FEM1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)9.15007011
2sarcomere organization (GO:0045214)7.66475515
3muscle filament sliding (GO:0030049)7.60680006
4actin-myosin filament sliding (GO:0033275)7.60680006
5regulation of skeletal muscle contraction (GO:0014819)6.67218631
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.56936141
7cardiac myofibril assembly (GO:0055003)6.51472606
8myofibril assembly (GO:0030239)6.49872237
9response to lipoprotein particle (GO:0055094)6.39718932
10plasma membrane repair (GO:0001778)6.30926543
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.26917411
12actin-mediated cell contraction (GO:0070252)6.15804119
13sarcoplasmic reticulum calcium ion transport (GO:0070296)6.10904442
14positive regulation of fatty acid oxidation (GO:0046321)6.00654323
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.86994139
16negative regulation of telomerase activity (GO:0051974)5.85514193
17carnitine shuttle (GO:0006853)5.80090065
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.74163651
19response to caffeine (GO:0031000)5.56471939
20cardiac muscle contraction (GO:0060048)5.54838741
21tricarboxylic acid cycle (GO:0006099)5.53841575
22striated muscle contraction (GO:0006941)5.19491889
23spindle assembly involved in mitosis (GO:0090307)5.14095579
24mitochondrial fusion (GO:0008053)5.13151219
25skeletal muscle contraction (GO:0003009)5.11976148
26fatty acid transmembrane transport (GO:1902001)5.11788954
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.00274263
28mitochondrion morphogenesis (GO:0070584)4.98566257
29actomyosin structure organization (GO:0031032)4.98249977
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.97241912
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.87286005
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.86887627
33creatine metabolic process (GO:0006600)4.84880141
34actin filament-based movement (GO:0030048)4.83100582
35cardiac muscle cell development (GO:0055013)4.71188532
36positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.70877977
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.68828041
38regulation of relaxation of muscle (GO:1901077)4.68519912
39regulation of actin filament-based movement (GO:1903115)4.65632649
40mitochondrial respiratory chain complex I assembly (GO:0032981)4.62338060
41NADH dehydrogenase complex assembly (GO:0010257)4.62338060
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62338060
43peripheral nervous system axon ensheathment (GO:0032292)4.61447741
44myelination in peripheral nervous system (GO:0022011)4.61447741
45white fat cell differentiation (GO:0050872)4.60368157
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.54434795
47positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.54409216
48regulation of cell communication by electrical coupling (GO:0010649)4.53881320
49skeletal muscle fiber development (GO:0048741)4.51339371
50regulation of energy homeostasis (GO:2000505)4.48630677
512-oxoglutarate metabolic process (GO:0006103)4.47856032
52prostate gland growth (GO:0060736)4.44451127
53regulation of tight junction assembly (GO:2000810)4.43576663
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.42192140
55regulation of acyl-CoA biosynthetic process (GO:0050812)4.41091566
56cardiac cell development (GO:0055006)4.40367912
57cardiac muscle hypertrophy (GO:0003300)4.39871353
58microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.34185616
59carnitine transmembrane transport (GO:1902603)4.30325850
60striated muscle hypertrophy (GO:0014897)4.26155445
61inner cell mass cell proliferation (GO:0001833)4.24262716
62positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.23588317
63ventricular cardiac muscle cell action potential (GO:0086005)4.21257419
64positive regulation of oligodendrocyte differentiation (GO:0048714)4.18252950
65skeletal muscle adaptation (GO:0043501)4.17579661
66anterior/posterior axis specification, embryo (GO:0008595)4.10052459
67negative regulation of Rho protein signal transduction (GO:0035024)4.08083279
68cellular response to lithium ion (GO:0071285)4.07812160
69response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.05671889
70regulation of telomerase activity (GO:0051972)4.05239891
71positive regulation of mitochondrial fission (GO:0090141)4.04877346
72somite development (GO:0061053)4.03689270
73regulation of cofactor metabolic process (GO:0051193)4.01801654
74regulation of coenzyme metabolic process (GO:0051196)4.01801654
75myotube cell development (GO:0014904)4.00925812
76DNA deamination (GO:0045006)4.00430380
77regulation of cell proliferation involved in kidney development (GO:1901722)4.00138450
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.99761209
79amino-acid betaine transport (GO:0015838)3.99036267
80carnitine transport (GO:0015879)3.99036267
81serine family amino acid catabolic process (GO:0009071)3.98725453
82regulation of striated muscle contraction (GO:0006942)3.96825162
83adult heart development (GO:0007512)3.94724108
84NADH metabolic process (GO:0006734)3.91059224
85regulation of sarcomere organization (GO:0060297)3.89927366
86centrosome duplication (GO:0051298)3.89733743
87regulation of cholesterol storage (GO:0010885)3.84392411
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.84119025
89cardiac muscle tissue morphogenesis (GO:0055008)3.82952986
90heart trabecula formation (GO:0060347)3.82188692
91regulation of membrane repolarization (GO:0060306)3.81297574
92glycogen catabolic process (GO:0005980)3.81166895
93muscle hypertrophy (GO:0014896)3.74573626
94positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.73587930
95muscle contraction (GO:0006936)3.71349304
96regulation of sequestering of triglyceride (GO:0010889)3.69696349
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69343008
98cell differentiation involved in embryonic placenta development (GO:0060706)3.68386833
99negative regulation of DNA biosynthetic process (GO:2000279)3.67140086
100ventricular septum development (GO:0003281)3.65799596
101striated muscle adaptation (GO:0014888)3.63976428
102response to inactivity (GO:0014854)3.63393145
103lung-associated mesenchyme development (GO:0060484)3.61279671
104bundle of His cell to Purkinje myocyte communication (GO:0086069)3.59642606
105cell communication involved in cardiac conduction (GO:0086065)3.59359421
106glucan catabolic process (GO:0009251)3.57811405
107lysine catabolic process (GO:0006554)3.57578962
108lysine metabolic process (GO:0006553)3.57578962
109tricarboxylic acid metabolic process (GO:0072350)3.56368642
110negative regulation of cell size (GO:0045792)3.56338801
111muscle tissue morphogenesis (GO:0060415)3.54778735
112protein complex biogenesis (GO:0070271)3.51858398
113regulation of fatty acid oxidation (GO:0046320)3.51547745
114oxaloacetate metabolic process (GO:0006107)3.51068699
115cardiac muscle adaptation (GO:0014887)3.50587795
116cardiac muscle hypertrophy in response to stress (GO:0014898)3.50587795
117muscle hypertrophy in response to stress (GO:0003299)3.50587795
118aspartate family amino acid catabolic process (GO:0009068)3.48978595
119heart contraction (GO:0060047)3.42620024
120heart process (GO:0003015)3.42620024
121muscle system process (GO:0003012)3.42291663
122regulation of calcium ion transmembrane transporter activity (GO:1901019)3.40986919
123regulation of calcium ion transmembrane transport (GO:1903169)3.40986919
124pyrimidine ribonucleoside catabolic process (GO:0046133)3.37982575
125regulation of the force of heart contraction (GO:0002026)3.34376210
126negative regulation of acute inflammatory response (GO:0002674)3.33567780
127cellular polysaccharide catabolic process (GO:0044247)3.31882580
128negative regulation of potassium ion transport (GO:0043267)3.31716909
129fatty acid beta-oxidation (GO:0006635)3.29920635
130regulation of sulfur metabolic process (GO:0042762)3.29322488
131succinate metabolic process (GO:0006105)3.29291275
132ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.29097691
133positive regulation of cation channel activity (GO:2001259)3.28642709
134mitochondrial respiratory chain complex assembly (GO:0033108)3.23195521
135glycogen biosynthetic process (GO:0005978)3.22983477
136glucan biosynthetic process (GO:0009250)3.22983477
137striated muscle cell development (GO:0055002)3.22298358
138skeletal muscle tissue development (GO:0007519)3.22129267
139regulation of mitochondrial fission (GO:0090140)3.19709588
140behavioral response to nicotine (GO:0035095)3.15006143
141cell communication by electrical coupling (GO:0010644)3.12739658
142striated muscle atrophy (GO:0014891)3.09369756
143muscle fiber development (GO:0048747)3.08967734
144polysaccharide catabolic process (GO:0000272)3.08817532
145response to muscle activity (GO:0014850)3.07772034
146glycogen metabolic process (GO:0005977)3.06641340
147calcium-mediated signaling using intracellular calcium source (GO:0035584)3.05536299
148regulation of ATP catabolic process (GO:1903289)3.01729901
149regulation of ATPase activity (GO:0043462)3.01729901
150interkinetic nuclear migration (GO:0022027)3.01566651
151negative regulation of kidney development (GO:0090185)3.01067413
152cellular glucan metabolic process (GO:0006073)3.00882094
153glucan metabolic process (GO:0044042)3.00882094
154positive regulation of glomerulus development (GO:0090193)2.98612371
155regulation of receptor binding (GO:1900120)2.96831932
156glycine metabolic process (GO:0006544)2.96302295
157muscle atrophy (GO:0014889)2.95556950
158mitochondrial calcium ion homeostasis (GO:0051560)2.94387004
159gland morphogenesis (GO:0022612)2.93375214
160regulation of transcription involved in cell fate commitment (GO:0060850)2.92663991
161regulation of inositol phosphate biosynthetic process (GO:0010919)2.92444862
162negative regulation of TOR signaling (GO:0032007)2.88664836
163response to activity (GO:0014823)2.85528459
164peristalsis (GO:0030432)2.85203794
165peroxisome fission (GO:0016559)2.82888759
166neuromuscular synaptic transmission (GO:0007274)2.82211549
167spinal cord development (GO:0021510)2.81470962
168cell proliferation in forebrain (GO:0021846)2.80113410
169negative regulation of lipid storage (GO:0010888)2.78397730
170cardiac septum development (GO:0003279)2.77373929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.60349633
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52032932
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47808598
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.40487004
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.06065178
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.02742610
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.02742610
8ZNF263_19887448_ChIP-Seq_K562_Human2.95067028
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.82445156
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60405376
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.59134403
12GBX2_23144817_ChIP-Seq_PC3_Human2.58697793
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.57093521
14TDRD3_21172665_ChIP-Seq_MCF-7_Human2.39187731
15* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38561693
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30119599
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.27519256
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27438813
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23277088
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19899249
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.19657736
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17880625
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13163015
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.12255128
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10822950
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09145205
27KDM2B_26808549_Chip-Seq_DND41_Human2.06994794
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.02388449
29LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99949389
30CLOCK_20551151_ChIP-Seq_293T_Human1.98048120
31ZNF274_21170338_ChIP-Seq_K562_Hela1.95649266
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93900382
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93900382
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93742285
35LXR_22292898_ChIP-Seq_THP-1_Human1.92525588
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.90235310
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.86693562
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85563404
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80744111
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.74020342
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72724760
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71556547
43TCF7_22412390_ChIP-Seq_EML_Mouse1.71023920
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70463714
45GATA1_22025678_ChIP-Seq_K562_Human1.66263495
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.66249819
47MYC_22102868_ChIP-Seq_BL_Human1.64447193
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.64343514
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63500178
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.63461821
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61324534
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57378178
53STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.56547236
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56146174
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53204766
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.50770369
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.48229248
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46844107
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.46572462
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.46410888
61AHR_22903824_ChIP-Seq_MCF-7_Human1.46082732
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44648780
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43885904
64GATA1_19941826_ChIP-Seq_K562_Human1.43751042
65RACK7_27058665_Chip-Seq_MCF-7_Human1.42256952
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41272954
67DROSHA_22980978_ChIP-Seq_HELA_Human1.40053353
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39623450
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37738869
70VDR_21846776_ChIP-Seq_THP-1_Human1.37608423
71GATA4_21415370_ChIP-Seq_HL-1_Mouse1.37173256
72KDM2B_26808549_Chip-Seq_K562_Human1.36759869
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35621896
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35368805
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35216171
76FUS_26573619_Chip-Seq_HEK293_Human1.34637529
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33755576
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.33719748
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33653668
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33127319
81* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31692170
82CTCF_27219007_Chip-Seq_Bcells_Human1.30779087
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29721802
84ER_23166858_ChIP-Seq_MCF-7_Human1.28808800
85CREB1_26743006_Chip-Seq_LNCaP_Human1.28339204
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27776322
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.26927255
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.26222297
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24217775
90* P68_20966046_ChIP-Seq_HELA_Human1.23404600
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21790285
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21665122
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20840324
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20690593
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.20260981
96* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20253628
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20197396
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19939700
99MYC_18940864_ChIP-ChIP_HL60_Human1.19910775
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19544539
101SPI1_23127762_ChIP-Seq_K562_Human1.19063878
102ATF3_27146783_Chip-Seq_COLON_Human1.17948563
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15403124
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15282762
105EZH2_22144423_ChIP-Seq_EOC_Human1.14127883
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13607540
107TP63_22573176_ChIP-Seq_HFKS_Human1.12726500
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11255215
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11146894
110MAF_26560356_Chip-Seq_TH1_Human1.10828631
111* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10070954
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09704241
113GATA2_19941826_ChIP-Seq_K562_Human1.09132672
114ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09055275
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08291904
116* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08120443
117RNF2_27304074_Chip-Seq_NSC_Mouse1.07934447
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07345426
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06948743
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05394185
121* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05367933
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04923812
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03835417
124CTCF_21964334_Chip-Seq_Bcells_Human1.03783857
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03425755
126SMC4_20622854_ChIP-Seq_HELA_Human1.02176775
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01608552
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01571908
129TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01466347
130* RAC3_21632823_ChIP-Seq_H3396_Human1.01019661
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99788986
132BCOR_27268052_Chip-Seq_Bcells_Human0.98367744
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.97355516
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97115525
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96425760
136NANOG_20526341_ChIP-Seq_ESCs_Human0.95775203
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.95757413
138UTX_26944678_Chip-Seq_JUKART_Human0.95496170
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95346321
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.94926906
141IGF1R_20145208_ChIP-Seq_DFB_Human0.94815263
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94374503
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94284505
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94234866
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93875565
146BCL6_27268052_Chip-Seq_Bcells_Human0.93516600
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93507880
148* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92959558
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.92942551
150* YY1_22570637_ChIP-Seq_MALME-3M_Human0.92448243
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92145751
152REST_21632747_ChIP-Seq_MESCs_Mouse0.91547507
153RING1B_27294783_Chip-Seq_ESCs_Mouse0.90849453
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90061266
155IRF1_19129219_ChIP-ChIP_H3396_Human0.88740197
156TAF2_19829295_ChIP-Seq_ESCs_Human0.87342505
157VDR_22108803_ChIP-Seq_LS180_Human0.86794495
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.86398323
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84567469
160AR_19668381_ChIP-Seq_PC3_Human0.83858185
161RXR_22108803_ChIP-Seq_LS180_Human0.83781843
162NCOR_22424771_ChIP-Seq_293T_Human0.83458359
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82913320
164P53_21459846_ChIP-Seq_SAOS-2_Human0.80888746
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80610814
166SRF_21415370_ChIP-Seq_HL-1_Mouse0.79863499
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.77694333
168AR_21572438_ChIP-Seq_LNCaP_Human0.77674157
169E2F1_20622854_ChIP-Seq_HELA_Human0.77106611
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76584840
171MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75393152
172SOX2_21211035_ChIP-Seq_LN229_Human0.74692617
173WDR5_24793694_ChIP-Seq_LNCAP_Human0.73869287
174AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73564920
175SA1_27219007_Chip-Seq_ERYTHROID_Human0.73277515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.16767487
2MP0003646_muscle_fatigue5.74111396
3MP0000751_myopathy5.29496096
4MP0000749_muscle_degeneration4.39033641
5MP0004084_abnormal_cardiac_muscle4.22869926
6MP0004036_abnormal_muscle_relaxation4.02887548
7MP0004145_abnormal_muscle_electrophysio3.70683166
8MP0004215_abnormal_myocardial_fiber3.54431650
9MP0004130_abnormal_muscle_cell3.29191060
10MP0005330_cardiomyopathy3.26202776
11MP0004087_abnormal_muscle_fiber3.24253130
12MP0002653_abnormal_ependyma_morphology3.20878594
13MP0001661_extended_life_span3.07989678
14MP0002106_abnormal_muscle_physiology2.92818282
15MP0000747_muscle_weakness2.91914375
16MP0000750_abnormal_muscle_regeneration2.78518920
17MP0002269_muscular_atrophy2.73175066
18MP0005620_abnormal_muscle_contractility2.70870632
19MP0003315_abnormal_perineum_morphology2.67425875
20MP0000516_abnormal_urinary_system2.65218696
21MP0005367_renal/urinary_system_phenotyp2.65218696
22MP0001485_abnormal_pinna_reflex2.64824362
23MP0000759_abnormal_skeletal_muscle2.56337696
24MP0002972_abnormal_cardiac_muscle2.44082325
25MP0005369_muscle_phenotype2.36430274
26MP0001849_ear_inflammation2.21583129
27MP0010630_abnormal_cardiac_muscle2.21453484
28MP0003137_abnormal_impulse_conducting2.07062514
29MP0000049_abnormal_middle_ear2.06673212
30MP0008775_abnormal_heart_ventricle2.05904636
31MP0004233_abnormal_muscle_weight2.03959414
32MP0003724_increased_susceptibility_to2.02140606
33MP0005385_cardiovascular_system_phenoty2.00201557
34MP0001544_abnormal_cardiovascular_syste2.00201557
35MP0004484_altered_response_of1.97746730
36MP0009053_abnormal_anal_canal1.94803187
37MP0003221_abnormal_cardiomyocyte_apopto1.79540334
38MP0005646_abnormal_pituitary_gland1.79216846
39MP0005666_abnormal_adipose_tissue1.79074040
40MP0003693_abnormal_embryo_hatching1.79005876
41MP0006036_abnormal_mitochondrial_physio1.75006001
42MP0004185_abnormal_adipocyte_glucose1.69653577
43MP0006138_congestive_heart_failure1.62540713
44MP0004510_myositis1.58853329
45MP0004085_abnormal_heartbeat1.57744692
46MP0003119_abnormal_digestive_system1.56161321
47MP0003705_abnormal_hypodermis_morpholog1.52626242
48MP0002332_abnormal_exercise_endurance1.42871493
49MP0002160_abnormal_reproductive_system1.38838618
50MP0000537_abnormal_urethra_morphology1.38467731
51MP0005076_abnormal_cell_differentiation1.37582559
52MP0005375_adipose_tissue_phenotype1.37072495
53MP0003828_pulmonary_edema1.35102247
54MP0008961_abnormal_basal_metabolism1.30047206
55MP0005670_abnormal_white_adipose1.28332247
56MP0002876_abnormal_thyroid_physiology1.25209540
57MP0000733_abnormal_muscle_development1.23001760
58MP0003283_abnormal_digestive_organ1.16403124
59MP0009765_abnormal_xenobiotic_induced1.09612715
60MP0002909_abnormal_adrenal_gland1.09336514
61MP0002234_abnormal_pharynx_morphology1.08896401
62MP0002108_abnormal_muscle_morphology1.08540580
63MP0009780_abnormal_chondrocyte_physiolo1.07674269
64MP0003937_abnormal_limbs/digits/tail_de1.05862150
65MP0002127_abnormal_cardiovascular_syste1.05508501
66MP0002138_abnormal_hepatobiliary_system1.05046499
67MP0002971_abnormal_brown_adipose1.03847727
68MP0000013_abnormal_adipose_tissue1.02849700
69MP0008872_abnormal_physiological_respon1.00357687
70MP0000003_abnormal_adipose_tissue1.00041687
71MP0000266_abnormal_heart_morphology0.96573438
72MP0003950_abnormal_plasma_membrane0.95489804
73MP0002078_abnormal_glucose_homeostasis0.94242647
74MP0005083_abnormal_biliary_tract0.94100318
75MP0004043_abnormal_pH_regulation0.87322786
76MP0009250_abnormal_appendicular_skeleto0.85784592
77MP0006035_abnormal_mitochondrial_morpho0.84545146
78MP0005266_abnormal_metabolism0.83202334
79MP0002282_abnormal_trachea_morphology0.82931460
80MP0002249_abnormal_larynx_morphology0.82407371
81MP0010368_abnormal_lymphatic_system0.81931139
82MP0000343_altered_response_to0.81651605
83MP0006292_abnormal_olfactory_placode0.77561674
84MP0009840_abnormal_foam_cell0.77051845
85MP0003806_abnormal_nucleotide_metabolis0.76690197
86MP0000534_abnormal_ureter_morphology0.76103230
87MP0000631_abnormal_neuroendocrine_gland0.75339368
88MP0005319_abnormal_enzyme/_coenzyme0.74261060
89MP0003567_abnormal_fetal_cardiomyocyte0.73555239
90MP0003938_abnormal_ear_development0.73357638
91MP0003879_abnormal_hair_cell0.73295309
92MP0005165_increased_susceptibility_to0.72567860
93MP0005365_abnormal_bile_salt0.72047130
94MP0004142_abnormal_muscle_tone0.71821329
95MP0005085_abnormal_gallbladder_physiolo0.70103648
96MP0000230_abnormal_systemic_arterial0.70087509
97MP0002118_abnormal_lipid_homeostasis0.67556000
98MP0003656_abnormal_erythrocyte_physiolo0.66819387
99MP0002128_abnormal_blood_circulation0.65708076
100MP0005334_abnormal_fat_pad0.64427641
101MP0002877_abnormal_melanocyte_morpholog0.64307806
102MP0004381_abnormal_hair_follicle0.64027206
103MP0003279_aneurysm0.63639205
104MP0002139_abnormal_hepatobiliary_system0.63582338
105MP0005187_abnormal_penis_morphology0.63500019
106MP0002751_abnormal_autonomic_nervous0.62391820
107MP0009384_cardiac_valve_regurgitation0.61667389
108MP0005535_abnormal_body_temperature0.61602642
109MP0003566_abnormal_cell_adhesion0.61273711
110MP0008770_decreased_survivor_rate0.61256855
111MP0003300_gastrointestinal_ulcer0.59812688
112MP0005174_abnormal_tail_pigmentation0.58985226
113MP0005584_abnormal_enzyme/coenzyme_acti0.58818557
114MP0000383_abnormal_hair_follicle0.57590660
115MP0005389_reproductive_system_phenotype0.57573932
116MP0003252_abnormal_bile_duct0.57472244
117MP0010329_abnormal_lipoprotein_level0.56848595
118MP0003191_abnormal_cellular_cholesterol0.56375731
119MP0002102_abnormal_ear_morphology0.56161195
120MP0005360_urolithiasis0.55348731
121MP0002822_catalepsy0.55028304
122MP0000678_abnormal_parathyroid_gland0.54703861
123MP0003936_abnormal_reproductive_system0.54036637
124MP0003195_calcinosis0.52826938
125MP0000467_abnormal_esophagus_morphology0.52110638
126MP0003045_fibrosis0.51767542
127MP0002277_abnormal_respiratory_mucosa0.50530733
128MP0000015_abnormal_ear_pigmentation0.50394366
129MP0003890_abnormal_embryonic-extraembry0.50267306
130MP0004858_abnormal_nervous_system0.50263908
131MP0003942_abnormal_urinary_system0.49328409
132MP0000609_abnormal_liver_physiology0.48595730
133MP0001963_abnormal_hearing_physiology0.46013614
134MP0000470_abnormal_stomach_morphology0.45752031
135MP0004270_analgesia0.45646166
136MP0001440_abnormal_grooming_behavior0.45261018
137MP0004147_increased_porphyrin_level0.45255708
138MP0001666_abnormal_nutrient_absorption0.44646323
139MP0009046_muscle_twitch0.42768750
140MP0002970_abnormal_white_adipose0.42089882
141MP0005452_abnormal_adipose_tissue0.41971309
142MP0005332_abnormal_amino_acid0.41544304
143MP0009115_abnormal_fat_cell0.40439609
144MP0005275_abnormal_skin_tensile0.39766321
145MP0001879_abnormal_lymphatic_vessel0.39270085
146MP0002693_abnormal_pancreas_physiology0.38965850
147MP0001765_abnormal_ion_homeostasis0.38191663
148MP0005448_abnormal_energy_balance0.36198554
149MP0002896_abnormal_bone_mineralization0.35948480
150MP0003948_abnormal_gas_homeostasis0.35698515
151MP0005451_abnormal_body_composition0.35307253

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.98216644
2Short 1st metacarpal (HP:0010034)6.98216644
3Exercise-induced myalgia (HP:0003738)6.97930892
4Exercise-induced muscle cramps (HP:0003710)6.56495575
5Calf muscle hypertrophy (HP:0008981)6.18864783
6Sudden death (HP:0001699)6.16257069
7Abnormality of the 1st metacarpal (HP:0010009)6.09599630
8Muscle hypertrophy of the lower extremities (HP:0008968)6.09105403
9Myoglobinuria (HP:0002913)5.38441256
10Muscle fiber splitting (HP:0003555)5.36864786
11Hyporeflexia of lower limbs (HP:0002600)5.20458490
12Muscle fiber inclusion bodies (HP:0100299)5.19299159
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.02424209
14Ventricular tachycardia (HP:0004756)4.85733510
15Difficulty running (HP:0009046)4.73732880
16Stenosis of the external auditory canal (HP:0000402)4.72359930
17Abnormality of the calf musculature (HP:0001430)4.70799349
18Type 1 muscle fiber predominance (HP:0003803)4.52526642
19Abnormality of the left ventricular outflow tract (HP:0011103)4.51137799
20Subaortic stenosis (HP:0001682)4.51137799
21Short phalanx of the thumb (HP:0009660)4.45492852
22EMG: myopathic abnormalities (HP:0003458)4.39438632
23Ectopic kidney (HP:0000086)4.36267392
24Nemaline bodies (HP:0003798)4.36118188
25Increased connective tissue (HP:0009025)4.35076841
26Oligomenorrhea (HP:0000876)4.18742584
27Asymmetric septal hypertrophy (HP:0001670)4.11219579
28Carpal bone hypoplasia (HP:0001498)4.09626544
29Rhabdomyolysis (HP:0003201)4.07496948
30Fused cervical vertebrae (HP:0002949)3.97662350
31Atrial fibrillation (HP:0005110)3.86054690
32Lipoatrophy (HP:0100578)3.77102672
33Distal arthrogryposis (HP:0005684)3.72484541
34Myotonia (HP:0002486)3.66838682
35Primary atrial arrhythmia (HP:0001692)3.62579839
36Right ventricular cardiomyopathy (HP:0011663)3.62290745
37Bundle branch block (HP:0011710)3.57960929
38Abnormality of the renal collecting system (HP:0004742)3.57693810
39Short hallux (HP:0010109)3.53038001
40Absent thumb (HP:0009777)3.48921658
41Supraventricular tachycardia (HP:0004755)3.48105046
42Myopathic facies (HP:0002058)3.46711791
43Duplicated collecting system (HP:0000081)3.41817199
44Supraventricular arrhythmia (HP:0005115)3.41595053
45Difficulty climbing stairs (HP:0003551)3.34246779
46Dilated cardiomyopathy (HP:0001644)3.31962013
47Muscle stiffness (HP:0003552)3.31892090
48Rectal fistula (HP:0100590)3.31354963
49Rectovaginal fistula (HP:0000143)3.31354963
50Aplasia/Hypoplasia involving the musculature (HP:0001460)3.29021501
51Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.28493893
52Decreased subcutaneous fat (HP:0001002)3.25197728
53Aplasia/Hypoplasia of the hallux (HP:0008362)3.22536772
54Round ear (HP:0100830)3.21471858
55Syncope (HP:0001279)3.15653990
56Abnormality of skeletal muscle fiber size (HP:0012084)3.12123589
57Increased variability in muscle fiber diameter (HP:0003557)3.11778077
58Toxemia of pregnancy (HP:0100603)3.11278174
59Reduced subcutaneous adipose tissue (HP:0003758)3.10963167
60Prolonged QT interval (HP:0001657)3.09697038
61Palpitations (HP:0001962)3.09110966
62Paralysis (HP:0003470)3.07742697
63Intestinal fistula (HP:0100819)3.02767839
64Ketoacidosis (HP:0001993)2.99749063
65Abnormal finger flexion creases (HP:0006143)2.97634750
66Ulnar deviation of the wrist (HP:0003049)2.95076042
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.93506552
68Ventricular arrhythmia (HP:0004308)2.93397202
69Heart block (HP:0012722)2.91338212
70Osteomalacia (HP:0002749)2.84848571
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84577314
72Atrioventricular block (HP:0001678)2.82372883
73Vaginal fistula (HP:0004320)2.76309244
74Abnormal atrioventricular conduction (HP:0005150)2.74571905
75Neck muscle weakness (HP:0000467)2.71951220
76Hypoglycemic coma (HP:0001325)2.67945966
77Areflexia of lower limbs (HP:0002522)2.64028265
78Abnormality of DNA repair (HP:0003254)2.63184126
79Maternal diabetes (HP:0009800)2.60634125
80Rimmed vacuoles (HP:0003805)2.54888951
81Ventricular fibrillation (HP:0001663)2.54708192
82Increased purine levels (HP:0004368)2.53630866
83Hyperuricemia (HP:0002149)2.53630866
84Frequent falls (HP:0002359)2.52120421
85Limb-girdle muscle atrophy (HP:0003797)2.52063436
86Abnormality of the parathyroid morphology (HP:0011766)2.51037252
87Abnormality of subcutaneous fat tissue (HP:0001001)2.50829092
88Synostosis of carpal bones (HP:0005048)2.50443830
89Severe muscular hypotonia (HP:0006829)2.45215578
90Ketosis (HP:0001946)2.44904463
91EMG: neuropathic changes (HP:0003445)2.43915216
92Acanthocytosis (HP:0001927)2.42896586
93Chromsome breakage (HP:0040012)2.39339846
94Short humerus (HP:0005792)2.39247156
95Short thumb (HP:0009778)2.37741185
96Mildly elevated creatine phosphokinase (HP:0008180)2.36698113
97Absent radius (HP:0003974)2.30763460
98Abnormality of the nasal septum (HP:0000419)2.28262077
99Horseshoe kidney (HP:0000085)2.21615244
100Distal lower limb muscle weakness (HP:0009053)2.21329206
101Abnormality of the shoulder girdle musculature (HP:0001435)2.19871619
102Distal lower limb amyotrophy (HP:0008944)2.19768038
103Absent forearm bone (HP:0003953)2.19618261
104Aplasia involving forearm bones (HP:0009822)2.19618261
105Conjunctival hamartoma (HP:0100780)2.18589688
106Abnormal EKG (HP:0003115)2.18385111
107Hypoplastic ischia (HP:0003175)2.17484306
108Hyperinsulinemic hypoglycemia (HP:0000825)2.17229536
109Aplasia/hypoplasia of the humerus (HP:0006507)2.16965603
110Facial diplegia (HP:0001349)2.15691091
111Scapular winging (HP:0003691)2.14709174
112Proximal amyotrophy (HP:0007126)2.10290150
113Hamartoma of the eye (HP:0010568)2.09859294
114Acute necrotizing encephalopathy (HP:0006965)2.09325338
115Progressive muscle weakness (HP:0003323)2.08652224
116Testicular atrophy (HP:0000029)2.05574195
117Muscular dystrophy (HP:0003560)2.05553698
118Centrally nucleated skeletal muscle fibers (HP:0003687)2.03794145
119Pendular nystagmus (HP:0012043)2.03623198
120Generalized muscle weakness (HP:0003324)2.03456223
121Congenital sensorineural hearing impairment (HP:0008527)2.03444406
122Dysmetric saccades (HP:0000641)2.02624642
123Vertebral fusion (HP:0002948)2.02414487
124External ophthalmoplegia (HP:0000544)2.02195372
125Abnormality of fatty-acid metabolism (HP:0004359)2.01227342
126Calcaneovalgus deformity (HP:0001848)2.00544002
127Symphalangism affecting the phalanges of the hand (HP:0009773)1.99425541
128Abnormal mitochondria in muscle tissue (HP:0008316)1.96625852
129Hyperglycemia (HP:0003074)1.95867308
130Left ventricular hypertrophy (HP:0001712)1.95333031
131Gowers sign (HP:0003391)1.94338568
132Reticulocytopenia (HP:0001896)1.93661414
133Hyperalaninemia (HP:0003348)1.93451682
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93451682
135Abnormality of alanine metabolism (HP:0010916)1.93451682
136Cholelithiasis (HP:0001081)1.91581401
137Abnormality of the carotid arteries (HP:0005344)1.91015299
138Anal stenosis (HP:0002025)1.90738398
139Abnormality of the ischium (HP:0003174)1.89531221
140Absent phalangeal crease (HP:0006109)1.88812095
141Large for gestational age (HP:0001520)1.88144445
142Morphological abnormality of the middle ear (HP:0008609)1.88082781
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.84731435
144Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84382806
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83202132
146Dicarboxylic aciduria (HP:0003215)1.83202132
147Lower limb amyotrophy (HP:0007210)1.82723592
148Limb-girdle muscle weakness (HP:0003325)1.82688336
149Chorioretinal atrophy (HP:0000533)1.80517624
150Abnormality of the foot musculature (HP:0001436)1.80380803
151Foot dorsiflexor weakness (HP:0009027)1.78731757
152Deformed tarsal bones (HP:0008119)1.78385059
153Palmoplantar keratoderma (HP:0000982)1.76607973
154Malignant hyperthermia (HP:0002047)1.76507639
155Abnormal gallbladder morphology (HP:0012437)1.75323763
156Broad metatarsal (HP:0001783)1.73475479
157Hepatic necrosis (HP:0002605)1.73073976
158Increased muscle lipid content (HP:0009058)1.72924891
159Insulin-resistant diabetes mellitus (HP:0000831)1.72750179
160Lymphangioma (HP:0100764)1.71464057
161Ragged-red muscle fibers (HP:0003200)1.70847464
162Hypoalphalipoproteinemia (HP:0003233)1.70624614
163Hyperkalemia (HP:0002153)1.70528199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.99479638
2OBSCN5.00367446
3PHKG14.17308696
4PHKG24.17308696
5TRIB34.14429452
6PKN23.71692643
7GRK13.07613726
8TLK12.79928568
9CDK92.71165905
10DMPK2.62953574
11FRK2.55645664
12PDK42.50694178
13PDK32.50694178
14BCKDK2.45364867
15LMTK22.27101977
16NEK12.02855164
17MAP3K71.80020516
18MAP2K31.75005317
19PINK11.60343566
20ADRBK21.59970829
21PIK3CA1.57992019
22RIPK11.52994011
23MYLK1.51358471
24NME11.47348469
25EEF2K1.39119386
26BMPR1B1.38714586
27ACVR1B1.30410804
28MUSK1.29336727
29PDK21.29175700
30PIK3CG1.27727273
31CDC71.25331942
32MAPK121.23042235
33ZAK1.21577011
34MAP3K101.15938777
35SIK11.12721357
36TIE11.06607637
37PRKD11.05278769
38ERN11.02040763
39INSRR1.01602160
40STK241.01520179
41PTK60.99441397
42PRKAA10.96923873
43ILK0.95778546
44FLT30.94297403
45MAP2K40.92899566
46MAPK130.92182249
47PDGFRA0.88949839
48PAK30.87718521
49PRKAA20.87628564
50TAOK10.80688109
51DAPK20.78880478
52KSR20.73856770
53RPS6KA60.73537874
54EPHB10.71806079
55RET0.69177962
56MAPKAPK30.69098425
57ICK0.66769376
58CAMK1G0.65668138
59SGK20.64188400
60RPS6KB10.62263422
61PRKD30.61837517
62MAP2K70.61729821
63ROCK10.61174929
64ATR0.61138351
65CAMK2D0.60701810
66LRRK20.60078532
67CDC42BPA0.59279337
68PRKCH0.59093265
69BLK0.58223422
70CAMK1D0.57261517
71PDPK10.57148756
72MAP3K30.56985721
73CCNB10.56785551
74MAP3K50.56347851
75PDK10.55024215
76CAMK40.54563469
77STK160.53661859
78AURKA0.53006312
79MARK10.52736608
80SYK0.52534154
81CSNK1D0.52085008
82FGFR40.52020645
83MAP3K10.51459568
84TGFBR20.51344802
85PAK60.51210002
86PRKD20.49797519
87TRPM70.49728933
88PLK20.49693502
89RPS6KA50.49582198
90LATS10.49296609
91MAP3K130.48625795
92PKN10.48406691
93CSNK1A10.47446258
94MTOR0.45913062
95JAK10.45811883
96SGK4940.44394063
97SGK2230.44394063
98MAPK110.43368279
99JAK20.42681157
100STK380.42249881
101NEK90.41875111
102MAP3K110.41174225
103DAPK30.41049328
104SGK30.40433704
105MAPK70.40401044
106MAP4K10.40010973
107MAPK80.39559521
108MARK20.39478370
109MAP2K60.39334522
110AKT20.38308721
111MKNK20.38110091
112WNK40.38096023
113CAMK2A0.36465658
114MAP2K20.36425727
115DYRK30.35481393
116CAMKK10.35339216
117PRKACB0.35319452
118CAMK10.35247473
119CAMK2G0.35088391
120MAPK40.34677528
121STK110.34334058
122STK40.33829509
123PRKACG0.33742076
124CSNK1A1L0.32157714
125MELK0.31837313
126TGFBR10.31719201
127STK38L0.31663394
128MAP3K40.31420723
129GSK3B0.30361164
130FGFR30.30110090
131BMX0.29779273
132CAMK2B0.29746674
133RPS6KA20.29538874
134ADRBK10.29022686
135PTK2B0.28387248
136SGK10.28135314
137MAPK30.28119121
138RPS6KC10.27730538
139RPS6KL10.27730538
140IKBKB0.27593211
141RPS6KA30.27173442
142MAPKAPK50.26960241
143MAPK150.26913064
144MAPK90.26681914
145ROCK20.26099904
146CDK50.25990427
147MAP2K10.25351564
148RPS6KA10.24656577
149CSNK1G30.24412397
150CSNK1G20.23993184
151PRKDC0.23882469
152TYK20.23350145
153PRKACA0.23229930
154PRKG10.23202150
155MAPK140.23106301
156HIPK20.22669144
157SCYL20.22621397

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.09093192
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.03017004
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.88709855
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53517926
5Sulfur metabolism_Homo sapiens_hsa009203.24346338
6Dilated cardiomyopathy_Homo sapiens_hsa054143.06155920
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.00987512
8Cardiac muscle contraction_Homo sapiens_hsa042602.95698491
9Propanoate metabolism_Homo sapiens_hsa006402.95055682
10Fatty acid degradation_Homo sapiens_hsa000712.76764785
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29766870
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27531191
13Carbon metabolism_Homo sapiens_hsa012002.26366229
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21590188
15Sulfur relay system_Homo sapiens_hsa041222.18506737
16Renin-angiotensin system_Homo sapiens_hsa046142.16912237
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12959214
18Selenocompound metabolism_Homo sapiens_hsa004502.08672142
19Fatty acid metabolism_Homo sapiens_hsa012122.06308365
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85319504
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71624454
22Insulin resistance_Homo sapiens_hsa049311.67128254
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66302405
24Pyruvate metabolism_Homo sapiens_hsa006201.58253413
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56664525
26Butanoate metabolism_Homo sapiens_hsa006501.53807199
27Phototransduction_Homo sapiens_hsa047441.51435371
28Starch and sucrose metabolism_Homo sapiens_hsa005001.51394811
29Fanconi anemia pathway_Homo sapiens_hsa034601.49894019
30Insulin signaling pathway_Homo sapiens_hsa049101.48964855
31Glucagon signaling pathway_Homo sapiens_hsa049221.48500908
32Thyroid cancer_Homo sapiens_hsa052161.46434097
33Parkinsons disease_Homo sapiens_hsa050121.36238592
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.35638264
35Viral myocarditis_Homo sapiens_hsa054161.35034854
36Arginine biosynthesis_Homo sapiens_hsa002201.33005076
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29350414
38Biosynthesis of amino acids_Homo sapiens_hsa012301.25961452
39Nicotine addiction_Homo sapiens_hsa050331.25400974
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21613327
41PPAR signaling pathway_Homo sapiens_hsa033201.19564106
42Basal cell carcinoma_Homo sapiens_hsa052171.18621703
43Type II diabetes mellitus_Homo sapiens_hsa049301.17742670
44AMPK signaling pathway_Homo sapiens_hsa041521.15916203
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14558983
46Alzheimers disease_Homo sapiens_hsa050101.12553814
47Lysine degradation_Homo sapiens_hsa003101.12512920
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08708990
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06173319
50Tryptophan metabolism_Homo sapiens_hsa003801.06164302
51Nitrogen metabolism_Homo sapiens_hsa009101.01383795
52Oxidative phosphorylation_Homo sapiens_hsa001901.01186493
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00412042
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99214901
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98546826
56Oxytocin signaling pathway_Homo sapiens_hsa049210.98405948
57RNA degradation_Homo sapiens_hsa030180.98116305
58Linoleic acid metabolism_Homo sapiens_hsa005910.96206806
59Collecting duct acid secretion_Homo sapiens_hsa049660.94731638
60Systemic lupus erythematosus_Homo sapiens_hsa053220.94156538
61Morphine addiction_Homo sapiens_hsa050320.89430249
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86793964
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.83352252
64Insulin secretion_Homo sapiens_hsa049110.82329994
65Galactose metabolism_Homo sapiens_hsa000520.79213984
66Calcium signaling pathway_Homo sapiens_hsa040200.77463443
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76433389
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76265071
69mTOR signaling pathway_Homo sapiens_hsa041500.75760543
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75744701
71Homologous recombination_Homo sapiens_hsa034400.75723924
72beta-Alanine metabolism_Homo sapiens_hsa004100.74692931
73Focal adhesion_Homo sapiens_hsa045100.71954774
74Gastric acid secretion_Homo sapiens_hsa049710.71761059
75RNA polymerase_Homo sapiens_hsa030200.71753447
76Fatty acid biosynthesis_Homo sapiens_hsa000610.69709713
77Axon guidance_Homo sapiens_hsa043600.69198554
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67501233
79Ether lipid metabolism_Homo sapiens_hsa005650.66782499
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.65578240
81Renin secretion_Homo sapiens_hsa049240.65440393
82HIF-1 signaling pathway_Homo sapiens_hsa040660.63483145
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62396088
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61851011
85Fat digestion and absorption_Homo sapiens_hsa049750.61752507
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61016556
87Arginine and proline metabolism_Homo sapiens_hsa003300.60816217
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60464841
89Histidine metabolism_Homo sapiens_hsa003400.60068086
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60013239
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59572656
92MAPK signaling pathway_Homo sapiens_hsa040100.59418047
93Fatty acid elongation_Homo sapiens_hsa000620.58395189
94Salivary secretion_Homo sapiens_hsa049700.57877762
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57560294
96Fructose and mannose metabolism_Homo sapiens_hsa000510.57011085
97VEGF signaling pathway_Homo sapiens_hsa043700.56927865
98Circadian rhythm_Homo sapiens_hsa047100.56409479
99Bile secretion_Homo sapiens_hsa049760.56213738
100Alcoholism_Homo sapiens_hsa050340.55935609
101One carbon pool by folate_Homo sapiens_hsa006700.55263105
102Pancreatic secretion_Homo sapiens_hsa049720.50805209
103Ovarian steroidogenesis_Homo sapiens_hsa049130.49971881
104Peroxisome_Homo sapiens_hsa041460.49051134
105GnRH signaling pathway_Homo sapiens_hsa049120.48689886
106Huntingtons disease_Homo sapiens_hsa050160.48392176
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47602572
108GABAergic synapse_Homo sapiens_hsa047270.47035614
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46276550
110Melanoma_Homo sapiens_hsa052180.46177213
111Platelet activation_Homo sapiens_hsa046110.44562336
112Phenylalanine metabolism_Homo sapiens_hsa003600.43080964
113Renal cell carcinoma_Homo sapiens_hsa052110.41329168
114Tight junction_Homo sapiens_hsa045300.41084823
115cAMP signaling pathway_Homo sapiens_hsa040240.40636107
116Taste transduction_Homo sapiens_hsa047420.40561943
117ABC transporters_Homo sapiens_hsa020100.38339382
118Hippo signaling pathway_Homo sapiens_hsa043900.38024567
119Glutamatergic synapse_Homo sapiens_hsa047240.37399029
120Circadian entrainment_Homo sapiens_hsa047130.36826215
121Melanogenesis_Homo sapiens_hsa049160.36685940
122Cholinergic synapse_Homo sapiens_hsa047250.35822600
123Glycerolipid metabolism_Homo sapiens_hsa005610.34275228
124Non-small cell lung cancer_Homo sapiens_hsa052230.34251354
125TGF-beta signaling pathway_Homo sapiens_hsa043500.33345597
126FoxO signaling pathway_Homo sapiens_hsa040680.32215368
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31823449
128Chronic myeloid leukemia_Homo sapiens_hsa052200.31369589
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30792283
130Glioma_Homo sapiens_hsa052140.30400229
131Long-term potentiation_Homo sapiens_hsa047200.30018096
132Estrogen signaling pathway_Homo sapiens_hsa049150.28582103
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.28049283
134Gap junction_Homo sapiens_hsa045400.28039221
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27732951
136Proteoglycans in cancer_Homo sapiens_hsa052050.27159096
137Acute myeloid leukemia_Homo sapiens_hsa052210.26876569
138Dorso-ventral axis formation_Homo sapiens_hsa043200.26864639
139Amoebiasis_Homo sapiens_hsa051460.26645617
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.26615065
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.25474129
142B cell receptor signaling pathway_Homo sapiens_hsa046620.23795899
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.22346885

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »