FDXR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to follicle-stimulating hormone stimulus (GO:0071372)9.33668749
2progesterone metabolic process (GO:0042448)7.93204569
3ketone biosynthetic process (GO:0042181)7.79136373
4hormone biosynthetic process (GO:0042446)7.22648287
5androgen metabolic process (GO:0008209)6.70600801
6response to follicle-stimulating hormone (GO:0032354)6.70394077
7cellular response to zinc ion (GO:0071294)6.66435374
8estrogen metabolic process (GO:0008210)5.87908392
9alpha-linolenic acid metabolic process (GO:0036109)5.26383196
10cellular response to interferon-alpha (GO:0035457)5.22473608
11response to lead ion (GO:0010288)5.08120870
12cellular response to antibiotic (GO:0071236)4.99946206
13benzene-containing compound metabolic process (GO:0042537)4.89803604
14Golgi transport vesicle coating (GO:0048200)4.87793646
15COPI coating of Golgi vesicle (GO:0048205)4.87793646
16cellular response to growth hormone stimulus (GO:0071378)4.84173415
17bile acid biosynthetic process (GO:0006699)4.83933540
18proline biosynthetic process (GO:0006561)4.78948818
19adhesion of symbiont to host (GO:0044406)4.73401575
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.72341821
21high-density lipoprotein particle remodeling (GO:0034375)4.71769485
22positive regulation of triglyceride biosynthetic process (GO:0010867)4.55721426
23cellular response to gonadotropin stimulus (GO:0071371)4.48339509
24low-density lipoprotein particle clearance (GO:0034383)4.41433438
25cellular ketone metabolic process (GO:0042180)4.37561981
26toxin metabolic process (GO:0009404)4.34581163
27reverse cholesterol transport (GO:0043691)4.28388684
28cholesterol catabolic process (GO:0006707)4.17314124
29sterol catabolic process (GO:0016127)4.17314124
30response to leptin (GO:0044321)4.09449990
31* steroid biosynthetic process (GO:0006694)3.97038970
32mitochondrial DNA metabolic process (GO:0032042)3.92345548
33phagocytosis, recognition (GO:0006910)3.88247145
34positive regulation of hormone biosynthetic process (GO:0046886)3.85153188
35positive regulation of triglyceride metabolic process (GO:0090208)3.81448136
36positive regulation of male gonad development (GO:2000020)3.74709683
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.72799513
38cellular response to dexamethasone stimulus (GO:0071549)3.72626613
39response to dexamethasone (GO:0071548)3.71636083
40cellular hormone metabolic process (GO:0034754)3.66751478
41glyoxylate metabolic process (GO:0046487)3.66027973
42regulation of translational fidelity (GO:0006450)3.64906800
43regulation of male gonad development (GO:2000018)3.62270625
44cytokine metabolic process (GO:0042107)3.60243330
45gonadal mesoderm development (GO:0007506)3.58127041
46L-phenylalanine catabolic process (GO:0006559)3.58046026
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58046026
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.56953786
49cellular response to toxic substance (GO:0097237)3.56442531
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55135337
51L-phenylalanine metabolic process (GO:0006558)3.55135337
52ribosomal small subunit biogenesis (GO:0042274)3.54733039
53protein-lipid complex remodeling (GO:0034368)3.53306204
54macromolecular complex remodeling (GO:0034367)3.53306204
55plasma lipoprotein particle remodeling (GO:0034369)3.53306204
56proline metabolic process (GO:0006560)3.50179757
57bile acid metabolic process (GO:0008206)3.48811619
58cellular response to epinephrine stimulus (GO:0071872)3.44991074
59plasma lipoprotein particle clearance (GO:0034381)3.43937828
60response to growth hormone (GO:0060416)3.43081018
61peptidyl-arginine omega-N-methylation (GO:0035247)3.37966511
62regulation of cholesterol biosynthetic process (GO:0045540)3.37850083
63amyloid precursor protein catabolic process (GO:0042987)3.35731366
64cholesterol efflux (GO:0033344)3.34173146
65linoleic acid metabolic process (GO:0043651)3.32373144
66ethanol oxidation (GO:0006069)3.30400908
67regulation of cholesterol metabolic process (GO:0090181)3.28831718
68intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.23746935
69regulation of triglyceride biosynthetic process (GO:0010866)3.22287195
70regulation of cholesterol storage (GO:0010885)3.20043796
71histone arginine methylation (GO:0034969)3.16200812
72sterol transport (GO:0015918)3.16192341
73cholesterol transport (GO:0030301)3.16192341
74mitotic chromosome condensation (GO:0007076)3.12966430
75response to phenylpropanoid (GO:0080184)3.12223324
76response to insecticide (GO:0017085)3.10492811
77* sterol metabolic process (GO:0016125)3.09426975
78renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.09102437
79plasma lipoprotein particle organization (GO:0071827)3.07859327
80acylglycerol homeostasis (GO:0055090)3.06792252
81triglyceride homeostasis (GO:0070328)3.06792252
82valine metabolic process (GO:0006573)3.06099436
83positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.05460698
84renal system process involved in regulation of blood volume (GO:0001977)3.04329189
85formation of translation preinitiation complex (GO:0001731)3.02574042
86protein retention in ER lumen (GO:0006621)3.01282739
87positive regulation of systemic arterial blood pressure (GO:0003084)3.00688579
88positive regulation of hormone metabolic process (GO:0032352)2.97148393
89primary alcohol catabolic process (GO:0034310)2.96713968
90response to cadmium ion (GO:0046686)2.94233124
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.93811456
92Leydig cell differentiation (GO:0033327)2.93794747
93response to methylmercury (GO:0051597)2.93499697
94mitochondrial fusion (GO:0008053)2.93018196
95maturation of SSU-rRNA (GO:0030490)2.92724047
96sulfur amino acid catabolic process (GO:0000098)2.92551624
97protein-lipid complex subunit organization (GO:0071825)2.92071545
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90672449
99response to gonadotropin (GO:0034698)2.90545810
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90229781
101protoporphyrinogen IX biosynthetic process (GO:0006782)2.89440043
102protoporphyrinogen IX metabolic process (GO:0046501)2.88045211
103regulation of triglyceride metabolic process (GO:0090207)2.87538393
104aromatic amino acid family catabolic process (GO:0009074)2.87033645
105nucleobase-containing small molecule interconversion (GO:0015949)2.86944270
106intracellular lipid transport (GO:0032365)2.86664111
107protein maturation by protein folding (GO:0022417)2.85940311
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.84879147
109dicarboxylic acid metabolic process (GO:0043648)2.84433368
110response to epinephrine (GO:0071871)2.83678944
111DNA unwinding involved in DNA replication (GO:0006268)2.81602325
112apoptotic process involved in morphogenesis (GO:0060561)2.81396720
113pentose-phosphate shunt (GO:0006098)2.79404512
114vitamin D metabolic process (GO:0042359)2.78650504
115mitotic G1 DNA damage checkpoint (GO:0031571)2.78253402
116amino-acid betaine metabolic process (GO:0006577)2.78002235
117activation of Rac GTPase activity (GO:0032863)2.75634998
118response to interferon-alpha (GO:0035455)2.73426627
119regulation of cholesterol homeostasis (GO:2000188)2.73108575
120NADPH regeneration (GO:0006740)2.70381943
121L-serine metabolic process (GO:0006563)2.69862322
122protein insertion into membrane (GO:0051205)2.69596668
123serine family amino acid biosynthetic process (GO:0009070)2.69195603
124peptidyl-arginine N-methylation (GO:0035246)2.68434546
125peptidyl-arginine methylation (GO:0018216)2.68434546
126endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.68428434
127glycine metabolic process (GO:0006544)2.68324181
128lysine catabolic process (GO:0006554)2.67707669
129lysine metabolic process (GO:0006553)2.67707669
130very-low-density lipoprotein particle assembly (GO:0034379)2.67293705
131plasma lipoprotein particle assembly (GO:0034377)2.66659960
132ethanol metabolic process (GO:0006067)2.66258956
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61060252
134mating behavior (GO:0007617)2.59335688
135mitotic G1/S transition checkpoint (GO:0044819)2.58291788
136ribosomal small subunit assembly (GO:0000028)2.57541705
137nuclear envelope reassembly (GO:0031468)2.55820724
138mitotic nuclear envelope reassembly (GO:0007084)2.55820724
139establishment of apical/basal cell polarity (GO:0035089)2.55800077
140pinocytosis (GO:0006907)2.53172777
141regulation of mitochondrial translation (GO:0070129)2.52449752
142protein localization to endosome (GO:0036010)2.50708141
143glucose catabolic process (GO:0006007)2.50443289
144DNA strand elongation involved in DNA replication (GO:0006271)2.49198736
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48730309
146rRNA transcription (GO:0009303)2.47824411
147DNA strand elongation (GO:0022616)2.47367265
148UV protection (GO:0009650)2.47279536
149positive regulation of steroid biosynthetic process (GO:0010893)2.44657743
150pentose metabolic process (GO:0019321)2.44495829
151viral transcription (GO:0019083)2.44426177
152mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.39576079
153positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.38448547
154hyaluronan catabolic process (GO:0030214)2.35357192
155GDP-mannose metabolic process (GO:0019673)2.35309534
156positive regulation of nuclease activity (GO:0032075)2.34783407
157ribonucleoprotein complex biogenesis (GO:0022613)2.34646020
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34257700
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34137502
160activation of MAPKKK activity (GO:0000185)2.32982904
1614-hydroxyproline metabolic process (GO:0019471)2.32259723
162regulation of steroid biosynthetic process (GO:0050810)2.31541581
163adherens junction assembly (GO:0034333)2.31341503
164C21-steroid hormone biosynthetic process (GO:0006700)15.4774276
165estrogen biosynthetic process (GO:0006703)12.8755635
166glucocorticoid biosynthetic process (GO:0006704)12.8256725
167androgen biosynthetic process (GO:0006702)12.3458622
168glucocorticoid metabolic process (GO:0008211)10.6086126
169C21-steroid hormone metabolic process (GO:0008207)10.3522019
170cellular response to cadmium ion (GO:0071276)10.0699130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.47115524
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.42341824
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.06433097
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.73913797
5* TP63_17297297_ChIP-ChIP_HaCaT_Human3.66210563
6E2F7_22180533_ChIP-Seq_HELA_Human3.24955598
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22482271
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.06897415
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.88181738
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.65872255
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59763581
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.39811376
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36523164
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23705995
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17286834
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.09974914
17CLOCK_20551151_ChIP-Seq_293T_Human2.07714805
18MYC_22102868_ChIP-Seq_BL_Human2.05408498
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01090591
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98453846
21VDR_21846776_ChIP-Seq_THP-1_Human1.96562401
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93509239
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.92420130
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78618233
25LXR_22292898_ChIP-Seq_THP-1_Human1.74691150
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72663161
27GATA1_22025678_ChIP-Seq_K562_Human1.71915840
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67391528
29* TP53_22127205_ChIP-Seq_IMR90_Human1.63451205
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62946204
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56038396
32* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54212442
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54083167
34XRN2_22483619_ChIP-Seq_HELA_Human1.52130764
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50891681
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50719298
37* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49705784
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49355312
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47906876
40* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46946140
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46697628
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44907535
43CIITA_25753668_ChIP-Seq_RAJI_Human1.44350408
44* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40992677
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40032439
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38321572
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36387806
48* ATF3_27146783_Chip-Seq_COLON_Human1.33120620
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32553731
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32167868
51* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31522914
52CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30997069
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30957541
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30793581
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30199442
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.30037671
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29906535
58NCOR1_26117541_ChIP-Seq_K562_Human1.28680719
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27469067
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27218331
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27144177
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26769025
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24977095
64MAF_26560356_Chip-Seq_TH1_Human1.24204286
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23506013
66* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23444463
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22342714
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21093958
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21072264
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19032347
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18699265
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18698799
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18552313
74UTX_26944678_Chip-Seq_JUKART_Human1.17758067
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16582978
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15714938
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15521759
78DCP1A_22483619_ChIP-Seq_HELA_Human1.15411566
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15320480
80SCL_19346495_ChIP-Seq_HPC-7_Human1.14827712
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13964123
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13575829
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13098105
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11440475
85ZNF263_19887448_ChIP-Seq_K562_Human1.11285388
86* ETS1_20019798_ChIP-Seq_JURKAT_Human1.11067998
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10943086
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10776708
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10485979
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10420284
91SMC4_20622854_ChIP-Seq_HELA_Human1.09834420
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09415875
93* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09349822
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08686887
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08004100
96P68_20966046_ChIP-Seq_HELA_Human1.07382304
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06986021
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06693776
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06016934
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.05997124
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05837692
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05792743
103FOXP3_21729870_ChIP-Seq_TREG_Human1.04322844
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04290661
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04276351
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.04202317
107KDM2B_26808549_Chip-Seq_DND41_Human1.03464506
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.02954636
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02701169
110* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02636553
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02474684
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01447583
113GABP_19822575_ChIP-Seq_HepG2_Human1.01339520
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01191324
115TCF7_22412390_ChIP-Seq_EML_Mouse1.01160449
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.01125941
117KDM2B_26808549_Chip-Seq_K562_Human1.00865020
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00460463
119BCOR_27268052_Chip-Seq_Bcells_Human1.00222843
120TTF2_22483619_ChIP-Seq_HELA_Human1.00057830
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99970966
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99907565
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99850810
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99775099
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.98869494
126* BCL6_27268052_Chip-Seq_Bcells_Human0.98744781
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.98515245
128* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98479177
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98327738
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98288775
131MAF_26560356_Chip-Seq_TH2_Human0.98065161
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97321274
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96990823
134VDR_24763502_ChIP-Seq_THP-1_Human0.96787216
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96031771
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95511615
137IRF8_22096565_ChIP-ChIP_GC-B_Human0.95225139
138* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95186336
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94382074
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94048538
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93853159
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.93066952
143RACK7_27058665_Chip-Seq_MCF-7_Human0.92330281
144PHF8_20622854_ChIP-Seq_HELA_Human0.92177884
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.90452987
146* KDM5A_27292631_Chip-Seq_BREAST_Human0.89920553
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88798137
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88245798
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87613461
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87381817
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86597924
152CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86515729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000639_abnormal_adrenal_gland5.46637556
2MP0005360_urolithiasis5.02850574
3MP0002909_abnormal_adrenal_gland4.69388287
4MP0002139_abnormal_hepatobiliary_system4.47817807
5MP0008875_abnormal_xenobiotic_pharmacok4.44139911
6MP0003941_abnormal_skin_development4.40080306
7MP0005365_abnormal_bile_salt3.74829670
8MP0005085_abnormal_gallbladder_physiolo3.15111808
9MP0003191_abnormal_cellular_cholesterol3.13030624
10MP0010329_abnormal_lipoprotein_level3.04211631
11MP0003806_abnormal_nucleotide_metabolis2.92947472
12MP0009840_abnormal_foam_cell2.83305153
13MP0005451_abnormal_body_composition2.79883447
14MP0005058_abnormal_lysosome_morphology2.68017719
15MP0005319_abnormal_enzyme/_coenzyme2.66370490
16MP0003186_abnormal_redox_activity2.55135718
17MP0005647_abnormal_sex_gland2.54045796
18MP0005636_abnormal_mineral_homeostasis2.42202962
19MP0001765_abnormal_ion_homeostasis2.34761156
20MP0005584_abnormal_enzyme/coenzyme_acti2.32134939
21MP0003111_abnormal_nucleus_morphology2.27449420
22MP0002877_abnormal_melanocyte_morpholog2.07081788
23MP0000609_abnormal_liver_physiology2.00994598
24MP0003252_abnormal_bile_duct2.00414897
25MP0005501_abnormal_skin_physiology1.99652047
26MP0010030_abnormal_orbit_morphology1.98993794
27MP0004233_abnormal_muscle_weight1.97443696
28MP0003693_abnormal_embryo_hatching1.92906182
29MP0005257_abnormal_intraocular_pressure1.89016606
30MP0008438_abnormal_cutaneous_collagen1.86687870
31MP0001849_ear_inflammation1.84968145
32MP0003638_abnormal_response/metabolism_1.83620537
33MP0002118_abnormal_lipid_homeostasis1.81205740
34MP0000678_abnormal_parathyroid_gland1.78942147
35MP0003315_abnormal_perineum_morphology1.76719978
36MP0002822_catalepsy1.75985044
37MP0001661_extended_life_span1.75907064
38MP0003656_abnormal_erythrocyte_physiolo1.75216276
39MP0008260_abnormal_autophagy1.74975756
40MP0003786_premature_aging1.73936099
41MP0003566_abnormal_cell_adhesion1.73172595
42MP0005332_abnormal_amino_acid1.73095020
43MP0004272_abnormal_basement_membrane1.71344400
44MP0004185_abnormal_adipocyte_glucose1.70291472
45MP0009643_abnormal_urine_homeostasis1.69991777
46MP0003195_calcinosis1.69537891
47MP0010234_abnormal_vibrissa_follicle1.68086010
48MP0008007_abnormal_cellular_replicative1.66939372
49MP0004957_abnormal_blastocyst_morpholog1.64668030
50MP0001853_heart_inflammation1.63210698
51MP0000230_abnormal_systemic_arterial1.58299811
52MP0002089_abnormal_postnatal_growth/wei1.58078163
53MP0000858_altered_metastatic_potential1.57800097
54MP0000685_abnormal_immune_system1.56624958
55MP0009379_abnormal_foot_pigmentation1.56603588
56MP0005076_abnormal_cell_differentiation1.54468998
57MP0005623_abnormal_meninges_morphology1.48072957
58MP0008932_abnormal_embryonic_tissue1.47373963
59MP0003077_abnormal_cell_cycle1.46325491
60MP0006035_abnormal_mitochondrial_morpho1.45128150
61MP0004858_abnormal_nervous_system1.43277384
62MP0001730_embryonic_growth_arrest1.40630966
63MP0008469_abnormal_protein_level1.40449172
64MP0003300_gastrointestinal_ulcer1.39819931
65MP0010094_abnormal_chromosome_stability1.39109810
66MP0003453_abnormal_keratinocyte_physiol1.38868640
67MP0005083_abnormal_biliary_tract1.34015933
68MP0000598_abnormal_liver_morphology1.23752375
69MP0002796_impaired_skin_barrier1.22435978
70MP0001666_abnormal_nutrient_absorption1.21471720
71MP0003953_abnormal_hormone_level1.19902752
72MP0002092_abnormal_eye_morphology1.19892142
73MP0002396_abnormal_hematopoietic_system1.19177608
74MP0006036_abnormal_mitochondrial_physio1.19042122
75MP0010307_abnormal_tumor_latency1.18171760
76MP0003123_paternal_imprinting1.17900308
77MP0003942_abnormal_urinary_system1.15759610
78MP0002697_abnormal_eye_size1.13464621
79MP0001756_abnormal_urination1.13114348
80MP0004147_increased_porphyrin_level1.12833256
81MP0000350_abnormal_cell_proliferation1.12618359
82MP0001915_intracranial_hemorrhage1.11558329
83MP0000537_abnormal_urethra_morphology1.11314112
84MP0002080_prenatal_lethality1.11022070
85MP0009642_abnormal_blood_homeostasis1.10385041
86MP0005670_abnormal_white_adipose1.10182676
87MP0001348_abnormal_lacrimal_gland1.07767995
88MP0000703_abnormal_thymus_morphology1.06442995
89MP0002249_abnormal_larynx_morphology1.05678077
90MP0005464_abnormal_platelet_physiology1.03476461
91MP0003385_abnormal_body_wall1.01437907
92MP0001764_abnormal_homeostasis0.98997540
93MP0004019_abnormal_vitamin_homeostasis0.97836304
94MP0001835_abnormal_antigen_presentation0.97515716
95MP0003763_abnormal_thymus_physiology0.97436360
96MP0009672_abnormal_birth_weight0.97330051
97MP0000313_abnormal_cell_death0.96790685
98MP0002722_abnormal_immune_system0.96229728
99MP0000604_amyloidosis0.95931170
100MP0003329_amyloid_beta_deposits0.95370433
101MP0005380_embryogenesis_phenotype0.94848758
102MP0001672_abnormal_embryogenesis/_devel0.94848758
103MP0000003_abnormal_adipose_tissue0.93842633
104MP0009763_increased_sensitivity_to0.93237795
105MP0002060_abnormal_skin_morphology0.92709959
106MP0001727_abnormal_embryo_implantation0.91514412
107MP0008995_early_reproductive_senescence0.91108841
108MP0003705_abnormal_hypodermis_morpholog0.89837261
109MP0003984_embryonic_growth_retardation0.86743578
110MP0002254_reproductive_system_inflammat0.86710006
111MP0000733_abnormal_muscle_development0.86463421
112MP0004883_abnormal_blood_vessel0.86157937
113MP0005384_cellular_phenotype0.85666657
114MP0000689_abnormal_spleen_morphology0.85276845
115MP0002160_abnormal_reproductive_system0.83393870
116MP0001697_abnormal_embryo_size0.82535845
117MP0002078_abnormal_glucose_homeostasis0.81724232
118MP0000358_abnormal_cell_content/0.79074632
119MP0005508_abnormal_skeleton_morphology0.78802252
120MP0002088_abnormal_embryonic_growth/wei0.78664101
121MP0002086_abnormal_extraembryonic_tissu0.77383517
122MP0005621_abnormal_cell_physiology0.77264968
123MP0002085_abnormal_embryonic_tissue0.77207559
124MP0000490_abnormal_crypts_of0.76946161
125MP0000566_synostosis0.76876517
126MP0003724_increased_susceptibility_to0.76375467
127MP0001119_abnormal_female_reproductive0.75980355
128MP0002166_altered_tumor_susceptibility0.75060536
129MP0005671_abnormal_response_to0.74427674
130MP0005389_reproductive_system_phenotype0.73639851
131MP0000750_abnormal_muscle_regeneration0.73218276
132MP0005193_abnormal_anterior_eye0.72356954
133MP0000747_muscle_weakness0.72093007
134MP0008872_abnormal_physiological_respon0.71861867
135MP0001800_abnormal_humoral_immune0.71338216
136MP0002111_abnormal_tail_morphology0.70173965
137MP0009785_altered_susceptibility_to0.69196057
138MP0009384_cardiac_valve_regurgitation0.69117208
139MP0002269_muscular_atrophy0.68778218
140MP0008004_abnormal_stomach_pH0.68484286
141MP0002084_abnormal_developmental_patter0.67949895
142MP0004084_abnormal_cardiac_muscle0.67944279
143MP0002019_abnormal_tumor_incidence0.67665030
144MP0000653_abnormal_sex_gland0.67571644
145MP0010352_gastrointestinal_tract_polyps0.67157534
146MP0002429_abnormal_blood_cell0.66126209
147MP0002398_abnormal_bone_marrow0.66055982
148MP0002136_abnormal_kidney_physiology0.65679451
149MP0001145_abnormal_male_reproductive0.65551408
150MP0005330_cardiomyopathy0.65506212
151MP0005666_abnormal_adipose_tissue0.63975365
152MP0004197_abnormal_fetal_growth/weight/0.62795920
153MP0010771_integument_phenotype0.62627228
154MP0000631_abnormal_neuroendocrine_gland0.62404494
155MP0002420_abnormal_adaptive_immunity0.62133701
156MP0000013_abnormal_adipose_tissue0.61251727
157MP0003283_abnormal_digestive_organ0.60598775
158MP0005023_abnormal_wound_healing0.60135154
159MP0002210_abnormal_sex_determination0.60032242
160MP0001873_stomach_inflammation0.59980790
161MP0010368_abnormal_lymphatic_system0.59710302
162MP0002970_abnormal_white_adipose0.59476154
163MP0001819_abnormal_immune_cell0.59414128
164MP0000343_altered_response_to0.58324784
165MP0005334_abnormal_fat_pad0.58305605
166MP0005025_abnormal_response_to0.58043135
167MP0001545_abnormal_hematopoietic_system0.57757688
168MP0005397_hematopoietic_system_phenotyp0.57757688
169MP0000716_abnormal_immune_system0.57347207
170MP0005535_abnormal_body_temperature0.56017004
171MP0003436_decreased_susceptibility_to0.55569240
172MP0003866_abnormal_defecation0.54818623
173MP0005387_immune_system_phenotype0.54747207
174MP0001790_abnormal_immune_system0.54747207
175MP0003699_abnormal_female_reproductive0.54621630
176MP0005075_abnormal_melanosome_morpholog0.54423326
177MP0009333_abnormal_splenocyte_physiolog0.54365110
178MP0002419_abnormal_innate_immunity0.54235255
179MP0001929_abnormal_gametogenesis0.53646517
180MP0002723_abnormal_immune_serum0.53631863

Predicted human phenotypes

RankGene SetZ-score
1Renal salt wasting (HP:0000127)8.69986489
2Enlarged penis (HP:0000040)6.81465773
3Decreased circulating renin level (HP:0003351)6.00427179
4Neonatal onset (HP:0003623)5.93334319
5Hypoplasia of the uterus (HP:0000013)5.42733717
6Abnormality of renin-angiotensin system (HP:0000847)5.24488609
7Hyperaldosteronism (HP:0000859)5.21431608
8Increased circulating renin level (HP:0000848)5.12913425
9Sex reversal (HP:0012245)4.96461684
10Abnormal sex determination (HP:0012244)4.96461684
11Orthostatic hypotension (HP:0001278)4.94960939
12Entropion (HP:0000621)4.40429911
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37758391
14Aplasia/hypoplasia of the uterus (HP:0008684)4.18327895
15Gonadal dysgenesis (HP:0000133)4.00446478
16Deep venous thrombosis (HP:0002625)3.75897022
17Azoospermia (HP:0000027)3.69670690
18Hyperammonemia (HP:0001987)3.65314939
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62981724
20Intrahepatic cholestasis (HP:0001406)3.44697851
21Poikiloderma (HP:0001029)3.43728436
22Episodic fever (HP:0001954)3.41853683
23Xanthomatosis (HP:0000991)3.39149955
24Squamous cell carcinoma (HP:0002860)3.33164136
25Testicular neoplasm (HP:0010788)3.27480445
26Ulnar bowing (HP:0003031)3.26122361
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16239542
28Hypobetalipoproteinemia (HP:0003563)3.13210768
29Clitoromegaly (HP:0000057)3.08676189
30Gonadotropin excess (HP:0000837)3.01823195
31Hyperlipoproteinemia (HP:0010980)2.99705787
32Ketosis (HP:0001946)2.98609619
33Abnormal spermatogenesis (HP:0008669)2.96369604
34Protrusio acetabuli (HP:0003179)2.96151211
35Hyperglycinuria (HP:0003108)2.95933170
36Premature ovarian failure (HP:0008209)2.95657032
37Abnormality of fatty-acid metabolism (HP:0004359)2.93586477
38Prolonged partial thromboplastin time (HP:0003645)2.90740025
39Abnormality of carpal bone ossification (HP:0006257)2.89083494
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87144763
41Abnormality of glycine metabolism (HP:0010895)2.87120317
42Abnormality of serine family amino acid metabolism (HP:0010894)2.87120317
43Hypoglycemic coma (HP:0001325)2.86332689
44Adrenal overactivity (HP:0002717)2.79536122
45Accelerated skeletal maturation (HP:0005616)2.78986861
46Premature rupture of membranes (HP:0001788)2.77676248
47Hyperacusis (HP:0010780)2.77090433
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60657504
49Dicarboxylic aciduria (HP:0003215)2.60657504
50Male infertility (HP:0003251)2.57166903
51Breast hypoplasia (HP:0003187)2.56570725
52Delayed CNS myelination (HP:0002188)2.55783770
53Abnormal ossification of hand bones (HP:0005921)2.55039821
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.53908005
55Atelectasis (HP:0100750)2.53256986
56Hyperpituitarism (HP:0010514)2.52466828
57Abnormality of pyrimidine metabolism (HP:0004353)2.50813966
58Hyperkalemia (HP:0002153)2.49724632
59Short nail (HP:0001799)2.49109979
60Complement deficiency (HP:0004431)2.48207739
61Insomnia (HP:0100785)2.47512278
62Vertebral compression fractures (HP:0002953)2.47387740
63Primary adrenal insufficiency (HP:0008207)2.46557998
64Hyperglycinemia (HP:0002154)2.40447032
65Hepatic necrosis (HP:0002605)2.40421652
66Secondary amenorrhea (HP:0000869)2.36513405
67Flat acetabular roof (HP:0003180)2.36426145
68Male pseudohermaphroditism (HP:0000037)2.35564477
69Neonatal hypoglycemia (HP:0001998)2.33723382
70Abnormality of the thoracic spine (HP:0100711)2.32283381
71Abnormal gallbladder physiology (HP:0012438)2.32283240
72Cholecystitis (HP:0001082)2.32283240
73Cutaneous melanoma (HP:0012056)2.32129287
74Hyponatremia (HP:0002902)2.30833186
75Progressive external ophthalmoplegia (HP:0000590)2.30328436
76Diaphragmatic weakness (HP:0009113)2.25410380
77Small epiphyses (HP:0010585)2.24003913
78Flattened epiphyses (HP:0003071)2.23860852
79Truncus arteriosus (HP:0001660)2.22651362
80Hypolipoproteinemia (HP:0010981)2.22291300
8111 pairs of ribs (HP:0000878)2.22053663
82Broad distal phalanx of finger (HP:0009836)2.19961390
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19832641
84Achilles tendon contracture (HP:0001771)2.19370215
85Abnormality of the common coagulation pathway (HP:0010990)2.18099485
86Pulmonary fibrosis (HP:0002206)2.17135189
87Abnormality of methionine metabolism (HP:0010901)2.16907837
88Thoracic kyphosis (HP:0002942)2.14838512
89Hyperbilirubinemia (HP:0002904)2.14750151
90Selective tooth agenesis (HP:0001592)2.14518503
91Upper limb amyotrophy (HP:0009129)2.14278987
92Distal upper limb amyotrophy (HP:0007149)2.14278987
93Reticulocytosis (HP:0001923)2.13510338
94Abnormality of potassium homeostasis (HP:0011042)2.11462240
95Abnormal autonomic nervous system physiology (HP:0012332)2.11171868
96Joint hemorrhage (HP:0005261)2.11041370
97Ketoacidosis (HP:0001993)2.10921799
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.10028950
99Hand muscle atrophy (HP:0009130)2.09566976
100Bifid scrotum (HP:0000048)2.09425475
101Stridor (HP:0010307)2.08864699
102Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08114042
103Metabolic acidosis (HP:0001942)2.06646618
104Abnormal tarsal ossification (HP:0008369)2.04625333
105Hepatocellular necrosis (HP:0001404)2.04099269
106Abnormality of the intrinsic pathway (HP:0010989)2.03910731
107Epidermoid cyst (HP:0200040)2.03605143
108Rough bone trabeculation (HP:0100670)2.01022287
109Abnormality of reticulocytes (HP:0004312)2.00409662
110Premature skin wrinkling (HP:0100678)1.99675673
111Trismus (HP:0000211)1.98748885
112Vomiting (HP:0002013)1.98600359
113Biconcave vertebral bodies (HP:0004586)1.98331532
114Abnormality of the Achilles tendon (HP:0005109)1.97484320
115Seborrheic dermatitis (HP:0001051)1.96918390
116Long palpebral fissure (HP:0000637)1.96566495
117Chronic otitis media (HP:0000389)1.96286834
118Hydroxyprolinuria (HP:0003080)1.95212875
119Abnormality of proline metabolism (HP:0010907)1.95212875
120Abnormality of the distal phalanges of the toes (HP:0010182)1.93396270
121Cervical subluxation (HP:0003308)1.93265331
122Abnormal hand bone ossification (HP:0010660)1.92650658
123Increased muscle lipid content (HP:0009058)1.92089730
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91464399
125Hypertensive crisis (HP:0100735)1.91347724
126Progressive muscle weakness (HP:0003323)1.88045769
127Cupped ribs (HP:0000887)1.87450326
128Natal tooth (HP:0000695)1.87353833
129Abnormality of complement system (HP:0005339)1.85952550
130Hypoalphalipoproteinemia (HP:0003233)1.85250471
131Abnormality of serum amino acid levels (HP:0003112)1.85211413
132Spinal cord compression (HP:0002176)1.85048281
133Abnormality of the umbilical cord (HP:0010881)1.84187957
134Multifactorial inheritance (HP:0001426)1.83780318
135Nausea (HP:0002018)1.82888443
136Abnormality of the tricuspid valve (HP:0001702)1.82020236
137Overlapping toe (HP:0001845)1.81346715
138Spastic diplegia (HP:0001264)1.81147604
139Epiphyseal stippling (HP:0010655)1.81069493
140Abnormality of transition element cation homeostasis (HP:0011030)1.80421644
141Self-mutilation (HP:0000742)1.79846419
142Fat malabsorption (HP:0002630)1.79444873
143Microvesicular hepatic steatosis (HP:0001414)1.76987578
144Bowed forearm bones (HP:0003956)1.76906098
145Bowing of the arm (HP:0006488)1.76906098
146Anomalous pulmonary venous return (HP:0010772)1.76371268
147Advanced eruption of teeth (HP:0006288)1.75963742
148Increased connective tissue (HP:0009025)1.75170235
149Breech presentation (HP:0001623)1.74929966
150Abnormality of sodium homeostasis (HP:0010931)1.74039770
151Absent epiphyses (HP:0010577)1.73940572
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73940572
153Lethargy (HP:0001254)1.73677976
154Hypercholesterolemia (HP:0003124)1.72988145
155Reticulocytopenia (HP:0001896)1.72752678
156Elevated erythrocyte sedimentation rate (HP:0003565)1.71852525
157Precocious puberty (HP:0000826)1.71715362
158Broad alveolar ridges (HP:0000187)1.71580187
159Abnormality of the clitoris (HP:0000056)1.71256322
160Hypertriglyceridemia (HP:0002155)1.69483184
161Nasal polyposis (HP:0100582)1.66927621
162Elbow flexion contracture (HP:0002987)1.66642502
163Ureteral duplication (HP:0000073)1.66431625
164Disproportionate tall stature (HP:0001519)1.66416171
165Asymmetry of the thorax (HP:0001555)1.66336778
166Fragile skin (HP:0001030)1.65309139
167Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64667801
168Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64667801
169Pseudobulbar signs (HP:0002200)1.64503522
170Ragged-red muscle fibers (HP:0003200)1.64262267
171Deviation of the thumb (HP:0009603)1.63877602
172Vertebral arch anomaly (HP:0008438)1.62285945
173Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.62131545
174Abnormality of the nasal mucosa (HP:0000433)1.61469689
175Spinal rigidity (HP:0003306)1.60499151
176Hyperthyroidism (HP:0000836)1.58811452
177Short clavicles (HP:0000894)1.57927230
178Vertebral hypoplasia (HP:0008417)1.57588591
179Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.57588591
180Abnormal trabecular bone morphology (HP:0100671)1.57230524
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.56527319
182Proximal placement of thumb (HP:0009623)1.56082984
183Abnormality of DNA repair (HP:0003254)1.55615381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.76830966
2BCKDK4.43927161
3SMG14.35845523
4ERN14.19737687
5EPHA23.35390568
6AKT33.15067050
7FGFR43.12776522
8TESK22.98410343
9PKN22.81982501
10CDK72.72900925
11MAP4K12.72463720
12SIK12.39991859
13FLT32.38847523
14EEF2K2.30661096
15PRPF4B2.27504448
16TAOK32.13615089
17KDR1.92483672
18CDK121.90947799
19KIT1.63976060
20BTK1.59605087
21EIF2AK11.58431931
22TYK21.54936653
23DAPK31.54756492
24ZAP701.53830125
25TAOK21.52125248
26GRK61.51794264
27PTK61.48526984
28LRRK21.42191807
29STK161.38473864
30ARAF1.38235243
31MAP3K111.35262599
32TTK1.30151007
33BRAF1.24509231
34NME21.24230879
35TBK11.24148323
36BRD41.20296764
37AURKA1.18581405
38TTN1.17515362
39VRK21.15020454
40NTRK11.14157236
41JAK31.13396168
42BUB11.11948273
43NME11.11651014
44EIF2AK31.10172555
45ITK1.07631851
46CHEK21.05480810
47TGFBR11.03937831
48FGFR21.02784676
49TESK11.02393264
50PIM21.01853943
51ICK1.01840349
52EPHB11.00750980
53TIE11.00640614
54PRKD31.00281078
55AKT20.98913681
56CDK40.98529823
57IRAK30.98214523
58PBK0.97464072
59MST1R0.96396489
60PAK40.95643373
61MAPK110.92496370
62MAP3K100.91505425
63PIK3CG0.90402995
64TXK0.89736343
65NEK20.88094260
66WEE10.87717024
67LATS20.83781300
68DDR20.78744333
69PTK20.77914860
70MAP2K30.76841781
71MAP3K50.75976909
72CAMK1D0.75470628
73ILK0.74150350
74DYRK30.74065717
75SCYL20.73371040
76TGFBR20.73229789
77TEC0.71707134
78ACVR1B0.71668750
79TNK20.70889122
80MET0.67571415
81PRKCI0.66596162
82RPS6KA20.63702268
83MAPK30.63381004
84STK100.62373985
85ABL20.61239921
86CDC70.60023549
87MELK0.59522968
88CDK90.58571247
89MAP3K120.57467900
90BRSK10.57221372
91MAPK120.56117370
92NEK90.56012618
93TAF10.53949039
94RPS6KA50.53905176
95CHEK10.52466594
96MAP3K60.51454022
97KSR20.51174176
98PDPK10.50764504
99TLK10.49982179
100PRKD20.49933906
101VRK10.49769872
102CSF1R0.48662777
103PASK0.48505120
104RPS6KC10.47460194
105RPS6KL10.47460194
106MTOR0.47109626
107CDK80.46323063
108NEK10.46256063
109PLK10.46157538
110LCK0.45585557
111SYK0.45138776
112BLK0.45023893
113LYN0.43683975
114PAK10.42551336
115CDC42BPA0.41914709
116TSSK60.41870053
117SIK30.41377983
118MAP3K80.41365930
119MAP2K20.41277321
120MAP3K70.40161213
121JAK20.39850434
122NLK0.39385986
123PIM10.38719488
124CSNK1A1L0.36123493
125RPS6KA40.35406677
126HCK0.34691398
127DYRK1B0.34668777
128STK40.33592892
129IKBKE0.33418299
130BMX0.33085143
131CDK11A0.32638280
132SIK20.32463811
133SRPK10.31682026
134FGFR10.31438438
135CDK140.31239807
136TYRO30.29979520
137RIPK10.29915602
138CDK60.29774463
139ATR0.29366828
140LATS10.28852991
141MST40.28246507
142PDGFRA0.26650842
143MAPK10.25012592
144RPS6KB20.24650962
145MAPK150.23781890
146MAPKAPK30.22950901
147PRKG20.22055056
148AURKB0.21518250
149MAPKAPK50.21231889

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001405.61476130
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.40897765
3Fatty acid degradation_Homo sapiens_hsa000712.89863486
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.82272448
5Ovarian steroidogenesis_Homo sapiens_hsa049132.81351913
6Aldosterone synthesis and secretion_Homo sapiens_hsa049252.75871423
7Nitrogen metabolism_Homo sapiens_hsa009102.65288552
8Fatty acid metabolism_Homo sapiens_hsa012122.61242849
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51448479
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38084446
11p53 signaling pathway_Homo sapiens_hsa041152.25512024
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20575009
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15902400
14Tyrosine metabolism_Homo sapiens_hsa003502.13878737
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06939447
16Propanoate metabolism_Homo sapiens_hsa006402.05637839
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98753224
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98657268
19PPAR signaling pathway_Homo sapiens_hsa033201.89774999
20Tryptophan metabolism_Homo sapiens_hsa003801.77383598
21Arginine biosynthesis_Homo sapiens_hsa002201.74636538
22Peroxisome_Homo sapiens_hsa041461.73711446
23Sulfur relay system_Homo sapiens_hsa041221.65699611
24Bladder cancer_Homo sapiens_hsa052191.64246795
25Steroid biosynthesis_Homo sapiens_hsa001001.63285107
26Pyruvate metabolism_Homo sapiens_hsa006201.62872529
27Fat digestion and absorption_Homo sapiens_hsa049751.58385781
28Folate biosynthesis_Homo sapiens_hsa007901.55179971
29Vitamin digestion and absorption_Homo sapiens_hsa049771.53235995
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53028662
31Carbon metabolism_Homo sapiens_hsa012001.52833182
32Complement and coagulation cascades_Homo sapiens_hsa046101.49482154
33beta-Alanine metabolism_Homo sapiens_hsa004101.45721166
34Fatty acid elongation_Homo sapiens_hsa000621.44816440
35Fatty acid biosynthesis_Homo sapiens_hsa000611.42201442
36DNA replication_Homo sapiens_hsa030301.40422026
37Biosynthesis of amino acids_Homo sapiens_hsa012301.38463183
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36162291
39Bile secretion_Homo sapiens_hsa049761.35275769
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.33288089
41Histidine metabolism_Homo sapiens_hsa003401.33068441
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.31254112
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.28036124
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27113820
45Selenocompound metabolism_Homo sapiens_hsa004501.25810921
46Alcoholism_Homo sapiens_hsa050341.24728163
47Butanoate metabolism_Homo sapiens_hsa006501.13807397
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12866064
49Chronic myeloid leukemia_Homo sapiens_hsa052201.11278723
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11108820
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10438153
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09468368
53Viral carcinogenesis_Homo sapiens_hsa052031.08083584
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07417193
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06470359
56Chemical carcinogenesis_Homo sapiens_hsa052041.06393601
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05390271
58Pentose phosphate pathway_Homo sapiens_hsa000301.04923421
59Apoptosis_Homo sapiens_hsa042101.04902436
60One carbon pool by folate_Homo sapiens_hsa006701.02773154
61Cell cycle_Homo sapiens_hsa041100.99023959
62Caffeine metabolism_Homo sapiens_hsa002320.96935428
63Vibrio cholerae infection_Homo sapiens_hsa051100.89053325
64Lysine degradation_Homo sapiens_hsa003100.88154157
65Notch signaling pathway_Homo sapiens_hsa043300.83431097
66Staphylococcus aureus infection_Homo sapiens_hsa051500.83153991
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.81529880
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80677819
69Phenylalanine metabolism_Homo sapiens_hsa003600.80130320
70Thyroid cancer_Homo sapiens_hsa052160.79927647
71Sulfur metabolism_Homo sapiens_hsa009200.78246693
72Small cell lung cancer_Homo sapiens_hsa052220.78191964
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77720217
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73720715
75Non-small cell lung cancer_Homo sapiens_hsa052230.70570513
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69742225
77Arginine and proline metabolism_Homo sapiens_hsa003300.69092177
78Pancreatic cancer_Homo sapiens_hsa052120.68784702
79Glutathione metabolism_Homo sapiens_hsa004800.68174630
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68171033
81mRNA surveillance pathway_Homo sapiens_hsa030150.67332309
82Lysosome_Homo sapiens_hsa041420.65305600
83Retinol metabolism_Homo sapiens_hsa008300.65057358
84Mismatch repair_Homo sapiens_hsa034300.63870724
85Ribosome_Homo sapiens_hsa030100.63480474
86Glycerolipid metabolism_Homo sapiens_hsa005610.63109031
87RNA transport_Homo sapiens_hsa030130.63085358
88Metabolic pathways_Homo sapiens_hsa011000.61383443
89Basal cell carcinoma_Homo sapiens_hsa052170.61296075
90Primary immunodeficiency_Homo sapiens_hsa053400.60638471
91MicroRNAs in cancer_Homo sapiens_hsa052060.58847361
92ABC transporters_Homo sapiens_hsa020100.58728473
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58294097
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56980235
95VEGF signaling pathway_Homo sapiens_hsa043700.56098382
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55091300
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54628063
98Base excision repair_Homo sapiens_hsa034100.53805776
99Pyrimidine metabolism_Homo sapiens_hsa002400.53425775
100Proteoglycans in cancer_Homo sapiens_hsa052050.52953506
101Hepatitis C_Homo sapiens_hsa051600.51368423
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50305450
103Hippo signaling pathway_Homo sapiens_hsa043900.48730796
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48249013
105Prostate cancer_Homo sapiens_hsa052150.46992763
106Glioma_Homo sapiens_hsa052140.46865498
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.46405508
108ECM-receptor interaction_Homo sapiens_hsa045120.46335759
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45241073
110Insulin signaling pathway_Homo sapiens_hsa049100.44721956
111Hepatitis B_Homo sapiens_hsa051610.44178165
112Endometrial cancer_Homo sapiens_hsa052130.43612000
113Sphingolipid metabolism_Homo sapiens_hsa006000.42024902
114HTLV-I infection_Homo sapiens_hsa051660.40993782
115Hedgehog signaling pathway_Homo sapiens_hsa043400.40684584
116Shigellosis_Homo sapiens_hsa051310.40302136
117Acute myeloid leukemia_Homo sapiens_hsa052210.38751571
118Epstein-Barr virus infection_Homo sapiens_hsa051690.38536057
119Starch and sucrose metabolism_Homo sapiens_hsa005000.38362367
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35711083
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33532665
122Focal adhesion_Homo sapiens_hsa045100.33426510
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.33412532
124Antigen processing and presentation_Homo sapiens_hsa046120.33303139
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30200198
126N-Glycan biosynthesis_Homo sapiens_hsa005100.30172089
127Spliceosome_Homo sapiens_hsa030400.27973188
128Proteasome_Homo sapiens_hsa030500.26558748
129Nucleotide excision repair_Homo sapiens_hsa034200.22695721
130Insulin resistance_Homo sapiens_hsa049310.22268809
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.21694840
132Galactose metabolism_Homo sapiens_hsa000520.21006716
133Linoleic acid metabolism_Homo sapiens_hsa005910.20456009
134Fructose and mannose metabolism_Homo sapiens_hsa000510.19028571
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.16618293
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.15154252
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14605085
138Homologous recombination_Homo sapiens_hsa034400.13729188
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11644098
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.07359516
141Systemic lupus erythematosus_Homo sapiens_hsa053220.07304689
142Purine metabolism_Homo sapiens_hsa002300.05123661
143Herpes simplex infection_Homo sapiens_hsa051680.04636015
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02902910
145Other glycan degradation_Homo sapiens_hsa005110.02598587
146Vitamin B6 metabolism_Homo sapiens_hsa007500.00706113
147RNA polymerase_Homo sapiens_hsa03020-0.0178316
148Prion diseases_Homo sapiens_hsa05020-0.0030361

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