FDXACB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.35545916
2piRNA metabolic process (GO:0034587)4.09178241
3superoxide anion generation (GO:0042554)4.08905446
4negative regulation of telomere maintenance (GO:0032205)4.03315928
5meiotic chromosome segregation (GO:0045132)3.68333933
6pseudouridine synthesis (GO:0001522)3.67789070
7maturation of 5.8S rRNA (GO:0000460)3.64677632
8cullin deneddylation (GO:0010388)3.60429052
9daunorubicin metabolic process (GO:0044597)3.60179724
10polyketide metabolic process (GO:0030638)3.60179724
11doxorubicin metabolic process (GO:0044598)3.60179724
12behavioral response to nicotine (GO:0035095)3.59747388
13kinetochore assembly (GO:0051382)3.56862295
14protein complex biogenesis (GO:0070271)3.54557056
15response to pheromone (GO:0019236)3.51534344
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49901571
17water-soluble vitamin biosynthetic process (GO:0042364)3.48930792
18protein-cofactor linkage (GO:0018065)3.48712889
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.48054146
20NADH dehydrogenase complex assembly (GO:0010257)3.48054146
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48054146
22protein deneddylation (GO:0000338)3.47473288
23protein neddylation (GO:0045116)3.42423630
24regulation of activation of Janus kinase activity (GO:0010533)3.42393075
25negative regulation of mast cell activation (GO:0033004)3.41689933
26kinetochore organization (GO:0051383)3.38694846
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36895814
28kynurenine metabolic process (GO:0070189)3.36343141
29mannosylation (GO:0097502)3.34951091
30platelet dense granule organization (GO:0060155)3.34193815
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33438380
32mitochondrial respiratory chain complex assembly (GO:0033108)3.31811599
33positive regulation of cellular amide metabolic process (GO:0034250)3.31006478
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.29846019
35energy homeostasis (GO:0097009)3.26624040
36detection of other organism (GO:0098543)3.23806732
37fucose catabolic process (GO:0019317)3.23021989
38L-fucose metabolic process (GO:0042354)3.23021989
39L-fucose catabolic process (GO:0042355)3.23021989
40dendritic cell chemotaxis (GO:0002407)3.20034041
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17590078
42ATP synthesis coupled proton transport (GO:0015986)3.17590078
43cellular ketone body metabolic process (GO:0046950)3.14439466
44indole-containing compound catabolic process (GO:0042436)3.13648324
45indolalkylamine catabolic process (GO:0046218)3.13648324
46tryptophan catabolic process (GO:0006569)3.13648324
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11630668
48positive regulation of mitochondrial fission (GO:0090141)3.10827388
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09722753
50respiratory chain complex IV assembly (GO:0008535)3.06922545
51cytochrome complex assembly (GO:0017004)3.05461506
52dendritic cell migration (GO:0036336)3.04818233
53mitochondrial RNA metabolic process (GO:0000959)3.04152264
54nucleotide transmembrane transport (GO:1901679)3.03481339
55ubiquinone biosynthetic process (GO:0006744)3.01685527
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00739140
57chaperone-mediated protein transport (GO:0072321)3.00664057
58protein polyglutamylation (GO:0018095)2.96383620
59termination of RNA polymerase III transcription (GO:0006386)2.95687886
60transcription elongation from RNA polymerase III promoter (GO:0006385)2.95687886
61tryptophan metabolic process (GO:0006568)2.94847651
62indolalkylamine metabolic process (GO:0006586)2.93530765
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.89378134
64CENP-A containing nucleosome assembly (GO:0034080)2.88420929
65ketone body metabolic process (GO:1902224)2.88283722
66cell wall macromolecule catabolic process (GO:0016998)2.87445894
67anterograde synaptic vesicle transport (GO:0048490)2.85218861
68reciprocal meiotic recombination (GO:0007131)2.83595548
69reciprocal DNA recombination (GO:0035825)2.83595548
70peptidyl-histidine modification (GO:0018202)2.82465591
71male meiosis I (GO:0007141)2.80923945
72DNA catabolic process, exonucleolytic (GO:0000738)2.80806104
73* tRNA processing (GO:0008033)2.79131023
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78183479
75regulation of mitotic spindle checkpoint (GO:1903504)2.78183479
76regulation of DNA endoreduplication (GO:0032875)2.77441070
77amino acid salvage (GO:0043102)2.76402130
78L-methionine salvage (GO:0071267)2.76402130
79L-methionine biosynthetic process (GO:0071265)2.76402130
80chromatin remodeling at centromere (GO:0031055)2.75619252
81interferon-gamma production (GO:0032609)2.75309267
82regulation of mitochondrial translation (GO:0070129)2.74479063
83ubiquinone metabolic process (GO:0006743)2.73891708
84poly(A)+ mRNA export from nucleus (GO:0016973)2.73160665
85cellular response to interferon-beta (GO:0035458)2.72149811
86kidney morphogenesis (GO:0060993)2.71989231
87DNA synthesis involved in DNA repair (GO:0000731)2.71722744
88inositol phosphate catabolic process (GO:0071545)2.71550725
89detection of bacterium (GO:0016045)2.69921164
90adaptation of signaling pathway (GO:0023058)2.69734298
91histone H2A acetylation (GO:0043968)2.66723401
92positive regulation of interleukin-1 beta secretion (GO:0050718)2.66316447
93DNA ligation (GO:0006266)2.66242527
94protein K6-linked ubiquitination (GO:0085020)2.63740506
95peroxisome fission (GO:0016559)2.63658006
96intracellular protein transmembrane import (GO:0044743)2.62678650
97cell wall macromolecule metabolic process (GO:0044036)2.62312456
98metallo-sulfur cluster assembly (GO:0031163)2.61244973
99iron-sulfur cluster assembly (GO:0016226)2.61244973
100recombinational repair (GO:0000725)2.58864706
101double-strand break repair via homologous recombination (GO:0000724)2.58686498
102regulation of telomere maintenance (GO:0032204)2.58337012
103DNA strand renaturation (GO:0000733)2.57382159
104neutrophil activation involved in immune response (GO:0002283)2.56284694
105DNA integration (GO:0015074)2.54912424
106response to host immune response (GO:0052572)2.54688907
107response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54688907
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54555790
109GPI anchor metabolic process (GO:0006505)2.54522290
110neutrophil activation (GO:0042119)2.54075013
111synapsis (GO:0007129)2.52112298
112positive regulation of antigen processing and presentation (GO:0002579)2.52064880
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52020336
114tRNA modification (GO:0006400)2.51136563
115rRNA methylation (GO:0031167)2.50935265
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.50888340
117C-terminal protein lipidation (GO:0006501)2.50158194
118pyrimidine dimer repair (GO:0006290)2.48947299
119intra-S DNA damage checkpoint (GO:0031573)2.48664892
120regulation of timing of cell differentiation (GO:0048505)2.48375337
121NIK/NF-kappaB signaling (GO:0038061)2.47656377
122detection of molecule of bacterial origin (GO:0032490)2.47257906
123preassembly of GPI anchor in ER membrane (GO:0016254)2.46990100
124phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46836189
125inositol phosphate dephosphorylation (GO:0046855)2.46836189
126superoxide metabolic process (GO:0006801)2.46086494
127detection of light stimulus involved in sensory perception (GO:0050962)2.45942965
128detection of light stimulus involved in visual perception (GO:0050908)2.45942965
129regulation of mitochondrial fission (GO:0090140)2.45837500
130electron transport chain (GO:0022900)2.45367474
131S-adenosylmethionine metabolic process (GO:0046500)2.45366527
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.45118696
133positive regulation of DNA-dependent DNA replication (GO:2000105)2.44983544
134positive regulation of protein homodimerization activity (GO:0090073)2.44697566
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44415656
136T cell lineage commitment (GO:0002360)2.43842652
137hepatocyte differentiation (GO:0070365)2.43260575
138regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42806375
139positive regulation of uterine smooth muscle contraction (GO:0070474)2.42464772
140cilium or flagellum-dependent cell motility (GO:0001539)2.40794543
141DNA methylation involved in gamete generation (GO:0043046)2.40206685
142I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.40069216
143positive regulation of interleukin-1 secretion (GO:0050716)2.39888151
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39239521
145mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39239521
146mismatch repair (GO:0006298)2.39054324
147regulation of interleukin-1 beta secretion (GO:0050706)2.38489563
148germinal center formation (GO:0002467)2.38326960
149negative regulation of viral genome replication (GO:0045071)2.38301687
150cellular response to zinc ion (GO:0071294)2.36830694
151tRNA methylation (GO:0030488)2.34479976
152G-protein coupled receptor internalization (GO:0002031)2.33973391
153rRNA modification (GO:0000154)2.33911275
154regulation of interleukin-8 secretion (GO:2000482)2.33357647
155purine deoxyribonucleotide catabolic process (GO:0009155)2.32805749
156proteasome assembly (GO:0043248)2.31332063
157replicative senescence (GO:0090399)2.30863983
158regulation of development, heterochronic (GO:0040034)2.30700226
159regulation of glucokinase activity (GO:0033131)2.30597522
160regulation of hexokinase activity (GO:1903299)2.30597522
161regulation of antigen processing and presentation (GO:0002577)2.30337676
162positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.28914458
163replication fork processing (GO:0031297)2.28188200
164response to peptidoglycan (GO:0032494)2.26538811
165response to X-ray (GO:0010165)2.26313587
166detection of external biotic stimulus (GO:0098581)2.24308261
167CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.24178729
168DNA double-strand break processing (GO:0000729)2.22507888
169detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.21636356
170positive regulation of T cell mediated cytotoxicity (GO:0001916)2.20322756
171regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.20311615
172regulation of cellular extravasation (GO:0002691)2.19731479
173mature B cell differentiation involved in immune response (GO:0002313)2.19653552
174positive regulation of T cell migration (GO:2000406)2.19134637
175tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.18993959
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.18993959
177positive regulation of gamma-delta T cell activation (GO:0046645)2.18015673
178regulation of MHC class II biosynthetic process (GO:0045346)2.17937589
179positive regulation of heat generation (GO:0031652)2.17780569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.46634230
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32491714
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.08518001
4VDR_22108803_ChIP-Seq_LS180_Human3.06990296
5E2F7_22180533_ChIP-Seq_HELA_Human3.03565276
6GBX2_23144817_ChIP-Seq_PC3_Human2.88489459
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.87210580
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60067623
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54369255
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51038382
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.40132868
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.38688199
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35675776
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.35101366
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.34033206
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.33552120
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.30033714
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24754333
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19491393
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.18891617
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17817358
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16608122
23IGF1R_20145208_ChIP-Seq_DFB_Human2.13119966
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09427606
25MYC_18940864_ChIP-ChIP_HL60_Human2.09333339
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05702116
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.98212319
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97716533
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95290445
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.90373306
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89385968
32P53_22387025_ChIP-Seq_ESCs_Mouse1.85661970
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85140700
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.84848513
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.83979430
36IRF1_19129219_ChIP-ChIP_H3396_Human1.83808382
37EWS_26573619_Chip-Seq_HEK293_Human1.81647626
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81449800
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.74912394
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.73131654
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.72159090
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71861376
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70069523
44TP53_22573176_ChIP-Seq_HFKS_Human1.68900537
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.68790238
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67130955
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66647089
48* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65247819
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.65233430
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63549986
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.62652230
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.59734338
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.58349538
54P300_18555785_Chip-Seq_ESCs_Mouse1.57454796
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57279447
56ZFX_18555785_Chip-Seq_ESCs_Mouse1.56929871
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.55162654
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53895375
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53610700
60ELK1_19687146_ChIP-ChIP_HELA_Human1.53430925
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.51206827
62PU1_27457419_Chip-Seq_LIVER_Mouse1.50987846
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49996549
64P300_19829295_ChIP-Seq_ESCs_Human1.48260138
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47725484
66FUS_26573619_Chip-Seq_HEK293_Human1.46907547
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43144079
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42302630
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.40998414
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40739011
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39361745
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.39083576
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37266588
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36687290
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.36395215
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35700209
77SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35639541
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.35004991
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33546601
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32928101
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32852303
82ER_23166858_ChIP-Seq_MCF-7_Human1.32815087
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32526226
84TAF15_26573619_Chip-Seq_HEK293_Human1.30496587
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30441951
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29899071
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28940508
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.28750665
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28750665
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27676486
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.27500822
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26022021
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.25630856
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25580216
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.25391255
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.22313648
97* NANOG_19829295_ChIP-Seq_ESCs_Human1.22197749
98* SOX2_19829295_ChIP-Seq_ESCs_Human1.22197749
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19717259
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19308182
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18836650
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18623809
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16741952
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.16318424
105SCL_19346495_ChIP-Seq_HPC-7_Human1.15762856
106GABP_19822575_ChIP-Seq_HepG2_Human1.15216493
107VDR_23849224_ChIP-Seq_CD4+_Human1.15085865
108AR_20517297_ChIP-Seq_VCAP_Human1.14990820
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14563246
110RNF2_27304074_Chip-Seq_NSC_Mouse1.13952952
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13845574
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12003587
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11859552
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11104095
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10135910
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10044516
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09254387
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09108977
119CBP_20019798_ChIP-Seq_JUKART_Human1.09108977
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.07735385
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07625276
122DCP1A_22483619_ChIP-Seq_HELA_Human1.06840652
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06597804
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05726264
125NCOR_22424771_ChIP-Seq_293T_Human1.05505441
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05172933
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04439133
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03455933
129AR_25329375_ChIP-Seq_VCAP_Human1.02996967
130BCAT_22108803_ChIP-Seq_LS180_Human1.02304299
131* FOXP3_21729870_ChIP-Seq_TREG_Human1.01218260
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00365323
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00346719
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99800463
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99789401
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99789401
137TCF4_22108803_ChIP-Seq_LS180_Human0.98246702
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98244017
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98037801
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96683717
141GATA3_26560356_Chip-Seq_TH2_Human0.95922442
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95539569
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93312617
144STAT3_23295773_ChIP-Seq_U87_Human0.92862608
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.92476981
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92272362
147HOXB7_26014856_ChIP-Seq_BT474_Human0.91102072
148THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90005948
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89042081
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88441685
151TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85874903
152HTT_18923047_ChIP-ChIP_STHdh_Human0.85798725
153TCF4_23295773_ChIP-Seq_U87_Human0.85393953
154SMAD4_21799915_ChIP-Seq_A2780_Human0.84783783
155MYC_19829295_ChIP-Seq_ESCs_Human0.84775220
156* TTF2_22483619_ChIP-Seq_HELA_Human0.84582999
157ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83981804
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.83942796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.17322830
2MP0006292_abnormal_olfactory_placode3.67497435
3MP0001835_abnormal_antigen_presentation3.32881319
4MP0008058_abnormal_DNA_repair3.29834531
5MP0002132_abnormal_respiratory_system3.14186481
6MP0001188_hyperpigmentation3.04927461
7MP0009697_abnormal_copulation2.42014896
8MP0005551_abnormal_eye_electrophysiolog2.41971280
9MP0003195_calcinosis2.36633855
10MP0003136_yellow_coat_color2.32194179
11MP0009785_altered_susceptibility_to2.29252419
12MP0000566_synostosis2.27756334
13MP0003718_maternal_effect2.24327779
14MP0002148_abnormal_hypersensitivity_rea2.23778085
15MP0002138_abnormal_hepatobiliary_system2.22812192
16MP0010094_abnormal_chromosome_stability2.21825953
17MP0005671_abnormal_response_to2.19173625
18MP0002396_abnormal_hematopoietic_system2.15988912
19MP0008057_abnormal_DNA_replication2.15356644
20MP0000569_abnormal_digit_pigmentation2.10852169
21MP0001986_abnormal_taste_sensitivity2.10794889
22MP0008007_abnormal_cellular_replicative2.05406815
23MP0006072_abnormal_retinal_apoptosis2.05202924
24MP0002277_abnormal_respiratory_mucosa1.99274672
25MP0002163_abnormal_gland_morphology1.99101837
26MP0003787_abnormal_imprinting1.97149930
27MP0002102_abnormal_ear_morphology1.96774746
28MP0008875_abnormal_xenobiotic_pharmacok1.96489672
29MP0008877_abnormal_DNA_methylation1.96257084
30MP0005084_abnormal_gallbladder_morpholo1.95291821
31MP0008872_abnormal_physiological_respon1.94433891
32MP0003724_increased_susceptibility_to1.93053312
33MP0003111_abnormal_nucleus_morphology1.90173432
34MP0005387_immune_system_phenotype1.77577925
35MP0001790_abnormal_immune_system1.77577925
36MP0004885_abnormal_endolymph1.75638072
37MP0005171_absent_coat_pigmentation1.75545733
38MP0006036_abnormal_mitochondrial_physio1.73300021
39MP0000015_abnormal_ear_pigmentation1.72821954
40MP0006035_abnormal_mitochondrial_morpho1.71404835
41MP0005646_abnormal_pituitary_gland1.68992601
42MP0005379_endocrine/exocrine_gland_phen1.68914360
43MP0005025_abnormal_response_to1.66218493
44MP0004142_abnormal_muscle_tone1.63703182
45MP0005409_darkened_coat_color1.62120836
46MP0002419_abnormal_innate_immunity1.61486612
47MP0001968_abnormal_touch/_nociception1.59257300
48MP0001800_abnormal_humoral_immune1.58479640
49MP0005253_abnormal_eye_physiology1.58010001
50MP0002452_abnormal_antigen_presenting1.57090998
51MP0000685_abnormal_immune_system1.56106706
52MP0005000_abnormal_immune_tolerance1.53725986
53MP0003011_delayed_dark_adaptation1.52643890
54MP0000490_abnormal_crypts_of1.50575762
55MP0005174_abnormal_tail_pigmentation1.50057911
56MP0003786_premature_aging1.47463101
57MP0009745_abnormal_behavioral_response1.44843813
58MP0002736_abnormal_nociception_after1.44782673
59MP0002723_abnormal_immune_serum1.44625934
60MP0004133_heterotaxia1.44363686
61MP0002638_abnormal_pupillary_reflex1.43741159
62MP0005075_abnormal_melanosome_morpholog1.43678733
63MP0009764_decreased_sensitivity_to1.42554138
64MP0009046_muscle_twitch1.41579789
65MP0001819_abnormal_immune_cell1.40883334
66MP0003763_abnormal_thymus_physiology1.40529696
67MP0002420_abnormal_adaptive_immunity1.40413640
68MP0003806_abnormal_nucleotide_metabolis1.36957441
69MP0003077_abnormal_cell_cycle1.33411975
70MP0010386_abnormal_urinary_bladder1.29740259
71MP0004147_increased_porphyrin_level1.26978176
72MP0002693_abnormal_pancreas_physiology1.25621048
73MP0002653_abnormal_ependyma_morphology1.25548308
74MP0004808_abnormal_hematopoietic_stem1.25095291
75MP0002398_abnormal_bone_marrow1.21113568
76MP0003436_decreased_susceptibility_to1.20683695
77MP0001929_abnormal_gametogenesis1.18271335
78MP0003693_abnormal_embryo_hatching1.14580237
79MP0004215_abnormal_myocardial_fiber1.14226950
80MP0002095_abnormal_skin_pigmentation1.13984546
81MP0000716_abnormal_immune_system1.13378712
82MP0000516_abnormal_urinary_system1.13012551
83MP0005367_renal/urinary_system_phenotyp1.13012551
84MP0002876_abnormal_thyroid_physiology1.11860807
85MP0005389_reproductive_system_phenotype1.11760713
86MP0002272_abnormal_nervous_system1.10064403
87MP0008995_early_reproductive_senescence1.09709337
88MP0006276_abnormal_autonomic_nervous1.08546352
89MP0001764_abnormal_homeostasis1.08539583
90MP0004043_abnormal_pH_regulation1.07181564
91MP0001853_heart_inflammation1.07180916
92MP0005410_abnormal_fertilization1.04899262
93MP0008775_abnormal_heart_ventricle1.04870948
94MP0000631_abnormal_neuroendocrine_gland1.04838112
95MP0004145_abnormal_muscle_electrophysio1.04747044
96MP0001346_abnormal_lacrimal_gland1.04727573
97MP0005645_abnormal_hypothalamus_physiol0.98662593
98MP0002160_abnormal_reproductive_system0.98402856
99MP0001119_abnormal_female_reproductive0.96400181
100MP0000681_abnormal_thyroid_gland0.96019411
101MP0002405_respiratory_system_inflammati0.95439664
102MP0003698_abnormal_male_reproductive0.95115826
103MP0001919_abnormal_reproductive_system0.94872846
104MP0002938_white_spotting0.94487529
105MP0000689_abnormal_spleen_morphology0.94044352
106MP0001501_abnormal_sleep_pattern0.93826532
107MP0008260_abnormal_autophagy0.93302687
108MP0004381_abnormal_hair_follicle0.93163430
109MP0004742_abnormal_vestibular_system0.92467395
110MP0003646_muscle_fatigue0.92324234
111MP0002429_abnormal_blood_cell0.92000526
112MP0001486_abnormal_startle_reflex0.91514574
113MP0005195_abnormal_posterior_eye0.91219149
114MP0003890_abnormal_embryonic-extraembry0.90923096
115MP0001186_pigmentation_phenotype0.90032684
116MP0002751_abnormal_autonomic_nervous0.89827805
117MP0003943_abnormal_hepatobiliary_system0.88309115
118MP0002234_abnormal_pharynx_morphology0.88266801
119MP0000653_abnormal_sex_gland0.88235719
120MP0001529_abnormal_vocalization0.88165740
121MP0003121_genomic_imprinting0.88014187
122MP0001145_abnormal_male_reproductive0.87552804
123MP0005386_behavior/neurological_phenoty0.87523966
124MP0004924_abnormal_behavior0.87523966
125MP0005332_abnormal_amino_acid0.86746478
126MP0000371_diluted_coat_color0.86203177
127MP0004782_abnormal_surfactant_physiolog0.85447708
128MP0003567_abnormal_fetal_cardiomyocyte0.85375646
129MP0002928_abnormal_bile_duct0.84417561
130MP0000372_irregular_coat_pigmentation0.84126349
131MP0000427_abnormal_hair_cycle0.84043465
132MP0002572_abnormal_emotion/affect_behav0.83582367
133MP0003880_abnormal_central_pattern0.83476647
134MP0002722_abnormal_immune_system0.83116161
135MP0005670_abnormal_white_adipose0.82756842
136MP0002557_abnormal_social/conspecific_i0.82362625
137MP0005395_other_phenotype0.82279805
138MP0001984_abnormal_olfaction0.81460061
139MP0008789_abnormal_olfactory_epithelium0.81393843
140MP0005394_taste/olfaction_phenotype0.81132544
141MP0005499_abnormal_olfactory_system0.81132544
142MP0008004_abnormal_stomach_pH0.81023934
143MP0003186_abnormal_redox_activity0.80198961
144MP0005636_abnormal_mineral_homeostasis0.79191924
145MP0002210_abnormal_sex_determination0.79006116
146MP0001944_abnormal_pancreas_morphology0.78343682
147MP0006082_CNS_inflammation0.76220718
148MP0000026_abnormal_inner_ear0.75792454
149MP0000383_abnormal_hair_follicle0.74726388
150MP0010155_abnormal_intestine_physiology0.74420601
151MP0000858_altered_metastatic_potential0.73977649
152MP0001845_abnormal_inflammatory_respons0.73787286
153MP0002735_abnormal_chemical_nociception0.72738766
154MP0005397_hematopoietic_system_phenotyp0.71913809
155MP0001545_abnormal_hematopoietic_system0.71913809
156MP0002075_abnormal_coat/hair_pigmentati0.71638537
157MP0000678_abnormal_parathyroid_gland0.71103247
158MP0000049_abnormal_middle_ear0.70967633
159MP0001485_abnormal_pinna_reflex0.70303774
160MP0003828_pulmonary_edema0.66446384
161MP0003183_abnormal_peptide_metabolism0.66443912
162MP0000703_abnormal_thymus_morphology0.65062446
163MP0001905_abnormal_dopamine_level0.64363233

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.70684050
2Chromsome breakage (HP:0040012)5.22699639
3Prostate neoplasm (HP:0100787)3.42314798
4Molar tooth sign on MRI (HP:0002419)3.34445785
5Abnormality of midbrain morphology (HP:0002418)3.34445785
6Abnormality of the preputium (HP:0100587)3.14095566
7Duplicated collecting system (HP:0000081)3.11868551
8Abnormality of the renal collecting system (HP:0004742)3.09126595
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.07087175
10Retrobulbar optic neuritis (HP:0100654)3.03903175
11Optic neuritis (HP:0100653)3.03903175
12Mitochondrial inheritance (HP:0001427)2.97195541
13Clubbing of toes (HP:0100760)2.92552324
14Meckel diverticulum (HP:0002245)2.90842079
15Alveolar cell carcinoma (HP:0006519)2.88209087
16Acute necrotizing encephalopathy (HP:0006965)2.87385897
17Increased CSF lactate (HP:0002490)2.87385354
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.81450578
19Hepatocellular necrosis (HP:0001404)2.78327923
20Nephronophthisis (HP:0000090)2.76688178
21Lipid accumulation in hepatocytes (HP:0006561)2.75416144
22Abnormality of the ileum (HP:0001549)2.75189934
23Abnormal mitochondria in muscle tissue (HP:0008316)2.71442617
24Hypothermia (HP:0002045)2.67026165
25Methylmalonic acidemia (HP:0002912)2.65748029
26Abnormality of chromosome stability (HP:0003220)2.64523419
27Hepatic necrosis (HP:0002605)2.63854069
28Abnormality of the pons (HP:0007361)2.62637188
29Recurrent abscess formation (HP:0002722)2.62225131
30Increased hepatocellular lipid droplets (HP:0006565)2.62214910
31Progressive macrocephaly (HP:0004481)2.62150318
32Acute encephalopathy (HP:0006846)2.61852199
33Type II lissencephaly (HP:0007260)2.61234202
34Abnormality of DNA repair (HP:0003254)2.59594351
35Pendular nystagmus (HP:0012043)2.59137743
36True hermaphroditism (HP:0010459)2.58112879
37Progressive inability to walk (HP:0002505)2.58075791
38Febrile seizures (HP:0002373)2.57025170
39Type I transferrin isoform profile (HP:0003642)2.53949884
40Type 2 muscle fiber atrophy (HP:0003554)2.47520782
41Neoplasm of the tracheobronchial system (HP:0100552)2.47424335
42Microvesicular hepatic steatosis (HP:0001414)2.47195299
43Abnormality of the renal medulla (HP:0100957)2.46643844
44Reduced antithrombin III activity (HP:0001976)2.45978023
45Hypoplasia of the pons (HP:0012110)2.45205850
46Abnormal hair whorl (HP:0010721)2.44904469
47Increased serum lactate (HP:0002151)2.43088884
48Recurrent pneumonia (HP:0006532)2.42221848
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42185526
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42185526
51Sclerocornea (HP:0000647)2.41067368
52Abnormality of alanine metabolism (HP:0010916)2.40535610
53Hyperalaninemia (HP:0003348)2.40535610
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40535610
55Chronic hepatic failure (HP:0100626)2.40099923
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.39018352
57Absent/shortened dynein arms (HP:0200106)2.39018352
58Septo-optic dysplasia (HP:0100842)2.38465401
59Renal Fanconi syndrome (HP:0001994)2.37913250
60Cystic liver disease (HP:0006706)2.35011836
61Methylmalonic aciduria (HP:0012120)2.32258884
62Abnormal glycosylation (HP:0012345)2.32168011
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32168011
64Abnormal protein N-linked glycosylation (HP:0012347)2.32168011
65Abnormal protein glycosylation (HP:0012346)2.32168011
66Abnormality of the prostate (HP:0008775)2.32075841
67Abnormal ciliary motility (HP:0012262)2.31156860
68Congenital primary aphakia (HP:0007707)2.30708727
69Stomach cancer (HP:0012126)2.30283265
70Myositis (HP:0100614)2.29371080
71Gait imbalance (HP:0002141)2.28527491
72Median cleft lip (HP:0000161)2.28056474
73Nephrogenic diabetes insipidus (HP:0009806)2.27964848
74Duodenal stenosis (HP:0100867)2.25498137
75Small intestinal stenosis (HP:0012848)2.25498137
76Male pseudohermaphroditism (HP:0000037)2.22670699
77Large for gestational age (HP:0001520)2.21557163
78Ketoacidosis (HP:0001993)2.21218634
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20270512
803-Methylglutaconic aciduria (HP:0003535)2.19716203
81Colon cancer (HP:0003003)2.19295700
82Retinal dysplasia (HP:0007973)2.19206363
83Abnormal spermatogenesis (HP:0008669)2.19134397
84Inability to walk (HP:0002540)2.18953002
85Orchitis (HP:0100796)2.18800740
86Myelodysplasia (HP:0002863)2.17959396
87Abolished electroretinogram (ERG) (HP:0000550)2.17600592
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17398558
89Attenuation of retinal blood vessels (HP:0007843)2.15583386
90Polydipsia (HP:0001959)2.14730213
91Abnormal drinking behavior (HP:0030082)2.14730213
92Hypoproteinemia (HP:0003075)2.14311970
93Azoospermia (HP:0000027)2.13450766
94Optic disc pallor (HP:0000543)2.12620005
95Abnormality of the carotid arteries (HP:0005344)2.11232514
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.09743643
97Ectopic kidney (HP:0000086)2.09134216
98Medial flaring of the eyebrow (HP:0010747)2.08097592
99Reticulocytopenia (HP:0001896)2.07606617
100Abnormality of the nasal septum (HP:0000419)2.06771069
101Duplication of thumb phalanx (HP:0009942)2.05442128
102Lactic acidosis (HP:0003128)2.04071671
103Genital tract atresia (HP:0001827)2.03369127
104Recurrent bacterial skin infections (HP:0005406)2.01864043
105Obstructive lung disease (HP:0006536)2.00636140
106Chronic obstructive pulmonary disease (HP:0006510)2.00636140
107Birth length less than 3rd percentile (HP:0003561)1.98616053
108Encephalitis (HP:0002383)1.98013000
109Pancreatic fibrosis (HP:0100732)1.97170913
110Hypergonadotropic hypogonadism (HP:0000815)1.97139482
111Furrowed tongue (HP:0000221)1.97100759
112Preaxial hand polydactyly (HP:0001177)1.95969103
113Renal cortical cysts (HP:0000803)1.95128425
114Bone marrow hypocellularity (HP:0005528)1.95119955
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95055552
116Congenital stationary night blindness (HP:0007642)1.95039308
117Vaginal atresia (HP:0000148)1.94389343
118Hypoplasia of the fovea (HP:0007750)1.93967377
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.93967377
120Muscle fiber atrophy (HP:0100295)1.93766699
121Recurrent fungal infections (HP:0002841)1.93318513
122Keratoconjunctivitis sicca (HP:0001097)1.92509321
123Anencephaly (HP:0002323)1.91510363
124CNS demyelination (HP:0007305)1.91097786
125Vasculitis (HP:0002633)1.89836452
126Optic nerve hypoplasia (HP:0000609)1.88607670
127Abnormality of the labia minora (HP:0012880)1.87840056
128Constricted visual fields (HP:0001133)1.87590185
129IgM deficiency (HP:0002850)1.86199406
130Postaxial foot polydactyly (HP:0001830)1.86060032
131Meningitis (HP:0001287)1.85476285
132Stomatitis (HP:0010280)1.84539597
133Recurrent lower respiratory tract infections (HP:0002783)1.84395380
134Lissencephaly (HP:0001339)1.84033818
135Congenital, generalized hypertrichosis (HP:0004540)1.83621166
136Abnormality of the duodenum (HP:0002246)1.82942006
137Keratoconjunctivitis (HP:0001096)1.82813905
138Chorioretinal atrophy (HP:0000533)1.81639379
139Hyperglycinemia (HP:0002154)1.81029235
140Ketosis (HP:0001946)1.80786957
141Adrenal hypoplasia (HP:0000835)1.79297031
142Intestinal atresia (HP:0011100)1.78837282
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78545018
144Mediastinal lymphadenopathy (HP:0100721)1.78491435
145Congenital sensorineural hearing impairment (HP:0008527)1.78458438
146Triphalangeal thumb (HP:0001199)1.77910918
147Facial cleft (HP:0002006)1.77567334
148Recurrent cutaneous fungal infections (HP:0011370)1.77397655
149Chronic mucocutaneous candidiasis (HP:0002728)1.77397655
150Protruding tongue (HP:0010808)1.77105490
151IgG deficiency (HP:0004315)1.76246469
152White forelock (HP:0002211)1.76241106
153Increased intramyocellular lipid droplets (HP:0012240)1.75999075
154Tubulointerstitial nephritis (HP:0001970)1.75553728
155Patchy hypopigmentation of hair (HP:0011365)1.75531351
156Abnormal biliary tract physiology (HP:0012439)1.75336203
157Bile duct proliferation (HP:0001408)1.75336203
158Eczematoid dermatitis (HP:0000976)1.74841606
159Cheilitis (HP:0100825)1.74180950
160Congenital hepatic fibrosis (HP:0002612)1.74112686
161Brushfield spots (HP:0001088)1.74083678
162Nephroblastoma (Wilms tumor) (HP:0002667)1.74002788
163Abnormality of B cell number (HP:0010975)1.73200276
164Thyroid-stimulating hormone excess (HP:0002925)1.72036930
165Lethargy (HP:0001254)1.72031003
166Abnormality of the columella (HP:0009929)1.71436185
167Increased IgM level (HP:0003496)1.71132456
168Pancreatic cysts (HP:0001737)1.71081250
169Gaze-evoked nystagmus (HP:0000640)1.71044965
170Hyperventilation (HP:0002883)1.70434002
171Polyuria (HP:0000103)1.70273192
172Increased corneal curvature (HP:0100692)1.70070705
173Keratoconus (HP:0000563)1.70070705
174Dry hair (HP:0011359)1.70047705
175Abnormality of male internal genitalia (HP:0000022)1.69302798
176Abnormality of the renal cortex (HP:0011035)1.68679761
177Embryonal renal neoplasm (HP:0011794)1.68118236
178Abnormality of vitamin B metabolism (HP:0004340)1.67974309
179Hyperglycinuria (HP:0003108)1.67070739
180Abnormal respiratory motile cilium physiology (HP:0012261)1.66879582
181Decreased central vision (HP:0007663)1.66291525
182Supernumerary spleens (HP:0009799)1.66085317
183Abnormal number of erythroid precursors (HP:0012131)1.64136918
184Rectovaginal fistula (HP:0000143)1.62898479
185Rectal fistula (HP:0100590)1.62898479
186Cerebral hypomyelination (HP:0006808)1.62545664
187Abnormal rod and cone electroretinograms (HP:0008323)1.62170252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.27925386
2CASK3.27697463
3STK163.19136134
4ZAK3.14946152
5MAP3K143.01898099
6TXK2.82845096
7TNIK2.78013481
8VRK22.51541164
9MAP4K22.45076773
10TRIM282.35544847
11TSSK62.19357352
12EIF2AK22.14303571
13YES12.06806775
14MKNK22.03755703
15WNK31.96443522
16PBK1.90238047
17BMPR1B1.87308982
18IRAK41.80795518
19MKNK11.77187105
20IRAK31.74447628
21VRK11.71516851
22OXSR11.69489576
23PIM21.68888976
24PINK11.67453001
25ADRBK21.64348660
26SIK31.63333459
27CCNB11.59223074
28TEC1.55965802
29SRPK11.49369991
30PAK31.48287410
31BCKDK1.47409799
32BMPR21.44144880
33MUSK1.42417091
34CDK81.37437021
35INSRR1.36861776
36NUAK11.36011662
37EIF2AK31.33523808
38CLK11.32773405
39PRPF4B1.31981180
40MAP2K71.31438109
41WNK41.31376862
42NME11.30372335
43STK391.29126461
44DYRK31.27357030
45IKBKB1.26383345
46JAK31.25803816
47CSNK1G31.25695034
48GRK11.24727214
49CSNK1G11.22583169
50CSNK1G21.18774655
51ERBB31.16762389
52SGK21.12351271
53ATR1.12045898
54NLK1.09899865
55MAP3K41.07114676
56NEK61.06337023
57CDK31.04781769
58CHUK1.04378791
59MAP3K121.03091771
60BCR1.03030666
61MAP4K11.02436255
62BRD41.01688068
63PLK41.01062340
64IRAK10.99061629
65BUB10.98467885
66KIT0.98324499
67EPHA30.97312156
68IKBKE0.96974193
69CDK190.96622157
70DYRK20.96360396
71DAPK20.95630781
72TAF10.94816681
73CSNK1A1L0.92642433
74TYK20.91114475
75BTK0.90045800
76TIE10.87525501
77PKN10.86001752
78MAPK130.85833967
79NEK90.84889882
80TAOK30.84403206
81PIM10.83110019
82BLK0.82233043
83TGFBR10.80317391
84WEE10.79092022
85AKT30.78663337
86LYN0.78559793
87RPS6KA50.78214679
88TBK10.76795531
89TAOK20.75570241
90MAPKAPK50.75136400
91MST40.74776142
92ADRBK10.74041848
93ACVR1B0.71649697
94SYK0.70985373
95MAP3K130.70772243
96RPS6KA40.70505799
97PIK3CG0.70263009
98GRK70.64754806
99MAPK150.64649859
100PLK10.64603994
101PHKG10.62725186
102PHKG20.62725186
103AURKB0.62535839
104PASK0.62373555
105PRKCG0.62144987
106CDC70.61298488
107STK40.60217117
108BRSK20.59882961
109CAMKK20.58569161
110FGFR20.57807427
111STK240.57708000
112PIK3CA0.57486738
113PLK30.57012900
114STK30.55467005
115PLK20.54884887
116TNK20.54543834
117PNCK0.53843214
118PDK20.53225974
119NEK10.52851640
120PRKCQ0.52564236
121CDK70.51945179
122MAP2K60.51892751
123FER0.50420759
124RPS6KB10.50048412
125CDK90.49401021
126JAK10.48259115
127CHEK20.47930804
128PRKCE0.47059743
129TLK10.47055672
130EIF2AK10.46519812
131RIPK40.46351894
132OBSCN0.45419483
133CSNK1A10.44833416
134TTK0.44175066
135FLT30.43445861
136MYLK0.42870354
137STK38L0.42209665
138SGK2230.40706773
139SGK4940.40706773
140NME20.40585155
141NEK20.39986213
142PRKCI0.39820016
143MAPK70.39804616
144ATM0.39247053
145IGF1R0.36132937
146CAMK2A0.31222684
147PRKACA0.29644188

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.20407744
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.03148398
3Homologous recombination_Homo sapiens_hsa034403.01778553
4Oxidative phosphorylation_Homo sapiens_hsa001902.75281352
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48596669
6Selenocompound metabolism_Homo sapiens_hsa004502.31019348
7Basal transcription factors_Homo sapiens_hsa030222.21825892
8Non-homologous end-joining_Homo sapiens_hsa034502.18768779
9Parkinsons disease_Homo sapiens_hsa050122.18537066
10RNA polymerase_Homo sapiens_hsa030202.14116870
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.12133528
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.07724865
13Butanoate metabolism_Homo sapiens_hsa006502.04214055
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.04101179
15Mismatch repair_Homo sapiens_hsa034302.02197816
16Graft-versus-host disease_Homo sapiens_hsa053322.00809926
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00186959
18DNA replication_Homo sapiens_hsa030301.98430511
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93563987
20Allograft rejection_Homo sapiens_hsa053301.90274659
21Base excision repair_Homo sapiens_hsa034101.82462918
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81489655
23Autoimmune thyroid disease_Homo sapiens_hsa053201.80127406
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73758763
25Herpes simplex infection_Homo sapiens_hsa051681.73642548
26Hematopoietic cell lineage_Homo sapiens_hsa046401.70438614
27Primary immunodeficiency_Homo sapiens_hsa053401.69272545
28Measles_Homo sapiens_hsa051621.68185055
29Sulfur metabolism_Homo sapiens_hsa009201.65704609
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62571788
31Pyrimidine metabolism_Homo sapiens_hsa002401.62056578
32Nucleotide excision repair_Homo sapiens_hsa034201.58654597
33Propanoate metabolism_Homo sapiens_hsa006401.57831099
34Nitrogen metabolism_Homo sapiens_hsa009101.56301376
35Rheumatoid arthritis_Homo sapiens_hsa053231.53065050
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46678280
37One carbon pool by folate_Homo sapiens_hsa006701.45979147
38Fatty acid elongation_Homo sapiens_hsa000621.44195160
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41880567
40Legionellosis_Homo sapiens_hsa051341.41384078
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41320789
42Tryptophan metabolism_Homo sapiens_hsa003801.39113516
43Sulfur relay system_Homo sapiens_hsa041221.38836420
44Proteasome_Homo sapiens_hsa030501.36366730
45Cell cycle_Homo sapiens_hsa041101.34156412
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33186523
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32229783
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31903986
49Spliceosome_Homo sapiens_hsa030401.29399691
50Alzheimers disease_Homo sapiens_hsa050101.27578178
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27249802
52RNA degradation_Homo sapiens_hsa030181.26985175
53Caffeine metabolism_Homo sapiens_hsa002321.25986533
54Peroxisome_Homo sapiens_hsa041461.24058736
55Protein export_Homo sapiens_hsa030601.22455970
56Influenza A_Homo sapiens_hsa051641.21500149
57Type I diabetes mellitus_Homo sapiens_hsa049401.19269181
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18175948
59Asthma_Homo sapiens_hsa053101.17815747
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15444043
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14373272
62Purine metabolism_Homo sapiens_hsa002301.14148238
63Leishmaniasis_Homo sapiens_hsa051401.14125353
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13776373
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11037885
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.09741802
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09226508
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06793862
69Folate biosynthesis_Homo sapiens_hsa007901.05418631
70Malaria_Homo sapiens_hsa051441.03516212
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99252552
72Arachidonic acid metabolism_Homo sapiens_hsa005900.97956967
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.95385277
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94997030
75Vitamin digestion and absorption_Homo sapiens_hsa049770.94266867
76p53 signaling pathway_Homo sapiens_hsa041150.88659999
77TNF signaling pathway_Homo sapiens_hsa046680.88415133
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88264714
79Ribosome_Homo sapiens_hsa030100.87897899
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82980742
81Epstein-Barr virus infection_Homo sapiens_hsa051690.82404789
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.82336364
83Ether lipid metabolism_Homo sapiens_hsa005650.80987032
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79322608
85African trypanosomiasis_Homo sapiens_hsa051430.77423441
86Other glycan degradation_Homo sapiens_hsa005110.76962595
87Regulation of autophagy_Homo sapiens_hsa041400.74369444
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74235960
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74052326
90Sphingolipid metabolism_Homo sapiens_hsa006000.74033697
91Systemic lupus erythematosus_Homo sapiens_hsa053220.73049748
92Collecting duct acid secretion_Homo sapiens_hsa049660.73012599
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.72626100
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70364201
95Apoptosis_Homo sapiens_hsa042100.69062925
96Hepatitis B_Homo sapiens_hsa051610.68164845
97Chemical carcinogenesis_Homo sapiens_hsa052040.67581625
98Fatty acid metabolism_Homo sapiens_hsa012120.67322976
99Cardiac muscle contraction_Homo sapiens_hsa042600.66727809
100RNA transport_Homo sapiens_hsa030130.65300249
101Phagosome_Homo sapiens_hsa041450.63909265
102Tuberculosis_Homo sapiens_hsa051520.62789676
103Pertussis_Homo sapiens_hsa051330.61709434
104mRNA surveillance pathway_Homo sapiens_hsa030150.61515265
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61217668
106N-Glycan biosynthesis_Homo sapiens_hsa005100.60847319
107Osteoclast differentiation_Homo sapiens_hsa043800.60668219
108Phototransduction_Homo sapiens_hsa047440.60430352
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60398083
110Pyruvate metabolism_Homo sapiens_hsa006200.58041642
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57861322
112Antigen processing and presentation_Homo sapiens_hsa046120.57629410
113Olfactory transduction_Homo sapiens_hsa047400.56570052
114Vitamin B6 metabolism_Homo sapiens_hsa007500.54817300
115Fat digestion and absorption_Homo sapiens_hsa049750.52461905
116Taste transduction_Homo sapiens_hsa047420.49838990
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49679337
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49660494
119Hepatitis C_Homo sapiens_hsa051600.49270999
120Steroid biosynthesis_Homo sapiens_hsa001000.48162715
121Chemokine signaling pathway_Homo sapiens_hsa040620.47902632
122Staphylococcus aureus infection_Homo sapiens_hsa051500.47226254
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46229845
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42901681
125Linoleic acid metabolism_Homo sapiens_hsa005910.42798599
126Fatty acid degradation_Homo sapiens_hsa000710.42015322
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.41995737
128ABC transporters_Homo sapiens_hsa020100.40700807
129Viral carcinogenesis_Homo sapiens_hsa052030.40349111
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.40167727
131beta-Alanine metabolism_Homo sapiens_hsa004100.39852077
132Nicotine addiction_Homo sapiens_hsa050330.38912941
133Retinol metabolism_Homo sapiens_hsa008300.38041957
134Glutathione metabolism_Homo sapiens_hsa004800.37589446
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34382411
136HTLV-I infection_Homo sapiens_hsa051660.33337633
137Arginine and proline metabolism_Homo sapiens_hsa003300.32758862
138Oocyte meiosis_Homo sapiens_hsa041140.31952311
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31802628
140B cell receptor signaling pathway_Homo sapiens_hsa046620.30896057
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30226604
142Toxoplasmosis_Homo sapiens_hsa051450.28107002
143Serotonergic synapse_Homo sapiens_hsa047260.27547298
144Huntingtons disease_Homo sapiens_hsa050160.26723714
145Circadian rhythm_Homo sapiens_hsa047100.26436629
146Salmonella infection_Homo sapiens_hsa051320.24931644
147Metabolic pathways_Homo sapiens_hsa011000.24374575

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