ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of growth hormone secretion (GO:0060124)	5.26089417
2	peptidyl-histidine modification (GO:0018202)	4.79977977
3	adenosine metabolic process (GO:0046085)	4.69508601
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.48551066
5	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.48551066
6	cellular response to interferon-beta (GO:0035458)	4.14378799
7	preassembly of GPI anchor in ER membrane (GO:0016254)	4.11873960
8	adaptation of signaling pathway (GO:0023058)	4.06853015
9	determination of adult lifespan (GO:0008340)	3.91648102
10	growth hormone secretion (GO:0030252)	3.80848733
11	coenzyme catabolic process (GO:0009109)	3.76461300
12	piRNA metabolic process (GO:0034587)	3.67471000
13	amine catabolic process (GO:0009310)	3.64212227
14	cellular biogenic amine catabolic process (GO:0042402)	3.64212227
15	phenylpropanoid metabolic process (GO:0009698)	3.63122153
16	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.53996962
17	regulation of growth hormone secretion (GO:0060123)	3.52473171
18	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.44919802
19	nephron tubule morphogenesis (GO:0072078)	3.43467446
20	nephron epithelium morphogenesis (GO:0072088)	3.43467446
21	C-terminal protein amino acid modification (GO:0018410)	3.41520913
22	DNA double-strand break processing (GO:0000729)	3.39385045
23	C-terminal protein lipidation (GO:0006501)	3.31794465
24	DNA deamination (GO:0045006)	3.30131556
25	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.28622145
26	xenobiotic catabolic process (GO:0042178)	3.26637871
27	renal absorption (GO:0070293)	3.25425912
28	protein complex biogenesis (GO:0070271)	3.23990271
29	proteasome assembly (GO:0043248)	3.22880759
30	signal peptide processing (GO:0006465)	3.22676099
31	regulation of glucokinase activity (GO:0033131)	3.22389977
32	regulation of hexokinase activity (GO:1903299)	3.22389977
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20887821
34	prenylation (GO:0097354)	3.19075880
35	protein prenylation (GO:0018342)	3.19075880
36	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.14169404
37	tryptophan catabolic process (GO:0006569)	3.11843320
38	indole-containing compound catabolic process (GO:0042436)	3.11843320
39	indolalkylamine catabolic process (GO:0046218)	3.11843320
40	intraciliary transport (GO:0042073)	3.09977564
41	neurotransmitter uptake (GO:0001504)	3.06102034
42	mannosylation (GO:0097502)	3.05982518
43	lactate metabolic process (GO:0006089)	3.04407368
44	rRNA modification (GO:0000154)	3.04174821
45	resolution of meiotic recombination intermediates (GO:0000712)	3.03407634
46	rRNA methylation (GO:0031167)	3.03372831
47	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.02138774
48	platelet dense granule organization (GO:0060155)	3.00347851
49	mismatch repair (GO:0006298)	3.00077603
50	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.99938703
51	regulation of cellular amino acid metabolic process (GO:0006521)	2.97951934
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.97199392
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.97199392
54	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.97199392
55	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.94947355
56	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.94947355
57	water-soluble vitamin biosynthetic process (GO:0042364)	2.94862466
58	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.93397719
59	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.93364520
60	L-methionine salvage (GO:0071267)	2.92590657
61	L-methionine biosynthetic process (GO:0071265)	2.92590657
62	amino acid salvage (GO:0043102)	2.92590657
63	natural killer cell differentiation (GO:0001779)	2.92073789
64	kynurenine metabolic process (GO:0070189)	2.91292541
65	negative regulation of telomere maintenance (GO:0032205)	2.90679127
66	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.88217441
67	ribonucleoprotein complex disassembly (GO:0032988)	2.86559275
68	response to interferon-beta (GO:0035456)	2.85454798
69	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.82821017
70	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.82615164
71	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.82615164
72	coenzyme A metabolic process (GO:0015936)	2.81754231
73	nucleotide transmembrane transport (GO:1901679)	2.79512677
74	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79169648
75	NADH dehydrogenase complex assembly (GO:0010257)	2.79169648
76	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79169648
77	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.78703253
78	cellular ketone body metabolic process (GO:0046950)	2.77501735
79	respiratory chain complex IV assembly (GO:0008535)	2.76257375
80	axoneme assembly (GO:0035082)	2.75755967
81	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.72836627
82	regulation of RIG-I signaling pathway (GO:0039535)	2.72423708
83	termination of RNA polymerase I transcription (GO:0006363)	2.66474431
84	GPI anchor biosynthetic process (GO:0006506)	2.65673809
85	positive regulation of B cell differentiation (GO:0045579)	2.61778477
86	indolalkylamine metabolic process (GO:0006586)	2.61741631
87	activation of adenylate cyclase activity (GO:0007190)	2.60818662
88	succinate metabolic process (GO:0006105)	2.60565588
89	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.59624870
90	cytochrome complex assembly (GO:0017004)	2.59237921
91	ovulation cycle (GO:0042698)	2.58791270
92	cullin deneddylation (GO:0010388)	2.56792712
93	tryptophan metabolic process (GO:0006568)	2.55119134
94	poly(A)+ mRNA export from nucleus (GO:0016973)	2.54261230
95	L-glutamate transport (GO:0015813)	2.53622117
96	phosphatidylglycerol biosynthetic process (GO:0006655)	2.52562870
97	purine nucleobase biosynthetic process (GO:0009113)	2.51988299
98	ketone body metabolic process (GO:1902224)	2.50856219
99	protein deneddylation (GO:0000338)	2.50103135
100	negative regulation of multicellular organism growth (GO:0040015)	2.50009875

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10144837
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.34071494
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16438573
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90605556
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66003026
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.54248180
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53528422
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41204189
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.23795159
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.21775630
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.19811425
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14714717
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.05728583
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.00564536
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99671301
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99311294
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.96476060
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95623045
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93373997
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86969463
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86272281
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.83251975
23	GATA1_22025678_ChIP-Seq_K562_Human	1.76996406
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.73479570
25	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.70901608
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69720055
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66728965
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.63355056
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60309248
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.59724122
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.58785013
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57266260
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55125080
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55045498
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54648212
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53528266
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53320359
38	FUS_26573619_Chip-Seq_HEK293_Human	1.50089079
39	EWS_26573619_Chip-Seq_HEK293_Human	1.48952889
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.46034589
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.45718949
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.41197486
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38987724
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37113745
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37113745
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.36761077
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34935838
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33929064
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.33929064
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33599809
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32498322
52	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.31630608
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.31184362
54	GATA3_26560356_Chip-Seq_TH2_Human	1.29635020
55	P300_19829295_ChIP-Seq_ESCs_Human	1.29568969
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29065602
57	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.27005290
58	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23457601
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21729560
60	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.19911404
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19865958
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19685221
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19353895
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16416190
65	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14845556
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12816926
67	E2F7_22180533_ChIP-Seq_HELA_Human	1.12510888
68	PHF8_20622853_ChIP-Seq_HELA_Human	1.11276646
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11115062
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11115062
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10768732
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10343657
73	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10038779
74	AR_20517297_ChIP-Seq_VCAP_Human	1.08445085
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08143552
76	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.06416214
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06220431
78	P300_18555785_Chip-Seq_ESCs_Mouse	1.05689108
79	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.04702694
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04676461
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03047141
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02348899
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02043444
84	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.01656109
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01244023
86	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01150030
87	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.00926312
88	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.00480757
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00211217
90	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99373996
91	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99015966
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98224250
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98000725
94	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.97244746
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96721895
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96590973
97	NCOR_22424771_ChIP-Seq_293T_Human	0.96352722
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96236172
99	GABP_19822575_ChIP-Seq_HepG2_Human	0.96002569
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95892210

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.22951410
2	MP0008057_abnormal_DNA_replication	3.10115588
3	MP0006035_abnormal_mitochondrial_morpho	3.01973280
4	MP0008877_abnormal_DNA_methylation	2.95653029
5	MP0002254_reproductive_system_inflammat	2.86364926
6	MP0002736_abnormal_nociception_after	2.77410052
7	MP0002638_abnormal_pupillary_reflex	2.59838110
8	MP0000015_abnormal_ear_pigmentation	2.47903053
9	MP0001984_abnormal_olfaction	2.44332104
10	MP0001529_abnormal_vocalization	2.30549317
11	MP0006036_abnormal_mitochondrial_physio	2.30405936
12	MP0006054_spinal_hemorrhage	2.29924872
13	MP0002909_abnormal_adrenal_gland	2.24378306
14	MP0004043_abnormal_pH_regulation	2.13451795
15	MP0006276_abnormal_autonomic_nervous	2.13141594
16	MP0000372_irregular_coat_pigmentation	2.08666350
17	MP0001501_abnormal_sleep_pattern	2.08450653
18	MP0003880_abnormal_central_pattern	2.08280142
19	MP0001835_abnormal_antigen_presentation	2.05402309
20	MP0005266_abnormal_metabolism	1.97783999
21	MP0005075_abnormal_melanosome_morpholog	1.91704070
22	MP0008058_abnormal_DNA_repair	1.91109770
23	MP0005671_abnormal_response_to	1.88171780
24	MP0005551_abnormal_eye_electrophysiolog	1.84603893
25	MP0002090_abnormal_vision	1.80904357
26	MP0003806_abnormal_nucleotide_metabolis	1.75347632
27	MP0008961_abnormal_basal_metabolism	1.68565635
28	MP0000358_abnormal_cell_content/	1.67661125
29	MP0008875_abnormal_xenobiotic_pharmacok	1.64953858
30	MP0008872_abnormal_physiological_respon	1.61579646
31	MP0001968_abnormal_touch/_nociception	1.60066860
32	MP0003136_yellow_coat_color	1.55920452
33	MP0002132_abnormal_respiratory_system	1.54126927
34	MP0005645_abnormal_hypothalamus_physiol	1.51779970
35	MP0006072_abnormal_retinal_apoptosis	1.50374119
36	MP0010094_abnormal_chromosome_stability	1.46732770
37	MP0003693_abnormal_embryo_hatching	1.46197855
38	MP0005410_abnormal_fertilization	1.43327117
39	MP0001905_abnormal_dopamine_level	1.39001031
40	MP0002166_altered_tumor_susceptibility	1.33883377
41	MP0005253_abnormal_eye_physiology	1.31922627
42	MP0002095_abnormal_skin_pigmentation	1.31252983
43	MP0003172_abnormal_lysosome_physiology	1.30041214
44	MP0004215_abnormal_myocardial_fiber	1.29951972
45	MP0003718_maternal_effect	1.29063068
46	MP0005058_abnormal_lysosome_morphology	1.26000547
47	MP0005365_abnormal_bile_salt	1.24433828
48	MP0003195_calcinosis	1.24052308
49	MP0003786_premature_aging	1.22244418
50	MP0010329_abnormal_lipoprotein_level	1.20294925
51	MP0000685_abnormal_immune_system	1.19979041
52	MP0003221_abnormal_cardiomyocyte_apopto	1.14415165
53	MP0005464_abnormal_platelet_physiology	1.13357292
54	MP0002138_abnormal_hepatobiliary_system	1.08611820
55	MP0009764_decreased_sensitivity_to	1.08287967
56	MP0001486_abnormal_startle_reflex	1.07105567
57	MP0001661_extended_life_span	1.06054052
58	MP0009697_abnormal_copulation	1.03418196
59	MP0002693_abnormal_pancreas_physiology	1.02047494
60	MP0004133_heterotaxia	1.01898111
61	MP0002876_abnormal_thyroid_physiology	0.99878896
62	MP0000647_abnormal_sebaceous_gland	0.99847640
63	MP0002163_abnormal_gland_morphology	0.99447592
64	MP0002332_abnormal_exercise_endurance	0.99148674
65	MP0005379_endocrine/exocrine_gland_phen	0.98722413
66	MP0003011_delayed_dark_adaptation	0.98052795
67	MP0001881_abnormal_mammary_gland	0.96603910
68	MP0008004_abnormal_stomach_pH	0.95198048
69	MP0002006_tumorigenesis	0.94090179
70	MP0003077_abnormal_cell_cycle	0.90126850
71	MP0002734_abnormal_mechanical_nocicepti	0.86718897
72	MP0001800_abnormal_humoral_immune	0.86328316
73	MP0005332_abnormal_amino_acid	0.85236628
74	MP0000230_abnormal_systemic_arterial	0.83334526
75	MP0003186_abnormal_redox_activity	0.82688531
76	MP0001929_abnormal_gametogenesis	0.80484997
77	MP0003698_abnormal_male_reproductive	0.79424549
78	MP0005376_homeostasis/metabolism_phenot	0.78053595
79	MP0009745_abnormal_behavioral_response	0.77557182
80	MP0009046_muscle_twitch	0.75543851
81	MP0002229_neurodegeneration	0.75271273
82	MP0002277_abnormal_respiratory_mucosa	0.75054863
83	MP0002723_abnormal_immune_serum	0.74987126
84	MP0001485_abnormal_pinna_reflex	0.70598966
85	MP0000427_abnormal_hair_cycle	0.70341762
86	MP0000639_abnormal_adrenal_gland	0.69839260
87	MP0005167_abnormal_blood-brain_barrier	0.69682755
88	MP0001293_anophthalmia	0.69521829
89	MP0002751_abnormal_autonomic_nervous	0.66183058
90	MP0000383_abnormal_hair_follicle	0.65933619
91	MP0005310_abnormal_salivary_gland	0.65508115
92	MP0001970_abnormal_pain_threshold	0.65251276
93	MP0004085_abnormal_heartbeat	0.64941319
94	MP0002069_abnormal_eating/drinking_beha	0.64442179
95	MP0008873_increased_physiological_sensi	0.64260934
96	MP0002272_abnormal_nervous_system	0.63691026
97	MP0000631_abnormal_neuroendocrine_gland	0.63328564
98	MP0002452_abnormal_antigen_presenting	0.63085737
99	MP0002210_abnormal_sex_determination	0.62423375
100	MP0003183_abnormal_peptide_metabolism	0.61687093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	5.76149965
2	Hyperalaninemia (HP:0003348)	5.76149965
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.76149965
4	Sensory axonal neuropathy (HP:0003390)	5.30973061
5	Progressive inability to walk (HP:0002505)	4.25176782
6	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.25429789
7	Hypoplasia of the fovea (HP:0007750)	3.25429789
8	Pancreatic cysts (HP:0001737)	3.14878267
9	True hermaphroditism (HP:0010459)	3.03760240
10	Pancreatic islet-cell hyperplasia (HP:0004510)	2.99878216
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.85715220
12	Lipid accumulation in hepatocytes (HP:0006561)	2.83436023
13	Prostate neoplasm (HP:0100787)	2.80498550
14	Abnormality of the fovea (HP:0000493)	2.78254486
15	Acute necrotizing encephalopathy (HP:0006965)	2.76788181
16	Facial diplegia (HP:0001349)	2.74379539
17	Large for gestational age (HP:0001520)	2.72656024
18	Mitochondrial inheritance (HP:0001427)	2.69795316
19	Abnormality of the prostate (HP:0008775)	2.68890622
20	Vacuolated lymphocytes (HP:0001922)	2.67634718
21	Abolished electroretinogram (ERG) (HP:0000550)	2.67220651
22	Increased CSF lactate (HP:0002490)	2.60585302
23	Pancreatic fibrosis (HP:0100732)	2.56864516
24	Abnormality of serum amino acid levels (HP:0003112)	2.51390963
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50910696
26	Hepatocellular necrosis (HP:0001404)	2.49192403
27	Inability to walk (HP:0002540)	2.45266557
28	Nephronophthisis (HP:0000090)	2.42742337
29	Chronic hepatic failure (HP:0100626)	2.42699138
30	Insulin-resistant diabetes mellitus (HP:0000831)	2.38301107
31	Methylmalonic acidemia (HP:0002912)	2.38280699
32	Severe visual impairment (HP:0001141)	2.36350223
33	Dyschromatopsia (HP:0007641)	2.33965977
34	Intestinal atresia (HP:0011100)	2.30681687
35	Cerebral edema (HP:0002181)	2.30077941
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.27706390
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.27706390
38	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.27635070
39	Acute encephalopathy (HP:0006846)	2.26716395
40	Progressive macrocephaly (HP:0004481)	2.25891266
41	Spastic paraparesis (HP:0002313)	2.24518307
42	Hemiparesis (HP:0001269)	2.22201479
43	Decreased central vision (HP:0007663)	2.17050712
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.16551195
45	Prominent metopic ridge (HP:0005487)	2.14786703
46	Distal arthrogryposis (HP:0005684)	2.14666989
47	Optic disc pallor (HP:0000543)	2.11036929
48	Aplasia/Hypoplasia of the macula (HP:0008059)	2.10234026
49	Increased serum lactate (HP:0002151)	2.09784963
50	Increased hepatocellular lipid droplets (HP:0006565)	2.09474753
51	Leukodystrophy (HP:0002415)	2.07592470
52	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07250570
53	Hepatic necrosis (HP:0002605)	2.06843904
54	Lactic acidosis (HP:0003128)	2.04032438
55	Sclerocornea (HP:0000647)	2.02518564
56	Methylmalonic aciduria (HP:0012120)	2.02390273
57	Entropion (HP:0000621)	2.01406855
58	Increased muscle lipid content (HP:0009058)	2.00326747
59	Anencephaly (HP:0002323)	1.99290031
60	Abnormality of chloride homeostasis (HP:0011422)	1.97900712
61	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.95335056
62	Attenuation of retinal blood vessels (HP:0007843)	1.94723330
63	Progressive visual loss (HP:0000529)	1.94183981
64	Adactyly (HP:0009776)	1.93026063
65	Palpebral edema (HP:0100540)	1.92764805
66	IgG deficiency (HP:0004315)	1.92384834
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90784743
68	Abnormality of the renal cortex (HP:0011035)	1.89962350
69	Increased cerebral lipofuscin (HP:0011813)	1.89800051
70	Congenital primary aphakia (HP:0007707)	1.89212622
71	Growth hormone deficiency (HP:0000824)	1.87537244
72	Fibular aplasia (HP:0002990)	1.87269340
73	Keratitis (HP:0000491)	1.86083452
74	Hyperinsulinemic hypoglycemia (HP:0000825)	1.85590338
75	Increased intramyocellular lipid droplets (HP:0012240)	1.84706184
76	Gait imbalance (HP:0002141)	1.82968983
77	Meckel diverticulum (HP:0002245)	1.82625518
78	Constricted visual fields (HP:0001133)	1.82485492
79	Retinal atrophy (HP:0001105)	1.82112030
80	Atonic seizures (HP:0010819)	1.81321826
81	Poor speech (HP:0002465)	1.81234062
82	Medial flaring of the eyebrow (HP:0010747)	1.80911381
83	Oligomenorrhea (HP:0000876)	1.79132021
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78759807
85	Cerebral hypomyelination (HP:0006808)	1.78489217
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78214299
87	Abnormality of midbrain morphology (HP:0002418)	1.78147204
88	Molar tooth sign on MRI (HP:0002419)	1.78147204
89	Abnormality of the ileum (HP:0001549)	1.77383020
90	Lethargy (HP:0001254)	1.75749386
91	Renal Fanconi syndrome (HP:0001994)	1.75378862
92	Congenital hepatic fibrosis (HP:0002612)	1.73105975
93	Furrowed tongue (HP:0000221)	1.72385403
94	Abnormality of the metopic suture (HP:0005556)	1.72344027
95	Polyphagia (HP:0002591)	1.71458819
96	Occipital encephalocele (HP:0002085)	1.71167947
97	Postaxial foot polydactyly (HP:0001830)	1.70190727
98	Pancytopenia (HP:0001876)	1.70102223
99	Nephrogenic diabetes insipidus (HP:0009806)	1.69162084
100	Abnormality of the renal medulla (HP:0100957)	1.68491018

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.59555992
2	EIF2AK1	3.46723637
3	PDK2	3.39640340
4	TSSK6	2.83256877
5	TAF1	2.57869391
6	TRIM28	2.43247453
7	PBK	2.43077977
8	EIF2AK3	2.40913028
9	AKT3	2.34986783
10	VRK2	2.29806337
11	MAP3K4	2.25192455
12	TYK2	2.23739585
13	SRPK1	2.17789901
14	KIT	2.16904772
15	FRK	1.82055061
16	NUAK1	1.69424113
17	BCKDK	1.67695679
18	INSRR	1.66157439
19	TXK	1.62740330
20	CSNK1G3	1.60875893
21	NEK1	1.58455145
22	CSNK1A1L	1.57851887
23	SIK3	1.54978080
24	BCR	1.54936848
25	ZAK	1.51050680
26	TEC	1.50821975
27	MKNK2	1.38431950
28	CSF1R	1.37885909
29	CSNK1G1	1.37563243
30	RPS6KA4	1.34113537
31	DYRK3	1.32679974
32	PINK1	1.28747311
33	IKBKE	1.25593807
34	CSNK1G2	1.22513495
35	GRK1	1.21057003
36	ADRBK2	1.18791653
37	PAK3	1.18484726
38	BRSK2	1.17005949
39	DAPK1	1.16708511
40	MAP3K6	1.15129854
41	PLK3	1.11905011
42	TLK1	1.07953341
43	CAMKK2	1.02825780
44	VRK1	0.95701734
45	MAP3K12	0.95472747
46	JAK3	0.94828200
47	TESK1	0.93274519
48	WEE1	0.91769962
49	MAPK11	0.91205643
50	PLK2	0.90105746
51	TAOK3	0.86127833
52	MINK1	0.84703936
53	CDK19	0.76271317
54	CAMK2D	0.73865776
55	ITK	0.73622698
56	RIPK4	0.70575522
57	EPHA3	0.68907517
58	PASK	0.67741903
59	CHEK2	0.65892737
60	PRKD3	0.64842199
61	EIF2AK2	0.64597116
62	SGK2	0.62651062
63	MYLK	0.59580779
64	MKNK1	0.59162875
65	FGR	0.57017214
66	TESK2	0.56756498
67	SYK	0.56140313
68	IKBKB	0.54418575
69	LIMK1	0.52852721
70	PLK1	0.50610664
71	CAMK2G	0.50341751
72	PHKG1	0.49196560
73	PHKG2	0.49196560
74	CCNB1	0.48130131
75	MAP2K7	0.47221962
76	TNK2	0.47110160
77	MAPKAPK5	0.47103165
78	BMPR1B	0.46629876
79	MAPKAPK3	0.44177770
80	RPS6KA5	0.43628055
81	MAP4K2	0.42972194
82	STK38L	0.42647626
83	PRKCE	0.41759222
84	IGF1R	0.41536642
85	ABL2	0.40860462
86	PTK2B	0.40777809
87	LATS1	0.40715014
88	BTK	0.39176189
89	MARK3	0.38187628
90	MAPK13	0.37928446
91	FGFR4	0.36635830
92	CASK	0.36002364
93	CSNK1A1	0.34857733
94	ATR	0.32092872
95	PRKCH	0.31887362
96	FLT3	0.31303764
97	DYRK2	0.29382851
98	FGFR3	0.27381555
99	PRKCI	0.26340214
100	ACVR1B	0.26133002

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.08855866
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.48293733
3	Sulfur metabolism_Homo sapiens_hsa00920	2.62830783
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45171121
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.24982029
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.11962020
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.08908058
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98311016
9	Tryptophan metabolism_Homo sapiens_hsa00380	1.93675125
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.91085701
11	Propanoate metabolism_Homo sapiens_hsa00640	1.84746045
12	Basal transcription factors_Homo sapiens_hsa03022	1.84506759
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.83575826
14	Protein export_Homo sapiens_hsa03060	1.75110030
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66639506
16	RNA polymerase_Homo sapiens_hsa03020	1.65194910
17	One carbon pool by folate_Homo sapiens_hsa00670	1.64689259
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61329950
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60965854
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59993700
21	Asthma_Homo sapiens_hsa05310	1.57438528
22	Peroxisome_Homo sapiens_hsa04146	1.52446503
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.50880342
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.45267716
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43653483
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41596843
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.39294970
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.38066656
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36675705
30	Parkinsons disease_Homo sapiens_hsa05012	1.35620196
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33560112
32	ABC transporters_Homo sapiens_hsa02010	1.31091450
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.29817095
34	Purine metabolism_Homo sapiens_hsa00230	1.27658123
35	Homologous recombination_Homo sapiens_hsa03440	1.27606643
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.21387675
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20888724
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20181764
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19943023
40	Allograft rejection_Homo sapiens_hsa05330	1.17078727
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.11175942
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09126644
43	Huntingtons disease_Homo sapiens_hsa05016	1.05790443
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05287585
45	Fatty acid elongation_Homo sapiens_hsa00062	1.04568755
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04491522
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03255070
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01800409
49	Ether lipid metabolism_Homo sapiens_hsa00565	1.01112252
50	Butanoate metabolism_Homo sapiens_hsa00650	1.00961026
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00959091
52	Histidine metabolism_Homo sapiens_hsa00340	0.96808629
53	Circadian rhythm_Homo sapiens_hsa04710	0.95823805
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95235597
55	Olfactory transduction_Homo sapiens_hsa04740	0.92454295
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.89547783
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88979239
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.88860912
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84606199
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84004755
61	Mismatch repair_Homo sapiens_hsa03430	0.83311199
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82660199
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81838639
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79696945
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.78735020
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77251934
67	Herpes simplex infection_Homo sapiens_hsa05168	0.77138838
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77133631
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76306397
70	Caffeine metabolism_Homo sapiens_hsa00232	0.75608121
71	RNA degradation_Homo sapiens_hsa03018	0.73336144
72	Regulation of autophagy_Homo sapiens_hsa04140	0.71703299
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68711825
74	Viral myocarditis_Homo sapiens_hsa05416	0.68483229
75	Lysosome_Homo sapiens_hsa04142	0.68014613
76	Glutathione metabolism_Homo sapiens_hsa00480	0.67772994
77	Metabolic pathways_Homo sapiens_hsa01100	0.66783490
78	Alzheimers disease_Homo sapiens_hsa05010	0.63550960
79	Base excision repair_Homo sapiens_hsa03410	0.62208102
80	Other glycan degradation_Homo sapiens_hsa00511	0.58614670
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57913781
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55063051
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53525292
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52100157
85	Phototransduction_Homo sapiens_hsa04744	0.50999672
86	Spliceosome_Homo sapiens_hsa03040	0.49874641
87	Nucleotide excision repair_Homo sapiens_hsa03420	0.46459479
88	Fatty acid degradation_Homo sapiens_hsa00071	0.45177524
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43334851
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43247267
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43239490
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41686543
93	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.40714321
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40406643
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39905106
96	Legionellosis_Homo sapiens_hsa05134	0.39634922
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38579878
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38422867
99	Taste transduction_Homo sapiens_hsa04742	0.38158418
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36086372

FDPSP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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