FDPSP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.28746562
2DNA double-strand break processing (GO:0000729)4.79324500
3water-soluble vitamin biosynthetic process (GO:0042364)4.58471309
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.52911683
5regulation of mitotic spindle checkpoint (GO:1903504)4.52911683
6regulation of mesoderm development (GO:2000380)4.18075739
7GDP-mannose metabolic process (GO:0019673)4.08568874
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.06773146
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.06773146
10peptidyl-histidine modification (GO:0018202)4.00805694
11somite rostral/caudal axis specification (GO:0032525)4.00589208
12glycosphingolipid biosynthetic process (GO:0006688)3.77188637
13aggressive behavior (GO:0002118)3.62933692
14cullin deneddylation (GO:0010388)3.55274377
15cellular response to zinc ion (GO:0071294)3.53802860
16positive regulation of gastrulation (GO:2000543)3.52057923
17DNA replication-dependent nucleosome assembly (GO:0006335)3.38059161
18DNA replication-dependent nucleosome organization (GO:0034723)3.38059161
19kynurenine metabolic process (GO:0070189)3.31552159
20sterol biosynthetic process (GO:0016126)3.30968241
21protein deneddylation (GO:0000338)3.30263603
22endoderm formation (GO:0001706)3.29075827
23cholesterol biosynthetic process (GO:0006695)3.21378110
24nucleotide-sugar biosynthetic process (GO:0009226)3.19722843
25positive regulation of heat generation (GO:0031652)3.17275698
26myelin assembly (GO:0032288)3.13541533
27piRNA metabolic process (GO:0034587)3.10459310
28nephron tubule morphogenesis (GO:0072078)3.10220756
29nephron epithelium morphogenesis (GO:0072088)3.10220756
30rRNA catabolic process (GO:0016075)3.09466903
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07970734
32regulation of action potential (GO:0098900)3.06868944
33detection of light stimulus involved in visual perception (GO:0050908)3.05411318
34detection of light stimulus involved in sensory perception (GO:0050962)3.05411318
35DNA deamination (GO:0045006)3.02352449
36indole-containing compound catabolic process (GO:0042436)3.02185313
37indolalkylamine catabolic process (GO:0046218)3.02185313
38tryptophan catabolic process (GO:0006569)3.02185313
39preassembly of GPI anchor in ER membrane (GO:0016254)3.01831557
40intraciliary transport (GO:0042073)2.96915007
41regulation of synapse structural plasticity (GO:0051823)2.92755911
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91210360
43DNA replication checkpoint (GO:0000076)2.89085914
44resolution of meiotic recombination intermediates (GO:0000712)2.88066350
45cell-cell junction maintenance (GO:0045217)2.87757826
46adaptation of signaling pathway (GO:0023058)2.83599661
47phenylpropanoid metabolic process (GO:0009698)2.82026668
48proteasome assembly (GO:0043248)2.81415851
49dendritic spine morphogenesis (GO:0060997)2.81318062
50double-strand break repair via homologous recombination (GO:0000724)2.79598062
51DNA damage response, detection of DNA damage (GO:0042769)2.79449249
52regulation of nuclear cell cycle DNA replication (GO:0033262)2.79171908
53respiratory chain complex IV assembly (GO:0008535)2.78620430
54vitamin catabolic process (GO:0009111)2.78298489
55fat-soluble vitamin catabolic process (GO:0042363)2.78298489
56meiotic chromosome segregation (GO:0045132)2.77448135
57DNA catabolic process, exonucleolytic (GO:0000738)2.77400187
58CENP-A containing nucleosome assembly (GO:0034080)2.77153865
59recombinational repair (GO:0000725)2.76131681
60chromatin remodeling at centromere (GO:0031055)2.75900035
61negative regulation of thymocyte apoptotic process (GO:0070244)2.75211679
62synaptic transmission, cholinergic (GO:0007271)2.74398378
63estrogen biosynthetic process (GO:0006703)2.73895589
64protein neddylation (GO:0045116)2.72991731
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.70007333
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67684828
67somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66044031
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.66044031
69adenosine metabolic process (GO:0046085)2.65982439
70sequestering of extracellular ligand from receptor (GO:0035581)2.65406482
71nucleoside diphosphate catabolic process (GO:0009134)2.63971016
72cellular ketone body metabolic process (GO:0046950)2.62594512
73positive regulation of mRNA processing (GO:0050685)2.62244080
74positive regulation of mRNA metabolic process (GO:1903313)2.58457804
75organelle disassembly (GO:1903008)2.55502928
76intra-Golgi vesicle-mediated transport (GO:0006891)2.55052790
77cell junction maintenance (GO:0034331)2.53108516
78phospholipid scrambling (GO:0017121)2.51082599
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50154638
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49960687
81regulation of heat generation (GO:0031650)2.47826048
82sialylation (GO:0097503)2.47245058
83regulation of cilium movement (GO:0003352)2.45321118
84positive regulation of B cell differentiation (GO:0045579)2.44812306
85regulation of acyl-CoA biosynthetic process (GO:0050812)2.44606944
86Rap protein signal transduction (GO:0032486)2.43491302
87transcription elongation from RNA polymerase I promoter (GO:0006362)2.42451106
88protein prenylation (GO:0018342)2.41991660
89prenylation (GO:0097354)2.41991660
90regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.41176677
91indolalkylamine metabolic process (GO:0006586)2.41155659
92protein polyglutamylation (GO:0018095)2.39474648
93DNA strand renaturation (GO:0000733)2.38691248
94platelet dense granule organization (GO:0060155)2.38541694
95replication fork processing (GO:0031297)2.38042151
96postreplication repair (GO:0006301)2.37131948
97negative regulation of activin receptor signaling pathway (GO:0032926)2.36150239
98isoprenoid biosynthetic process (GO:0008299)2.35841388
99peroxisome fission (GO:0016559)2.35456977
100centriole replication (GO:0007099)2.35183671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99854448
2ZNF274_21170338_ChIP-Seq_K562_Hela3.25235204
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17187773
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.14201739
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11895130
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70084620
7VDR_22108803_ChIP-Seq_LS180_Human2.63080958
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50708191
9EWS_26573619_Chip-Seq_HEK293_Human2.45596422
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.44151373
11VDR_23849224_ChIP-Seq_CD4+_Human2.36847128
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.30707781
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24583050
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.20832061
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20323906
16ELK1_19687146_ChIP-ChIP_HELA_Human2.17366665
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17287605
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96332296
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93097006
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91921570
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91392744
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91300931
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90180673
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88355007
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87072764
26TP53_22573176_ChIP-Seq_HFKS_Human1.86197643
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.82097141
28GATA1_22025678_ChIP-Seq_K562_Human1.81215965
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76734276
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74324604
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70186857
32TAF15_26573619_Chip-Seq_HEK293_Human1.69207344
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.65900697
34P300_19829295_ChIP-Seq_ESCs_Human1.64417216
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64249141
36FUS_26573619_Chip-Seq_HEK293_Human1.62977524
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59270117
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54003552
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50812335
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.45309339
41GBX2_23144817_ChIP-Seq_PC3_Human1.44886912
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42694884
43MYC_18940864_ChIP-ChIP_HL60_Human1.42032420
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41861332
45EZH2_22144423_ChIP-Seq_EOC_Human1.38615497
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37755249
47IGF1R_20145208_ChIP-Seq_DFB_Human1.36681291
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36023962
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35527078
50NANOG_19829295_ChIP-Seq_ESCs_Human1.33516487
51SOX2_19829295_ChIP-Seq_ESCs_Human1.33516487
52IRF1_19129219_ChIP-ChIP_H3396_Human1.33021176
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32330681
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31411505
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30996866
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29397692
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27427770
58FOXP3_21729870_ChIP-Seq_TREG_Human1.26360774
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24977989
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24610927
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24413566
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.22241369
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21487415
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20618974
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19509398
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.19509398
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17789397
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16298123
69CBP_20019798_ChIP-Seq_JUKART_Human1.15702703
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15702703
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15147265
72NCOR_22424771_ChIP-Seq_293T_Human1.14810720
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14545190
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.13867187
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12644966
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12470359
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11560903
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10807338
79TCF4_22108803_ChIP-Seq_LS180_Human1.10174627
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10079343
81GABP_19822575_ChIP-Seq_HepG2_Human1.08071176
82BCAT_22108803_ChIP-Seq_LS180_Human1.07748848
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.07664343
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07179538
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04926374
86ER_23166858_ChIP-Seq_MCF-7_Human1.04711007
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04086027
88STAT3_23295773_ChIP-Seq_U87_Human1.02136350
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.02026980
90FOXH1_21741376_ChIP-Seq_EPCs_Human1.01413944
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.01276435
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00155148
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00155148
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97584474
95HOXB7_26014856_ChIP-Seq_BT474_Human0.97325843
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96809145
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96642357
98EOMES_21245162_ChIP-Seq_HESCs_Human0.96056070
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95167633
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94633540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.10419991
2MP0003880_abnormal_central_pattern2.99899417
3MP0010386_abnormal_urinary_bladder2.92567012
4MP0005083_abnormal_biliary_tract2.77704001
5MP0003890_abnormal_embryonic-extraembry2.66828270
6MP0002736_abnormal_nociception_after2.65834583
7MP0000372_irregular_coat_pigmentation2.63288107
8MP0005645_abnormal_hypothalamus_physiol2.61550013
9MP0001968_abnormal_touch/_nociception2.48764388
10MP0002638_abnormal_pupillary_reflex2.39883737
11MP0001986_abnormal_taste_sensitivity2.30565396
12MP0008877_abnormal_DNA_methylation2.15286298
13MP0004043_abnormal_pH_regulation2.11736281
14MP0008872_abnormal_physiological_respon2.10962439
15MP0001984_abnormal_olfaction1.93011770
16MP0005551_abnormal_eye_electrophysiolog1.91757645
17MP0004885_abnormal_endolymph1.91296108
18MP0004215_abnormal_myocardial_fiber1.82711885
19MP0003806_abnormal_nucleotide_metabolis1.81511155
20MP0001529_abnormal_vocalization1.81331241
21MP0008875_abnormal_xenobiotic_pharmacok1.78237398
22MP0005084_abnormal_gallbladder_morpholo1.74243151
23MP0006036_abnormal_mitochondrial_physio1.71535005
24MP0008961_abnormal_basal_metabolism1.71268101
25MP0003011_delayed_dark_adaptation1.71087129
26MP0003718_maternal_effect1.71018478
27MP0006276_abnormal_autonomic_nervous1.61673155
28MP0002909_abnormal_adrenal_gland1.60814875
29MP0002938_white_spotting1.54544053
30MP0001970_abnormal_pain_threshold1.49407555
31MP0003119_abnormal_digestive_system1.45963791
32MP0004133_heterotaxia1.45247466
33MP0006054_spinal_hemorrhage1.43929383
34MP0002277_abnormal_respiratory_mucosa1.42388227
35MP0002876_abnormal_thyroid_physiology1.42364168
36MP0003195_calcinosis1.41799429
37MP0001486_abnormal_startle_reflex1.41797053
38MP0001905_abnormal_dopamine_level1.37137803
39MP0002272_abnormal_nervous_system1.36476971
40MP0003787_abnormal_imprinting1.36276490
41MP0009840_abnormal_foam_cell1.35988287
42MP0005253_abnormal_eye_physiology1.35393079
43MP0002734_abnormal_mechanical_nocicepti1.35203238
44MP0009745_abnormal_behavioral_response1.28170410
45MP0001756_abnormal_urination1.25518557
46MP0006072_abnormal_retinal_apoptosis1.23563967
47MP0009046_muscle_twitch1.21848682
48MP0000538_abnormal_urinary_bladder1.20786011
49MP0002102_abnormal_ear_morphology1.18312288
50MP0003279_aneurysm1.18288391
51MP0005174_abnormal_tail_pigmentation1.16066087
52MP0002572_abnormal_emotion/affect_behav1.15964768
53MP0005499_abnormal_olfactory_system1.10617742
54MP0005394_taste/olfaction_phenotype1.10617742
55MP0005410_abnormal_fertilization1.10423839
56MP0008058_abnormal_DNA_repair1.10394695
57MP0001501_abnormal_sleep_pattern1.08625562
58MP0001502_abnormal_circadian_rhythm1.08143441
59MP0003646_muscle_fatigue1.06003861
60MP0002557_abnormal_social/conspecific_i1.05555404
61MP0002735_abnormal_chemical_nociception1.03315450
62MP0009764_decreased_sensitivity_to1.00961252
63MP0008775_abnormal_heart_ventricle1.00287670
64MP0005310_abnormal_salivary_gland0.99273349
65MP0000751_myopathy0.97590250
66MP0008057_abnormal_DNA_replication0.97158638
67MP0002751_abnormal_autonomic_nervous0.96470325
68MP0003137_abnormal_impulse_conducting0.94199318
69MP0004145_abnormal_muscle_electrophysio0.94005602
70MP0000639_abnormal_adrenal_gland0.93086572
71MP0002064_seizures0.92828744
72MP0005389_reproductive_system_phenotype0.92613031
73MP0003786_premature_aging0.92333511
74MP0002138_abnormal_hepatobiliary_system0.91685234
75MP0002160_abnormal_reproductive_system0.90973137
76MP0002733_abnormal_thermal_nociception0.88992631
77MP0008004_abnormal_stomach_pH0.88605402
78MP0005075_abnormal_melanosome_morpholog0.87520214
79MP0004142_abnormal_muscle_tone0.87489768
80MP0004924_abnormal_behavior0.86598884
81MP0005386_behavior/neurological_phenoty0.86598884
82MP0003635_abnormal_synaptic_transmissio0.86034382
83MP0001764_abnormal_homeostasis0.84311183
84MP0006035_abnormal_mitochondrial_morpho0.82540473
85MP0005167_abnormal_blood-brain_barrier0.79879153
86MP0003943_abnormal_hepatobiliary_system0.79654272
87MP0002837_dystrophic_cardiac_calcinosis0.79350046
88MP0001919_abnormal_reproductive_system0.79026653
89MP0002067_abnormal_sensory_capabilities0.78970717
90MP0004085_abnormal_heartbeat0.78278039
91MP0001879_abnormal_lymphatic_vessel0.77834678
92MP0005535_abnormal_body_temperature0.77786513
93MP0005330_cardiomyopathy0.77670575
94MP0004270_analgesia0.76548295
95MP0010094_abnormal_chromosome_stability0.76548006
96MP0002063_abnormal_learning/memory/cond0.75866577
97MP0005671_abnormal_response_to0.75512819
98MP0002184_abnormal_innervation0.74746499
99MP0002332_abnormal_exercise_endurance0.72367570
100MP0001188_hyperpigmentation0.71840539

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.82689046
2Hyperalaninemia (HP:0003348)4.82689046
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.82689046
4Molar tooth sign on MRI (HP:0002419)3.91998607
5Abnormality of midbrain morphology (HP:0002418)3.91998607
6Progressive inability to walk (HP:0002505)3.88148828
7Hypoplasia of the pons (HP:0012110)3.85775063
8Abnormality of the pancreatic islet cells (HP:0006476)3.79321237
9Abnormality of endocrine pancreas physiology (HP:0012093)3.79321237
10Microretrognathia (HP:0000308)3.65772317
11Abnormality of the pons (HP:0007361)3.49623858
12Methylmalonic acidemia (HP:0002912)3.33744358
13Rectovaginal fistula (HP:0000143)3.32765009
14Rectal fistula (HP:0100590)3.32765009
15Ketoacidosis (HP:0001993)3.31049795
16Increased serum pyruvate (HP:0003542)3.26077657
17Attenuation of retinal blood vessels (HP:0007843)3.05973168
18Abnormality of glycolysis (HP:0004366)3.03678848
19Pendular nystagmus (HP:0012043)2.98337732
20Prolonged partial thromboplastin time (HP:0003645)2.91689823
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.90650957
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.90650957
23Lipid accumulation in hepatocytes (HP:0006561)2.89072243
24Amyotrophic lateral sclerosis (HP:0007354)2.82721815
25Vaginal fistula (HP:0004320)2.78633415
26Increased hepatocellular lipid droplets (HP:0006565)2.78235275
27Abnormality of placental membranes (HP:0011409)2.74368659
28Amniotic constriction ring (HP:0009775)2.74368659
29Hypoplastic pelvis (HP:0008839)2.72754011
30Congenital stationary night blindness (HP:0007642)2.71132405
31Methylmalonic aciduria (HP:0012120)2.70274392
32Hyperinsulinemic hypoglycemia (HP:0000825)2.68640005
33Pancreatic islet-cell hyperplasia (HP:0004510)2.66057606
34Intestinal fistula (HP:0100819)2.65981662
35Ketosis (HP:0001946)2.60051445
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58502539
37Abnormality of serum amino acid levels (HP:0003112)2.57297364
383-Methylglutaconic aciduria (HP:0003535)2.52450133
39Inability to walk (HP:0002540)2.44066086
40Nephronophthisis (HP:0000090)2.41237611
41Hyperglycinemia (HP:0002154)2.40261304
42Abnormality of the corticospinal tract (HP:0002492)2.36437184
43Pachygyria (HP:0001302)2.30593284
44Adrenal hypoplasia (HP:0000835)2.29110243
45Increased CSF lactate (HP:0002490)2.28096231
46Abnormal biliary tract physiology (HP:0012439)2.26452264
47Bile duct proliferation (HP:0001408)2.26452264
48Abolished electroretinogram (ERG) (HP:0000550)2.20109666
49Pancreatic cysts (HP:0001737)2.19352831
50Squamous cell carcinoma (HP:0002860)2.15221292
51Reduced antithrombin III activity (HP:0001976)2.14568266
52Visual hallucinations (HP:0002367)2.13015158
53Rib fusion (HP:0000902)2.10939881
54Hypoalbuminemia (HP:0003073)2.09679363
55Abnormal albumin level (HP:0012116)2.09679363
56Abnormality of the phalanges of the hallux (HP:0010057)2.09088347
57Generalized hypotonia (HP:0001290)2.08141550
58Increased serum lactate (HP:0002151)2.07544112
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06859882
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.05733674
61Type I transferrin isoform profile (HP:0003642)2.04381075
62Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04282434
63Bony spicule pigmentary retinopathy (HP:0007737)1.99362361
64Partial duplication of the phalanx of hand (HP:0009999)1.98745960
65Anencephaly (HP:0002323)1.98421191
66Renal Fanconi syndrome (HP:0001994)1.98151602
67Adactyly (HP:0009776)1.97820292
68Pancreatic fibrosis (HP:0100732)1.97049123
69Partial duplication of thumb phalanx (HP:0009944)1.97021155
70Chronic hepatic failure (HP:0100626)1.96413952
71Mitochondrial inheritance (HP:0001427)1.94966550
72Acute necrotizing encephalopathy (HP:0006965)1.89111592
73Aplasia of the musculature (HP:0100854)1.88222264
74Abnormality of vitamin B metabolism (HP:0004340)1.87346533
75Epiphyseal stippling (HP:0010655)1.87188366
76Optic disc pallor (HP:0000543)1.86991822
77IgG deficiency (HP:0004315)1.86917888
78Abnormality of the renal medulla (HP:0100957)1.86498458
79Absent thumb (HP:0009777)1.83459354
80Exertional dyspnea (HP:0002875)1.81750977
81Agitation (HP:0000713)1.81145985
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.80337344
83Late onset (HP:0003584)1.79777645
84Limb dystonia (HP:0002451)1.78442635
85Atonic seizures (HP:0010819)1.78131712
86Distal arthrogryposis (HP:0005684)1.77913798
87Tubulointerstitial nephritis (HP:0001970)1.77834333
88Progressive macrocephaly (HP:0004481)1.76978814
89Impaired vibration sensation in the lower limbs (HP:0002166)1.75956791
90Testicular atrophy (HP:0000029)1.74364503
91Mesangial abnormality (HP:0001966)1.72295849
92Amelogenesis imperfecta (HP:0000705)1.71805869
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71019208
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71019208
95Parakeratosis (HP:0001036)1.70316601
96Polymicrogyria (HP:0002126)1.69116718
97Hepatocellular necrosis (HP:0001404)1.69022575
98IgA deficiency (HP:0002720)1.68682238
99Abnormal glycosylation (HP:0012345)1.67063205
100Abnormal protein N-linked glycosylation (HP:0012347)1.67063205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.16898668
2MST43.49846206
3ZAK3.38797729
4FRK3.33562510
5MAP2K73.30082878
6ACVR1B3.29369689
7NEK13.18226285
8BMPR1B3.16993675
9TLK13.00209345
10ERBB42.66408511
11ADRBK22.40365881
12TSSK62.33258044
13PBK2.04677344
14CASK1.85415674
15GRK11.85365426
16PNCK1.80954119
17TEC1.79469708
18MAP4K21.77276715
19NUAK11.74841926
20BCKDK1.49005920
21PLK31.43334036
22EIF2AK11.41622847
23CSNK1A1L1.41289532
24PINK11.38567367
25CSNK1G31.36301685
26WNK41.35585180
27CSNK1G21.35545953
28PLK21.35043593
29TGFBR11.33587249
30EIF2AK31.32677166
31VRK11.28993537
32TAF11.24615459
33ADRBK11.21573088
34MARK11.16680096
35AKT31.10721283
36CSNK1G11.03964763
37WNK31.00629537
38KIT1.00384796
39MAP3K90.99512134
40GRK50.98933763
41MAPK130.97873799
42BCR0.96828837
43CHEK20.84146493
44MAP3K40.80678315
45DYRK20.78729242
46PDK20.77272527
47PLK40.76254740
48MAP3K120.75227317
49PHKG10.71934953
50PHKG20.71934953
51EIF2AK20.70480273
52MAPK150.67548916
53TRIM280.63017204
54STK160.59904335
55TGFBR20.58628172
56DAPK20.56741021
57INSRR0.55329779
58RPS6KA50.52437419
59WEE10.51551733
60CLK10.50835369
61PAK30.50688547
62PLK10.49967448
63CAMK2A0.49850858
64TTK0.47433012
65PRKCE0.46979609
66IKBKE0.44351591
67STK100.43801218
68TXK0.43187995
69CAMKK20.42845412
70CSNK1A10.42341228
71VRK20.42224502
72PRKCG0.40999499
73CSNK1D0.40623338
74ATM0.39527595
75SGK20.39167740
76DYRK1A0.37706225
77PRKCQ0.35724920
78AURKA0.34111922
79IKBKB0.30941110
80MAP2K60.29706200
81CSF1R0.29186629
82MUSK0.28414874
83CDC70.27656416
84ITK0.26242368
85TYK20.26033259
86MINK10.25570125
87CAMK2D0.25368933
88DMPK0.24615558
89PRKCI0.23389387
90MAPK110.23376699
91PRKACA0.23241893
92ALK0.22432006
93IGF1R0.22091786
94STK38L0.21454244
95MAP3K10.21080218
96SGK10.20900086
97TAOK30.20815084
98EPHA40.20075707
99EPHB10.19328804
100GRK70.18893180

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.35990561
2Steroid biosynthesis_Homo sapiens_hsa001003.21647647
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.79833041
4Proteasome_Homo sapiens_hsa030502.61548193
5Phototransduction_Homo sapiens_hsa047442.56511056
6Propanoate metabolism_Homo sapiens_hsa006402.56463982
7Protein export_Homo sapiens_hsa030602.54148157
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39097883
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38021593
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.31694855
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.30136689
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28157301
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24745859
14Basal transcription factors_Homo sapiens_hsa030222.17763659
15Butanoate metabolism_Homo sapiens_hsa006502.12154760
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05313752
17Fanconi anemia pathway_Homo sapiens_hsa034601.99021181
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90339950
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86471853
20Homologous recombination_Homo sapiens_hsa034401.65762522
21Fatty acid metabolism_Homo sapiens_hsa012121.63654606
22RNA degradation_Homo sapiens_hsa030181.57290611
23Tryptophan metabolism_Homo sapiens_hsa003801.57153204
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56437226
25Oxidative phosphorylation_Homo sapiens_hsa001901.54218026
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53818836
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52838460
28Ether lipid metabolism_Homo sapiens_hsa005651.49234744
29Asthma_Homo sapiens_hsa053101.47100480
30Linoleic acid metabolism_Homo sapiens_hsa005911.41910020
31Circadian rhythm_Homo sapiens_hsa047101.34597534
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34242505
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.26665285
34Peroxisome_Homo sapiens_hsa041461.25355743
35Type I diabetes mellitus_Homo sapiens_hsa049401.21836549
36Parkinsons disease_Homo sapiens_hsa050121.21802956
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21445307
38Caffeine metabolism_Homo sapiens_hsa002321.19888207
39Fatty acid elongation_Homo sapiens_hsa000621.17918698
40Fatty acid degradation_Homo sapiens_hsa000711.15156212
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12441063
42Non-homologous end-joining_Homo sapiens_hsa034501.08020369
43Selenocompound metabolism_Homo sapiens_hsa004501.07470034
44Pyruvate metabolism_Homo sapiens_hsa006201.03190607
45Collecting duct acid secretion_Homo sapiens_hsa049660.99363962
46Allograft rejection_Homo sapiens_hsa053300.98609488
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97554784
48Systemic lupus erythematosus_Homo sapiens_hsa053220.96745210
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91717689
50Mismatch repair_Homo sapiens_hsa034300.91250892
51Nicotine addiction_Homo sapiens_hsa050330.90417926
52One carbon pool by folate_Homo sapiens_hsa006700.89277434
53RNA polymerase_Homo sapiens_hsa030200.83107522
54Autoimmune thyroid disease_Homo sapiens_hsa053200.79840039
55Morphine addiction_Homo sapiens_hsa050320.79778039
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.79343317
57Graft-versus-host disease_Homo sapiens_hsa053320.76941982
58Base excision repair_Homo sapiens_hsa034100.72040421
59Huntingtons disease_Homo sapiens_hsa050160.71509985
60Rheumatoid arthritis_Homo sapiens_hsa053230.71097836
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70620990
62Nucleotide excision repair_Homo sapiens_hsa034200.69567442
63Serotonergic synapse_Homo sapiens_hsa047260.68796043
64Olfactory transduction_Homo sapiens_hsa047400.68053735
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.66932486
66Alzheimers disease_Homo sapiens_hsa050100.66216562
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62173326
68Arachidonic acid metabolism_Homo sapiens_hsa005900.58509845
69Insulin secretion_Homo sapiens_hsa049110.58333159
70Fat digestion and absorption_Homo sapiens_hsa049750.56600116
71Metabolic pathways_Homo sapiens_hsa011000.54068294
72beta-Alanine metabolism_Homo sapiens_hsa004100.53689851
73Nitrogen metabolism_Homo sapiens_hsa009100.53584715
74Purine metabolism_Homo sapiens_hsa002300.51135600
75Regulation of autophagy_Homo sapiens_hsa041400.49008296
76Calcium signaling pathway_Homo sapiens_hsa040200.47041074
77Sulfur metabolism_Homo sapiens_hsa009200.46651394
78Circadian entrainment_Homo sapiens_hsa047130.46084020
79Alcoholism_Homo sapiens_hsa050340.45462607
80Sphingolipid metabolism_Homo sapiens_hsa006000.45220631
81Glutamatergic synapse_Homo sapiens_hsa047240.40420344
82GABAergic synapse_Homo sapiens_hsa047270.39573149
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38152349
84Fructose and mannose metabolism_Homo sapiens_hsa000510.36310871
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34615690
86Taste transduction_Homo sapiens_hsa047420.34474655
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33654887
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33472548
89Ovarian steroidogenesis_Homo sapiens_hsa049130.31684206
90PPAR signaling pathway_Homo sapiens_hsa033200.31453203
91Retinol metabolism_Homo sapiens_hsa008300.29858313
92Pyrimidine metabolism_Homo sapiens_hsa002400.27906931
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.26124965
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24103445
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23037875
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22383859
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22184240
98Mineral absorption_Homo sapiens_hsa049780.21122580
99Antigen processing and presentation_Homo sapiens_hsa046120.20919238
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20856875

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