ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.37351019
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.87718092
3	regulation of mitochondrial translation (GO:0070129)	5.52246596
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.40268809
5	ATP synthesis coupled proton transport (GO:0015986)	5.40268809
6	ribosomal small subunit biogenesis (GO:0042274)	5.19239791
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.13421396
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.11722553
9	respiratory electron transport chain (GO:0022904)	4.83176942
10	electron transport chain (GO:0022900)	4.72100201
11	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.70625201
12	protein targeting to mitochondrion (GO:0006626)	4.59741484
13	protein complex biogenesis (GO:0070271)	4.51270962
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.36550664
15	termination of RNA polymerase III transcription (GO:0006386)	4.36550664
16	establishment of protein localization to mitochondrion (GO:0072655)	4.32849921
17	protein maturation by protein folding (GO:0022417)	4.30249393
18	maturation of SSU-rRNA (GO:0030490)	4.30078692
19	mitochondrial respiratory chain complex assembly (GO:0033108)	4.29037032
20	pseudouridine synthesis (GO:0001522)	4.24082498
21	proteasome assembly (GO:0043248)	4.23142384
22	protein localization to mitochondrion (GO:0070585)	4.10535768
23	peptidyl-arginine omega-N-methylation (GO:0035247)	4.02952735
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.02079534
25	NADH dehydrogenase complex assembly (GO:0010257)	4.02079534
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.02079534
27	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.95743759
28	viral transcription (GO:0019083)	3.84579733
29	metallo-sulfur cluster assembly (GO:0031163)	3.79799615
30	iron-sulfur cluster assembly (GO:0016226)	3.79799615
31	oxidative phosphorylation (GO:0006119)	3.76806376
32	histone arginine methylation (GO:0034969)	3.71513677
33	rRNA modification (GO:0000154)	3.70918818
34	peptidyl-histidine modification (GO:0018202)	3.70617328
35	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.68666413
36	cellular component biogenesis (GO:0044085)	3.65372724
37	translational termination (GO:0006415)	3.65332244
38	ribosomal small subunit assembly (GO:0000028)	3.61173703
39	ribonucleoprotein complex biogenesis (GO:0022613)	3.54234397
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.54098470
41	translation (GO:0006412)	3.52740955
42	guanosine-containing compound biosynthetic process (GO:1901070)	3.52735281
43	ribosomal large subunit biogenesis (GO:0042273)	3.52154137
44	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.51452586
45	respiratory chain complex IV assembly (GO:0008535)	3.51015466
46	GDP-mannose metabolic process (GO:0019673)	3.50598375
47	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.49727135
48	negative regulation of ligase activity (GO:0051352)	3.49727135
49	cytochrome complex assembly (GO:0017004)	3.49698981
50	translational elongation (GO:0006414)	3.48234621
51	cotranslational protein targeting to membrane (GO:0006613)	3.48175821
52	regulation of cellular amino acid metabolic process (GO:0006521)	3.45833551
53	protein targeting to ER (GO:0045047)	3.44471825
54	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.43748316
55	ATP biosynthetic process (GO:0006754)	3.42085862
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.40645583
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.39792734
58	protein localization to endoplasmic reticulum (GO:0070972)	3.35902415
59	GTP biosynthetic process (GO:0006183)	3.32531162
60	mitochondrial transport (GO:0006839)	3.30082655
61	rRNA processing (GO:0006364)	3.28507633
62	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.28176819
63	protein deneddylation (GO:0000338)	3.27150252
64	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.26087109
65	protein-cofactor linkage (GO:0018065)	3.25671417
66	peptidyl-arginine N-methylation (GO:0035246)	3.23161227
67	peptidyl-arginine methylation (GO:0018216)	3.23161227
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.21790035
69	protein neddylation (GO:0045116)	3.19690916
70	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.19612908
71	ATP hydrolysis coupled proton transport (GO:0015991)	3.19612908
72	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.17815225
73	spliceosomal snRNP assembly (GO:0000387)	3.15115860
74	cullin deneddylation (GO:0010388)	3.14911489
75	viral life cycle (GO:0019058)	3.14016799
76	rRNA metabolic process (GO:0016072)	3.11506533
77	base-excision repair, AP site formation (GO:0006285)	3.10140571
78	deoxyribose phosphate biosynthetic process (GO:0046385)	3.09597732
79	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.09597732
80	UTP biosynthetic process (GO:0006228)	3.09404245
81	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.09188982
82	purine nucleotide salvage (GO:0032261)	3.08734553
83	7-methylguanosine mRNA capping (GO:0006370)	3.07519855
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.07007368
85	hydrogen ion transmembrane transport (GO:1902600)	3.06982983
86	ribosome biogenesis (GO:0042254)	3.06685824
87	DNA deamination (GO:0045006)	3.06632167
88	nucleotide salvage (GO:0043173)	3.06081567
89	intracellular protein transmembrane import (GO:0044743)	3.04828882
90	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.02512059
91	nucleoside salvage (GO:0043174)	3.02220679
92	nucleoside triphosphate biosynthetic process (GO:0009142)	3.01989694
93	7-methylguanosine RNA capping (GO:0009452)	2.96982234
94	RNA capping (GO:0036260)	2.96982234
95	positive regulation of ligase activity (GO:0051351)	2.96670379
96	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.96441792
97	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.96441792
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.96218578
99	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.96218578
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.96218578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.19789327
2	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.15194667
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.86557100
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.46414391
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.45531288
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.40088202
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.35213562
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.27990155
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.23490539
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.04343600
11	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.93046684
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.90764645
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86047601
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.73666896
15	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.55262561
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.50339124
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.48467726
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.34305121
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.33338885
20	DCP1A_22483619_ChIP-Seq_HELA_Human	2.31666591
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.28946076
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.27313610
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25643709
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.25050265
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.23914351
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.16805855
27	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.15578417
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.11320636
29	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.96916227
30	ZNF263_19887448_ChIP-Seq_K562_Human	1.91965630
31	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.91363453
32	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.87350568
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.84448153
34	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.84419589
35	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83626140
36	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.82931164
37	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.82650819
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.76977640
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74018029
40	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.67023604
41	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.62378507
42	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.60660157
43	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.58237211
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.51823147
45	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.49838411
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46583178
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43084245
48	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.42268453
49	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.38019305
50	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.35724125
51	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35287377
52	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.35242655
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.33996452
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33791029
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30585238
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30127032
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28204080
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27050720
59	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.25489451
60	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.24190459
61	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.23501917
62	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.20457154
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.18881124
64	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16538299
65	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.14750783
66	LXR_22292898_ChIP-Seq_THP-1_Human	1.13865059
67	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12917334
68	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.11739298
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.11707256
70	P68_20966046_ChIP-Seq_HELA_Human	1.11264035
71	E2F7_22180533_ChIP-Seq_HELA_Human	1.11034066
72	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10993434
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08999613
74	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07784732
75	TFEB_21752829_ChIP-Seq_HELA_Human	1.07323030
76	BCL6_27268052_Chip-Seq_Bcells_Human	1.07096600
77	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07049764
78	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.06405830
79	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.04414347
80	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.04289318
81	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.03546720
82	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00304985
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00203370
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99347138
85	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.99084319
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.98381839
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97078887
88	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.96543602
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.96040650
90	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94268899
91	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93551944
92	VDR_21846776_ChIP-Seq_THP-1_Human	0.92615161
93	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.92117051
94	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91926259
95	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.91476648
96	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.89999598
97	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.88838362
98	PHF8_20622854_ChIP-Seq_HELA_Human	0.88430736
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.88067135
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87887297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.10364027
2	MP0006292_abnormal_olfactory_placode	3.51663689
3	MP0003186_abnormal_redox_activity	3.06669279
4	MP0006036_abnormal_mitochondrial_physio	2.97970256
5	MP0002736_abnormal_nociception_after	2.54373997
6	MP0001905_abnormal_dopamine_level	2.47995448
7	MP0009379_abnormal_foot_pigmentation	2.44522434
8	MP0008932_abnormal_embryonic_tissue	2.43690228
9	MP0003123_paternal_imprinting	2.24633322
10	MP0003693_abnormal_embryo_hatching	2.12397370
11	MP0000049_abnormal_middle_ear	2.09480585
12	MP0009046_muscle_twitch	2.09101524
13	MP0004859_abnormal_synaptic_plasticity	2.08663628
14	MP0006035_abnormal_mitochondrial_morpho	2.06444931
15	MP0005058_abnormal_lysosome_morphology	2.05707634
16	MP0001968_abnormal_touch/_nociception	2.03445490
17	MP0003111_abnormal_nucleus_morphology	1.98887391
18	MP0008058_abnormal_DNA_repair	1.98422634
19	MP0001529_abnormal_vocalization	1.90486475
20	MP0010030_abnormal_orbit_morphology	1.90437703
21	MP0000372_irregular_coat_pigmentation	1.82725372
22	MP0003786_premature_aging	1.82408873
23	MP0002163_abnormal_gland_morphology	1.67917331
24	MP0003880_abnormal_central_pattern	1.61336279
25	MP0004957_abnormal_blastocyst_morpholog	1.59333809
26	MP0000358_abnormal_cell_content/	1.56324252
27	MP0008789_abnormal_olfactory_epithelium	1.54306673
28	MP0003718_maternal_effect	1.45084759
29	MP0008260_abnormal_autophagy	1.40348591
30	MP0005257_abnormal_intraocular_pressure	1.38046058
31	MP0003329_amyloid_beta_deposits	1.37381252
32	MP0002160_abnormal_reproductive_system	1.35758507
33	MP0003077_abnormal_cell_cycle	1.35025028
34	MP0005332_abnormal_amino_acid	1.34348410
35	MP0009745_abnormal_behavioral_response	1.32597867
36	MP0001764_abnormal_homeostasis	1.32291854
37	MP0000678_abnormal_parathyroid_gland	1.31922615
38	MP0003938_abnormal_ear_development	1.29184333
39	MP0000750_abnormal_muscle_regeneration	1.28943267
40	MP0002837_dystrophic_cardiac_calcinosis	1.28180828
41	MP0009697_abnormal_copulation	1.26244822
42	MP0002064_seizures	1.23171738
43	MP0005451_abnormal_body_composition	1.22892564
44	MP0005394_taste/olfaction_phenotype	1.17782958
45	MP0005499_abnormal_olfactory_system	1.17782958
46	MP0002653_abnormal_ependyma_morphology	1.16237106
47	MP0002272_abnormal_nervous_system	1.14777923
48	MP0004147_increased_porphyrin_level	1.11984992
49	MP0009840_abnormal_foam_cell	1.08976442
50	MP0005423_abnormal_somatic_nervous	1.08646152
51	MP0005501_abnormal_skin_physiology	1.08437597
52	MP0001188_hyperpigmentation	1.08341454
53	MP0000681_abnormal_thyroid_gland	1.04102583
54	MP0005379_endocrine/exocrine_gland_phen	1.03563253
55	MP0006276_abnormal_autonomic_nervous	1.02952965
56	MP0004133_heterotaxia	1.01739671
57	MP0000343_altered_response_to	1.00188663
58	MP0005389_reproductive_system_phenotype	0.98875839
59	MP0002734_abnormal_mechanical_nocicepti	0.98386031
60	MP0002876_abnormal_thyroid_physiology	0.98178901
61	MP0001502_abnormal_circadian_rhythm	0.97726164
62	MP0003137_abnormal_impulse_conducting	0.97123594
63	MP0002234_abnormal_pharynx_morphology	0.96727356
64	MP0001542_abnormal_bone_strength	0.96722760
65	MP0008875_abnormal_xenobiotic_pharmacok	0.95559203
66	MP0010094_abnormal_chromosome_stability	0.94896535
67	MP0001970_abnormal_pain_threshold	0.93940219
68	MP0003635_abnormal_synaptic_transmissio	0.93174763
69	MP0004233_abnormal_muscle_weight	0.93057517
70	MP0008007_abnormal_cellular_replicative	0.91126868
71	MP0005171_absent_coat_pigmentation	0.89437176
72	MP0000749_muscle_degeneration	0.89122236
73	MP0001881_abnormal_mammary_gland	0.87989466
74	MP0002822_catalepsy	0.87723391
75	MP0005330_cardiomyopathy	0.86656162
76	MP0000015_abnormal_ear_pigmentation	0.84610861
77	MP0002733_abnormal_thermal_nociception	0.82673828
78	MP0005670_abnormal_white_adipose	0.79589066
79	MP0005646_abnormal_pituitary_gland	0.79576858
80	MP0002210_abnormal_sex_determination	0.78866155
81	MP0000538_abnormal_urinary_bladder	0.78400882
82	MP0002177_abnormal_outer_ear	0.77620617
83	MP0001853_heart_inflammation	0.77265436
84	MP0000003_abnormal_adipose_tissue	0.76955653
85	MP0002572_abnormal_emotion/affect_behav	0.76457688
86	MP0002090_abnormal_vision	0.75679071
87	MP0001984_abnormal_olfaction	0.75354389
88	MP0003879_abnormal_hair_cell	0.75096885
89	MP0001727_abnormal_embryo_implantation	0.74432813
90	MP0005636_abnormal_mineral_homeostasis	0.74253206
91	MP0005623_abnormal_meninges_morphology	0.74148379
92	MP0001919_abnormal_reproductive_system	0.73484592
93	MP0002877_abnormal_melanocyte_morpholog	0.72992090
94	MP0002095_abnormal_skin_pigmentation	0.68268749
95	MP0000013_abnormal_adipose_tissue	0.68023101
96	MP0000313_abnormal_cell_death	0.67652182
97	MP0002938_white_spotting	0.67058933
98	MP0000639_abnormal_adrenal_gland	0.66403059
99	MP0001293_anophthalmia	0.66047694
100	MP0000747_muscle_weakness	0.66027732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	5.93708122
2	Acute necrotizing encephalopathy (HP:0006965)	5.89058085
3	Mitochondrial inheritance (HP:0001427)	5.44881824
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.32479211
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.32479211
6	Acute encephalopathy (HP:0006846)	5.04918039
7	Increased CSF lactate (HP:0002490)	4.99139891
8	Hepatocellular necrosis (HP:0001404)	4.93250283
9	Progressive macrocephaly (HP:0004481)	4.73947591
10	Hepatic necrosis (HP:0002605)	4.52111428
11	Increased intramyocellular lipid droplets (HP:0012240)	4.24794562
12	Increased hepatocellular lipid droplets (HP:0006565)	4.21523931
13	Renal Fanconi syndrome (HP:0001994)	3.83518686
14	Lactic acidosis (HP:0003128)	3.82260870
15	Increased serum lactate (HP:0002151)	3.80657500
16	Cerebral edema (HP:0002181)	3.79176674
17	Lipid accumulation in hepatocytes (HP:0006561)	3.78942845
18	Increased muscle lipid content (HP:0009058)	3.62739635
19	Increased serum pyruvate (HP:0003542)	3.60062307
20	Abnormality of glycolysis (HP:0004366)	3.53127042
21	Exercise intolerance (HP:0003546)	3.44819899
22	Respiratory failure (HP:0002878)	3.36220388
23	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.17942822
24	Testicular atrophy (HP:0000029)	3.12937301
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.08255529
26	3-Methylglutaconic aciduria (HP:0003535)	3.07927495
27	Abnormality of cells of the erythroid lineage (HP:0012130)	3.02328973
28	Abnormal number of erythroid precursors (HP:0012131)	3.00052036
29	Cerebral hypomyelination (HP:0006808)	2.93124806
30	Microretrognathia (HP:0000308)	2.73967527
31	Hypokinesia (HP:0002375)	2.73527977
32	Emotional lability (HP:0000712)	2.72757452
33	Exertional dyspnea (HP:0002875)	2.67870734
34	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64314814
35	Myokymia (HP:0002411)	2.62469362
36	Progressive microcephaly (HP:0000253)	2.57605843
37	Leukodystrophy (HP:0002415)	2.51362877
38	Abnormality of alanine metabolism (HP:0010916)	2.49956533
39	Hyperalaninemia (HP:0003348)	2.49956533
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49956533
41	Respiratory difficulties (HP:0002880)	2.48101165
42	Optic disc pallor (HP:0000543)	2.47597546
43	Type I transferrin isoform profile (HP:0003642)	2.46582880
44	Ragged-red muscle fibers (HP:0003200)	2.44849493
45	Rough bone trabeculation (HP:0100670)	2.41186023
46	Lethargy (HP:0001254)	2.39763351
47	Progressive muscle weakness (HP:0003323)	2.39637115
48	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.39211478
49	CNS demyelination (HP:0007305)	2.38998710
50	Microvesicular hepatic steatosis (HP:0001414)	2.38077107
51	Methylmalonic aciduria (HP:0012120)	2.34141935
52	Macrocytic anemia (HP:0001972)	2.31458721
53	Reticulocytopenia (HP:0001896)	2.20651642
54	Abnormality of magnesium homeostasis (HP:0004921)	2.18951469
55	Opisthotonus (HP:0002179)	2.17991759
56	Redundant skin (HP:0001582)	2.12999015
57	Abnormal protein glycosylation (HP:0012346)	2.11797067
58	Abnormal glycosylation (HP:0012345)	2.11797067
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.11797067
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.11797067
61	Poor head control (HP:0002421)	2.10177382
62	X-linked dominant inheritance (HP:0001423)	2.07473641
63	Prolonged neonatal jaundice (HP:0006579)	2.06358163
64	Hyperthyroidism (HP:0000836)	2.05616608
65	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.03144988
66	Delusions (HP:0000746)	2.00474729
67	Gliosis (HP:0002171)	1.98549652
68	Aplastic anemia (HP:0001915)	1.97362763
69	Reduced antithrombin III activity (HP:0001976)	1.94857181
70	Generalized aminoaciduria (HP:0002909)	1.94558954
71	Death in infancy (HP:0001522)	1.90911701
72	Poor suck (HP:0002033)	1.89123780
73	Abnormality of renal resorption (HP:0011038)	1.85767277
74	Glycosuria (HP:0003076)	1.79922929
75	Abnormality of urine glucose concentration (HP:0011016)	1.79922929
76	CNS hypomyelination (HP:0003429)	1.79785465
77	Sparse eyelashes (HP:0000653)	1.78385536
78	Abnormal trabecular bone morphology (HP:0100671)	1.77331945
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76445128
80	Hypoplastic left heart (HP:0004383)	1.72754832
81	Progressive neurologic deterioration (HP:0002344)	1.72644401
82	Cleft eyelid (HP:0000625)	1.72482089
83	Down-sloping shoulders (HP:0200021)	1.71967632
84	Dicarboxylic aciduria (HP:0003215)	1.71415384
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.71415384
86	Pancytopenia (HP:0001876)	1.71371344
87	Hypoplasia of the uterus (HP:0000013)	1.70918125
88	Blindness (HP:0000618)	1.70908686
89	Multiple enchondromatosis (HP:0005701)	1.70844145
90	Cholecystitis (HP:0001082)	1.69695133
91	Abnormal gallbladder physiology (HP:0012438)	1.69695133
92	Spastic paraparesis (HP:0002313)	1.68890632
93	Vacuolated lymphocytes (HP:0001922)	1.67697421
94	Methylmalonic acidemia (HP:0002912)	1.66709864
95	Cortical visual impairment (HP:0100704)	1.63643603
96	Truncus arteriosus (HP:0001660)	1.62275313
97	Hypoplastic pelvis (HP:0008839)	1.61643459
98	Broad distal phalanx of finger (HP:0009836)	1.60798260
99	Vomiting (HP:0002013)	1.60776911
100	Hyperphosphaturia (HP:0003109)	1.60713415

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.18511514
2	VRK2	4.85691255
3	BCKDK	4.06085172
4	BUB1	3.90979824
5	TESK2	2.89137643
6	TESK1	2.87097192
7	ARAF	2.66594305
8	LIMK1	2.65047659
9	STK16	2.64653253
10	PIM2	2.25948248
11	ABL2	2.09173244
12	NME1	2.07178518
13	IRAK3	1.97008002
14	CSNK1G3	1.92504798
15	MAP2K7	1.71921026
16	TLK1	1.67035545
17	PDK2	1.63473377
18	DAPK1	1.63016958
19	MAP3K11	1.60671464
20	EIF2AK1	1.59838189
21	CSNK1G2	1.44977069
22	AURKA	1.41248110
23	SMG1	1.41067354
24	CSNK1A1L	1.38153529
25	SRPK1	1.33685936
26	VRK1	1.30280195
27	CSNK1G1	1.26156569
28	PHKG2	1.25333503
29	PHKG1	1.25333503
30	KDR	1.20750342
31	PBK	1.18964865
32	ZAK	1.18607619
33	DYRK2	1.13514954
34	CDC7	1.13459184
35	GRK5	1.13186365
36	BRAF	1.13121460
37	NEK1	1.12878446
38	BRSK1	1.08524584
39	PRKCI	1.07290544
40	PRKD3	1.02894614
41	DAPK3	1.01072772
42	PINK1	0.95893064
43	MAP3K12	0.92834328
44	PLK1	0.92260424
45	MAPKAPK3	0.92078276
46	ILK	0.89936420
47	EPHA2	0.88286664
48	PAK6	0.86083079
49	CAMK2G	0.85387193
50	CCNB1	0.84109152
51	CHEK2	0.75752516
52	CDK14	0.75003332
53	TAF1	0.74606642
54	SCYL2	0.74063397
55	WNK4	0.72761212
56	CDK11A	0.71445814
57	CDK15	0.70378840
58	AURKB	0.68790177
59	PAK4	0.68663569
60	CDK18	0.68632915
61	RPS6KA5	0.67128396
62	MAP4K2	0.65736854
63	TAOK2	0.65445780
64	RPS6KA4	0.64276489
65	PLK3	0.63331047
66	PAK1	0.62747353
67	EPHB2	0.62398058
68	EPHA4	0.61687766
69	MAPKAPK5	0.58114021
70	CDK8	0.57326992
71	DYRK3	0.57201822
72	CSNK2A1	0.54446421
73	PLK2	0.54359906
74	PRKCG	0.52411907
75	CAMK2B	0.52170638
76	CDK7	0.50460617
77	CAMK2D	0.49451511
78	LMTK2	0.49442638
79	CSNK2A2	0.49281790
80	TTK	0.45148394
81	MINK1	0.44206365
82	MYLK	0.41184814
83	EIF2AK2	0.40645286
84	MST1R	0.39490920
85	CAMKK2	0.38173194
86	GRK7	0.37446741
87	PRKG2	0.36924753
88	MOS	0.36837875
89	NUAK1	0.36602823
90	AKT2	0.35979958
91	PLK4	0.35533434
92	ERBB4	0.34924281
93	MUSK	0.32703634
94	MAP2K2	0.32567857
95	CSNK1A1	0.32471688
96	PKN1	0.31741321
97	LRRK2	0.31379481
98	MAP2K6	0.29864108
99	CDK19	0.28949018
100	PTK2	0.28235475

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.31830709
2	Ribosome_Homo sapiens_hsa03010	4.19666850
3	Proteasome_Homo sapiens_hsa03050	3.90545410
4	Sulfur relay system_Homo sapiens_hsa04122	3.72518194
5	Parkinsons disease_Homo sapiens_hsa05012	3.61775597
6	RNA polymerase_Homo sapiens_hsa03020	3.07700031
7	DNA replication_Homo sapiens_hsa03030	2.73533821
8	Huntingtons disease_Homo sapiens_hsa05016	2.62937314
9	Alzheimers disease_Homo sapiens_hsa05010	2.50950558
10	Base excision repair_Homo sapiens_hsa03410	2.22186963
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.15139011
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.15130139
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.07875268
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.05479834
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.87519297
16	Folate biosynthesis_Homo sapiens_hsa00790	1.85603466
17	Mismatch repair_Homo sapiens_hsa03430	1.85287350
18	Fatty acid elongation_Homo sapiens_hsa00062	1.74102120
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65304156
20	Sulfur metabolism_Homo sapiens_hsa00920	1.64308171
21	Protein export_Homo sapiens_hsa03060	1.64100200
22	Homologous recombination_Homo sapiens_hsa03440	1.62954320
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.57952010
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.54565310
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.54304404
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46337973
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.37921673
28	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.37219538
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35893657
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35248614
31	Vibrio cholerae infection_Homo sapiens_hsa05110	1.32212466
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.28527997
33	Glutathione metabolism_Homo sapiens_hsa00480	1.26176999
34	Purine metabolism_Homo sapiens_hsa00230	1.23539566
35	Spliceosome_Homo sapiens_hsa03040	1.22647755
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.20719096
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.20225483
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17820589
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10441795
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.05479883
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00881183
42	RNA transport_Homo sapiens_hsa03013	1.00213297
43	Basal transcription factors_Homo sapiens_hsa03022	0.99942663
44	Carbon metabolism_Homo sapiens_hsa01200	0.98664910
45	One carbon pool by folate_Homo sapiens_hsa00670	0.97075409
46	Metabolic pathways_Homo sapiens_hsa01100	0.95341151
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94986773
48	Galactose metabolism_Homo sapiens_hsa00052	0.93793501
49	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.92842074
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89786169
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89551709
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.80995471
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77807160
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75912304
55	Peroxisome_Homo sapiens_hsa04146	0.75413955
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72521142
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.69388642
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.68982287
59	RNA degradation_Homo sapiens_hsa03018	0.68702698
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.68094705
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.67484819
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65469775
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61913562
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61563400
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60162021
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56997239
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.52012374
68	Lysosome_Homo sapiens_hsa04142	0.49735753
69	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.46091721
70	Propanoate metabolism_Homo sapiens_hsa00640	0.41901284
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40742656
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38814836
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.37314823
74	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.37110992
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35215823
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.32780350
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.32184400
78	p53 signaling pathway_Homo sapiens_hsa04115	0.31850879
79	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.31845895
80	Other glycan degradation_Homo sapiens_hsa00511	0.31018211
81	Cell cycle_Homo sapiens_hsa04110	0.27674176
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.27623587
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26253199
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.25208803
85	Oocyte meiosis_Homo sapiens_hsa04114	0.23639076
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.21901194
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.21539424
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.21364788
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.19766444
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.18336601
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18139667
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.17319596
93	Nicotine addiction_Homo sapiens_hsa05033	0.16124389
94	Mineral absorption_Homo sapiens_hsa04978	0.15335638
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.15159282
96	Regulation of autophagy_Homo sapiens_hsa04140	0.13428290
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.13022735
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.11811674
99	Butanoate metabolism_Homo sapiens_hsa00650	0.11396694
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.10577580

FDX2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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