FECH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.94330383
2* protoporphyrinogen IX metabolic process (GO:0046501)9.83547098
3oxygen transport (GO:0015671)8.95550493
4gas transport (GO:0015669)8.14095947
5erythrocyte development (GO:0048821)7.60686301
6* porphyrin-containing compound biosynthetic process (GO:0006779)6.88383968
7* heme biosynthetic process (GO:0006783)6.42908603
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.33906811
9L-phenylalanine catabolic process (GO:0006559)6.33906811
10* tetrapyrrole biosynthetic process (GO:0033014)6.19846725
11L-phenylalanine metabolic process (GO:0006558)6.10102634
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.10102634
13iron ion import (GO:0097286)6.07838271
14* porphyrin-containing compound metabolic process (GO:0006778)6.05099202
15myeloid cell development (GO:0061515)5.82995575
16* heme metabolic process (GO:0042168)5.70980950
17cysteine metabolic process (GO:0006534)5.64825042
18lysine catabolic process (GO:0006554)5.56367791
19lysine metabolic process (GO:0006553)5.56367791
20aromatic amino acid family catabolic process (GO:0009074)5.47565867
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11273294
22hemoglobin metabolic process (GO:0020027)5.07352176
23glyoxylate metabolic process (GO:0046487)5.06437380
24hepatocyte apoptotic process (GO:0097284)4.98032017
25regulation of response to osmotic stress (GO:0047484)4.82453430
26alpha-linolenic acid metabolic process (GO:0036109)4.80677871
27kynurenine metabolic process (GO:0070189)4.79940809
28negative regulation of erythrocyte differentiation (GO:0045647)4.77892737
29tryptophan catabolic process (GO:0006569)4.72971983
30indole-containing compound catabolic process (GO:0042436)4.72971983
31indolalkylamine catabolic process (GO:0046218)4.72971983
32bile acid biosynthetic process (GO:0006699)4.59128021
33negative regulation of fibrinolysis (GO:0051918)4.54634681
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47962804
35tryptophan metabolic process (GO:0006568)4.47237567
36heme transport (GO:0015886)4.46064537
37megakaryocyte development (GO:0035855)4.42120320
38sulfur amino acid catabolic process (GO:0000098)4.40466300
39definitive hemopoiesis (GO:0060216)4.37050801
40positive regulation of granulocyte differentiation (GO:0030854)4.32839679
41peptidyl-glutamic acid carboxylation (GO:0017187)4.31659401
42protein carboxylation (GO:0018214)4.31659401
43amino-acid betaine metabolic process (GO:0006577)4.30385314
44regulation of triglyceride catabolic process (GO:0010896)4.30007277
45high-density lipoprotein particle remodeling (GO:0034375)4.29355260
46regulation of fibrinolysis (GO:0051917)4.27774846
47aspartate family amino acid catabolic process (GO:0009068)4.23460190
48regulation of protein activation cascade (GO:2000257)4.22432728
49complement activation, alternative pathway (GO:0006957)4.15252786
50urea cycle (GO:0000050)4.13980724
51urea metabolic process (GO:0019627)4.13980724
52* tetrapyrrole metabolic process (GO:0033013)4.10466376
53homocysteine metabolic process (GO:0050667)4.09424062
54cellular ketone body metabolic process (GO:0046950)4.08180740
55serine family amino acid catabolic process (GO:0009071)4.05429121
56erythrocyte maturation (GO:0043249)4.00077342
57plasma lipoprotein particle clearance (GO:0034381)3.98185434
58cofactor catabolic process (GO:0051187)3.96380265
59regulation of complement activation (GO:0030449)3.95876341
60alpha-amino acid catabolic process (GO:1901606)3.93752998
61regulation of RNA export from nucleus (GO:0046831)3.93125589
62ethanol oxidation (GO:0006069)3.92668507
63nitrogen cycle metabolic process (GO:0071941)3.91638606
64short-chain fatty acid metabolic process (GO:0046459)3.88012521
65aromatic amino acid family metabolic process (GO:0009072)3.86996353
66bile acid metabolic process (GO:0008206)3.86931524
67reverse cholesterol transport (GO:0043691)3.85642767
68serine family amino acid metabolic process (GO:0009069)3.85134738
69glutamate metabolic process (GO:0006536)3.82906358
70triglyceride homeostasis (GO:0070328)3.74924340
71acylglycerol homeostasis (GO:0055090)3.74924340
72acetyl-CoA metabolic process (GO:0006084)3.74208156
73protein-lipid complex remodeling (GO:0034368)3.70608922
74macromolecular complex remodeling (GO:0034367)3.70608922
75plasma lipoprotein particle remodeling (GO:0034369)3.70608922
76fatty acid beta-oxidation (GO:0006635)3.70388504
77cellular amino acid catabolic process (GO:0009063)3.67991041
78fatty acid oxidation (GO:0019395)3.67362859
79carnitine metabolic process (GO:0009437)3.66027865
80regulation of erythrocyte differentiation (GO:0045646)3.65905874
812-oxoglutarate metabolic process (GO:0006103)3.65559192
82phospholipid efflux (GO:0033700)3.64304969
83glycine metabolic process (GO:0006544)3.63329408
84tyrosine metabolic process (GO:0006570)3.62198326
85nuclear pore complex assembly (GO:0051292)3.62050757
86lipid oxidation (GO:0034440)3.59664306
87regulation of cholesterol esterification (GO:0010872)3.59460821
88cholesterol efflux (GO:0033344)3.57641975
89positive regulation of gamma-delta T cell activation (GO:0046645)3.54038922
90response to mercury ion (GO:0046689)3.53749429
91serine family amino acid biosynthetic process (GO:0009070)3.50921611
92ketone body metabolic process (GO:1902224)3.50411086
93drug transmembrane transport (GO:0006855)3.50329608
94embryonic hemopoiesis (GO:0035162)3.49269159
95coenzyme catabolic process (GO:0009109)3.48139438
96cellular modified amino acid catabolic process (GO:0042219)3.47505936
97granulocyte differentiation (GO:0030851)3.47283610
98blood coagulation, intrinsic pathway (GO:0007597)3.45962933
99N-terminal protein amino acid acetylation (GO:0006474)3.44988826
100fatty acid catabolic process (GO:0009062)3.44879023
101negative regulation of sterol transport (GO:0032372)3.40789978
102negative regulation of cholesterol transport (GO:0032375)3.40789978
103positive regulation of triglyceride lipase activity (GO:0061365)3.40028328
104positive regulation of lipoprotein lipase activity (GO:0051006)3.40028328
105positive regulation of erythrocyte differentiation (GO:0045648)3.38321224
106carboxylic acid catabolic process (GO:0046395)3.37217472
107organic acid catabolic process (GO:0016054)3.37217472
108* plasma lipoprotein particle assembly (GO:0034377)3.36959687
109valine metabolic process (GO:0006573)3.36822515
110monocarboxylic acid catabolic process (GO:0072329)3.36039610
111response to nitrosative stress (GO:0051409)3.35537801
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.35144427
113dicarboxylic acid biosynthetic process (GO:0043650)3.34504621
114arginine metabolic process (GO:0006525)3.32274452
115positive regulation of fatty acid beta-oxidation (GO:0032000)3.32230261
116positive regulation of lipid catabolic process (GO:0050996)3.31876394
117amine catabolic process (GO:0009310)3.26470971
118cellular biogenic amine catabolic process (GO:0042402)3.26470971
119benzene-containing compound metabolic process (GO:0042537)3.24418547
120indolalkylamine metabolic process (GO:0006586)3.24047187
121regulation of nucleobase-containing compound transport (GO:0032239)3.22548807
122positive regulation of receptor recycling (GO:0001921)3.21199300
123positive regulation of cellular response to oxidative stress (GO:1900409)3.20451914
124positive regulation of response to oxidative stress (GO:1902884)3.20451914
125microglial cell activation (GO:0001774)3.13317675
126platelet formation (GO:0030220)3.11722523
127regulation of platelet aggregation (GO:0090330)3.07197587
128mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.05927513
129positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.05927513
1303-UTR-mediated mRNA stabilization (GO:0070935)3.05655902
131* erythrocyte differentiation (GO:0030218)3.03193857
132negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.02999343
133cellular response to arsenic-containing substance (GO:0071243)2.99071266
134regulation of oxidative phosphorylation (GO:0002082)2.97501112
135regulation of inositol phosphate biosynthetic process (GO:0010919)2.96465772
136* pigment biosynthetic process (GO:0046148)2.95481103
137nuclear pore organization (GO:0006999)2.95333834
138mitochondrion degradation (GO:0000422)2.94328124
139positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.91496442
140cellular response to thyroid hormone stimulus (GO:0097067)2.90906400
141protein K11-linked deubiquitination (GO:0035871)2.89435405
142glycine transport (GO:0015816)2.88257137
143negative regulation of histone acetylation (GO:0035067)2.86194158
144histone mRNA catabolic process (GO:0071044)2.84073637
145pore complex assembly (GO:0046931)2.80375267
146one-carbon compound transport (GO:0019755)2.79065816
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75854960
148phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.71970913
149* pigment metabolic process (GO:0042440)2.69979059
150negative regulation of execution phase of apoptosis (GO:1900118)2.69702369
151dopamine transport (GO:0015872)2.69101637
152dosage compensation (GO:0007549)2.68304479
153positive regulation of B cell differentiation (GO:0045579)2.64189278
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.63864004
155regulation of granulocyte differentiation (GO:0030852)2.63035489
156response to iron ion (GO:0010039)2.62365248
157negative regulation of peptidyl-lysine acetylation (GO:2000757)2.59758569
158regulation of B cell receptor signaling pathway (GO:0050855)2.58700207
159hemopoiesis (GO:0030097)2.56665025
160actin filament capping (GO:0051693)2.54433339
161regulation of acyl-CoA biosynthetic process (GO:0050812)2.53440133
162pentose-phosphate shunt (GO:0006098)2.53029802
163* response to arsenic-containing substance (GO:0046685)2.52774258
164regulation of gamma-delta T cell differentiation (GO:0045586)2.52635023
165histone H3-K36 demethylation (GO:0070544)2.51760044
166regulation of receptor recycling (GO:0001919)2.50715968
167DNA topological change (GO:0006265)2.49641877
168negative regulation of protein acetylation (GO:1901984)2.47489713
169cellular response to virus (GO:0098586)2.47105722
170response to thyroid hormone (GO:0097066)2.46429837
171ovulation from ovarian follicle (GO:0001542)2.44487640
172neutrophil activation involved in immune response (GO:0002283)2.44128926
173negative regulation of necroptotic process (GO:0060546)2.43416452
174neutrophil mediated immunity (GO:0002446)2.41013346
175hydrogen peroxide catabolic process (GO:0042744)2.40758772
176regulation of necroptotic process (GO:0060544)2.40383801
177positive regulation of mitochondrial membrane permeability (GO:0035794)2.40075529
178protein export from nucleus (GO:0006611)2.39987546
179NADPH regeneration (GO:0006740)2.37567868
180negative regulation of protein localization to plasma membrane (GO:1903077)2.36508626
181regulation of response to reactive oxygen species (GO:1901031)2.36498902
182myeloid leukocyte mediated immunity (GO:0002444)2.35898188
183cellular hyperosmotic response (GO:0071474)2.34083424
184protein K48-linked deubiquitination (GO:0071108)2.33840822
185modulation by virus of host process (GO:0019054)2.33830804
186monoubiquitinated protein deubiquitination (GO:0035520)2.32070869
187regulation of beta-amyloid formation (GO:1902003)2.31872318
188positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.31428167
189cellular response to gamma radiation (GO:0071480)2.30774459
190cellular response to epinephrine stimulus (GO:0071872)2.26460591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.65416816
2E2F7_22180533_ChIP-Seq_HELA_Human6.54921614
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.52121065
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.74701815
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.45607029
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.41669711
7GATA1_22025678_ChIP-Seq_K562_Human5.12422609
8* LXR_22158963_ChIP-Seq_LIVER_Mouse4.97761843
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08826339
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.93952541
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62379288
12GATA1_19941826_ChIP-Seq_K562_Human3.37858929
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24051510
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.07408911
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.97387825
16* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.71281179
17* GATA1_19941827_ChIP-Seq_MEL_Mouse2.70744174
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57323821
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45418635
20KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.43567173
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38511033
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27090723
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09440661
24TFEB_21752829_ChIP-Seq_HELA_Human2.09050670
25* GATA2_19941826_ChIP-Seq_K562_Human1.99165799
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83451302
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78692587
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78514105
29* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77174226
30ZNF263_19887448_ChIP-Seq_K562_Human1.76987380
31* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70217538
32CLOCK_20551151_ChIP-Seq_293T_Human1.69666473
33SCL_19346495_ChIP-Seq_HPC-7_Human1.69072456
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67973404
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62944601
36MYC_22102868_ChIP-Seq_BL_Human1.61967877
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.58159050
38* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56890283
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56867723
40* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55870741
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48068690
42MYB_26560356_Chip-Seq_TH1_Human1.46812524
43CHD1_26751641_Chip-Seq_LNCaP_Human1.45494040
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45010236
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43200037
46MYB_26560356_Chip-Seq_TH2_Human1.42984461
47SPI1_23547873_ChIP-Seq_NB4_Human1.40769320
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40158127
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39424962
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37417961
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35322198
52MAF_26560356_Chip-Seq_TH1_Human1.34176634
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32796444
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.32282056
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.28784955
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28167754
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.27815318
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27463800
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26084075
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25590418
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25147947
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24961579
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.24128896
64SPI1_23127762_ChIP-Seq_K562_Human1.23248028
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23121164
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23029261
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21349168
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20965463
69FOXP3_21729870_ChIP-Seq_TREG_Human1.20920744
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.20487367
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19666346
72TCF7_22412390_ChIP-Seq_EML_Mouse1.19390818
73PU_27001747_Chip-Seq_BMDM_Mouse1.18432878
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16866421
75VDR_21846776_ChIP-Seq_THP-1_Human1.16608407
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13910207
77* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13796957
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.13403680
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12457649
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.12344358
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11742511
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10886420
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10493687
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.08725788
85VDR_24763502_ChIP-Seq_THP-1_Human1.08172417
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07016539
87HNF4A_19822575_ChIP-Seq_HepG2_Human1.06541099
88* VDR_23849224_ChIP-Seq_CD4+_Human1.04784457
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03263325
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03232924
91ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03189350
92SALL4_22934838_ChIP-ChIP_CD34+_Human1.02745639
93DCP1A_22483619_ChIP-Seq_HELA_Human1.02668856
94KDM5A_27292631_Chip-Seq_BREAST_Human1.01245952
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00937902
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99005382
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98639889
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98615846
99CIITA_25753668_ChIP-Seq_RAJI_Human0.98282468
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98100756
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96582931
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96518037
103RUNX_20019798_ChIP-Seq_JUKART_Human0.96368392
104UTX_26944678_Chip-Seq_JUKART_Human0.94882792
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92292369
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92149254
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91389025
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89734677
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89148901
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89095818
111GATA3_27048872_Chip-Seq_THYMUS_Human0.88897577
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85791211
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85764296
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.85685428
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85392594
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84722597
117TRIM28_21343339_ChIP-Seq_HEK293_Human0.83783065
118GATA4_25053715_ChIP-Seq_YYC3_Human0.83359840
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83096789
120HTT_18923047_ChIP-ChIP_STHdh_Human0.78917157
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78836018
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78597431
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78003109
124AR_21909140_ChIP-Seq_LNCAP_Human0.77546585
125NCOR1_26117541_ChIP-Seq_K562_Human0.76937324
126* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76439223
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76125904
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75811547
129* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75587471
130* LXR_22292898_ChIP-Seq_THP-1_Human0.75021963
131* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74250064
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73689282
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73679205
134* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72985315
135GATA6_25053715_ChIP-Seq_YYC3_Human0.72427202
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71904458
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70981843
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70967522
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.69123205
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68708243
141BCOR_27268052_Chip-Seq_Bcells_Human0.67748678
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65028461
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.63523853
144ATF3_27146783_Chip-Seq_COLON_Human0.63362787
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.61740787
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61358285
147* CTCF_21964334_Chip-Seq_Bcells_Human0.61323969
148* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.61142242
149P68_20966046_ChIP-Seq_HELA_Human0.61094579
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60245004
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.60114775
152* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59068590
153* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59043458
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58740908
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.58716815
156* SRF_21415370_ChIP-Seq_HL-1_Mouse0.58707316
157* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.58642805
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.57297939
159TBX20_22080862_ChIP-Seq_HEART_Mouse0.57297939
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57245021
161CTCF_27219007_Chip-Seq_ERYTHROID_Human0.57011430
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.56803406
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.56608697
164BCL6_27268052_Chip-Seq_Bcells_Human0.56476782
165SPI1_20517297_ChIP-Seq_HL60_Human0.54653324
166RACK7_27058665_Chip-Seq_MCF-7_Human0.53602403
167TBX5_21415370_ChIP-Seq_HL-1_Mouse0.53575999
168RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53357024
169FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.53058196
170ELK3_25401928_ChIP-Seq_HUVEC_Human0.52845684
171FOXA1_25552417_ChIP-Seq_VCAP_Human0.52268634
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.51590357
173CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49717957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.66257925
2* MP0003656_abnormal_erythrocyte_physiolo6.15542525
3MP0005360_urolithiasis5.97553882
4MP0004147_increased_porphyrin_level5.69674819
5MP0005085_abnormal_gallbladder_physiolo4.98825665
6MP0005365_abnormal_bile_salt4.44088696
7MP0003806_abnormal_nucleotide_metabolis3.97877345
8MP0005083_abnormal_biliary_tract3.93957542
9MP0008875_abnormal_xenobiotic_pharmacok3.80505656
10MP0003252_abnormal_bile_duct3.00394234
11MP0003195_calcinosis2.84057990
12MP0010329_abnormal_lipoprotein_level2.80225323
13MP0009840_abnormal_foam_cell2.62357270
14MP0008057_abnormal_DNA_replication2.46450088
15MP0000015_abnormal_ear_pigmentation2.39611618
16MP0005332_abnormal_amino_acid2.39197841
17MP0005075_abnormal_melanosome_morpholog2.19362212
18MP0003172_abnormal_lysosome_physiology2.13162313
19MP0001666_abnormal_nutrient_absorption2.04976184
20MP0003191_abnormal_cellular_cholesterol2.03776189
21MP0005636_abnormal_mineral_homeostasis1.96968927
22* MP0000609_abnormal_liver_physiology1.95065792
23MP0006036_abnormal_mitochondrial_physio1.93838564
24MP0000569_abnormal_digit_pigmentation1.92786976
25MP0002396_abnormal_hematopoietic_system1.91164733
26MP0002118_abnormal_lipid_homeostasis1.88901768
27MP0003186_abnormal_redox_activity1.85598283
28MP0004808_abnormal_hematopoietic_stem1.82011774
29MP0002166_altered_tumor_susceptibility1.72912037
30MP0003111_abnormal_nucleus_morphology1.71717355
31MP0002837_dystrophic_cardiac_calcinosis1.68505749
32MP0003303_peritoneal_inflammation1.66991432
33MP0005584_abnormal_enzyme/coenzyme_acti1.64362105
34MP0002138_abnormal_hepatobiliary_system1.63095498
35* MP0005319_abnormal_enzyme/_coenzyme1.60296125
36MP0000372_irregular_coat_pigmentation1.59340574
37MP0008995_early_reproductive_senescence1.58932482
38MP0004381_abnormal_hair_follicle1.53182138
39MP0004130_abnormal_muscle_cell1.53021684
40MP0005174_abnormal_tail_pigmentation1.49040509
41MP0004019_abnormal_vitamin_homeostasis1.47283925
42MP0009643_abnormal_urine_homeostasis1.46840477
43MP0002877_abnormal_melanocyte_morpholog1.45388149
44MP0000749_muscle_degeneration1.40058703
45MP0001764_abnormal_homeostasis1.39986377
46* MP0002398_abnormal_bone_marrow1.36466230
47MP0002009_preneoplasia1.35506530
48MP0002095_abnormal_skin_pigmentation1.33392611
49MP0003763_abnormal_thymus_physiology1.30062394
50MP0003705_abnormal_hypodermis_morpholog1.29503361
51MP0009278_abnormal_bone_marrow1.27916324
52MP0003077_abnormal_cell_cycle1.26295265
53MP0010307_abnormal_tumor_latency1.26196422
54* MP0000689_abnormal_spleen_morphology1.25456029
55MP0010094_abnormal_chromosome_stability1.25158065
56* MP0002722_abnormal_immune_system1.25009398
57MP0003868_abnormal_feces_composition1.23861154
58MP0005171_absent_coat_pigmentation1.22018778
59MP0000371_diluted_coat_color1.17935199
60* MP0000598_abnormal_liver_morphology1.10898973
61MP0008775_abnormal_heart_ventricle1.09481283
62MP0000703_abnormal_thymus_morphology1.09079667
63MP0004043_abnormal_pH_regulation1.06905869
64MP0004957_abnormal_blastocyst_morpholog1.06119736
65MP0003786_premature_aging1.05204212
66MP0009764_decreased_sensitivity_to1.03338338
67MP0000685_abnormal_immune_system1.02678727
68MP0005666_abnormal_adipose_tissue1.01797737
69MP0002971_abnormal_brown_adipose1.01077960
70MP0003646_muscle_fatigue0.99255476
71MP0009763_increased_sensitivity_to0.97575178
72MP0005451_abnormal_body_composition0.97310854
73MP0005187_abnormal_penis_morphology0.96145644
74MP0005670_abnormal_white_adipose0.96093072
75* MP0002429_abnormal_blood_cell0.95243188
76MP0008058_abnormal_DNA_repair0.94822232
77MP0005621_abnormal_cell_physiology0.91708034
78MP0002006_tumorigenesis0.91042848
79MP0003011_delayed_dark_adaptation0.90300509
80MP0000747_muscle_weakness0.89162011
81MP0002078_abnormal_glucose_homeostasis0.88718465
82MP0005310_abnormal_salivary_gland0.88342223
83MP0004233_abnormal_muscle_weight0.88280885
84MP0009697_abnormal_copulation0.87866508
85MP0002019_abnormal_tumor_incidence0.87320825
86MP0004185_abnormal_adipocyte_glucose0.87137456
87MP0000604_amyloidosis0.86015807
88MP0006035_abnormal_mitochondrial_morpho0.85852599
89MP0001730_embryonic_growth_arrest0.84654915
90MP0005384_cellular_phenotype0.84267246
91MP0005535_abnormal_body_temperature0.83399333
92MP0000313_abnormal_cell_death0.82800047
93MP0005330_cardiomyopathy0.82511396
94MP0002269_muscular_atrophy0.82348421
95MP0001756_abnormal_urination0.81806345
96MP0005334_abnormal_fat_pad0.80033514
97MP0009765_abnormal_xenobiotic_induced0.79356853
98MP0003828_pulmonary_edema0.78325912
99MP0005076_abnormal_cell_differentiation0.78105214
100* MP0009642_abnormal_blood_homeostasis0.77293316
101MP0004215_abnormal_myocardial_fiber0.76219184
102MP0005376_homeostasis/metabolism_phenot0.76085195
103MP0002405_respiratory_system_inflammati0.75046678
104MP0001661_extended_life_span0.74918125
105MP0005464_abnormal_platelet_physiology0.74459025
106MP0005266_abnormal_metabolism0.74025134
107MP0004145_abnormal_muscle_electrophysio0.72630441
108MP0010368_abnormal_lymphatic_system0.72362033
109MP0004036_abnormal_muscle_relaxation0.71452069
110MP0004484_altered_response_of0.70819113
111MP0001835_abnormal_antigen_presentation0.70437337
112MP0003984_embryonic_growth_retardation0.70145642
113MP0005397_hematopoietic_system_phenotyp0.69786829
114MP0001545_abnormal_hematopoietic_system0.69786829
115MP0002088_abnormal_embryonic_growth/wei0.69278873
116MP0001915_intracranial_hemorrhage0.69014263
117MP0000716_abnormal_immune_system0.68673198
118MP0003329_amyloid_beta_deposits0.68376240
119MP0002086_abnormal_extraembryonic_tissu0.68279604
120MP0009333_abnormal_splenocyte_physiolog0.67779253
121* MP0008469_abnormal_protein_level0.67198129
122MP0005647_abnormal_sex_gland0.66156061
123MP0000858_altered_metastatic_potential0.65650300
124MP0005025_abnormal_response_to0.65483950
125MP0004883_abnormal_blood_vessel0.65131139
126MP0000350_abnormal_cell_proliferation0.64946350
127MP0008872_abnormal_physiological_respon0.64519887
128MP0000358_abnormal_cell_content/0.64287518
129MP0002419_abnormal_innate_immunity0.64062701
130* MP0002080_prenatal_lethality0.64058190
131MP0001672_abnormal_embryogenesis/_devel0.62576954
132MP0005380_embryogenesis_phenotype0.62576954
133MP0003300_gastrointestinal_ulcer0.61679576
134MP0008877_abnormal_DNA_methylation0.61540768
135MP0005375_adipose_tissue_phenotype0.61375922
136MP0004087_abnormal_muscle_fiber0.61365434
137MP0001697_abnormal_embryo_size0.61158867
138MP0002420_abnormal_adaptive_immunity0.61099571
139MP0006054_spinal_hemorrhage0.58821721
140MP0005620_abnormal_muscle_contractility0.58505269
141MP0003221_abnormal_cardiomyocyte_apopto0.58454113
142MP0009931_abnormal_skin_appearance0.57565261
143MP0008438_abnormal_cutaneous_collagen0.56302658
144MP0001765_abnormal_ion_homeostasis0.55561915
145MP0002972_abnormal_cardiac_muscle0.55307849
146MP0002970_abnormal_white_adipose0.54926155
147MP0002136_abnormal_kidney_physiology0.54722859
148MP0000230_abnormal_systemic_arterial0.53934522
149MP0005448_abnormal_energy_balance0.53575038
150MP0005385_cardiovascular_system_phenoty0.51618745
151MP0001544_abnormal_cardiovascular_syste0.51618745
152MP0008260_abnormal_autophagy0.51301717
153MP0002132_abnormal_respiratory_system0.49737317
154MP0003690_abnormal_glial_cell0.49485524
155MP0004084_abnormal_cardiac_muscle0.49349907
156MP0000759_abnormal_skeletal_muscle0.48687862
157MP0005220_abnormal_exocrine_pancreas0.48492460
158MP0005058_abnormal_lysosome_morphology0.47927036
159MP0002332_abnormal_exercise_endurance0.47762675
160MP0003075_altered_response_to0.45665464
161MP0000751_myopathy0.44750980
162MP0009053_abnormal_anal_canal0.43808017
163MP0001243_abnormal_dermal_layer0.42787334
164MP0005408_hypopigmentation0.39913116
165MP0010630_abnormal_cardiac_muscle0.39801175
166MP0005084_abnormal_gallbladder_morpholo0.38483302

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)7.82848048
2Poikilocytosis (HP:0004447)7.73042897
3Acanthocytosis (HP:0001927)6.23469905
4Hypochromic microcytic anemia (HP:0004840)6.21024003
5Reticulocytosis (HP:0001923)5.39818973
6Hyperbilirubinemia (HP:0002904)5.25633315
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.16100873
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.07820022
9Deep venous thrombosis (HP:0002625)5.02630249
10Intrahepatic cholestasis (HP:0001406)4.94698233
11* Cholelithiasis (HP:0001081)4.91181712
12Abnormal hemoglobin (HP:0011902)4.81208651
13Xanthomatosis (HP:0000991)4.74635900
14* Abnormal gallbladder morphology (HP:0012437)4.65729876
15Cholecystitis (HP:0001082)4.29948843
16Abnormal gallbladder physiology (HP:0012438)4.29948843
17Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25708701
18Prolonged partial thromboplastin time (HP:0003645)4.14957172
19Hypobetalipoproteinemia (HP:0003563)4.13809643
20Hyperlipoproteinemia (HP:0010980)3.94134549
21Hyperammonemia (HP:0001987)3.74180689
22Paralysis (HP:0003470)3.71682209
23Ketosis (HP:0001946)3.68063780
24Hypoglycemic coma (HP:0001325)3.67840511
25Diaphragmatic weakness (HP:0009113)3.64051558
26Hypolipoproteinemia (HP:0010981)3.55965768
27Complement deficiency (HP:0004431)3.55750471
28Hypoalphalipoproteinemia (HP:0003233)3.46775623
29Hepatocellular carcinoma (HP:0001402)3.45231520
30* Abnormality of the gallbladder (HP:0005264)3.37168155
31Orthostatic hypotension (HP:0001278)3.32380753
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30324962
33Abnormality of fatty-acid metabolism (HP:0004359)3.28657277
34Prolonged bleeding time (HP:0003010)3.16745791
35Abnormality of glycine metabolism (HP:0010895)3.15258612
36Abnormality of serine family amino acid metabolism (HP:0010894)3.15258612
37Abnormality of reticulocytes (HP:0004312)3.13305421
38Hyperglycinemia (HP:0002154)3.13038201
39Abnormality of the common coagulation pathway (HP:0010990)3.12694795
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.09000943
41Hyperglycinuria (HP:0003108)3.07668826
42Visual hallucinations (HP:0002367)3.07592892
43Joint hemorrhage (HP:0005261)3.04856242
44Toxemia of pregnancy (HP:0100603)3.01405921
45Metabolic acidosis (HP:0001942)3.01331003
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98950423
47Slow saccadic eye movements (HP:0000514)2.97622744
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94352909
49Ketoacidosis (HP:0001993)2.92440760
50Epidermoid cyst (HP:0200040)2.91927005
51Polycythemia (HP:0001901)2.90342721
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87528761
53Ileus (HP:0002595)2.86470488
54Abnormality of methionine metabolism (HP:0010901)2.81578683
55Nausea (HP:0002018)2.78404321
56Hypochromic anemia (HP:0001931)2.76361487
57Abnormality of iron homeostasis (HP:0011031)2.70616148
58Fat malabsorption (HP:0002630)2.67642864
59Dicarboxylic aciduria (HP:0003215)2.67282591
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67282591
61Increased serum ferritin (HP:0003281)2.67070977
62Papillary thyroid carcinoma (HP:0002895)2.65802953
63Abnormality of the fingertips (HP:0001211)2.65287393
64Abnormality of the intrinsic pathway (HP:0010989)2.65245865
65Abnormality of complement system (HP:0005339)2.63926641
66Gastrointestinal infarctions (HP:0005244)2.62909807
67Abnormality of transition element cation homeostasis (HP:0011030)2.57614785
68Recurrent bacterial skin infections (HP:0005406)2.44160833
69Abnormality of purine metabolism (HP:0004352)2.42055346
70Hypercholesterolemia (HP:0003124)2.41971244
71Gout (HP:0001997)2.41665917
72Myoglobinuria (HP:0002913)2.37808320
73Osteomalacia (HP:0002749)2.36294235
74Cerebral edema (HP:0002181)2.36264435
75Generalized aminoaciduria (HP:0002909)2.36189791
76Vomiting (HP:0002013)2.33839338
77Abnormality of nucleobase metabolism (HP:0010932)2.33691234
78Epistaxis (HP:0000421)2.32770874
79Abnormality of serum amino acid levels (HP:0003112)2.32159967
80Recurrent abscess formation (HP:0002722)2.29549078
81Global brain atrophy (HP:0002283)2.28904712
82Lethargy (HP:0001254)2.28445928
83Cerebral palsy (HP:0100021)2.24476865
84Gingival bleeding (HP:0000225)2.24211033
85Thyroid carcinoma (HP:0002890)2.22512298
86T lymphocytopenia (HP:0005403)2.22108577
87Delayed CNS myelination (HP:0002188)2.20277162
88Increased mean platelet volume (HP:0011877)2.18104092
89Abnormality of pyrimidine metabolism (HP:0004353)2.16963010
90Rickets (HP:0002748)2.12943112
91Myocardial infarction (HP:0001658)2.12700925
92Albinism (HP:0001022)2.12640593
93Fatigue (HP:0012378)2.09872038
94Confusion (HP:0001289)2.09458554
95Abnormal platelet volume (HP:0011876)2.07199945
96Spontaneous hematomas (HP:0007420)2.07197943
97Abnormality of T cell number (HP:0011839)2.05867629
98Autoimmune hemolytic anemia (HP:0001890)2.05247660
99Skin nodule (HP:0200036)2.04700906
100Recurrent viral infections (HP:0004429)2.02795428
101Conjunctival telangiectasia (HP:0000524)2.01801504
102Insomnia (HP:0100785)2.01541188
103Brushfield spots (HP:0001088)1.99856005
104Steatorrhea (HP:0002570)1.99680342
105Long clavicles (HP:0000890)1.99437864
106Nonimmune hydrops fetalis (HP:0001790)1.96524445
107Acute myeloid leukemia (HP:0004808)1.96344794
108Hypoglycemic seizures (HP:0002173)1.95094076
109Postural instability (HP:0002172)1.93786167
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93405271
111Autoamputation (HP:0001218)1.93370813
112Rhabdomyolysis (HP:0003201)1.93289518
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.92368812
114Osteolytic defects of the hand bones (HP:0009699)1.92368812
115Conjugated hyperbilirubinemia (HP:0002908)1.92184950
116Osteomyelitis (HP:0002754)1.90066006
117Hepatic necrosis (HP:0002605)1.89255486
118Hemorrhage of the eye (HP:0011885)1.87510101
119Spontaneous abortion (HP:0005268)1.86800014
120Viral hepatitis (HP:0006562)1.85498236
121Dysautonomia (HP:0002459)1.84817170
122* Microcytic anemia (HP:0001935)1.84202625
123Sensorimotor neuropathy (HP:0007141)1.84146265
124* Cutaneous photosensitivity (HP:0000992)1.83612242
125Late onset (HP:0003584)1.81522229
126Testicular neoplasm (HP:0010788)1.80608712
127Ocular albinism (HP:0001107)1.80129879
128Hyperinsulinemic hypoglycemia (HP:0000825)1.78919441
129Irritability (HP:0000737)1.78138275
130Vascular calcification (HP:0004934)1.77505952
131Subacute progressive viral hepatitis (HP:0006572)1.77288113
132Increased purine levels (HP:0004368)1.76175354
133Hyperuricemia (HP:0002149)1.76175354
134Lower limb hyperreflexia (HP:0002395)1.75061060
135Exercise-induced muscle cramps (HP:0003710)1.74780290
136Resting tremor (HP:0002322)1.74219242
137Proximal tubulopathy (HP:0000114)1.73201694
138Cerebral inclusion bodies (HP:0100314)1.72535711
139Anhidrosis (HP:0000970)1.72261572
140Abnormality of the Achilles tendon (HP:0005109)1.72202575
141Abnormal platelet function (HP:0011869)1.72091091
142Impaired platelet aggregation (HP:0003540)1.72091091
143Abnormal cartilage morphology (HP:0002763)1.71808850
144Petechiae (HP:0000967)1.70946351
145Thrombophlebitis (HP:0004418)1.70868367
146Glycosuria (HP:0003076)1.70446441
147Abnormality of urine glucose concentration (HP:0011016)1.70446441
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.68584810
149Hypertensive crisis (HP:0100735)1.67258587
150Recurrent fungal infections (HP:0002841)1.65977979
151Muscle fibrillation (HP:0010546)1.65934394
152Pustule (HP:0200039)1.65444709
153Autoimmune thrombocytopenia (HP:0001973)1.62074073
154Difficulty running (HP:0009046)1.59887953
155Abnormality of saccadic eye movements (HP:0000570)1.59235693
156Anorexia (HP:0002039)1.57875244
157Abnormality of T cells (HP:0002843)1.55809403
158Arterial thrombosis (HP:0004420)1.55653845
159Pallor (HP:0000980)1.55560434
160Eczematoid dermatitis (HP:0000976)1.55501106
161Recurrent skin infections (HP:0001581)1.53970685
162Acute hepatic failure (HP:0006554)1.53848667
163Germ cell neoplasia (HP:0100728)1.53696768
164Cutaneous melanoma (HP:0012056)1.53101556
165Aplasia/Hypoplasia of the earlobes (HP:0009906)1.50260989
166Hyponatremia (HP:0002902)1.50252262
167Gingivitis (HP:0000230)1.49446321
168Gonadal dysgenesis (HP:0000133)1.46732344
169Splenomegaly (HP:0001744)1.45923705
170Increased connective tissue (HP:0009025)1.45382576
171Recurrent cutaneous fungal infections (HP:0011370)1.44837261
172Chronic mucocutaneous candidiasis (HP:0002728)1.44837261
173Inflammation of the large intestine (HP:0002037)1.43607334
174Delusions (HP:0000746)1.42640610
175Hypoparathyroidism (HP:0000829)1.42573193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.58801479
2EIF2AK15.52357399
3PRPF4B3.25347949
4TRIB33.21921497
5TLK12.96549272
6STK42.51632463
7ERN12.49246350
8PKN22.43489597
9SIK12.35208286
10TAOK32.26581633
11MAPK112.14832843
12RIPK42.09376448
13WNK12.05014285
14PLK21.98840497
15FGR1.92931880
16TTN1.69593178
17CLK11.68013281
18FGFR41.66960820
19SMG11.59471780
20PLK31.58466143
21MAP2K31.57479164
22FLT31.57299617
23PIK3CG1.55428985
24ZAK1.53719849
25ABL21.53254748
26NME21.52066710
27MARK31.51526137
28MAP3K111.50614087
29OBSCN1.49543891
30NEK11.44235991
31INSRR1.42343422
32NEK91.41488063
33JAK21.32625402
34WNK41.29954652
35PINK11.27363957
36PRKAA11.26722346
37PRKAA21.26539048
38BRSK11.24970738
39RAF11.24019077
40KSR11.15828253
41IKBKE1.15647826
42NUAK11.15468779
43MAPKAPK31.09537428
44TAF11.09230298
45TRPM71.05794999
46PDK41.04254880
47PDK31.04254880
48ERBB21.03384962
49BLK1.03276668
50TGFBR21.03065017
51DYRK1B1.02844237
52TEC1.00485629
53MAP3K21.00370414
54MAP3K80.98933521
55STK100.98635652
56MAP2K40.98201471
57EIF2AK30.95365098
58KDR0.95289531
59GRK60.94611508
60MET0.92157207
61MAP2K10.90988350
62DAPK20.89935214
63MAP3K70.89654034
64KSR20.89134890
65MAPK120.88868911
66CDK60.88045294
67CAMK1D0.86650789
68TYK20.84488058
69PBK0.84403453
70MST1R0.83853773
71CAMK1G0.82184918
72JAK30.77787607
73PHKG20.77325926
74PHKG10.77325926
75BMPR20.77054494
76PTK2B0.76661795
77PRKACG0.76432136
78PIM10.75893588
79RPS6KA50.75892558
80SCYL20.74808391
81MAPKAPK50.74523832
82SGK2230.73063351
83SGK4940.73063351
84HIPK20.71822431
85TAOK10.71463797
86PKN10.70802713
87DYRK30.70437171
88PIK3CA0.69359124
89CDK120.68801890
90MST40.68526616
91SGK30.68283980
92MAP3K30.67773459
93BMX0.67519772
94EPHB10.67154572
95PDPK10.66497009
96BTK0.65247657
97MAP3K100.65135757
98ERBB40.64371369
99PTK60.63845390
100TBK10.60512886
101BRD40.58474615
102TIE10.58414904
103DYRK1A0.55615005
104LRRK20.52740749
105CDK40.51835839
106LYN0.51655757
107BRSK20.50573407
108TAOK20.50513318
109AKT30.50458889
110ICK0.49435918
111HCK0.49065730
112RET0.48971445
113SGK10.48757690
114FGFR30.45545930
115PDK10.45150837
116AURKA0.44942282
117TNK20.44036759
118VRK10.43925362
119IRAK40.43705644
120MAP3K60.43662497
121EEF2K0.43292468
122YES10.42035831
123GRK70.40862414
124DAPK30.40188399
125STK30.39992552
126ACVR1B0.38299511
127CHEK10.37007471
128MAP3K50.36803985
129MYLK0.36579794
130MELK0.36321829
131ZAP700.36044914
132PLK10.36036081
133STK110.35625985
134RPS6KB20.35126704
135IRAK10.34373140
136CSK0.33645501
137AKT20.33590859
138ATM0.32538826
139SGK20.32391238
140MAP3K10.31673865
141AURKB0.31493469
142FES0.31027913
143GRK50.30998661
144BUB10.29899716
145MTOR0.29839295
146SYK0.29302984
147CDK90.29088626
148PRKACB0.28231208
149IRAK30.28160844
150AKT10.27628793

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.56815954
2* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.24163590
3Nitrogen metabolism_Homo sapiens_hsa009103.23443890
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07009267
5Non-small cell lung cancer_Homo sapiens_hsa052233.01444324
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78839028
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78185384
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76874512
9Fatty acid degradation_Homo sapiens_hsa000712.71241395
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59368383
11Arginine biosynthesis_Homo sapiens_hsa002202.51678636
12Tryptophan metabolism_Homo sapiens_hsa003802.41279059
13Propanoate metabolism_Homo sapiens_hsa006402.39880611
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37219250
15Vitamin B6 metabolism_Homo sapiens_hsa007502.34941654
16Complement and coagulation cascades_Homo sapiens_hsa046102.17157751
17Butanoate metabolism_Homo sapiens_hsa006502.12084766
18Pancreatic cancer_Homo sapiens_hsa052122.11133505
19Chronic myeloid leukemia_Homo sapiens_hsa052202.03441976
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00681806
21Fatty acid metabolism_Homo sapiens_hsa012121.99545448
22Peroxisome_Homo sapiens_hsa041461.94497285
23PPAR signaling pathway_Homo sapiens_hsa033201.85602745
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85319489
25Acute myeloid leukemia_Homo sapiens_hsa052211.79816303
26Pyruvate metabolism_Homo sapiens_hsa006201.79574388
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72078102
28Cell cycle_Homo sapiens_hsa041101.70954733
29beta-Alanine metabolism_Homo sapiens_hsa004101.68025478
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65886403
31Endometrial cancer_Homo sapiens_hsa052131.64472263
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61748957
33Selenocompound metabolism_Homo sapiens_hsa004501.60911476
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55248250
35Caffeine metabolism_Homo sapiens_hsa002321.54848033
36Thyroid cancer_Homo sapiens_hsa052161.54759693
37Carbon metabolism_Homo sapiens_hsa012001.54352893
38Chemical carcinogenesis_Homo sapiens_hsa052041.53993362
39ABC transporters_Homo sapiens_hsa020101.53289090
40Sulfur metabolism_Homo sapiens_hsa009201.51145123
41Histidine metabolism_Homo sapiens_hsa003401.50471033
42B cell receptor signaling pathway_Homo sapiens_hsa046621.49798152
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47458599
44Fatty acid elongation_Homo sapiens_hsa000621.47042830
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44796666
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43097317
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42960279
48mTOR signaling pathway_Homo sapiens_hsa041501.41548748
49Sulfur relay system_Homo sapiens_hsa041221.38238363
50Inositol phosphate metabolism_Homo sapiens_hsa005621.37066573
51FoxO signaling pathway_Homo sapiens_hsa040681.36552330
52Bile secretion_Homo sapiens_hsa049761.35975411
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.35099197
54Systemic lupus erythematosus_Homo sapiens_hsa053221.34723119
55Hepatitis B_Homo sapiens_hsa051611.32679399
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31436649
57Phenylalanine metabolism_Homo sapiens_hsa003601.30134224
58Non-homologous end-joining_Homo sapiens_hsa034501.28722439
59Biosynthesis of amino acids_Homo sapiens_hsa012301.28569952
60Starch and sucrose metabolism_Homo sapiens_hsa005001.28202889
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27930815
62Folate biosynthesis_Homo sapiens_hsa007901.27301499
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.27173834
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.26314344
65DNA replication_Homo sapiens_hsa030301.22934741
66Prostate cancer_Homo sapiens_hsa052151.22016259
67Renal cell carcinoma_Homo sapiens_hsa052111.21665564
68Viral carcinogenesis_Homo sapiens_hsa052031.21309997
69Platelet activation_Homo sapiens_hsa046111.16798959
70HIF-1 signaling pathway_Homo sapiens_hsa040661.16402509
71Retinol metabolism_Homo sapiens_hsa008301.15826039
72Staphylococcus aureus infection_Homo sapiens_hsa051501.15522661
73Measles_Homo sapiens_hsa051621.14174158
74Jak-STAT signaling pathway_Homo sapiens_hsa046301.14111633
75Tyrosine metabolism_Homo sapiens_hsa003501.13519613
76Apoptosis_Homo sapiens_hsa042101.13030855
77Fat digestion and absorption_Homo sapiens_hsa049751.12494000
78African trypanosomiasis_Homo sapiens_hsa051431.10008987
79Glioma_Homo sapiens_hsa052141.09929487
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02667411
81Prolactin signaling pathway_Homo sapiens_hsa049171.00773972
82Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00539873
83Hepatitis C_Homo sapiens_hsa051600.99013729
84Arginine and proline metabolism_Homo sapiens_hsa003300.98490189
85Glutathione metabolism_Homo sapiens_hsa004800.95734016
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93430387
87Nucleotide excision repair_Homo sapiens_hsa034200.92583295
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.89689261
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89664472
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88185056
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.87258517
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87242578
93Steroid biosynthesis_Homo sapiens_hsa001000.87052133
94p53 signaling pathway_Homo sapiens_hsa041150.86266002
95Osteoclast differentiation_Homo sapiens_hsa043800.83371658
96Base excision repair_Homo sapiens_hsa034100.81787035
97Mismatch repair_Homo sapiens_hsa034300.81080619
98Small cell lung cancer_Homo sapiens_hsa052220.80935366
99T cell receptor signaling pathway_Homo sapiens_hsa046600.79353578
100Legionellosis_Homo sapiens_hsa051340.78797067
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77391975
102Lysine degradation_Homo sapiens_hsa003100.75833043
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75755013
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73896400
105Hematopoietic cell lineage_Homo sapiens_hsa046400.73563017
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72712659
107Influenza A_Homo sapiens_hsa051640.70956452
108MicroRNAs in cancer_Homo sapiens_hsa052060.70176926
109VEGF signaling pathway_Homo sapiens_hsa043700.69482689
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68680076
111Vitamin digestion and absorption_Homo sapiens_hsa049770.68524972
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68416117
113Pentose phosphate pathway_Homo sapiens_hsa000300.68142942
114One carbon pool by folate_Homo sapiens_hsa006700.65836459
115Herpes simplex infection_Homo sapiens_hsa051680.65395310
116Glycerolipid metabolism_Homo sapiens_hsa005610.64753866
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63371451
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62791422
119Oocyte meiosis_Homo sapiens_hsa041140.60321266
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60212556
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.59857173
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58730027
123* Metabolic pathways_Homo sapiens_hsa011000.56617119
124Choline metabolism in cancer_Homo sapiens_hsa052310.55872928
125Leishmaniasis_Homo sapiens_hsa051400.54120090
126Melanoma_Homo sapiens_hsa052180.53578748
127mRNA surveillance pathway_Homo sapiens_hsa030150.53518965
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52788033
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.52651733
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51784132
131Epstein-Barr virus infection_Homo sapiens_hsa051690.51521899
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50878397
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.50787418
134Fatty acid biosynthesis_Homo sapiens_hsa000610.45228897
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41966248
136Insulin resistance_Homo sapiens_hsa049310.38224419
137Parkinsons disease_Homo sapiens_hsa050120.37494334
138AMPK signaling pathway_Homo sapiens_hsa041520.37316485
139Fructose and mannose metabolism_Homo sapiens_hsa000510.37029687
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33979147
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32753366
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31511665
143Oxidative phosphorylation_Homo sapiens_hsa001900.26596227
144Linoleic acid metabolism_Homo sapiens_hsa005910.25790157
145Galactose metabolism_Homo sapiens_hsa000520.24862689
146Alcoholism_Homo sapiens_hsa050340.24419562
147Glucagon signaling pathway_Homo sapiens_hsa049220.18140802
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.17442941
149Prion diseases_Homo sapiens_hsa050200.11139787
150Insulin signaling pathway_Homo sapiens_hsa049100.10785229
151Bladder cancer_Homo sapiens_hsa052190.10349882
152Alzheimers disease_Homo sapiens_hsa050100.09759552
153Regulation of autophagy_Homo sapiens_hsa041400.05392835
154Malaria_Homo sapiens_hsa051440.04665039
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04624841
156Cardiac muscle contraction_Homo sapiens_hsa042600.01870630
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01188320
158Collecting duct acid secretion_Homo sapiens_hsa04966-0.1272005
159Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0923754
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0836994
161Huntingtons disease_Homo sapiens_hsa05016-0.0585126
162Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0456322
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0189592
164Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0118020

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