FDX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to follicle-stimulating hormone (GO:0032354)9.70033717
2cellular response to antibiotic (GO:0071236)8.65581492
3cellular response to gonadotropin stimulus (GO:0071371)7.93614180
4response to insecticide (GO:0017085)6.65515684
5cellular response to toxic substance (GO:0097237)6.33978609
6estrogen biosynthetic process (GO:0006703)6.26889236
7L-phenylalanine metabolic process (GO:0006558)6.25321146
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.25321146
9L-phenylalanine catabolic process (GO:0006559)6.24713929
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.24713929
11low-density lipoprotein particle clearance (GO:0034383)6.12933964
12glyoxylate metabolic process (GO:0046487)5.91592762
13response to gonadotropin (GO:0034698)5.74927495
14* hormone biosynthetic process (GO:0042446)5.74301735
15Leydig cell differentiation (GO:0033327)5.67808441
16aromatic amino acid family catabolic process (GO:0009074)5.57840098
17bile acid biosynthetic process (GO:0006699)5.41240284
18androgen biosynthetic process (GO:0006702)5.26261690
19vitamin D metabolic process (GO:0042359)5.22182859
20C21-steroid hormone biosynthetic process (GO:0006700)5.21005002
21sulfur amino acid catabolic process (GO:0000098)5.14368919
22ketone biosynthetic process (GO:0042181)5.12169079
23indole-containing compound catabolic process (GO:0042436)5.02796778
24indolalkylamine catabolic process (GO:0046218)5.02796778
25tryptophan catabolic process (GO:0006569)5.02796778
26glucocorticoid biosynthetic process (GO:0006704)4.96086847
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.93931993
28kynurenine metabolic process (GO:0070189)4.92572511
29alpha-linolenic acid metabolic process (GO:0036109)4.90702002
30cellular response to interferon-alpha (GO:0035457)4.88656186
31high-density lipoprotein particle remodeling (GO:0034375)4.85456226
32cysteine metabolic process (GO:0006534)4.82265684
33positive regulation of hormone biosynthetic process (GO:0046886)4.76624864
34tryptophan metabolic process (GO:0006568)4.76593746
35benzene-containing compound metabolic process (GO:0042537)4.72684873
36response to phenylpropanoid (GO:0080184)4.62570995
37lysine catabolic process (GO:0006554)4.58635707
38lysine metabolic process (GO:0006553)4.58635707
39regulation of cholesterol storage (GO:0010885)4.57624817
40serine family amino acid catabolic process (GO:0009071)4.55894669
41bile acid metabolic process (GO:0008206)4.49156544
42urea metabolic process (GO:0019627)4.47053321
43urea cycle (GO:0000050)4.47053321
44regulation of protein activation cascade (GO:2000257)4.39384918
45cellular response to epinephrine stimulus (GO:0071872)4.37161843
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32848711
47amino-acid betaine metabolic process (GO:0006577)4.32809585
48negative regulation of fibrinolysis (GO:0051918)4.31977888
49protein carboxylation (GO:0018214)4.28882928
50peptidyl-glutamic acid carboxylation (GO:0017187)4.28882928
51complement activation, alternative pathway (GO:0006957)4.28787241
52adhesion of symbiont to host (GO:0044406)4.25370080
53nitrogen cycle metabolic process (GO:0071941)4.24428522
54aromatic amino acid family metabolic process (GO:0009072)4.24151083
55positive regulation of triglyceride biosynthetic process (GO:0010867)4.23940818
56reverse cholesterol transport (GO:0043691)4.21836400
57homocysteine metabolic process (GO:0050667)4.20987713
58ethanol oxidation (GO:0006069)4.20797307
59regulation of triglyceride catabolic process (GO:0010896)4.20582532
60cellular response to growth hormone stimulus (GO:0071378)4.19930181
61regulation of complement activation (GO:0030449)4.16522005
62toxin metabolic process (GO:0009404)4.15103714
63cytokine metabolic process (GO:0042107)4.14057970
64glycine metabolic process (GO:0006544)4.12465200
65regulation of fibrinolysis (GO:0051917)4.10522631
66acylglycerol homeostasis (GO:0055090)4.08204766
67triglyceride homeostasis (GO:0070328)4.08204766
68response to vitamin E (GO:0033197)4.07907142
69plasma lipoprotein particle remodeling (GO:0034369)4.06740865
70protein-lipid complex remodeling (GO:0034368)4.06740865
71macromolecular complex remodeling (GO:0034367)4.06740865
72cellular ketone body metabolic process (GO:0046950)4.04526979
73glucocorticoid metabolic process (GO:0008211)4.02469769
74oligosaccharide catabolic process (GO:0009313)3.99695898
75alpha-amino acid catabolic process (GO:1901606)3.97222166
76C21-steroid hormone metabolic process (GO:0008207)3.96643773
77aldehyde catabolic process (GO:0046185)3.88513310
78cellular response to cadmium ion (GO:0071276)3.87155680
79response to methylmercury (GO:0051597)3.87045950
80serine family amino acid metabolic process (GO:0009069)3.86575801
81glycosphingolipid catabolic process (GO:0046479)3.85100733
82* steroid biosynthetic process (GO:0006694)3.84872471
83regulation of cholesterol esterification (GO:0010872)3.82771229
84response to corticosterone (GO:0051412)3.81601154
85response to epinephrine (GO:0071871)3.79947616
86cellular amino acid catabolic process (GO:0009063)3.77025868
87amyloid precursor protein catabolic process (GO:0042987)3.76351969
88tyrosine metabolic process (GO:0006570)3.76242194
89detection of molecule of bacterial origin (GO:0032490)3.76145161
90plasma lipoprotein particle clearance (GO:0034381)3.72646415
91cellular glucuronidation (GO:0052695)3.71735521
92estrogen metabolic process (GO:0008210)3.68810996
932-oxoglutarate metabolic process (GO:0006103)3.67543826
94progesterone metabolic process (GO:0042448)3.66284234
95intracellular lipid transport (GO:0032365)3.65291454
96epoxygenase P450 pathway (GO:0019373)3.64497788
97fatty acid beta-oxidation (GO:0006635)3.63134342
98serine family amino acid biosynthetic process (GO:0009070)3.62618343
99sterol catabolic process (GO:0016127)3.62600257
100cholesterol catabolic process (GO:0006707)3.62600257
101steroid catabolic process (GO:0006706)3.62316931
102short-chain fatty acid metabolic process (GO:0046459)3.62131509
103positive regulation of male gonad development (GO:2000020)3.62045879
104negative regulation of cholesterol transport (GO:0032375)3.59190264
105negative regulation of sterol transport (GO:0032372)3.59190264
106sterol transport (GO:0015918)3.56440477
107cholesterol transport (GO:0030301)3.56440477
108bile acid and bile salt transport (GO:0015721)3.56177790
109fatty acid oxidation (GO:0019395)3.54625461
110indolalkylamine metabolic process (GO:0006586)3.53657061
111glycolipid catabolic process (GO:0019377)3.53228138
112mating behavior (GO:0007617)3.51646726
113cholesterol efflux (GO:0033344)3.51582651
114very-low-density lipoprotein particle assembly (GO:0034379)3.48110930
115organic acid catabolic process (GO:0016054)3.48047569
116carboxylic acid catabolic process (GO:0046395)3.48047569
117ketone body metabolic process (GO:1902224)3.47699859
118coenzyme catabolic process (GO:0009109)3.47660370
119positive regulation of hormone metabolic process (GO:0032352)3.47241579
120cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.46566842
121lipid oxidation (GO:0034440)3.46482447
122fatty acid catabolic process (GO:0009062)3.45455130
123positive regulation of nitric-oxide synthase activity (GO:0051000)3.45026140
124cellular ketone metabolic process (GO:0042180)3.44959618
125cellular biogenic amine catabolic process (GO:0042402)3.42659470
126amine catabolic process (GO:0009310)3.42659470
127response to leptin (GO:0044321)3.42453336
128ovulation (GO:0030728)3.42157590
129phospholipid efflux (GO:0033700)3.41607667
130response to nitrosative stress (GO:0051409)3.41482625
131valine metabolic process (GO:0006573)3.41217885
132monocarboxylic acid catabolic process (GO:0072329)3.40630153
133* sterol metabolic process (GO:0016125)3.39425963
134uronic acid metabolic process (GO:0006063)3.38693668
135glucuronate metabolic process (GO:0019585)3.38693668
136carnitine metabolic process (GO:0009437)3.38661993
137cellular modified amino acid catabolic process (GO:0042219)3.38027568
138phagocytosis, recognition (GO:0006910)3.37463079
139regulation of cholesterol metabolic process (GO:0090181)3.36943696
140cholesterol homeostasis (GO:0042632)3.36640132
141androgen metabolic process (GO:0008209)3.34866508
142imidazole-containing compound metabolic process (GO:0052803)3.33808558
143aspartate family amino acid catabolic process (GO:0009068)3.33454392
144plasma lipoprotein particle assembly (GO:0034377)3.32422894
145sterol homeostasis (GO:0055092)3.32085567
146positive regulation of triglyceride metabolic process (GO:0090208)3.31971271
147response to lead ion (GO:0010288)3.28964519
148positive regulation of steroid biosynthetic process (GO:0010893)3.24362723
149ceramide catabolic process (GO:0046514)3.24263733
150parturition (GO:0007567)3.22344835
151response to cadmium ion (GO:0046686)3.16336717
152cellular response to dexamethasone stimulus (GO:0071549)3.13557991
153regulation of male gonad development (GO:2000018)3.05880114
154cellular hormone metabolic process (GO:0034754)3.01631979
155regulation of triglyceride biosynthetic process (GO:0010866)2.97180466
156response to antibiotic (GO:0046677)2.97000430
157positive regulation of monooxygenase activity (GO:0032770)2.96298226
158response to lipoprotein particle (GO:0055094)2.94111956
159response to dexamethasone (GO:0071548)2.90539164
160regulation of steroid biosynthetic process (GO:0050810)2.90250433
161regulation of steroid hormone biosynthetic process (GO:0090030)2.87042691
162response to mineralocorticoid (GO:0051385)2.85358114
163* cholesterol metabolic process (GO:0008203)2.79685360
164positive regulation of steroid metabolic process (GO:0045940)2.77431810
165L-ascorbic acid metabolic process (GO:0019852)2.71875265
166regulation of gonadotropin secretion (GO:0032276)2.68454970
1673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67709793
168purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67709793
169positive regulation of lipid storage (GO:0010884)2.64256840
170regulation of cholesterol biosynthetic process (GO:0045540)2.59685195
171cholesterol biosynthetic process (GO:0006695)2.55475229
172regulation of female gonad development (GO:2000194)2.54988587
173plasma lipoprotein particle organization (GO:0071827)2.54979893
174protein-lipid complex subunit organization (GO:0071825)2.51099381
175sulfation (GO:0051923)2.48351919
176fat-soluble vitamin metabolic process (GO:0006775)2.47799208
177negative regulation of macrophage differentiation (GO:0045650)2.45988718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.93474020
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.11702005
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00730623
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.60313540
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.29852434
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.16572174
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.78154129
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52209103
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15183372
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52999159
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.19862145
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.02355270
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78753683
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.73046851
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.46518014
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.36368101
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05916568
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0493917
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96249753
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95438137
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93600094
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91004962
23CLOCK_20551151_ChIP-Seq_293T_Human1.84692834
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70111170
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66319379
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61368727
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57079876
28VDR_24787735_ChIP-Seq_THP-1_Human1.53066115
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49604822
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46107121
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45969732
32ZNF263_19887448_ChIP-Seq_K562_Human1.45956238
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43702364
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43422250
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43220447
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42102670
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40224972
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40224972
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39587956
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36632043
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34066197
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32965477
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.32684335
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29730894
45TFEB_21752829_ChIP-Seq_HELA_Human1.29355921
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29284814
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25220659
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24846852
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.23987815
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22728171
51ELK1_19687146_ChIP-ChIP_HELA_Human1.20994936
52GATA3_26560356_Chip-Seq_TH2_Human1.19990832
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19518858
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18509039
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17218081
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.15388928
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15045636
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.13401418
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.12999815
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.12764345
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10752558
62VDR_23849224_ChIP-Seq_CD4+_Human1.10743826
63HTT_18923047_ChIP-ChIP_STHdh_Human1.09038457
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.08694826
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06217106
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05635423
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04648216
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04116340
69GATA4_25053715_ChIP-Seq_YYC3_Human1.03301734
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03240861
71SOX2_20726797_ChIP-Seq_SW620_Human1.02989164
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02235702
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.02199095
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01548336
75SPI1_23547873_ChIP-Seq_NB4_Human1.00731236
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99545683
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97855799
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97381935
79SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96607011
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95115145
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94809805
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94748051
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92581277
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92362873
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.91212351
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90732713
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90656083
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89712955
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.89548593
90GATA1_22025678_ChIP-Seq_K562_Human0.87584866
91RARA_24833708_ChIP-Seq_LIVER_Mouse0.87570913
92PU_27001747_Chip-Seq_BMDM_Mouse0.87091242
93FOXA2_19822575_ChIP-Seq_HepG2_Human0.86782341
94AR_21909140_ChIP-Seq_LNCAP_Human0.86434084
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85952409
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85733767
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85279371
98CBP_21632823_ChIP-Seq_H3396_Human0.85243377
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.84658794
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84130726
101DCP1A_22483619_ChIP-Seq_HELA_Human0.83641141
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.83393801
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83263572
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83240342
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82968839
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.82835280
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82786825
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82660375
109OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82603053
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.81811780
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81278483
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80471221
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80469820
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79587412
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78881877
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78508387
117IGF1R_20145208_ChIP-Seq_DFB_Human0.78407146
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78385783
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77898147
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.77452708
121RARB_24833708_ChIP-Seq_LIVER_Mouse0.77401867
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76452150
123GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76131962
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76113781
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71345173
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69331693
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68915380
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68858584
129MYC_19030024_ChIP-ChIP_MESCs_Mouse0.67433419
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66968767
131GABP_19822575_ChIP-Seq_HepG2_Human0.66602170
132ATF3_27146783_Chip-Seq_COLON_Human0.65523517
133* GATA6_25053715_ChIP-Seq_YYC3_Human0.65171534
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65049534
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.64640588
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64604915
137NELFA_20434984_ChIP-Seq_ESCs_Mouse0.64248731
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.64086710
139NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.63491390
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.63410164
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.63407305
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.61146050
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61020983
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.61019142
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60699925
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.60478413
147CEBPB_22108803_ChIP-Seq_LS180_Human0.60450459
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60243279
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.59673645
150AR_20517297_ChIP-Seq_VCAP_Human0.59613717
151LXR_22292898_ChIP-Seq_THP-1_Human0.59437748
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57528863
153ESR1_21235772_ChIP-Seq_MCF-7_Human0.56868357
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.56392908
155XRN2_22483619_ChIP-Seq_HELA_Human0.55345546
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.54131361
157BCOR_27268052_Chip-Seq_Bcells_Human0.54021583
158IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53579789
159* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53560183
160RACK7_27058665_Chip-Seq_MCF-7_Human0.53157693
161SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.53076792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.25667756
2MP0005360_urolithiasis6.68328318
3MP0005085_abnormal_gallbladder_physiolo5.67760351
4MP0005365_abnormal_bile_salt5.54642484
5MP0008875_abnormal_xenobiotic_pharmacok4.83414503
6MP0003806_abnormal_nucleotide_metabolis4.05893862
7MP0010329_abnormal_lipoprotein_level3.31755966
8MP0003252_abnormal_bile_duct3.23695895
9MP0003195_calcinosis3.14383839
10MP0009840_abnormal_foam_cell3.09219481
11MP0005332_abnormal_amino_acid2.81681657
12MP0008004_abnormal_stomach_pH2.74333580
13MP0008995_early_reproductive_senescence2.71223511
14MP0005083_abnormal_biliary_tract2.58384669
15MP0001666_abnormal_nutrient_absorption2.42878491
16MP0003191_abnormal_cellular_cholesterol2.33139194
17MP0004019_abnormal_vitamin_homeostasis2.29823876
18MP0006082_CNS_inflammation2.19224480
19MP0005319_abnormal_enzyme/_coenzyme2.12123107
20MP0003186_abnormal_redox_activity2.05869923
21MP0000609_abnormal_liver_physiology2.05435712
22MP0002118_abnormal_lipid_homeostasis1.99681996
23MP0000647_abnormal_sebaceous_gland1.96810925
24MP0003300_gastrointestinal_ulcer1.88549767
25MP0003941_abnormal_skin_development1.87922673
26MP0002138_abnormal_hepatobiliary_system1.77620269
27MP0005379_endocrine/exocrine_gland_phen1.74140298
28MP0002148_abnormal_hypersensitivity_rea1.72187453
29MP0000639_abnormal_adrenal_gland1.67200303
30MP0009643_abnormal_urine_homeostasis1.66566798
31MP0005584_abnormal_enzyme/coenzyme_acti1.66181007
32MP0003303_peritoneal_inflammation1.61690587
33MP0005647_abnormal_sex_gland1.60639435
34MP0001764_abnormal_homeostasis1.57042606
35MP0005636_abnormal_mineral_homeostasis1.56177329
36MP0003329_amyloid_beta_deposits1.55609484
37MP0006036_abnormal_mitochondrial_physio1.54021792
38MP0009697_abnormal_copulation1.53834767
39MP0000343_altered_response_to1.52968803
40MP0003950_abnormal_plasma_membrane1.50349118
41MP0003868_abnormal_feces_composition1.46247782
42MP0003315_abnormal_perineum_morphology1.43976110
43MP0003011_delayed_dark_adaptation1.39398063
44MP0009785_altered_susceptibility_to1.38046434
45MP0002090_abnormal_vision1.30853175
46MP0002909_abnormal_adrenal_gland1.30109609
47MP0009379_abnormal_foot_pigmentation1.29536265
48MP0005451_abnormal_body_composition1.29478933
49MP0006035_abnormal_mitochondrial_morpho1.28207703
50MP0001661_extended_life_span1.26515085
51MP0005167_abnormal_blood-brain_barrier1.26057914
52MP0003786_premature_aging1.25905488
53MP0002419_abnormal_innate_immunity1.24383230
54MP0000598_abnormal_liver_morphology1.21309992
55MP0010368_abnormal_lymphatic_system1.17209266
56MP0002877_abnormal_melanocyte_morpholog1.16879090
57MP0010234_abnormal_vibrissa_follicle1.14828428
58MP0003656_abnormal_erythrocyte_physiolo1.13059803
59MP0003690_abnormal_glial_cell1.12724177
60MP0002332_abnormal_exercise_endurance1.06540773
61MP0006054_spinal_hemorrhage1.05750039
62MP0001835_abnormal_antigen_presentation1.05228371
63MP0002998_abnormal_bone_remodeling1.04836403
64MP0008469_abnormal_protein_level0.99020909
65MP0005220_abnormal_exocrine_pancreas0.98418448
66MP0009642_abnormal_blood_homeostasis0.95931942
67MP0001756_abnormal_urination0.94963142
68MP0001790_abnormal_immune_system0.93287180
69MP0005387_immune_system_phenotype0.93287180
70MP0003122_maternal_imprinting0.93079139
71MP0002452_abnormal_antigen_presenting0.92600525
72MP0005084_abnormal_gallbladder_morpholo0.91434544
73MP0003705_abnormal_hypodermis_morpholog0.90502216
74MP0009333_abnormal_splenocyte_physiolog0.90034597
75MP0000465_gastrointestinal_hemorrhage0.89955938
76MP0005000_abnormal_immune_tolerance0.89628721
77MP0003172_abnormal_lysosome_physiology0.89417515
78MP0003075_altered_response_to0.89250520
79MP0004130_abnormal_muscle_cell0.89080902
80MP0005670_abnormal_white_adipose0.88669608
81MP0009763_increased_sensitivity_to0.88152277
82MP0001765_abnormal_ion_homeostasis0.85551223
83MP0005376_homeostasis/metabolism_phenot0.84805277
84MP0003718_maternal_effect0.81823190
85MP0000230_abnormal_systemic_arterial0.81001440
86MP0004510_myositis0.80978835
87MP0009384_cardiac_valve_regurgitation0.80518751
88MP0009764_decreased_sensitivity_to0.80497566
89MP0002078_abnormal_glucose_homeostasis0.80004877
90MP0005310_abnormal_salivary_gland0.79885966
91MP0005671_abnormal_response_to0.79877651
92MP0005266_abnormal_metabolism0.79065324
93MP0005164_abnormal_response_to0.78056133
94MP0005408_hypopigmentation0.77709388
95MP0001879_abnormal_lymphatic_vessel0.77528435
96MP0005025_abnormal_response_to0.77525154
97MP0002971_abnormal_brown_adipose0.76797714
98MP0002723_abnormal_immune_serum0.76271319
99MP0000013_abnormal_adipose_tissue0.73003230
100MP0005334_abnormal_fat_pad0.71370488
101MP0004947_skin_inflammation0.71205385
102MP0004043_abnormal_pH_regulation0.69690620
103MP0003959_abnormal_lean_body0.67738672
104MP0003953_abnormal_hormone_level0.67083983
105MP0005166_decreased_susceptibility_to0.66971705
106MP0009053_abnormal_anal_canal0.66582571
107MP0002160_abnormal_reproductive_system0.65633469
108MP0004782_abnormal_surfactant_physiolog0.65282811
109MP0010678_abnormal_skin_adnexa0.65008582
110MP0005253_abnormal_eye_physiology0.64767805
111MP0002136_abnormal_kidney_physiology0.63929067
112MP0002938_white_spotting0.62886346
113MP0005666_abnormal_adipose_tissue0.60978884
114MP0005535_abnormal_body_temperature0.57516798
115MP0002876_abnormal_thyroid_physiology0.57396251
116MP0002837_dystrophic_cardiac_calcinosis0.57255252
117MP0005395_other_phenotype0.56875491
118MP0001881_abnormal_mammary_gland0.56873902
119MP0003646_muscle_fatigue0.56375225
120MP0003638_abnormal_response/metabolism_0.56262002
121MP0009765_abnormal_xenobiotic_induced0.55870097
122MP0002269_muscular_atrophy0.54435033
123MP0000604_amyloidosis0.52917181
124MP0005330_cardiomyopathy0.52052876
125MP0003724_increased_susceptibility_to0.48632773
126MP0001919_abnormal_reproductive_system0.47350117
127MP0002796_impaired_skin_barrier0.46251313
128MP0002254_reproductive_system_inflammat0.45529520
129MP0001853_heart_inflammation0.44701837
130MP0003699_abnormal_female_reproductive0.43991789
131MP0005389_reproductive_system_phenotype0.43760668
132MP0001119_abnormal_female_reproductive0.43752099
133MP0003221_abnormal_cardiomyocyte_apopto0.41674234
134MP0004147_increased_porphyrin_level0.41511084
135MP0000358_abnormal_cell_content/0.41050460
136MP0004883_abnormal_blood_vessel0.41005359
137MP0005187_abnormal_penis_morphology0.40671810
138MP0005448_abnormal_energy_balance0.40553785
139MP0002970_abnormal_white_adipose0.39475243
140MP0004264_abnormal_extraembryonic_tissu0.39039038
141MP0008873_increased_physiological_sensi0.38242905
142MP0005058_abnormal_lysosome_morphology0.37549853
143MP0009115_abnormal_fat_cell0.36659685
144MP0001845_abnormal_inflammatory_respons0.36569006
145MP0000249_abnormal_blood_vessel0.35887956
146MP0000538_abnormal_urinary_bladder0.35090706
147MP0002135_abnormal_kidney_morphology0.34105772
148MP0005464_abnormal_platelet_physiology0.33114048
149MP0001944_abnormal_pancreas_morphology0.32958882

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.63267394
2Abnormality of glycolipid metabolism (HP:0010969)6.19498081
3Abnormality of liposaccharide metabolism (HP:0010968)6.19498081
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.19498081
5Intrahepatic cholestasis (HP:0001406)5.95055733
6Deep venous thrombosis (HP:0002625)5.68148587
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.43798683
8Xanthomatosis (HP:0000991)5.31280170
9Hypobetalipoproteinemia (HP:0003563)5.31254110
10Prolonged partial thromboplastin time (HP:0003645)5.08315669
11Hyperammonemia (HP:0001987)4.60052473
12Hyperglycinemia (HP:0002154)4.55360969
13Hyperglycinuria (HP:0003108)4.40178199
14Hypoglycemic coma (HP:0001325)4.34795400
15Hyperlipoproteinemia (HP:0010980)4.28964382
16Complement deficiency (HP:0004431)4.22457450
17Ketosis (HP:0001946)4.17070975
18Abnormality of serine family amino acid metabolism (HP:0010894)4.15703270
19Abnormality of glycine metabolism (HP:0010895)4.15703270
20Hypolipoproteinemia (HP:0010981)4.07566001
21Decreased circulating renin level (HP:0003351)4.05886290
22Abnormality of fatty-acid metabolism (HP:0004359)4.03755147
23Vacuolated lymphocytes (HP:0001922)3.93126342
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85558185
25Epidermoid cyst (HP:0200040)3.75148668
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.71651590
27Eczematoid dermatitis (HP:0000976)3.65909162
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64083681
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.59673823
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.59022558
31Dicarboxylic aciduria (HP:0003215)3.59022558
32Hypoalphalipoproteinemia (HP:0003233)3.57828438
33Fat malabsorption (HP:0002630)3.53245387
34Abnormality of methionine metabolism (HP:0010901)3.51367612
35Abnormality of the common coagulation pathway (HP:0010990)3.49274510
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.43337652
37Joint hemorrhage (HP:0005261)3.40464671
38Abnormality of the intrinsic pathway (HP:0010989)3.30328849
39Increased cerebral lipofuscin (HP:0011813)3.29058779
40Gonadal dysgenesis (HP:0000133)3.28957961
41Hypokalemic alkalosis (HP:0001949)3.28416915
42Ketoacidosis (HP:0001993)3.28360503
43Abnormality of serum amino acid levels (HP:0003112)3.27037300
44Recurrent gram-negative bacterial infections (HP:0005420)3.20686825
45Abnormality of mucopolysaccharide metabolism (HP:0011020)3.19546672
46Abnormality of polysaccharide metabolism (HP:0011012)3.19546672
47Abnormality of glycosaminoglycan metabolism (HP:0004371)3.19546672
48Lethargy (HP:0001254)3.18629253
49Gonadotropin excess (HP:0000837)3.16438190
50Mucopolysacchariduria (HP:0008155)3.15413602
51Urinary glycosaminoglycan excretion (HP:0003541)3.15413602
52Abnormality of complement system (HP:0005339)3.08640465
53Cerebral edema (HP:0002181)3.08015073
54Delayed CNS myelination (HP:0002188)3.04752730
55Abnormality of pyrimidine metabolism (HP:0004353)3.01625082
56Loss of speech (HP:0002371)3.01047805
57Cerebral palsy (HP:0100021)2.99094434
58Metabolic acidosis (HP:0001942)2.96921927
59Abnormality of macrophages (HP:0004311)2.96677291
60Generalized aminoaciduria (HP:0002909)2.96504295
61Neonatal onset (HP:0003623)2.90942190
62Testicular neoplasm (HP:0010788)2.89127856
63Dysostosis multiplex (HP:0000943)2.88347619
64Large earlobe (HP:0009748)2.87790950
65Gout (HP:0001997)2.86175748
66Male pseudohermaphroditism (HP:0000037)2.85231930
67Hyperbilirubinemia (HP:0002904)2.82819776
68Clitoromegaly (HP:0000057)2.82723058
69Hypercholesterolemia (HP:0003124)2.79087114
70Renal salt wasting (HP:0000127)2.78638620
71Abnormality of nucleobase metabolism (HP:0010932)2.77370348
72Autoimmune thrombocytopenia (HP:0001973)2.75605691
73Steatorrhea (HP:0002570)2.75435448
74Secondary amenorrhea (HP:0000869)2.72559501
75Conjugated hyperbilirubinemia (HP:0002908)2.70335424
76Adrenal overactivity (HP:0002717)2.66380682
77Nausea (HP:0002018)2.66363885
78Abnormality of purine metabolism (HP:0004352)2.65242980
79Sensorimotor neuropathy (HP:0007141)2.64730991
80Hepatic necrosis (HP:0002605)2.64098496
81Abnormal cartilage morphology (HP:0002763)2.61805798
82Aplasia/hypoplasia of the uterus (HP:0008684)2.60954696
83Hyperpituitarism (HP:0010514)2.60691057
84Neurofibrillary tangles (HP:0002185)2.52524215
85Abnormal spermatogenesis (HP:0008669)2.51095367
86Vomiting (HP:0002013)2.49706608
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.48811625
88Proximal tubulopathy (HP:0000114)2.45040691
89Accelerated skeletal maturation (HP:0005616)2.44110324
90Prolonged neonatal jaundice (HP:0006579)2.43204888
91Enlarged penis (HP:0000040)2.41028884
92Multiple enchondromatosis (HP:0005701)2.39766515
93Skin nodule (HP:0200036)2.38652365
94Spontaneous abortion (HP:0005268)2.37917938
95Hepatocellular carcinoma (HP:0001402)2.31864199
96Asymmetric septal hypertrophy (HP:0001670)2.31545685
97Abnormality of urine glucose concentration (HP:0011016)2.29888911
98Glycosuria (HP:0003076)2.29888911
99Brushfield spots (HP:0001088)2.29404340
100Premature ovarian failure (HP:0008209)2.25636842
101Hyperaldosteronism (HP:0000859)2.23465217
102Late onset (HP:0003584)2.23233687
103Increased CSF protein (HP:0002922)2.20401771
104Mediastinal lymphadenopathy (HP:0100721)2.20265821
105Acute encephalopathy (HP:0006846)2.19997916
106Increased muscle lipid content (HP:0009058)2.19144883
107Myocardial infarction (HP:0001658)2.18014452
108Hydroxyprolinuria (HP:0003080)2.16829483
109Abnormality of proline metabolism (HP:0010907)2.16829483
110Hypoglycemic seizures (HP:0002173)2.16723734
111Irritability (HP:0000737)2.15869300
112Vascular calcification (HP:0004934)2.15414502
113Female pseudohermaphroditism (HP:0010458)2.12997050
114Pancreatitis (HP:0001733)2.11795935
115Malnutrition (HP:0004395)2.10969276
116Rhabdomyolysis (HP:0003201)2.09464494
117Renal cortical cysts (HP:0000803)2.06714698
118Abnormal hemoglobin (HP:0011902)2.05705064
119Hyperuricemia (HP:0002149)2.02378337
120Increased purine levels (HP:0004368)2.02378337
121Spastic diplegia (HP:0001264)2.01281113
122Abnormal sex determination (HP:0012244)1.98300347
123Sex reversal (HP:0012245)1.98300347
124Alkalosis (HP:0001948)1.95699971
125Methylmalonic aciduria (HP:0012120)1.94976392
126Acanthocytosis (HP:0001927)1.94959305
127Joint swelling (HP:0001386)1.94652338
128Hepatosplenomegaly (HP:0001433)1.93649804
129Systemic lupus erythematosus (HP:0002725)1.92960780
130CNS demyelination (HP:0007305)1.92790273
131Azoospermia (HP:0000027)1.92367556
132Hypoplasia of the uterus (HP:0000013)1.91686947
133Gynecomastia (HP:0000771)1.90341140
134Anomalous pulmonary venous return (HP:0010772)1.90102390
135Hyperinsulinemic hypoglycemia (HP:0000825)1.89055806
136Lactic acidosis (HP:0003128)1.88953084
137Cardiovascular calcification (HP:0011915)1.87993665
138Esophageal varix (HP:0002040)1.87764831
139Disinhibition (HP:0000734)1.87595242
140Hepatocellular necrosis (HP:0001404)1.86834578
141Thrombophlebitis (HP:0004418)1.86779325
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86664069
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86664069
144Growth hormone excess (HP:0000845)1.86181096
145Abnormal gallbladder morphology (HP:0012437)1.85741476
146Myoglobinuria (HP:0002913)1.85622713
147Abnormality of the clitoris (HP:0000056)1.85469502
148Opisthotonus (HP:0002179)1.85312369
149Cholelithiasis (HP:0001081)1.83264166
150Abnormality of renin-angiotensin system (HP:0000847)1.78205000
1513-Methylglutaconic aciduria (HP:0003535)1.74329194
152Recurrent bacterial skin infections (HP:0005406)1.73083655
153Neoplasm of head and neck (HP:0012288)1.72354613
154Esophageal neoplasm (HP:0100751)1.72354613
155Progressive neurologic deterioration (HP:0002344)1.71661037
156Symptomatic seizures (HP:0011145)1.71151306
157Acute necrotizing encephalopathy (HP:0006965)1.70067842
158Pulmonary fibrosis (HP:0002206)1.69718806
159Abnormality of the pulmonary veins (HP:0011718)1.69532423
160Metaphyseal dysplasia (HP:0100255)1.68974848
161Mitochondrial inheritance (HP:0001427)1.67848073
162Partial agenesis of the corpus callosum (HP:0001338)1.66826147
163Increased serum pyruvate (HP:0003542)1.66550520
164Abnormality of alanine metabolism (HP:0010916)1.65329996
165Hyperalaninemia (HP:0003348)1.65329996
166Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65329996
167Tongue fasciculations (HP:0001308)1.65263220
168Abnormal mitochondria in muscle tissue (HP:0008316)1.65045097
169Increased intramyocellular lipid droplets (HP:0012240)1.64947825
170Respiratory failure (HP:0002878)1.64534210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.92837555
2ERN14.28137178
3FGFR42.81159496
4TRIB32.73197292
5NME22.63215539
6MST42.49219977
7PKN22.41460432
8TAOK32.38020615
9FLT32.30130206
10GRK72.28588155
11SIK12.27794533
12PIK3CG2.15751072
13MAP3K142.11736715
14KDR2.02303070
15NEK92.01416312
16MAP3K121.91024615
17PDK41.89428674
18PDK31.89428674
19BMPR21.85725120
20MST1R1.84164194
21TXK1.75237019
22PINK11.74701794
23TAOK21.71172700
24MAPK111.65078252
25ABL21.58412283
26STK101.55451159
27ERBB41.52591205
28STK161.49446344
29EIF2AK11.48821473
30MAP3K111.46078830
31BLK1.43715331
32MAP3K31.42713756
33INSRR1.42634681
34JAK11.39181846
35ADRBK21.38952187
36PBK1.38743565
37PDK21.37193064
38IKBKB1.37190400
39CAMKK21.32793101
40AKT31.28083270
41IRAK31.27240439
42STK38L1.25930235
43BMPR1B1.24966055
44TYK21.16638111
45TESK11.16112743
46TBK11.15348943
47MOS1.13931158
48AKT21.11714291
49PIM21.10659703
50PTK61.09794497
51MYLK1.09200761
52WEE11.09166664
53ERBB31.08573331
54CSNK1G31.05863223
55ACVR1B1.00514186
56TIE10.99654183
57LIMK10.98511371
58MAP2K30.97921927
59FER0.95378406
60DDR20.95303274
61CSNK1G20.95155680
62EPHA20.93184881
63TGFBR20.92161728
64CSNK1A1L0.90140477
65CDK70.89546811
66LATS10.89375116
67MAPK150.87805912
68MATK0.86342624
69MAP4K20.85576950
70RPS6KA50.85375831
71MAP2K20.85024504
72BUB10.84897389
73BRAF0.83588031
74GRK50.83185773
75LRRK20.81821071
76DYRK1B0.80737936
77TESK20.80435288
78MAP3K10.80348890
79PRKAA20.80292111
80IKBKE0.79966015
81MAPKAPK30.79579532
82PRPF4B0.77247702
83JAK20.76507508
84FRK0.75969021
85MAP2K60.74212736
86PIM10.71753935
87NEK10.71731988
88DYRK30.70035022
89EIF2AK30.69113785
90RPS6KA40.68775261
91ICK0.67049170
92MAP3K70.63449003
93ZAK0.63260009
94TLK10.63149155
95CAMK2G0.58254094
96MAPK40.57900588
97RPS6KB20.57554988
98ZAP700.55072188
99PLK40.54606887
100TRPM70.54273367
101CDK40.53819361
102WNK40.53800002
103CHUK0.53660274
104MET0.51358730
105PDK10.50908328
106NUAK10.50646237
107PIK3CA0.50332245
108PRKAA10.49745782
109NLK0.48207163
110MELK0.48205676
111PRKACG0.47667585
112IGF1R0.46720643
113CDK60.46492780
114MKNK20.46365906
115BRSK20.45793185
116RIPK10.43952071
117MKNK10.43755840
118LYN0.43475458
119ILK0.43349791
120EPHA30.42795588
121MAPK120.42506985
122ABL10.42347294
123ARAF0.41897001
124MAP3K60.41750978
125SCYL20.41068192
126EPHB20.41011802
127PRKG20.40526408
128MAP2K40.40432455
129GSK3A0.39891013
130NEK20.39597717
131PRKCQ0.38971814
132ERBB20.38616782
133MAP3K80.38198423
134CSF1R0.37955935
135CCNB10.36983280
136CAMK2D0.36962601
137MAP3K50.36648572
138LMTK20.36521201
139CSNK1A10.35939185
140CSNK1G10.34951697
141MAP2K10.34064619
142EGFR0.33909798
143IRAK40.33729582
144MAPK70.33105224
145TEC0.31933589
146CSK0.30688486
147MAP3K100.30034514
148PRKCZ0.29775059
149PDPK10.29588369
150CSNK2A10.29274758
151MAPK30.28959644
152IRAK10.28198778
153OBSCN0.27284690

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.73017404
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10722609
3Steroid hormone biosynthesis_Homo sapiens_hsa001402.90720988
4Fatty acid degradation_Homo sapiens_hsa000712.79635494
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78096324
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63325577
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62061434
8Nitrogen metabolism_Homo sapiens_hsa009102.51310796
9Tryptophan metabolism_Homo sapiens_hsa003802.42324549
10Arginine biosynthesis_Homo sapiens_hsa002202.38749182
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35936450
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34149163
13Propanoate metabolism_Homo sapiens_hsa006402.31456649
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30148797
15Lysosome_Homo sapiens_hsa041422.29926016
16Peroxisome_Homo sapiens_hsa041462.16560047
17Complement and coagulation cascades_Homo sapiens_hsa046102.12246973
18Butanoate metabolism_Homo sapiens_hsa006502.04116811
19Fatty acid metabolism_Homo sapiens_hsa012122.01215151
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00166980
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99498814
22Other glycan degradation_Homo sapiens_hsa005111.98557846
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87422642
24Chemical carcinogenesis_Homo sapiens_hsa052041.86320723
25PPAR signaling pathway_Homo sapiens_hsa033201.84224643
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.80045394
27Folate biosynthesis_Homo sapiens_hsa007901.72860175
28Caffeine metabolism_Homo sapiens_hsa002321.69538029
29beta-Alanine metabolism_Homo sapiens_hsa004101.69171471
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68379075
31Rheumatoid arthritis_Homo sapiens_hsa053231.68096815
32Pyruvate metabolism_Homo sapiens_hsa006201.66868775
33Sulfur metabolism_Homo sapiens_hsa009201.63679105
34Selenocompound metabolism_Homo sapiens_hsa004501.60237990
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58777162
36Histidine metabolism_Homo sapiens_hsa003401.58644516
37Retinol metabolism_Homo sapiens_hsa008301.57343560
38Carbon metabolism_Homo sapiens_hsa012001.52246817
39Tyrosine metabolism_Homo sapiens_hsa003501.47536808
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45840350
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43488488
42Sulfur relay system_Homo sapiens_hsa041221.43487697
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.41888056
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36097286
45Fat digestion and absorption_Homo sapiens_hsa049751.35359356
46Fatty acid elongation_Homo sapiens_hsa000621.33333830
47Biosynthesis of amino acids_Homo sapiens_hsa012301.30888249
48Phenylalanine metabolism_Homo sapiens_hsa003601.26675388
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25614652
50Bile secretion_Homo sapiens_hsa049761.19035358
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18065814
52Starch and sucrose metabolism_Homo sapiens_hsa005001.17886542
53Staphylococcus aureus infection_Homo sapiens_hsa051501.17537962
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13635496
55Sphingolipid metabolism_Homo sapiens_hsa006001.11622250
56Glutathione metabolism_Homo sapiens_hsa004801.09902873
57Vitamin B6 metabolism_Homo sapiens_hsa007501.08478810
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.07761784
59Steroid biosynthesis_Homo sapiens_hsa001001.06026883
60Collecting duct acid secretion_Homo sapiens_hsa049661.05901788
61Vitamin digestion and absorption_Homo sapiens_hsa049771.05870789
62Asthma_Homo sapiens_hsa053101.03199227
63Arginine and proline metabolism_Homo sapiens_hsa003300.94624414
64Ovarian steroidogenesis_Homo sapiens_hsa049130.93474194
65Pentose phosphate pathway_Homo sapiens_hsa000300.91337918
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.90719397
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89997631
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88743925
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87662284
70Legionellosis_Homo sapiens_hsa051340.86028058
71Pertussis_Homo sapiens_hsa051330.83493254
72ABC transporters_Homo sapiens_hsa020100.82914522
73Mineral absorption_Homo sapiens_hsa049780.81144550
74Allograft rejection_Homo sapiens_hsa053300.80998861
75Phagosome_Homo sapiens_hsa041450.79972924
76Fatty acid biosynthesis_Homo sapiens_hsa000610.78926403
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.75644209
78One carbon pool by folate_Homo sapiens_hsa006700.74098765
79Glycerolipid metabolism_Homo sapiens_hsa005610.73147625
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.72503682
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72285822
82Metabolic pathways_Homo sapiens_hsa011000.69603127
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68697379
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64241723
85Graft-versus-host disease_Homo sapiens_hsa053320.62628552
86Tuberculosis_Homo sapiens_hsa051520.62519836
87Type I diabetes mellitus_Homo sapiens_hsa049400.59240890
88Autoimmune thyroid disease_Homo sapiens_hsa053200.58501971
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58408813
90Leishmaniasis_Homo sapiens_hsa051400.57714076
91Vibrio cholerae infection_Homo sapiens_hsa051100.57711842
92Lysine degradation_Homo sapiens_hsa003100.57286062
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56830434
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56704783
95Ribosome_Homo sapiens_hsa030100.56012702
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54320614
97Antigen processing and presentation_Homo sapiens_hsa046120.51794625
98TNF signaling pathway_Homo sapiens_hsa046680.50593633
99Oxidative phosphorylation_Homo sapiens_hsa001900.49658063
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47643282
101Galactose metabolism_Homo sapiens_hsa000520.47547698
102Osteoclast differentiation_Homo sapiens_hsa043800.46556216
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45680508
104Parkinsons disease_Homo sapiens_hsa050120.45272243
105Fructose and mannose metabolism_Homo sapiens_hsa000510.45195686
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44406221
107Salmonella infection_Homo sapiens_hsa051320.43423921
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40743684
109Hepatitis C_Homo sapiens_hsa051600.37454084
110Linoleic acid metabolism_Homo sapiens_hsa005910.37163651
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37056537
112Toxoplasmosis_Homo sapiens_hsa051450.36789760
113Proteasome_Homo sapiens_hsa030500.35612758
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33463277
115Pyrimidine metabolism_Homo sapiens_hsa002400.32867162
116Protein export_Homo sapiens_hsa030600.30207488
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21768331
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.19272567
119Huntingtons disease_Homo sapiens_hsa050160.18968882
120Alzheimers disease_Homo sapiens_hsa050100.17021537
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.13876200
122Insulin resistance_Homo sapiens_hsa049310.13097251
123Arachidonic acid metabolism_Homo sapiens_hsa005900.13043782
124Prion diseases_Homo sapiens_hsa050200.12973107
125Regulation of autophagy_Homo sapiens_hsa041400.07737109
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07197324
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05004353
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03044545
129Renin-angiotensin system_Homo sapiens_hsa046140.02765658
130Glucagon signaling pathway_Homo sapiens_hsa049220.02116195
131AMPK signaling pathway_Homo sapiens_hsa041520.00032627
132Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1310817
133Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1206548
134N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0760277
135RNA polymerase_Homo sapiens_hsa03020-0.0531008
136Purine metabolism_Homo sapiens_hsa00230-0.0299074

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