FDPSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.82188978
2DNA deamination (GO:0045006)6.42048706
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.49917451
4ATP synthesis coupled proton transport (GO:0015986)5.43189914
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.43189914
6water-soluble vitamin biosynthetic process (GO:0042364)5.30945623
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16757430
8terpenoid biosynthetic process (GO:0016114)5.05505722
9chaperone-mediated protein transport (GO:0072321)4.90260286
10cytidine metabolic process (GO:0046087)4.70386150
11cytidine catabolic process (GO:0006216)4.70386150
12cytidine deamination (GO:0009972)4.70386150
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.44542892
14protein complex biogenesis (GO:0070271)4.32339626
15proteasome assembly (GO:0043248)4.20154023
16respiratory electron transport chain (GO:0022904)4.17224378
17electron transport chain (GO:0022900)4.12985502
18mitochondrial respiratory chain complex assembly (GO:0033108)4.04689625
19behavioral response to nicotine (GO:0035095)3.85792881
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.78484106
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.74150403
22NADH dehydrogenase complex assembly (GO:0010257)3.74150403
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74150403
24GTP biosynthetic process (GO:0006183)3.71996898
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57749092
26cytochrome complex assembly (GO:0017004)3.55834690
27regulation of cellular amino acid metabolic process (GO:0006521)3.53221685
28ribosomal small subunit assembly (GO:0000028)3.51364769
29hydrogen ion transmembrane transport (GO:1902600)3.50892890
30regulation of regulatory T cell differentiation (GO:0045589)3.45561390
31regulation of chronic inflammatory response (GO:0002676)3.40762777
32sequestering of actin monomers (GO:0042989)3.38890549
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37736560
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37736560
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34146794
36negative regulation of systemic arterial blood pressure (GO:0003085)3.32413226
37protein peptidyl-prolyl isomerization (GO:0000413)3.30913398
38respiratory chain complex IV assembly (GO:0008535)3.29868680
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25294284
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25294284
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25294284
42regulation of interleukin-12 biosynthetic process (GO:0045075)3.24775251
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22866991
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22866991
45proton transport (GO:0015992)3.22316195
46negative regulation of calcium ion transport into cytosol (GO:0010523)3.19857516
47UTP biosynthetic process (GO:0006228)3.18306742
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.18172947
49hydrogen transport (GO:0006818)3.16852155
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16656213
51regulation of mitochondrial translation (GO:0070129)3.14432029
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13185041
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10944159
54energy homeostasis (GO:0097009)3.08202872
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06950820
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.06950820
57protein-cofactor linkage (GO:0018065)3.06069153
58maturation of SSU-rRNA (GO:0030490)3.04473302
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.04370576
60cellular response to interleukin-15 (GO:0071350)3.03919633
61negative regulation of mast cell activation (GO:0033004)3.02312302
62angiogenesis involved in wound healing (GO:0060055)3.00500701
63ATP biosynthetic process (GO:0006754)2.99180207
64regulation of isotype switching to IgG isotypes (GO:0048302)2.98963534
65platelet dense granule organization (GO:0060155)2.95862729
66replication fork processing (GO:0031297)2.94831043
67signal peptide processing (GO:0006465)2.88950641
68negative regulation of ligase activity (GO:0051352)2.88852291
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88852291
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88203292
71termination of RNA polymerase III transcription (GO:0006386)2.86099466
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.86099466
73adaptation of signaling pathway (GO:0023058)2.84529560
74isoprenoid biosynthetic process (GO:0008299)2.82533886
75positive regulation of cell fate commitment (GO:0010455)2.82313855
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81355813
77intracellular protein transmembrane import (GO:0044743)2.80361917
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76238341
79UTP metabolic process (GO:0046051)2.75460437
80base-excision repair, AP site formation (GO:0006285)2.74457075
81ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66996525
82response to redox state (GO:0051775)2.66185480
83positive regulation of cell cycle arrest (GO:0071158)2.63408484
84mast cell activation (GO:0045576)2.61451718
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.61220473
86DNA strand renaturation (GO:0000733)2.61200285
87positive regulation of defense response to virus by host (GO:0002230)2.60424574
88ubiquinone biosynthetic process (GO:0006744)2.60334217
89indole-containing compound catabolic process (GO:0042436)2.58449052
90indolalkylamine catabolic process (GO:0046218)2.58449052
91tryptophan catabolic process (GO:0006569)2.58449052
92positive regulation of tolerance induction (GO:0002645)2.58235516
93kynurenine metabolic process (GO:0070189)2.56493031
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55567125
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54728322
96dopamine transport (GO:0015872)2.54496985
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54196997
98head development (GO:0060322)2.53865351
99positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.53606520
100resolution of meiotic recombination intermediates (GO:0000712)2.52907236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.58731630
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.99603237
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82263316
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69629301
5VDR_22108803_ChIP-Seq_LS180_Human3.34870673
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02504073
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93716817
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.85063411
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81959594
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80466259
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78628929
12ZNF274_21170338_ChIP-Seq_K562_Hela2.68685289
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67717451
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.55939543
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45514591
16VDR_23849224_ChIP-Seq_CD4+_Human2.44373923
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11426524
18ELK1_19687146_ChIP-ChIP_HELA_Human2.05098403
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03999309
20FOXP3_21729870_ChIP-Seq_TREG_Human1.99801365
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88574177
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.83087436
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74552971
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70414590
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.64632189
26EWS_26573619_Chip-Seq_HEK293_Human1.62735516
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.60112025
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58190729
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55581614
30TP53_22573176_ChIP-Seq_HFKS_Human1.52110810
31IRF1_19129219_ChIP-ChIP_H3396_Human1.51691687
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.41463036
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39643103
34NCOR_22424771_ChIP-Seq_293T_Human1.38353380
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.37637821
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33188109
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33130727
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32868896
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31627460
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28948925
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28846594
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.28114031
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28013035
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.28013035
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26983830
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26295868
47MYC_18940864_ChIP-ChIP_HL60_Human1.22943800
48TTF2_22483619_ChIP-Seq_HELA_Human1.20619444
49ER_23166858_ChIP-Seq_MCF-7_Human1.18788807
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.17504756
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.15288747
52GABP_19822575_ChIP-Seq_HepG2_Human1.14967051
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14852779
54AR_20517297_ChIP-Seq_VCAP_Human1.14387512
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13981488
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11842901
57TAF2_19829295_ChIP-Seq_ESCs_Human1.11758058
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11102304
59SOX2_19829295_ChIP-Seq_ESCs_Human1.10624381
60NANOG_19829295_ChIP-Seq_ESCs_Human1.10624381
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10010326
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09106534
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08545827
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08519524
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08184450
66DCP1A_22483619_ChIP-Seq_HELA_Human1.07853060
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02461556
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01919135
69AR_21572438_ChIP-Seq_LNCaP_Human1.01492968
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01371321
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00798941
72P300_19829295_ChIP-Seq_ESCs_Human1.00587176
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99634005
74MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99539795
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99262052
76IGF1R_20145208_ChIP-Seq_DFB_Human0.99097280
77MYC_19829295_ChIP-Seq_ESCs_Human0.98377267
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98193406
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97987762
80FUS_26573619_Chip-Seq_HEK293_Human0.97109741
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96285444
82HOXB7_26014856_ChIP-Seq_BT474_Human0.91776310
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91050471
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90578889
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90348278
86CBP_20019798_ChIP-Seq_JUKART_Human0.90348278
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90007548
88NANOG_20526341_ChIP-Seq_ESCs_Human0.89401914
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87540132
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87359900
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87333560
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86978566
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86261386
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86191439
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85565596
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85071584
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84960459
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.84478247
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84172066
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83990017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002277_abnormal_respiratory_mucosa3.22252348
2MP0004147_increased_porphyrin_level3.11903948
3MP0008872_abnormal_physiological_respon2.93707627
4MP0002102_abnormal_ear_morphology2.91748975
5MP0003011_delayed_dark_adaptation2.75054004
6MP0003183_abnormal_peptide_metabolism2.61652252
7MP0006054_spinal_hemorrhage2.48581007
8MP0001873_stomach_inflammation2.43842827
9MP0004742_abnormal_vestibular_system2.34614399
10MP0001485_abnormal_pinna_reflex2.27069490
11MP0005671_abnormal_response_to2.26985427
12MP0008875_abnormal_xenobiotic_pharmacok2.03156336
13MP0002876_abnormal_thyroid_physiology1.96287278
14MP0003878_abnormal_ear_physiology1.94393068
15MP0005377_hearing/vestibular/ear_phenot1.94393068
16MP0002638_abnormal_pupillary_reflex1.89385742
17MP0004885_abnormal_endolymph1.84849937
18MP0009785_altered_susceptibility_to1.83116429
19MP0003195_calcinosis1.77011168
20MP0003283_abnormal_digestive_organ1.75753929
21MP0000685_abnormal_immune_system1.75545721
22MP0005167_abnormal_blood-brain_barrier1.72429906
23MP0004145_abnormal_muscle_electrophysio1.66244205
24MP0005257_abnormal_intraocular_pressure1.65541841
25MP0008877_abnormal_DNA_methylation1.60168145
26MP0006292_abnormal_olfactory_placode1.58222132
27MP0001905_abnormal_dopamine_level1.54315706
28MP0003866_abnormal_defecation1.52777760
29MP0001835_abnormal_antigen_presentation1.51140373
30MP0002138_abnormal_hepatobiliary_system1.50645805
31MP0001968_abnormal_touch/_nociception1.48516080
32MP0002736_abnormal_nociception_after1.48058551
33MP0001293_anophthalmia1.46706757
34MP0005551_abnormal_eye_electrophysiolog1.46366753
35MP0003718_maternal_effect1.46327741
36MP0009745_abnormal_behavioral_response1.41749785
37MP0004142_abnormal_muscle_tone1.41513321
38MP0001800_abnormal_humoral_immune1.41049602
39MP0002735_abnormal_chemical_nociception1.40030748
40MP0005645_abnormal_hypothalamus_physiol1.36094679
41MP0001529_abnormal_vocalization1.34249790
42MP0005387_immune_system_phenotype1.32974363
43MP0001790_abnormal_immune_system1.32974363
44MP0003786_premature_aging1.27011581
45MP0002163_abnormal_gland_morphology1.26995071
46MP0000569_abnormal_digit_pigmentation1.26935529
47MP0001486_abnormal_startle_reflex1.25292813
48MP0005646_abnormal_pituitary_gland1.23881252
49MP0006036_abnormal_mitochondrial_physio1.21960335
50MP0004215_abnormal_myocardial_fiber1.19680395
51MP0001502_abnormal_circadian_rhythm1.19215657
52MP0001919_abnormal_reproductive_system1.11219166
53MP0001970_abnormal_pain_threshold1.10416507
54MP0002148_abnormal_hypersensitivity_rea1.10025462
55MP0003567_abnormal_fetal_cardiomyocyte1.07187141
56MP0002693_abnormal_pancreas_physiology1.05891954
57MP0002160_abnormal_reproductive_system1.05758173
58MP0005389_reproductive_system_phenotype1.02358619
59MP0003693_abnormal_embryo_hatching1.02076856
60MP0001440_abnormal_grooming_behavior1.00897402
61MP0003186_abnormal_redox_activity0.99354210
62MP0002272_abnormal_nervous_system0.99028422
63MP0001986_abnormal_taste_sensitivity0.98032413
64MP0003787_abnormal_imprinting0.96454609
65MP0002733_abnormal_thermal_nociception0.95921098
66MP0003122_maternal_imprinting0.95890180
67MP0006276_abnormal_autonomic_nervous0.92857064
68MP0002234_abnormal_pharynx_morphology0.92673001
69MP0005448_abnormal_energy_balance0.92310387
70MP0003880_abnormal_central_pattern0.91276593
71MP0005636_abnormal_mineral_homeostasis0.91074615
72MP0003638_abnormal_response/metabolism_0.89096281
73MP0005085_abnormal_gallbladder_physiolo0.87392593
74MP0004043_abnormal_pH_regulation0.86784450
75MP0001984_abnormal_olfaction0.83835122
76MP0005000_abnormal_immune_tolerance0.82746463
77MP0010155_abnormal_intestine_physiology0.81975068
78MP0005084_abnormal_gallbladder_morpholo0.81636620
79MP0008775_abnormal_heart_ventricle0.81174410
80MP0002723_abnormal_immune_serum0.81050716
81MP0006035_abnormal_mitochondrial_morpho0.79022235
82MP0001663_abnormal_digestive_system0.78773729
83MP0001501_abnormal_sleep_pattern0.75229496
84MP0001765_abnormal_ion_homeostasis0.74197356
85MP0002420_abnormal_adaptive_immunity0.73465731
86MP0003315_abnormal_perineum_morphology0.72958498
87MP0002064_seizures0.72127761
88MP0001819_abnormal_immune_cell0.71764059
89MP0005310_abnormal_salivary_gland0.70566925
90MP0005025_abnormal_response_to0.70539563
91MP0000613_abnormal_salivary_gland0.70395928
92MP0005670_abnormal_white_adipose0.68759249
93MP0001666_abnormal_nutrient_absorption0.67415606
94MP0001845_abnormal_inflammatory_respons0.66669376
95MP0003938_abnormal_ear_development0.66652294
96MP0000026_abnormal_inner_ear0.64610686
97MP0002063_abnormal_learning/memory/cond0.64588472
98MP0002837_dystrophic_cardiac_calcinosis0.64131998
99MP0008789_abnormal_olfactory_epithelium0.63919178
100MP0000372_irregular_coat_pigmentation0.62680440

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57398285
2Mitochondrial inheritance (HP:0001427)4.30469434
3Increased CSF lactate (HP:0002490)4.06051061
4Methylmalonic aciduria (HP:0012120)4.05793910
5Congenital stationary night blindness (HP:0007642)3.95858553
6Acute encephalopathy (HP:0006846)3.86985967
7Abnormal mitochondria in muscle tissue (HP:0008316)3.81376060
8Progressive macrocephaly (HP:0004481)3.75249529
9Hepatocellular necrosis (HP:0001404)3.74970622
103-Methylglutaconic aciduria (HP:0003535)3.46731945
11Methylmalonic acidemia (HP:0002912)3.45531825
12Increased hepatocellular lipid droplets (HP:0006565)3.40476220
13Hepatic necrosis (HP:0002605)3.23772045
14IgG deficiency (HP:0004315)3.17298359
15Agitation (HP:0000713)3.16598293
16Cerebral hypomyelination (HP:0006808)3.10467747
17Abnormality of the renal cortex (HP:0011035)3.09830011
18Lipid accumulation in hepatocytes (HP:0006561)3.05678859
19Decreased electroretinogram (ERG) amplitude (HP:0000654)3.03960418
20Abnormality of B cell number (HP:0010975)2.94888767
21Optic disc pallor (HP:0000543)2.86790623
22Molar tooth sign on MRI (HP:0002419)2.85513133
23Abnormality of midbrain morphology (HP:0002418)2.85513133
24Pancreatic cysts (HP:0001737)2.80135696
25Delayed CNS myelination (HP:0002188)2.79175691
26Increased IgM level (HP:0003496)2.75007534
27Pendular nystagmus (HP:0012043)2.71183981
28Stomach cancer (HP:0012126)2.70097995
29Renal Fanconi syndrome (HP:0001994)2.66867497
30Cerebral edema (HP:0002181)2.55319666
31Oligodactyly (hands) (HP:0001180)2.55083324
32Autoimmune hemolytic anemia (HP:0001890)2.52478453
33Increased serum lactate (HP:0002151)2.51750030
34Congenital, generalized hypertrichosis (HP:0004540)2.49118089
35Colon cancer (HP:0003003)2.48159150
36Abolished electroretinogram (ERG) (HP:0000550)2.48001532
37Leukodystrophy (HP:0002415)2.43233455
38Renal cortical cysts (HP:0000803)2.42677389
39Elevated erythrocyte sedimentation rate (HP:0003565)2.41636415
40Papilledema (HP:0001085)2.40063280
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39769850
42Respiratory failure (HP:0002878)2.39087443
43CNS hypomyelination (HP:0003429)2.34637502
44Pancreatic fibrosis (HP:0100732)2.33663415
45Lactic acidosis (HP:0003128)2.32766960
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31820501
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31820501
48Exertional dyspnea (HP:0002875)2.29605344
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.22754355
50Abnormality of the renal medulla (HP:0100957)2.20999273
51Oral leukoplakia (HP:0002745)2.20168561
52True hermaphroditism (HP:0010459)2.17854186
53Nephronophthisis (HP:0000090)2.16514297
54Abnormality of the pons (HP:0007361)2.14909507
55Sclerocornea (HP:0000647)2.10204385
56Abnormality of T cell number (HP:0011839)2.09316737
57Hypoproteinemia (HP:0003075)2.07516007
58Aplastic anemia (HP:0001915)2.06892047
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05748916
60Broad alveolar ridges (HP:0000187)2.04818598
61Lethargy (HP:0001254)2.04333756
62Hypoalbuminemia (HP:0003073)2.02203091
63Abnormal albumin level (HP:0012116)2.02203091
64Pancytopenia (HP:0001876)2.00810313
65Increased intramyocellular lipid droplets (HP:0012240)2.00297174
66Abnormality of T cells (HP:0002843)1.99944624
67Volvulus (HP:0002580)1.99795362
68Cellular immunodeficiency (HP:0005374)1.98310765
69Progressive inability to walk (HP:0002505)1.96558632
70Stomatitis (HP:0010280)1.92606753
71Aplasia/Hypoplasia of the spleen (HP:0010451)1.91019350
72Adactyly (HP:0009776)1.90920546
73Stenosis of the external auditory canal (HP:0000402)1.90653481
74Increased serum pyruvate (HP:0003542)1.89752910
75Medial flaring of the eyebrow (HP:0010747)1.88677360
76Abnormality of T cell physiology (HP:0011840)1.87653631
77Abnormality of the alveolar ridges (HP:0006477)1.87419870
78Hypoplasia of the pons (HP:0012110)1.87085086
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86239031
80Type II lissencephaly (HP:0007260)1.86032267
81Abnormal respiratory epithelium morphology (HP:0012253)1.85929708
82Abnormal respiratory motile cilium morphology (HP:0005938)1.85929708
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.85306687
84Absent/shortened dynein arms (HP:0200106)1.85306687
85Inability to walk (HP:0002540)1.83734739
86Abnormality of renal resorption (HP:0011038)1.82970318
87Abnormal rod and cone electroretinograms (HP:0008323)1.81989192
88Reticulocytopenia (HP:0001896)1.81982990
89Asplenia (HP:0001746)1.81829817
90Abnormality of placental membranes (HP:0011409)1.81760509
91Amniotic constriction ring (HP:0009775)1.81760509
92Dicarboxylic aciduria (HP:0003215)1.80743858
93Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80743858
94Parakeratosis (HP:0001036)1.80263603
95Autoimmune thrombocytopenia (HP:0001973)1.78012017
96CNS demyelination (HP:0007305)1.77550231
97X-linked dominant inheritance (HP:0001423)1.77511001
98Constricted visual fields (HP:0001133)1.76008796
99Hyperglycinemia (HP:0002154)1.73946333
100Exercise intolerance (HP:0003546)1.70018133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.09134668
2VRK23.86162123
3TIE13.68872564
4PINK13.40453514
5TLK12.84364235
6GRK12.34549916
7NME12.19595223
8WNK42.18769113
9TAF12.18286569
10NUAK12.16966487
11ZAK2.11839968
12SIK22.00558736
13TRIM281.99477448
14TSSK61.99294407
15WNK31.94701986
16PASK1.89054913
17PDK21.76776106
18VRK11.70040735
19EIF2AK31.69321731
20BCR1.57597546
21MST41.52347655
22TEC1.52048256
23ADRBK21.47481814
24MAPKAPK31.42413173
25BUB11.40130774
26DYRK21.37726484
27MAP2K61.35915589
28BCKDK1.30699202
29PLK21.17464509
30FRK1.17430991
31MAP4K11.17155213
32CAMKK21.13832201
33TNIK1.13134680
34OXSR11.12228962
35KDR1.09380240
36MAP3K121.04673166
37STK391.01798659
38DAPK11.01542693
39FES1.01057169
40EIF2AK20.99414938
41PHKG20.99316522
42PHKG10.99316522
43ITK0.95073028
44PLK30.94278443
45STK160.89800084
46KIT0.89466334
47PBK0.86301813
48DAPK20.84047981
49CSNK1G30.83580745
50GRK50.82899802
51CDK190.81829151
52MAP4K20.81197712
53PRKCG0.79728243
54NEK10.78898764
55MAP2K70.77598907
56SYK0.77313731
57CSNK1A1L0.76515568
58SIK30.75716111
59NME20.75422438
60CAMKK10.72106447
61INSRR0.69336642
62CSNK1G20.68375367
63CASK0.65862392
64EIF2AK10.65616196
65CSNK1G10.65012074
66CDK80.64243224
67PIK3CG0.62978823
68SRPK10.60468465
69BMPR1B0.57047972
70PRKCQ0.56967370
71AURKA0.53349834
72PRKCH0.48493648
73IGF1R0.47468068
74EPHB20.44869461
75ADRBK10.43209238
76MINK10.42574715
77IRAK40.41831187
78LIMK10.39872728
79DAPK30.39191532
80LCK0.37795845
81MYLK0.37641593
82ALK0.37095186
83PRKCE0.36564499
84MAP3K110.36476816
85PRKCD0.35889149
86PRKCA0.34659364
87CAMK10.32505737
88GRK70.32112162
89PRKACA0.31365381
90CSNK2A10.31232943
91IKBKB0.31013692
92NEK20.30007843
93EPHA40.29630858
94CAMK2A0.29424356
95ZAP700.29235241
96OBSCN0.28668626
97TAOK10.28293860
98MAP3K40.28201777
99PIK3CA0.28085382
100CSNK2A20.26334902

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.66740404
2Oxidative phosphorylation_Homo sapiens_hsa001903.87972682
3Parkinsons disease_Homo sapiens_hsa050123.29117354
4Protein export_Homo sapiens_hsa030602.44580430
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38713719
6Alzheimers disease_Homo sapiens_hsa050102.35135182
7Ribosome_Homo sapiens_hsa030102.26222179
8Primary immunodeficiency_Homo sapiens_hsa053402.25219851
9Huntingtons disease_Homo sapiens_hsa050162.16160616
10RNA polymerase_Homo sapiens_hsa030202.11715965
11Cardiac muscle contraction_Homo sapiens_hsa042602.04665833
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03182933
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91316498
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85351477
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76731307
16Graft-versus-host disease_Homo sapiens_hsa053321.68302515
17Basal transcription factors_Homo sapiens_hsa030221.63960579
18Type I diabetes mellitus_Homo sapiens_hsa049401.62500541
19Antigen processing and presentation_Homo sapiens_hsa046121.61084889
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54543645
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53970966
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47878237
23Steroid biosynthesis_Homo sapiens_hsa001001.47691513
24Homologous recombination_Homo sapiens_hsa034401.41458081
25Autoimmune thyroid disease_Homo sapiens_hsa053201.40090871
26Asthma_Homo sapiens_hsa053101.32669997
27Propanoate metabolism_Homo sapiens_hsa006401.30964415
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29676357
29Allograft rejection_Homo sapiens_hsa053301.28032762
30Phototransduction_Homo sapiens_hsa047441.26559130
31Nitrogen metabolism_Homo sapiens_hsa009101.26342968
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.25778604
33Tryptophan metabolism_Homo sapiens_hsa003801.20708643
34Caffeine metabolism_Homo sapiens_hsa002321.20693820
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15634190
36Peroxisome_Homo sapiens_hsa041461.13442092
37Pyrimidine metabolism_Homo sapiens_hsa002401.10979981
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10788816
39RNA degradation_Homo sapiens_hsa030181.10486726
40Nucleotide excision repair_Homo sapiens_hsa034201.09915321
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09453230
42Hematopoietic cell lineage_Homo sapiens_hsa046401.01720230
43Butanoate metabolism_Homo sapiens_hsa006501.01417862
44Sulfur metabolism_Homo sapiens_hsa009201.00003936
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97182459
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96244718
47Rheumatoid arthritis_Homo sapiens_hsa053230.95704102
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94579124
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.94012887
50Renin-angiotensin system_Homo sapiens_hsa046140.93958628
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.92741883
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86548076
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86361089
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.85373684
55Linoleic acid metabolism_Homo sapiens_hsa005910.83666309
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83102785
57Pyruvate metabolism_Homo sapiens_hsa006200.81404516
58DNA replication_Homo sapiens_hsa030300.80777028
59Mismatch repair_Homo sapiens_hsa034300.80309283
60beta-Alanine metabolism_Homo sapiens_hsa004100.78554625
61Purine metabolism_Homo sapiens_hsa002300.78500386
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78297152
63Base excision repair_Homo sapiens_hsa034100.75763507
64Regulation of autophagy_Homo sapiens_hsa041400.72713296
65Fanconi anemia pathway_Homo sapiens_hsa034600.71627574
66Chemical carcinogenesis_Homo sapiens_hsa052040.71256774
67RNA transport_Homo sapiens_hsa030130.70776395
68Metabolic pathways_Homo sapiens_hsa011000.69774662
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69064489
70Glutathione metabolism_Homo sapiens_hsa004800.66249345
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.65593667
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64716611
73Spliceosome_Homo sapiens_hsa030400.61900325
74Fatty acid elongation_Homo sapiens_hsa000620.59722981
75Fatty acid degradation_Homo sapiens_hsa000710.59113106
76T cell receptor signaling pathway_Homo sapiens_hsa046600.55413772
77Fat digestion and absorption_Homo sapiens_hsa049750.55156781
78Fatty acid metabolism_Homo sapiens_hsa012120.54946350
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53939904
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53176219
81Folate biosynthesis_Homo sapiens_hsa007900.50887738
82One carbon pool by folate_Homo sapiens_hsa006700.50802412
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47475029
84Retinol metabolism_Homo sapiens_hsa008300.47261148
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47157201
86Salivary secretion_Homo sapiens_hsa049700.46760332
87Collecting duct acid secretion_Homo sapiens_hsa049660.46476326
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.45067982
89Systemic lupus erythematosus_Homo sapiens_hsa053220.43136533
90Arginine and proline metabolism_Homo sapiens_hsa003300.42831279
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38741187
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38118956
93Morphine addiction_Homo sapiens_hsa050320.37639129
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37068212
95Ether lipid metabolism_Homo sapiens_hsa005650.36925346
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35672645
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35379516
98GABAergic synapse_Homo sapiens_hsa047270.32899582
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31990942
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31834819

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