.83003322
127MP0005391_vision/eye_phenotype0.81755903
128MP0002064_seizures0.81659178
129* MP0002088_abnormal_embryonic_growth/wei0.81544909
130MP0003646_muscle_fatigue0.80762322
131MP0009745_abnormal_behavioral_response0.79464042
132MP0002272_abnormal_nervous_system0.79060051
133MP0000462_abnormal_digestive_system0.78440090
134MP0004019_abnormal_vitamin_homeostasis0.78338802
135MP0001145_abnormal_male_reproductive0.78069136
136MP0002067_abnormal_sensory_capabilities0.77738451
137MP0003938_abnormal_ear_development0.76854922
138MP0001666_abnormal_nutrient_absorption0.76748781
139MP0000372_irregular_coat_pigmentation0.76105243
140MP0000358_abnormal_cell_content/0.75129267
141MP0005551_abnormal_eye_electrophysiolog0.74783374
142MP0000538_abnormal_urinary_bladder0.74536172
143MP0005187_abnormal_penis_morphology0.74234454
144MP0005645_abnormal_hypothalamus_physiol0.74208343
145MP0002160_abnormal_reproductive_system0.74027649
146MP0002752_abnormal_somatic_nervous0.73695486
147MP0001177_atelectasis0.73605636
148MP0002152_abnormal_brain_morphology0.73433092
149MP0002066_abnormal_motor_capabilities/c0.72881627
150MP0004742_abnormal_vestibular_system0.71625043
151* MP0003861_abnormal_nervous_system0.71042198
152MP0005248_abnormal_Harderian_gland0.69749195
153MP0000920_abnormal_myelination0.69541558
154MP0003221_abnormal_cardiomyocyte_apopto0.69164720
155MP0003890_abnormal_embryonic-extraembry0.68274569
156MP0001764_abnormal_homeostasis0.68114099
157MP0002751_abnormal_autonomic_nervous0.68039726
158MP0002282_abnormal_trachea_morphology0.67627527
159MP0003252_abnormal_bile_duct0.67027839
160MP0003385_abnormal_body_wall0.66574969
161MP0001324_abnormal_eye_pigmentation0.65911416
162MP0004811_abnormal_neuron_physiology0.65870816
163MP0003699_abnormal_female_reproductive0.65782154
164MP0009250_abnormal_appendicular_skeleto0.65736333
165MP0002102_abnormal_ear_morphology0.64687869

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.28522058
2Abnormality of glycolysis (HP:0004366)4.28522058
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.78537986
4Hyperglycinemia (HP:0002154)3.69387714
5Intrahepatic cholestasis (HP:0001406)3.59390420
6Neurofibrillary tangles (HP:0002185)3.59339757
7Xanthomatosis (HP:0000991)3.51116413
8Deep venous thrombosis (HP:0002625)3.45849619
9Hypobetalipoproteinemia (HP:0003563)3.29287174
10Colon cancer (HP:0003003)3.14554941
11Abnormal lung lobation (HP:0002101)3.12118193
12Cerebral inclusion bodies (HP:0100314)3.00590339
13Abnormality of serine family amino acid metabolism (HP:0010894)2.94764572
14Abnormality of glycine metabolism (HP:0010895)2.94764572
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91408643
16Hypoplastic pelvis (HP:0008839)2.88778031
17Abnormality of monocarboxylic acid metabolism (HP:0010996)2.85465486
18Epidermoid cyst (HP:0200040)2.82785943
19Hyperlipoproteinemia (HP:0010980)2.75704950
20Myokymia (HP:0002411)2.75348015
21Abnormality of the corticospinal tract (HP:0002492)2.73564408
22Abnormality of the labia minora (HP:0012880)2.73557866
23Chromsome breakage (HP:0040012)2.73124021
24Cholecystitis (HP:0001082)2.70963677
25Abnormal gallbladder physiology (HP:0012438)2.70963677
26Parakeratosis (HP:0001036)2.70480526
27Termporal pattern (HP:0011008)2.66490119
28Insidious onset (HP:0003587)2.66490119
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64457298
30Broad alveolar ridges (HP:0000187)2.60460564
31Pheochromocytoma (HP:0002666)2.57511113
32Meckel diverticulum (HP:0002245)2.57157964
33Poor suck (HP:0002033)2.56679010
34Delusions (HP:0000746)2.56487101
35Hypolipoproteinemia (HP:0010981)2.54917674
36Hyperglycinuria (HP:0003108)2.53817887
37Abnormality of the ileum (HP:0001549)2.48266648
38Cerebral hypomyelination (HP:0006808)2.39525785
39Morphological abnormality of the pyramidal tract (HP:0002062)2.39179961
40Ependymoma (HP:0002888)2.38111459
41Abnormality of serum amino acid levels (HP:0003112)2.37457204
42Prolonged partial thromboplastin time (HP:0003645)2.35180319
43Increased nuchal translucency (HP:0010880)2.31850981
44Adrenal hypoplasia (HP:0000835)2.30763267
45Medulloblastoma (HP:0002885)2.30475858
46Megalencephaly (HP:0001355)2.29902740
47Limb dystonia (HP:0002451)2.29221311
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.29098965
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29098965
50Abnormality of methionine metabolism (HP:0010901)2.28510639
51Bifid tongue (HP:0010297)2.26238117
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.25582383
53Abnormality of the metopic suture (HP:0005556)2.25439357
54Overlapping toe (HP:0001845)2.25077445
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.24871713
56Hypoalphalipoproteinemia (HP:0003233)2.22228238
57Abnormal hair whorl (HP:0010721)2.21815905
58Abnormality of placental membranes (HP:0011409)2.21646135
59Amniotic constriction ring (HP:0009775)2.21646135
60Hypoplastic female external genitalia (HP:0012815)2.21457402
61Nephroblastoma (Wilms tumor) (HP:0002667)2.21447844
62Septo-optic dysplasia (HP:0100842)2.21371744
63Irritability (HP:0000737)2.21205521
64Facial hemangioma (HP:0000329)2.20712898
65Impulsivity (HP:0100710)2.20028851
66Irregular epiphyses (HP:0010582)2.16649240
67Congenital ichthyosiform erythroderma (HP:0007431)2.16101900
68Generalized hypotonia (HP:0001290)2.14407498
69Methylmalonic acidemia (HP:0002912)2.14355124
70Scrotal hypoplasia (HP:0000046)2.14159553
71Multiple enchondromatosis (HP:0005701)2.13328690
72Abnormality of chromosome stability (HP:0003220)2.13114580
73Polyphagia (HP:0002591)2.12964591
74Labial hypoplasia (HP:0000066)2.12782331
75Microglossia (HP:0000171)2.11460499
76Embryonal renal neoplasm (HP:0011794)2.10815756
77Abnormality of the preputium (HP:0100587)2.10031932
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.10014818
79Hyperammonemia (HP:0001987)2.09471650
80Birth length less than 3rd percentile (HP:0003561)2.07774074
81Neuroendocrine neoplasm (HP:0100634)2.07356494
82Aplasia involving bones of the upper limbs (HP:0009823)2.07269102
83Aplasia of the phalanges of the hand (HP:0009802)2.07269102
84Aplasia involving bones of the extremities (HP:0009825)2.07269102
85Cortical dysplasia (HP:0002539)2.06651776
86Hypophosphatemic rickets (HP:0004912)2.06149518
87Prominent metopic ridge (HP:0005487)2.03539942
88Absent/shortened dynein arms (HP:0200106)2.02355611
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.02355611
90Hepatoblastoma (HP:0002884)2.01511520
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01109869
92Acute encephalopathy (HP:0006846)2.00710468
93Spastic tetraparesis (HP:0001285)2.00306158
94Duodenal stenosis (HP:0100867)1.98203829
95Small intestinal stenosis (HP:0012848)1.98203829
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96734689
97Pancreatic islet-cell hyperplasia (HP:0004510)1.93452376
98Abnormality of the labia (HP:0000058)1.92753852
99Infertility (HP:0000789)1.91691677
100Neoplasm of the adrenal gland (HP:0100631)1.90588647
101Volvulus (HP:0002580)1.88954892
102Lissencephaly (HP:0001339)1.88683431
103Postnatal microcephaly (HP:0005484)1.88258247
104Abnormality of the duodenum (HP:0002246)1.87249111
105Abnormal gallbladder morphology (HP:0012437)1.85546427
106Supranuclear gaze palsy (HP:0000605)1.85176204
107Ankle clonus (HP:0011448)1.84880464
108Acute necrotizing encephalopathy (HP:0006965)1.84388179
109Lethargy (HP:0001254)1.82109359
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80930583
111Renal hypoplasia (HP:0000089)1.80865320
112Degeneration of anterior horn cells (HP:0002398)1.78262094
113Abnormality of the anterior horn cell (HP:0006802)1.78262094
114Spastic paraparesis (HP:0002313)1.77720515
115Horseshoe kidney (HP:0000085)1.77111288
116Abnormality of the astrocytes (HP:0100707)1.75748471
117Astrocytoma (HP:0009592)1.75748471
118Glioma (HP:0009733)1.75650479
119Methylmalonic aciduria (HP:0012120)1.75358752
120Abnormal respiratory epithelium morphology (HP:0012253)1.75081054
121Abnormal respiratory motile cilium morphology (HP:0005938)1.75081054
122Gout (HP:0001997)1.74542846
123Hypsarrhythmia (HP:0002521)1.73095894
124Abnormality of the gallbladder (HP:0005264)1.72395744
125Rhabdomyosarcoma (HP:0002859)1.72374269
126Spastic diplegia (HP:0001264)1.72226106
127Upper limb muscle weakness (HP:0003484)1.71839471
128Sloping forehead (HP:0000340)1.71295818
129Hemivertebrae (HP:0002937)1.71230593
130Abnormal respiratory motile cilium physiology (HP:0012261)1.70461102
131Ketosis (HP:0001946)1.70425365
132Microvesicular hepatic steatosis (HP:0001414)1.70344499
133Supernumerary spleens (HP:0009799)1.69476890
134Fat malabsorption (HP:0002630)1.69439840
135Spastic gait (HP:0002064)1.69269867
136Spastic tetraplegia (HP:0002510)1.68891929
137Myelomeningocele (HP:0002475)1.68228185
138Abnormal mitochondria in muscle tissue (HP:0008316)1.68086794
139Male infertility (HP:0003251)1.67912546
140Hypoglycemic coma (HP:0001325)1.67541817
141Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67532199
142Delayed myelination (HP:0012448)1.67507244
143Absent septum pellucidum (HP:0001331)1.67156994
144Pendular nystagmus (HP:0012043)1.65959820
145EEG with generalized epileptiform discharges (HP:0011198)1.64896931
146Septate vagina (HP:0001153)1.64653387
147Aplasia of the musculature (HP:0100854)1.64240046
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.62283745
149Abnormality of pyrimidine metabolism (HP:0004353)1.61977305
150Back pain (HP:0003418)1.61684375
151Bicornuate uterus (HP:0000813)1.61617734
152Enlarged kidneys (HP:0000105)1.61585148
153Dandy-Walker malformation (HP:0001305)1.61488032
154Intestinal atresia (HP:0011100)1.61303738
155Cerebral edema (HP:0002181)1.61047327
156Increased serum lactate (HP:0002151)1.60145395
157Abnormality of the clitoris (HP:0000056)1.60051286
158Failure to thrive in infancy (HP:0001531)1.58481342
159Brittle hair (HP:0002299)1.58085046
160Hypoplastic left heart (HP:0004383)1.57950805
161Clonus (HP:0002169)1.57909250
162Akinesia (HP:0002304)1.57875681
163Epileptiform EEG discharges (HP:0011182)1.57694929
164Acanthocytosis (HP:0001927)1.56811794
165Abnormality of endocrine pancreas physiology (HP:0012093)1.56671486
166Abnormality of the pancreatic islet cells (HP:0006476)1.56671486
167Humeroradial synostosis (HP:0003041)1.56653815
168Synostosis involving the elbow (HP:0003938)1.56653815
169Preaxial hand polydactyly (HP:0001177)1.56102244
170Retinal dysplasia (HP:0007973)1.55917018
171Abnormality of the parathyroid morphology (HP:0011766)1.54847935
172High anterior hairline (HP:0009890)1.53222277
173Brushfield spots (HP:0001088)1.53206401
174Proximal placement of thumb (HP:0009623)1.51426743
175Abnormality of the alveolar ridges (HP:0006477)1.50495056
176Carpal bone hypoplasia (HP:0001498)1.50284886
177Triphalangeal thumb (HP:0001199)1.49673657
178Shoulder girdle muscle weakness (HP:0003547)1.49036508
179Abnormality of the septum pellucidum (HP:0007375)1.49013033
180Embryonal neoplasm (HP:0002898)1.48969344
181Absent radius (HP:0003974)1.48153174
182Micropenis (HP:0000054)1.48085057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.02111601
2MARK13.31634479
3SRPK13.18330533
4CDC72.68079047
5PDK42.67158291
6PDK32.67158291
7MAP4K22.66052054
8TRIM282.62882281
9BCR2.60379690
10DYRK22.43266094
11EIF2AK32.26601955
12VRK22.25662415
13STK392.22937955
14WNK32.16781538
15MKNK12.14296016
16LATS22.05511853
17MKNK22.01934855
18ZAK1.93571620
19CASK1.91330489
20NUAK11.90098387
21LIMK11.86948976
22WEE11.84443007
23NTRK21.77836181
24PDK21.77428932
25BUB11.74636186
26MINK11.65859502
27BRSK21.64735290
28PHKG21.62361571
29PHKG11.62361571
30TESK11.60156094
31LMTK21.56215674
32TNIK1.55209074
33MAPK131.54115402
34VRK11.51561764
35PNCK1.49714968
36MAP3K91.45591120
37MAP3K41.42667736
38STK38L1.41577831
39NTRK11.41341700
40TYRO31.41255423
41ERBB41.38406247
42PRKD31.38347689
43BCKDK1.35377319
44MST41.35080773
45BMPR1B1.34197200
46FGFR21.34182729
47KSR11.30203940
48TESK21.28815329
49CSNK1G31.25585846
50ARAF1.25551754
51CSNK1G21.22973945
52KSR21.15781838
53OXSR11.13956610
54PLK21.12901755
55ATR1.12098350
56TAF11.10839374
57EPHA41.07447148
58PAK61.07039608
59ACVR1B1.04104174
60NEK21.03821515
61MET1.03556012
62BRAF1.01791220
63AURKA1.00372447
64MAP2K70.98178659
65PRKCG0.97524325
66PLK40.97358730
67PAK30.96942299
68CSNK1G10.95331944
69PINK10.95296057
70MAP2K40.95160002
71SGK2230.94100645
72SGK4940.94100645
73PBK0.92695059
74DYRK30.90870622
75UHMK10.89387936
76PASK0.88509880
77EIF2AK10.88143632
78CDK140.86646849
79ICK0.85601667
80ATM0.84653627
81CHEK10.82185202
82AURKB0.80134126
83CDK180.80051514
84PRPF4B0.77587957
85SIK30.74998586
86EPHB20.74669561
87DYRK1A0.74349329
88CDK150.72763261
89CSNK1A1L0.71611079
90PKN10.70820913
91CLK10.70563009
92CDK190.70067530
93WNK40.68758845
94PLK30.68553827
95LATS10.67845084
96CCNB10.67240810
97MAP2K10.65285719
98YES10.65225273
99EIF2AK20.63877477
100AKT30.63872162
101RPS6KA40.62527420
102PRKCZ0.61598170
103CDK70.59989088
104CDK11A0.59463278
105TGFBR10.58450942
106EPHB10.58126179
107TSSK60.57318175
108ADRBK10.56921961
109BRD40.56544007
110CAMK2A0.56532558
111EPHA30.56449577
112CDK10.56356099
113CHEK20.55577979
114GRK50.55090798
115CAMK2G0.53517143
116FER0.53014813
117TTK0.52860656
118SIK10.52297529
119ERBB30.52003307
120CDK50.51493124
121STK30.51142440
122FGFR40.51024626
123EPHA20.50403026
124RAF10.50114311
125NME10.49925421
126CSNK1E0.49323094
127MAPKAPK50.47975135
128CDK20.47862415
129ALK0.47546246
130PLK10.47140037
131PRKDC0.46216020
132ERBB20.46033172
133RET0.45177530
134DAPK20.44148276
135FGFR10.43881194
136STK160.43847203
137BRSK10.43757178
138CAMK1G0.43756020
139CAMK2B0.43337775
140CSNK2A10.42112480
141ABL20.41660531
142MAP3K100.41035899
143PRKCI0.40333786
144CSNK2A20.39799721
145CSNK1A10.37733266
146FLT30.34197304
147PAK40.33253361
148STK40.31565839

Predicted pathways (KEGG)

RankGene SetZ-score
1* Steroid biosynthesis_Homo sapiens_hsa001004.55780371
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.24120550
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.85679583
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.25388879
5Vitamin B6 metabolism_Homo sapiens_hsa007502.85429593
6Mismatch repair_Homo sapiens_hsa034302.63552181
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58795528
8Butanoate metabolism_Homo sapiens_hsa006502.58187181
9Nitrogen metabolism_Homo sapiens_hsa009102.51563632
10DNA replication_Homo sapiens_hsa030302.48198545
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40282506
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38143533
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.37221325
14Non-homologous end-joining_Homo sapiens_hsa034502.32026879
15Fatty acid elongation_Homo sapiens_hsa000622.21313957
16Fatty acid metabolism_Homo sapiens_hsa012122.09995903
17Protein export_Homo sapiens_hsa030602.08197629
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95383908
19Base excision repair_Homo sapiens_hsa034101.93536023
20Propanoate metabolism_Homo sapiens_hsa006401.88267378
21Fatty acid degradation_Homo sapiens_hsa000711.84145254
22Arginine biosynthesis_Homo sapiens_hsa002201.74717421
23Spliceosome_Homo sapiens_hsa030401.74668432
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68803376
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68762170
26Pyruvate metabolism_Homo sapiens_hsa006201.67853747
27Homologous recombination_Homo sapiens_hsa034401.67283907
28Fanconi anemia pathway_Homo sapiens_hsa034601.66236983
29One carbon pool by folate_Homo sapiens_hsa006701.64834392
30Fatty acid biosynthesis_Homo sapiens_hsa000611.64325879
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62288071
32Sulfur metabolism_Homo sapiens_hsa009201.60868350
33Tryptophan metabolism_Homo sapiens_hsa003801.57775873
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55671208
35Cell cycle_Homo sapiens_hsa041101.54642102
36Nucleotide excision repair_Homo sapiens_hsa034201.43220154
37RNA degradation_Homo sapiens_hsa030181.42444961
38Histidine metabolism_Homo sapiens_hsa003401.41189863
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.39824590
40Peroxisome_Homo sapiens_hsa041461.38537290
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37948465
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.35811126
43Tyrosine metabolism_Homo sapiens_hsa003501.34686303
44Biosynthesis of amino acids_Homo sapiens_hsa012301.31034799
45Chemical carcinogenesis_Homo sapiens_hsa052041.27231521
46Phenylalanine metabolism_Homo sapiens_hsa003601.23163972
47PPAR signaling pathway_Homo sapiens_hsa033201.22060033
48Proteasome_Homo sapiens_hsa030501.16699455
49Complement and coagulation cascades_Homo sapiens_hsa046101.15816103
50Retinol metabolism_Homo sapiens_hsa008301.14220716
51mRNA surveillance pathway_Homo sapiens_hsa030151.13609442
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12172589
53Carbon metabolism_Homo sapiens_hsa012001.09247026
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07165346
55Ether lipid metabolism_Homo sapiens_hsa005651.05007111
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03862773
57Folate biosynthesis_Homo sapiens_hsa007901.00944030
58Fat digestion and absorption_Homo sapiens_hsa049751.00758649
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.99049695
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.98807022
61Selenocompound metabolism_Homo sapiens_hsa004500.97062609
62Linoleic acid metabolism_Homo sapiens_hsa005910.96634871
63Pyrimidine metabolism_Homo sapiens_hsa002400.96361063
64Arginine and proline metabolism_Homo sapiens_hsa003300.95564786
65Bile secretion_Homo sapiens_hsa049760.94676357
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94192509
67beta-Alanine metabolism_Homo sapiens_hsa004100.92906734
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86584633
69Pentose phosphate pathway_Homo sapiens_hsa000300.83688861
70Purine metabolism_Homo sapiens_hsa002300.80929469
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79084200
72Sulfur relay system_Homo sapiens_hsa041220.74270124
73Glutathione metabolism_Homo sapiens_hsa004800.73146407
74Synaptic vesicle cycle_Homo sapiens_hsa047210.72636767
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69921656
76Vitamin digestion and absorption_Homo sapiens_hsa049770.69024691
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68139562
78Glycerolipid metabolism_Homo sapiens_hsa005610.67519378
79* Metabolic pathways_Homo sapiens_hsa011000.65219409
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64856835
81Regulation of autophagy_Homo sapiens_hsa041400.64722861
82Lysine degradation_Homo sapiens_hsa003100.63168362
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61697813
84Oxidative phosphorylation_Homo sapiens_hsa001900.57520457
85Ribosome_Homo sapiens_hsa030100.51953467
86Caffeine metabolism_Homo sapiens_hsa002320.49303271
87N-Glycan biosynthesis_Homo sapiens_hsa005100.48716946
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47137702
89Collecting duct acid secretion_Homo sapiens_hsa049660.46726161
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44718795
91p53 signaling pathway_Homo sapiens_hsa041150.44599340
92Axon guidance_Homo sapiens_hsa043600.42530572
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.42480259
94Oocyte meiosis_Homo sapiens_hsa041140.41121126
95Parkinsons disease_Homo sapiens_hsa050120.40205667
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40149687
97Fructose and mannose metabolism_Homo sapiens_hsa000510.38670864
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38418548
99Phototransduction_Homo sapiens_hsa047440.37547102
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36797302
101Basal transcription factors_Homo sapiens_hsa030220.35229041
102Basal cell carcinoma_Homo sapiens_hsa052170.34986971
103Starch and sucrose metabolism_Homo sapiens_hsa005000.34482218
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.33275609
105RNA polymerase_Homo sapiens_hsa030200.33011917
106Prion diseases_Homo sapiens_hsa050200.31985051
107Hedgehog signaling pathway_Homo sapiens_hsa043400.29879812
108Wnt signaling pathway_Homo sapiens_hsa043100.29823091
109Adherens junction_Homo sapiens_hsa045200.29751136
110Ovarian steroidogenesis_Homo sapiens_hsa049130.27591650
111Huntingtons disease_Homo sapiens_hsa050160.27173153
112Vibrio cholerae infection_Homo sapiens_hsa051100.23886829
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23529977
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21594834
115Cocaine addiction_Homo sapiens_hsa050300.21322321
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20245653
117Serotonergic synapse_Homo sapiens_hsa047260.19357252
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19078462
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18606806
120Glucagon signaling pathway_Homo sapiens_hsa049220.17912751
121Dopaminergic synapse_Homo sapiens_hsa047280.17304815
122Alcoholism_Homo sapiens_hsa050340.17005472
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.16971566
124Alzheimers disease_Homo sapiens_hsa050100.16716769
125AMPK signaling pathway_Homo sapiens_hsa041520.15440624
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14660651
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14622035
128Tight junction_Homo sapiens_hsa045300.14529009
129Nicotine addiction_Homo sapiens_hsa050330.13403345
130RNA transport_Homo sapiens_hsa030130.12370465
131Hippo signaling pathway_Homo sapiens_hsa043900.07390271
132Sphingolipid metabolism_Homo sapiens_hsa006000.07030327
133Dorso-ventral axis formation_Homo sapiens_hsa043200.06676245
134Amphetamine addiction_Homo sapiens_hsa050310.06264174

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