ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of glucokinase activity (GO:0033131)	7.32225285
2	regulation of hexokinase activity (GO:1903299)	7.32225285
3	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	6.52624292
4	regulation of type B pancreatic cell apoptotic process (GO:2000674)	5.97381968
5	cellular ketone body metabolic process (GO:0046950)	5.43925320
6	platelet dense granule organization (GO:0060155)	5.39666638
7	energy homeostasis (GO:0097009)	4.94490709
8	detection of light stimulus involved in sensory perception (GO:0050962)	4.86271694
9	detection of light stimulus involved in visual perception (GO:0050908)	4.86271694
10	dopamine transport (GO:0015872)	4.82362292
11	ketone body metabolic process (GO:1902224)	4.78485206
12	endosome to melanosome transport (GO:0035646)	4.54363045
13	endosome to pigment granule transport (GO:0043485)	4.54363045
14	catecholamine transport (GO:0051937)	4.46690710
15	nitric oxide mediated signal transduction (GO:0007263)	4.44137684
16	endocrine pancreas development (GO:0031018)	4.26714692
17	embryonic retina morphogenesis in camera-type eye (GO:0060059)	4.25642774
18	zinc ion homeostasis (GO:0055069)	4.23371429
19	glycerophospholipid catabolic process (GO:0046475)	4.18633336
20	auditory receptor cell differentiation (GO:0042491)	4.08610078
21	negative regulation of protein oligomerization (GO:0032460)	4.06503456
22	L-fucose catabolic process (GO:0042355)	3.96648780
23	fucose catabolic process (GO:0019317)	3.96648780
24	L-fucose metabolic process (GO:0042354)	3.96648780
25	protein K6-linked ubiquitination (GO:0085020)	3.95849807
26	lactate metabolic process (GO:0006089)	3.95459011
27	positive regulation of insulin secretion (GO:0032024)	3.87908579
28	xenobiotic catabolic process (GO:0042178)	3.72090445
29	insulin secretion (GO:0030073)	3.58406088
30	anterograde synaptic vesicle transport (GO:0048490)	3.54511914
31	positive regulation of peptide hormone secretion (GO:0090277)	3.53660070
32	RNA destabilization (GO:0050779)	3.53055821
33	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.45261216
34	monoamine transport (GO:0015844)	3.44094829
35	zinc ion transport (GO:0006829)	3.43044729
36	coenzyme catabolic process (GO:0009109)	3.37580216
37	positive regulation of peptide secretion (GO:0002793)	3.37321817
38	signal peptide processing (GO:0006465)	3.33153610
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.28676781
40	nephron tubule morphogenesis (GO:0072078)	3.27137028
41	nephron epithelium morphogenesis (GO:0072088)	3.27137028
42	positive regulation of glycolytic process (GO:0045821)	3.26650445
43	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.24569372
44	negative regulation of execution phase of apoptosis (GO:1900118)	3.22075325
45	regulation of insulin secretion (GO:0050796)	3.19940621
46	positive regulation of calcium ion import (GO:0090280)	3.17878193
47	mRNA modification (GO:0016556)	3.17612130
48	negative regulation of cAMP-mediated signaling (GO:0043951)	3.16671940
49	developmental pigmentation (GO:0048066)	3.11009968
50	water-soluble vitamin biosynthetic process (GO:0042364)	3.09332321
51	melanosome localization (GO:0032400)	3.08989541
52	urate metabolic process (GO:0046415)	3.07887874
53	brain morphogenesis (GO:0048854)	3.07161844
54	epithelial cell fate commitment (GO:0072148)	3.06943311
55	regulation of peptide hormone secretion (GO:0090276)	3.06322061
56	startle response (GO:0001964)	3.03900613
57	pigment granule localization (GO:0051875)	3.03563220
58	heme transport (GO:0015886)	3.02550847
59	negative regulation of JUN kinase activity (GO:0043508)	3.01281212
60	regulation of autophagic vacuole assembly (GO:2000785)	3.00562940
61	response to pheromone (GO:0019236)	2.98557043
62	regulation of peptide secretion (GO:0002791)	2.98360251
63	negative regulation of hormone biosynthetic process (GO:0032353)	2.94453034
64	glandular epithelial cell differentiation (GO:0002067)	2.92733788
65	L-alpha-amino acid transmembrane transport (GO:1902475)	2.90735540
66	dentate gyrus development (GO:0021542)	2.86277102
67	melanosome organization (GO:0032438)	2.85930914
68	negative regulation of neurological system process (GO:0031645)	2.80060686
69	inositol metabolic process (GO:0006020)	2.78881095
70	regulation of oxidative stress-induced neuron death (GO:1903203)	2.78408628
71	regulation of immunoglobulin secretion (GO:0051023)	2.76225557
72	maintenance of gastrointestinal epithelium (GO:0030277)	2.74438142
73	positive regulation of macroautophagy (GO:0016239)	2.73964150
74	negative regulation of acute inflammatory response (GO:0002674)	2.73709528
75	retinol metabolic process (GO:0042572)	2.73458453
76	regulation of vacuole organization (GO:0044088)	2.71807653
77	nitric oxide biosynthetic process (GO:0006809)	2.68818861
78	intestinal epithelial cell development (GO:0060576)	2.67085835
79	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.65239533
80	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.65239533
81	pigment granule organization (GO:0048753)	2.65135066
82	regulation of hormone secretion (GO:0046883)	2.59851421
83	regulation of mitochondrial translation (GO:0070129)	2.59720570
84	establishment of protein localization to Golgi (GO:0072600)	2.58963051
85	regulation of protein glycosylation (GO:0060049)	2.58837794
86	positive regulation of response to extracellular stimulus (GO:0032106)	2.58714939
87	positive regulation of response to nutrient levels (GO:0032109)	2.58714939
88	cytochrome complex assembly (GO:0017004)	2.58445309
89	renal tubule morphogenesis (GO:0061333)	2.57782297
90	peptide hormone processing (GO:0016486)	2.57655129
91	peptidyl-histidine modification (GO:0018202)	2.57593587
92	mitotic sister chromatid cohesion (GO:0007064)	2.56595676
93	cellular zinc ion homeostasis (GO:0006882)	2.56513204
94	phenylpropanoid metabolic process (GO:0009698)	2.55839526
95	regulation of peptide transport (GO:0090087)	2.54905492
96	positive regulation of hormone secretion (GO:0046887)	2.53253757
97	protein targeting to Golgi (GO:0000042)	2.52621206
98	protein polyglutamylation (GO:0018095)	2.51627427
99	response to nitrosative stress (GO:0051409)	2.51536417
100	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.50751493

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.36801052
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.10103331
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.39443052
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35868012
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.27613860
6	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.07264601
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00325208
8	GBX2_23144817_ChIP-Seq_PC3_Human	1.94520385
9	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92288101
10	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84292485
11	ER_23166858_ChIP-Seq_MCF-7_Human	1.82490533
12	EWS_26573619_Chip-Seq_HEK293_Human	1.77383300
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75873206
14	P300_19829295_ChIP-Seq_ESCs_Human	1.72068549
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72065323
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65839343
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64251027
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.63300306
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.61558357
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59337285
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.55857633
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51404110
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49596004
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46694862
25	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.44253981
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43793731
27	STAT3_23295773_ChIP-Seq_U87_Human	1.42661703
28	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.42433906
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38441891
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38175107
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37567233
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37567233
33	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.35841660
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35397845
35	VDR_22108803_ChIP-Seq_LS180_Human	1.31727417
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31339039
37	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.30750404
38	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29869800
39	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.29432190
40	FUS_26573619_Chip-Seq_HEK293_Human	1.28693797
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.28347724
42	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28272387
43	AR_25329375_ChIP-Seq_VCAP_Human	1.27013693
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25971136
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25971136
46	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25915965
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25486952
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25193268
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22758833
50	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.22457640
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.21533772
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20600864
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.19093404
54	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.18664425
55	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.17826962
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17424896
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17399285
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16712792
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16657816
60	NCOR_22424771_ChIP-Seq_293T_Human	1.15886158
61	TCF4_23295773_ChIP-Seq_U87_Human	1.15662935
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15205347
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.15187773
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15187773
65	NFYB_21822215_ChIP-Seq_K562_Human	1.14110158
66	NFYA_21822215_ChIP-Seq_K562_Human	1.13927128
67	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13831758
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.13781426
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13062511
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12496038
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10754274
72	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.10269117
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.10236725
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.09800460
75	TBL1_22424771_ChIP-Seq_293T_Human	1.09428760
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08875348
77	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.08853078
78	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08706229
79	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08548166
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07602642
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07267675
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07110558
83	PHF8_20622853_ChIP-Seq_HELA_Human	1.06509718
84	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06404461
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06200680
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05546227
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.05035267
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04582066
89	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.03378268
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02690279
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.02670311
92	GATA3_26560356_Chip-Seq_TH2_Human	1.02558388
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02408684
94	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.02398843
95	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.02300289
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02280786
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02185036
98	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.01968444
99	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01755720
100	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.01592418

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003172_abnormal_lysosome_physiology	4.16271410
2	MP0003195_calcinosis	4.04207081
3	MP0009780_abnormal_chondrocyte_physiolo	3.80347098
4	MP0000013_abnormal_adipose_tissue	3.76699442
5	MP0002138_abnormal_hepatobiliary_system	3.39224087
6	MP0006072_abnormal_retinal_apoptosis	3.14159154
7	MP0005174_abnormal_tail_pigmentation	3.07650990
8	MP0002837_dystrophic_cardiac_calcinosis	2.69667486
9	MP0002254_reproductive_system_inflammat	2.53785856
10	MP0003787_abnormal_imprinting	2.51397588
11	MP0000003_abnormal_adipose_tissue	2.48977011
12	MP0005075_abnormal_melanosome_morpholog	2.47256951
13	MP0005379_endocrine/exocrine_gland_phen	2.44398671
14	MP0002139_abnormal_hepatobiliary_system	2.32900434
15	MP0000015_abnormal_ear_pigmentation	2.32302221
16	MP0002909_abnormal_adrenal_gland	2.29945466
17	MP0002163_abnormal_gland_morphology	2.26625326
18	MP0008877_abnormal_DNA_methylation	2.26147540
19	MP0001944_abnormal_pancreas_morphology	2.22842016
20	MP0003283_abnormal_digestive_organ	2.10474900
21	MP0005646_abnormal_pituitary_gland	1.93213108
22	MP0005220_abnormal_exocrine_pancreas	1.92129777
23	MP0002693_abnormal_pancreas_physiology	1.86708544
24	MP0004381_abnormal_hair_follicle	1.82306753
25	MP0004019_abnormal_vitamin_homeostasis	1.80240426
26	MP0004147_increased_porphyrin_level	1.77200687
27	MP0008004_abnormal_stomach_pH	1.69981421
28	MP0005551_abnormal_eye_electrophysiolog	1.67515383
29	MP0002928_abnormal_bile_duct	1.64705368
30	MP0002876_abnormal_thyroid_physiology	1.60575624
31	MP0004885_abnormal_endolymph	1.50413162
32	MP0005084_abnormal_gallbladder_morpholo	1.47123798
33	MP0000569_abnormal_digit_pigmentation	1.46321933
34	MP0010307_abnormal_tumor_latency	1.45160399
35	MP0000371_diluted_coat_color	1.44738545
36	MP0003011_delayed_dark_adaptation	1.39229265
37	MP0003868_abnormal_feces_composition	1.37235251
38	MP0002078_abnormal_glucose_homeostasis	1.37171597
39	MP0002090_abnormal_vision	1.36553138
40	MP0003567_abnormal_fetal_cardiomyocyte	1.36100367
41	MP0010234_abnormal_vibrissa_follicle	1.32930716
42	MP0001984_abnormal_olfaction	1.29647228
43	MP0005253_abnormal_eye_physiology	1.28197018
44	MP0003122_maternal_imprinting	1.21677716
45	MP0001501_abnormal_sleep_pattern	1.20935395
46	MP0005332_abnormal_amino_acid	1.18603117
47	MP0002272_abnormal_nervous_system	1.17173908
48	MP0000427_abnormal_hair_cycle	1.15834710
49	MP0003045_fibrosis	1.13149636
50	MP0003879_abnormal_hair_cell	1.11851180
51	MP0005375_adipose_tissue_phenotype	1.09518993
52	MP0005365_abnormal_bile_salt	1.09319720
53	MP0005645_abnormal_hypothalamus_physiol	1.08528495
54	MP0003878_abnormal_ear_physiology	1.05167856
55	MP0005377_hearing/vestibular/ear_phenot	1.05167856
56	MP0005448_abnormal_energy_balance	1.04621192
57	MP0001324_abnormal_eye_pigmentation	1.03815883
58	MP0001986_abnormal_taste_sensitivity	1.03775115
59	MP0005636_abnormal_mineral_homeostasis	1.02504235
60	MP0001502_abnormal_circadian_rhythm	1.02218237
61	MP0000470_abnormal_stomach_morphology	0.98755973
62	MP0009046_muscle_twitch	0.98704686
63	MP0002166_altered_tumor_susceptibility	0.93359986
64	MP0003953_abnormal_hormone_level	0.92245447
65	MP0006036_abnormal_mitochondrial_physio	0.91518247
66	MP0009745_abnormal_behavioral_response	0.89835060
67	MP0002229_neurodegeneration	0.88867019
68	MP0001764_abnormal_homeostasis	0.86565252
69	MP0008872_abnormal_physiological_respon	0.85897233
70	MP0001440_abnormal_grooming_behavior	0.84523224
71	MP0005367_renal/urinary_system_phenotyp	0.81984988
72	MP0000516_abnormal_urinary_system	0.81984988
73	MP0003121_genomic_imprinting	0.81243433
74	MP0008961_abnormal_basal_metabolism	0.81233778
75	MP0002118_abnormal_lipid_homeostasis	0.80290105
76	MP0002102_abnormal_ear_morphology	0.78941063
77	MP0001485_abnormal_pinna_reflex	0.78661487
78	MP0005535_abnormal_body_temperature	0.77640457
79	MP0001905_abnormal_dopamine_level	0.76434759
80	MP0008875_abnormal_xenobiotic_pharmacok	0.74335085
81	MP0010678_abnormal_skin_adnexa	0.74039834
82	MP0002095_abnormal_skin_pigmentation	0.72978350
83	MP0010329_abnormal_lipoprotein_level	0.69432811
84	MP0010386_abnormal_urinary_bladder	0.69414766
85	MP0004142_abnormal_muscle_tone	0.69114002
86	MP0005310_abnormal_salivary_gland	0.67696082
87	MP0003724_increased_susceptibility_to	0.67223008
88	MP0001765_abnormal_ion_homeostasis	0.66588268
89	MP0004043_abnormal_pH_regulation	0.66427248
90	MP0001919_abnormal_reproductive_system	0.66192352
91	MP0003123_paternal_imprinting	0.65098868
92	MP0009643_abnormal_urine_homeostasis	0.64115510
93	MP0003186_abnormal_redox_activity	0.63618507
94	MP0003633_abnormal_nervous_system	0.63514749
95	MP0001756_abnormal_urination	0.63159291
96	MP0002168_other_aberrant_phenotype	0.62033605
97	MP0002572_abnormal_emotion/affect_behav	0.58946943
98	MP0001664_abnormal_digestion	0.58874521
99	MP0003252_abnormal_bile_duct	0.58838828
100	MP0002006_tumorigenesis	0.57378070

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	6.09769701
2	Hypoglycemic seizures (HP:0002173)	5.80005843
3	Hypoplasia of the fovea (HP:0007750)	5.65675048
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.65675048
5	Hypoglycemic coma (HP:0001325)	4.96937944
6	Abnormality of the fovea (HP:0000493)	4.47898173
7	Hypothermia (HP:0002045)	4.30374140
8	Albinism (HP:0001022)	4.12650236
9	Ketoacidosis (HP:0001993)	3.99209887
10	Pigmentary retinal degeneration (HP:0001146)	3.93006597
11	Aplasia/Hypoplasia of the macula (HP:0008059)	3.75538416
12	Symptomatic seizures (HP:0011145)	3.73328137
13	Abnormality of the renal cortex (HP:0011035)	3.49718867
14	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.44889210
15	Late onset (HP:0003584)	3.39796044
16	Aplasia/hypoplasia of the uterus (HP:0008684)	3.34254342
17	Hypoplasia of the uterus (HP:0000013)	3.32994013
18	Hyperglycemia (HP:0003074)	3.32123996
19	Abnormality of lateral ventricle (HP:0030047)	3.22030330
20	Ketosis (HP:0001946)	3.21454794
21	Insulin-resistant diabetes mellitus (HP:0000831)	3.16892791
22	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.08234774
23	Generalized hypopigmentation (HP:0007513)	3.07791276
24	Prominent metopic ridge (HP:0005487)	3.00151650
25	Hypomagnesemia (HP:0002917)	2.99397787
26	Retinal atrophy (HP:0001105)	2.99029629
27	Abnormality of endocrine pancreas physiology (HP:0012093)	2.98829214
28	Abnormality of the pancreatic islet cells (HP:0006476)	2.98829214
29	Abnormal pancreas size (HP:0012094)	2.94386596
30	Tongue fasciculations (HP:0001308)	2.84178254
31	Anterior segment dysgenesis (HP:0007700)	2.84152016
32	Large for gestational age (HP:0001520)	2.83793571
33	Pancreatic islet-cell hyperplasia (HP:0004510)	2.83666133
34	Hypoalbuminemia (HP:0003073)	2.80944885
35	Abnormal albumin level (HP:0012116)	2.80944885
36	Congenital stationary night blindness (HP:0007642)	2.80180184
37	Renal cortical cysts (HP:0000803)	2.78264292
38	Enlarged penis (HP:0000040)	2.76559358
39	Febrile seizures (HP:0002373)	2.65389467
40	Ocular albinism (HP:0001107)	2.57193535
41	Hematochezia (HP:0002573)	2.55071475
42	Abnormal drinking behavior (HP:0030082)	2.54138669
43	Polydipsia (HP:0001959)	2.54138669
44	Stomatitis (HP:0010280)	2.53028556
45	Abnormality of the metopic suture (HP:0005556)	2.52968275
46	Muscle fibrillation (HP:0010546)	2.51142907
47	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.48638065
48	Severe muscular hypotonia (HP:0006829)	2.44805677
49	Generalized hypopigmentation of hair (HP:0011358)	2.44197177
50	Hemiparesis (HP:0001269)	2.41736822
51	Gaze-evoked nystagmus (HP:0000640)	2.41054100
52	Stridor (HP:0010307)	2.38249113
53	Polyuria (HP:0000103)	2.31936931
54	Iris hypopigmentation (HP:0007730)	2.31200937
55	Abnormality of midbrain morphology (HP:0002418)	2.28869751
56	Molar tooth sign on MRI (HP:0002419)	2.28869751
57	Abnormality of the renal medulla (HP:0100957)	2.26754102
58	Thyroiditis (HP:0100646)	2.21931448
59	Neoplasm of the tracheobronchial system (HP:0100552)	2.20129348
60	Abnormality of magnesium homeostasis (HP:0004921)	2.17993078
61	Alveolar cell carcinoma (HP:0006519)	2.14518032
62	Hypobetalipoproteinemia (HP:0003563)	2.14175834
63	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.10262371
64	Abnormality of macular pigmentation (HP:0008002)	2.06722095
65	Nephronophthisis (HP:0000090)	2.03945929
66	Choroideremia (HP:0001139)	2.02501307
67	Increased CSF protein (HP:0002922)	2.00493155
68	Oligodactyly (hands) (HP:0001180)	2.00389086
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.99759123
70	Prolonged partial thromboplastin time (HP:0003645)	1.99136765
71	Methylmalonic acidemia (HP:0002912)	1.98176347
72	Postural tremor (HP:0002174)	1.96739788
73	Aqueductal stenosis (HP:0002410)	1.94298889
74	Intellectual disability, progressive (HP:0006887)	1.93476262
75	Hyperventilation (HP:0002883)	1.93105422
76	Vacuolated lymphocytes (HP:0001922)	1.92731302
77	Progressive macrocephaly (HP:0004481)	1.90527276
78	Double outlet right ventricle (HP:0001719)	1.90412494
79	Congenital malformation of the right heart (HP:0011723)	1.90412494
80	Disproportionate short-trunk short stature (HP:0003521)	1.89358461
81	Malnutrition (HP:0004395)	1.89001449
82	Increased circulating renin level (HP:0000848)	1.88537383
83	Abnormal urine output (HP:0012590)	1.85865624
84	Abnormality of vitamin B metabolism (HP:0004340)	1.85683165
85	EEG with generalized epileptiform discharges (HP:0011198)	1.84623186
86	Type I diabetes mellitus (HP:0100651)	1.84240785
87	Unilateral renal agenesis (HP:0000122)	1.84207567
88	Bilateral sensorineural hearing impairment (HP:0008619)	1.82509034
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.76309181
90	Furrowed tongue (HP:0000221)	1.75562830
91	Downturned corners of mouth (HP:0002714)	1.73183082
92	Abnormality of methionine metabolism (HP:0010901)	1.73034898
93	Epileptiform EEG discharges (HP:0011182)	1.72754558
94	Abnormality of the line of Schwalbe (HP:0008048)	1.71337105
95	Insulin resistance (HP:0000855)	1.70676138
96	Hypsarrhythmia (HP:0002521)	1.70371814
97	Chronic hepatic failure (HP:0100626)	1.70356946
98	Glucose intolerance (HP:0000833)	1.69514597
99	Hepatic necrosis (HP:0002605)	1.67243168
100	Abnormality of fatty-acid metabolism (HP:0004359)	1.66567950

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.58325336
2	PINK1	4.65898160
3	MST4	4.36168376
4	PRKD3	4.07807002
5	TLK1	3.15023705
6	FGFR2	2.92703795
7	ZAK	2.85714462
8	CASK	2.51966860
9	FLT3	2.33962823
10	PKN2	2.27309264
11	ADRBK2	2.24392923
12	PHKG1	2.07805976
13	PHKG2	2.07805976
14	FGFR3	1.72499904
15	MAP4K2	1.71644072
16	WNK4	1.70883066
17	PASK	1.69158777
18	NUAK1	1.56988888
19	DAPK2	1.53953979
20	GRK1	1.42621905
21	TRPM7	1.37813800
22	PAK3	1.33517847
23	STK16	1.32513526
24	TXK	1.30536253
25	STK38L	1.23055841
26	MAP2K6	1.15095255
27	VRK1	1.13188442
28	STK10	1.10402952
29	PRKCE	1.09515518
30	TNIK	1.06407172
31	CAMKK2	1.05798796
32	WNK3	1.05456257
33	PTK2B	1.04426153
34	PLK2	1.04224166
35	STK39	1.01789745
36	HIPK2	1.01757782
37	TAOK1	1.00445513
38	INSRR	0.99761620
39	MAP3K12	0.98917073
40	NLK	0.94585993
41	STK3	0.93576875
42	BMPR2	0.90543016
43	ERBB3	0.86479341
44	STK4	0.84280403
45	STK24	0.84273228
46	YES1	0.82895475
47	IKBKE	0.80900273
48	EIF2AK3	0.80784914
49	BMPR1B	0.77215312
50	JAK1	0.73723828
51	PRKCI	0.72826580
52	PRKAA2	0.71560949
53	TNK2	0.71275514
54	PRKCQ	0.68490531
55	IRAK1	0.62669196
56	LRRK2	0.61934884
57	IKBKB	0.61650079
58	EPHA3	0.61421655
59	ADRBK1	0.60557352
60	PLK3	0.58727092
61	PRKAA1	0.54817183
62	CAMK1G	0.54672002
63	IRAK4	0.52883552
64	CHUK	0.52428324
65	OXSR1	0.52208060
66	BCKDK	0.51722324
67	ROCK1	0.50561063
68	PIM1	0.47118620
69	FER	0.47023993
70	PDK2	0.46281197
71	PRKCH	0.44937556
72	PDK1	0.44208132
73	NTRK3	0.41610944
74	PTK2	0.41200891
75	RPS6KA5	0.38844229
76	TSSK6	0.38801384
77	MKNK2	0.37735552
78	WNK1	0.36970559
79	STK11	0.36005387
80	TYK2	0.35823123
81	CAMK1D	0.35302066
82	SGK3	0.35148747
83	MAP4K1	0.34212846
84	TAOK3	0.33680157
85	CAMK2D	0.33168077
86	MAP3K2	0.33098779
87	PRKCG	0.32817753
88	TAF1	0.32790589
89	TEC	0.29395460
90	PIK3CA	0.27222514
91	CDK12	0.26978677
92	SGK1	0.26254879
93	EIF2AK1	0.23887302
94	MAP3K5	0.21790938
95	CSNK1A1	0.21505319
96	MAP3K1	0.19673547
97	PRKCZ	0.18403278
98	SGK2	0.15776930
99	MAP3K7	0.15330773
100	EGFR	0.15103324

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	6.90479958
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.82838251
3	Butanoate metabolism_Homo sapiens_hsa00650	3.78167961
4	Protein export_Homo sapiens_hsa03060	2.89675389
5	Insulin secretion_Homo sapiens_hsa04911	2.51288954
6	Peroxisome_Homo sapiens_hsa04146	2.31489653
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.21218357
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10739566
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.10031542
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.07160109
11	Regulation of autophagy_Homo sapiens_hsa04140	1.89737052
12	Mineral absorption_Homo sapiens_hsa04978	1.70031332
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.68400649
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.59968687
15	Folate biosynthesis_Homo sapiens_hsa00790	1.58279433
16	Fatty acid elongation_Homo sapiens_hsa00062	1.56455381
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52306451
18	Phototransduction_Homo sapiens_hsa04744	1.45243136
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39834109
20	Circadian rhythm_Homo sapiens_hsa04710	1.39729445
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39702450
22	Type II diabetes mellitus_Homo sapiens_hsa04930	1.30323168
23	ABC transporters_Homo sapiens_hsa02010	1.29747799
24	Propanoate metabolism_Homo sapiens_hsa00640	1.29385661
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25891956
26	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.21330123
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20319183
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.18572807
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18133941
30	Fatty acid degradation_Homo sapiens_hsa00071	1.15768768
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.10103292
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.09382601
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.07032584
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.01088137
35	Sulfur metabolism_Homo sapiens_hsa00920	0.99605139
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97526785
37	Basal transcription factors_Homo sapiens_hsa03022	0.90954873
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88610838
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.88593632
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88107498
41	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.83595321
42	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.80635893
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80238872
44	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79213276
45	Glucagon signaling pathway_Homo sapiens_hsa04922	0.76127017
46	Serotonergic synapse_Homo sapiens_hsa04726	0.75723238
47	RNA polymerase_Homo sapiens_hsa03020	0.75353540
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75132893
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74248358
50	Salivary secretion_Homo sapiens_hsa04970	0.71673518
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71479697
52	Renin secretion_Homo sapiens_hsa04924	0.70611226
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.70406542
54	Retinol metabolism_Homo sapiens_hsa00830	0.70135521
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69621451
56	Parkinsons disease_Homo sapiens_hsa05012	0.68704605
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.65071952
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63966780
59	Galactose metabolism_Homo sapiens_hsa00052	0.63652658
60	Legionellosis_Homo sapiens_hsa05134	0.62706445
61	Gastric acid secretion_Homo sapiens_hsa04971	0.57230453
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54124077
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53463955
64	Pancreatic secretion_Homo sapiens_hsa04972	0.53043446
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52276309
66	RNA degradation_Homo sapiens_hsa03018	0.51984034
67	Insulin resistance_Homo sapiens_hsa04931	0.49733942
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49341961
69	Metabolic pathways_Homo sapiens_hsa01100	0.46988322
70	African trypanosomiasis_Homo sapiens_hsa05143	0.46652574
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46278706
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40450833
73	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.39805395
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39456201
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38021340
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37180078
77	Caffeine metabolism_Homo sapiens_hsa00232	0.36410728
78	Long-term depression_Homo sapiens_hsa04730	0.36143871
79	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36129214
80	Complement and coagulation cascades_Homo sapiens_hsa04610	0.34767956
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34751679
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33640057
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32810304
84	Alzheimers disease_Homo sapiens_hsa05010	0.32633733
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32513361
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31807217
87	Proteasome_Homo sapiens_hsa03050	0.31169752
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.30048297
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29613470
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.28808509
91	GABAergic synapse_Homo sapiens_hsa04727	0.28121708
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.27984133
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27969085
94	Bile secretion_Homo sapiens_hsa04976	0.27296401
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27252232
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.25982748
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24599597
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.24333591
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.23949897
100	Lysosome_Homo sapiens_hsa04142	0.23280424

FDPSP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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