FDPSP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.31445480
2T cell migration (GO:0072678)4.16213919
3positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.03886795
4positive regulation of tolerance induction (GO:0002645)4.03229073
5interferon-gamma production (GO:0032609)4.02723478
6DNA deamination (GO:0045006)3.97446242
7immunoglobulin mediated immune response (GO:0016064)3.97153181
8regulation of interleukin-12 biosynthetic process (GO:0045075)3.88298920
9positive T cell selection (GO:0043368)3.83869380
10detection of molecule of bacterial origin (GO:0032490)3.66050736
11regulation of interferon-beta biosynthetic process (GO:0045357)3.63540360
12cytidine metabolic process (GO:0046087)3.61180441
13cytidine catabolic process (GO:0006216)3.61180441
14cytidine deamination (GO:0009972)3.61180441
15negative T cell selection (GO:0043383)3.53319819
16regulation of T cell tolerance induction (GO:0002664)3.51183707
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50402981
18negative regulation of viral genome replication (GO:0045071)3.49805038
19response to type I interferon (GO:0034340)3.46129195
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44474667
21positive regulation of defense response to virus by host (GO:0002230)3.35766350
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.35642340
23type I interferon signaling pathway (GO:0060337)3.34427682
24cellular response to type I interferon (GO:0071357)3.34427682
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32925870
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31757288
27regulation of gamma-delta T cell activation (GO:0046643)3.30994208
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24451261
29leukocyte aggregation (GO:0070486)3.23364722
30neutrophil mediated immunity (GO:0002446)3.23228571
31positive thymic T cell selection (GO:0045059)3.22346499
32regulation of tolerance induction (GO:0002643)3.22230802
33positive regulation of interleukin-1 beta secretion (GO:0050718)3.19433032
34negative thymic T cell selection (GO:0045060)3.19336150
35actin nucleation (GO:0045010)3.12421623
36negative regulation of T cell apoptotic process (GO:0070233)3.09268742
37regulation of interferon-alpha production (GO:0032647)3.08618375
38detection of other organism (GO:0098543)3.08227519
39positive regulation of B cell differentiation (GO:0045579)3.06987076
40negative regulation of interleukin-12 production (GO:0032695)3.06765371
41T cell selection (GO:0045058)3.06063206
42positive regulation of interleukin-1 secretion (GO:0050716)3.05997056
43positive regulation of antigen processing and presentation (GO:0002579)3.02884854
44negative regulation of execution phase of apoptosis (GO:1900118)3.01932089
45B cell mediated immunity (GO:0019724)2.99922848
46regulation of gamma-delta T cell differentiation (GO:0045586)2.99607665
47T-helper 1 type immune response (GO:0042088)2.95226589
48cellular response to ethanol (GO:0071361)2.94871766
49pyrimidine ribonucleoside catabolic process (GO:0046133)2.94558916
50myeloid leukocyte mediated immunity (GO:0002444)2.94313515
51regulation of antigen processing and presentation (GO:0002577)2.92968648
52germinal center formation (GO:0002467)2.92475531
53positive regulation of interleukin-2 production (GO:0032743)2.91020201
54positive regulation of interleukin-1 production (GO:0032732)2.89761943
55regulation of vitamin D biosynthetic process (GO:0060556)2.89455736
56thymic T cell selection (GO:0045061)2.88567692
57regulation of interleukin-1 beta secretion (GO:0050706)2.87960981
58positive regulation of interferon-alpha production (GO:0032727)2.87692107
59detection of external biotic stimulus (GO:0098581)2.86668029
60macrophage activation involved in immune response (GO:0002281)2.86574013
61positive regulation of granulocyte differentiation (GO:0030854)2.83951733
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79560517
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.79560517
64modulation by symbiont of host immune response (GO:0052553)2.79560517
65positive regulation by symbiont of host defense response (GO:0052509)2.79560517
66modulation by symbiont of host defense response (GO:0052031)2.79560517
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79560517
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78973683
69production of molecular mediator involved in inflammatory response (GO:0002532)2.78069769
70regulation of B cell differentiation (GO:0045577)2.76571084
71defense response to virus (GO:0051607)2.76562832
72positive regulation of interleukin-1 beta production (GO:0032731)2.76194616
73regulation of defense response to virus by host (GO:0050691)2.75852658
74response to interferon-alpha (GO:0035455)2.75625619
75cellular response to exogenous dsRNA (GO:0071360)2.73049435
76lymphocyte chemotaxis (GO:0048247)2.72526321
77defense response to protozoan (GO:0042832)2.72062484
78positive regulation of B cell proliferation (GO:0030890)2.71989043
79regulation of B cell receptor signaling pathway (GO:0050855)2.71514175
80response to peptidoglycan (GO:0032494)2.70249316
81neutrophil activation involved in immune response (GO:0002283)2.69721716
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68800356
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67183261
84microglial cell activation (GO:0001774)2.66970931
85positive regulation of developmental pigmentation (GO:0048087)2.66848733
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66584992
87interferon-gamma-mediated signaling pathway (GO:0060333)2.66523896
88antigen processing and presentation of endogenous antigen (GO:0019883)2.65343770
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.65257185
90regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.64538544
91regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.64538544
92interferon-gamma secretion (GO:0072643)2.62717443
93cellular response to interleukin-15 (GO:0071350)2.61419041
94negative regulation of defense response to virus (GO:0050687)2.60815437
95establishment of protein localization to Golgi (GO:0072600)2.60088576
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59610304
97negative regulation of cell killing (GO:0031342)2.59610304
98regulation of viral genome replication (GO:0045069)2.58247725
99amine catabolic process (GO:0009310)2.55247987
100cellular biogenic amine catabolic process (GO:0042402)2.55247987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.50681092
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.86547277
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71352013
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.23580964
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.06647761
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05427522
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79860734
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.48845049
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76996951
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65309953
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.63495672
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43210882
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27107422
14RUNX_20019798_ChIP-Seq_JUKART_Human2.25079553
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02613781
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99660706
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96692895
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96659010
19VDR_24787735_ChIP-Seq_THP-1_Human1.96551366
20MYB_26560356_Chip-Seq_TH2_Human1.95303368
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.88458718
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82844198
23ER_23166858_ChIP-Seq_MCF-7_Human1.82237141
24GATA3_27048872_Chip-Seq_THYMUS_Human1.78325481
25GATA3_26560356_Chip-Seq_TH2_Human1.71355318
26MYB_26560356_Chip-Seq_TH1_Human1.65014912
27SPI1_23547873_ChIP-Seq_NB4_Human1.58717215
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53776085
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48548278
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48450789
31SPI1_23127762_ChIP-Seq_K562_Human1.48144945
32IGF1R_20145208_ChIP-Seq_DFB_Human1.47832421
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.46807470
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44512938
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43316045
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39562341
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39486389
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39047945
39ZNF274_21170338_ChIP-Seq_K562_Hela1.36107880
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32332062
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31951986
42SCL_19346495_ChIP-Seq_HPC-7_Human1.31365883
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29418540
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26673008
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24209212
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19554367
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19342023
48GBX2_23144817_ChIP-Seq_PC3_Human1.18689897
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16667572
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15161926
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09131789
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.08080456
53VDR_22108803_ChIP-Seq_LS180_Human1.07305598
54RXR_22108803_ChIP-Seq_LS180_Human1.06238986
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02919793
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01780536
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01698845
58SMRT_27268052_Chip-Seq_Bcells_Human1.00687974
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00351930
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00232823
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98953031
62POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98482039
63PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96995779
64CJUN_26792858_Chip-Seq_BT549_Human0.95881740
65ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95666970
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95341663
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95245729
68SALL1_21062744_ChIP-ChIP_HESCs_Human0.93927160
69MAF_26560356_Chip-Seq_TH1_Human0.93907999
70STAT1_20625510_ChIP-Seq_HELA_Human0.92809668
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92633550
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91063114
73AHR_22903824_ChIP-Seq_MCF-7_Human0.89960766
74CDX2_22108803_ChIP-Seq_LS180_Human0.89308733
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.88840251
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88466247
77CBP_20019798_ChIP-Seq_JUKART_Human0.88466247
78GATA2_19941826_ChIP-Seq_K562_Human0.87841669
79GATA3_26560356_Chip-Seq_TH1_Human0.87325688
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.87250606
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.86867340
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86755256
83GATA1_22025678_ChIP-Seq_K562_Human0.83702119
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.83639105
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82894317
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82831796
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82792630
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82124555
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82063445
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81548120
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81029104
92BCAT_22108803_ChIP-Seq_LS180_Human0.80657953
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79891621
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.79140186
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78574236
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.77251955
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76900410
98TCF4_23295773_ChIP-Seq_U87_Human0.76223698
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76143338
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76101589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.05680860
2MP0001835_abnormal_antigen_presentation4.06939354
3MP0003724_increased_susceptibility_to3.55471181
4MP0006054_spinal_hemorrhage3.36918231
5MP0005671_abnormal_response_to3.22683369
6MP0009785_altered_susceptibility_to2.97660598
7MP0000015_abnormal_ear_pigmentation2.68127384
8MP0006082_CNS_inflammation2.50978270
9MP0005174_abnormal_tail_pigmentation2.50147054
10MP0002148_abnormal_hypersensitivity_rea2.47406736
11MP0004381_abnormal_hair_follicle2.45804581
12MP0001800_abnormal_humoral_immune2.44874902
13MP0005387_immune_system_phenotype2.33183210
14MP0001790_abnormal_immune_system2.33183210
15MP0009764_decreased_sensitivity_to2.31914316
16MP0005000_abnormal_immune_tolerance2.29767555
17MP0002419_abnormal_innate_immunity2.29480606
18MP0005025_abnormal_response_to2.29029590
19MP0002452_abnormal_antigen_presenting2.16899727
20MP0002723_abnormal_immune_serum2.16811467
21MP0003136_yellow_coat_color2.16188187
22MP0002420_abnormal_adaptive_immunity2.04407215
23MP0003172_abnormal_lysosome_physiology2.02360916
24MP0003763_abnormal_thymus_physiology2.02224624
25MP0001819_abnormal_immune_cell2.00182750
26MP0000685_abnormal_immune_system1.98158906
27MP0003436_decreased_susceptibility_to1.96882217
28MP0002332_abnormal_exercise_endurance1.91440548
29MP0002405_respiratory_system_inflammati1.86364098
30MP0004947_skin_inflammation1.75859814
31MP0003045_fibrosis1.72660334
32MP0003303_peritoneal_inflammation1.71258541
33MP0005310_abnormal_salivary_gland1.69971960
34MP0002138_abnormal_hepatobiliary_system1.64579932
35MP0003195_calcinosis1.51597280
36MP0000716_abnormal_immune_system1.47689984
37MP0002095_abnormal_skin_pigmentation1.46939239
38MP0001845_abnormal_inflammatory_respons1.41126569
39MP0000689_abnormal_spleen_morphology1.40707037
40MP0003950_abnormal_plasma_membrane1.40322062
41MP0002166_altered_tumor_susceptibility1.36961332
42MP0010155_abnormal_intestine_physiology1.35963088
43MP0002398_abnormal_bone_marrow1.34696326
44MP0003448_altered_tumor_morphology1.34392714
45MP0008260_abnormal_autophagy1.33167271
46MP0002722_abnormal_immune_system1.30336401
47MP0001485_abnormal_pinna_reflex1.28738322
48MP0002736_abnormal_nociception_after1.24717323
49MP0003866_abnormal_defecation1.24115531
50MP0008004_abnormal_stomach_pH1.23939716
51MP0005083_abnormal_biliary_tract1.23701829
52MP0001533_abnormal_skeleton_physiology1.20992436
53MP0005409_darkened_coat_color1.19000374
54MP0003690_abnormal_glial_cell1.14699779
55MP0008469_abnormal_protein_level1.12192456
56MP0000858_altered_metastatic_potential1.10660577
57MP0003075_altered_response_to1.09189362
58MP0000703_abnormal_thymus_morphology1.07608039
59MP0005464_abnormal_platelet_physiology1.06288278
60MP0002429_abnormal_blood_cell1.05756532
61MP0003656_abnormal_erythrocyte_physiolo1.04088231
62MP0001853_heart_inflammation1.03701561
63MP0005166_decreased_susceptibility_to1.01464808
64MP0009763_increased_sensitivity_to1.00874756
65MP0003183_abnormal_peptide_metabolism0.99097137
66MP0000371_diluted_coat_color0.97181560
67MP0002006_tumorigenesis0.96836352
68MP0002168_other_aberrant_phenotype0.96365075
69MP0009840_abnormal_foam_cell0.93051100
70MP0004510_myositis0.92058885
71MP0004883_abnormal_blood_vessel0.88797315
72MP0000427_abnormal_hair_cycle0.88533844
73MP0009765_abnormal_xenobiotic_induced0.87345578
74MP0009333_abnormal_splenocyte_physiolog0.86603570
75MP0001968_abnormal_touch/_nociception0.85019829
76MP0000343_altered_response_to0.84702637
77MP0002998_abnormal_bone_remodeling0.83647700
78MP0004808_abnormal_hematopoietic_stem0.82263040
79MP0001545_abnormal_hematopoietic_system0.80773953
80MP0005397_hematopoietic_system_phenotyp0.80773953
81MP0005266_abnormal_metabolism0.78170603
82MP0005451_abnormal_body_composition0.77340374
83MP0001188_hyperpigmentation0.74562221
84MP0005075_abnormal_melanosome_morpholog0.73335078
85MP0003453_abnormal_keratinocyte_physiol0.73261067
86MP0005164_abnormal_response_to0.72484152
87MP0000465_gastrointestinal_hemorrhage0.71532562
88MP0002396_abnormal_hematopoietic_system0.69547819
89MP0005058_abnormal_lysosome_morphology0.68950347
90MP0004130_abnormal_muscle_cell0.68691461
91MP0005367_renal/urinary_system_phenotyp0.67965009
92MP0000516_abnormal_urinary_system0.67965009
93MP0003806_abnormal_nucleotide_metabolis0.67073775
94MP0003646_muscle_fatigue0.66124701
95MP0003091_abnormal_cell_migration0.66091119
96MP0002019_abnormal_tumor_incidence0.65876918
97MP0003300_gastrointestinal_ulcer0.65803786
98MP0000383_abnormal_hair_follicle0.64010471
99MP0001851_eye_inflammation0.63771822
100MP0001986_abnormal_taste_sensitivity0.63321876

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.12824681
2Abnormality of T cell number (HP:0011839)4.84003825
3Recurrent bacterial skin infections (HP:0005406)4.14670344
4Retrobulbar optic neuritis (HP:0100654)4.12519230
5Optic neuritis (HP:0100653)4.12519230
6Autoimmune hemolytic anemia (HP:0001890)3.83583268
7Elevated erythrocyte sedimentation rate (HP:0003565)3.81650517
8Orchitis (HP:0100796)3.62964123
9Severe combined immunodeficiency (HP:0004430)3.56775642
10Thyroiditis (HP:0100646)3.55087241
11Recurrent gram-negative bacterial infections (HP:0005420)3.50899271
12Stomatitis (HP:0010280)3.47528697
13Myositis (HP:0100614)3.41569807
14Hypoproteinemia (HP:0003075)3.39355538
15Recurrent abscess formation (HP:0002722)3.38783471
16Increased IgM level (HP:0003496)3.35070593
17Abnormality of macrophages (HP:0004311)3.31293737
18Recurrent fungal infections (HP:0002841)3.25597545
19Abnormality of eosinophils (HP:0001879)3.23421642
20Prostate neoplasm (HP:0100787)3.14319935
21Pustule (HP:0200039)3.13138118
22Recurrent viral infections (HP:0004429)3.10169280
23Eosinophilia (HP:0001880)3.06116667
24Autoimmune thrombocytopenia (HP:0001973)2.97025756
25Combined immunodeficiency (HP:0005387)2.94815590
26Leukocytosis (HP:0001974)2.93784940
27Abnormality of T cells (HP:0002843)2.90801813
28IgG deficiency (HP:0004315)2.81535505
29Abnormality of glycolipid metabolism (HP:0010969)2.79554270
30Abnormality of liposaccharide metabolism (HP:0010968)2.79554270
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.79554270
32Recurrent skin infections (HP:0001581)2.69207614
33Abnormality of B cell number (HP:0010975)2.65190807
34Lymphopenia (HP:0001888)2.61767586
35Facial diplegia (HP:0001349)2.61446385
36Abnormality of the columella (HP:0009929)2.61382878
37IgM deficiency (HP:0002850)2.49042689
38Eczematoid dermatitis (HP:0000976)2.48912335
39Recurrent bronchitis (HP:0002837)2.47462594
40Abnormality of DNA repair (HP:0003254)2.46511238
41Keratoconjunctivitis sicca (HP:0001097)2.45329181
42Congenital sensorineural hearing impairment (HP:0008527)2.41063485
43Neurodegeneration (HP:0002180)2.39388869
44Granulocytopenia (HP:0001913)2.38981043
45Submucous cleft hard palate (HP:0000176)2.38138507
46Increased cerebral lipofuscin (HP:0011813)2.36118381
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.35493517
48IgA deficiency (HP:0002720)2.32485029
49Neonatal respiratory distress (HP:0002643)2.31397444
50B lymphocytopenia (HP:0010976)2.30700477
51Thick nail (HP:0001805)2.30657200
52Prominent nose (HP:0000448)2.27599474
53Mesangial abnormality (HP:0001966)2.27449792
54Keratoconjunctivitis (HP:0001096)2.26633195
55Basal ganglia calcification (HP:0002135)2.24030240
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21461878
57Pulmonary infiltrates (HP:0002113)2.20053913
58Vasculitis (HP:0002633)2.16357189
59Recurrent cutaneous fungal infections (HP:0011370)2.15763825
60Chronic mucocutaneous candidiasis (HP:0002728)2.15763825
61Mediastinal lymphadenopathy (HP:0100721)2.15679318
62Cone-rod dystrophy (HP:0000548)2.15059091
63Periodontitis (HP:0000704)2.14225310
64Vacuolated lymphocytes (HP:0001922)2.13682489
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.09249658
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.09162583
67Reduced antithrombin III activity (HP:0001976)2.07242165
68Abnormality of polysaccharide metabolism (HP:0011012)2.05737415
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05737415
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05737415
71Disinhibition (HP:0000734)2.05240192
72Hypoplasia of the thymus (HP:0000778)2.04264433
73Encephalitis (HP:0002383)2.03630270
74Bilateral sensorineural hearing impairment (HP:0008619)2.00786916
75Keratitis (HP:0000491)1.98809677
76Anorexia (HP:0002039)1.97225900
77Hemoptysis (HP:0002105)1.96695786
78Arterial thrombosis (HP:0004420)1.95784794
79Loss of speech (HP:0002371)1.91238993
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86550037
81Abnormality of the basal ganglia (HP:0002134)1.83929424
82Gingival bleeding (HP:0000225)1.82015383
83Tubular atrophy (HP:0000092)1.81878154
84Abnormality of the prostate (HP:0008775)1.81020597
85Papilledema (HP:0001085)1.80854746
86Urinary glycosaminoglycan excretion (HP:0003541)1.80001039
87Mucopolysacchariduria (HP:0008155)1.80001039
88Albinism (HP:0001022)1.79747255
89Gingivitis (HP:0000230)1.79161891
90Urticaria (HP:0001025)1.78856916
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76804671
92Global brain atrophy (HP:0002283)1.75008988
93Chronic diarrhea (HP:0002028)1.74009393
94Abnormality of the pleura (HP:0002103)1.73018694
95Cellular immunodeficiency (HP:0005374)1.72467598
96Vertigo (HP:0002321)1.70958721
97Decreased central vision (HP:0007663)1.69227421
98Hypoalbuminemia (HP:0003073)1.68331762
99Abnormal albumin level (HP:0012116)1.68331762
100Lymphoma (HP:0002665)1.68324899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68116311
2MAP4K14.57245919
3MARK32.87408051
4TNIK2.64883868
5BLK2.42674401
6AKT32.38399445
7TXK2.29913856
8PIM22.29265479
9IKBKE2.22168903
10WNK32.15306128
11PAK32.15038021
12EIF2AK32.11481075
13PIK3CA2.02457977
14RIPK11.93715821
15IKBKB1.84471482
16CSK1.72198532
17MAP3K141.71171619
18SIK21.67821608
19ZAP701.60903438
20GRK71.60039049
21IRAK41.58924106
22TAF11.54670005
23NLK1.53218912
24PDK21.51822235
25MAPKAPK31.50516172
26ADRBK21.45176226
27STK101.39929311
28TAOK11.39777914
29FER1.36387973
30SYK1.31189964
31BMPR1B1.23970165
32CAMK1D1.20480407
33PBK1.17005804
34PLK21.16876349
35TLK11.15534654
36BTK1.14682612
37TYK21.14463575
38NUAK11.11110836
39KDR1.07907547
40IRAK31.07196215
41PRKCQ1.01130775
42NEK21.00610931
43TGFBR20.99815837
44FGR0.99553055
45KIT0.98783046
46EPHB10.95878033
47JAK10.95755549
48JAK30.91444366
49ERBB40.89547279
50PRKCI0.87595674
51CHUK0.85902919
52TBK10.85844264
53MST1R0.85559366
54HCK0.85134341
55CAMKK20.84224349
56ZAK0.83026496
57PIM10.82777161
58LCK0.82508098
59MAPK110.82353293
60ACVR1B0.81300067
61SGK20.80525518
62IRAK10.80458598
63CSF1R0.76910777
64PTK2B0.76783053
65STK40.75906010
66ITK0.74281499
67MAP3K30.73200549
68MATK0.70951843
69LYN0.65248905
70JAK20.59906430
71MAP2K30.59846727
72PAK10.59583649
73TNK20.59577108
74ABL10.56640980
75TEC0.56457330
76CAMK1G0.50901379
77OXSR10.50813294
78MAPKAPK50.49256352
79FES0.48894126
80INSRR0.48583953
81CDC42BPA0.47222922
82IGF1R0.47066679
83MAP3K50.45129484
84MELK0.42569192
85STK390.42201722
86PDGFRB0.41703167
87EGFR0.41085789
88RPS6KA50.40127090
89CSNK1A1L0.37730251
90IRAK20.35802319
91INSR0.35505497
92TRPM70.35409476
93PRKD10.35033186
94MKNK10.33658334
95CSNK1D0.32643060
96FLT30.32218933
97NEK60.31564430
98PDK10.31257841
99SGK30.30991979
100SGK2230.30798257

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.51850225
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.95035253
3Graft-versus-host disease_Homo sapiens_hsa053322.87087863
4Malaria_Homo sapiens_hsa051442.42567327
5Hematopoietic cell lineage_Homo sapiens_hsa046402.41853125
6Antigen processing and presentation_Homo sapiens_hsa046122.36513779
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33135812
8Allograft rejection_Homo sapiens_hsa053302.32570179
9T cell receptor signaling pathway_Homo sapiens_hsa046602.29177919
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28148647
11Legionellosis_Homo sapiens_hsa051342.19157111
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.14815242
13Osteoclast differentiation_Homo sapiens_hsa043802.14541657
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09915704
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.03233843
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02837418
17Autoimmune thyroid disease_Homo sapiens_hsa053201.94082473
18Measles_Homo sapiens_hsa051621.90070985
19Staphylococcus aureus infection_Homo sapiens_hsa051501.88420565
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82907814
21Pertussis_Homo sapiens_hsa051331.72205932
22Leishmaniasis_Homo sapiens_hsa051401.70259543
23TNF signaling pathway_Homo sapiens_hsa046681.58065661
24Rheumatoid arthritis_Homo sapiens_hsa053231.57410165
25Salmonella infection_Homo sapiens_hsa051321.53849415
26Tuberculosis_Homo sapiens_hsa051521.50741905
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47329336
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44860665
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41951459
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.41338812
31Shigellosis_Homo sapiens_hsa051311.38993666
32ABC transporters_Homo sapiens_hsa020101.37542400
33Type I diabetes mellitus_Homo sapiens_hsa049401.37523327
34Asthma_Homo sapiens_hsa053101.35336282
35Proteasome_Homo sapiens_hsa030501.33675937
36Lysosome_Homo sapiens_hsa041421.32980197
37Influenza A_Homo sapiens_hsa051641.31555166
38B cell receptor signaling pathway_Homo sapiens_hsa046621.26589826
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23211285
40Herpes simplex infection_Homo sapiens_hsa051681.17601205
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15675334
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13106620
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10842385
44Hepatitis C_Homo sapiens_hsa051601.09436046
45African trypanosomiasis_Homo sapiens_hsa051431.07629798
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.03113286
47Collecting duct acid secretion_Homo sapiens_hsa049661.00556634
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.99037742
49Toxoplasmosis_Homo sapiens_hsa051450.96620727
50Selenocompound metabolism_Homo sapiens_hsa004500.96213075
51Apoptosis_Homo sapiens_hsa042100.90144797
52Chemokine signaling pathway_Homo sapiens_hsa040620.89904707
53Systemic lupus erythematosus_Homo sapiens_hsa053220.85971137
54Other glycan degradation_Homo sapiens_hsa005110.84214840
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83114798
56Dorso-ventral axis formation_Homo sapiens_hsa043200.81447374
57Nitrogen metabolism_Homo sapiens_hsa009100.81222996
58Phagosome_Homo sapiens_hsa041450.77019783
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76625588
60Hepatitis B_Homo sapiens_hsa051610.75831114
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75611991
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70125039
63Epstein-Barr virus infection_Homo sapiens_hsa051690.68235212
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66305491
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61994689
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.59814329
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59370856
68Viral myocarditis_Homo sapiens_hsa054160.58593493
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53114248
70Platelet activation_Homo sapiens_hsa046110.51021073
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49492140
72FoxO signaling pathway_Homo sapiens_hsa040680.48696496
73Acute myeloid leukemia_Homo sapiens_hsa052210.47476746
74RNA polymerase_Homo sapiens_hsa030200.46428767
75Peroxisome_Homo sapiens_hsa041460.44880653
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41897368
77Fatty acid biosynthesis_Homo sapiens_hsa000610.39270144
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34797817
79Steroid biosynthesis_Homo sapiens_hsa001000.34655683
80Viral carcinogenesis_Homo sapiens_hsa052030.34325732
81HTLV-I infection_Homo sapiens_hsa051660.32636323
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32074124
83Olfactory transduction_Homo sapiens_hsa047400.30211423
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29155762
85Butanoate metabolism_Homo sapiens_hsa006500.27900957
86Lysine degradation_Homo sapiens_hsa003100.26139146
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.25870558
88Tryptophan metabolism_Homo sapiens_hsa003800.22977796
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22479589
90Prostate cancer_Homo sapiens_hsa052150.22130738
91RNA degradation_Homo sapiens_hsa030180.21655632
92Pancreatic cancer_Homo sapiens_hsa052120.21191544
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.20635666
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19633475
95Ether lipid metabolism_Homo sapiens_hsa005650.18965014
96Complement and coagulation cascades_Homo sapiens_hsa046100.18040152
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17632162
98Non-small cell lung cancer_Homo sapiens_hsa052230.16456496
99Mineral absorption_Homo sapiens_hsa049780.16045246
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.15293282

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