ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular ketone body metabolic process (GO:0046950)	8.98473246
2	ketone body metabolic process (GO:1902224)	7.96908742
3	adaptation of signaling pathway (GO:0023058)	4.88110226
4	respiratory chain complex IV assembly (GO:0008535)	4.37924654
5	protein neddylation (GO:0045116)	4.35380004
6	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.33161125
7	neuron remodeling (GO:0016322)	4.23157295
8	negative regulation of granulocyte differentiation (GO:0030853)	4.12327831
9	protein complex biogenesis (GO:0070271)	4.00017162
10	positive regulation of T cell differentiation in thymus (GO:0033089)	3.99644687
11	DNA deamination (GO:0045006)	3.94335641
12	nucleobase biosynthetic process (GO:0046112)	3.79660612
13	purine nucleobase biosynthetic process (GO:0009113)	3.75612209
14	forebrain neuron development (GO:0021884)	3.71610860
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.68902627
16	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.63442188
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61510027
18	platelet dense granule organization (GO:0060155)	3.59690310
19	response to xenobiotic stimulus (GO:0009410)	3.58684354
20	negative regulation of macroautophagy (GO:0016242)	3.58424164
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.54962843
22	negative regulation of neurotransmitter secretion (GO:0046929)	3.50337611
23	regulation of pigment cell differentiation (GO:0050932)	3.49249637
24	cytochrome complex assembly (GO:0017004)	3.48063535
25	maternal behavior (GO:0042711)	3.47220059
26	positive regulation of defense response to virus by host (GO:0002230)	3.44321760
27	ribosomal small subunit assembly (GO:0000028)	3.42455246
28	NADH dehydrogenase complex assembly (GO:0010257)	3.41561565
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41561565
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41561565
31	regulation of meiosis I (GO:0060631)	3.39196664
32	parental behavior (GO:0060746)	3.38677041
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38139820
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38139820
35	cobalamin metabolic process (GO:0009235)	3.36667404
36	negative regulation of heart rate (GO:0010459)	3.35966826
37	negative regulation of neurotransmitter transport (GO:0051589)	3.31694624
38	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.23259248
39	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.23259248
40	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.23259248
41	positive regulation of muscle cell apoptotic process (GO:0010661)	3.19427933
42	ubiquinone metabolic process (GO:0006743)	3.19277000
43	lateral ventricle development (GO:0021670)	3.15215449
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.13966177
45	regulation of regulatory T cell differentiation (GO:0045589)	3.12793162
46	negative regulation of appetite (GO:0032099)	3.11334105
47	negative regulation of response to food (GO:0032096)	3.11334105
48	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.09443808
49	mucosal-associated lymphoid tissue development (GO:0048537)	3.07834273
50	Peyers patch development (GO:0048541)	3.07834273
51	forebrain morphogenesis (GO:0048853)	3.07442917
52	negative regulation of response to nutrient levels (GO:0032108)	3.07432808
53	negative regulation of response to extracellular stimulus (GO:0032105)	3.07432808
54	purine nucleotide salvage (GO:0032261)	3.06243987
55	formation of translation preinitiation complex (GO:0001731)	3.02932160
56	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.94883491
57	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.93437266
58	IMP biosynthetic process (GO:0006188)	2.91408474
59	ubiquinone biosynthetic process (GO:0006744)	2.89991595
60	tryptophan metabolic process (GO:0006568)	2.88195178
61	cytidine metabolic process (GO:0046087)	2.87974481
62	cytidine catabolic process (GO:0006216)	2.87974481
63	cytidine deamination (GO:0009972)	2.87974481
64	nephron epithelium morphogenesis (GO:0072088)	2.86164884
65	nephron tubule morphogenesis (GO:0072078)	2.86164884
66	transcytosis (GO:0045056)	2.83718593
67	neuron maturation (GO:0042551)	2.83020151
68	indolalkylamine metabolic process (GO:0006586)	2.81096899
69	homocysteine metabolic process (GO:0050667)	2.79319250
70	behavioral response to nicotine (GO:0035095)	2.78638829
71	protein-cofactor linkage (GO:0018065)	2.78345372
72	positive regulation of vasculogenesis (GO:2001214)	2.75836120
73	central nervous system neuron development (GO:0021954)	2.75598807
74	positive regulation of meiosis (GO:0045836)	2.70695863
75	non-recombinational repair (GO:0000726)	2.67621162
76	double-strand break repair via nonhomologous end joining (GO:0006303)	2.67621162
77	interferon-gamma secretion (GO:0072643)	2.65127592
78	negative regulation of epidermal cell differentiation (GO:0045605)	2.64268754
79	regulation of cilium movement (GO:0003352)	2.63808293
80	L-methionine salvage (GO:0071267)	2.63196335
81	L-methionine biosynthetic process (GO:0071265)	2.63196335
82	amino acid salvage (GO:0043102)	2.63196335
83	UV protection (GO:0009650)	2.61454602
84	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.60328899
85	DNA excision (GO:0044349)	2.60328899
86	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.58718396
87	negative regulation of thymocyte apoptotic process (GO:0070244)	2.57106067
88	postreplication repair (GO:0006301)	2.56579127
89	regulation of female receptivity (GO:0045924)	2.55692037
90	regulation of immunoglobulin secretion (GO:0051023)	2.55567867
91	positive regulation of T cell cytokine production (GO:0002726)	2.54697937
92	fucosylation (GO:0036065)	2.54649548
93	nerve growth factor signaling pathway (GO:0038180)	2.54520795
94	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.53801670
95	terpenoid biosynthetic process (GO:0016114)	2.52259224
96	multicellular organismal reproductive behavior (GO:0033057)	2.51061732
97	positive regulation of meiotic cell cycle (GO:0051446)	2.50896933
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.49068999
99	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.49068999
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.49068999

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.83614119
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.35954260
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.28836825
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.22600315
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87178907
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73618309
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.57464474
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36016906
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34261524
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25388584
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.25230315
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24530078
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23602103
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.11822509
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.05532723
16	VDR_22108803_ChIP-Seq_LS180_Human	2.05380938
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.02173700
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01103155
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.96625917
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88780166
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.88532898
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.87725302
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78630986
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.72383036
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72173306
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.72019895
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70809770
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68058550
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.64168018
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63157217
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.62465195
32	EWS_26573619_Chip-Seq_HEK293_Human	1.62253225
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61000816
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.60782434
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57819631
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.56055989
37	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.55006062
38	P300_19829295_ChIP-Seq_ESCs_Human	1.52222950
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.52178372
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50156063
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47832037
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47832037
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47133355
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47133355
45	FUS_26573619_Chip-Seq_HEK293_Human	1.46347847
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46247795
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43023272
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34692973
49	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34286698
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30267727
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29010495
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.27866500
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27112473
54	NCOR_22424771_ChIP-Seq_293T_Human	1.26249297
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.25982311
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23096421
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.23096421
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23032069
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21418468
60	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20844604
61	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20077649
62	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.19438341
63	AR_20517297_ChIP-Seq_VCAP_Human	1.18862291
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18375077
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17186815
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16402361
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16292655
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14993511
69	EZH2_22144423_ChIP-Seq_EOC_Human	1.14722136
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12202645
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10231295
72	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09422089
73	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07458108
74	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.07387360
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07173811
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05731251
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05115579
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04620568
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04418568
80	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03654546
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03611911
82	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02916017
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02725361
84	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.01660769
85	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01530189
86	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01264377
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00964567
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00305887
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99509409
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98521646
91	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.97790670
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97260624
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.96178695
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95508707
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95270921
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94741742
97	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.94123447
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93776319
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.91919683
100	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.91917050

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.98194763
2	MP0001188_hyperpigmentation	5.46538493
3	MP0000372_irregular_coat_pigmentation	3.40050415
4	MP0004043_abnormal_pH_regulation	3.26107696
5	MP0003646_muscle_fatigue	2.98074962
6	MP0002163_abnormal_gland_morphology	2.89976645
7	MP0001529_abnormal_vocalization	2.18581940
8	MP0006276_abnormal_autonomic_nervous	2.08897105
9	MP0005409_darkened_coat_color	1.95903955
10	MP0001764_abnormal_homeostasis	1.89641089
11	MP0005174_abnormal_tail_pigmentation	1.88102468
12	MP0001485_abnormal_pinna_reflex	1.81196083
13	MP0003806_abnormal_nucleotide_metabolis	1.78890168
14	MP0000015_abnormal_ear_pigmentation	1.75741521
15	MP0004142_abnormal_muscle_tone	1.74186022
16	MP0005075_abnormal_melanosome_morpholog	1.73159731
17	MP0004147_increased_porphyrin_level	1.71578249
18	MP0003119_abnormal_digestive_system	1.66396272
19	MP0003724_increased_susceptibility_to	1.65527672
20	MP0005464_abnormal_platelet_physiology	1.65081367
21	MP0005645_abnormal_hypothalamus_physiol	1.61738446
22	MP0003011_delayed_dark_adaptation	1.55949048
23	MP0001501_abnormal_sleep_pattern	1.52463423
24	MP0005551_abnormal_eye_electrophysiolog	1.51529642
25	MP0008058_abnormal_DNA_repair	1.51425918
26	MP0008872_abnormal_physiological_respon	1.51337385
27	MP0005379_endocrine/exocrine_gland_phen	1.47235282
28	MP0006036_abnormal_mitochondrial_physio	1.46094860
29	MP0002277_abnormal_respiratory_mucosa	1.42142007
30	MP0004885_abnormal_endolymph	1.41591166
31	MP0009785_altered_susceptibility_to	1.41199383
32	MP0002138_abnormal_hepatobiliary_system	1.35908183
33	MP0001919_abnormal_reproductive_system	1.31933870
34	MP0008789_abnormal_olfactory_epithelium	1.27469849
35	MP0003786_premature_aging	1.26693153
36	MP0002102_abnormal_ear_morphology	1.26010219
37	MP0006072_abnormal_retinal_apoptosis	1.22836943
38	MP0002234_abnormal_pharynx_morphology	1.18448427
39	MP0005253_abnormal_eye_physiology	1.16839803
40	MP0003195_calcinosis	1.15160511
41	MP0009697_abnormal_copulation	1.14912489
42	MP0001968_abnormal_touch/_nociception	1.13406993
43	MP0002837_dystrophic_cardiac_calcinosis	1.12658084
44	MP0002095_abnormal_skin_pigmentation	1.12330625
45	MP0002557_abnormal_social/conspecific_i	1.11349761
46	MP0001984_abnormal_olfaction	1.10069901
47	MP0008877_abnormal_DNA_methylation	1.07570919
48	MP0005389_reproductive_system_phenotype	1.07554720
49	MP0001664_abnormal_digestion	1.07342133
50	MP0001835_abnormal_antigen_presentation	1.07094471
51	MP0005084_abnormal_gallbladder_morpholo	1.06557104
52	MP0002272_abnormal_nervous_system	1.06325676
53	MP0002184_abnormal_innervation	1.05759939
54	MP0003567_abnormal_fetal_cardiomyocyte	1.05543387
55	MP0005503_abnormal_tendon_morphology	1.04310009
56	MP0005499_abnormal_olfactory_system	1.03814983
57	MP0005394_taste/olfaction_phenotype	1.03814983
58	MP0003183_abnormal_peptide_metabolism	1.03720285
59	MP0008875_abnormal_xenobiotic_pharmacok	1.02271447
60	MP0002148_abnormal_hypersensitivity_rea	1.01890059
61	MP0006035_abnormal_mitochondrial_morpho	0.97737146
62	MP0002736_abnormal_nociception_after	0.97697616
63	MP0005220_abnormal_exocrine_pancreas	0.97362212
64	MP0003718_maternal_effect	0.95285076
65	MP0010386_abnormal_urinary_bladder	0.94764291
66	MP0001191_abnormal_skin_condition	0.91771583
67	MP0001905_abnormal_dopamine_level	0.89964908
68	MP0009745_abnormal_behavioral_response	0.83962114
69	MP0005646_abnormal_pituitary_gland	0.82834368
70	MP0004145_abnormal_muscle_electrophysio	0.81293828
71	MP0000230_abnormal_systemic_arterial	0.80624359
72	MP0005195_abnormal_posterior_eye	0.79221608
73	MP0000631_abnormal_neuroendocrine_gland	0.78333838
74	MP0003936_abnormal_reproductive_system	0.77794268
75	MP0005167_abnormal_blood-brain_barrier	0.77641353
76	MP0001873_stomach_inflammation	0.77014066
77	MP0000613_abnormal_salivary_gland	0.76636615
78	MP0003880_abnormal_central_pattern	0.72947657
79	MP0008995_early_reproductive_senescence	0.72146205
80	MP0003186_abnormal_redox_activity	0.71480711
81	MP0001727_abnormal_embryo_implantation	0.70212348
82	MP0002177_abnormal_outer_ear	0.69855910
83	MP0000685_abnormal_immune_system	0.69081087
84	MP0002876_abnormal_thyroid_physiology	0.68760828
85	MP0006292_abnormal_olfactory_placode	0.67697765
86	MP0000371_diluted_coat_color	0.67478250
87	MP0001963_abnormal_hearing_physiology	0.64265960
88	MP0001293_anophthalmia	0.64101803
89	MP0005332_abnormal_amino_acid	0.63846657
90	MP0004484_altered_response_of	0.63674779
91	MP0003635_abnormal_synaptic_transmissio	0.62703284
92	MP0002160_abnormal_reproductive_system	0.61424151
93	MP0003866_abnormal_defecation	0.60368749
94	MP0002075_abnormal_coat/hair_pigmentati	0.60003346
95	MP0000427_abnormal_hair_cycle	0.59229196
96	MP0002210_abnormal_sex_determination	0.58904398
97	MP0001348_abnormal_lacrimal_gland	0.58560713
98	MP0004782_abnormal_surfactant_physiolog	0.58105910
99	MP0005085_abnormal_gallbladder_physiolo	0.56480039
100	MP0001970_abnormal_pain_threshold	0.55452500

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Methylmalonic acidemia (HP:0002912)	5.67428582
2	Ketoacidosis (HP:0001993)	5.64150886
3	Increased hepatocellular lipid droplets (HP:0006565)	4.49492706
4	Delayed CNS myelination (HP:0002188)	4.37084456
5	Lipid accumulation in hepatocytes (HP:0006561)	4.28882825
6	Ketosis (HP:0001946)	4.14935465
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.90345990
8	Methylmalonic aciduria (HP:0012120)	3.89124115
9	Renal Fanconi syndrome (HP:0001994)	3.75414432
10	Abnormality of vitamin B metabolism (HP:0004340)	3.74013831
11	Hyperglycinemia (HP:0002154)	3.61955373
12	Metaphyseal dysplasia (HP:0100255)	3.58656383
13	Prominent metopic ridge (HP:0005487)	3.58378121
14	Congenital, generalized hypertrichosis (HP:0004540)	3.55294028
15	Mitochondrial inheritance (HP:0001427)	3.37431927
16	Abnormality of DNA repair (HP:0003254)	3.37114251
17	Acute necrotizing encephalopathy (HP:0006965)	3.36840876
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.28382528
19	Increased CSF lactate (HP:0002490)	3.24569701
20	Abnormality of the metopic suture (HP:0005556)	3.21688721
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.16373672
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.16373672
23	Exertional dyspnea (HP:0002875)	3.12101849
24	3-Methylglutaconic aciduria (HP:0003535)	3.12001246
25	Tachypnea (HP:0002789)	3.11189802
26	Increased intramyocellular lipid droplets (HP:0012240)	3.08493190
27	Hypothermia (HP:0002045)	3.01423822
28	Dicarboxylic aciduria (HP:0003215)	3.00702790
29	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.00702790
30	Acute encephalopathy (HP:0006846)	2.99468331
31	Facial hemangioma (HP:0000329)	2.91516708
32	Tubulointerstitial nephritis (HP:0001970)	2.91054742
33	Conjunctival telangiectasia (HP:0000524)	2.90156164
34	Progressive macrocephaly (HP:0004481)	2.88192031
35	Severe combined immunodeficiency (HP:0004430)	2.86910475
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79504021
37	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.74010828
38	Hepatic necrosis (HP:0002605)	2.73866220
39	Hepatocellular necrosis (HP:0001404)	2.61314081
40	Increased muscle lipid content (HP:0009058)	2.60991712
41	Thyroiditis (HP:0100646)	2.54541295
42	Glycosuria (HP:0003076)	2.52591744
43	Abnormality of urine glucose concentration (HP:0011016)	2.52591744
44	Congenital stationary night blindness (HP:0007642)	2.52161323
45	Skin nodule (HP:0200036)	2.52108468
46	Abnormality of vitamin metabolism (HP:0100508)	2.46923991
47	Adactyly (HP:0009776)	2.45293935
48	Delayed myelination (HP:0012448)	2.41194079
49	Pancreatic cysts (HP:0001737)	2.37955253
50	Agitation (HP:0000713)	2.31026759
51	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.29667036
52	Respiratory difficulties (HP:0002880)	2.29053004
53	Megaloblastic anemia (HP:0001889)	2.29043551
54	Abnormality of renal resorption (HP:0011038)	2.28992614
55	Generalized aminoaciduria (HP:0002909)	2.28938013
56	Fibular aplasia (HP:0002990)	2.18707153
57	Abnormal protein glycosylation (HP:0012346)	2.18138935
58	Abnormal glycosylation (HP:0012345)	2.18138935
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.18138935
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.18138935
61	Abnormality of serine family amino acid metabolism (HP:0010894)	2.17135307
62	Abnormality of glycine metabolism (HP:0010895)	2.17135307
63	Posterior subcapsular cataract (HP:0007787)	2.16432284
64	CNS hypomyelination (HP:0003429)	2.13978884
65	Cerebral edema (HP:0002181)	2.11266637
66	Choroideremia (HP:0001139)	2.11018942
67	Pancreatic islet-cell hyperplasia (HP:0004510)	2.08717947
68	Medial flaring of the eyebrow (HP:0010747)	2.07539679
69	Abnormality of the renal cortex (HP:0011035)	2.05134301
70	Hyperphosphaturia (HP:0003109)	2.05093566
71	Combined immunodeficiency (HP:0005387)	2.02531976
72	Dry hair (HP:0011359)	2.02149822
73	Mesangial abnormality (HP:0001966)	1.97538883
74	Pendular nystagmus (HP:0012043)	1.95807889
75	Increased serum lactate (HP:0002151)	1.93841680
76	Retinal atrophy (HP:0001105)	1.92530479
77	Renal cortical cysts (HP:0000803)	1.91203783
78	Abolished electroretinogram (ERG) (HP:0000550)	1.90909069
79	Testicular atrophy (HP:0000029)	1.89649565
80	Abnormality of B cell number (HP:0010975)	1.88301548
81	Hypoglycemic coma (HP:0001325)	1.87434546
82	Lethargy (HP:0001254)	1.87413245
83	Entropion (HP:0000621)	1.87229908
84	Disproportionate short-trunk short stature (HP:0003521)	1.85947478
85	B lymphocytopenia (HP:0010976)	1.85574218
86	Carpal bone hypoplasia (HP:0001498)	1.82751195
87	Gait imbalance (HP:0002141)	1.81578392
88	Neoplasm of the adrenal cortex (HP:0100641)	1.81537989
89	Hypsarrhythmia (HP:0002521)	1.81392623
90	Nephronophthisis (HP:0000090)	1.81298613
91	Abnormality of serum amino acid levels (HP:0003112)	1.80416120
92	Spastic paraparesis (HP:0002313)	1.79977160
93	Optic disc pallor (HP:0000543)	1.76921188
94	Progressive inability to walk (HP:0002505)	1.74641053
95	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.72364223
96	EEG with generalized epileptiform discharges (HP:0011198)	1.70162429
97	Homocystinuria (HP:0002156)	1.70112036
98	Abnormality of homocysteine metabolism (HP:0010919)	1.70112036
99	Nephrogenic diabetes insipidus (HP:0009806)	1.69922199
100	Anorexia (HP:0002039)	1.69423183

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.78257763
2	VRK2	3.03362867
3	TXK	2.95033889
4	FRK	2.85097456
5	TAF1	2.53293904
6	TNIK	2.47615875
7	TLK1	2.36690969
8	MST4	2.27245671
9	AKT3	2.24632557
10	ZAK	2.22699094
11	GRK1	2.19556266
12	STK16	2.17421136
13	SRPK1	2.08337287
14	TRIM28	2.00163627
15	ADRBK2	1.98676839
16	CSNK1A1L	1.91820214
17	CSNK1G3	1.83038181
18	TIE1	1.77379938
19	MAP4K2	1.74752028
20	EPHA3	1.73696418
21	CSNK1G2	1.65693218
22	DYRK2	1.59624591
23	TSSK6	1.53372281
24	CSNK1G1	1.48706274
25	MAP2K6	1.36805708
26	MARK1	1.36054633
27	ACVR1B	1.35494344
28	PINK1	1.35422760
29	CDK8	1.24576773
30	SIK3	1.21511118
31	VRK1	1.16782871
32	EIF2AK3	1.16204517
33	PIK3CA	1.12409313
34	MAP3K6	1.10009205
35	MAPK13	1.09942460
36	BCR	1.06614552
37	PHKG1	1.04194769
38	PHKG2	1.04194769
39	ALK	1.01353421
40	MAP3K11	1.00129222
41	WNK3	0.95990016
42	MAPKAPK5	0.90408504
43	NUAK1	0.89573553
44	PASK	0.89048410
45	PBK	0.88669736
46	BMPR2	0.88480454
47	MAP3K12	0.88453562
48	NLK	0.84172641
49	PLK3	0.83497176
50	TEC	0.80974189
51	BMPR1B	0.78485068
52	ADRBK1	0.78195279
53	INSRR	0.78100660
54	GRK7	0.78073255
55	FES	0.76939213
56	CLK1	0.76400235
57	KIT	0.75566449
58	ITK	0.74642294
59	BCKDK	0.74629234
60	GRK5	0.74285952
61	CDK9	0.72837490
62	MINK1	0.71760841
63	TGFBR1	0.71501246
64	RIPK4	0.69577007
65	MKNK2	0.69371903
66	PLK2	0.67342407
67	FER	0.66837678
68	SCYL2	0.64387061
69	CASK	0.63456181
70	OXSR1	0.62302361
71	MAPKAPK3	0.61537820
72	PRKCG	0.60504804
73	EIF2AK2	0.60484331
74	PRKCE	0.56669979
75	CSNK1E	0.55239293
76	CAMK2A	0.55018039
77	AURKA	0.51097600
78	STK39	0.49838011
79	DAPK1	0.49705470
80	CSNK1A1	0.49178260
81	SYK	0.43183129
82	PAK3	0.43078975
83	FLT3	0.43052767
84	STK11	0.42822245
85	BTK	0.41418559
86	PIK3CG	0.40736576
87	RPS6KB2	0.40081946
88	ABL2	0.39963476
89	RPS6KA6	0.39749826
90	EIF2AK1	0.39607199
91	CSNK2A2	0.39277453
92	HIPK2	0.38038594
93	DAPK2	0.38029658
94	PRKACA	0.38004006
95	DAPK3	0.37988134
96	MAP2K4	0.37899742
97	NEK1	0.34801281
98	TNK2	0.34678350
99	WNK4	0.34097709
100	CSNK2A1	0.33463528

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.84977393
2	Proteasome_Homo sapiens_hsa03050	3.53709333
3	Butanoate metabolism_Homo sapiens_hsa00650	2.88043262
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.85378017
5	Protein export_Homo sapiens_hsa03060	2.77170529
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68486450
7	Nucleotide excision repair_Homo sapiens_hsa03420	2.59916176
8	Asthma_Homo sapiens_hsa05310	2.31323875
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18372906
10	Parkinsons disease_Homo sapiens_hsa05012	1.92283240
11	Ribosome_Homo sapiens_hsa03010	1.89662185
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67163541
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.65974418
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65483478
15	Huntingtons disease_Homo sapiens_hsa05016	1.59149560
16	Alzheimers disease_Homo sapiens_hsa05010	1.56353517
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51106388
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.46849556
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46764744
20	Allograft rejection_Homo sapiens_hsa05330	1.44405066
21	Mismatch repair_Homo sapiens_hsa03430	1.41118444
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40069786
23	Propanoate metabolism_Homo sapiens_hsa00640	1.39182997
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.32341805
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29511007
26	Basal transcription factors_Homo sapiens_hsa03022	1.26577739
27	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.24361607
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16701516
29	RNA degradation_Homo sapiens_hsa03018	1.14490928
30	Salivary secretion_Homo sapiens_hsa04970	1.13602002
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12050382
32	Phototransduction_Homo sapiens_hsa04744	1.11092005
33	Homologous recombination_Homo sapiens_hsa03440	1.11040403
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10676074
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08221028
36	One carbon pool by folate_Homo sapiens_hsa00670	1.07021018
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04197988
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03384054
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00992901
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00713681
41	Regulation of autophagy_Homo sapiens_hsa04140	0.95910091
42	Circadian entrainment_Homo sapiens_hsa04713	0.95466856
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94191982
44	Long-term depression_Homo sapiens_hsa04730	0.93086950
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.89377570
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89289618
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88561695
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.85531130
49	African trypanosomiasis_Homo sapiens_hsa05143	0.84599002
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83965904
51	Nicotine addiction_Homo sapiens_hsa05033	0.82727619
52	RNA transport_Homo sapiens_hsa03013	0.80953735
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79953030
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75522457
55	Olfactory transduction_Homo sapiens_hsa04740	0.75421320
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72987840
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.67937997
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65295388
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.65092505
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.65037563
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.61123291
62	Cholinergic synapse_Homo sapiens_hsa04725	0.60846269
63	RNA polymerase_Homo sapiens_hsa03020	0.60697488
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.60245826
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59761151
66	Renin secretion_Homo sapiens_hsa04924	0.58227045
67	Insulin secretion_Homo sapiens_hsa04911	0.57364774
68	Morphine addiction_Homo sapiens_hsa05032	0.57009269
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56624231
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56438187
71	Pancreatic secretion_Homo sapiens_hsa04972	0.56116455
72	Serotonergic synapse_Homo sapiens_hsa04726	0.54710353
73	Retinol metabolism_Homo sapiens_hsa00830	0.54707342
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.52023574
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51623836
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51516340
77	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51493906
78	Metabolic pathways_Homo sapiens_hsa01100	0.50220721
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49614642
80	Purine metabolism_Homo sapiens_hsa00230	0.48011715
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46047811
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44966195
83	Caffeine metabolism_Homo sapiens_hsa00232	0.44628743
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42173243
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41927759
86	Peroxisome_Homo sapiens_hsa04146	0.41903483
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.41828098
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41225284
89	Sulfur metabolism_Homo sapiens_hsa00920	0.39638353
90	Long-term potentiation_Homo sapiens_hsa04720	0.38302579
91	Viral myocarditis_Homo sapiens_hsa05416	0.37719597
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37716059
93	ABC transporters_Homo sapiens_hsa02010	0.37587019
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.36395299
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34027561
96	Taste transduction_Homo sapiens_hsa04742	0.32327552
97	Base excision repair_Homo sapiens_hsa03410	0.31670758
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30746010
99	DNA replication_Homo sapiens_hsa03030	0.29861675
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29328476

FDPSP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »